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MARIA MADAJKA, PH.

D
3219 Meadowbrook Boulevard, Apartment 301, Cleveland Heights, Ohio 44118
(740) 274-0628
mariamad@go2.pl

SUMMARY OF QUALIFICATIONS
Competent, innovative, and performance-driven professional, equipped with proven
expertise in numerous scientific approaches with focus on biochemistry, microbi
ology, molecular biology, and immunology; strongly inclined to pursue a career a
s Academic Teacher / Scientist to utilize extensive science research and teachin
g background and further develop communication, administration, and strategic pl
anning skills while achieving career progression. Demonstrate ability in develop
ing and implementing innovative programs and curriculums that contribute to acad
emic success. Possess in-depth knowledge of deploying diverse experimental metho
ds and cutting-edge technologies to deliver high-quality products. Utilize solid
communication and interpersonal skills in working collaboratively with cultural
ly diverse people.

KEY STRENGTHS
Research and Development In Vitro and In Vivo Studies
Quality Control and Assurance
Analysis and Problem Resolution Project Planning and Implementation
Laboratory Organization

TECHNICAL SUMMARY
MOLECULAR BIOLOGY
RNA and DNA Isolation and Purification ~ Cell Culture Monitoring ~ Western Blot
~ Multicolor FACS ~ Immunostaining ~ Confocal and Light Microscopy ~ In Vivo and
In Vitro analysis of Nitric Oxide
BIOCHEMISTRY
Quantitative and Visual Analysis of Bone Structure by microCT ~ Laser Doppler An
alysis of Blood Flow ~ In Vivo Imaging of Prostate Cancer by Xenogene
SMALL ANIMAL SURGERY
Intracerebral Hemorrhage Stroke ~ Wound Healing ~ Femoral Artery Ischemia ~ Pros
tate Cancer Animal Models ~ Bone Marrow Transplantation ~ Platelets Isolation
COMPUTER SKILLS
Microsoft Office Suite (Word, Excel, and PowerPoint) ~ Origin ~ Diva ~ Cell Ques
t

EDUCATION

2007
Ohio University, Athens, Ohio
DOCTOR OF PHILOSOPHY IN MOLECULAR AND CELLULAR BIOLOGY
Dissertation: "Nitroxidative Stress Induced Intracerebral Hemorrhage Stroke in t
he Brain-a Nanomedical Approach"
Cumulative GPA of 3.68

2001
Adam Mickiewicz University, Poznan, Poland
MASTER OF SCIENCE IN BIOTECHNOLOGY
Thesis: "Molecular Cloning and Sequencing of Methionylo t-RNA from Thermomyces
Lanuginosum"
Cumulative GPA of 4.0

TEACHING EXPERIENCE

2009 Cleveland Clinic, Cleveland, Ohio


RESEARCH ASSOCIATE
Conceptualized, developed, and implemented innovative courses for Vasculata work
shop to ensure high quality education. Administered various protocols and presen
ted practical guidelines to attendees. Mentored Angiogenesis, hind limb ischemia
model of arteriogenesis in mice, including surgery, Doppler flow measurements,
follow-up tissue processing and staining, and angiogenesis in wound and tumor. P
rovided efficient performance in teaching MicroCT analysis of vasculature; perfu
sion techniques, data acquisition and analysis.

2001-2006 Ohio University, Athens, Ohio


TEACHING ASSISTANT
Played an integral role in managing all aspects of laboratory operations, assume
d full responsibility in directing and training all laboratory members and techn
icians throughout the entire laboratory procedures. Maintained and performed inv
entory of research tools and instruments to ensure smooth and efficient processe
s. Skillfully directed and mentored undergraduate and master’s students. Provided pr
imary oversight to various teaching operations, such as preparing lectures, form
ulating experiment designs, checking and grading examinations and homework for b
iochemistry, general chemistry, introduction to organic chemistry, and general b
iology courses. Proactively involved and contributed new teaching concepts and i
deas in departmental meetings.

1998-2000 Adam Mickiewicz University, Poznan, Poland


TUTOR
Demonstrated knowledge and taught various subjects, cell biology, zoology, bioch
emistry, general chemistry, and human physiology. Acquired experience in teachin
g various students and groups.

RESEARCH EXPERIENCE

2009-PRESENT Cleveland Clinic, Department of Plastic Surgery, Cleveland, Ohio


RESEARCH ASSOCIATE
Conduct extensive analysis and examination on various research projects related
to immunological aspects of transplantation, cellular therapies, and stem cells
therapies in transplant acceptance, and peripheral nerve regeneration during ste
m cell therapy. Provide efficient performance in managing various duties, such a
s grant writing, drafting and editing numerous scientific papers, along with col
lecting and interpreting diverse data and information. Monitor all functional ar
eas of various projects within the laboratory, as well as in charge of managing
and developing new cellular therapies and conceptualizing new methods and techni
ques.

2007-2009 Cleveland Clinic, Cleveland, Ohio


POSTDOCTORAL RESEARCH FELLOW
Employed comprehensive evaluation and analytical skills in researching prostate
cancer metastasis mechanism. Directed and coordinated animal surgery. Spearhead
ed the evaluation and analysis of cell cultures, as well as held responsible for
the development of new biological assays. Performed ongoing in vitro and in viv
o data analysis. Created and prepared grants and various scientific papers. Faci
litated training to undergraduate students, as well as rendered consultation and
guidance in experimental procedures and techniques. Successfully designed and d
eveloped animal prostate cancer models, genetically modified prostate cancer cel
l lines to minimize invasiveness.

2004-2006 Ohio University, Athens, Ohio


RESEARCH ASSISTANT
Conducted extensive analysis and examination on various research projects relate
d to nitroxidative stress in stroke brain pathology. Engaged in various operatio
ns, including analyzing and interpreting diverse scientific information, draftin
g and collecting research data, conducting animal surgery and postoperative care
, and directing undergraduate students in various laboratory processes. Led the
design and development of new surgical techniques and conducted state-of-the-art
measurements of nitric oxide in the brain in vivo; provided detailed informatio
n and explained the role of nitric oxide in the mechanism of neuronal degenerati
on during stroke.

1999-2001 Polish Academy of Sciences, Poznan, Poland


RESEARCH ASSISTANT
Facilitated bacterial cells cultures and protein purification. Led efforts towar
d the successful genetically modification of bacterial cultures for the expressi
on of translational factors, which was further used for structural studies.

PROFESSIONAL TRAINING
2009 Vasculata, Cleveland Clinic, Cleveland, Ohio
Workshop organized by the North American Vascular Biology Organization

2008 Becton Dickinson, Billerica, Massachusetts


FACS Canto II Operator Course

2008 Vasculata, Seattle University


Vascular biology and tumor pathology training for entry level postdoctoral fello
ws

AWARDS AND HONORS


2007 Outstanding Teaching Assistant Award
Ohio University, Athens, Ohio

2000 Outstanding Student Scholarship


Bayreuth University, Germany

PUBLISHED BOOK
†Nitroxidative Stress in Intracerebral Hemorrhage Strokeâ€
Madajka M. VDM Publishing House, Germany, 2009

PUBLICATIONS
"Intraosseus Injection of RM1 Murine Prostate Cancer Cells Promotes Rapid Osteol
ysis and Periosteal Bone Depositionâ€
McCabe NP, Madajka M, Vasanji A, and Byzova TV; Metastasis, 2008; 25(5):581-90
"Restoration of Endothelial Function via Enhanced Nitric Oxide Synthesis After L
ong-Term Treatment of Raloxifene in Adult Hypertensive Ratsâ€
Leitzbach D, Weckler N, Madajka M, Malinski T, Wiemer G, and Linz W. Arzneimitte
lforschung, 2005; 55 (2): 86-92
“Combined Effects of Amiodipine and Atorvastatin and Endothelial Dysfunction In Vitr
oâ€
Mason P, Kalinowski L, Madajka M, Soneja A, Jacob R, Day C, and Malinski T.; Cir
culation, 2005; 112(17); abstract number 1053
“Effect of Aspirin on Constitutive Nitric Oxide Synthase and the Bioavailability of
NO"
Madajka M, Korda M, White J, and Malinski T.; Thromb Res, June 2003, 110(5-6):31
7-21
"Leptin Increases the Bioavailability in Human Vascular Endothelial Cells
" Korda M, Madajka M, and Malinski T; International Journal of Obesity, 2003; Ab
stract number 27
"Synergistic Stimulation of Nitric Oxide Cascade Release from Human Endothelial
Cells with Amiodipine and Atorvastatin"
Mason P, Jacob R, Kay RD, Kalinowski L, Madajka M, Dobrucki LW, Malinski T; Euro
pean Heart Journal, 2003; 24: 214-214, suppl.S, ISSN: 0195-668
"Endothelin-1stimulates NO Release in the Brain and Causes a Fall in Blood Press
ure"
Kalinowski L, Madajka M, White J, Bohr D, and Malinski T; In Heart Disease: Path
ogenesis, Diagnosis, and Treatment, Proceedings of the International Academy of
Cardiology, Washington, District of Columbia , 2003
†Participation of aminoacyl-tRNA synthetases in cellular processes"
Kaminska M, Zakrzewska A, Madajka M, and Barciszewski J.; Postepy Biochem, 2002,
48(3):189-99

CITATIONS
2010 Virgin Olive Oil Administration Improves the Effect of Aspirin on Retina
l Vascular Pattern in Experimental Diabetes Mellitus
British Journal of Nutrition; published online by Cambridge University Press 30
2009 eNOS Gene Influences Platelet Phenotype in Acute Coronary Syndrome patie
nts on Dual Antiplatelet treatment
Platelets, Vol.20, No.8, pp 548-554
2009 Platelet Aggregability is Modulated by eNOS Locus in Non–Type 2 Diabetic Pat
ients withAcute Coronary Syndrome
Nutrition, Metabolism and Cardiovascular Diseases, Available online 9
2008 Effects of Hydroxytyrosol and Hydroxytyrosol Acetate Administration to R
ats on Platelet Function Compared to Acetylsalicylic Acid
J.Agric.Food Chem., 56 (17), pp 7872-7876
2007 Raloxifene Similarly Affects the Skeletal System of Male and Ovariectomi
zed Female Rats
Pharmacological Reports, 59, 349-358
2005 The Effect of Exogenous Nitric Oxide on Zn Homeostasis
Master dissertation, B. Mohavdans, Ohio University, Athens, Ohio

CONFERENCES
2010 AFIRM, St. Pete’s Beach, Florida
2008 Midwest Platelet Conference, Lexington, Kentucky
2004 FASEB, Washington, District of Columbia

SEMINARS AND PUBLIC APPEARANCES


Restoration of Peripheral Nerve with Epineural Sheath and Bone Marrow Stromal Ce
lls Therapy
53rd Annual Meeting of The Ohio Valley Plastic Surgeons, Cleveland, Ohio
, 2010
The role of Nerve Growth Factor in Bone Marrow Stromal Cells Therapy during nerv
e regeneration
Presentation for Mucoskeletal Transplant Foundation, Cleveland, Ohio, 20
10
Antidonor Antibody in Composite Tissue Allografts During Different Cellular Ther
apies
Armed Forces Institute of Regenerative Medicine Conference, St.Pete’s Beach, Florida
, January, 2010
Research and Education in Modern Biotechnology, Oral Presentation for Undergradu
ate Students
Srem, Poland, November, 2009
Platelets and Hematopoietic Stem Cells in Vascular Remodeling
Cleveland Clinic, Cleveland, Ohio, 2009
The Recruitment of Bone Marrow Derived Cells by Platelets During Angiogenesis
Poster Presentation, John Carroll, University, Ohio, 2008
The Role of Integrins in the Metastasis of Prostate Cancer
Cleveland Clinic, Cleveland, Ohio, 2007
Role of Tumor Integrins in Bone Lesion Development; Skeletal Complications of Ma
lignancy V
McCabe NP, Madajka M, Vasanij A, and Byzova T.; Philadelphia, Pennsylvania, 2007
Investigating the Role of SPARC in bone metastatic prostate cancer, Poster Prese
ntation
McCabe NP, Madajka M, Vasanij A, and Byzova T.; AACR Annual Meeting, Los Angeles
, California, 2007
Direct Effect of Central Nitric Oxide on Intracellular Sodium in the Regulation
of Blood Pressure, Oral Presentation Madajka M, Bohr DF, and Malinski T.; Intern
ational Academy of Cardiology, Third World Congress on Heart Disease, Washington
, District of Columbia, 2003

PROFESSIONAL AFFILIATIONS
(2009-Present) Women’s Professional Staff Association, Cleveland Clinic, Cleveland,
Ohio
(2009) North America Scholar Consortium, member with high honors
(2008) American Association of the Advancement of Science (AAAS)
(2008) American Association for Clinical Chemistry (AACC)