NFTHM/IMS/Profile

National Facility for Tribal and Herbal Medicine

(Established and supported by DST, Govt. of India)
National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

Institute of Medical Sciences

Banaras Hindu University, Varanasi, India
http://www.imsbhu.ac.in

About Us
National Facility for Tribal and Herbal Medicine (NFTHM), IMS, BHU ha d been
established by DST, Govt. of India; for the r esearch and development of herbal drugs by
taking the lea ds from a ncient concept of India n S ystem of Medicine and from the indigenous
tribal medical knowledge.
For the establishment of this nationa l facility, DST awarded a national facility
project “Establishment of facilities for Identification, Chemical characterization,
Standardization and Quality Control of Medicinal Plants found in Tribal area in Central
India” by sanctioning 7.56 Crore, in January 2008.
The present national facility at BHU has been developed on the very unique principle
for global promotion of herbal and tribal formulations. The plan includes that entir e process
of drug development will not be done at single centre but work will be primarily have a
collaborative program wher e collection, identification a nd standardization may be done at one
centre, preclinical biological studies like acute, sub-acute and chronic toxicity at another
centre, the clinica l trial will be done by practitioner of moder n medicine (specialist and super
specialist of moder n parameters with well defined protocol). Subsequently, the verification
will be done by differ ent centre both in country and abroad. Probably, with this role model the
herbal and tribal for mulation can be established as a drug at global level in a ver y short time
with minimum budget.
Profile

The importance of medicinal plants in traditional healthcare practices, providing clues

to new areas of r esearch and in biodiversity conservation is now well recognized. However,
infor mation on the uses for pla nts for medicine is lacking from ma ny interior areas of tribal
area of central India. Keeping this in view and accounting the ongoing r esearch activities of
Banaras Hindu University in the field of tribal and ayurvedic medicine r esearch thr ough
BHU-UGC centr e for the last more than 15 years, the present National Facility for Tribal &
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Herbal Medicine has been established at Institute of Medical Sciences, BHU in 2008 by the
Department of Science & Technology, Govt. of India.
National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

The national facility has been established for identification, chemical

characterization, standardization and quality control of medicinal plants found in tribal areas
of this part of country. The biological standardization of herbal for mulations for their
therapeutic potential includes preclinical and clinical studies. Under current phase, the
facilities for the research a nd clinical trial studies on Tribal & Herbal for mulation for the
prevention & mana gement of neurodegenerative disor ders, sleep disorders, diabetes mellitus,
metabolic syndrome, obesity, menopausal syndrome have been established and the clinical
trial studies as per ethical and regulatory nor ms are under progr ess.

Objectives of the National Facility

1. To conduct r esearch for evaluation of therapeutic efficacy of Tribal Plants found in Central
India.

2. To carry out identification, chemical characterization, standardization and quality control of

medicinal plants found useful in differ ent disor ders such as cardiovascular, type-2 diabetes
mellitus, neurodegenerative disorders, menopause etc.

3. To develop new investigational drug for clinical conditions taking leads from Tribal medical
knowledge system.

4. To protect Intellectual Property Rights generated out of Tribal leads

5. Promotion of Intellectual Property Rights (IPRs) generated out of research outcomes.

6. Global promotion of Tribal Medicine by regulatory acceptance.

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ORGANIZATION CHART OF THE NATIONAL FACILITY

National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

Vice Chancellor, BHU

Director, IMS, BHU

National Study
Qualit y Assurance Principle Investigator & Coordinator Director for mult i-
Director centric studies
Investigators

Operational Units of national facility

Neurodegenerative Drug Trial and Immuno Pathology Drug Qualit y Field Trial study
and Sleep Lab Unit Clinical Patho logy Laboratory Validat ion Unit Unit
Unit

OPDs Unit GCP complied Record and Qualit y Control Administrative

metabo lic ward Archival Unit Assurance Unit and control Unit

Advisory board of the National Facility

An advisory board has been constituted to look after the policy matter and guidelines
for the National facility which will be as follows:

1. Director, IMS Chairman

2. Dean, Faculty of Medicine Member

3. Dean, Faculty of Ayurveda Member

4. Dean, Faculty of Dental Sciences Member

5. Prof. G. P. Dubey, Former Dean, Faculty of Ayurveda

Study Director, Advisor & coordinator of the National Facility Member

6. Dr. A. Agrawal, Co-PI, Dy. Coordinator (N.F.) Member

7. Prof. B. N. Upadhyay, Co-PI, Dy. Coordinator (N.F.) Member

8. Prof. R. G. Singh, P.I., Coordinator (N.F.) Member

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Staff of the National Facility for Tribal and Herbal Medicine

National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

Dr. Satya Prakash,, M.Sc. Ph.D. Scientist

Contact: 9415812128, satya_res2004@yahoo.co.in

Dr. Praveen Kumar Singh, B.Sc., BAMS, Dip. Yoga (BHU) Medical Officer
Contact: 9415356798, praveensingh.bhu@gmail.com

Dr. Sushama Tiwari, M.D. Ph.D Medical Officer

Contact: 9415221538,

Rajeev Kumar Dubey, MCA Computer Programmer

Contact: 9307079491,

Papinder Singh, M.Tech. Junior Research Fellow

Minakshi Dwivedi, M.Sc. Junior Research Fellow

Contact: 9415389700

Abhishek Kumar, M.Sc. Junior Research Fellow

Contact: 8808466411

Shailja Singh Technical Assistant

Contact: 9450111223

Anil Kumar Pathak Technical Assistant

Contact: 9451587555

Naresh Kumar Mishra Technical Assistant

Contact: 9794013250

Neetu Gupta Technical Assistant

Contact: 9453359233

Sunil Kumar Dubey Data Entry Operator

Contact: 9452332924

Prakhar Mishra Lab Attendant

Peer Muhammad Field Attendant

Manoj Patel Animal Attendant

Rinku Singh Ward Sahayika

Dhananjay Kumar Srivastava Ward Sahayak

Mamta Safaiwali

Najim Safaiwala

Vishnu Safaiwala
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Unit -1 Neurodegenerative study and Sleep Laboratory

National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

In this unit various equipments especially for the electrophysiological investigations of the
patients (study subjects) ha ve been established. All the equipments are specific to the study
pertaining to the neurodegenerative study and for sleep disor der study. All the equipments are
established in the facility are as per GLP standards for the investigations.

The major equipments installed in the facility along with brief details are as below:

1. Neuroperfect plus (EMG-2000-1) - The unit is established to observe the various type of
cha nges in Ner ve C onduction velocity of body of study subjects. The data taken in the for m
of MNC V, SNCV, VEP, H-reflex etc provide the infor mation for the deter mination of neuro-
degeneration of study cases. The machine if fully computerized and software based for
functioning.

2. Sleepcare Polysomnography Machine (32 Channel) - Polysomnography is used in

diagnosing and treating ma ny sleep disorders, including neur ologic disor ders, movement
disor ders and importantly in the diagnosis of breathing disor ders during sleep (sleep apnea).
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National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

3. Multiparameter Monitor- To check the differ ent physical parameters of subjects such as
Pulse, BP, PaO2, Temp etc the facility is established.
4. Digital Me mory Scope - For checking the short time and long time memor y power, the
sma ll portable equipment is installed. The serial learning and pair ed learning progra m
installed in the instrument is being utilized to check the potential of study subjects. The easy
technique to check the memor y is available in this unit.
5. Transcranial Doppler Unit - Transcranial Doppler (TCD) is a test that measures the velocity
of blood flow through the brain's blood vessels. Used to help in the diagnosis of emboli,
stenosis, vasospasm from a subarachnoid hemorrha ge (bleeding fr om a ruptured aneur ysm),
and other problems, this relatively quick and inexpensive test is growing in popularity in the
United States. The equipment is fully computerized a nd software based ha ving data storage
potential.

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6. Attention Span apparatus - Attention span is the a mount of time that a person can
concentrate on a task without becoming distracted. For evaluating the attention potential the
National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

equipment is fully computerized and has feasibility to store the data for the studies.
7. TMT machine - To check the abnor malities and cha nges during the physical exertion the
machine records the data.

8. Computerised 32 channel EEG Analyzer (NV3200) - The machine measur es the brain
waves with help of 32 channels positioned on hea d of subject. The collected infor mation in
the for m of EEG graph of study subjects usually provide the neurodegenerative changes in
the brain. The machine is fully computerized and well equipped for data storage.
9. CDE machine- The unit is a n advance automated unit for the detection of several
electroma gnetic waves of neurons in the body.
10. ENG Machine- The unit is an advance automated unit for the detection of several
electroma gnetic waves of neurons in the body.
11. Computerised Brain map (CBM2009) - The machine is highly sensitive for the
electroma gnetic cha nges of human brain. 32 electrodes positioned on the head of subject
collect specific infor mation for development of Brain Maps like Voltage map, Frequency
map and EEG graphs. The biochemical changes in huma n brain due stress or other
responsible parameters can be visualized in the for m of changes in voltage map. The facility
is an important component of Neurodegenaraitive Study Unit.
12. Physiopac-4 Channel polygraph machine - Several of the electrophysiological
characteristics of the huma n body can be measured with this ma chine. The test available with
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this machine are Electro-cephalogram (EEG), Electro-myogram (EMG), Occipital frontalis

muscle action potential (ENG), Galvanic Skin Resistance (GSR), Pulse, Temperature etc. of
National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

study subjects. The machine is fully computerized and the r ecorded data of the patients are
automatically stor ed in the Unit.

Unit-2 Drug Trial & Clinical Pathology Lab

In this unit various equipments specific to the biochemical investigation, haematological

study and urine analysis of the cases are regularly being done on GLP principles. All the
equipments are specific to the study pertaining to the clinical pathology and are fully
automated. The quality controls of equipments are adequate to the r egulator y norms a nd are
as per the required standards. The major equipments installed in the facility along with brief
details are as below:

1. Fully Automated Biochemistry Analyzer (Cobas Integra 400/Roche) - The unit is

established to measure differ ent chemica ls and other characteristics in a number of biological
samples quickly. It is fully automated and proper ly quality controlled. These measured
biochemistry tests of blood and other fluids ma y be useful in the evaluation of therapeutic
potential of trial drugs.
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National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

TESTS AVIALABLE ON COBAS INTEGRA 400

ALBUMIN BCG ANTI-THROMBIN AST / SGOT PRIMADONE
III
AMMONIA APO-A CHOLINESTERASE PROCAINAMIDE
BIL-D APO-B CK PROPOXYPHENE
BIL-T C3c CK-MB QUINIDINE
CALCIUM C4 CK-NAC SALICYLATE
CHOLESTEROL HiCo CERULOPLASMIN GGT ISE Potassium
CO2-L CRP HS GLDH + (04593138190 BENZODIAZEPINES
-Cobas c pack multi)
CREATININE J CRP LATEX HBDH + (04593138190 BENZODIAZEPINES
-Cobas c pack multi)
CREATININE PLUS D-DIMER LDH CANNOBINOIDS
ETHANOL FERRITIN LIPASE COCAINE
FRUCTOSEAMINE HAPTOGLOBIN p-AMYLASE COCAINE II
GLUCOSE HK IgA a1 ACID ETHANOL
GLYCOPROTEIN
HbA1c IgG a1 ANTITRYPSIN LSD
HDL-C IgM a1 MICROGLOBULIN METHADONE
IRON KAPPA ALBUMIN-T TQ METHAQUALONE
LACTATE LAMBDA ANTI-STREPTOLYSIN OPIATES
LDL-C LPA LX ISE Sodium ISE Chloride
MAGNESIUM MYOGLOBIN CYCLOSPORINE II
PHOSPHORUS PRE-ALBUMIN CYSTATIN C
TG RF II DIGITOXIN
TOTAL PROTEIN sTfR DIGOXIN
UIBC TP UR / CSF GENTAMICIN
UREA TRANSFERRIN LIDOCAINE
URIC ACID TOTAL T4 MPA
ACP T-UPTAKE NAPA
ALP ACETAMINOPHEN PHENCYCLIDINE
ALTL / SGPT AMIKACIN PHENOBARBITAL
AMYLASE CARBAMAZEPINE PHENYTOIN
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2. Fully Automated 5 parts Haematology Analyzer (Celltac E) - The ha ematology a nalyser

National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

simultaneously measures 22 parameters including WBC 5- Part Differential. WBC, RBC and
Platelet are measured by electrica l resistance detection method. WBC is differ entiated in to
Neutrophil, Lymphocyte, Monocyte, Eosinophil a nd Basophil by light scatter techniqu e
(FLOW CYTOMETRY with laser).

TEST AVAILABLE ON HAEMATOLOGY 5 PARTS ANALYZER

HAEMOGLOBIN M CH
TLC MCHC
DLC PLATELET COUNT
NEUTROPHIL H CT
LYMPHOCYTE PCT
EIOSINOPHIL MPV
MONOCYTE PDW
BASOPHIL RDW
M CV RBC

3. Fully Automated ELISA (Evidence Investigator, CLIA) - The Randox unit had been
installed in the facility with a developed patented biochip array technology to enable the
simultaneous deter mination of a panel of analytes from a single test sa mple. The evidence
automated immunoassay analyser facilitates a ver y rapid thr oughput of test results per hour
(capacity >2000 tests/hour possible). A wide range of biochip panels are available to test
thyroid hor mones, cytokines, tumour markers, fertility hor mones and cardiac markers which
are generally specific to huma n diagnostics.

4. Fully Automated Urine Analyzer (Cobas U 411/Roche) - This analyser is based on the
principle of reflectance photometry. Test M calibration strips are used for the calibration of
the photometer unit of the a nalyser and for quality control use commercially available Urine
controls or other suitable control material wer e used. The unit is fully automated a nd well
ma intained for the required purpose.
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National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

SPECIFIC GRAVITY UROBILINOGEN

pH BILIRUBIN
NITRATE ERYTHROCYTE
PROTEIN COLOUR
GLUCOSE CLEARITY
KETONE LEUCOCYTE

5. Other supporting equipments like Autoclave, Centrifuge, Hot Air Oven, Water purification
equipment, deep freeze are installed in the unit.

Unit-3 Immuno-Pathology Laboratory

The Immuno-pathology Lab has been developed in collaboration with UGC Adva nced
Immunodiagnostic Centre of the Department of Pathology, IMS, BHU. The following major
equipments are procur ed and established under National facility for Tribal & Herbal Medicine
scheme-
1. ELISA Reader - ELISA rea der instrument is installed to do spectro-photometry in which
they emit light at one wave length, and measure the a mount of light absorbed and r eflected by
an object such as a protein. A spectrophotometer measur es ultraviolet and visible light.
Additionally, ELISA plate rea ders can also measure fluor escence and luminescence.
Chemical dyes fluoresce or emit one color or wavelength when exposed to light. The a mount
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of reflection, absorption and the color identify, and mea sure the amount of a substance.

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National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

2. Electrophoresis - Electrophoresis involves the separation of chemicals along a solid mediu m

in the pr esence of an applied potential differ ence. In electrophor esis, chemicals such as blood
proteins, DNA or inorga nic ions ca n be separated according to differ ences in their mass
and/or charge. The solid medium used in electrophoresis is usually a n agarose or
polyacryla mide gel.

3. -80 C, Deep Freezer - To stor e the blood sa mples and kits at low temperature the facility is
established.
4. Trinocular & Binocular Microscope - These advance micr oscope facilities are equipped
with PC to collect the ima ges of slides.
5. Cryostat Microtome - The facility is installed for sectioning of tissues at very low
temperature.
6. Immuno-fluorescent Microscope - This advance immune flor escent microscope facilities
are equipped with PC to collect the ima ges of slides.
7. Mini PCR - Polymerase chain r eaction unit is established in the lab to a mplify sma ll quantity
of DNA.
8. Real Time PCR - Real-time polymerase chain reaction, also called quantitative real time
polymerase chain reaction (Q-PCR/qPCR/qrt-PCR) or kinetic polymerase chain
reaction (KPCR), is a laboratory unit based on the PCR, which is used to a mplify and
simultaneously quantify a targeted DNA molecule. It enables both detection and
quantification (as absolute number of copies or r elative a mount when nor malized to DNA
input or additiona l nor malizing genes) of one or mor e specific sequences in a DNA sample.
9. Inverted Microscope - The instrument is another microscope for routine sa mple study.
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10. Cryo Centrifuge - The low temperature fully automated centrifuge is established in the
facility.
National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

11. Other instruments like Freeze, incubators, and other lab units are available in the facility.

Unit-4 Record and Archival Unit

As per regulatory r equir ement, this unit has been developed, wher e all the r ecords; case
sheets, register, releva nt documents etc. will be pr eserved. Hard copy and soft copy are also
being pr eserved for next 15 years as per r egulatory r equirement. In or der to ensure ther e is no
way that these recor ds are destroyed. All the r eleva nt SOPs are for archival records have been
developed.

Unit-5 Field Trial Unit

Field Trial Unit has been established and is in operation as per international r egulatory
requir ement with the following aspects-
 To conduct the epidemiological survey of the local population with
special r efer ence to health seeking behaviour, nutrition, common releva nt
disease and for screening of target patient for clinical trial.
 The unit is equipped with basic equipments like Height and weight
machine, skill, Blood Pressure Monitoring Machine, Anthropometric
tape, necessary furniture etc.
 The unit is supervised and guided by Head of The Department of
Community Medicine and Faculty of Medical statistics of the institute,
supported by field staff of the facility.
Till now they ha ve conducted field trial in and around Varanasi including rural and
urban area in addition to screening ca mp and door to door study.

This gr oup has also established regular field OPD’s on Wednesday of the week as per
the detailed below-

Every Saturday - at University field health ca mp at Sunderpur, Varanasi with joint

collaboration of Dept.of Community Medicine

Wednesday- a follow-up ca mp is being or ganized to review the patients.

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Few snaps at field site during camp and screening program

National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

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Unit- 6 Herbal Drug Quality Validation Unit

National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

As per regulatory requirement this unit is being developed for the a nalysis and r esearch for
the evaluation of marker compounds in herbal drugs (plants), their quality validation and
investigation of newer chemical entities in tribal and herbal plants. The objectives of the unit
is validation a nd recor d of raw drugs along with their pharmacognosy, collection and review
of literature from ancient to modern period related to drugs, management of the quality of
drugs. The exploration of tribal medical practices r esided in the rural and tribal communities
of this part of country is being done through visits in these areas and the practices are being
standardized for collection of traditional medical knowledge. The regular testing of trial
herbal for mulations is maintained and recorded. In addition to experimental setup the facility
of specific HPLC-PDA unit is in process of procur ement for the quantitative evaluation of
active principles of herbal drugs and for mulations.

Unit-7 GCP Complied Metabolic Ward and OPD Unit

GCP complied metabolic ward for proper observation of ser ious patients and study patients; a
joint collaborative metabolic ward is being developed in the ward of Department of
Nephrology, Sir Sunderlal Hospital, Banaras Hindu University. This ward will be fully
supported by Coronary Care Unit, Intensive Care Unit and Emergency back up of Sir
Sunder lal Hospital. The patients if requir ed are being admitted under Co-or dinator for definite
ma nagement.
For follow up, special O.P.D. has been started in Room No.219 from 08:00 AM to 2:30 PM
on every Monday, Tuesday, Wednesday, Thursday and in Ayurveda OPD in a week wher e in
addition to consultation, patients are investigated for the disorders and register ed in specific
clinical trial studies.
For follow up and recruitment of cases in differ ent group, special O.P.D. has been started in
Room No.219 from 08:00 AM to 2:30 PM on every Monday, Tuesda y, Wednesda y, Thursday
and in Ayur veda Kaya-chikkitsha, wher e in addition to consultation, patients are investigated,
register ed in specific clinical trial studies.

Unit-8 Quality Control Assurance Unit

As per GLP guidelines and Inter national r equir ements Quality Assurance is an important
aspect for any facility of clinical trial. In our National facility this is hea ded by a Quality
Assurance Dir ector and two expert assistants are wor king for QA. This unit is responsible for
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monitoring the activities of all levels both on schedule and off schedule. The detail working
protocol and SOPs for this unit has been developed.
National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

Achievements

Our group under the dyna mic lea dership of for mer director Prof. K.N. Udappa and for mer
Dea n, faculty of Ayurveda, Prof. G.P. Dubey ha ve done the pioneer ing work in the field of
herbal and tribal medicine in last three decades. Based on obser vational data, pre-clinical
anima l studies on toxicology, efficacy a nd safety profile of tribal and herbal formulations, our
group has got following patents national and inter national level. Out of mor e tha n 17
identified for mulations by our gr oup, the clinica l trial studies on four disor ders are under
process in current phase.

National and International patents -

i. Herbal pr eparation for ma nagement of cardiovascular and neurological
disor ders and to a process for the preparation ther e of EP Patent no.1569
666.
ii. Neur opsychiatric and cardiovascular complications among menopausal
women. Patent no. 851 DEL 2007.
iii. Prevention and ma nagement of cognitive decline among aged – Patent
no.715 DEL 2002.
iv. An herbal for mulation for the pr evention and ma nagement of potential
diabetes a nd a process for preparation ther eof – Patent no. 664 DEL 2002,
43 28.
v. An herbal preparation for the prevention and ma nagement of
hyperchlorosterolemia a nd hypertriglyceridemia and a process for
preparation ther eof – Patent no. 662 DEL 2002.
vi. An herbal for mulation for the treatment of arthritis – a process for the
preparation ther eof – Patent no. 317 DEL 2002.
vii. An herbal composition for the management of pre-menopausal syndr ome
and a process or preparation ther e of Patent no. 714 DEL 2002.
viii. Role of the combined for mulation “Salacia chinensis, Hippopha e
rhamnoides and Coccinia indica” in the pr evention and ma na gement of
type-II diabetes mellitus including its micro-vascular complications Patent
no. IN 2005/000223.
ix. Role of Hippopha e rha mnoides in the management of
hyperhomocysteinemia and other risk factors associated with coronary
heart disease. Patent no. 704 KOL 2006.
x. Clinical application of Salacia oblonga and its significa nce in the
prevention of micro-vascular complications in type-II diabetes mellitus
cases. Patent no. 314 CHE 2007.
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Future Plan of the National Facility

National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

1. Development of Research lab for Experimental studies: In the current phase, the
preclinical experimental studies for tribal for mulation are being done in collaborative
centres in India. In future progra m we have to establish a GLP Research Lab for
experimental studies under this National facility centre. For building component the
Dept. of AYUSH has given his consent.
2. GLP accreditation of established facilities by regulatory authorities: The
regulatory acceptance of drug development research is mandatory for global
promotion of tribal and herbal drug. The GLP accreditation of established facilities is
urgent and is under process.
3. Conduction of training program for GLP and Drug develop ment research of
Tribal Medicine: As per the DST recommendations the regular programs for training
for GLP and Tribal Drug Development will be conducted for exploration and
development of expertise.
4. Exploration of new investigational tribal and herbal drugs taking the leads from
existing knowledge in tribal community of central India: The Tribes of India have
preserved a rich national heritage in the for m of Tribal medicine. The tribal
populations, who have been the primary inhabitants of natural habitats, hold
tremendous a mount of traditional knowledge on the use of various biotic resources,
which ma y ha ve gr eater importance to the on-going r esearch and discoveries in the
field. The Tribes are living in a closed compact society and utilizing pla nts and
anima l materials found in their locality. The compilation of the traditional concepts
and the development of new for mulations after taking the lea ds from tribal medical
knowledge will be explor ed from this part of the country which will be certainly a
key ma ndate of this establishment.
5. Clinical Trial studies for the AYUSH ayurvedic formulation: The GLP and GCP
complied clinical trial studies will be undertaken by the National facility of known
AYUSH ayurvedic for mulation for regulatory global acceptance.
6. Area of collaboration and interest: These referral patients are open for all the
research workers and scientists who are working in the area of tribal and herbal
medicine to take advantage of facilities in developing tribal and herbal drug for global
promotion.
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Ongoing Clinical Trials in National Facility

National Facility for Tribal and Herbal Medicine, Institute of Medical Sciences, Banaras Hindu University

Presently in the national facility four IPR protected herbal formulations are being evaluated
for their potential and for their biological standardization. The for mulations are for prevention
and ma nagement of
 Age related Neurodegeneration
 Menopausal syndrome
 Metabolic syndrome
 Obesity
The patients are being included in the study after getting infor med consent in writing.
Patients are provided free investigations and drug for the whole period of follow up.
On follow up, patients are provided travel expenditure from clinical site.
The patients are convinced for the treatment of all the elements of side effect and adverse
effect of the drug.
Patient can report dir ectly to the national facility clinic as may be referred by doctor/hospital.

Feedback

The forth infor mation about the national facility ca n be get fr om Prof. R.G. Singh (PI & Co-
ordinator), Dr. Aruna Agrawal (Co-PI)
Prof. R.G. Singh,
PI and Co-ordinator,
Head, Department of Nephrology, Institute of Medical Sciences
Banaras Hindu University, Varanasi 221 005, UP India
E-Mail: profrgsingh@yahoo.com, rgsingh@bhu. ac.in
Contact: (O) 91-542- 2369938, (R) 91-542-2369936, (M) 91-9839080939

…and with following members:

Dr. Praveen Singh
Dr. Sushma Tiwari
Dr. Satya Prakash
Mr. Rajeev kumar Dubey
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