Documentos de Académico
Documentos de Profesional
Documentos de Cultura
Generalidades:
En la coagulación de la sangre, el factor VIII, también llamado factor anti-hemofílico A, es
una glucoproteína contenida en el plasma sanguíneo (aprox. 0.1 mg/dl) que actúa como uno de
los cofactores de la cascada de la coagulación. La deficiencia del factor VIII causa
una condición hereditaria, hemorrágica, conocida como hemofilia A.1 El factor VIII o factor
antihemofílico es un factor de la coagulación necesario para que se produzca una correcta
coagulación pasando por regulación y modulación de la cascada sanguínea tras una
hemorragia.
Localización en el ADN:
Lugar de expresión
a) mRNA
b) PROTEÍNA
LOCUS NP_000123 2351 aa linear PRI 03-
JUN-2018
DEFINITION coagulation factor VIII isoform a preproprotein [Homo sapiens].
ORIGIN
1 mqielstcff lcllrfcfsa trryylgave lswdymqsdl gelpvdarfp prvpksfpfn
61 tsvvykktlf veftdhlfni akprppwmgl lgptiqaevy dtvvitlknm ashpvslhav
121 gvsywkaseg aeyddqtsqr ekeddkvfpg gshtyvwqvl kengpmasdp lcltysylsh
181 vdlvkdlnsg ligallvcre gslakektqt lhkfillfav fdegkswhse tknslmqdrd
241 aasarawpkm htvngyvnrs lpgligchrk svywhvigmg ttpevhsifl eghtflvrnh
301 rqasleispi tfltaqtllm dlgqfllfch isshqhdgme ayvkvdscpe epqlrmknne
361 eaedydddlt dsemdvvrfd ddnspsfiqi rsvakkhpkt wvhyiaaeee dwdyaplvla
421 pddrsyksqy lnngpqrigr kykkvrfmay tdetfktrea iqhesgilgp llygevgdtl
481 liifknqasr pyniyphgit dvrplysrrl pkgvkhlkdf pilpgeifky kwtvtvedgp
541 tksdprcltr yyssfvnmer dlasgligpl licykesvdq rgnqimsdkr nvilfsvfde
601 nrswylteni qrflpnpagv qledpefqas nimhsingyv fdslqlsvcl hevaywyils
661 igaqtdflsv ffsgytfkhk mvyedtltlf pfsgetvfms menpglwilg chnsdfrnrg
721 mtallkvssc dkntgdyyed syedisayll sknnaieprs fsqnsrhpst rqkqfnatti
781 pendiektdp wfahrtpmpk iqnvsssdll mllrqsptph glslsdlqea kyetfsddps
841 pgaidsnnsl semthfrpql hhsgdmvftp esglqlrlne klgttaatel kkldfkvsst
901 snnlistips dnlaagtdnt sslgppsmpv hydsqldttl fgkkssplte sggplslsee
961 nndskllesg lmnsqesswg knvsstesgr lfkgkrahgp alltkdnalf kvsisllktn
1021 ktsnnsatnr kthidgpsll ienspsvwqn ilesdtefkk vtplihdrml mdknatalrl
1081 nhmsnkttss knmemvqqkk egpippdaqn pdmsffkmlf lpesarwiqr thgknslnsg
1141 qgpspkqlvs lgpeksvegq nflseknkvv vgkgeftkdv glkemvfpss rnlfltnldn
1201 lhennthnqe kkiqeeiekk etliqenvvl pqihtvtgtk nfmknlflls trqnvegsyd
1261 gayapvlqdf rslndstnrt kkhtahfskk geeenleglg nqtkqiveky acttrispnt
1321 sqqnfvtqrs kralkqfrlp leetelekri ivddtstqws knmkhltpst ltqidyneke
1381 kgaitqspls dcltrshsip qanrsplpia kvssfpsirp iyltrvlfqd nsshlpaasy
1441 rkkdsgvqes shflqgakkn nlslailtle mtgdqrevgs lgtsatnsvt ykkventvlp
1501 kpdlpktsgk vellpkvhiy qkdlfptets ngspghldlv egsllqgteg aikwneanrp
1561 gkvpflrvat essaktpskl ldplawdnhy gtqipkeewk sqekspekta fkkkdtilsl
1621 nacesnhaia ainegqnkpe ievtwakqgr terlcsqnpp vlkrhqreit rttlqsdqee
1681 idyddtisve mkkedfdiyd edenqsprsf qkktrhyfia averlwdygm sssphvlrnr
1741 aqsgsvpqfk kvvfqeftdg sftqplyrge lnehlgllgp yiraevedni mvtfrnqasr
1801 pysfysslis yeedqrqgae prknfvkpne tktyfwkvqh hmaptkdefd ckawayfsdv
1861 dlekdvhsgl igpllvchtn tlnpahgrqv tvqefalfft ifdetkswyf tenmerncra
1921 pcniqmedpt fkenyrfhai ngyimdtlpg lvmaqdqrir wyllsmgsne nihsihfsgh
1981 vftvrkkeey kmalynlypg vfetvemlps kagiwrvecl igehlhagms tlflvysnkc
2041 qtplgmasgh irdfqitasg qygqwapkla rlhysgsina wstkepfswi kvdllapmii
2101 hgiktqgarq kfsslyisqf iimysldgkk wqtyrgnstg tlmvffgnvd ssgikhnifn
2161 ppiiaryirl hpthysirst lrmelmgcdl nscsmplgme skaisdaqit assyftnmfa
2221 twspskarlh lqgrsnawrp qvnnpkewlq vdfqktmkvt gvttqgvksl ltsmyvkefl
2281 isssqdghqw tlffqngkvk vfqgnqdsft pvvnsldppl ltrylrihpq swvhqialrm
2341 evlgceaqdl y
c) ADN
a) Obtención y/o purificación del RNA mensajero (cDNA) del factor VIII de coagulación
mediante RTPCR.
OLIGO start len tm gc% any 3' seq
LEFT PRIMER 390 20 59.54 45.00 4.00 3.00
cacggatcaccttttcaaca
RIGHT PRIMER 8393 20 60.07 50.00 5.00 1.00
tggtgatatggcagactgga
SEQUENCE SIZE: 9048
1 gcttagtgctgagcacatccagtgggtaaagttccttaaaatgctctgcaaagaaattgg
61 gacttttcattaaatcagaaattttacttttttcccctcctgggagctaaagatatttta
121 gagaagaattaaccttttgcttctccagttgaacatttgtagcaataagtcatgcaaata
181 gagctctccacctgcttctttctgtgccttttgcgattctgctttagtgccaccagaaga
241 tactacctgggtgcagtggaactgtcatgggactatatgcaaagtgatctcggtgagctg
301 cctgtggacgcaagatttcctcctagagtgccaaaatcttttccattcaacacctcagtc
361 gtgtacaaaaagactctgtttgtagaattcacggatcaccttttcaacatcgctaagcca
>>>>>>>>>>>>>>>>>>>>
421 aggccaccctggatgggtctgctaggtcctaccatccaggctgaggtttatgatacagtg
481 gtcattacacttaagaacatggcttcccatcctgtcagtcttcatgctgttggtgtatcc
541 tactggaaagcttctgagggagctgaatatgatgatcagaccagtcaaagggagaaagaa
601 gatgataaagtcttccctggtggaagccatacatatgtctggcaggtcctgaaagagaat
661 ggtccaatggcctctgacccactgtgccttacctactcatatctttctcatgtggacctg
721 gtaaaagacttgaattcaggcctcattggagccctactagtatgtagagaagggagtctg
781 gccaaggaaaagacacagaccttgcacaaatttatactactttttgctgtatttgatgaa
841 gggaaaagttggcactcagaaacaaagaactccttgatgcaggatagggatgctgcatct
901 gctcgggcctggcctaaaatgcacacagtcaatggttatgtaaacaggtctctgccaggt
961 ctgattggatgccacaggaaatcagtctattggcatgtgattggaatgggcaccactcct
1021 gaagtgcactcaatattcctcgaaggtcacacatttcttgtgaggaaccatcgccaggcg
1081 tccttggaaatctcgccaataactttccttactgctcaaacactcttgatggaccttgga
1141 cagtttctactgttttgtcatatctcttcccaccaacatgatggcatggaagcttatgtc
1201 aaagtagacagctgtccagaggaaccccaactacgaatgaaaaataatgaagaagcggaa
1261 gactatgatgatgatcttactgattctgaaatggatgtggtcaggtttgatgatgacaac
1321 tctccttcctttatccaaattcgctcagttgccaagaagcatcctaaaacttgggtacat
1381 tacattgctgctgaagaggaggactgggactatgctcccttagtcctcgcccccgatgac
1441 agaagttataaaagtcaatatttgaacaatggccctcagcggattggtaggaagtacaaa
1501 aaagtccgatttatggcatacacagatgaaacctttaagactcgtgaagctattcagcat
1561 gaatcaggaatcttgggacctttactttatggggaagttggagacacactgttgattata
1621 tttaagaatcaagcaagcagaccatataacatctaccctcacggaatcactgatgtccgt
1681 cctttgtattcaaggagattaccaaaaggtgtaaaacatttgaaggattttccaattctg
1741 ccaggagaaatattcaaatataaatggacagtgactgtagaagatgggccaactaaatca
1801 gatcctcggtgcctgacccgctattactctagtttcgttaatatggagagagatctagct
1861 tcaggactcattggccctctcctcatctgctacaaagaatctgtagatcaaagaggaaac
1921 cagataatgtcagacaagaggaatgtcatcctgttttctgtatttgatgagaaccgaagc
1981 tggtacctcacagagaatatacaacgctttctccccaatccagctggagtgcagcttgag
2041 gatccagagttccaagcctccaacatcatgcacagcatcaatggctatgtttttgatagt
2101 ttgcagttgtcagtttgtttgcatgaggtggcatactggtacattctaagcattggagca
2161 cagactgacttcctttctgtcttcttctctggatataccttcaaacacaaaatggtctat
2221 gaagacacactcaccctattcccattctcaggagaaactgtcttcatgtcgatggaaaac
2281 ccaggtctatggattctggggtgccacaactcagactttcggaacagaggcatgaccgcc
2341 ttactgaaggtttctagttgtgacaagaacactggtgattattacgaggacagttatgaa
2401 gatatttcagcatacttgctgagtaaaaacaatgccattgaaccaagaagcttctcccag
2461 aattcaagacaccctagcactaggcaaaagcaatttaatgccaccacaattccagaaaat
2521 gacatagagaagactgacccttggtttgcacacagaacacctatgcctaaaatacaaaat
2581 gtctcctctagtgatttgttgatgctcttgcgacagagtcctactccacatgggctatcc
2641 ttatctgatctccaagaagccaaatatgagactttttctgatgatccatcacctggagca
2701 atagacagtaataacagcctgtctgaaatgacacacttcaggccacagctccatcacagt
2761 ggggacatggtatttacccctgagtcaggcctccaattaagattaaatgagaaactgggg
2821 acaactgcagcaacagagttgaagaaacttgatttcaaagtttctagtacatcaaataat
2881 ctgatttcaacaattccatcagacaatttggcagcaggtactgataatacaagttcctta
2941 ggacccccaagtatgccagttcattatgatagtcaattagataccactctatttggcaaa
3001 aagtcatctccccttactgagtctggtggacctctgagcttgagtgaagaaaataatgat
3061 tcaaagttgttagaatcaggtttaatgaatagccaagaaagttcatggggaaaaaatgta
3121 tcgtcaacagagagtggtaggttatttaaagggaaaagagctcatggacctgctttgttg
3181 actaaagataatgccttattcaaagttagcatctctttgttaaagacaaacaaaacttcc
3241 aataattcagcaactaatagaaagactcacattgatggcccatcattattaattgagaat
3301 agtccatcagtctggcaaaatatattagaaagtgacactgagtttaaaaaagtgacacct
3361 ttgattcatgacagaatgcttatggacaaaaatgctacagctttgaggctaaatcatatg
3421 tcaaataaaactacttcatcaaaaaacatggaaatggtccaacagaaaaaagagggcccc
3481 attccaccagatgcacaaaatccagatatgtcgttctttaagatgctattcttgccagaa
3541 tcagcaaggtggatacaaaggactcatggaaagaactctctgaactctgggcaaggcccc
3601 agtccaaagcaattagtatccttaggaccagaaaaatctgtggaaggtcagaatttcttg
3661 tctgagaaaaacaaagtggtagtaggaaagggtgaatttacaaaggacgtaggactcaaa
3721 gagatggtttttccaagcagcagaaacctatttcttactaacttggataatttacatgaa
3781 aataatacacacaatcaagaaaaaaaaattcaggaagaaatagaaaagaaggaaacatta
3841 atccaagagaatgtagttttgcctcagatacatacagtgactggcactaagaatttcatg
3901 aagaaccttttcttactgagcactaggcaaaatgtagaaggttcatatgacggggcatat
3961 gctccagtacttcaagattttaggtcattaaatgattcaacaaatagaacaaagaaacac
4021 acagctcatttctcaaaaaaaggggaggaagaaaacttggaaggcttgggaaatcaaacc
4081 aagcaaattgtagagaaatatgcatgcaccacaaggatatctcctaatacaagccagcag
4141 aattttgtcacgcaacgtagtaagagagctttgaaacaattcagactcccactagaagaa
4201 acagaacttgaaaaaaggataattgtggatgacacctcaacccagtggtccaaaaacatg
4261 aaacatttgaccccgagcaccctcacacagatagactacaatgagaaggagaaaggggcc
4321 attactcagtctcccttatcagattgccttacgaggagtcatagcatccctcaagcaaat
4381 agatctccattacccattgcaaaggtatcatcatttccatctattagacctatatatctg
4441 accagggtcctattccaagacaactcttctcatcttccagcagcatcttatagaaagaaa
4501 gattctggggtccaagaaagcagtcatttcttacaaggagccaaaaaaaataacctttct
4561 ttagccattctaaccttggagatgactggtgatcaaagagaggttggctccctggggaca
4621 agtgccacaaattcagtcacatacaagaaagttgagaacactgttctcccgaaaccagac
4681 ttgcccaaaacatctggcaaagttgaattgcttccaaaagttcacatttatcagaaggac
4741 ctattccctacggaaactagcaatgggtctcctggccatctggatctcgtggaagggagc
4801 cttcttcagggaacagagggagcgattaagtggaatgaagcaaacagacctggaaaagtt
4861 ccctttctgagagtagcaacagaaagctctgcaaagactccctccaagctattggatcct
4921 cttgcttgggataaccactatggtactcagataccaaaagaagagtggaaatcccaagag
4981 aagtcaccagaaaaaacagcttttaagaaaaaggataccattttgtccctgaacgcttgt
5041 gaaagcaatcatgcaatagcagcaataaatgagggacaaaataagcccgaaatagaagtc
5101 acctgggcaaagcaaggtaggactgaaaggctgtgctctcaaaacccaccagtcttgaaa
5161 cgccatcaacgggaaataactcgtactactcttcagtcagatcaagaggaaattgactat
5221 gatgataccatatcagttgaaatgaagaaggaagattttgacatttatgatgaggatgaa
5281 aatcagagcccccgcagctttcaaaagaaaacacgacactattttattgctgcagtggag
5341 aggctctgggattatgggatgagtagctccccacatgttctaagaaacagggctcagagt
5401 ggcagtgtccctcagttcaagaaagttgttttccaggaatttactgatggctcctttact
5461 cagcccttataccgtggagaactaaatgaacatttgggactcctggggccatatataaga
5521 gcagaagttgaagataatatcatggtaactttcagaaatcaggcctctcgtccctattcc
5581 ttctattctagccttatttcttatgaggaagatcagaggcaaggagcagaacctagaaaa
5641 aactttgtcaagcctaatgaaaccaaaacttacttttggaaagtgcaacatcatatggca
5701 cccactaaagatgagtttgactgcaaagcctgggcttatttctctgatgttgacctggaa
5761 aaagatgtgcactcaggcctgattggaccccttctggtctgccacactaacacactgaac
5821 cctgctcatgggagacaagtgacagtacaggaatttgctctgtttttcaccatctttgat
5881 gagaccaaaagctggtacttcactgaaaatatggaaagaaactgcagggctccctgcaat
5941 atccagatggaagatcccacttttaaagagaattatcgcttccatgcaatcaatggctac
6001 ataatggatacactacctggcttagtaatggctcaggatcaaaggattcgatggtatctg
6061 ctcagcatgggcagcaatgaaaacatccattctattcatttcagtggacatgtgttcact
6121 gtacgaaaaaaagaggagtataaaatggcactgtacaatctctatccaggtgtttttgag
6181 acagtggaaatgttaccatccaaagctggaatttggcgggtggaatgccttattggcgag
6241 catctacatgctgggatgagcacactttttctggtgtacagcaataagtgtcagactccc
6301 ctgggaatggcttctggacacattagagattttcagattacagcttcaggacaatatgga
6361 cagtgggccccaaagctggccagacttcattattccggatcaatcaatgcctggagcacc
6421 aaggagcccttttcttggatcaaggtggatctgttggcaccaatgattattcacggcatc
6481 aagacccagggtgcccgtcagaagttctccagcctctacatctctcagtttatcatcatg
6541 tatagtcttgatgggaagaagtggcagacttatcgaggaaattccactggaaccttaatg
6601 gtcttctttggcaatgtggattcatctgggataaaacacaatatttttaaccctccaatt
6661 attgctcgatacatccgtttgcacccaactcattatagcattcgcagcactcttcgcatg
6721 gagttgatgggctgtgatttaaatagttgcagcatgccattgggaatggagagtaaagca
6781 atatcagatgcacagattactgcttcatcctactttaccaatatgtttgccacctggtct
6841 ccttcaaaagctcgacttcacctccaagggaggagtaatgcctggagacctcaggtgaat
6901 aatccaaaagagtggctgcaagtggacttccagaagacaatgaaagtcacaggagtaact
6961 actcagggagtaaaatctctgcttaccagcatgtatgtgaaggagttcctcatctccagc
7021 agtcaagatggccatcagtggactctcttttttcagaatggcaaagtaaaggtttttcag
7081 ggaaatcaagactccttcacacctgtggtgaactctctagacccaccgttactgactcgc
7141 taccttcgaattcacccccagagttgggtgcaccagattgccctgaggatggaggttctg
7201 ggctgcgaggcacaggacctctactgagggtggccactgcagcacctgccactgccgtca
7261 cctctccctcctcagctccagggcagtgtccctccctggcttgccttctacctttgtgct
7321 aaatcctagcagacactgccttgaagcctcctgaattaactatcatcagtcctgcatttc
7381 tttggtggggggccaggagggtgcatccaatttaacttaactcttacctattttctgcag
7441 ctgctcccagattactccttccttccaatataactaggcaaaaagaagtgaggagaaacc
7501 tgcatgaaagcattcttccctgaaaagttaggcctctcagagtcaccacttcctctgttg
7561 tagaaaaactatgtgatgaaactttgaaaaagatatttatgatgttaacatttcaggtta
7621 agcctcatacgtttaaaataaaactctcagttgtttattatcctgatcaagcatggaaca
7681 aagcatgtttcaggatcagatcaatacaatcttggagtcaaaaggcaaatcatttggaca
7741 atctgcaaaatggagagaatacaataactactacagtaaagtctgtttctgcttccttac
7801 acatagatataattatgttatttagtcattatgaggggcacattcttatctccaaaacta
7861 gcattcttaaactgagaattatagatggggttcaagaatccctaagtcccctgaaattat
7921 ataaggcattctgtataaatgcaaatgtgcatttttctgacgagtgtccatagatataaa
7981 gccatttggtcttaattctgaccaataaaaaaataagtcaggaggatgcaattgttgaaa
8041 gctttgaaataaaataacaatgtcttcttgaaatttgtgatggccaagaaagaaaatgat
8101 gatgacattaggcttctaaaggacatacatttaatatttctgtggaaatatgaggaaaat
8161 ccatggttatctgagataggagatacaaactttgtaattctaataatgcactcagtttac
8221 tctctccctctactaatttcctgctgaaaataacacaacaaaaatgtaacaggggaaatt
8281 atataccgtgactgaaaactagagtcctacttacatagttgaaatatcaaggaggtcaga
8341 agaaaattggactggtgaaaacagaaaaaacactccagtctgccatatcaccacacaata
<<<<<<<<<<<<<<<<<<<<
8401 ggatcccccttcttgccctccacccccataagattgtgaagggtttactgctccttccat
8461 ctgcctgaccccttcactatgactacacagaatctcctgatagtaaagggggctggaggc
8521 aaggataagttatagagcagttggaggaagcatccaaagattgcaacccagggcaaatgg
8581 aaaacaggagatcctaatatgaaagaaaaatggatcccaatctgagaaaaggcaaaagaa
8641 tggctacttttttctatgctggagtattttctaataatcctgcttgacccttatctgacc
8701 tctttggaaactataacatagctgtcacagtatagtcacaatccacaaatgatgcaggtg
8761 caaatggtttatagccctgtgaagttcttaaagtttagaggctaacttacagaaatgaat
8821 aagttgttttgttttatagcccggtagaggagttaaccccaaaggtgatatggttttatt
8881 tcctgttatgtttaacttgataatcttattttggcattcttttcccattgactatataca
8941 tctctatttctcaaatgttcatggaactagctcttttattttcctgctggtttcttcagt
9001 aatgagttaaataaaacattgacacatacaaacaaaaaaaaaaaaaaa
5’-tccagtctgccatatcacca-3’
3’-accactataccgtctgacct-5’
Complementaria:
5’-tggtgatatggcagactgga-3’
b) Confirmación y/o análisis del cDNA factor VIII de coagulación mediante perfil de digestión
ezimatica (enzimas de restricción)
1 gcttagtgct gagcacatcc agtgggtaaa gttccttaaa atgctctgca aagaaattgg
61 gacttttcat taaatcagaa attttacttt tttcccctcc tgggagctaa agatatttta
121 gagaagaatt aaccttttgc ttctccagtt gaacatttgt agcaataagt catgcaaata
181 gagctctcca cctgcttctt tctgtgcctt ttgcgattct gctttagtgc caccagaaga
241 tactacctgg gtgcagtgga actgtcatgg gactatatgc aaagtgatct cggtgagctg
301 cctgtggacg caagatttcc tcctagagtg ccaaaatctt ttccattcaa cacctcagtc
361 gtgtacaaaa agactctgtt tgtagaattc acggatcacc ttttcaacat cgctaagcca
421 aggccaccct ggatgggtct gctaggtcct accatccagg ctgaggttta tgatacagtg
481 gtcattacac ttaagaacat ggcttcccat cctgtcagtc ttcatgctgt tggtgtatcc
541 tactggaaag cttctgaggg agctgaatat gatgatcaga ccagtcaaag ggagaaagaa
601 gatgataaag tcttccctgg tggaagccat acatatgtct ggcaggtcct gaaagagaat
661 ggtccaatgg cctctgaccc actgtgcctt acctactcat atctttctca tgtggacctg
721 gtaaaagact tgaattcagg cctcattgga gccctactag tatgtagaga agggagtctg
781 gccaaggaaa agacacagac cttgcacaaa tttatactac tttttgctgt atttgatgaa
841 gggaaaagtt ggcactcaga aacaaagaac tccttgatgc aggataggga tgctgcatct
901 gctcgggcct ggcctaaaat gcacacagtc aatggttatg taaacaggtc tctgccaggt
961 ctgattggat gccacaggaa atcagtctat tggcatgtga ttggaatggg caccactcct
1021 gaagtgcact caatattcct cgaaggtcac acatttcttg tgaggaacca tcgccaggcg
1081 tccttggaaa tctcgccaat aactttcctt actgctcaaa cactcttgat ggaccttgga
1141 cagtttctac tgttttgtca tatctcttcc caccaacatg atggcatgga agcttatgtc
1201 aaagtagaca gctgtccaga ggaaccccaa ctacgaatga aaaataatga agaagcggaa
1261 gactatgatg atgatcttac tgattctgaa atggatgtgg tcaggtttga tgatgacaac
1321 tctccttcct ttatccaaat tcgctcagtt gccaagaagc atcctaaaac ttgggtacat
1381 tacattgctg ctgaagagga ggactgggac tatgctccct tagtcctcgc ccccgatgac
1441 agaagttata aaagtcaata tttgaacaat ggccctcagc ggattggtag gaagtacaaa
1501 aaagtccgat ttatggcata cacagatgaa acctttaaga ctcgtgaagc tattcagcat
1561 gaatcaggaa tcttgggacc tttactttat ggggaagttg gagacacact gttgattata
1621 tttaagaatc aagcaagcag accatataac atctaccctc acggaatcac tgatgtccgt
1681 cctttgtatt caaggagatt accaaaaggt gtaaaacatt tgaaggattt tccaattctg
1741 ccaggagaaa tattcaaata taaatggaca gtgactgtag aagatgggcc aactaaatca
1801 gatcctcggt gcctgacccg ctattactct agtttcgtta atatggagag agatctagct
1861 tcaggactca ttggccctct cctcatctgc tacaaagaat ctgtagatca aagaggaaac
1921 cagataatgt cagacaagag gaatgtcatc ctgttttctg tatttgatga gaaccgaagc
1981 tggtacctca cagagaatat acaacgcttt ctccccaatc cagctggagt gcagcttgag
2041 gatccagagt tccaagcctc caacatcatg cacagcatca atggctatgt ttttgatagt
2101 ttgcagttgt cagtttgttt gcatgaggtg gcatactggt acattctaag cattggagca
2161 cagactgact tcctttctgt cttcttctct ggatatacct tcaaacacaa aatggtctat
2221 gaagacacac tcaccctatt cccattctca ggagaaactg tcttcatgtc gatggaaaac
2281 ccaggtctat ggattctggg gtgccacaac tcagactttc ggaacagagg catgaccgcc
2341 ttactgaagg tttctagttg tgacaagaac actggtgatt attacgagga cagttatgaa
2401 gatatttcag catacttgct gagtaaaaac aatgccattg aaccaagaag cttctcccag
2461 aattcaagac accctagcac taggcaaaag caatttaatg ccaccacaat tccagaaaat
2521 gacatagaga agactgaccc ttggtttgca cacagaacac ctatgcctaa aatacaaaat
2581 gtctcctcta gtgatttgtt gatgctcttg cgacagagtc ctactccaca tgggctatcc
2641 ttatctgatc tccaagaagc caaatatgag actttttctg atgatccatc acctggagca
2701 atagacagta ataacagcct gtctgaaatg acacacttca ggccacagct ccatcacagt
2761 ggggacatgg tatttacccc tgagtcaggc ctccaattaa gattaaatga gaaactgggg
2821 acaactgcag caacagagtt gaagaaactt gatttcaaag tttctagtac atcaaataat
2881 ctgatttcaa caattccatc agacaatttg gcagcaggta ctgataatac aagttcctta
2941 ggacccccaa gtatgccagt tcattatgat agtcaattag ataccactct atttggcaaa
3001 aagtcatctc cccttactga gtctggtgga cctctgagct tgagtgaaga aaataatgat
3061 tcaaagttgt tagaatcagg tttaatgaat agccaagaaa gttcatgggg aaaaaatgta
3121 tcgtcaacag agagtggtag gttatttaaa gggaaaagag ctcatggacc tgctttgttg
3181 actaaagata atgccttatt caaagttagc atctctttgt taaagacaaa caaaacttcc
3241 aataattcag caactaatag aaagactcac attgatggcc catcattatt aattgagaat
3301 agtccatcag tctggcaaaa tatattagaa agtgacactg agtttaaaaa agtgacacct
3361 ttgattcatg acagaatgct tatggacaaa aatgctacag ctttgaggct aaatcatatg
3421 tcaaataaaa ctacttcatc aaaaaacatg gaaatggtcc aacagaaaaa agagggcccc
3481 attccaccag atgcacaaaa tccagatatg tcgttcttta agatgctatt cttgccagaa
3541 tcagcaaggt ggatacaaag gactcatgga aagaactctc tgaactctgg gcaaggcccc
3601 agtccaaagc aattagtatc cttaggacca gaaaaatctg tggaaggtca gaatttcttg
3661 tctgagaaaa acaaagtggt agtaggaaag ggtgaattta caaaggacgt aggactcaaa
3721 gagatggttt ttccaagcag cagaaaccta tttcttacta acttggataa tttacatgaa
3781 aataatacac acaatcaaga aaaaaaaatt caggaagaaa tagaaaagaa ggaaacatta
3841 atccaagaga atgtagtttt gcctcagata catacagtga ctggcactaa gaatttcatg
3901 aagaaccttt tcttactgag cactaggcaa aatgtagaag gttcatatga cggggcatat
3961 gctccagtac ttcaagattt taggtcatta aatgattcaa caaatagaac aaagaaacac
4021 acagctcatt tctcaaaaaa aggggaggaa gaaaacttgg aaggcttggg aaatcaaacc
4081 aagcaaattg tagagaaata tgcatgcacc acaaggatat ctcctaatac aagccagcag
4141 aattttgtca cgcaacgtag taagagagct ttgaaacaat tcagactccc actagaagaa
4201 acagaacttg aaaaaaggat aattgtggat gacacctcaa cccagtggtc caaaaacatg
4261 aaacatttga ccccgagcac cctcacacag atagactaca atgagaagga gaaaggggcc
4321 attactcagt ctcccttatc agattgcctt acgaggagtc atagcatccc tcaagcaaat
4381 agatctccat tacccattgc aaaggtatca tcatttccat ctattagacc tatatatctg
4441 accagggtcc tattccaaga caactcttct catcttccag cagcatctta tagaaagaaa
4501 gattctgggg tccaagaaag cagtcatttc ttacaaggag ccaaaaaaaa taacctttct
4561 ttagccattc taaccttgga gatgactggt gatcaaagag aggttggctc cctggggaca
4621 agtgccacaa attcagtcac atacaagaaa gttgagaaca ctgttctccc gaaaccagac
4681 ttgcccaaaa catctggcaa agttgaattg cttccaaaag ttcacattta tcagaaggac
4741 ctattcccta cggaaactag caatgggtct cctggccatc tggatctcgt ggaagggagc
4801 cttcttcagg gaacagaggg agcgattaag tggaatgaag caaacagacc tggaaaagtt
4861 ccctttctga gagtagcaac agaaagctct gcaaagactc cctccaagct attggatcct
4921 cttgcttggg ataaccacta tggtactcag ataccaaaag aagagtggaa atcccaagag
4981 aagtcaccag aaaaaacagc ttttaagaaa aaggatacca ttttgtccct gaacgcttgt
5041 gaaagcaatc atgcaatagc agcaataaat gagggacaaa ataagcccga aatagaagtc
5101 acctgggcaa agcaaggtag gactgaaagg ctgtgctctc aaaacccacc agtcttgaaa
5161 cgccatcaac gggaaataac tcgtactact cttcagtcag atcaagagga aattgactat
5221 gatgatacca tatcagttga aatgaagaag gaagattttg acatttatga tgaggatgaa
5281 aatcagagcc cccgcagctt tcaaaagaaa acacgacact attttattgc tgcagtggag
5341 aggctctggg attatgggat gagtagctcc ccacatgttc taagaaacag ggctcagagt
5401 ggcagtgtcc ctcagttcaa gaaagttgtt ttccaggaat ttactgatgg ctcctttact
5461 cagcccttat accgtggaga actaaatgaa catttgggac tcctggggcc atatataaga
5521 gcagaagttg aagataatat catggtaact ttcagaaatc aggcctctcg tccctattcc
5581 ttctattcta gccttatttc ttatgaggaa gatcagaggc aaggagcaga acctagaaaa
5641 aactttgtca agcctaatga aaccaaaact tacttttgga aagtgcaaca tcatatggca
5701 cccactaaag atgagtttga ctgcaaagcc tgggcttatt tctctgatgt tgacctggaa
5761 aaagatgtgc actcaggcct gattggaccc cttctggtct gccacactaa cacactgaac
5821 cctgctcatg ggagacaagt gacagtacag gaatttgctc tgtttttcac catctttgat
5881 gagaccaaaa gctggtactt cactgaaaat atggaaagaa actgcagggc tccctgcaat
5941 atccagatgg aagatcccac ttttaaagag aattatcgct tccatgcaat caatggctac
6001 ataatggata cactacctgg cttagtaatg gctcaggatc aaaggattcg atggtatctg
6061 ctcagcatgg gcagcaatga aaacatccat tctattcatt tcagtggaca tgtgttcact
6121 gtacgaaaaa aagaggagta taaaatggca ctgtacaatc tctatccagg tgtttttgag
6181 acagtggaaa tgttaccatc caaagctgga atttggcggg tggaatgcct tattggcgag
6241 catctacatg ctgggatgag cacacttttt ctggtgtaca gcaataagtg tcagactccc
6301 ctgggaatgg cttctggaca cattagagat tttcagatta cagcttcagg acaatatgga
6361 cagtgggccc caaagctggc cagacttcat tattccggat caatcaatgc ctggagcacc
6421 aaggagccct tttcttggat caaggtggat ctgttggcac caatgattat tcacggcatc
6481 aagacccagg gtgcccgtca gaagttctcc agcctctaca tctctcagtt tatcatcatg
6541 tatagtcttg atgggaagaa gtggcagact tatcgaggaa attccactgg aaccttaatg
6601 gtcttctttg gcaatgtgga ttcatctggg ataaaacaca atatttttaa ccctccaatt
6661 attgctcgat acatccgttt gcacccaact cattatagca ttcgcagcac tcttcgcatg
6721 gagttgatgg gctgtgattt aaatagttgc agcatgccat tgggaatgga gagtaaagca
6781 atatcagatg cacagattac tgcttcatcc tactttacca atatgtttgc cacctggtct
6841 ccttcaaaag ctcgacttca cctccaaggg aggagtaatg cctggagacc tcaggtgaat
6901 aatccaaaag agtggctgca agtggacttc cagaagacaa tgaaagtcac aggagtaact
6961 actcagggag taaaatctct gcttaccagc atgtatgtga aggagttcct catctccagc
7021 agtcaagatg gccatcagtg gactctcttt tttcagaatg gcaaagtaaa ggtttttcag
7081 ggaaatcaag actccttcac acctgtggtg aactctctag acccaccgtt actgactcgc
7141 taccttcgaa ttcaccccca gagttgggtg caccagattg ccctgaggat ggaggttctg
7201 ggctgcgagg cacaggacct ctactgaggg tggccactgc agcacctgcc actgccgtca
7261 cctctccctc ctcagctcca gggcagtgtc cctccctggc ttgccttcta cctttgtgct
7321 aaatcctagc agacactgcc ttgaagcctc ctgaattaac tatcatcagt cctgcatttc
7381 tttggtgggg ggccaggagg gtgcatccaa tttaacttaa ctcttaccta ttttctgcag
7441 ctgctcccag attactcctt ccttccaata taactaggca aaaagaagtg aggagaaacc
7501 tgcatgaaag cattcttccc tgaaaagtta ggcctctcag agtcaccact tcctctgttg
7561 tagaaaaact atgtgatgaa actttgaaaa agatatttat gatgttaaca tttcaggtta
7621 agcctcatac gtttaaaata aaactctcag ttgtttatta tcctgatcaa gcatggaaca
7681 aagcatgttt caggatcaga tcaatacaat cttggagtca aaaggcaaat catttggaca
7741 atctgcaaaa tggagagaat acaataacta ctacagtaaa gtctgtttct gcttccttac
7801 acatagatat aattatgtta tttagtcatt atgaggggca cattcttatc tccaaaacta
7861 gcattcttaa actgagaatt atagatgggg ttcaagaatc cctaagtccc ctgaaattat
7921 ataaggcatt ctgtataaat gcaaatgtgc atttttctga cgagtgtcca tagatataaa
7981 gccatttggt cttaattctg accaataaaa aaataagtca ggaggatgca attgttgaaa
8041 gctttgaaat aaaataacaa tgtcttcttg aaatttgtga tggccaagaa agaaaatgat
8101 gatgacatta ggcttctaaa ggacatacat ttaatatttc tgtggaaata tgaggaaaat
8161 ccatggttat ctgagatagg agatacaaac tttgtaattc taataatgca ctcagtttac
8221 tctctccctc tactaatttc ctgctgaaaa taacacaaca aaaatgtaac aggggaaatt
8281 atataccgtg actgaaaact agagtcctac ttacatagtt gaaatatcaa ggaggtcaga
8341 agaaaattgg actggtgaaa acagaaaaaa cactccagtc tgccatatca ccacacaata
8401 ggatccccct tcttgccctc cacccccata agattgtgaa gggtttactg ctccttccat
8461 ctgcctgacc ccttcactat gactacacag aatctcctga tagtaaaggg ggctggaggc
8521 aaggataagt tatagagcag ttggaggaag catccaaaga ttgcaaccca gggcaaatgg
8581 aaaacaggag atcctaatat gaaagaaaaa tggatcccaa tctgagaaaa ggcaaaagaa
8641 tggctacttt tttctatgct ggagtatttt ctaataatcc tgcttgaccc ttatctgacc
8701 tctttggaaa ctataacata gctgtcacag tatagtcaca atccacaaat gatgcaggtg
8761 caaatggttt atagccctgt gaagttctta aagtttagag gctaacttac agaaatgaat
8821 aagttgtttt gttttatagc ccggtagagg agttaacccc aaaggtgata tggttttatt
8881 tcctgttatg tttaacttga taatcttatt ttggcattct tttcccattg actatataca
8941 tctctatttc tcaaatgttc atggaactag ctcttttatt ttcctgctgg tttcttcagt
9001 aatgagttaa ataaaacatt gacacataca aacaaaaaaa aaaaaaaa
LOCUS NM_000128 3278 bp mRNA linear PRI 08-
JUL-2018
DEFINITION Homo sapiens coagulation factor XI (F11), transcript variant
1,