4/21/2018 Chronic atrophic rhinitis - Wikipedia

Chronic atrophic rhinitis
Chronic atrophic rhinitis is a chronic inflammation of nose characterised by atrophy of nasal mucosa, including the glands, turbinate bones and the nerve elements supplying the nose. Chronic atrophic
Chronic atrophic rhinitis
rhinitis may be primary and secondary. Special forms of chronic atrophic rhinitis are rhinitis sicca anterior and ozaena.
Classification and external
resources
Specialty otolaryngology
Contents ICD-10 J31.0 (http://apps.wh
o.int/classifications/ic
Signs and symptoms
d10/browse/2016/en
Etiology
Secondary atrophic rhinitis #/J31.0)
Unilateral atrophic rhinitis ICD-9-CM 472.0 (http://www.icd
Pathology 9data.com/getICD9C
Diagnosis ode.ashx?icd9=472.
Treatment
0)

History DiseasesDB 30798 (http://www.dis

See also easesdatabase.com/
ddb30798.htm)
References
External links MedlinePlus 001627 (https://medli
neplus.gov/ency/artic
le/001627.htm)

Signs and symptoms MeSH D012222 (https://ww

w.nlm.nih.gov/cgi/me
most commonly seen in females sh/2018/MB_cgi?field
reported among patients from lower socioeconomic groups.[1][2] =uid&term=D012222)
The nasal cavities become rheumy and are filled with foul smelling crusts which are black or dark green and dry, making expiration painful and difficult.
Microorganisms are known to multiply and produce a foul smell from the nose, though the patients may not be aware of this, because their elements (responsible for the perception of smell) have become atrophied. This is called merciful anosmia.
Patients usually complain of nasal obstruction despite the roomy nasal cavity, which can be caused either by the obstruction produced by the discharge in the nose, or as a result of sensory loss due to atrophy of nerves in the nose, so the patient is
unaware of the air flow. In the case of the second cause, the sensation of obstruction is subjective.
Bleeding from the nose, also called epistaxis, may occur when the dried discharge (crusts) are removed.
Septal perforation and dermatitis of nasal vestibule can occur. The nose may show a saddle-nose deformity.
Atrophic rhinitis is also associated with similar atrophic changes in the pharynx or larynx, producing symptoms pertaining to these structures. Hearing impairment can occur due to Eustachian tube blockage causing middle ear effusion.
Permanent loss of smell and impairment of taste may also be a result of this disease, even after the symptoms are cured.

Etiology
Causes can be remembered by mnemonic HERNIA:

Hereditary factors: the disease runs in families

Endocrine imbalance: the disease tends to start at puberty and mostly involves females
Racial factors: whites are more susceptible than natives of equatorial Africa
Nutritional deficiency: vitamins A or D, or iron
Infection: Klebsiella ozaenae, diphtheroids, Proteus vulgaris, E. coli, etc.
Autoimmune factors: viral infection or some other unidentified insult may trigger antigenicity of the nasal mucosa.

Secondary atrophic rhinitis

Specific infections, such as syphilis, lupus, leprosy and rhinoscleroma, may cause destruction of the nasal structures leading to atrophic changes. Atrophic rhinitis can also result from long-standing purulent sinusitis or radiotherapy of the nose, or as a
complication of surgery of the turbinates.[3] The United Kingdom National Health Service has stated that "Most cases of atrophic rhinitis in the UK occur when the turbinates are damaged or removed during surgery".[4] Some authors refer to as Atrophic
rhinitis secondary to sinus surgery as the empty nose syndrome.[3]

Unilateral atrophic rhinitis

Extreme deviation of nasal septum may be accompanied by atrophic rhinitis on the wider side.

Pathology
The ciliated columnar epithelium of the nasal mucosa is replaced by stratified squamous epithelium.
Atrophy of mucosa, turbinal bones and seromucinous glands tends to occur, due to obliterative endoarteritis causing decreased blood supply, hence the supplying area atrophies.
Arrested development of paranasal sinuses.

Diagnosis

Treatment
Treatment of atrophic rhinitis can be either medical or surgical.

Medical measures include:

Nasal irrigation using normal saline[3]

Nasal irrigation and removal of crusts using alkaline nasal solutions prepared by dissolving a spoonful of powder containing one part sodium bicarbonate, one part sodium biborate and two part sodium chloride.
25% glucose in glycerine can be applied to the nasal mucosa to inhibit the growth of proteolytic organisms which produce foul smell.
Local antibiotics, such as chloromycetine.
Vitamin D2 (Kemicetine).
Estradiol spray for regeneration of seromucinous glands and vascularization of mucosa.
Systemic streptomycin (1g/day) against Klebsiella organisms.
Oral potassium iodide for liquefaction of secretion.
Placental extract injected in the submucosa.
Surgical interventions include:

Young's operation.
Modified Young's operation.
Narrowing of nasal cavities, submucosal injection of Teflon paste, section and medial displacement of the lateral wall of the nose.
Transposition of parotid duct to maxillary sinus or nasal mucosa.

History
This disorder was known since the time of ancient Egypt, almost 4,000 years ago, and descriptions of it are found in the historical medical papyri. In the Edwin Smith Papyrus (1700 BC) it was prescribed a treatment based on wine and breast milk to cure
this disease.[3] The ancient Greek and Indian civilizations were aware of atrophic rhinitis.[5]

See also
Empty nose syndrome

References
1. Dutt SN, Kameswaran M (November 2005). "The aetiology and management of atrophic rhinitis". J Laryngol Otol. 119 (11): 843–52. doi:10.1258/002221505774783377 (https://doi.org/10.1258%2F002221505774783377). PMID 16354334 (https://ww
w.ncbi.nlm.nih.gov/pubmed/16354334).
2. Bunnag C, Jareoncharsri P, Tansuriyawong P, Bhothisuwan W, Chantarakul N (September 1999). "Characteristics of atrophic rhinitis in Thai patients at the Siriraj Hospital". Rhinology. 37 (3): 125–30. PMID 10567992 (https://www.ncbi.nlm.nih.gov/pu
bmed/10567992).
3. deShazo, Richard D.; Stringer, Scott P. (2011-02-01). "Atrophic rhinosinusitis: progress toward explanation of an unsolved medical mystery". Current Opinion in Allergy and Clinical Immunology. 11 (1): 1–7. doi:10.1097/ACI.0b013e328342333e (http
s://doi.org/10.1097%2FACI.0b013e328342333e). ISSN 1473-6322 (https://www.worldcat.org/issn/1473-6322). PMID 21157302 (https://www.ncbi.nlm.nih.gov/pubmed/21157302).
4. Choices, NHS. "Non-allergic rhinitis - Causes - NHS Choices" (http://www.nhs.uk/Conditions/Rhinitis---non-allergic/Pages/Causes.aspx). www.nhs.uk. Retrieved 2017-08-12.

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4/21/2018 Chronic atrophic rhinitis - Wikipedia

5. Shehata MA (1996). "Atrophic rhinitis". Am J Otolaryngol. 17 (2): 81–6. doi:10.1016/s0196-0709(96)90000-9 (https://doi.org/10.1016%2Fs0196-0709%2896%2990000-9). PMID 8820180 (https://www.ncbi.nlm.nih.gov/pubmed/8820180).

External links
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