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RESEARCH ARTICLE
ABSTRACT:
Pre –eclampsia is a condition that cause complications in pregnancy such as preterm delivery, low weight babies and
perinatal death. This study therefore was aimed at evaluating the occurrence and associated risk factors of pre –
eclampsia amongst pregnant women in their third trimester of gestation. A cross – sectional hospital based design
involving 160 randomly selected pregnant women. Data on demographic and risk factors were collected using a well –
structured pretested questionnaire while proteinuria and blood pressure were determined using combi – 2 dip strip and
sphygmomanometer respectively. Data was analyzed using SPSS version 17. From the results obtained, the prevalence
of pre – eclampsia was shown to be 6.3% and the predisposing risk factors were maternal age, body mass index, past
history of pre – eclampsia, family history of diabetes mellitus, family history of hypertension, husbands age, paternity
and work stress. In conclusion, the occurrence of pre – eclampsia was high with the most important risk factors being
maternal age ≥ 35 years, family history of hypertension and past history of pre – eclampsia.
health center Nkwen located in the North West Region of Table 1: Demography of the study population
Cameroon. This hospital was selected because it has an Variable %(n)
antenatal clinic and a well – constructed laboratory. Age groups (years) 14-20 11.3(18)
21-27 50.6(81)
28-34 24.4(39)
Study Population: 35-41 13.1(21)
A total of 160 pregnant women in their 3rd trimester who 42-48 0.6(1)
accepted to participate were randomly selected to take part Occupation Students 28.8(46)
in the study. Teachers 18.1(29)
Farmer 3.8(6)
Traders 22.5(36)
Data Collection: Medical personnel 4.4(7)
A pre – tested well-structured questionnaire composed of Others 22.5(36)
open and closed ended questions was used to collect Level of Education Primary 13.8(22)
demographic and clinical data from the participants. Secondary 62.5(100)
University 23.1(37)
None 0.6(1)
Sample Collection:
The pregnant women who were randomly selected were
Distribution of some risk factors for pre – eclampsia:
given sterile wide – neck leak proof urine containers to
The prevalent risk factors identified in this study were
collect a clean catch mid – stream urine sample which were
family history of hypertension (18.1%), past history of pre –
tested immediately.
eclampsia (15.6%), maternal age ≥ 35 years (13.6%),
obesity (7.5%) and family history of diabetes mellitus
Determination of Proteinuria:
(5.6%). There are consistent findings of a positive
Proteinuria was determined using combi–2 strips
association between family history of diabetes and
(CYBOW) as follows; the strip was dipped into the freshly
hypertension and pre – eclampsia risk (Siddigi et al., 1991).
collected urine sample and the results read by comparing
Family history of hypertension is a proxy measure of
with a standard chart from manufacturer.
hereditary factors as well as common environment or
behavioral exposures that may underline pre – eclampsia
Determination of Blood Pressure:
risk (Caren and Solomon, 2001).
Blood pressure was taken using a sphygmomanometer.
Also husband’s age ≥ 40 years (37.6%) and primiparternity
Data Analysis:
(6.3%) and work stress (9.4%) were found to be the
The data collected were analyzed using SPSS version 17
pregnancy associated risk factors for pre – eclampsia.
and results represented on tables.
Harlap et al., 2002 reported that the risk of pre – eclampsia
was 24% higher if men were 35 – 44 years and 80% if they
Ethical considerations:
were 45 years and older. The term primiparternity (change
An informed consent form was attached to each
in partner) was introduced by Robillard and Husley (1996).
questionnaire so that each participant signed the consent
According to this theory, pre – eclampsia may be a problem
form before participating. Full confidentiality and
of primiparternity rather than primigravidity. Many studies
participants rights were maintained. Authorization for the
have shown that change in partner raises the risk for pre –
study was sought from the North West Regional Delegation
eclampsia in subsequent pregnancies (Odegard et al., 2000).
of Public Health and from the Medical officer of the
Bamenda sub – divisional Medicalized health center
Distribution of pre–eclampsia based on some risk
Nkwen.
factors:
From the distribution of pre – eclampsia based on some risk
RESULTS AND DISCUSSION: factors, most of the positive cases were within the age range
Prevalence of pre – eclampsia: of 14 – 20 years (1.9%) and 35 – 41 years (1.9%). Some
Out of the 160 pregnant women who participated in this studies have reported the association between age and pre –
study, 10 were positive for pre–eclampsia giving a eclampsia especially in pregnant elderly women above the
prevalence of 6.3%. This prevalence is slightly higher age of 35 years while others have shown an association of
compared to the findings of Agustin and José (1999) who pre – eclampsia with younger age groups. Thus advancing
reported a 4.8% prevalence of pre – eclampsia in Latin maternal age as well as young maternal age is a risk factor
America and Caribbean. for pre – eclampsia (Duckitt and Harrington, 2005). Also,
Mostello et al., 2002 reported that a high proportion of pre
Demographic presentation of the study population: – eclampsia cases occur in those at the extreme ends of the
From the results, most of the participants were within the productive age. These reports are consistent to the results
age range of 21 – 27 years (50%) and were mostly students obtained in this study.
(28.8%) with most of them having secondary level as their
highest level of education (62.5%). This could be explained Also based on occupation (work), most of the positive cases
by the fact that most of the participants were students who were found amongst teachers (1.9%) followed by farmers
were still struggling to update their academic profile. (1.3%) and traders (1.3%). This is similar to the
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Research Journal of Pharmacology and Pharmacodynamics. 6(4): October-December, 2014, 190-192
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