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FAIXXX10.1177/1071100715607619Foot & Ankle InternationalÇelik et al
Article
Foot & Ankle International®
Study
Derya Celik, PhD1, Gamze Kuş, MSc, PT2, and Serkan Önder Sırma, MD3
Abstract
Background: This study compared the effectiveness of joint mobilization combined with stretching exercises (JM&Str) vs
steroid injection (SI) in the treatment of plantar fasciitis (PF).
Methods: A total of 43 patients (mean age, 45.5 ± 8.5 years; range, 30-60 years; 23 females) with PF were randomly
assigned to receive either JM&Str (n = 22) or SIs (n = 21). JM&Str was applied 3 times per week for 3 weeks for a total of 9
visits. The SI group received 1 injection at baseline. The patients’ functional scores were assessed using the Foot and Ankle
Ability Measure (FAAM), and pain was evaluated using the Visual Analog Scale (VAS). Outcomes of interest were captured
at baseline and at 3-week, 6-week, 12-week, and 1-year follow-ups. The primary aim was examined using a mixed-model
analysis of variance (ANOVA). Pairwise comparisons were performed to examine differences between the baseline and
follow-up periods using Bonferroni equality at an alpha level of 0.05.
Results: Age, sex, body mass index, and dorsiflexion range of motion did not significantly impact pain relief or functional
outcome (P > .05) at the 3-, 6- or 12-week follow-ups compared to baseline. Planned pairwise comparisons demonstrated
significant improvements in pain relief and functional outcomes in both groups (P < .05) at the 3-, 6-, and 12-week follow-
ups compared to baseline. However, at the 12-week and 1-year follow-ups, pain and functional outcomes were significantly
improved in only the JM&Str group (P = .002). The overall group-by-time interaction was statistically significant for both
FAAM (P = .001; F = 7.0) and VAS (P = .001; F = 8.3) scores. Between-group differences favored the SI group at the 3-week
(P = .001, P = .001), 6-week (P = .002, P = .001), and 12-week (P = .008, P = .001) follow-ups for pain relief and functional
outcomes. However, no significant differences (P = .62, P = .57) were detected in the measured outcomes at the 1-year
follow-up.
Conclusion: Our study demonstrated that while both groups achieved significant improvements at the 3-, 6-, and 12-
week follow-ups, the SI group exhibited better outcomes at all 3 time points. The noted improvements continued in only
the JM&Str group for a period of time ranging from 12 weeks to 1 year.
Level of Evidence: Level II, comparative study.
Keywords: exercise therapy, manual therapy, fascia, pain management, foot pain
Methods
Study Design
A prospective, single-blinded, randomized, controlled trial Figure 1. Flow chart of the study design.
was performed at the Orthopedics and Traumatology Clinic
between October 2012 and December 2013. All of the
patients who agreed to participate in the study signed a writ- required patients to have a point of maximal tenderness on
ten informed consent form, which was approved by the eth- clinical examination over the medial tubercle of the calca-
ics committee. neus, pain with palpation of the proximal insertion of the
plantar fascia, heel pain during weight-bearing activity, a
negative tarsal tunnel test, and a positive windlass test.
Participants
Patients with potential arthritis, fractures, tumors of the foot
Forty-three (average age, 46 years; range, 30-60 years; 23 or ankle, rheumatoid arthritis, generalized polyarthritis sero-
females) patients with PF were randomly assigned to either negative arthropathy, neurologic impairments, or extremity
the JM&Str (n = 22) group or the SI (n = 21) group (Figure 1). nerve entrapment were excluded. Patients with prior surgery
The sample size was evaluated and power calculations were to the distal tibia, fibula, ankle joint or rear foot region
performed using an Instat sample size calculator. The calcu- (proximal to the base of the metatarsals) or with fractures or
lations were based on a standard deviation of 6.9 points other absolute contraindications to manual therapy that led
based on the FAAM-ADL score, with a between-group dif- to the prior use of corticosteroids or other therapy were also
ference of 8 points20 (which represented the minimal clini- excluded.
cally important difference [MCID] in FAAM-ADL score), None of the evaluated baseline characteristics, including
an alpha level of 0.05, and a β level of 20% at a desired age, gender, duration of symptoms, body mass index (BMI),
power of 80%. These parameters generated a sample size of and dorsiflexion range of motion, were significantly different
at least 12 patients per group. We recruited 43 patients into between the 2 groups (P > .05) (Table 1). Two patients dropped
the study to allow for dropouts. Patients with unilateral PF out of the JM&Str group: one patient during the intervention
were screened for eligibility criteria. The inclusion criteria period and the other patient after the intervention period. Two
Figure 3. (A) Subtalar lateral glide. (B) First tarsometatarsal Steroid Injection Group. Each patient was placed in a supine
joint dorsal glide. position. A medial approach was used for injection adminis-
tration. The injection was usually applied at the point of max-
imal tenderness on palpation.14 The most painful site of the
medial aspect of the heel was identified by palpation. Proper
preparation was performed by applying an antiseptic solution
to the skin overlying the injection point. Subsequently, either
1 mL of corticosteroid (40 mg methylprednisolone acetate)
or 4 mL of 2% prilocaine hydrochloride was injected using a
22-gauge needle. Each injection was administered into the
heel around the plantar fascia. The same physician adminis-
tered all of the injections. Each injection was administered
once at baseline. No calf stretching was performed.
Table 2. A Comparison of Repeated Measures of FAAM and VAS Between Groups.
Repeated
Baseline Mean 3-wk Mean 6-wk Mean 12-wk Mean 12-mo Mean Measures
Assessments Group ± SD ± SD ± SD ± SD ± SD F ANOVA
VAS JM&Str 7.8 ± 1.6 5.4 ± 2.8 5.0 ± 2.3 4.9 ± 2.4 2.7 ± 3.2 .001
SI 7.7 ± 1.5 1.8 ± 2.1 1.2 ± 1.4 1.5 ± 1.9 3.3 ± 3.2 8.30
P value* .84 .001 .001 .001 .57
FAAM JM&Str 55.2 ± 18.4 60.6 ± 14.4 70.2 ± 17.5 69.4 ± 16.8 86.7 ± 21.9 .001
SI 45.5 ± 17.6 80.7 ± 19.4 85.7 ± 11.2 83.5 ± 14.6 83.4 ± 17.3 7.00
P value* .09 .001 .002 .008 .62
ANOVA, analysis of variance; FAAM, Foot and Ankle Ability Measure; JM&Str, Joint Mobilization & Stretching; SD, standard deviation; VAS, visual
analog scale.
*Independent sample t test.
only significant in the JM&Str group (P = .002). The overall in pain and function after a single session of joint mobiliza-
group-by-time interaction was statically significant based on tion combined with stretching exercises.31 The most com-
both FAAM (P = .001; F = 7.0) and VAS (P = .001; F = 8.3) prehensive study to date was performed by Cleland et al,4
scores. The between-group differences favored the SI group at who applied soft tissue mobilization and joint mobilization,
the 3-week (P = .001, P = .001), 6-week (P = .002, P = .001), including high-velocity, low-amplitude thrust and manipu-
and 12-week (P = .008, P = .001) follow-ups for pain and lation and mobilization techniques to the ankle, foot, inter-
function; however, no significant differences (P = .62, P = tarsal joint and upper joint. The authors reported that manual
.57) were detected in these outcomes at the 1-year follow-up. physical therapy and exercise were superior to electrophysi-
cal agents and exercise in managing patients with PF in
terms of pain and function.4 Our study did not use soft tis-
Discussion sue mobilization or thrust and manipulation techniques. We
The results of our study demonstrated that both groups primarily focused on pain rather than dorsiflexion restric-
achieved significant improvements at 3, 6, and 12 weeks of tion, which was not significantly different between groups.
follow-up. However, these improvements continued in only We only applied Grade I and II talocrural, subtalar and tar-
the JM&Str group for a period of 12 weeks to 1 year. The sometatarsal joint mobilization and stretching exercises.
results also suggest that the treatment approach in the SI Our short-term results revealed that the JM&Str group was
group provided greater clinical benefits in terms of function not superior to the SI group based on FAAM and VAS scor-
and pain than those experienced by the JM&Str group at the ing and that the 2 groups were not significantly different at
follow-up periods ranging from 3 weeks to 12 weeks. 1-year follow-up. However, the JM&Str group exhibited
However, the superiority of SI was not maintained at the continued improvements between 12 weeks and 1 year,
1-year follow-up, as a significant difference was no longer although these improvements did not lead to between-group
found for this effect (Table 2). These results support that SI differences in pain or function.
provides remarkable short-term pain relief and functional Several studies have recommended the use of calf
improvement. Although not significant, the results also sug- stretching for the treatment of PF.9,24,31 Calf muscle and/or
gest that JM&Str is a promising treatment method of plantar fascia–specific stretching may provide short-term
achieving longer-term improvements in pain and function, pain relief and improvements in calf-muscle flexibility.
as evidenced by the 1-year follow-up data. A set of clinical Evidence from 2 systematic reviews suggests that stretch-
practice guidelines published in 2008 that focused on the ing the soft tissue around the ankle and foot provides short-
management of patients with PF concluded that only mini- term clinical benefits to individuals with PF.16,29 Many
mal evidence suggested that manual therapy was effective studies have attempted to delineate how and what to stretch
for managing PF.22 However, these guidelines were revised for the treatment of PF.9,19,24,29 It appears that there are no dif-
in 2014 to recommend that clinicians use manual therapy ferences between the results obtained from sustained vs inter-
consisting of soft tissue and joint mobilization to decrease mittent stretching techniques9 and that calf stretching may be
pain and improve function in patients with plantar heel more effective than plantar fascia–specific stretching24 in
pain.19 However, “manual therapy” includes many tech- improving plantar fascia flexibility. The present study used
niques, such as joint mobilization and manipulation, neu- a method of sustained stretching in which patients were
ral mobilization, myofascial trigger point manipulation, instructed to hold each stretch for a count of 30, to repeat
and soft tissue mobilization.5,6,15,23,25 A case series by Yong the stretch 10 times, and to perform these stretching exer-
et al reported that patients experienced rapid improvements cises 3 times daily for 3 weeks (9 visits). We also used
plantar fascia–specific stretching because the Achilles ten- It reinforced what many clinicians have found in their clinics; ste-
don and plantar fascia are continuous connective tissue. roid injections can lead to good temporary relief of plantar heel
Steroid injection is commonly used to treat PF. There is pain. It would have been more helpful to recommend that steroid
some evidence that injected corticosteroids are effective in injection group perform calf stretching exercises but the study
nicely documented the time course of relief following these injec-
providing temporary pain relief.8 The rapid effects of SI on
tions. It also demonstrated the effectiveness of stretching com-
pain encourages its frequent use by clinicians in treating PF,
bined with a joint mobilization program. It would have been
particularly in professional athletes who must quickly interesting to compare the effectiveness of stretching vs stretching
return to their livelihood. However, current scientific evi- and joint mobilization to assess the added effect of the joint mobi-
dence indicates that SI should not be used to treat PF in lization. Perhaps this can be the subject of a future study.
athletes because of its greater risk of causing spontaneous
rupture.18 Previous studies have shown that SI is most ben- Declaration of Conflicting Interests
eficial in treating PF-associated pain and swelling between The author(s) declared no potential conflicts of interest with respect
4 and 12 weeks.2,21 Similar to the aforementioned studies, to the research, authorship, and/or publication of this article.
we found that SI was superior to JM&Str in the short term,
but no differences were observed in the long-term effects of Funding
the 2 treatment modalities. Although we confirmed our The author(s) received no financial support for the research,
hypothesis that SI is more effective than JM&Str in the authorship, and/or publication of this article.
short term, pain was increased by more than 2-fold, and
functional outcomes did not change between 12 weeks and References
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