SwissTargetPrediction

Target Common Uniprot ChEMBL ID Target Class Probability* Known

name ID actives
(3D/2D)
GABA receptor GABRA1 P14867 CHEMBL1962 Ligand-gated ion 0.104671941128 32 / 0     
alpha-1 subunit (by channel
homology)
GABA receptor GABRA5 P31644 CHEMBL5112 Ligand-gated ion 0.104671941128 29 / 0     
alpha-5 subunit (by channel
homology)
Translocator protein TSPO P30536 CHEMBL5742 Membrane 0.104671941128 510 / 0     
(by homology) receptor
Histamine H3 HRH3 Q9Y5N1 CHEMBL264 Family A G protein- 0.104671941128 95 / 0     
receptor coupled receptor
Neuropeptide Y NPY5R Q15761 CHEMBL4561 Family A G protein- 0.104671941128 291 / 0     
receptor type 5 coupled receptor
Vascular endothelial KDR P35968 CHEMBL279 Kinase 0.104671941128 524 / 0     
growth factor receptor
2
Purinergic receptor P2RY1 P47900 CHEMBL4315 Family A G protein- 0.104671941128 27 / 0     
P2Y1 coupled receptor
MAP kinase p38 alpha MAPK14 Q16539 CHEMBL260 Kinase 0.104671941128 689 / 0     
Cytochrome P450 CYP19A1 P11511 CHEMBL1978 Cytochrome P450 0.104671941128 321 / 0     
19A1
Cyclooxygenase-2 PTGS2 P35354 CHEMBL230 Oxidoreductase 0.104671941128 397 / 0     
Serine/threonine- RAF1 P04049 CHEMBL1906 Kinase 0.104671941128 74 / 0     
protein kinase RAF
Isocitrate IDH1 O75874 CHEMBL2007625 Enzyme 0.104671941128 308 / 0     
dehydrogenase
[NADP] cytoplasmic
Hormone sensitive LIPE Q05469 CHEMBL3590 Enzyme 0.104671941128 73 / 0     
lipase
Acid ceramidase ASAH1 Q13510 CHEMBL5463 Enzyme 0.104671941128 24 / 0     
Cyclin-dependent CDK5 Q00535 CHEMBL4036 Kinase 0.104671941128 39 / 0     
kinase 5/CDK5
activator 1
Tyrosine-protein JAK3 P52333 CHEMBL2148 Kinase 0.104671941128 268 / 0     
kinase JAK3
Tyrosine-protein JAK2 O60674 CHEMBL2971 Kinase 0.104671941128 299 / 0     
kinase JAK2
N-acylsphingosine- NAAA Q02083 CHEMBL4349 Enzyme 0.104671941128 74 / 0     
amidohydrolase (by
homology)
Phosphodiesterase PDE10A Q9Y233 CHEMBL4409 Phosphodiesterase 0.104671941128 918 / 0     
10A
Epoxide hydratase EPHX2 P34913 CHEMBL2409 Protease 0.104671941128 293 / 0     
Focal adhesion kinase PTK2 Q05397 CHEMBL2695 Kinase 0.104671941128 82 / 0     
1
Orexin receptor 2 HCRTR2 O43614 CHEMBL4792 Family A G protein- 0.104671941128 619 / 0     
coupled receptor
Orexin receptor 1 HCRTR1 O43613 CHEMBL5113 Family A G protein- 0.104671941128 503 / 0     
coupled receptor
Trace amine- TAAR1 Q96RJ0 CHEMBL5857 Family A G protein- 0.104671941128 145 / 0     
associated receptor 1 coupled receptor
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
Adenosine A1 ADORA1 P30542 CHEMBL226 Family A G protein- 0.104671941128 711 / 0     
receptor (by coupled receptor
homology)
Leukocyte elastase ELANE P08246 CHEMBL248 Protease 0.104671941128 218 / 0     
11-beta- HSD11B1 P28845 CHEMBL4235 Enzyme 0.104671941128 468 / 0     
hydroxysteroid
dehydrogenase 1
Phosphodiesterase PDE5A O76074 CHEMBL1827 Phosphodiesterase 0.104671941128 251 / 0     
5A
Potassium- ATP4B P51164 CHEMBL2095173 Primary active 0.104671941128 32 / 0     
transporting ATPase ATP4A P20648 transporter
FK506-binding protein FKBP1A P62942 CHEMBL1902 Isomerase 0.104671941128 94 / 0     
1A
Serine/threonine- PIM1 P11309 CHEMBL2147 Kinase 0.104671941128 151 / 0     
protein kinase PIM1
Serine/threonine- PIM2 Q9P1W9 CHEMBL4523 Kinase 0.104671941128 93 / 0     
protein kinase PIM2
Transient receptor TRPM8 Q7Z2W7 CHEMBL1075319 Voltage-gated ion 0.104671941128 29 / 0     
potential cation channel
channel subfamily M
member 8 (by
homology)
Monoamine oxidase B MAOB P27338 CHEMBL2039 Oxidoreductase 0.104671941128 478 / 0     
Tankyrase-2 TNKS2 Q9H2K2 CHEMBL6154 Enzyme 0.104671941128 73 / 0     
Monoamine oxidase A MAOA P21397 CHEMBL1951 Oxidoreductase 0.104671941128 246 / 0     
Serine/threonine- BRAF P15056 CHEMBL5145 Kinase 0.104671941128 103 / 0     
protein kinase B-raf
Serine/threonine- TNNI3K Q59H18 CHEMBL5260 Kinase 0.104671941128 44 / 0     
protein kinase
TNNI3K
GABA-A receptor; GABRB3 P28472 CHEMBL2094120 Ligand-gated ion 0.104671941128 230 / 0     
alpha-3/beta-3/ GABRA3 P34903 channel
gamma-2 GABRG2 P18507
GABA-A receptor; GABRB3 P28472 CHEMBL2094121 Ligand-gated ion 0.104671941128 204 / 0     
alpha-1/beta-3/ GABRG2 P18507 channel
gamma-2 GABRA1 P14867
GABA-A receptor; GABRB3 P28472 CHEMBL2094122 Ligand-gated ion 0.104671941128 261 / 0     
alpha-5/beta-3/ GABRG2 P18507 channel
gamma-2 GABRA5 P31644
GABA-A receptor; GABRA2 P47869 CHEMBL2094130 Ligand-gated ion 0.104671941128 202 / 0     
alpha-2/beta-3/ GABRB3 P28472 channel
gamma-2 GABRG2 P18507
GABA-A receptor; GABRA1 P14867 CHEMBL2095172 Ligand-gated ion 0.104671941128 30 / 0     
alpha-1/beta-2/ GABRB2 P47870 channel
gamma-2 GABRG2 P18507
Histamine H4 HRH4 Q9H3N8 CHEMBL3759 Family A G protein- 0.104671941128 62 / 0     
receptor coupled receptor
Metabotropic GRM2 Q14416 CHEMBL5137 Family C G protein- 0.104671941128 79 / 0     
glutamate receptor 2 coupled receptor
Corticotropin CRHR1 P34998 CHEMBL1800 Family B G protein- 0.104671941128 316 / 0     
releasing factor coupled receptor
receptor 1
Cyclooxygenase-1 PTGS1 P23219 CHEMBL221 Oxidoreductase 0.104671941128 99 / 0     
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
Caspase-3 CASP3 P42574 CHEMBL2334 Protease 0.104671941128 105 / 0     
Serine/threonine- PLK1 P53350 CHEMBL3024 Kinase 0.104671941128 28 / 0     
protein kinase PLK1
G-protein coupled bile GPBAR1 Q8TDU6 CHEMBL5409 Family A G protein- 0.104671941128 37 / 0     
acid receptor 1 coupled receptor
Vascular endothelial FLT1 P17948 CHEMBL1868 Kinase 0.104671941128 133 / 0     
growth factor receptor
1
Metabotropic GRM4 Q14833 CHEMBL2736 Family C G protein- 0.104671941128 103 / 0     
glutamate receptor 4 coupled receptor
Metabotropic GRM5 P41594 CHEMBL3227 Family C G protein- 0.104671941128 921 / 0     
glutamate receptor 5 coupled receptor
Dihydroorotate DHODH Q02127 CHEMBL1966 Oxidoreductase 0.104671941128 36 / 0     
dehydrogenase
Muscarinic CHRM2 P08172 CHEMBL211 Family A G protein- 0.104671941128 61 / 0     
acetylcholine receptor coupled receptor
M2 (by homology)
Muscarinic CHRM1 P11229 CHEMBL216 Family A G protein- 0.104671941128 105 / 0     
acetylcholine receptor coupled receptor
M1 (by homology)
Dual-specificity DYRK1A Q13627 CHEMBL2292 Kinase 0.104671941128 90 / 0     
tyrosine-
phosphorylation
regulated kinase 1A
(by homology)
Muscarinic CHRM3 P20309 CHEMBL245 Family A G protein- 0.104671941128 98 / 0     
acetylcholine receptor coupled receptor
M3 (by homology)
Adenosine A2a ADORA2A P29274 CHEMBL251 Family A G protein- 0.104671941128 524 / 0     
receptor (by coupled receptor
homology)
c-Jun N-terminal MAPK9 P45984 CHEMBL4179 Kinase 0.104671941128 89 / 0     
kinase 2
Proto-oncogene MERTK Q12866 CHEMBL5331 Kinase 0.104671941128 6 / 0     
tyrosine-protein
kinase MER
Nuclear receptor ROR- RORC P51449 CHEMBL1741186 Nuclear receptor 0.104671941128 74 / 0     
gamma
Bile acid receptor FXR NR1H4 Q96RI1 CHEMBL2047 Nuclear receptor 0.104671941128 38 / 0     
Beta secretase 2 BACE2 Q9Y5Z0 CHEMBL2525 Protease 0.104671941128 44 / 0     
Adenosine A3 ADORA3 P0DMS8 CHEMBL256 Family A G protein- 0.104671941128 425 / 0     
receptor coupled receptor
LXR-alpha NR1H3 Q13133 CHEMBL2808 Nuclear receptor 0.104671941128 40 / 0     
Nuclear receptor ROR- RORB Q92753 CHEMBL3091268 Nuclear receptor 0.104671941128 6 / 0     
beta
Pregnane X receptor NR1I2 O75469 CHEMBL3401 Nuclear receptor 0.104671941128 14 / 0     
LXR-beta NR1H2 P55055 CHEMBL4093 Nuclear receptor 0.104671941128 36 / 0     
Nuclear receptor ROR- RORA P35398 CHEMBL5868 Nuclear receptor 0.104671941128 5 / 0     
alpha
Epoxide hydrolase 1 EPHX1 P07099 CHEMBL1968 Protease 0.104671941128 103 / 0     
Adenosine A2b ADORA2B P29275 CHEMBL255 Family A G protein- 0.104671941128 104 / 0     
receptor coupled receptor
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
Metabotropic GRM1 Q13255 CHEMBL3772 Family C G protein- 0.104671941128 76 / 0     
glutamate receptor 1 coupled receptor
Hexokinase type IV GCK P35557 CHEMBL3820 Enzyme 0.104671941128 104 / 0     
Tankyrase-1 TNKS O95271 CHEMBL6164 Enzyme 0.104671941128 59 / 0     
Cytochrome P450 CYP11B1 P15538 CHEMBL1908 Cytochrome P450 0.104671941128 194 / 0     
11B1
Carbonic anhydrase CA7 P43166 CHEMBL2326 Lyase 0.104671941128 81 / 0     
VII
Tyrosine-protein LCK P06239 CHEMBL258 Kinase 0.104671941128 166 / 0     
kinase LCK
Kir3.1/Kir3.4 KCNJ5 P48544 CHEMBL3038488 Voltage-gated ion 0.104671941128 37 / 0     
KCNJ3 P48549 channel
Kir3.1/Kir3.2 KCNJ6 P48051 CHEMBL3038489 Voltage-gated ion 0.104671941128 40 / 0     
KCNJ3 P48549 channel
Carbonic anhydrase CA12 O43570 CHEMBL3242 Lyase 0.104671941128 242 / 0     
XII
Carbonic anhydrase CA14 Q9ULX7 CHEMBL3510 Lyase 0.104671941128 52 / 0     
XIV
Phosphodiesterase PDE4D Q08499 CHEMBL288 Phosphodiesterase 0.104671941128 43 / 0     
4D
Cholecystokinin B CCKBR P32239 CHEMBL298 Family A G protein- 0.104671941128 224 / 0     
receptor (by coupled receptor
homology)
DNA polymerase POLA1 P09884 CHEMBL1828 Transferase 0.104671941128 3 / 0     
alpha subunit
Glycogen synthase GSK3B P49841 CHEMBL262 Kinase 0.104671941128 264 / 0     
kinase-3 beta
PI3-kinase p110-delta PIK3CD O00329 CHEMBL3130 Enzyme 0.104671941128 79 / 0     
subunit
Bromodomain- BRD4 O60885 CHEMBL1163125 Reader 0.104671941128 96 / 0     
containing protein 4
Bromodomain- BRD2 P25440 CHEMBL1293289 Reader 0.104671941128 33 / 0     
containing protein 2
Bromodomain testis- BRDT Q58F21 CHEMBL1795185 Reader 0.104671941128 3 / 0     
specific protein
Bromodomain- BRD3 Q15059 CHEMBL1795186 Reader 0.104671941128 38 / 0     
containing protein 3
Butyrylcholinesterase BCHE P06276 CHEMBL1914 Hydrolase 0.104671941128 92 / 0     
Alpha-1d adrenergic ADRA1D P25100 CHEMBL223 Family A G protein- 0.104671941128 32 / 0     
receptor coupled receptor
Alpha-1a adrenergic ADRA1A P35348 CHEMBL229 Family A G protein- 0.104671941128 59 / 0     
receptor coupled receptor
Alpha-1b adrenergic ADRA1B P35368 CHEMBL232 Family A G protein- 0.104671941128 24 / 0     
receptor coupled receptor
Short transient TRPC6 Q9Y210 CHEMBL2417347 Voltage-gated ion 0.104671941128 22 / 0     
receptor potential channel
channel 6
Short transient TRPC3 Q13507 CHEMBL2417348 Voltage-gated ion 0.104671941128 20 / 0     
receptor potential channel
channel 3
Serine/threonine- STK17B O94768 CHEMBL3980 Kinase 0.104671941128 11 / 0     
protein kinase 17B
 Target Common Uniprot ChEMBL ID Target Class Probability* Known
name ID actives
(3D/2D)
P2X purinoceptor 7 P2RX7 Q99572 CHEMBL4805 Ligand-gated ion 0.104671941128 331 / 0     
channel
Transitional VCP P55072 CHEMBL1075145 Primary active 0.104671941128 58 / 0     
endoplasmic transporter
reticulum ATPase