PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 22- JUNIO-18

ACIDO ´POLIGLICOLICO CALIBRE: 1 LOTE: S180181

PRUEBA COMPARATIVA A 50°C

PROVEEDOR DE MATERIA PRIMA GUNZE

RESISTENCI
A DEL
NUDO (kgf)

14 DIAS
INICIAL 3 DIAS- 53°C 4 DIAS 53°C 37°C
1 8.043 6.263 5.286 6.851
2 8.934 7.237 5.855 5.855
3 8.435 6.663 5.425 6.660
4 8.344 6.829 4.768 6.174
5 8.113 6.856 5.240 6.803
6 8.872 7.323 5.227 6.569
7 8.478 6.773 5.761 6.735
8 8.778 6.966 5.442 6.717
9 8.816 6.722 5.685 6.832
10 8.843 6.878 5.444 7.093
11 8.636 6.738 5.381 6.937
12 8.392 6.980 5.423 6.333
PROM 8.557 6.852 5.411 6.630
DESV-STD 0.302 0.273 0.284 0.350
MAX 8.934 7.323 5.855 7.093
MIN 8.043 6.263 4.768 5.855
% RETENCION 100.0% 80.1% 63.2% 77.5%
PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 06- JUNIO-18
ACIDO POLOGLICOLICO CALIBRE: 1 LOTE: S180174
PRUEBA COMPARATIVA A 53°C

PROVEEDOR DE MATERIA PRIMA GUNZE

RESISTENCI
A DEL
NUDO (kgf)

14 DIAS
INICIAL 3 DIAS- 53°C 4 DIAS 53°C 37°C
1 8.569 4.419 2.561 5.101
2 8.102 5.302 2.674 4.467
3 8.024 4.966 3.259 4.458
4 7.777 4.926 3.133 5.831
5 8.483 4.534 2.571 5.248
6 7.648 5.189 3.117 4.711
7 7.930 4.258 2.781 4.483
8 8.215 4.362 3.229 4.991
9 7.643 4.169 2.964 4.531
10 8.153 4.413 2.805 5.842
11 7.589 4.693 3.034 4.489
12 7.793 4.733 2.886 6.059
PROM 7.994 4.664 2.918 5.018
DESV-STD 0.324 0.368 0.244 0.603
MAX 8.569 5.302 3.259 6.059
MIN 7.589 4.169 2.561 4.458
% RETENCION 100.0% 58.3% 36.5% 62.8%
 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 06- JUNIO-18
ACIDO PLOGLICOLICO CALIBRE: 1 LOTE: S180158
PRUEBA COMPARATIVA A 53°C

PROVEEDOR DE MATERIA PRIMA GUNZE

RESISTENCI
A DEL
NUDO (kgf)

3 DIAS 14 DIAS
INICIAL 4 DIAS 53°C
53°C 37°C
1 8.236 4.660 3.947 4.910 y x
2 7.023 4.985 1.750 6.537 100 0
3 8.043 5.377 3.297 4.091 61.9 3
4 7.930 5.385 3.146 5.847 42.3 4
5 7.348 4.733 3.627 6.647 71.7 14
6 7.568 4.344 3.898 5.976
7 8.102 5.330 3.313 3.839
8 7.433 4.518 1.887 6.459
9 7.946 4.290 3.869 6.413
10 8.166 5.042 3.332 3.913
11 7.766 4.891 3.936 6.105
12 8.341 4.612 3.751 6.607
PROM 7.825 4.847 3.313 5.612
DESV-STD 0.404 0.386 0.753 1.110
MAX 8.341 5.385 3.947 6.647
MIN 7.023 4.290 1.750 3.839
% RETENCION 100.0% 61.9% 42.3% 71.7%

Degradacion PGA
120

100 100

80
61.9 71.7
60

40 42.3

20

0
0 2 4 6 8 10 12 14 16
 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 15- 05-18
ACIDO POLIGLICOLICO CALIBRE: 1 LOTE: S180136
PRUEBA COMPARATIVA A 53°C PARA DETERMINAR LOS DIAS EQUIVALENTES ALA TEMPERATURA DE 37°C A 14 DIAS

PROVEEDOR
RESISTENCIA DE MATERIA PRIMA GUNZE
DEL NUDO
(kgf) 5-May-18 6-May-18 7-May-18 15-May-18
INICIAL 3 DIAS- 53°C 4 DIAS 53°C 5 DIAS 53°C 14 DIAS 37°C
1 8.137 3.232 1.664 1.329 4.658
2 8.338 4.403 1.447 1.788 4.231
3 7.560 4.368 2.271 1.383 3.918
4 8.182 3.184 1.581 0.679 4.191
5 7.315 4.454 2.075 0.743 3.401
6 7.466 4.384 1.987 1.076 4.395
7 6.660 4.242 2.250 0.773 3.685
8 7.415 3.863 2.244 1.050 4.268
9 7.648 3.404 2.325 1.694 3.992
10 7.917 3.965 1.863 0.794 3.656
11 7.911 4.357 2.489 2.150 3.962
12 7.374 4.370 2.607 0.963 4.378
PROM 7.660 4.019 2.067 1.202 4.061
DESV-STD 0.467 0.486 0.366 0.473 0.361
MAX 8.338 4.454 2.607 2.150 4.658
MIN 6.660 3.184 1.447 0.679 3.401
% RETENCION 100.0% 52.5% 27.0% 15.7% 53.0%

120.0%

100.0%
100.0%
80.0%

60.0%

40.0% 52.5% 53.0%

27.0%
15.7%
20.0%

0.0%
INICIAL 3 DIAS- 53°C 4 DIAS 53°C 5 DIAS 53°C 14 DIAS 37°C

REALIZO:
JULIO VALDEZ
 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 30- mayo-18
POLIDIOXANONA CALIBRE: 1 LOTE: S180149
PRUEBA COMPARATIVA A 53°C

PROVEEDOR DE MATERIA PRIMA GUNZE

RESISTENCIA
DEL NUDO (kgf)

30 DIAS
INICIAL 7 DIAS- 53°C 8 DIAS 53°C 37°C
1 7.186 4.545 4.762 4.701 y x
2 7.627 5.509 4.454 4.620 100 0
3 7.095 4.972 4.067 5.670 70.5 7
4 7.095 4.934 4.153 4.365 62.5 8
5 7.004 5.350 4.604 3.957
6 7.348 4.035 4.566 5.243
7 7.444 5.015 4.515 4.542
8 8.389 5.162 4.451 5.662
9 7.009 5.479 4.569 5.103
10 6.797 5.119 5.259 4.639
11 7.240 5.785 4.572 4.523
12 7.066 5.632 4.623 4.301
PROM 7.275 5.128 4.550 4.777
DESV-STD 0.414 0.487 0.297 0.534
MAX 8.389 5.785 5.259 5.670
MIN 6.797 4.035 4.067 3.957
% RETENCION 100.0% 70.5% 62.5% 65.7%

% DE DEGRADACION
120
100
100
f(x) = - 4.5131578947x + 100.2324561404
80 70.5
62.5
60

40

20

0
0 1 2 3 4 5 6 7 8 9

REALIZO: JULIO VALDEZ

 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 30- mayo-18
POLIDIOXANONA CALIBRE: 1 LOTE: S180148
PRUEBA COMPARATIVA A 53°C

PROVEEDOR DE MATERIA PRIMA GUNZE

RESISTENCIA
DEL NUDO (kgf)
7-May-18 8-May-18 30-May-18
30 DIAS
INICIAL 7 DIAS- 53°C 8 DIAS 53°C 37°C
1 8.156 5.391 5.125 4.714 y x
2 7.106 5.095 4.776 4.566 100 0
3 7.025 5.310 4.510 4.558 70.7 7
4 7.348 5.297 4.725 3.675 65.8 8
5 6.706 5.044 5.157 3.866
6 7.640 5.017 4.977 5.133
7 7.060 5.090 4.059 5.629
8 7.600 5.635 4.425 4.894
9 7.356 5.361 4.480 4.438
10 6.891 4.894 5.184 4.110
11 7.552 5.058 5.415 4.690
12 7.047 4.701 4.762 4.582
PROM 7.291 5.158 4.800 4.571
DESV-STD 0.400 0.251 0.390 0.531
MAX 8.156 5.635 5.415 5.629
MIN 6.706 4.701 4.059 3.675
% RETENCION 100.0% 70.7% 65.8% 62.7%

% de Degradacion
120

100 100
f(x) = - 4.2421052632x + 100.0438596491
80 70.7
65.8
60

40

20

0
0 1 2 3 4 5 6 7 8 9

REALIZO: JULIO VALDEZ

 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 10- marzo-18
POLIDIOXANONA CALIBRE: 1 LOTE: S180074
PRUEBA COMPARATIVA A 14 DIAS , A UNA TEMPERATURA DE 53°C

10-Apr-18 11-Apr-18 12-Apr-18 13-Apr-18 14-Apr-18 15-Apr-18 16-Apr-18 17-Apr-18 18-Apr-18 10-Apr-18 10-Apr-18
INICIAL 4 DIAS 5 DIAS 6 DIAS 7 DIAS 8 DIAS 9 DIAS 10 DIAS 11 DIAS 12 DIAS 13 DIAS 14 DIAS
1 7.369 6.827 7.793 5.930 6.824 4.999 5.463 4.325 4.236 2.864
2 6.988 6.403 6.059 5.917 5.544 5.291 4.895 4.958 4.016 3.753
3 7.068 6.687 5.925 6.540 6.564 4.950 4.963 4.811 3.576 2.438
4 7.015 7.299 5.576 5.766 5.702 4.338 4.212 5.466 3.458 2.736
5 6.931 6.633 6.373 4.824 4.762 4.327 4.829 5.197 3.181 3.181
6 7.122 5.866 6.612 5.758 6.293 4.883 4.719 4.897 3.756 2.896
7 7.050 6.942 5.613 5.836 6.140 5.058 3.876 5.015 4.123 2.376
8 6.765 6.400 5.369 5.372 6.491 4.958 4.432 4.698 3.334 3.051
9 7.020 6.180 6.021 6.008 5.213 4.875 4.217 4.625 3.616 3.409
10 6.588 6.094 6.140 5.270 5.611 5.208 4.364 4.475 3.332 2.787
120.0%
11 6.846 6.973 7.168 6.225 5.799 5.500 4.174 4.982 4.062 3.439
12 6.733 7.184 6.472 5.587 5.909 5.082 4.435 4.096 3.353 4.274 100.0%

PROM 6.958 6.624 6.260 5.753 5.904 4.956 4.548 4.795 3.670 3.100 #DIV/0! #DIV/0! 80.0%
DESV-STD 0.205 0.446 0.692 0.451 0.594 0.342 0.438 0.379 0.361 0.549 #DIV/0! #DIV/0!
60.0%
MAX 7.369 7.299 7.793 6.540 6.824 5.500 5.463 5.466 4.236 4.274 0.000 0.000
MIN 6.588 5.866 5.369 4.824 4.762 4.327 3.876 4.096 3.181 2.376 0.000 0.000 40.0%
% RETENCION 100.0% 95.2% 90.0% 82.7% 84.9% 71.2% 65.4% 68.9% 52.7% 44.6% #DIV/0! #DIV/0! 20.0%

0.0%
0.0% 200.0% 40

REALIZO:
JULIO VALDEZ
 120.0%

100.0%
f(x) = - 0.0428061561x + 1.033835559
100.0%
95.2%
R² = 0.8911439942
80.0% 90.0%
82.7% 84.9%

60.0%

40.0%

20.0%

0.0%
120.0% 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 5.5

100.0%

80.0%

60.0%

40.0%

20.0%

0.0%
0.0% 200.0% 400.0% 600.0% 800.0% 1000.0% 1200.0%
 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 10- marzo-18
POLIDIOXANONA CALIBRE: 1 LOTE: S180074
PRUEBA COMPARATIVA A 14 DIAS , A UNA TEMPERATURA DE 53°C

10-Apr-18 11-Apr-18 12-Apr-18 13-Apr-18 14-Apr-18 10-Apr-18 10-Apr-18 10-Apr-18 10-Apr-18 10-Apr-18 10-Apr-18
INICIAL 4 DIAS 5 DIAS 6 DIAS 7 DIAS 8 DIAS 9 DIAS 10 DIAS 11 DIAS 12 DIAS 13 DIAS 14 DIAS
1 7.369 6.827 7.793 5.930 6.824 120.0%
2 6.988 6.403 6.059 5.917 5.544
100.0%
3 7.068 6.687 5.925 6.540 6.564 f(x) =
100.0%
R² =
4 7.015 7.299 5.576 5.766 5.702 80.0%
5 6.931 6.633 6.373 4.824 4.762
6 7.122 5.866 6.612 5.758 6.293 60.0%

7 7.050 6.942 5.613 5.836 6.140

40.0%
8 6.765 6.400 5.369 5.372 6.491
9 7.020 6.180 6.021 6.008 5.213 20.0%
10 6.588 6.094 6.140 5.270 5.611
0.0%
11 6.846 6.973 7.168 6.225 5.799 0.5 1
12 6.733 7.184 6.472 5.587 5.909
PROM 6.958 6.624 6.260 5.753 5.904 #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0!
DESV-STD 0.205 0.446 0.692 0.451 0.594 #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0!
MAX 7.369 7.299 7.793 6.540 6.824 0.000 0.000 0.000 0.000 0.000 0.000 0.000
MIN 6.588 5.866 5.369 4.824 4.762 0.000 0.000 0.000 0.000 0.000 0.000 0.000
% RETENCION 100.0% 95.2% 90.0% 82.7% 84.9% #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0! #DIV/0!

REALIZO:
JULIO VALDEZ
120.0%

100.0%
f(x) = - 0.0428061561x + 1.033835559
100.0%
95.2%
R² = 0.8911439942
80.0% 90.0%
82.7% 84.9%

60.0%

40.0%

20.0%

0.0%
0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 5.5
 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 18- ABRIL-18
POLIDIOXANONA CALIBRE: 1 LOTE: S180074
PRUEBA COMPARATIVA A 14 DIAS , A UNA TEMPERATURA DE 53°C

10-Apr-18 11-Apr-18 12-Apr-18 13-Apr-18 14-Apr-18 15-Apr-18 16-Apr-18 17-Apr-18 18-Apr-18 18-Apr-18 20-Apr-18
INICIAL 4 DIAS 5 DIAS 6 DIAS 7 DIAS 8 DIAS 9 DIAS 10 DIAS 11 DIAS 12 DIAS 30 DIAS 14 DIAS
1 7.369 6.827 7.793 5.930 6.824 4.999 5.463 4.325 4.236 2.864 5.305
2 6.988 6.403 6.059 5.917 5.544 5.291 4.895 4.958 4.016 3.753 5.680
3 7.068 6.687 5.925 6.540 6.564 4.950 4.963 4.811 3.576 2.438 6.013
4 7.015 7.299 5.576 5.766 5.702 4.338 4.212 5.466 3.458 2.736 4.392
5 6.931 6.633 6.373 4.824 4.762 4.327 4.829 5.197 3.181 3.181 5.474
6 7.122 5.866 6.612 5.758 6.293 4.883 4.719 4.897 3.756 2.896 5.715
7 7.050 6.942 5.613 5.836 6.140 5.058 3.876 5.015 4.123 2.376 4.172
8 6.765 6.400 5.369 5.372 6.491 4.958 4.432 4.698 3.334 3.051 6.129
9 7.020 6.180 6.021 6.008 5.213 4.875 4.217 4.625 3.616 3.409 6.067
10 6.588 6.094 6.140 5.270 5.611 5.208 4.364 4.475 3.332 2.787 5.152
11 6.846 6.973 7.168 6.225 5.799 5.500 4.174 4.982 4.062 3.439 5.110
12 6.733 7.184 6.472 5.587 5.909 5.082 4.435 4.096 3.353 4.274 5.076
PROM 6.958 6.624 6.260 5.753 5.904 4.956 4.548 4.795 3.670 3.100 5.357 #DIV/0!
DESV-STD 0.205 0.446 0.692 0.451 0.594 0.342 0.438 0.379 0.361 0.549 0.625 #DIV/0!
MAX 7.369 7.299 7.793 6.540 6.824 5.500 5.463 5.466 4.236 4.274 6.129 0.000
MIN 6.588 5.866 5.369 4.824 4.762 4.327 3.876 4.096 3.181 2.376 4.172 0.000
% RETENCION 100.0% 95.2% 90.0% 82.7% 84.9% 71.2% 65.4% 68.9% 52.7% 44.6% 77.0% #DIV/0!

REALIZO:
JULIO VALDEZ
 PORCENTAJE DE DEGRADACION DE POLIDIOXANONA CAL. 1 53°C

120.0%

100.0%
f(x) = - 0.0586033277x + 1.0778473761
100.0%
R² =95.2%
0.9520413465
80.0% 90.0%
82.7% 84.9%
71.2% 68.9%
60.0% 65.4%
52.7%
40.0% 44.6%

20.0%

0.0%
0 1 2 3 4 5 6 7 8 9 10 11

REALIZO:
JULIO VALDEZ
 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 02- MAR-18
POLIDIOXANONA CALIBRE: 1-0 LOTE: 0400V0030

PRUEBA COMPARATIVA A 14 DIAS , A UNA TEMPERATURA DE 43°C

PROVEEDOR DE MATERIA PRIMA GUNZE

RESISTENCIA DEL NUDO

(kgf)
22-Feb-18 28-Feb-18 1-Mar-18 2-Mar-18
INICIAL DIA 7 DIA 8 DIA 9

1 5.506 5.420 5.652 5.004

2 5.490 5.106 5.203 5.157 COMPARCION DE DEGRADACIONES
3 6.140 6.443 5.552 4.505 102.0%
4 5.720 5.385 5.146 4.977 100.0% f(x) = - 0.0434255886x + 1.0502153573
5 6.177 6.040 4.515 5.050 98.0% R² = 0.9457693287
6 5.262 4.966 5.047 5.111 96.0%
7 5.697 5.471 4.827 4.577 94.0%
8 5.855 5.476 4.813 4.770
92.0%
9 6.133 5.012 5.331 4.196
90.0%
10 5.993 5.680 5.044 5.074
88.0%
11 4.125 5.627 4.926 4.758
86.0%
12 5.364 5.517 5.074 5.028
84.0%
PROM 5.622 5.512 5.094 4.851
82.0%
DESV-STD 0.565 0.419 0.318 0.295 INICIAL DIA 7 DIA 8 DIA 9
MAX 6.177 6.443 5.652 5.157
MIN 4.125 4.966 4.515 4.196
% RETENCION 100.0% 98.0% 90.6% 88.0%
REALIZO:
JULIO VALDEZ
DIA 9
 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 01- MAR-18
ACIDO POLIGLICOLICO CALIBRE: 1 LOTE: S180052

PRUEBA COMPARATIVA A DETERMINADOS DIAS , DIFERENTES TEMPERATURAS

PROVEEDOR DE MATERIA PRIMA GUNZE

RESISTENCIA DEL NUDO

(kgf)
21-Feb-18 28-Feb-18

INICIAL 7 DIAS- 43°C 14 DIAS- 37°C

1 8.561 6.207 4.040 COMPARCION DE DEGRADACIONES

2 8.926 6.542 4.341 10.000
3 8.301 6.048 3.650
9.000
4 8.706 6.768 4.051
8.000
5 8.819 6.567 4.762
7.000
6 8.411 5.914 4.811
6.000
7 8.491 6.631 4.703
5.000
8 8.333 6.258 3.889
4.000
9 8.525 6.429 4.612
3.000
10 9.033 5.573 4.131
2.000
11 8.483 5.611 3.596
1.000
12 8.633 5.656 5.200
0.000
PROM 8.602 6.175 4.316 INICIAL 7 DIAS- 43°C 14 DIAS- 37
DESV-STD 0.230 0.414 0.503
MAX 9.033 6.768 5.200
MIN 8.301 5.573 3.596
% RETENCION 100.0% 71.8% 50.2%

REALIZO:
JULIO VALDEZ
IONES

14 DIAS- 37°C
 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 28- FEB-18
ACIDO POLIGLICOLICO CALIBRE: 1 LOTE: S180050

PRUEBA COMPARATIVA A DETERMINADOS DIAS , DIFERENTES TEMPERATURAS

PROVEEDOR DE MATERIA PRIMA GUNZE

RESISTENCIA DEL NUDO

(kgf)
21-Feb-18 28-Feb-18

INICIAL 7 DIAS- 43°C 14 DIAS- 37°C

1 8.561 6.207 4.040

2 8.926 6.542 4.341 COMPARCION DE DEGRADACIONES
3 8.301 6.048 3.650 10.000
4 8.706 6.768 4.051 9.000
5 8.819 6.567 4.762 8.000
6 8.411 5.914 4.811 7.000
7 8.491 6.631 4.703 6.000
8 8.333 6.258 3.889 5.000
9 8.525 6.429 4.612
4.000
10 9.033 5.573 4.131
3.000
11 8.483 5.611 3.596
2.000
12 8.633 5.656 5.200
1.000
PROM 8.602 6.175 4.316
0.000
DESV-STD 0.230 0.414 0.503 INICIAL 7 DIAS- 43°C 14 DIAS- 37°C
MAX 9.033 6.768 5.200
MIN 8.301 5.573 3.596
% RETENCION 100.0% 71.8% 50.2%

REALIZO:
JULIO VALDEZ
14 DIAS- 37°C
 PRUEBA DEGRADACION DE SINTETICOS ABSORBIBLES FECHA: 27- FEB-18
ACIDO POLIGLICOLICO CALIBRE: 1 LOTE: S180049

PRUEBA COMPARATIVA A DETERMINADOS DIAS , DIFERENTES TEMPERATURAS

PROVEEDOR DE MATERIA PRIMA GUNZE

20-Feb-18 27-Feb-18
14 DIAS-
INICIAL 7 DIAS- 43°C 37°C
1 8.821 5.850 4.048 x y
2 8.153 5.600 4.931 0 100
3 8.282 6.362 3.902 7 65.1
4 8.252 5.130 2.953 14 45.8
5 8.072 4.693 2.856
6 8.148 6.615 4.553
120
7 8.620 5.544 4.062
8 9.913 5.084 4.064
100 100
9 8.770 5.404 4.416 f(x) = - 3.8714285714x + 97.4
10 8.129 6.276 3.664
80
11 8.660 4.561 4.521
12 5.593 5.560 2.961 65.1
60
PROM 8.534 5.557 3.911
DESV-STD 0.512 0.642 0.684 45.8
40
MAX 9.913 6.615 4.931
MIN 8.072 4.561 2.856
20
% RETENCION 100.0% 65.1% 45.8%

0
0 2 4 6 8 10 12 14 16

REALIZO:
JULIO VALDEZ
45.8

16