GENERIC BRAND DOSAGE INDICATION MECHANISM CONTRAINDICATIO ADVERSE NURSING

NAME NAME OF ACTION N EFFECT RESPONSIBILITIES

Citicoline Zynapse 1 gm/cap Cerebrovascular Citicoline Patients with Citicoline may  Watch out for
q12° Diseases, activates the parasympathetic exert a hypotensive
accelerates the biosynthesis of hypertonia. stimulating effects
recovery of structural action of the
consciousness phospholipids in parasympathetic  Somazine must
and overcoming the neuronal , as well as a not be
motor deficit. membrane, fleeting and administered
increases cerebral discrete along with
metabolism and hypotensor medicaments
increases the effect containing
level of various
neurotransmitters,
including
acetylcholine and
dopamine.
Citicoline has
shown
neuroprotective
effects in
situations of
hypoxia and
ischemia.
GENERIC BRAND DOSAGE INDICATION MECHANIS CONTRAINDICATIO ADVERSE NURSING
NAME NAME M OF N EFFECT RESPONSIBILITIES
ACTION

Mannitol Osmitrol, 100 cc q6° Promotion of Mannitol Pulmonary congestion Fluid and The
Resctisol diuresis increases or oedema; intracranial electrolyte cardiovascular
in the urinary output bleeding; CHF; imbalance; status of the
prevention or by metabolic oedema with acidosis patient should
treatment of inhibiting abnormal capillary (with high be carefully
the tubular fragility; anuria due to doses). evaluated
oliguric phase reabsorption of severe renal disease; Nausea, before rapidly
of water severe dehydration. vomiting, thirst; administering
acute renal and headache, mannitol since
failure electrolytes. It dizziness, sudden
before raises the convulsions, expansion of
irreversible osmotic chills, the extracellular
renal failure pressure of the fever; fluid may lead
becomes plasma tachycardia, to fulminating
established. allowing water chest congestive heart
Reduction of to be pain; blurred failure.
intracranial drawn out of vision; Shift of
pressure body urticaria and sodium-free
and brain tissues. hypotension intracellular
mass. or hypertension; fluid into the
Reduction of acute extracellular
high renal failure; compartment
intraocular skin following
pressure necrosis; mannitol
when the thrombophlebitis infusion may
pressure . lower serum
cannot be sodium
lowered by concentration
other means. and aggravate pre-
Promotion existing
of hyponatremia.
urinary
excretion of
toxic
materials.
Edema
GENERIC BRAND DOSAGE INDICATION MECHANISM OF CONTRAINDICATIO ADVERSE NURSING
NAME NAME ACTION N EFFECT RESPONSIBILITIES

Paracetamol Biogesic 500mg/tab Pyrexia of Pharmacology: Nephropathy. Paracetamol has Instruct the
unknown Paracetamol rarely patient to take
origin. Fever produces been found to with meals.
& pain analgesia by raising produce 
associated w/ the any adverse effects Have plenty of
common threshold of the in water when
childhood pain therapeutic doses taking this drug.
disorders, center in the brain and is
tonsillitis, and usually well
upper resp by obstructing tolerated by
tract impulses at the aspirin-sensitive
infections pain- patients.
post- mediating Toxicity may result
immunization chemoreceptors. froma single toxic
reactions, The dose of the
after drug produces drug or from
tonsillectomy antipyresis by an chronic
& action on the ingestion.
other hypothalamus; heat The following
conditions. dissipation is adverse
Prevention of increased reactions have been
febrile as a result of reported: Skin
convulsion. vasodilation and eruption,
Headache, increased hematological
cold, peripheral toxicity
sinusitis, blood flow. eg,
muscle thrombocytopenia
pain, arthritis Pharmacokinetics and leucopenia,
& : methemoglobinemi
toothache. Paracetamol is a
rapidly which can result in
and almost cyanosis, and on
completely long-
absorbed from the term use, renal
gastrointestinal damage
tract. can result.
Following oral
administration,
peak
plasma levels are
attained in 10 min
to 1
hr and the half-life
is
75 min to 3 hrs.
Distribution of
paracetamol to
most
body tissues and
fluids
is both rapid and
uniform.
Paracetamol is
excreted in the
urine
primarily as the
glucuronide and
smaller amounts as
the
sulfate,
mercapturate
and unchanged
drug.
Approximately
85% of
a dose of
paracetamol
is excreted in the
urine
within 24 hrs after
administration.
GENERIC BRAND DOSAGE INDICATION MECHANIS CONTRAINDICATIO ADVERSE NURSING
NAME NAME M OF N EFFECT RESPONSIBILITIES
ACTION

Nimodipine Nimotop 30mg/cap Prophylaxis Calcium Severe BP •Take apical pulse

and treatment channel lowering, GI prior to
of ischemic blocking agent disturbances, administering drug
neurological that is deterioration and hold it if pulse is
deficits due to relatively of renal below 60. notify the
cerebral selective for function, physician.
vasospasms cerebral disturbances
after arteries of heart •Establish baseline
subarachnoid compared with rhythm, data before treatment
hemorrhage arteries phlebitis, is started.BP, pulse
elsewhere in increase of and laboratory
the body. This liver enzymes. evaluations of liver
may be and kidney function.
attributed to
the drug’s high •Monitor frequently
lipid solubility for adverse drug
and specific effects, including
binding to hypotension,
cerebral tissue. peripheral edema,
tachycardia, or skin
rash.

•Monitor frequently
for dizziness or
lightheadedness in
older adult, risk of
hypotension is
increased.