‘Los nimetos entre carchetes refieren los capitlos de los colaborado- es exritos por ellos solos o en coautorfa Profewor of Medicine and Public Health, Asoite Provost and Asst Dean for Faulty fais: Interim Cie, lafctious Diseases, Drexel UniversiyCllege tf Medicine, Philadelphia [124,125] _Joros G Acne me, ener, MD ‘Welkome Trust Ciniian Sent, Department of Medicine and Insitute of (Child Health, Universi College London, London, UR (828) Jous W. ADUISON, a acct Viee President for Research, Direc, Blood Research Isis, Blood Center of Souesters Wisconsin, Mian (5,90 Das 4, Ansoust, Profawot of Medicine, Mayo Clinic College of Medicine: Constant in Gas troemteroogy. Ditisn of Casrocnterolgy and Hepatology, May Clinic, Ror chener [38] Lass ALAKosxo, sm, 0 Profewor of Medicine, Genter for Gene Therapy, Tulane University Health ‘Sciences Center, New Orleans [42] [Rayer C. ANDERSON, MD hich Dision of Hematcloyie Neopia; Director. Jerome Lipper Multiple Mein, Cente Dano-arbet Cancer Itt: Krat Family Profesor of Mei ce, Harvard Medical School, Boson (98, 9], Euuorr M. Avr, Profesor of Medicine, Harvard Medial School Directo, Samuel. Levine ‘Cardio Uni, Bigham and Women's Hospi, Boxon (228) aspemck R APPmtaAt, > Member and Director Clie! Research Dison, Fred Hutchinson Cancer Re- search Center, Profesor and Head, Dison of Medical Oncology, Univers of Washington School of Medicine, Seat [10] Gonoos L. ARciew Profewor of Meine and Micoboloy/Immmnolgy; Chair, Dion of nfec- Tins Daca, Department of Mei, Virginia Commonwealth University Medial Center, Ruekmond [118] Jou 0. Anurics, wo Jor Shapiro Profesor of Medicine, Unites of Nebraska, Ona [97] AAnrnur K ASBURY, MD ‘Yan Meter Profesor of Nenroogy inti, University of FennyaniaSehoot ‘of Meine, Philadelphia (22 368, 863 Jone R. ASN, 30 ‘sian Profesor of Medicine, Seton of Nephrology University af Chicago Poker School of Medicine, Chicago (265, 208] Jouy C. AruexrON, > Profesor of Gastoenterology, Wollion Digestive Diseases Cane and Ista ‘lafzesonsImmusiy and Tnftasimaion, Univers of Noting, Noting am England (125), act S. ALINACH, ys nical Profesor of Stgery, Department of Surgery, Dison of Emergency Medicine, Sanford University School of Medicine, Lov Altos [878] PR AUSTEN MD Aurateneca Profesor of Resprsory and Inflammatory Disease, Harvard Me- Gia Schon; Director, nammation and ADergi Diseases Research Section, Dison of Rheunaolagy,Immenotogy, and Aer, Department of Medicine, Brigham and Women’s Hospital, Boston [28], a TVV TILT ss BuRxano M. Baton, wo, md Profewor and Heat Dizon of Biochemissy, Department of Moleclar and Eaperinental Medicine, The Seripps Research Isat, Ea Jolla [92 Lisosey R BADEN, ‘Acieant Profesor of Medicine, Harvard Medial Schoo Divison of aeons Diseases, Brigham ad Women's Hospital. Boston (162) Rout E Bane, 0 Profesor and Chait, Department of lteral Medicine, American Universi of Bett (Lebanon): Atendng Physician, American Unversity of Beirut Medal Center, Bert, Lebanon [267 Doxa 8, Bans 2 Profesor of Medicine, Harvard Medical Shook Directo, Center for Iter fon of Medicine and lanovave Technology. Brigham and Women's Homa Bowon (212.229), ‘Rosuxr L Baran, x0 Fate Macy La Profesor of Obstet, Gynecology and Repredtive Bly Harvard Medical Schook Chairman, Obstetrics abd Gynecology, Brighars and ‘amen’ Hospital, Boson (5) "Town E BAR, wo Asocite Profesor of Medicine, Boston Universi Schoo of Meine, Boston (006,189) Fenner J. Burr Director, Graduate Schoo! of Puble Heath, Professor of Epidemiology and Biosastis, Sa Diego State Universi. San Diego [107] Shu 8. Basson, S Epidemiologis:, Dison of Presenve Medicine, Bigham and Women's Hosp ta, Bouse (827) M. Fur Bra, 0 Ane Pars Tie Profesor and Chai, Department of Nenology and Neuro ‘Gene, Weil Meta! College of Cornell University: Neurolgistn-Chie, New ‘ork Presierian Hopital, Nee York [945 955] Nicos J. BERCHING, RCH RACH DCH, TA ‘Senior Lecturer in ffetous Dieses, Liserpool School of Tropical Meicine: (Chica Lead Tropa an Infectious Disease Unit Ra Liverpool Univesity spit, Liverpool Cited Kingdom [141] Ronis S. Braj, Profesor of Bleicne, Chairman, Deparment of Sarcoma Medical Oncology, “The Univesity of Texas MD Anderson, Houston (84), Jous E, Bowxerr, Head, linia Mycology Section, Laboratory of ClnkcalInvesgation, Nationa Tnatae fle and Infections Dieses, Nana natintes of Health, Poso- sac (182190) nyano J Bex, J MD Richard and Susan Snih Pofewor of Medicine, Profesor of Peas, Prox fewor of Pathology Harvard Medical School, President and CEO, Danze Farber Caner Insite Director, Dana-Farber Harvard Cancer Center, ston i SuALeNoan Bests Profonor of Medicine, Univers of Calfraia Los Angeles School of Nest ‘Se; Chet Divson of Endocrinology, Charles R. Drew Univer, Ls Angeles 1535) Dav R. Brest, xo (Carl Truman Neion ioesor and Ch, Departmen of Dermatlogy, Cole [Ot Pincans and Surgeons. Colunbia University Medical Center, New York (st) wHew J. Beer, wo Profesor of Meine, Profesor of Cellular and Molecular Phyiology Yale Uk sens, New Hen [7 ‘Tons D. Bo, wo Profesor of Newology and Medicine, Uninersiy of Washington: Vterany At ‘as Puget Sound Medical Gente, Seattle 350, 64] Naw BuackLow, ao (Chairman Emertn, Deparment of Meine, Prfewr of Nesicine, Univer siy of Nasachusets Medial School, Wrcee;Vsting Profesor of Neticine, arard Medial Schon, Boston (168) Mawr J. Base, (Chairman, Department of Medicine, Frederick H. King Profesor of Internal Metin; Profesor of Microbiology, New York Univers Schoo of Medicine, New York [15,189) Guana D. Beoose, 10> Wiliam 6. Pace TI Profestr of Cancer Research, Cancer Seiad Seniot Advisor. The Ohio Sete Universiy Conprehemeve Cancer ad The Achat Jpmes Cancer Hospital and Richard}. Slove Resarh nate, Caan (6) Rucrarn S. Bux, (hie, Division of Gastroenterology, Hepatology, and Endoscopy; Brigham and Women’s Hospial, ston [276], Dow M. Boots, mo Chief, Hematopoiesis Section, Genetics and Molecular Biology Branch, Nate ral Human Genome Research Insite, Bebexd [5] Jess L Bowocws, Profesor of Dennatogs Yale Unters Schoo of Medicine, New Haven (48), Gronct J. Bost, Chairman. Department of Mein, Memorial Shar-Kexering Cancer Cente Profesor of Medicine, Weil Medal Clee of Cornell Universi, New York, os RuctanD C. Rove, Ja. 60 William Rand Kenan Profesor of Medicine, University of North Caroline a (Gap! Hil Director, University of North Carolina Cyse bros Cente, Cha pel in (241) ‘Kany D. BeaDss 40 Profesor of Obsexics/Gmecology and Surgers Helen Jan Robert Saws and Diana K.and Richard C, Sass Distinguished Profesor in Women's ea, The University of Texas Southwestern Meal Center, Ds (325) Luan R. ReaD, nn, Pn, rRcRE Profesor and Head, Department of Medicine and Therapeutics, Unversity Go- Nege Dublin, Dba, rela [25 64] Kegon D, BRANDT, MD Profesor of Medicine and Profesor of Orchopaedie Surgery, Indiana Univer sity School of Medien: Deco. ndiana University Mulippose Arian Musculoskeletal Diseases Center, Indanapolis (8 GENE BRAeWeALD, MD, (en, M(H, S00) Distinguished Hersey Profesor of Medicine, Harard Mel Schoo}: Chair ‘man, THM! Study Group, Brigham and Women’s Hosp, Boson (9,3, 32 208, 200,215,216, 21,221,292, 26298) Tnwrs M, Bre, 0 Profesor of Deroatalogy, Yale Univers Schoo of Meine, New Haven [18], (Ons W Busway, a Profesor of Hematology, Oncology nd Fpidemiology, Emory Univesity Med> al School, Aseiate Director, Population Sciences and Cancer Control roe im, Winship Cancer Institute, Anta [67], Jon. 6. Barus, 0, re ‘Setior Scenic Adin, Feary ternational Cenc, Nationa Inte of Health, Retest (195), [Bagay M. Ber, 1, s(t), MSH) Samuel A, Levine Profesor of Medicine, Harard Medical Schook Director Fieri Renal Diss, Brigham and Women’s Hoyptal, Boson (4041, 250- 252, 64, 2,267,270), Rorexr M. Beewses, xo Aocate Medical Director, lineal Reearch, Amgen In, Thousand Ou, Co rai [259] Groscr J. Baswex, Mortons and Henriena K Seller Ate Emeritus Profesor of Human Gene tis Act Emits Profesor of Intemal Medicine, Unersity of Michigan Me- ‘ial School, Ann Arbor [889] F.Recwo Bravos, 0 Arte Profesor of Medicine, Harvatd Medical Scio, ston ($81) (Guam V. Broome, x0 Senioe Adon, Centr for DieateContal and Prevention, ian [198] [ROMEETH. BROWN, J MO, ns Awocite Neurologist, Naschsets General Hopital Profesor of Neurology Harvard Medical Sehoo, Reson (358 368) Gnrcony Betsey, Mark M Ravitch Profs of Surgery. The Johns Hopkins Univers School of Medicine, Baki [27] 1H, Prawn Bey, wo Profetr of Medicine, Harvard Medical School, Boston 02 98), Dav M. Bers, 0 Profesor of Fay and Preventive Medicine, Profesor of Medicine, Univer of California San Diego, San Diego [875] Mics J. Bows, no Acisant Profesor of Meine, Harvard Medal School, Boston [377] Jou R. BurrERrON, ND, DIABaL Asin Profesor of Medicine, Harvard Metical Schoo stant in Medicine, Infectious Disease Dion, Masachuseus General Hospi, Boson [113] Jou €. Bin, so Warren Brown Professor of Leukemia Research Associate Profesor of Med «ine and Mediel Chemis, The Ohio State Caters: Director of Hematol- se Malignancies, Divison of Hematology and Oncology James Cancer Hospital nd SoloreReseareh Inte, Clubs [96] Sane B. CLDeRWOOD, MO (Chie, Divison of Infections Diesen, Marachnnets General Hoyt; Profee sor of Medicine (Microbiology and Molecular Genetic), Harvard) Mea School, Boston [118], MICHAEL ¥, CALLA uD, MSP, oT Progra Leader, Biological Threat Defense, Cente for Integration of Medicine and lasoative Technologie, Mawsiciets General Hospital, Boson (18) Mus Costs, Mo Atherton and Winred W. Bean Profesor, Profesor of Melcine and Pix logy, Mayo Cline Collegeof Medicine; Consultant in Gastroenerology, Mayo lini, Rochester (5) G. Dovaiss Casati, wo Profesor of Medicine, Director Divison of Pulmonary, Creal Care, and Ske Mescine, University of Miseppi Schoo of Medline, Jackson (296), GGnaxr L Cuant, 0, > Chie: Epiderilogy Actin, Arbvirs Diseases Branch, Dison of etor Bors be Infectious Diseases, National Center fr Infectious Diseases, Cee for De ease Contrl and Prevention, Fort Clin (149)CCunisrorn P, CANON, MD Awocate Profewor of Medicine, Hara Medial School See favestigaton, {TIM Sy Group, Cardonscune Dison, Brigham and Women’s Hospital, Bossx (277, ‘Manx D. Caso, Profesor of Medicine, Asocit Vie President for Goverment Relaons, se Wesera Reserve Univers Associate Dean, Case School of Medicine, Clee- Tana (20), (Crususs B. Camere, NO Proewo of Mediine, Harvard Medical School SenioePosician, Bihan and Women’s Hospial, Boon (258) ‘Bruce R. Coes, Professrand Ditecr, Division of Reproduce Endocrinology an ner Holder, Pau MacDonald Distinguished Chair in Obsetries and Gmecolgy “The Univery of Tex Southwestern Medial Center, Daas [325 Acusoy CastELLaNos, 00 Profesor of Medicine, Director, Ciel Bectrophosiology, Unies of la Sool of Medicine, Miami [256], Panu F Cras Mo Profesor ofPediats and Neurology, Unites of Washingon Schoo of Me- Alcin: Chie, Dison of Genetics and Development, Children's Hospital and Regional Meal Cener, Seale (964) Fence Gx, Profesor, Department of Medicine, Naonal Defense Medical Center: Chie Division of Infections Dieses ad Tropical Medicine, Department of Tnteral Medicine, TService General Hospital Tape, Tava 152] Yous: Ts0Ne CE, Mo, MD Profesor and Chit, Dion of Medical Genetics Duke University Meal Center, Director, Insite of Biomedical Sciences, Durham [340] Joy S. mn, 0 ‘Ses Profewor of Meine Cardiology: Co Chie, Division of Cardiology, David Geffen Scho! of Medicine at UCLA: Director, Aansou UCLA Adu Congenital Heart Disease Center, UCLA Metical Centr, Los Angele 218] Keraune G. Coma, ‘Asian Profesor, Department of Dermatology, Emory University, ln (78) ‘Oumien M. Cxostow, uo, Department of internal Medicine, pital Pi Salpriv, Pari, France (50) Runoro T. CHUNG, sistant Profewor of Medicine, Harard Mel School Director Heptolgy ‘Souee, Medial Director Ling Tratsplan Program, Asociae Physician, Mat sachusere General Hospi Boston (88) Frumuc L. Cor. xo Profesor of Medicine and Physiology, University of Chicago Pier School of Medicine, Chicago (205,268, ALANS. Come, 0 Distinguished Profesor of Medicine in Rheuatlogy, Emerits, Boston Uni ‘esiy Schoo of Medicine, Boston [10] Jama. Come, 0 Head. Media! Violgy Secon, Laboratory of Infectious Diseases, National Insite of Allergy and Tafecdous Diseases, National Insies of Heal, Bet esa (165,175) rancs S. CouLNS, MD, FD Direc, National Funan Genome Research Ins, Naonal Innes of Hak, Bethesda (68) Wausox S. Contec, mo, acc, Pa ‘Thomas J. Ryan Pofewor of Medicine, Bston Universi School of Medicine; Chie, Canionscular Medicine, Boston University Medical Cente, Boson (2 Jon. D. Coots, > Trans A. Graham Profesor of Surety, Department of Sarger, Diviion of Ca iotorale Sager, Washingon University School o Medicine, St Loui (208) Mx D. Coren, wo Profesor of Medicine, Perc, and Misobiology; Howard Hughes Medial nate Lvestiguor, University of Alabama at Birmgham, Birmingham [297), Mica J- Conse, i, set, Bi FRCP, ead, Dison of Bacteriology, National st for Biolog! Standards and onto, Psters Bar, United Kingdom [14] ‘Loner Comey, 00 ‘rafter Medicine and Laboratory Medicine: Head, Virology Dion, Unite Sty of Wabinglon; Head, Program in Infectious Diseases, Fed Hutchison Cancer Research Genter, Seattle (168, 79) Frusia Cosi ‘Atsociate Potessor of incl Medicine, Columbia Universi Collegeof Ph {Gams an! Sorgeons, Media Dien, Cinal Research Center, Helen Haves ‘spit, West Haverty New York [883] Manx A. Cancer, no Profesor of Medicine, Harvard Medal Schoo Pnscan, Brigham a Wo- en's Hospital, Bonn (28, 232] Prom . Cave, Irene E and Michal M, Karl Profesor of Eadocrnology and Metabolism in Medicine, Washington Univesity School of Medicine, St. Lous (54) Ronin G. Cesta, x0 Profenoc and Chair Departnent of Genet Medeine, Weil Meal College of Cornell Unersigg Chie, Dison of Pulmonary and Crital Care Medicine. ‘New York Pesytevian spt el Cornell Medial Center, New York (30), Jou J. Coste, mo Medial Diretr, ache Center, Presbyterian Hospi of Dall, Dals I) Gunuss A. Casi, , Profesor of Meditine, Harvard edicl School Chi, Dison of Step Ned ‘ne: Director Sleep Disorders and Greaian Medi, Brigham and Women's ovpital, Boson [24] ‘Manos ©. Duaxss, mo Profenor of Neurology. Chie, Neuromuscular Diseases Section, Naonal Ins tte of Newological Dooders and Soke, National Isitesof Heath Betbew a (968) Jost Dana, xo, 0 ‘Arsocite Profesor of Neurulogy, Depaunent of Neurology, Univesty of Pennoyhania, Philadelphia (87) asus. F Dana MD Profewor and Chai Department of Emergeney Medicine, Universi of Lo sill School of Medicine, Louse [19] Ronen B. Dagorr, 0 Profexor of Neurology ad Awocate Dean, Case Western Reserve Universi School of Medicine, Cleeand (2) Guauss E. Davis, > Profesor of Pathology and Meine Emi, Unversity of California San Dic fu ehool of Medicine, Director Emery Mobislogy Laboratory, Univers (fCaliforoia San Diego Medical Center, San Diego [12] ‘Sreves R. Derreut, 0 “ead, Secon of Hematology and Coagulation Medicine, Departnet of He tmaology Medical Oncology, The Cleveland Cine Foundation, Geveland [103] Jones Dat Vane, Profesor and Senior Awocite Chair of Medicine, Graduate Medical Eu tion, Department of internal Medicine, University of ichigan Health Syste, ‘nn Aor [273Martos R. DeLowe, 0 Timonie Profesor of Newology: Dire of Newroscence, Emory Universi ‘School of Medicine, Alana [381] Maur Desa en Asociate Profestr of Medicine, Harvard Mesical Sc, Howton [881] Broury M, Deen, Assitant Profesor of Medicine, Harvard Medial Schoo; Awociate Physician, Bigham and Women’s Hospital, Boston (4), Daw T. Dex, mo, wes Faculy Aine, Department of Microbiology. Colorado State Univers, Med- ‘al Epidemiologi, Divison of Vector arn lnfectous Dees, Center for ‘ease Control and Prevention, Fort Calis (148,156), RonemrJ. Deswck, uo, a0 Profesor and Chai Department of Human Genctics, Mount Sita Shot of Mes of New York Univer New ork [997 Berry Duos, M0 Chie. Dison of Rheumatology, Department of Microbiology and Immuno logy, Abert lnstein Collegeof Meine, New York [299] Jeuss L Duss, ao Profesor of Medicine, Harvard Medical Schoo: Physician, Maachusets Gene sal Hopital, Boston [78, 285287, 2011 ‘rizr Dion, Mo Profewor of Radiology, Section Chef, Neuroradiology, Vice-Chair for Research Racolog, Universi of California Sun Franco, San Francie [347] ‘Couauss A. Disanenz0, a Profesor of Neleine, Uae of Colorado Heath Sciences Center, Demet 8) Rows 6. Dun, Mo Profesor of Medicine, Harvard Medal Schon), righ and Women’s Hosp ta Boston (821, amt Douay, an Massel Finland Pofeuor of Medicine (Microbiology and Molecular Genetic ‘ean for Academie and Clinical Programs, Harvard Medial School, Boston 162,170,171), Davo M. Dosa, um, Aint Profesor of Medicine, Brown Medical School: Divion of Gerais, ‘Rhode land Hopital, Providence (8), Date B, Desc, x Profesor of Neurology and Newoscence: WW Smith Charble Fowndation| Profesor of Neurigmmanolog, Director, Neuromuscular Unit The Johns Hopkins Universi Scio of Medicine, Balimore (366) Jerry M. Daas, x Profesor of Medicine, Harvard Medical Sehool, Boson 283285, 252) ‘Tuows D. Dusost, Je Mo Profesor and Chair, Department of Internal Medicine, Profewor, Departnent of Physiology and Pharmacology, Wake Forest Univenity School of Meine, ‘Winsor Sen (42) J. Sree Down, Profesor, Divison of Medial Merobiology; Department of Pathology ad the Program in Cellar and Molecular Medine, The Joins Hopkins Universiy School of Medicine: Deparment of Moleelar Microbiology ad nxmunoogy, “The Johns Hopkins University Blooeberg School of Puble Health, Batiore ass) Axon E. DUNAt, (CharesFKenering Profesor of Medicine, Northwestern Unies Feinberg Schoo of Medicine! Chit, Deeson of Endocrinology, Metab axl Molec har Medicine, Nontesern Universi, Chica (5) Sue. € Duwo, xo Associate Profesor of Medicine, Dison of Geriatric Medicine and Gero logy The Joins Hopkins University Schoo! of Medicine: Depury Ditector of Encaion, CoDicecor Fellowship Training Program, Director of Ambulatory ‘lsia Serves, Baltimore (25) occ P Durca, wo Profesor of Mein, New York Meal College: Asociae Dizeto, linia Ars Our Lady of Merey Cancer Center, roms [8] Jou T. Bort, Ds Professor of Medicine and Community Heath, Tus University Schoo of Me ‘ine and Friedman Schoo! of Nutrton: Directo. Frances Sters Notion Cen- ter; TufteNew England Medical Center Senior Scien; Nutritional Epidemiology Program, Jean Mager USDA Huan Nutrition Center on Aging a Ty, Boson (60) ‘Victor J. Daa, wo Hershey Profesor of Medicine, Harv Medical Schoo: Chairman, Depart ment of Medicine and Director of Reach, Brigham and Women’s Hospital, Boston (281,282) JerrmnS. Dacrxows, 0 Physician, New Briain General Hopital, New Britain 19) J. Donato Bssto, > Profesor and Chai, Department of Glncal Neurosciences, Brow Media School and Rhode land Heap, Prondence (340) Dos A. Esme, Associate Profesor, Section of Endocinslogy, Deparment of Medicine, Unk ‘ey of Chicago Prither Schoo of Meine, Ckago (44) Exo J. anon, oy m0 (Chief Deparment of incl Bioethics Warren G. Mageuson Clini Center, ‘Naina Insts of Health, Bethesda (9), Lino L. Exavvnt, Buehler Profesor of Geriatric Medicine, Director, Buehler Center on Aging, [Northwestern University School of Meine, Chica 9) Jour W:Evostaow, Profesor of Neurology: Vee Chairman, Resideney Program Director University ‘Calon San Franc, San Fine (1 524] Axmowr 8. auc, Mo (Chie, Laboratory of mmunorulason: Director, National Insite of Alergy and Infeesous Diseases, National Insts of Heath, Bethe [172 175,25, 285,506), Musa J. Bos, Presa of Medicine, Universty of Chicago Prake Scho! of Meine, Dik Sion of Holgi Sdences, Chicago [268,53 Rosser G.Fexro, , r> Associate Profesor of Medivine, Universi of Maryland Greenebaum Cancer Cente, Baiove [68] Hows L: Fes, wo, 0 Profesor of Neurology and Physiology, Ushers of California San Fran, San Francie [11] Grecoms A. Praca, 0 hie, Infectious Disease Section, Veterans AMfuirs Medical Comer: Asoci te Profewor, Deparment of Medicine, University of Minnesota, Minneapolis 16) ‘Ronsr W, FIsmexe Profesor and Chair Department of Medicine, University of Mawschistts Me- Aiea School, Worcester (72,117), Jove D. Pincenorn, ao “Asssant Profesor of Medicine, Harvard Meal School: Division of lnfctious Diseases, Beth Ina Deaconew Medial Center, Beston (117)sow DL Fst, wo Asitant Profeon, Harvard Metal School: Director, Hypertension Service, ‘Brigham and Women’s Henpial, Box (250) Jemma S. Fume, x0 (Chet Academic Ofcer Beth lel Deaconess Medical Center: George C. Rix tan Profesor of Medicine, Harard Medial Shoo, Boston [64] Sonia Fars, Mo Insracior of Medicine, Harvard Medical Sdhok, Associate Physician, Bigham and Women's Hospi, Boston [276] ‘az F, Pron, 0 JH Nicolon Profesor of Pediaies (Cardiology; Senior Asociate Dan for “Academic Aft, Divi Giffen School of Medicine at UCLA, Los Angeles [ais] Rona F Gace, mo rfesor of Mediine and Head, Dison of Tnerual Medicine, Universi of “Texas MD Anderson Cancer Center Houston (380) Jos 1 Guu, wo Director MH Warren Grant G. Magnuson Clinical Cente; NIH Asie Di rector for Cinial Research; Chie Laboratory of Host Defenses, National In ie of Allergy and Infectious Diseases, National Inatutes of Health, Bethesda (ssi Suses T. Geant Mo Assan Prfesor of Sargery, The Jobas Hopkins Universi Shoo of Medic ‘ne, Balimore (279) Roneer H. Gauss, 0 eoard Wood Memorial Séentie Director, American Leprowy Foundation: Cina Profesor of Medicine and Dermatology, Universi of California San Francie, San Franco [131] Jamey A. Gare, 0 ‘isting Profesor of Medicine, Harvard Medial School Profewor of Meine, Tufts Univer School of Medicine; Physician, Infectious Dieses Unit, De partment of Medicine, Mavsichwets General Hospi Baston 16,18) Dut N. Genwi, xo (hie, Medial Service, VA Chicago Health Cae StemLakesie Division; Pro- Fer and Asociate Chairman, Department of Medicine, The Feinberg Shook (of Medicine, Notwexern Universi, Chiao (114) ANNE A. Grasu0n, > Profeabr of Petites; Director, Dison of Pediatric Infectious Diseases, Coe bia University Medial Center New York (176178) Mane Gane, Medical Sta Fellow, Liver Dieaes Section, Digesine Dieses Branch, National Insite of Diabetes and Digsine an Kidney Diseases, National Intute of eal, Bethesda (282) -Ranono J. Gaon, M0 “Arthur Mand Gay D, Gray Proeser af Medicine, Mayo Clinic College of Medicine, Roches [211] Barve C GuAND, xD Profesor of Meticne and Labo School of Medicine, Seale [3,083 ory Medicine, Universi of Washington 316] Roce 1. Gis, , 0 Vital Casini ection, Centers for Disease Conrl and Prevention, Aline (174) Bu GLarstay, wo orion M.Kigerman Profenor and Vice Chairman, linia Director, Depar- ment of Ration Oncology, Univer of Pennsania Medial Center, Pile Adelphia (71,207) Rone M. GuCAN, Mo Profesor of Meine and Dean, Nev York Unkersty School of Medicine: CEO ‘ew York Univer Hoga Cente, New York [29] Jos F Groceyt, xo Assistant Profesor of Radio, Mayo Clinic Collegeof Meine; Constant, Depurtnent of Radiology, Mayo Clinic, Rocheser [211] gv L Coummenci, so ‘Asociate Profesor of Medicine, Harvard Medial School Dnetor, Margret and HA. Rey Instat for Nolieae Dynamics Medicine, Beth rel Deaco- ess Medical Centr Boston (210) SiWuH. 2, Gouna, wo Amocisie Profesor of Medicine, Harard Medial Sehook Directo, enous ‘Thromboembui Reerch Group Deer Aniooagultion Service and Stall Cardiologist, Brigham and Women's Hospital, Boston [24] Raven Gonz, un, sr Awa Profesor of Meine, Epidemiology and Biostatistics, University of (alfornia San Fancsco, San Francisco [27 Douctas Cooney, so Profesor of Neurology. Unversiy of California San Franco, San Francisco (59) Ry K Gort, Mo Malin Profesor of Medicine, Harvard Medial School, Boson [8,273] Gascosy A. Gaasowss, Md Director, Division and Program ia Human Genetics, Cineinat Children’s Hos pital Resear Foundation; Profewor, Deparment of Pediatrics, and Molecular Genetis and Biochemistry, Unversity of GncinaatCalege of Medicine, Cn- ‘inna (40), Jpoon Gra, uo ‘sacs Professor of Meixine, Deartnent of Nephrology, Techn Facly (of Medicine, Haare (261, [Nowrox J. Gnsesnencan, wo Profesor of Medicine Harvard Medical chook Senior Physician, Bigham ad Womens Howie, Boston (292.294) Dov E. Guten, wo ‘Director of Tuberculosis Series and Profewor of Medicine, University of Te sae Health Center Tr (148) ‘WanLL Gnossu, 0 Mier Friedman Distinguished Profesor of Medicine, Univesity of California, Sin Famcno Chi of Cantilo Univers of California Sm Francisco Me ical Center Sa Feansco [212] Rasim Gueauy, a ‘Awodiate Professor of Medicine, Department of Oncology Montefiore Medial ‘Gener. Abert Einstel Collegeof Medicine, New York (58) Brym Haars Hans, Profesor of Medicine, Did Geffen School of Medicine atthe University of Ca Iioria Lan Angeles Ln Angeles [300] Stem M. HAS, a0 ‘Associate Profesor, Department of Ra logy Oncology, Univer of Pensa Division of Hemato Philadelphia [71] Jove EH, ‘Associ Proleuor of Meicine, Harard Medical Scho: Asian Physician, Masachisets General Hospital, Boson [45] Jesse B. Hatt, Seton Chie, Pulmonary and Creal Care Medicine; Pofewor of Medicine Abesthess and Criteal Cae, Unters of Chicago, Chicago (249) Soorr A. Haven, up Professor of Feat; Anvocate Profesor of Microbiology and Iomnolog, Dathouse Universi Half, Nova Sra, Canada (13)Guanits H. Haste, Profesor of Internal Medicine and Nui, Univers of Cafornia Davis Stool of Medien, Das (52) Romer HANOI, wo Profesor of Medicine, Harerd Medial School, Heston (58, 101, 13] Carats A. Histon, va, ro Vetrnary Medica Officer. Rabies Section, Centers for Diese Contra and Prevention, Adana (173), (Gain Has, wo, rn Director, STD Services, Royal Adee Hospi Clinical Anodate Profesor, School of Medicine, Rinders Universi, Adelaide, South Auta, Atala us) ‘Writ L, Hasire, wo Asa Profesor of Intel Medicine, sion of Gantranterolyy, Univer si of Michigan Medical Center An Aer [34271] ‘Tawy J. Hasso, AD Profesor of Genetic, Case Western Reserve University Schoo of Meine, Ce veland (37) Samo L, Hausen, wo Robert A. Fishman Dsagulshd Profesorand Chairman, Deparment of Ne tology, Univesity Calornia San Franco, San Fran [45,346,385 35, ssh ian B. Hos, > Medial Epidemiologist, Dison of VectoBorne Iafetoas Dien, Centers {or Disease Gonol and Prevention, Fore Calis [156), Roerow F Hass, wo Freerie M. Hanes Profesor af Medline, Professir of immunology Duke Uk very School of Medicine, Durham [205] J Cesvoe Hass ll, wo sistant Profesor of Neurology, Univers of Calflora Su Francbeos Die ‘or, Neworascular and Neurerical Care Program, San Francs General Hor pital, San Francico (258) armies H. Hey, > Principal estar, St. LouisCape Grades Community Clinical Oncology Program, S.Louts (34) ‘Baguane L, Hewat, sm, Medial Epidemiologist, Dison of Parse Divas, Centers for Disease Co tw and Prevention, ana [196] Masry, Huns, Profesor of Medicine, Harard Medical Schook Profesor of lnmunology and Infectiows Dieaes, Harvard Scho of Pai Health; Director of Cina AIDS Research Massachusetts General Hoypitl, Boson [165] Hon HLskeL, Hos, x Invesigaor, Howard Hoghes Medical Issue Profesor of internal Medicine tnd Moleeular Geneticy, University of Texas Sonnets Medical Center, Dat Tas 385) Joon $. Hoan, 0, race Harold Sader Fam Profesor of Cardiology; Cinicl Cie, Dison of Ca slog: Director, Carovascular Clinical Research Ne Yrk Unies Schoo of Medicine, New York [283 Srey M. Hous, Seuioc lnvesigaor and Head, Immnopathogeness Uni. Cine Pathophe ‘ology Seen, Laboratory of Hos Defenses Nntonal Insite of Aer nd Infectious Diseases, Nao Tsu of Health, Bethesda (55) Kine K. Hots, wo, mp restora Medicine; Direc, Center for AIDS and Sealy Transmit i sezes, Universi of Wishingon, Sete [115], sont. K KOU, no, AD Profesor and Cif) Deparment of Microbiology, University of Colorado “eakt Sciences Center, Dever (122) Jv H. Hoorscte, 0 Director, Liner Diese Research Branch, Dison of Digestive Diwases ane Noe tetion, National Instine of Diabetes nd Digeive and Kidney Diente, Ntio- ral Insines of Hest, Bethe 283) [Roser]. Hore, > Aina Profesor of Clinica Pais, The Univesity of Cnenna Callege ‘of Metin; Dison and Program in Human Geseies, Ginclana Childrens spit Resarch Foundation, Cincia (340) Joxaniay ¢. Horo, 0, m9 Wiliam F Hoy Profesor of Neuro Ophthalmology, Departments of Opal mology. Neurology and Pisiology, Unieriyof California Sa Franco, Sa Francisco [35] {Lax Hwan, sm, cr ners Profesor of Medicine, Asocat Profesor of Pda, Albany Me cal Calege, Alay (65) Homan He, 0, we, se Profesor of Occupational and Environmental Medicine, Department of Eas ‘onmental Healt, Harvard School f Puble Health AsodatePhsckin Chan- sing Laboratory, Deparment of Medica, Brigham and Women's Hospital Associate Professor of Medicine, Harvard Medical School Boston (578), Guay W. Howescia, Seria Profesor of Medicine, Director, Dison of Plenary Crt Care and ‘Occupational Medicine: Dicer, Gaduate Program in Tramlational Biomed ‘al Reseach, University flow College of Medicine, Lowa Ci [7] Swan A. Her, Profesor, Dison of Cardiowscular Medicine, Sunford Cnet, Sanfont Bi Gaus G. Huns, so Chief. Chemical Casuaky Care Dison, US Army Medial Research tne of ‘Chemica Defense Maryan (306) Dav H. Non, 0 Profesor: Medicine Physiology and Pediatrie: Deco, Pony ergy an (tal Care Dison, Univers of Minne, Minneapolis Envano PINcENITO, NO, PD Aswocate Physician, Brigham and Women's Hospi Adjunct Aan Profee sor Harvard Medical Schoo, Boson (250, 252] Rotasn H. ncaa J Martha Wes Looney Pafeso Emerita, Emory University Schoo! of Medicine Avant (29) Man A st, Profenor of Pediatrie und neti, Daunouth Metical School itectn, Nox ‘ris Couon Cancer Center, DatnouthHicheock Medial Center, Lebanon (358) Kimr J. Iosascaen, Disinguinhed Nallincrode Profesor of Medicine, Hard Medical Schoo} Prin and Ditectr, Massachuseus General Hospital Cancer Cemer, Box (8 288287, Rc F.Jscons, mw Horace €. Cabe Profesor of Pedic, University of Atanas for Medial Sciences Collegeof Mein; Chet Pediatie Infectious Dieses, Arants (hires Hopi, Lite Roc (142), J-Lansy Jssox, 0, 0 Irving $. Cater Professor and Car. Deparunent of Medeine, Northwestern Universi Feinberg School of Medicine: Physéan inGhit, Nowtwestern Me- modal Hosp, Chicago 36, 38 9,85, 31,318, 20 325, 25)Joss L jour, Je, xo ‘AnistantFrofeaor of Medicine, Harvard Medical School; Asian Physician, Dison of Cardiology and Departmen of Medicine, Masachusets General epltal,Boston(Apendices] Rowen T JENSEN, MD (Chief, Digestive Dsetzes Branch, National Insite of Diabetes and Digestive snd Kine Diseases, Nona Instaes of Heath, Bethesda [329] [Brvce E. JOUNSON, MO ‘Avocate Profesor of Medicine, Brigham ad Womens Hospital and Harvard Medial School Program Direttot Lowe Gener for Thoacie Oncology: Danae Faber Cancer Insite, Boston (88) SroatrJousos, mo ‘Anending Pian, Hines VA pita soca Profesor, Department of Me- “icine, Sitch School of Medicine Loyola Unser, Maywood, I [114] S. Camonse Jousst0%, MD, ma [Rnocate Profesor of Neurology and Epidemiology, Directo, Stroke Service Unnesy of Calformi San Francisco, San Francico (549) Ma E,Joserisox, mo Profesor of Medicine, Harvard Metal Sehool Chief Cardiascusr Dison, Beth Ise! Deaconess Medial Center. Dtecwx, Harvari-Thomdite Ble ‘eophysiologyInsitite andl Arhythmia Service, Boston (218, 214] Jouce L Jercos, 0 ‘Aodate Profesor of Newolog, Emory Utes Scho of Mein; Diese torof Neurology Weve Woods Hopital Aslan (851], Envoy L, Karas aD Profesor of Pedic, Univer of Minnesota Medical School, Minneapolis (302) Mansiats M. Karas, Profewor of Medicine, Tats Unies Schoo of Medicine, Boston [5,285], Abou W. Kurcrne, 0 Profesor of Medicine, Harvard Medica Schoo: Chet Dvion of Infections Diese Beth nae Deaconets Medial Center, Bestan (108) Danes L. Rasre, MD, (in) Willam Fler Channing Profesor of Medicine, Profesor of Microbiology and Moleelar Geneces Harvard Medial School Direc, Channing Laboratory, Deparment of Medicine Brigham and Women's Hospital, Bexion (104, 106, 112,195,131, 148) [Liowp HL Kssren Profewor of Medicine (Neurology) nd Mcrbiologs Immunology: Director, Malpl Sclerosis Center, Darunouth Medial Schoo, Lebanon. 188) DaSIEL L. RAstNtn, o, AD (Chief Gentes and Genomics Branch, National Insute of Ars and Mx ‘iostleal and Skin Diseases, NadonalInsutes of Health, Bethesa (278) BANE T: Ke, Clie Insractr in Dermatology, Harvard Meal Seiool Asian io Med tine Department of Medline, Childrens Hospial Meal Center, Boston [17] Reser M. Kav, mo “Asisant Profewor of Medicine, Harvard Medial School Associate Pisin, Dinsion of lnfecions Disenes Brigham and Women's Hospital, Bowen (17) Gon T. Kavsen, Assan Provost and Asciate Dean for Global Heath Profesor of Meicine fd International Hest, Boston University Medial Camps and School of Por ‘lic Heakh, Boston (107 138, 10] JJo’S. Kestox, wn, wso(cru), mre Profesor of Medicine, Univesity of Toronto; Tropical Dee Uni, Division of Infections Disease, Toronto General Hospital, University Healy Nework, To- onto, Ontario, Canada [108], ore KI, wo, 0 Harniet Ryan Alpe Profesor of Medicine and Microbiology and Molecular Ge- netic, Harvard Medical Schook Senior Physician, Bigham and Women's Hor lal, Boston 161] ‘Tawaner E KING, J Mo “The Constance B, Waly Disingvished Profesor and Vice Chatman, Depart ment of Medicine, Universi of California San Francico; Chie, Medical Sere fs Son Francisco General Hospi, San Francsen [245], {Loc V KiReuH09%; uo, Me Profewor, Departments of Internal Medicine and Epidemiolo, Univers of Toa Saf Physician, Departs of Veterans Aas Medial Center, fowa Gi m7 Jon. N. Kus, MD, 5 Profesor, Director Unters of ona Adult Asma Center, Universit of fova allege of Medicine, Ina Ci 287] Howaaw K Kor, 0, mp Prafewor and Asoiate Dea, Harard School of Public Health, Boson [73] Dryas J. Korncxo, > (hich Laboratory of Enteric and Sexy Transit! Diseases, Center for Bio- logis Evaluation and Research, Nadoual Insists of Heath, Bethesda 138] Peter Kore, “Asociate Profesor, Dison of Endocrinology Metabolism, and Moleelar Me dine, Norhwesero University Feinberg School of Medicine, Chicago (55) ‘Wars J Konoserrz, “Vee Chal, Neurology Service, Masachasers General Hospital, Ascite Pro {esr of Neurol Harvard Medial Schoo, Boston (361) ‘Puvuus E. Rozatsi, Mo Profesor of Medicine Infectious Diseases, Emory University School of Mick ‘ie, Chic,Taeler's Health, Dision of Global Migration and Quaraine, Ce ‘ers for Disense Cool and Prevenidon, Alaa (108) Buwwerr S. Ku0de, MD, MPa Asda Director fr Dine Prevention, National Instat of Healthy; Clin Cal Profesor of Medicine, Uniformed Services Unversiy ofthe Health Scene es, Bethesda [67] Seeman ML KEAN, NO Peas Cyrus, and Maloy B, Haron Profewor of Medicine, Harard Metical School Physician and Chie, Arhrity Unt, Masochsets General Hospi, Boston (331) ALEXA KRATE, My, MPL Anintn Profenoro Pathology, Harvard Neil Sehoo: Director, Clinical He tology Laborstory, Matas General Hospital [Apéndices) ous P. Kans, no ‘Astant Profesor of Medicine, Uninersiy of Chicago Prize Schoo of Med fine, Chicago (249) Hieery M. KuosENaERC, MD Profeioeof Medicine, Harvard Medical Schoo; Chief, Endocrine Uni, Mass uses General Hospital, Boston [381] Lones Lar, Profesor of Meticine, Gastrointestinal Dison. Deparment of Medicine, Keck School of Medicine, Unersty of Souter California School of Medicine, Los Angeles [37 ANIL Lavi, x0 ‘Mendik Foundation Profewor and Chai, Department of Otlrygcogy: Pro- {este of Physiology and Neuroucience, New York Unnenity School of Medic= re, New Yor (25)Les Lanosaenc, > Profesor of Medicine, ean and Vice President for Mecicl Afr, Nortines ‘ern University Feinberg School of Medicine, Chicago (322) HL Curronp Lise, a Head, Clinica abd Molecular Rewosrology Seton; Laorstory of Imaunore ulation; lini Director, Naonal Insti of Alergy and Infections Dieses. ‘Naional loss of Heald, Bethesda (173, 208) Cxz01 A. Laxcrono, x0 Senior Investigator, mmunologe Diseases Sesion, NIAID, NIM, Rete (306), “Twowas J. Lowey, wo Dean, Etory Unierity Scho! of Medicine, Adana [5,47 49) Taos H, Ler, Mo Asoiate Profesor of Medicine, Harvard Meal School Chie Exeeie Oi cer Partner Community Health Cre, Inc; Network President, Parters Health (are, Boston (12) (Ore Lav, wo Atending Pisin, Department of Obstetrics andl Greco Tel Medi- al Cente, el 207] Caw F Less, a, 0 Asitant Profesor in Medicine, Harvard Medical Scho}, Cambridge (197) ‘Brvce D. Ley, un, race Asstt Professor of Meine, Harvard Meal Schoo: Pulmonary and Cr ‘al Cate Medicine, Brigham and Women's Hosp, Boston [251] Kexr 8 Lncixonowsx, Associate Chie of Pathology, Decor. Core Laboratory, Masachasts Genera opi; Associate Profesor, Harvard Medial School, Boston {Apencices) Peres Lins, Mallinckrodt Profesor of Medin, Harvard Medial School Chit, Condon ‘lar Meine, Brigham and Women’s Hospital, Boston (224, 825] Ricsato W. Lick, wo Profesor of Medicine, Vanderbilt Univers, Nase [245] (Cau Lay, AAwocate Professor of Medicine, Harvard Medial School Divon of Palo ‘ary and Grit Cae, Department of Medien, Brigham and Women's Hosp- ‘a, Bouton (250) CCimasrori H. LDS, > Profesor, Department of Emergeney Medicine, Divkion of Medical Taxicoly, Universi of Masochusets Medical School, Worcester [37] Roses Linon, ao, io Profesor of Clinical Medicine, Colimbia Unversity Cologe of Physicians and Surgeons Chie, Internal Medicine, Helen Hayes Hospital, Wess Haertan, New York (38), Marc E rms, 0 John G. Seale Profesor and Chair, Department of Intcnal Medicine, Univer St of Michigan Health System, Ann Arbor [76] Perer E Lise mo Seienifc Director, National Institue of Anis and Musculoskeletal and Skin Diseases, Nationa Institutes of Health, Bethesds (299, 0,311) Dix L. Loxco, Scene Director, National Instat on Aging, National sites of Health, Bethea apd Balimore (52,54, 66, 60, 70, 80,97, 08,172), Nicota Loxco, a, 0 Profesor of Pediaes and Director, Metabolic Serve, Dion of Medical Ge- neti, Department of Pediatrics. University of Ua, Salt Lake City (343, 385] Donut E. Low, uo (Chief, Deparment of Medicine, Toronto Media Laborstorien and Mount Si nai Hospital: Profesor of Meicine and Microbiology, Univer of Toronto, Toromio, Ontario, Canada (233) Pau A. Low, wo Profesor of Neurology Mayo Medical Schok Chairman, Dison of tinal Neuroposiolgy; Consultant in Neurology, Mayo Clinic, Rochester [854 Dain. H. Lovansta, sa Profesor of Neurology Vice Chatman, Deparment of Neurology: Direcor. PiyscanSciens Education and Training Program: Dcecor UCSF Epler Cente, University of California San Franciseo, San Francisco (346,34), Rou D. Lowy, 0 Profesor of edicine and Philo, Cakumbia Unters, New York 30] Suna A. Loser, ro Research Profesor, Univers of Washington, Sea [153,154] Lsmasce C. MABOFK Asian Profesor of Medicine, Harvard Medical Shoot Associate Phsktan, ‘Beighars and Women's Hoyptal, Boson (204, 125, 314) ‘poses H. Mace, (hie, Parase Diseases Branch, Comte for Diese Control and Prevention, Aaa [111 814, 978] ADELA. F- MAHMOUD, 10, 0 President, Merck Vaceines, Merck & Co, Incj Adjunct Profewor of Medicine, (ase Western Reserve Universit, Whitehouse Station (208) Roya V. Mater, 0 Profesor and Viee Chair Surgery, Univers of Washington: Surgeon Chie, Harborview Medial enter, Seat (258) Manx E: Manas, > Associate Profesor, Deparen of Internal Medicine, Universy of Nebraska Collegeof Medicine; Chet, Section of Gastroenterology, Omula Vewerans AP {airs Metical Geter, Omaha [288) {JOANN E. Manso, a, meee Profesor of Medicine andthe Eliabeth F. Brigham Prfewor of Women's Health, Harvard Medial Schoo: Chie, Dison of Preventive Medicine, Brg ‘ham and Wornen's Hospi. Boston (327) Busoni Maxaros Fu, wp Associate Profesor of Meine, Harvard Medical School: Chie Obesity See tion, fos Diabetes Center, Boston (64), axon. B. Mak Mo, Ht Profesor of Meine, Duk University Medial Center, Director, Outcomes Ree search, Duke Gia Research Itt, Durham (2, Taows J. Mansur, wo, mice Profs; Deparment of Medicine Dean Faculy of Medicine snd Denti, University of Albers. Edmonton Albers, Canada (158, 29], Gay J. Mare ‘Raymond J. Lagenback, MD, Profesor of Medicine, Vice Chairman, Depa _ment of Meine, Northwestern University Feinberg Schoo! of Medicine, Chi cago (4) Josera B. Maser, oo, m0, sa) Dean ofthe Fail of Medicine; Carlie Shields Walker Profesor of Neuo- ology and Clinical Neuroscience, Harvard Medical Schoo, Boson [1 $48) Rone J, Maren, Vice Cha for Aeadeie Afr Director Centr for Gastrointestinal Oncol Danauber Cancer Insite; Profesor of Medicine, Harvard Medial Scho Boson (7,73) CCawwny 0. MeCau, so Asscant Profesor of Demmatslogy, Department of Dermatology Emory Uni versiy School of Medicine, Adana (47)‘Win M, MeConsscr, 0 Profesor of Medicine Chie, Infeeous Diseases Dison, Sate Unersity of ‘New Vork Downstate Metical Center, New York [129] Reais McFADOES, Jt MD ‘Ang Bess Profesor of Medicine, MewoHealth Medical Gene, Cleveland (236) Roxun D.G, Mek, (Gh, Laboratory of Molecular Biology. Naina! Inset of Neuro ise ders and Soke, NIH, Bethesda (59), rT MeVany, mo Avoca Profesor of Urology. Northstar Unies Feinberg School of Me din, Chicago (48) Naver K. Mazo, 0 Profesor of Pcholagy, Harvard Metical School, Boston [37] Sutowo Masso, 0 Profewor and Awocate Dean, Dad Geffen Scho! of Medicine at Universi of California Lox Angele; Senior Vice Present and Chef Academic Ofer at (CedarSina Medial Cate, Los Angeles S18] Jay R, Maxon, a Helen C. Karr Profewor and Chairman of Neurology, Ohio State Univers (Columbus (367,368) {Jsck H, Maxosos, 0 Profesor of Pychiairy (Neuroscience), Hareard Medical School, Belmont (374) M.-Manse1 Mista, no Ruth and Evel Dunhar Profesor of Newology and Pychiay; Deco, Cene ter for Behavioral and Cognitive Neuolog: Dizecor, Aldheimer’s Program, ‘Norivetern University Feinberg School of Medicine, Chicago (23) Susy Must, > Maine Cente for Cancer Meine and Blood Disorder, Searbormugh 38] can L. Misono, Md Awocate Profesor of Medicine, Harard Medical School Brigham and Wor men's Hospital, Boston [365] Broce L. Matz, 0 AW and Mary Margaret Claien Disingulshed Chal, Profesor of Neurology, Universi of California San Francieo, San Franco (850,962 Manx Minus, ‘Assoiate Director for Research Director, Dion of International Epiderio- logy and Population Studies, Fogarty International Center, National Insists ‘of Heath, Bethesda [107] ‘Save, L Mitzna Profesor of Medicine, Microbiology, and Genome Siences, Unies of Was ington, Sate (197), Jou D. Mow, 0 Profesor of lncrnal Medicine and Pharmacology: Director Hamon Center for ‘Therapeutic Oncology Research, University of Texas Soudestem Medical (enue, Dallas 75] Tunas A. Moons wo, rice Gna Astociate Profesor of Medicine, University of Kamas Schoo of Medic ne, Wichita 195] ParJ- Mou, mo Tesi Nao! Iie on Ang, National srt of Healy Assan ‘Profeer, Deparment of Pathology, The Johns Hopkins Schoo! of Medicine, Balimore (68) Roses J. Mora Atendig Psa, Memorial lon Retr Cancer Cener Profesor of Mee icin, Weil Medical College of Gorell Unersi; New York (8, 82] Hiaraauros M. MovTsor0vL0s, Mb Profesor and Diretor, Deparment of Pathopiilogs, National University School of Mesicne: Presiden ofthe National Organization for Medicine, A Tens, Greece (904, 307) Rowse §. Moron, wo Jan and Hen Bromberg Profesr of Internal Medicine, Unters of Texas ‘Southwestern Medical Comer, Dallas (127, 254] ‘Tovory F Mummy, Distinguished Profesor of Meine: Chief Divison of nfetous Dieses, Ste te Uninerity of New York Bufo, Bull (180) ‘Dae, M, Muster, wo (Chie Infectios Diseases Seton, Veterans Aas Mea Cente: Profesor of Medicine, Profesor of Moleelar Virology and Immunology, Balor College of Medicine, Houston (19,129), ‘Ronen J. Murmur, 0 Lemberg Profesor of Medicine and Physiology, Dirt, Divison of Caron leg Unies of Mini Schl of Medicine: American Heart Asociaton, (Ohi n Cardenas Research, Mami (256) Grau T. Neos, x0, aD Director, Benarys Research Ite at Viginia Mason: Profewor (Ait), Deparment of lnmunology, Uninersiy of Washington School of Medicine, Seale (26) Joxanian Newnan Mo (Chie, Operation, Chemical Camaly Care, US Army Med Reach Inwir 1 of Chemical Defease, Marland [205] icin A. Nsuowuna, Jud an Mary Morts Leighton Profesor of Cardiovascular Diseases, Mayo Cit ‘ie Callege of Medicine, Rocheser (211) ‘Rosser L. Noms, Md AsnciateProfewor of Srger, Deparment of Surgery Divo of Emergency “Medicine, Stanford Uniersiy School of Medicine, Sanford 78) Trows B. Nena, 00 Head, Heiminth imunolgy Seton and Head, Clinical Parasitology Unit Lak trator of Parasitic Deas, National state of Allergy and Infections Diese ses, Nationa tats of Health, Bethesda (201,202) Rica J, ONE oD Head of Scene Elution, Foundation for Innovative New Diagnoses, Ge- rev, Swimerand (130) CCunsrorn A. Om, 0 Asociate Profesor of Medicine, Sesion of Infectious Diseases, Wake Foret University School of Medicine; Diretor, Center for Antimicrobial Utzon, Sterardship, and Epidemiology, Baptit Medical Center, Winston Salem (185), Ruano K. O1Ne Mo Profesor of Neurology. Unites of California San Frincso, San Franco en ‘Yeo M, O°Means iy RCP Senior Lecturer in Meticine, Unversity College Dublin; Consultant Nephrol- gi Mater Miericorde Hospital, Dublin, eland (254, Rosexr A. O'Rovrat, xb (Cres Conrad Brown Distinguished Profesor of Cardiovascular Science, Uni ‘eity of Teas Health Science Center at San Antonio, San Antoni [29] ‘Grune Owunc, a0 Profesor of Internal Medicine, H. Main Pollard Collegiate Profesor and (Chit Dison of Gastroenterology: Depatinent of Internal Medicine Univer sit of Michigan Medical Center Ann Atbor (271, 277],‘UsastD, Parasia, sans, xn Medical Epidemiologist, Respiratory and Enteric Virus Branch, Centers for este Control and Prevention, Aanta (171, Jamas Pusosss, wo Asociate Profewor of Medicine and of Microbiology, Datouth Medial Schook Saf Physician, Iniecons eases Section, artnoudh Hitchcock Me- Aa Center, Lebanon (111, Simevskesc R. Para, MD Asoxiate Profesor af Medicine, Deputy Chsicman, Deparanent of Sarcoma Meieal Oncology, Laer of Texas, MD Anderson Cancer Cente, Houston 14 G. Ausxasorn Parreson, Mo Joseph C. Bancroft Profesor of Surgery, Department of Surgery, Dison of Cardiothoracic Surgeey, Washington Univers School of Mein, Se Lens (es3] GGustar PacwoaRryen, 0 Profesor of Medicine, Lig Maxim Universiy of Munich, Durval, ‘Germany (292), MicHAEL C, Pas sm, rice Profesor of Inernal Medicine, Diector, Division of Hematology Oncology, Nollie B Smith Chir of Oncology, University f Misouri Elis chet Cancer (Cenc, Counts [9 CCuameycr J. Peres, wo Jon Seay Distinguished Universiy Chair in Topical and Emerging Virology Directo: for Biodefense, Center for Bindcfense md Emerging Infectious Die ses, Unies of Texas Medial Branch in Galeton, Gales [180 I] Bur A. Pinson, Sir John and Lady Eaton Profesor ae Chai, Departient of Medicine, Univer ‘of Toronto, Toronto, Ontario, Canada (245, 247) ‘of Medicine, Bowon [105] Dasiet K. Ponotsiy, 0 Malineleod: Professor of Medicine, Harvard Medical School: Chie, Garon ‘erlogy, Massachuseuts General Hospi, Boon (29,290) ‘Ronuo E.Pous, Pharm. D. Profesor of Pharmacy and Medicine, Chair, Deparment of Phariicy, Schoo of Pharmacy, Virginia Commonwealth Universi Richmond (118) ‘Marre Pottack, Mb Profesor of Medicine, Uniformed Services Universi: akaré Hebert Schoo} ‘of Mevicine: Atending Sal Pian, Internal Medicine and Infectious Des ses National Nual Medial Center, Betheda [138] Ric J, Potssca, > Ingroctor of Tropical Public Heath, Department of Immunology nd. Ine tious Diseases, Harvard School af Pile Healt, Bosom [379] Jou T Por, Je, wo Jecson Disingtished Profesor f Clinical Medicine, Harvard Medical Shoo, Boston (882) [Lava W, Powe, 3, 0 Profesor of Medicine, The Unkersty of Queendand and The Reval Bribe an Women's Hospital, Besbase, Queensland, Ausals [386] AIM C. Powens, Ruth KC Scoville Professor of Medicine, Division of Diabetes, Endoctinolo- (9. and Meabolism, Vanderbilt Unversiy Medial Cener; Cie, Diabetes and Endocrinology Section, VA Tenaesee Valley Heakhcare Siem, Nashvile be Dusit. S. Pears, wo Aint Profewor of Medicine, Tuts University Schoo of Medicine: Medical, Director of Liver Transplantation, New England Medial Centr, Bowor (38, ax) Disa Pex, > Asssant Profesor of Medicine, Boston University Schoo of Medicine; Stall Physician, Boo Veterans Afsiry Medical Center, West Roxbury [33] Daxwny J. Paocxor, a, m0 Director of Center for Gene Therapy and Profesor of Biochemistry, Tulane Health Sciences Gener, New Ofeas [82] ‘StascayB, PRusnin, Director Invite for Neurodegencrnive Diseases; Profesor, Meparaments of Neurology Biochemistry and Biopsies, Univers of California San Francie, ‘San Francie [82 ste J. Rane, o> Ascot Proesr, Deparinent of Medicine, Universi of Renan School ‘Medicine, Pilea (895), Seog Ross 0 Assistant Profesor of Medzne, Secon of Infectious Diseases, Boon Univer si Schoo of Medicine and Boston Medial Center, Boston [128] Doe Rows, wo Profesor of Medcine, Unité des Riketses, Schoo of Meine, Unies of Aux Maree, Manse, France [158] Na HRs, 0 Professir of Neurology, Universi of California San Francieo, San Franco iis) ‘Matto ©. Rancazone, Directo, Stop TB Department, Weld Heath Organization, Genera. Skier Jind [150], SuHow L Reso, sw Profesor of Pathology and Medicine, Director, Microbiology an Virology La oratories, Universi of Calforma Medical Center, San Diego [194] AxrowioJ. Recoxsro, 0 Profesor of Medicine: Head, Dison of Rheumatology: Cooper Univer Me- dca Center, Robert Wood Johnson Medial Scho at Camden, Camden (S13) Rucaw C REGAN, Md Profesor of Medicine, Microbiology ad Immunology: Head, Infect Disee ss Unit, Senior Asoriate Dean for Clinical Research, Universi of Rochester, School of Medicine and Dents, Rochester [10] (Cano M, Rave, 0 Asistant Profewor of Medicine Jefferson Medal Collegeof Thomas Jefeson ‘Unies Philadelphia (987 Jory J. Rau, no ‘Asoc Profesor of Meine, Harvard Medical Schoo: Clink Dieetor, Pak ‘monary and Cite Care Medicine. Brigham and Women's Hoya, Boson Be] Jous T: Reva, wo, race Profesor and Chai, Department of Obsetrcs and Gmecolgy,Pennshania Sate University College of Mesicine: Obsetrcansynecologist Ihe, The Milton 8: Hershey Medical Cente, Hershey [6] Naw M, Rese, x0 Profesor of Medicine, Univers of Pinsbungh Schon of Meine: Chet. Di son of Geiate Medicine, Unnersy of Pitsurgh Insite on Aging, Pte burgh i Vicror I Revs, Profesior of Pacha: Unersty of California San Fancnco: Medel Director, Langley Porte Hospital, Sen Francisco (971). Fonoiadt vos Revs Profesor of Medicine, Chef Infectious Dhesses and Inernationa Health, ‘Dartmouth Medical School. Lebaron (152) PeraeA. Rice, Mo Profesor of Medicine and Chie, Section of Infectious ikeass, Boston Univer sity Meal Center, Boon (128) Sruaer Ric, a Profeorof Medicine, Rush Caversiy Media, Chicago (220) Gary's RieweNs0%, wo Asistanc Profesor of Pachistry, Case Western Reserve University Cleveland, Senior Research Scents, Shep Disorders and Research Center, Henry Ford Hospital, Detroit (24) Gan L. Romsers0%, a0 Profesor of Meine and Neurology, Northwest aives Finbery Schoo ‘of Medicine, Chicago [319] Das M Ropes, > Profesor of Medicine and Pharmacology Chic, Dison of linia Pharmaco- logy, Vanderbilt Unieriy School of Medicine, Nashville (3] Js A, Rowano, J. 2D ‘Commander, US Army Medial Research laste of Chemical Defense, Mare lane (206) Kugry L. Roos, Mb Jolin and Nancy Neon Profesor of Neurology: Indiana University School of Medicine, Indianapolis (36) ALLAN H. Rovren, wo Profesor and Chatman of Nevo Tus Unersy School of Medicine; (hick, Department of Neurology St. Eizabeth’s Medial Center, Boson (357, 336,387], oct N. Rosexnene, ade Distinguished Charan Profesor f Neurology Universy of Texas South ‘western Medal Center at Dalia Axending Neurologist, Parkland Memorial Hospital and ZaleLipsy Uniesy Hospi, Dallas [352] -Myma R ROSENTEL, MD, Pad Asocinte Profesor of Neurology: Department of Neurology. University of Pennyhanin,Pilsdelphis (87) ‘Wn Rost, wo Florence Reynaud McAlister Profewor of Medicine and Medial Research, De partment of Medicine, Dake University Medical Schoo, Durham (83) Mics. A. RUBS, PD Asan Prof, Internal Meine, Ddson of Infetions Diseases, Dison ‘of Clinical Epidemiology, Sl Lake City [27] Rowuer M. Ress Mn ‘roesor, Freda Schoo of Nston Science and Poy Director a Seen ‘Jean Mayer USDA Human Nusrion Center on Aging at Tul, Boston (6), ‘TrowAs A. RUSSO, MD, Asinan Profesor of Medicine, Dison of Infectious Diseases, Deparunent of Medicine, Sate Unters of New York at Buffalo; Veterans Mfrs Medial Cen ter Bll (154,147, ‘Sromuex M, Sacar, 0 Profesor of Neurology, Coe Western Reserve School of Meine; Diertor of ‘Neuro-Oncology leland Cancer Caster, University Hospital of Cleland, Cle veland (358) Manus A. Swe, x0 Profesor of Medicine, University of Utah School of Medicine; President, Aca demic Alanee for AIDS Care and Prenton in Arica Foundation, St Lake iy (71 va A. Susy MD, aD Awociate Directo for Clinical Research, Greenebaum Cancer Center, Univer: sy of Maryan, Balimore (70) Mower H. Serxct, > Amodate Brofewor of Medicine, Harvard Medical School iter, Transl tation Research Cente Brighaes and Women's Hospital and Children's Hosp ‘2 Bosom (288) How 1 Sean, wv Dayne Clloay Chain Urologe Oncology Antending Pisin and Chi, CGeritourinary Oncology Serie, Department of Medicine, Memorial Star= eteing Cancer Center Profeor of Medicine, Weil Medical Cllege of Cor nel Univers, New York [80 81] Haan W. ScamoDEs, J MD, PD Profesor of Meine ad Microbiology, Univers of Alabama at Bimingham, Birmingham (237) Axe Sev, wo ‘hic, Respiratory Diseases Beach, National Cemer for Infectious Disease. (Cenversfr Disease Control an Prevention, Alana (123) Mate A. Somveatt, wD Profesor of Prychinty, Universiy of Callorna, San Dirgo; Director, Aco Research Centr ites, Aleoho and Drug Treatment Program, Veterans AF ‘aire San Diego Healdneate Sem, an Diego [372,378 Sruser Sener, m0 Profesor of Genetics and Oncology, Cente for Human Genetic Tarai lean (571 Dov $. Ssca, PAD Profesor f Pachiatry, Unites of Clfornia San Diego, La Jolla [373] Jou L Sars, xo “Anois Profesor of Mein, Hareard Medical Sehook Phin, Brigham ‘nd Women's Hespal. Boson (270) ANDREW PS MD Profesor of Medien Hart! Medical Schoo; Phin, Brigham and Wor ‘en's Hospital, Boston [226] Sra D. SHAM, NO Patker B. Fanci Profesor of Medicine, Harvard Medial School and Brigham and Women's Hoyt, Boston [382,990,251] STE I, SHAN, NO Asocate Profeor, Unversity of Texas MD. Anderson Cancer Center, Adj Asoviate Profesor, Baslor College of Medicine, Houston [390 Wann Sten, Johnson and Johnson Disinguisbed Profesor of Surgery, Emerius, Harvard ‘Meal School Bossom (1,280, 281] [Epioy K.SUNERNA, MD, PD Assitant Profesor of Medicine, Hansard Medical School Brigham and Wor en's Hospital, Boston (242) Gaur 6. Soxcen, 0 Asian Frofeor of Medicine, Washington Unters Sehoo of Mein: Ae ‘ocate Direc, Transplant Nephrology, Barnes Jewish Hospital, Sc Lous [41], Aye K Svea, 0 Asis Profesor of Medicine, Harard Medical School Director of Clic ‘Nephrology, Brigham and Women’s Hospital Boston (262) Joon Dow Swe, mo Profesor Enerns, Boston University Seool of Medicine; Seietii Review Ad ‘ninistetor, Navona Tnstiaes of Heath, Bethea (310)Kant Skonvcx, x0 Amie Chtick Profesor of Medicine, Bruce Rappaport Faculy of Medicine, Technionzel Insitute of Technology: Dtecor, Department af Nephrology and Molecular Medicine, Rambam Metal Cener, Hai, Israel (261) Gama W. SuTANA, uO Avoriate Profesor of Medicine, Harvard Medical chook Division of General Medicine and Primary Cate Beth Irae Dracones Medial Center Boson [7] Permex M, SLs, aD Director, Immunodagnonties Laboratory, Department of Pathology, Mavs seus General Hospi, Asintant Prono, Harvard Medial Seo, Benton tapindices) Wane S. Siar, > Asodate Profesor of Neurology Decor, Newoinenive Care Service, Uni. ‘ers of California San Frandao, San Franco (349) Micnass C. Sri, (Chie or nmunologc Diseases Section, NIAID, NIH, Bethesda [06] Jas B. Now, Je, > Profesor Emeritus, Deparment of Otorhinolaryngol, Univesity of Peni ‘ania former Director, National Insite on Dealnes ahd Other Communic thom Disorders, National Insite of Health, Bethexda (26) “Anti J: Sone, 0 Profesor of Dermatology Harvard Medical School Ascate Chie of Dermat tology, Masachusets General Hospital, Boston (73) Mique. F Soman, 0 Robert L. Grissom Professor of Medicine: Chit, Section of Castoemterology an! Hepatology, and Medical Decor Liver Trsneplanation, Unter of Ne brad Medial Centr, Omaha [288] Pera SPER, uD, AD Profesor of Internal Medicine, Dison of Infectious Dist, Tropical Medi fine and AIDS, Department of Internal Medicine, Academic Medal Gentes, Unive of Amsterdam, Arserda, The Netherlands [13] Pease E Sr, 0 Edvard H. Kass Pofeior of Medicine, Harvard Medial School: Co-Diector, (Channing Laboratory, Bigham and Women's Hospi, Prose of Eire ‘mental Science, Harvard Seool of Pble Health, Beso [238] ANDeEW SPIN, Profesor of Tropical Public Health, Harvard School of Public Health, Boxon ism) Jonas L. Sigs > Profesr of Medicine and Oncology, Jos Hopkins Univers School of Med ine, Baliore (95) aur E Stas, 0 Profesor of Medicine and Head, Dito of Allergy and Infectious Diseases, Univers of Washington School of Neicne, Seal (160,209) Au C. Sree, x Profewor of Medicine, Harvard Medical Sch Mavschutets General Hospital, Boston [157] Director of Rheumatology, Dow S, Sram, 0 Dire: Dison of infections Diseases, Emory Universi Hospi Spon W. Slwarumanin Profesor and Exeeutve Vice Chair Department of Medicine, ory Universi School of Medicine, ana [127] Rost S. Stem, Mo (Gar). Herzog Profesor of Dermatology, Harvar Meal, Boon (50) Devats L. Stevens, MD Profesor of Medicine, University of Washington School of Medicine, Sea: (Che: Infectious Diseases. VA Medial Centr, Boise (110) ‘ucuaKD M. StoNE, wo ‘linia iret, Adult Lenkemia Program, Dana Farber Cancer Insite/ Brig. hm and Women’s Hospital Awocite Profesor of Metkine, Harvard Media School Boston (85) Srupmey . STRAUS, NO Senior Inetignnn,Laborstory of Clinical Investigation, National Insite of Allergy and Infectious Diseases Director, National Cece for Complementary tnd Ahernative Medicine, National Insite of Health, Bethesda (10, $70] Monroy N. Snaer2, 0 Profesor, Deparment of Medicine. Harvard Meda Schoo Chit Bmerius Infecious Disease, Chie, ames Jackson Firm Medial Services, Masaicsens General Hospi, Boston 181), A joa Tap, xo ‘Thomas]- Wavon, J, Profesor, Profesor of Meine and Pediatric Mayo Clr bie College of Medicine Chair (Ener); Diviion of Cardioesclar Diseases snd Internal Medicine; Constant, Seton of Pedic Cardiology, Mayo Ck ie, Minnesota (211), Jom D. Tatx00, 00 Proesar of Imernal Medicine, and Wiliam M. and Gatha Burnet Profesor for Arthris Research, Universi of Teas Sohwestern Medical Center, Dalls (296, 305) Scorr J Taste, > (Chick Medical Oticer,AERAS Global TB Vacine Foundation, Bethea [314] Zee A. Toca, 0 [Avociate Profewor, Department of Radiation Oncology. Unnersiy of Penns ‘aia Medial Center Philadelphia (217) Lucy Sreaar Tove, 0 Profesor of Medicine Infecou Diseases and Geographic Medicine), Pre sor of Merobialgy, Inemunology and Pathology, Sanford University School of Medicine, Sanford [14], Maes Tors 0 Associate Profesor of Medicine, le UnitersiySehool of Medicine: Asant Directo Gastrointestinal Procedure Center, Yale New Haven Hospital, New Hie en [23] Panu P Toss, wo Profesor of Medicine and Directo, Dison of Gastroenterology, Hepatsogy and Nation; Aasodate Chairman fr Clinical Ais, Department of Medice ‘ne, University of Florida, Gane [295,298] Jeomesy M. Tr, > President and Scenic Direc, Senior Investigator, Molecular Diagnoses nd Target Validation Divson, TGen, Phoenx (68) Eunext P. THeL0CK, wo Rosemary and I. Jerome Fanee Profesar of Pulmonary Medicine, Wathingzon ‘Uneniy School of Medicine; Medial Diretor, Lung Teanspamation Pro ‘gram, Barnesfewish Hosp, S. oul 248) ‘Kener L The, euler Levin Family Profesor of Newology: Profesor of Medicine, Microb. Jogy and tmunclogs University of Colorado Health Seiences Center; Chie, ‘Neurology Service, Denver VA Medal Cen, Denver [360] uxt Vocus, Mo Profesor of Oncology and Pabolog, Howard Hughes Investigator, The Sie Kimmel Comprehensive Cancer Center, The Johns Hopkins Universi Schoat of Medicine, Balimore (68) ‘Byimsr? Vous, wo Diecioe Seton of Hematology/Oncoogy John F.Ultmann Profesor of Me- icine and Radiation Oncology University of Chieago, Chicago (74) “Towns J. Vous, wo Asistant Prfesc of Clinical Meine, Unrest of Chicago Pritzker School of Medicine, Chicago [384]MarmK, WaLDOR, MD, AD Awociate Profesor of Medicine and Microbiology, Tuts UnhersiySehool of Medicine, Boson (140) Davo H. Wan, > Profesor and Chairman, Deparment of Paolo: Director, WHO Calabor ‘ng Center fr Tropical Deas, Univers of Texas Medical Branch, Gales vo (158,29), Rican J. Wauac, Je, 0 Chairman, Deparment of Microbiology, Jon Chapman Profesorship in Me cobialogy, Profesor of Medicine, Univers of Texas Health Center, Ter ie) B.Toiory Was > uae Profesor of Pichia, College of Physicians and Surgeons, Columbia ‘Universi Director Esting Dorder Research Unit, New York State Pychiatic Taste, New York (68) Peron D. Watzm, wo Awociate Chie of Sal for Research, Cneinnat VA Medical Cente, Profesor ‘of Medicine, Livers of Cincinnati, Gncnnat [191] Fremenick C.8, Wasty MO Avoca Profewor of Medicine, Harvard Medical Schoo: Medic] Direc, lk nical Virology Laboratory, Brigham and Women's Hospital, Boston (11,167) Cane. WasHNTON, J MD sistant Profesor of Dernaology Emory Unineriy School of Medein; Di rector, Mohs Surgery Unt The Emory lnc, Alana [73] ANTHONY P. WHETMAS, MD, DS Profewr of Medicine and Dean, University of Shefeld Medical School: Con- sullnt Physician, Northern General Hospital, Sheffield UK [320] ‘Sreves E, Wansencan, wo Profesor of Metvine, Harvard Medical Sehoo: Senior Vee Present. Medial Knowledge and Easton Dison, American Cllge of Pyicians Philadelp- in (90, 23585, 290) Ronee A. WESTER, MD Profesor of Medicine, Rosh Medial College; Cha Tfetious Diseases, Cook ‘County Hospital Chie Operating Office, The CORE Cente, Chicago [116] ‘Peron F. Wat, om, r8cP Profesor of Medicine, Harvard Medical School CoC Infectious Diseases Divison: Chie, Alergy and Tffamnation Diviiom; Senior Vie Chair of Re- search, Depatnent of Medicine, Beh el Deaconess Medial Center, Bexton [o8202, 204) McA R, Wess 9 Profesor of Pediatrics and Medicine (Microbiology and Molecular Genetic), Harvard Meal School Chie, Don of Infectious Diseases, Children's Hos. pita, Bosom (121) Lee M. Wer, wo Asda Profesor of Medicine and Microbiology, Boston Univers Sehool of Medi, Boson [127] Mow Werzise 0 Aocite Profesor of Medicine, Roel Park Cancer Insite, Bal (96) A. Cuvton Wore, Je x0 Profesor, Infeous Dacases Section, Deparment of Medicine, BalorCalege of Medicine, Houston [205] NucwousJ- We, MD, OS Profesor of Tropical Medicine, Mahidol Universi, Bangkok, Thailand and (Oxford Unies, Oxford, UK 195] ‘cian J- War, mo Loeb Eminent Scolar in Perc: Profesor of Pediaics, Microbiology, Me= ‘eine, and Newosurgery Unies of Alabama a Biringhan, Birmingham iy Gonoow H Wna208, no Profesor of Meine, Harvard Medical School Chief, Cardiovascular Endocr logy Seton, Brigham and Women's Hospital, Boson (230, $1) ons W. Wovxe, uD, ad Avixtant Profesor of Pichia, Hareard Medial School Medial Directs, ‘Slep Health Center, Brigham and Women's Hospital, Boston 24] ‘Bavce U. WaTROUB, x0 Profesor and Ghairo€ Dermatology, Associate Dean, School of Medicine, Unk ‘ery of California San Franco, San Franco (50) ‘AUN W, Worx, Profesor of Medicine aud Anatomy and Structural Biology, Albert Einscin Cie lege of Medicine, New Yok [284], ‘Ronuxr L Worm, 00 Profesor and Chai Departnent of Interal Medicine, University af OXhora Collegeof Medicine, Tal [55] oso Wines, an, as, Profesor of Medicine, Wayne Sate Uaversiy; Attending Physician, Detot Me ‘ial Center Deol (221) Row B. Yancrs a Profesor and Char, Deparment of Dermatology Medical Collegeof Wiscon st, Svan (46,19) Jaaas B, Youre, ww Profesor of Medixne, Executive Avoca Deun for Faculy Airs, Norhes tern Unhersiy Feinberg School of Medicine, Chicago (322) NewS. Yous, Mo Chie, lematlogy Branch, National Heart, Lng and Blood Isnt, National Tesiites of Healt, Bethesda [94] Rosaxr C. Yous, wo resent, Fox Chane Cancer Center, Philadelphia 88] Au S.L. Yo, mn, nose ‘Asistam Profemor of Medicine, Universit of Southern Cafornia Keck Stoo of Medicine, Lon Angeles [26] ‘Vector LY Mb Profesor of Meine, Universi of Psburgh: Chie, Infectious Diese Sec tion, VA Meal Center, Pitsburg (132) Dorr F Zag MD [Asocite Clinical Profs of Medicine, Harvard Medal School Seuior Ph ‘icin, Beth bral Deaconess Medica Cente, Boston (112) Pere -ZiMeTmAL, [Asin Profesor of Medicine, Harvard Medal School Beh el Deaconess Medial Center, Boston [213,214]Hace mis de 50 aos salié a la luz la primera edicion de Priniins de tmnicna semua de Harrison. Con el paso de los decenios el texto ev0~ Tuciondy recog los progress ininterrumpicos en el campo de lame- dicina interna y pudo satfacer la base de informacion cada vez mas amplia que exigian los estdiantes los cinicos en su prtica. Los lec- tores de esta decimosexta edicin del texto se pereataran, incluso a tes de abrirl, de que consitaye un punto de transiién en la historia de la obra, La neta cubiertaconsttuye el signo mis obvio de su nue- ‘Al estructura y resiar la nueva versin, los eitoes se comprome: sieron a que el texto tuvera la maxima utilidad posible para estudin- tes y médicos que afrontan ls exigencias de la medicina actual. La proliferacon de la medicina factual (hasida en evidencias), la impo tancia de aplcarerteros econémicos a la astencia sanitaiay la ex- plesidn informatica en reas fundamentales, como los aspectos ‘genéticos de la enfermedad, son apenas res de los muchos factores que toman diferentes las exigencias actues, rexpecto de las que afrontaban los médicos hace apenas dezaios. La cubieria conserva los ‘lementos hisicos de la obra edsca, pero el comenido conserva losas- pectos esencales cle uilidad e importanciaelinica. Sin embargo, las ‘mxlficaciones en su formato y contenido permiten ala nueraedicion del texto satisfacer las necesidades cambiantes de sus lectores. 1a 16 edicin de esa obra tiene un formato a color que facta la conailta pda y que ha permitido inclu centos de iustraciones de gran calidad! que no tenian las ediciones prevas.Esperamos asi sts cera comodidad del ecto, alcolocar ilutraciones en color insertadas en los apitulosy no de manera separada como anteriormente se hizo, Plantear los datos de ciencias bisicas es un elemento indispensable para comprender los temas de biologi y fsiopatnogt, pero esta obra se btienta de manera directa y extensa mas en lo agpectos eruciales de la préctca clinica, Puntos de énfassincluyen el estado del pacente, siagntico diferencia, ls opeiones terapéuticasactualesyla preven cin de enfermedades. Temas biscos como el sistema inmunitario y La infeccén por VIH/SIDA se exponen en capitals que son por sf mis- tos minitextos. Nuevas secciones ineluyen datos de problemas form- dables que alronta la medicina de cuidados intensivos la amenaza del bioterorisno, Capiulosigualmente nuevos bordan temascliniens de ‘mixima importancia como la deteccidn sstemitica de enfermedades, cl tratamiento en [a etapa perimenopansica, la reposicin hormonal y Jos cuidados terminales. Pricticamente todos los capinulos han sido reesritos 7 46 son totalmente nuewos 0 tienen nuevos autres Seialaremos algunos puntos destacables de as modificaciones que hardin de este texto, en opinion nuestra, una herramienta poderos, tanto para el estudiamte que necesita conocimientos bisicosy expertos ‘en medicina interna, como para el médico agobiado que necesita un extraco claro, conciso, y equilibrado de la mejor informacion para bar sat las decisiones que toma dia a dia Tapare |, “Intoduecion ala medicina clinica", contiene un nuevo capitulo que incluye informacidn practca sobre lis cnicas de detee: ‘dn sstemitca que debe considerar todo internistaen sos rareas di ‘las de conservacion dela salud, El capitulo expone los principios ylas sirectrces usadas para la deteecién sistemstca de enfermedades co- srientes como el cancer, la hipertenson, los trstornos de lipids la ‘osteoporosis, Owos capituos nuevos aportan uma estategia pragmdc- ‘ca para la evaluacin médica de pacientes a quienes corto plazo se les practicaré un procedimiento quinirgico, Ane la proliferacidn dela co- friente“astencalista’ (apoyo a personas desahuciadasy sus familia: res) y la mayor conciencia. de problemas dlgidos de orden fico, psiquico, social yexistencial que rodean a la atencién de enfermos ter ‘inales,lemos incloido un capitulo nuevo de este tema complejo con datos de divers tipo y oriemacin para los médicos que atienden mo- ribundos ya sus parientes. Hl capitulo de la salud dela mujer fue re sado ens totalida y es una vision panorimica de la forma de abordar problemas que afectan preferentemente ala muje ‘La parte Il, “Sintomas principales y cuadro inicial de las enferme: aces es una introduccion imtegral de la medicina clinica yuna gia prictca pare a atenciém de pacientes com tales manifestaciones. Cada Seccin se ocupa de un grupo particular de enfermedades, y explora Jos conceptos de fsiopatologia ¥ dingndsico diferencia por conside raren la atencién de quienes prescntan estos euacros clnicos nici Jes, Se hace tna revisin de los principales sintomas y se intenta relacionarlos con enfermedades especifiss, y también se plantea ut resumen de las estrategis clinicas para quienes los presentan origina ‘mente, Cada eapito ha sido acnualizado y wes de ellos tienen nuevos autores. E.que expone la disunciin sexual se ocupa de tastornos de ‘raanes y mujeres. Ante los progresosripidos que se han sucedido en el campo de kt gentica humana en os ttimos alos, se actualiz6 por completo la par- te ll, “La genética y las enfermedades". El material incluido en esta ceicidn se centra netamente a a prietica clinica en que interviene ‘da vee mis la informacin sobre genética. El nuevo capitulo sobre ¢ toblastos y transferencia géniea ent medicina clinica expone wn tema ‘oportuno y conttovertido, define ls pos de citoblastos y destaca ss posibles aplicaciones clinicas, a parte IV, “NatrciGn’,seiala consideraciones nuticionates vin culadas com la medicina einia, Ente los aspectos ms relevantes esti Ja evaluacion nutricional yalimentaria, ls necesidades mutricionales, a smalnuticin proteinicoralrica, trasornos de ls slimentacién, obes: dad y terapia enteral y parenteral El tema central de esta obra seguir siendo la ncusion de enferme dades de Gxganos y sistemas, que se exponen en la secciones V a XVI. Ein ells e hacen deseripcianes breves de Tos aspectos fisiopatoligicos de enfermedades que afecta los dnganos sistemas principales yas in feeciones, con énfadis-en sus manifestaciones clinicas, métodos diag nticos,diagndstca diferencialyestrategias directrices terapéutics Ta parte V, “Oncologia y hematologia,incluye custo capitulos ex critos por nuevos antores. En la atualidad es posible que una propor cdn cada ver mayor de cancerosos curen de su enfermedad. Es ‘importante identifica las consecuenciastrdias lo mas tempranamen- te posible dentro del curso naural, para levar a nivel dptimo los esl tados. El capitulo que trata de las consecuenciastardias del cncer y su ‘Matamiento er iil para que los médicos que vigilan a esos pacientes sepan To que deben averiguar adem de a recidiva de las neoplasias Se destacan los progresos en el tratamiento de muchos cinceres, por ‘gjemplo, la trascendencia extrordinaria del meslato de imatinib en la Jencemia micloide erénica y tmores gastrointestinales de célula del ‘trom ai como la uid del rituximab en la terapia del infoma y Jas enfermedades ttoinmunitarias, Ei Glasein reacts de nuevo todo capitulo sobre los principios de la radioterapa yes coautor del capi {ule sobre bioterrorismo por radiacién en la parce VII (véase adelante). La seccin ce hematologiaincluye la nueva clasifcacion de neoplasos linfoides y mieloides de Ia Organizacién Muna de la Sad, Una de Jas dreas de expansion més ripida en medicina es la obtencin de sus tancias nuevas que iterfieren en la eoagulacién de I sangre. El autor ‘nuevo, expert en extaespecialidad,expone las verapias a hase dean coagulantes ibrinoliticosyantiplaquetaros, revs los productos de re dente aparicin y sus indicaciones. La parte VI, “Enfermedades infeccious™ resume la informacion mis recente sobre ls aspectos de patologia, genética y epidemiolog _yse entra concretamente en la necesidaes de los clinicos que eben. Siagnosticar y tatar con certdumbre infeccones, contra el rel) y ls Timitantes econémicas. En particular, la abundancia de nuevas ilusta oncones en color permite contar com informacién accesible para que los ‘lnicossuperen estos problemas. Se sefialan recomendaciones espec ficas de regimenesterapéuticos, que incluyen el firmaco mis indicat, sus doss, duracion de la terapiay alternatvas. Los autores presentan las tendenciasactualesrespecto de la resistencia. aantiicrobianos y la ‘exponen en el marco del impacto que tiene en la selecidn de terape- ticas Un capitulo nuevo aporia informacion bisia sobre el watamien to de problemas clinicos complejos que han surgido por las enfermedades eawsadas por Chtndium dificil, nel la colitis sexe domembranosa. Autores nuevos se ocupan de los progresos recientes fen cl urtamienta de enfermedades causias por estaflococos y mico- bacterias no tuberculosas, gastroemeriis virca y brueeloss, El estu- Pend capitulo escrte por Raphael Dolin sobre infecciones communes {de vias espiratonas por virus, e ha ampliado paraincluir los datos mis completo sobre el sindrome respiratorio agudo y grave (SARS). Fl ca- pitulo sobre infeeciin por VIH y SIDA, eserito por Anthomy'S. Fauci y HL. Gifford Lane, incorporado en una seccin separada que ineluve tuna revisim de Tos retrovirus humanos, fue revsado y acmalizada del todo, y se concedié gran importancia alas esrateyias erapéutica. EL ‘material en cuestién ha sido consderado como un eisico en fa mate- fia; so enfoque pragmatico yclinico en eombinacén con su abordie ‘ncegralyanaltico dela patogenia de la enfermedad por VIH, ha per ‘mide usarlo come fa nica referencia completa sobre ese tema en las escuelas de medics En ais recientes los médicos han quedado en la linea del frente en ataques bioterrorstas en todo ol mundo, Desde los sncesos del 1 de septiembre de 2001 en Estados Unidos los envios por correo de halo del carbunco (intrax), han poliferado preparativos para affon= lar nuevas psibildades de atagues. La pate VI, “Bioterrorimo y me dicina clinica’, consiste en material nuevo eaborado por autoridades fen tres areas del bioterrorisme: microbiano, por sustancias quimicas y por radiacin. Revisados por el Dr. Fauci tales capitals son estruct- ‘dos en forma sucintay comprenden esquemas como cuadrosy algo- "tmos de fil lectara; su objetivo es destacar los eonocimientos de patogena, el diagnésio, el tatamientoy el pronéstico de Tas enfer- Imedades en cuestén, La parte VIL “Enfermedades del apurato cardiovascular” ha sido ‘oorinada una vee més por una eminencia en ee eampo, el Dr. Euge- ‘ne Braunwald, Un capitulo nuevo se ocupa de los temas importantes como angina inesabe e infarto del miocardio sin elevaién del seg mento ST: se han revisado tres eapitulos mas que tienen mucvos aute- res para que reflejen lay tendencias y estrategias mis nuevas en el tratamiento. Comprenden la interveneién coronaria pereutinea pe- maria para el infarto con elevacin del segmento ST y también nuevos armacosy dispositivos para tratar la insficieneia cardiac, Se han hecho enormesadelantos en el campo del tasplante de pul smones para enfermos escogidos con ataque terminal e irreversible de los pulmones yvaulopatis. La parte IX, “Enfermedades del aparato respiratorio’, inclaye un capitulo que ha sido escrito por un ator aue- ‘vo que secentr6 en laseleccin de pacientes sometides a dicho proce- dimiento, Autores también nuevos se han ocupado del amplio tema de Ja neurnonfay el abseeso pulmonar, y han aportado su perspectiva c= nica para que el lector capte los aspeets fundamentals del diagnds- coyel tratamiento dela enfermedad nosocomial y la adquirida en la comunidad. Ls progresos en Ia presacin de servicios las presiones que sur- ‘gen con la restrccidn de costs, no han sido obstculo para que hoy en dia un poreentaje eada ver mavor de camas de hospital estén destinn- «dasa las unidades de euidad intensvo, La parte X, “Atencidn de en- {ermos en estado critica”, es una nueva soceién que se ocupa de todo Joreferente ala asistencia Sptima ental situacion de importancia cada ver mayor. La parte mencionada, que incorpora nuevos capitals 9 corientaciones noredosas sobre el tema cubiertas en ediciones previas, inclue tres aspectos principale: cuidados intensives de ipo respirato- rio, choque y pao eatdiacoy cuidados eriicos neurolgicos. El aspec- to fundamental de esta parte de la 16* edicin son las eategias que se siguen con el paciente los principos fundamentales en que se bash la medicina intensva La parte XI, “Trasornos del fin ylas vias urinaras,inclue con tribuciones de autores nuevos ¥, como en ediciones anteriores, hace luna revision minuciosa de enfermedades de vias urinarias que son pat= te de la medicina interna, La parte XI, “Enfermedades de ls vias gastrointestinaes,inclaye un capitulo sobre poliserostis familar recurrente (fibre mediterri- nea familia). Un nuevo autor reestructuré por completo el capitulo sobre el estudio del enfermo de vias gastrointestinaes,y también lo hizo con el eapitulo de dvertculossyvasculopatas de Yo inestinos. Las capiilos de las eategoias de hepatitis ire, Facron reid ¥ 3 ‘walizads ampliamente para que iaclayeran los progress mis notables El primer capitolo de la parte XI, “Trastornos del sistema inmu- ‘ita, el tefido conectio y la articulaciones, incluye una introduc. ‘idm sobre el sistema inmunitario que se ha wielo elisa en este terreno yque suele ustrse como texto de inmunologfa en los cursos de ‘posgrado y otras reas dela medicina, Combina a descripeiin yet ans Tiss minucioso de los principis dela inmunologia de seres humanos ¥'laaplicaci6n de los mismos a enfermedades elincas. Su descripci6n de la Felacion entre a inmunidiadinnata ya adaptatva es un mode= lode conocimiento de las complejdades del sistema inmunitario del hombre: Los autres, una ver mas, revisaron detenidamente el capi- tl para actualizarlo de modo que concordara coa los progresosre- cientes en el campo de la inmunologia cisicay clinica. En la sec de his enfermedides medidas por meeanismos inmunitaros, se in- ‘luyeron en un solo capitulo ls espondiloartropatias, donde ve des tacan de manera clara ¢ integral las semejanzas y diferencias de tales ‘enfermedades, Se incuyen asimisno los progresos ms sobresalien- tesenlaterapiainmunomoduladora en reumatologia yen los ca los muy completos sobre artis reumaroide y lupus eritematoxo diseminado, Se ha elaborado un nuevo eapiculo sobre fibromialgia, artrtis que acompatia a enfermedades sstemieas y otras enfermeds des de ene tipo, Ta pane XIV, "Endocrinologia y metabolismo”,abarca seis capttu- Jos com autores nuevos yun capitulo muy oportune sobre la transcién en la perimenopausiay la reposicibn hormonal. La elaboracion de ‘este eapitulo coincidi com la publicacion de los resultados de la Wo- ‘men's Health Initiative que de manera inesperada demos el inere- mento del riesgo de enfermedades cardiovasculares en mujeres que recbieron estrogenos. Los autores risa las publicaciones de dicho ‘apo y aportan algoriamos pricticas para watar a pacientes durante ‘ea transiciin. Los nuevos partcipantes del capitulo sobre wastarnos de la diferenciacidn sexual destacan conocimientos nuevos obtenidos ‘de las aes genéticas dela determinacién sexual. EI nev capitalo de rmetabolismo de hvesos y minerales constitve una base estupenda pars ‘conocer la fsiopatologiay tratamiento de diversas osteopatias metab Has, La sersin eserita por un autor nuevo del capitulo sobre alters cones del metabolismo de lipoproteinas centra la atenciOn mis derallada ala clasificacion,diagnstico y tratamiento de trastornos de] imetabolsmo de colesteroly wiglieridos y destaca el uso de estatinas para disminuir el riego cardiovascular. El capitulo nuevo sabre enfer- mera de Wilson se ccupa de las recomendaciones terapéurieas tral antente modificadas contra tal eatidad a pane XY, “Trastornos neurol6gics", ha sido actuatizaa en su totalidad. Un captlo nuevo yamplio sobre la enfermedad de Ale mer y demencia similares resume los innumerables eonocimientos recientes sobre el tema, destaca los nuevos conocimientos de los me Canismos genéticos de estas enfermedades y las moléculas que las ori- sginan y también constitaye una guia clinica para diagnéstica, el ddiagnostico diferencil y los tatamientos mis nuevos. El nuevo cape tulo sobre enfermedad de Parkinson incluye los hallagos recientes ¥ cs una aportacion autorizada para el tratamiento, que incluye méto- dos operatorios Se reestructuré del todo el capitulo sobre enferme- dades cerebrovascular para que constnuyera un enfoque factualpra la terapiay prevencién de accidente cerebrovascular, que ocupa el tercer lugar como causa de muerte en el hemisferio occidental. EL capitulo actualizco sobre escleross miiiple inluye los progresos ‘nis recientes en la terapia Yun enfoque préctco para tratar las ife- rentes etapas de la enfermedad. Por dltimo, I iemtificacion de la en- cefalopatia espongiforme hovina en muchas regiones del mundo ha hecho que la cominidad médica de todo el mundo presteatencién a tas manifestaciones biolgicasyclinicas de las prionopatias; a edcion presente inchiye una rein global sobre el tema hecha por Stanley Prusiner, premio Nobel a parte XVI, “Intosicaciones,sobredosis medicamentoss y enve- rnenamientos’, ha sido reisida en detalley centrada en temas de mix ima importanciaen la medicina interna ‘Ante la exigencias que impone la educacién continua para la con ‘esi de eéula profesional y su renovacion, el énfasis que se ha dado ala cerifcacin yrevalidaién, se publica por separa la edicin rev sada del libro de Autoevaluacion y repaso con base en esa 16*edcin, El tema ha sido abordado cahalmente por el De Charles Wiener, autor ‘novel del Hospital Johns Hopkins Inclye eientos de preguntas basidas cena presente edicion ysus respucstasyexplcaciones. En euantoal Max ‘nual, qe fue pionero como complemento de la 11* edicion de Harr- son, se retrbajé como un manual clinieo de referencia ripida; et ‘Manual de medicina apareceré en seguida de est 16 ec, Expresamos nuestro agradecimiento a colegas yasociados que por ser experts en sis campos hicieron erticis constructivasybrindaron sugestiones tiles y entre ellos destacamos especialmente a Joseph Al- pert, Michael Bray, Mark D. Carlson, Daniel H. Lowenstein, Lawrence © Madolf, Thomas R. Martin, Chung Owyang, Alice Pau y Mary Wright ‘Agradecemos en particular a Kenneth y Elaine Kaye, y Lindsey Bo den el haber reunido ilustraciones de gran calidad sobre enfermeda- des infeccionss, Nuesto agradecimiento incluye también a Eileen J Scott, quien también habia aplicado su experiencia editorial en Lax seis ediciones anteriores de exta obra y a Marsha Cohen quien disei6 et ‘estoy la portada de cinco ediciones pasa. ‘Agradecemos cumplidamente la partcipacion de Paicia L. Dut fey, Gregory K. Folkers, Sarah Matero, Julie B. McCoy, ayn Otivo, Eli zabeth Robbins, Lesie Runnels, Kathryn Saxon, Marie Scurtiy Sue ‘Anne Tae en as tareas editorials. ‘Queremos destaear la labor sobresaliente de ues miembros dele ‘organizacion McGrail, Se tara de Marizpax Ramos Englis, Senior ‘Managing ator; Robert Laffer, Production Direcor,y Martin J. Won siewier, Publisher. De ellos rcibimos aliento incesane y erientacion invaluable, Materalzaron los cambios props de esta edicin y [oh céeron de manera Gptima y oportuna. Les Eprrowes