Original Article

Proteome-Based Systems Biology Analysis of the Diabetic

Mouse Aorta Reveals Major Changes in Fatty Acid
Biosynthesis as Potential Hallmark in Diabetes
Mellitus–Associated Vascular Disease
Holger Husi, PhD; Tom Van Agtmael, PhD; William Mullen, PhD; Ferdinand H. Bahlmann, PhD;
Joost P. Schanstra, PhD; Antonia Vlahou, PhD; Christian Delles, MD; Paul Perco, PhD;
Harald Mischak, MD, PhD

Background—Macrovascular complications of diabetes mellitus are a major risk factor for cardiovascular morbidity and
mortality. Currently, studies only partially described the molecular pathophysiology of diabetes mellitus–associated
effects on vasculature. However, better understanding of systemic effects is essential in unraveling key molecular events
Downloaded from http://circgenetics.ahajournals.org/ by guest on November 12, 2017

in the vascular tissue responsible for disease onset and progression.

Methods and Results—Our overall aim was to get an all-encompassing view of diabetes mellitus–induced key molecular
changes in the vasculature. An integrative proteomic and bioinformatics analysis of data from aortic vessels in the ­low-
dose streptozotocin-induced diabetic mouse model (10 animals) was performed. We observed pronounced dysregulation
of molecules involved in myogenesis, vascularization, hypertension, hypertrophy (associated with thickening of the
aortic wall), and a substantial reduction of fatty acid storage. A novel finding is the pronounced downregulation of
glycogen synthase kinase-3β (Gsk3β) and upregulation of molecules linked to the tricarboxylic acid cycle (eg, aspartate
aminotransferase [Got2] and hydroxyacid-oxoacid transhydrogenase [Adhfe1]). In addition, pathways involving primary
alcohols and amino acid breakdown are altered, potentially leading to ketone-body production. A number of these findings
were validated immunohistochemically. Collectively, the data support the hypothesis that in this diabetic model, there is
an overproduction of ketone-bodies within the vessels using an alternative tricarboxylic acid cycle-associated pathway,
ultimately leading to the development of atherosclerosis.
Conclusions—Streptozotocin-induced diabetes mellitus in animals leads to a reduction of fatty acid biosynthesis and
an upregulation of an alternative ketone-body formation pathway. This working hypothesis could form the basis for
the development of novel therapeutic intervention and disease management approaches.  (Circ Cardiovasc Genet.
2014;7:161-170.)
Key Words: aorta ◼ blood supply ◼ diabetes mellitus ◼ ketone bodies ◼ muscles ◼ proteomics
◼ smooth muscle ◼ systems biology

D iabetes mellitus is characterized by hyperglycemia and

recognized as one of the major contributors to health
problems worldwide.1 One of the greatest contributors to mor-
bidity and mortality in diabetics is a 2- to 8-fold increased
risk of developing vascular disease.2 Hyperglycemia affects
both macrovascular (coronary artery disease, peripheral
arterial disease, and stroke) and microvascular complica-
tions (diabetic nephropathy, neuropathy, and retinopathy).
Affected vessels display major histological changes,3 includ-
ing increased intima-media thickness, in part as a result of
increased vascular smooth muscle cell proliferation, adhesion,
and migration,4 as well as elevated extracellular matrix, in par-
ticular collagen, deposition. The overproduction of elevated
extracellular matrix proteins and increased cross-linking of
collagen can lead to aortic fibrosis, a major component in dia-
betic hyperglycemia.5
Editorial see p 100
Clinical Perspective on p 170
The molecular mechanisms, as they are currently
known, of the development of these vascular lesions dur-
ing hyperglycemia are complex, involving an increase in

Received February 21, 2013; accepted January 29, 2014.

From the Institute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK
(H.H., T.V.A., W.M., C.D., H.M.); Universitätsklinikum des Saarlandes, Homburg/Saar, Germany (F.H.B.); Institut National de la Santé et de la Recherche
Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Université Toulouse III Paul-Sabatier, Toulouse, France (J.P.S.); Biomedical
Research Foundation, Academy of Athens, Athens, Greece (A.V.); School of Biomedical and Biological Sciences, Plymouth University, Plymouth, UK
(A.V.); Emergentec Biodevelopment GmbH, Vienna, Austria (P.P.); and Mosaiques Diagnostics GmbH, Hannover, Germany (H.M.).
The Data Supplement is available at http://circgenetics.ahajournals.org/lookup/suppl/doi:10.1161/CIRCGENETICS.113.000196/-/DC1.
Correspondence to Holger Husi, PhD, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Joseph Black Bldg, Room B2-21,
Glasgow, G12 8QQ, United Kingdom. E-mail Holger.Husi@glasgow.ac.uk
© 2014 American Heart Association, Inc.
Circ Cardiovasc Genet is available at http://circgenetics.ahajournals.org DOI: 10.1161/CIRCGENETICS.113.000196

161
 162  Circ Cardiovasc Genet  April 2014
proinflammatory signals (eg, activation of nuclear factor-κB,
adhesion molecules, tumor necrosis factor-α, interleukin-1β
and ­interleukin-6).6 Downstream of these proinflammatory
factors extracellular signal-regulated protein kinase-1, c-Jun
NH2-terminal protein kinase-1 and -2, and p38 are activated.7
A further hallmark in the development of diabetic vascular
lesions is the production of reactive oxygen species, result-
ing in inactivation of nitric oxide and appearance of advanced
glycation end-products, further aggravating vascular tissue
damage.8 Several proteins have been proposed as targets for
hyperglycemic changes in the vascular smooth muscle cells,
including protein kinase C and the inositol trisphosphate- and
ryanodine receptors.9 Inositol 1,4,5-trisphosphate-sensitive
and ryanodine-sensitive stores are the major contributors to
Ca2+ homeostasis in vascular smooth muscle cell.10 The com-
plexity of the vascular response to diabetes mellitus is fur-
ther exemplified by a recent proteomic study, showing that
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the most prominent diabetes mellitus–associated changes
were in proteins linked to oxidative stress and the structure/
function of myofibrils and microfilaments, with decreased
levels of glycolytic enzymes and mitochondrial electron
transport system complex components.11 Further studies sug-
gest an association of mitochondrial dysfunction, persistent
­hyperglycemia-induced mitochondrial oxidative stress,12 and
decreased activity of several antioxidant enzymes in diabetic
hyperglycemia in both rats and humans.13
This existing, yet disparate, molecular evidence on diabetes
mellitus–associated effects on vasculature indicates a need for
a holistic approach, interlinking the findings. Such detailed
analysis and further integration of data in a systems medicine
approach is proposed to provide a better understanding of dia-
betes mellitus–associated vascular changes and to open new
avenues toward improved interventional therapies.
A well-established and accepted model of hyperglycemia is
streptozotocin-induced diabetes mellitus in animals,14 which
displays many of the hallmarks of diabetes mellitus–evoked
vascular pathology. In the current study, we used proteomic pro-
filing to investigate aortic vessels from s­ treptozotocin-induced
diabetic mice and controls, followed by functional bioinfor-
matics analyses to investigate deregulated processes on a
molecular level. Our analysis recapitulates and further links
many of the known molecular hallmarks of diabetic arteri-
opathy at the pathway level and in addition suggests diabetes
mellitus–induced production of ketone-bodies in the vessels.
Methods
Materials
All chemicals were obtained from Sigma-Aldrich (Gillingham, UK)
unless stated otherwise.
Animal Model
Seven-week-old C57BL/6 male mice were obtained from Charles
River (Sulzfeld, Germany) and housed at the Saarland University ani-
mal facility. All animals had free access to a standard laboratory diet
with free access to water. All procedures were performed according to
Federation for Laboratory Animal Science Associations (FELASA)
guidelines and were approved by local authorities. Experimental
diabetes mellitus was induced in 8-week-old ­ weight-matched
mice by multiple low doses of streptozotocin. Mice were injected
intraperitoneally with either 50 mg/kg body weight streptozotocin
(Sigma-Aldrich) in 50 mmol/L sodium citrate (pH 4.5) or sodium
citrate buffer for 5 consecutive days. After 20 weeks of hypergly-
cemia, the animals were euthanized. Thoracic and abdominal aortas
were removed and frozen in liquid nitrogen and stored at –80°C until
sample preparation for mass spectrometry (MS) or carefully frozen in
liquid nitrogen vapor for immunohistochemistry.
Blood Glucose Measurements
Blood glucose was measured 20 days after the first streptozotocin
injection and monthly thereafter (Glucometer Elite System; Bayer,
Leverkusen, Germany). Animals with glucose levels >12 mmol/L
after 4 hours of fasting were considered diabetic. Animals that were
not hyperglycaemic within 20 days after the first streptozotocin injec-
tion were excluded. Mice received no insulin. Ketonuria did not occur.
Sample Preparation and Mass
Spectrometry Analysis
Tissue samples were weighed and extracted using the Filter Aided
Sample Preparation method15 (see Methods in the Data Supplement
for a detailed description) and analyzed on an O ­ rbitrap-Velos FTMS
(Thermo-Finnigan, Bremen, Germany) as described,16 operated
in a data-dependent mode (top 40) to switch between MS and MS/
MS acquisition, using collision-induced dissociation. Data files were
searched against the mouse IPI database using SEQUEST, integrated in
Proteome Discoverer (Thermo Fisher Scientific, Hemel, UK), setting
carbamidomethylation as fixed and phosphorylation, methionine, and
proline oxidation as variable modifications. Mass error windows of 10
ppm and 0.8 Da were allowed for MS and MS/MS, respectively. Peptide
data were extracted using high peptide confidence and top 1 peptide
rank filters. Statistical P value analysis of the normalized precursor ion
peak areas was performed using the Wilcoxon and Mann–Whitney test.
Source MS and MS/MS data files are available at PeptideAtlas (http://
www.peptideatlas.org/) with the identifier PASS00380.
Bioinformatics Analysis
Analysis was performed on proteins with P values ≤0.05 (72 pro-
teins). Functional association was done using the controlled vo-
cabulary of the Proteomics Analysis DataBase protein classification
system (PADB.org). Gene Ontology (GO) keyword-cluster analysis
was performed using the CluGO CytoScape plug-in (www.cyto-
scape.org).17 Interactome analysis was performed using the Michigan
Molecular Interactor plug-in (mimi.ncibi.org).18 The condensed pro-
tein interaction analysis was conducted by searching for direct as-
sociations, followed by stepwise expansion to tie in other molecular
clusters. This analysis uncovers novel signaling pathways because
molecules with similar cellular involvement tend to cluster together
through physical interactions, such as those found in molecular ma-
chines.19 Metabolic pathway analysis was done with PathVisio (www.
pathvisio.org).20 Additional enzymatic reactions were retrieved from
BRaunschweig ENzyme Database (BRENDA) (http://www.brenda-
enzymes.org/). The disease analysis is based on known or inferred ge-
netic disorders associated with mutations of specific genes as stored
in the Online Inheritance in Man (OMIM) database using the human
orthologous genes, respectively. The successive pathway analysis
was done using the CytoScape iRefScape plug-in (irefindex.uio.no/
wiki/iRefScape_1.0)21 by gene-name mapping and OMIM accession-
number extraction of the resulting networks.
Histology and Immunohistochemistry
Cryosections were fixed for 10 minutes in acetone, followed by anti-
gen retrieval using 0.1 mol/L HCl/KCl for 10 minutes. After blocking
in PBS containing 10% fetal calf serum (FCS), sections were incu-
bated with primary antibodies overnight (myosin [Sigma], smooth
muscle actin [Santa Cruz], Gsk3β, fatty acid synthase [Fasn; Santa
Cruz], pyruvate dehydrogenase kinase isoform 4 [Pdk4; Abcam],
mitochondrial Got2 [Abcam], mitochondrial Adhfe1 [Proteintech]),
followed by incubation with Cy3 conjugated secondary antibodies
 Husi et al   Systems Biology Analysis of the Diabetic Aorta   163
(Jackson Laboratories). Images (×200 and ×400 magnification)
were captured using a Zeiss LSM510 Meta confocal microscope
and Zeiss LSM software (Zeiss, Germany). Medial thickness was
measured using LSM Image software (Zeiss, Germany) of blinded
cryosections (n=3). Four random measurements were collected per
section, and 3 sections were analyzed per animal. Oil red O staining
was performed on 1­ 0-μm cryosections fixed in 10% formalin. After
incubation in propylene glycol, sections were incubated in Oil red
O solution at 60°C and subsequently differentiated in 85% propyl-
ene glycol. After mounting, images were captured using an Axiophot
microscope (Zeiss) and an Axiocam camera (Zeiss) using bright-
field setting. Histograms and quantification of fluorescence signal
for immunohistochemistry stainings were generated by splitting the
red-green-blue (RGB) color channels and calculating the ratio be-
tween the red channel (probe) and the blue (nuclear stain) for each
individual panel using ImageJ. The Oil red O histogram used a calcu-
lation of the red versus the sum of green and blue channels. This was
done using blinded sections, and 3 random measurements were taken
per section. Statistical significance was calculated using unpaired t test
(see Methods in the Data Supplement for a detailed description).
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Results
Animal Model
Mice became diabetic within 2 weeks after streptozotocin
injection, and hyperglycemia persisted throughout the 19-week
experimental period. Average blood glucose levels were 395
mg/dL in diabetic mice. At the end of week 19, bodyweight
gain was 20% in diabetic and 28% in control animals (Table 1).
Values for the medial thickness were significantly higher for
diabetic aortas (28 μm) than for control aortas (19 μm), indi-
cating thickening of the vascular wall in diabetic mice (Table 1;
Figure 1). There was no significant difference in total protein
content between groups of diabetic and control aortas.
Mass Spectrometry Analysis and Data Acquisition
Proteins from 5 aortic control and 5 aortic diabetic samples
were analyzed by liquid chromatography tandem mass spec-
trometry. A total of 442 725 MS/MS-spectra were matched to
9257 peptides, corresponding to 2205 unique proteins (Table I
in the Data Supplement). The protein identification false-dis-
covery rate was 0.38%. A total number of 996 proteins were
found in both diabetic and control samples. A total number of
600 proteins could only be observed in control samples and
609 only in aortas from diabetic mice. A total of 72 entries, of
which 18 were only found in 1 group, were selected as likely
differing in distribution, based on a nominal P value <0.05
(Tables I and II in the Data Supplement). The most prominent
changes were the downregulation of metabolic enzymes, such
Table 1.  Parameters of Animals and Aortas in Control and
Diabetic Mice
Measurement Control Diabetic
Blood glucose, mg/dL 116.2±4.6 (5) 464.6±51.9 (5)
Body weight, g 34.1±1.2 (5) 27.6±1.1 (5)
Weight change, % (0–19 wk) 127.9±3.4 (5) 119.9±1.7 (5)
Aortic intima-medial 19.3±4.2 (3×2) 28.5±5.9 (3×3)
thickness, μm
Individual values for glucose levels and weight were measured at week 19
and include the SEM. Aorta thickness was measured at week 20. Replicates (n)
are shown in parentheses.
as ATP-citrate synthase [Acly], transketolase [Tkt], pyruvate
carboxylase [Pc], liver carboxylesterase N [Ces1c], and iso-
citrate dehydrogenase [Idh2]. Adjustment of P values using
Benjamini–Hochberg correction for multiple testing showed
a lack of statistical power, and none of the individual peptides
achieved statistical significance after adjustment for multiple
testing using the Benjamini–Hochberg correction. However,
comprehensive pathway mapping is not dependent on indi-
vidual statistical significances.
Bioinformatics Data Analysis Workflow
Proteins exhibiting clear differences in distributions between
treated and untreated samples (P<0.05; Table II in the Data Sup-
plement) were used as input data in the different bioinformatics
approaches, including GO, interactome (Michigan Molecular
Interactor), or metabolic pathway (PathVisio) analysis, as well
as literature and OMIM database mining, aiming to capture
the maximum available information and identify differentially
expressed pathways and key molecules in aortic vessels of dia-
betic mice. Figure 2 depicts the overall workflow, and Table 2
summarizes the results of the individually performed bioinfor-
matics approaches. Brief explanations on the applied in silico
bioinformatics analyses are provided in the following sections.
GO Analysis, Interactome Mapping, and
Metabolic Pathways
GO analysis is based on statistical testing of associated key-
words (retrieved from the GO database) for each molecule. The
interactome cluster analysis provides information on group
clustering and physical linkage. We also used metabolic path-
way analysis by protein mapping to preassembled metabolic
and signaling pathways. Significant pathways were identified
after statistical testing of molecules contained in each individ-
ual pathway map according to the respective pathways analysis
software. The results indicate a clear upregulation of myofibril-
lar/muscle contraction pathways involved in muscle function
and a downregulation of cell cycle pathways (with key pro-
teins Gsk3β and ­14-3-3), inhibitors involved in the response
to stimulus (Serpins), and the GO-group cluster of enzymatic
processes involved in pentose-phosphate shunt (transaldolase
[Taldo1], Tkt, decarboxylating 6-phosphogluconate dehy-
drogenase [Pgd]) and fatty acid (acetyl-CoA carboxylase 1
[Acaca], Fasn, estradiol 17-β-dehydrogenase 12[Hsd17b12])
pathways (Figures I and IIA, IIB). We also observed a marked
upregulation of proteins associated with muscle metabolic
turnover (glycolysis) along with the pronounced downregula-
tion of fatty acid metabolism (Figure 3). In addition, an alter-
native ketone-body formation pathway, linked to tricarboxylic
acid (TCA) cycle metabolites, seems to be upregulated.
OMIM Disease Clusters and Literature/Text Mining
To explore whether known human diseases, which might be
associated with diabetic conditions, map to the statistically sig-
nificant proteins observed in this study, we examined associa-
tions of molecules to human conditions using iRefScape and
data mining of the OMIM database (Table III in the Data Sup-
plement). High relevance of the observed proteomics changes
in the streptozotocin-treated mouse to human diabetes melli-
tus and diabetic complications can be observed. Upregulated
 164  Circ Cardiovasc Genet  April 2014
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molecules indicate a development of muscle fibers (myosin-2
[Myh2]), as well as the downregulation of muscle-affecting
proteins involved in myopathy (filamin-A, ADP/ATP trans-
locase 1 [Slc25a4], and peripherin [Prph]). Surprisingly, 1
member of the myosin family, Myh11, was observed to be
downregulated, whereas all others demonstrated a pronounced
Figure 2.  Schematic diagram of the overall workflow and data
analysis. Samples from 10 aortic samples (5 from each group)
were analyzed by LC-MS/MS (Table I in the Data Supplement),
resulting in 72 statistically significant proteins using cutoff values
of P<0.05 and fold changes of ≥1.4 (Table II in the Data Supple-
ment). Downstream analysis was performed using various tools,
such as gene ontology (GO) analysis (Figure I in the Data Supple-
ment), interactome mapping (Figure II in the Data Supplement),
OMIM disease analysis (Table III in the Data Supplement), meta-
bolic pathway analysis (Figure III in the Data Supplement), and lit-
erature and text mining (Table 3; Table IV in the Data Supplement),
resulting in a unified pathway model (Figure 3), of which key com-
ponents were validated by immunohistochemistry (Figure 4).
Figure 1.  Initial assessment of the animal model.
Measurement of free glucose (A) and body weight
(B) over the experimental time span (white bars,
control mice; black bars, diabetic mice) and repre-
sentative cross-sections of descending aortas from
nondiabetic control (C, left) and diabetic (C, right)
mice stained against smooth muscle actin (red).
Sections were also used to measure the thickness
of the media (double white arrow, scale bar, 50 μm).
STZ indicates streptozotocin.
upregulation. Another pronounced disease cluster shows an
orchestrated downregulation of vesicular-affecting proteins,
leading to arterial hypertension (apolipoprotein A-I [Apoa1]),
aortic aneurysm, degenerative changes in the aortic wall,
increased mean aortic root diameter, aortic stiffness (Myh11),
coronary artery disease (platelet glycoprotein 4 [Cd36]), and
narrowing of the aorta (transaldolase). In addition, mitochon-
drial metabolic pathway perturbances are also indicated (pyru-
vate carboxylase, mitochondrial leucine-rich Pentatricopeptide
repeat (PPR) motif-containing protein [Lrpprc]). Substratifica-
tion of the input proteins using keywords embedded in the liter-
ature MESH-terms into groupings related to diabetic conditions
is summarized in Table 3. This analysis showed that proteins
involved in fatty acid storage, glucose metabolism, and apop-
tosis were all downregulated, whereas molecules taking part
in myogenesis and vascularization, as well as being linked to
hypertension and hypertrophy, were substantially upregulated.
Combinatorial Analysis and ­Interlinking-
Affected Pathways
Pathway assembly was performed by interlinking the findings
and generating a global denovo pathway assembly using Path-
Visio. Interlinking of the aforementioned analyses revealed a
general downregulation, from glucose to the end-products of
the fatty acid biosynthesis pathway, an upregulation of the
classical muscle-based energy metabolism from glucagon to
lactate involving the metabolic pathway controlling enzyme
Pdk4, a compensatory (upregulated) pathway from primary
alcohols such as ethanol to acetyl-CoA, and altered alterna-
tive bypass-mechanisms of the TCA cycle (Figure 3). This
collection of enzymes associated with the use of TCA cycle
metabolites in particular can form a pathway that directly leads
to the formation of ketone-bodies through incorporation of
­ -glutamate via Got1/2, mitochondrial L
l ­ -2-hydroxyglutarate
dehydrogenase, and Adhfe1. The first 2 enzymes were found
to be upregulated in our proteomic analysis, whereas Adhfe1
was not detected but is predicted to produce the end-prod-
uct. The same end-product is also formed by breakdown and
 Husi et al   Systems Biology Analysis of the Diabetic Aorta   165
Table 2.  Summarized Results of Individual Bioinformatics Analyses
Analysis Upregulated
GO Myofibrillar
Interactome Muscle tissue, transcriptional elements
OMIM Muscle fibers
Metabolic pathways Energy metabolism from glucagon to lactate,
accumulation of acetyl-CoA, breakdown, and
deamination of amino acids
Literature/text mining Myogenesis, vascularisation, hypertension,
hypertrophy
The output of the various analysis approaches, using the 72 statistically significant differentially expressed proteins, is shown. GO indicates gene
ontology; NF-κB, nuclear factor-κB; OMIM, Online Mendelian Inheritance in Man; and TNF, tumor necrosis factor.
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deamination of amino acids, also implied to be upregulated
in the disease pathway model. Suggested signaling pathways
modulated in streptozotocin-treated diabetic animals include
tumor necrosis factor-α, nuclear factor-κB, and pathways
downstream of insulin-signaling involving Gsk3β, protein
kinase A, and calcium/calmodulin-dependent protein kinase
type II (Figure III in the Data Supplement), in all cases being
downregulated in the diabetic versus control animals.
Validation of Findings
We subsequently sought to verify the most prominent findings
using immunohistochemistry. Our criteria for target selection
for further validation included the placement of the candidate
proteins in apparently disconnected molecular pathways, in
combination to reagent (antibodies) availability. Specifically,
prototypic proteins, actin, GSK3b, myosin, and Fasn were
chosen. On the basis of this pathway analysis, we extended
the validation to also include Pdk4, Got2, and Adhfe1. As
shown in Figure 4, immunohistochemistry confirmed the
changes observed in the proteomic analysis and suggested
after the bioinformatics analysis. Histograms for each stain-
ing are shown (Figure 4) as indicators of protein expression
changes, nevertheless not reflecting absolute values. Smooth
muscle actin staining revealed that streptozotocin-treated
animals developed increased medial thickness, although no
increase in the level of smooth muscle actin was observed (Fig-
ure 1C). Interestingly, the smooth muscle of diabetic animals
displayed increased myosin staining (Figure 4A), confirming
the observed upregulation of proteins involved in myogenesis
and muscular functions. To substantiate the link between dia-
betes mellitus and hypertension, we examined the expression
levels of Gsk3β (Figure 4B) and could demonstrate a down-
regulation of this molecule in aortas of streptozotocin-treated
animals. To investigate the proposed reduction in fatty acid
biosynthesis pathways, the expression of Fasn (Figure 4C)
was also examined. Staining revealed a significant reduction of
the protein in diabetic animals. Diabetic animals also revealed
reduced Oil red O staining, indicating a general reduction in fat
deposits in the tissue (Figure 4D). This is most likely because
of a reduction in the fatty acid synthesis, as indicated by the
Downregulated
Protein targeting, cell cycle, inhibitors involved in the response to stimulus,
pentose-phosphate shunt, fatty acid metabolism
Fatty acid biosynthesis and metabolism, oxidative phosphorylation, insulin,
mitogen-activated protein kinase (MAPK), TNF-α, and NF-κB signaling
Myopathy, vesicular-affecting proteins, arterial hypertension, aortic aneurysm,
degenerative changes in the aortic wall, increased mean aortic root diameter,
loss of smooth muscle cells, aortic stiffness, coronary artery disease,
narrowing of the aorta, mitochondrial metabolic pathway perturbances
Pentose-phosphate pathway, glycolysis, pyruvate metabolism
Fatty acid storage, glucose metabolism, apoptosis
reduced Fasn staining and proteomic analysis and because of
the increased muscularization of the tissues and consequent
shift in metabolism. Pathway analysis indicated an increase
of the glycolytic pathway, in part, commonly associated with
muscle metabolism, leading to increased lactate, pyruvate,
and acetyl-CoA accumulation, which is controlled by Pdk4 by
inhibiting the pyruvate to acetyl-CoA conversion. An increase
in this kinase, as suggested by our proteomic analysis, was
confirmed by immunohistochemistry (Figure 4E) and could
be a protective mechanism of vascular smooth muscle cells
under hypoxic conditions to avoid the accidental activation of
the oxygen-dependent TCA cycle. Metabolic pathway analysis
also strongly indicated a direct link to ketone-body formation
using an unconventional alternative pathway linked to the TCA
cycle. To substantiate this, we performed staining for Got2 as
the branching point from the TCA cycle and could clearly
show an increase of this molecule in aortas of streptozotocin-
treated animals, thereby confirming proteomic data for this
molecule (Figure 4F). The ultimate step in this ketone-body
formation process involves the ­iron-dependent alcohol dehy-
drogenase Adhfe1. Although we could not detect this protein
in the proteomic analysis, we found it to be upregulated in the
streptozotocin-treated animals’ aortas by immunohistochemis-
try, in line with our predictions (Figure 4G).
Discussion
Diabetes mellitus–associated complications affecting the
macro- and microvasculature are major causes of mortal-
ity and morbidity, but the underlying mechanisms remain
relatively poorly understood.22 Analysis of the aortic pro-
teome could provide valuable insights in the development
of diabetes mellitus–associated macrovascular patholo-
gies.23 ­Streptozotocin-induced diabetes mellitus in mice is
aw ­ ell-established model to investigate processes leading to
diabetic conditions, such as cardiomyopathy, nephropathy,
arteriopathy, stroke, and ultimately organ failure.24
Inspired by the data from Didangelos et al,25 we initi-
ated a comprehensive proteomic study of diabetic aortas in
the streptozotocin model in comparison with untreated con-
trols coupled with extensive bioinformatics and systems
 166  Circ Cardiovasc Genet  April 2014
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Figure 3.  Alternative metabolic pathway analysis in the formation of ketone-bodies. Proteins involved in metabolic pathways were
mapped onto known pathways, including glycolysis, fatty acid pathways, pyruvate/lactate pathways, tricarboxylic acid cycle bypass
pathway, amino acid breakdown, and ketone-body production. Green, downregulated; red, upregulated. Proteins that were validated by
immunohistochemistry are highlighted (blue frame).
 Husi et al   Systems Biology Analysis of the Diabetic Aorta   167

Table 3.  Analysis of Group Clusters

Endoplasmic Average Fold
Functional Group Gene Total Cytoplasm Mitochondria Reticulum Nuclear Secreted Muscle Other Change
Fatty acid storage Cd36, Got1, Fasn, Acaca, Ces1c, 17 8 4 2 3 … … 2 0.15
and glucose Plin1, Hsd17b12, Fabp4, Pgd,
metabolism Tkt, Gpd1, Idh2, Pc, Eno1, Taldo1,
Kdm4c, Slc25a1
Apoptosis Fbxo9, Gsdmc2, Lrpprc, Ankrd44, 13 3 1 … 3 1 … 5 0.4
Fabp3, Vmn2r61, Acly, Serpina1e,
Cct6a, C9orf21,Cobra1, Hist2h2bb,
Hist1h2bf
Myogenesis/ Myh8, Myh2, Myh1, Myh4, Myh13, 13 2 … … 4 … 9 … 4.53
vascularisation Myl2, Csrp1, Tagln, Myh11,
Champ1, Rrn3, Eef1a1, Atp2a1
Oxidative stress Mug1, Ywhab, Ywhae, Ywhaz, 8 5 … … … 2 1 … 1
Ywhag, Akr1b1, Mb, Hpx
Hypertension/ Actn2, Flna, S100a6, Apoa1, Myl3, 7 4 … … 3 1 2 … 7.78
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hypertrophy Cryab, Gsk3β

Other Myom2, Prph, Slc25a44, Aqpep, 14 2 3 … … 2 1 6 1.47
Fsip2, Tmem229a, Samd15,
Crip3, Crtac1, Mob3a, Mp68,
D030046N08Rik, Serpina1b, Mast2
Statistically significant proteins (n=72; P<0.05) were analyzed based on their potential involvement in diabetes mellitus or diabetes mellitus–associated pathologies
based on literature searches, OMIM annotations, or KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways, and grouped accordingly. The cellular location was
derived from the UniProt database, and some proteins are listed as both cytoplasmic and nuclear. The average fold changes were calculated by omitting any entries that
were unique to 1 group (streptozotocin treated or control).

biology analysis. We observed substantial changes in 72
(P<0.05) of 2205 detected nonredundant aortic proteins. A
full ­molecule-by-molecule discussion of the differentially
expressed proteins found in this study and their potential
or known involvement in diabetic conditions is provided in
Table IV in the Data Supplement. Some of these proteins were
previously reported as diabetes mellitus–associated (18 mol-
ecules), but the majority (54 molecules) was not described in
the context of diabetes mellitus.
A characteristic example of the former category is the fatty
acid–binding protein 3 (Fabp3), showing elevated expression
levels in diabetic aortas. Fabp3 is involved in fatty acid trans-
port, and its overexpression was reported to induce apoptosis.26
In prediabetic, impaired glucose-tolerant conditions, elevated
levels of Fabp3, and an associated thickening of the arterial
intima-media have been shown,27 in accordance with our results.
Because both muscle cells and adipocytes express Fabp3,28
streptozotocin diabetic vessels have increased intima-media
thickening and reduced Oil red O staining in the adventitia; we
consider it highly likely that increased Fabp3 expression levels
are in vascular smooth muscle cells. This may also apply to fatty
acid–binding protein 4 (Fabp4), downregulated in our study,
which was described to impair the insulin-dependent nitric oxide
pathway in vascular endothelial cells.29 Elevated Fabp4 serum
levels have been shown to be associated with diabetes mellitus,
diabetic nephropathy, stroke, and vascular inflammation.30 Thus,
the observed downregulation in aortic tissue might be a conse-
quence of active exocytosis or a cellular protective event.
In line with existing knowledge supporting a major role of
oxidative stress in diabetic conditions, we observed increased
levels of the well-characterized oxidative stress protein Aldose
reductase (Akr1b1). This molecule is a key enzyme in diabetes
mellitus–induced oxidative stress,31 and its overexpression has
been shown to result in higher susceptibility to myocardial
ischemic injury.32 Nuclear factor-κB induces Akr1b1 expres-
sion under high glucose conditions,33 and recent findings sug-
gest that it is also the primary prostaglandin F synthase and
possibly a modulator of other signaling molecules.34
A substantial number of modulated proteins observed in
this study (Table 3) has been reported previously to be linked
to hypertrophy and hypertension, shown to coexist in diabetes
mellitus35 and also reported to occur in streptozotocin-treated
animals.36
Deletion of Gsk3β in mice was shown to lead to hypertro-
phic cardiomyopathy secondary to cardiomyoblast hyperpro-
liferation.37 We observed a pronounced downregulation of this
protein by both our proteomic screen and immunohistochem-
istry of the diabetic aortas, and our data implicate for the first
time that reduced Gsk3β-levels occur in aortas in streptozoto-
cin-induced diabetic conditions. If confirmed in humans, this
finding may consequently lead to a n­ ovel-targeted approach
in disease management and diagnosis of diabetic conditions.
Indeed, Gsk3β was selected as a potential therapeutic target in
human type 2 diabetes mellitus,38 based on observed increased
expression and activation of this protein in human muscle tis-
sue39 and mouse models.40 In animal carotid arteries, vascular
lesions lead to an upregulation of glucose metabolism in vas-
cular smooth muscle cells and promote an antiapoptotic path-
way that is associated with the inactivation of Gsk3β.41 Our
observed downregulation could, therefore, be a direct effect of
an apparent upregulation of glycolytic enzymes.
On the basis of the systems biology approach in this study,
we were able to determine potential correlations of the dif-
ferent pathways and indicate that many pathways involved
 168  Circ Cardiovasc Genet  April 2014

in diabetes mellitus show substantial overlap. Of the most

relevant findings, metabolic pathway analysis suggests that
ketone-body formation is upregulated through an alternative
pathway. Starvation and diabetes mellitus induce an upregu-
lation of glucocorticoid signaling, resulting in elevated lev-
els of Pdk4,42 which we also observed in our study. Pdk4 is
the key mediator in preventing the conversion of pyruvate to
­acetyl-CoA by inhibiting pyruvate dehydrogenase complex C.
In the liver, this inhibition enables ketone-body synthesis from
fatty acids and ketogenic amino acids rather than 3 carbon
compounds, which are then available for gluconeogenesis in
the liver to maintain blood glucose levels.43 Our data indicate
that activation of the glycolytic mechanism and co-occurring
inhibition of the pyruvate to acetyl-CoA metabolic step may
lead to an activation of an alternative TCA-bypass mechanism
involving Got2, oxaloacetate, and l-glutamate, leading to a
production of 2-oxoglutarate. This mitochondrial step may
Downloaded from http://circgenetics.ahajournals.org/ by guest on November 12, 2017

be supported by the observed upregulation of the glutamate/

aspartate exchanger aspartate glutamate carrier 1 (Slc25a12),
which imports glutamate in exchange for aspartate. Got2, a
key enzyme for endogenous sulfurdioxide production, has
been implicated in isoproterenol-induced myocardial injury,44
but its role in diabetes mellitus is unknown. The next molecule
in this alternative pathway is L-2-hydroxyglutarate dehydro-
genase, known to produce 2-hydroxyglutarate45 and upregu-
lated in our proteomic screen; however, no information exists
on whether it is involved in streptozotocin-induced diabetes
mellitus. The ultimate enzyme in this novel pathway, Adhfe1,
which forms β-hydroxybutyrate, and which we postulate to
be part of this pathway, could be shown to be upregulated
by immunohistochemistry. Adhfe1 is expressed in adipose
tissue,46 but involvement in diabetic conditions has not been
described. This, combined with an elevated breakdown of
amino acids, might lead to the localized overproduction of
ketone-bodies. Uncontrolled production of ketone-bodies
leads to ketosis and ultimately ketoacidosis,47 1 of the hall-
marks of type I diabetes mellitus. Our results suggest that
this mechanism occurs locally within the macrovasculature
and is not a product of the classical ketone-body formation
Figure 4.  Immunohistochemical analysis of diabetic mouse by β-oxidation because all molecules involved in this path-
aorta. A, Aorta from streptozotocin (STZ)–treated animals dis- way that we could detect are downregulated (Figure III, inset
play increased myosin staining (red) in the media the of the in the Data Supplement). The overall contribution of locally
vessel wall, (B) reduced glycogen synthase kinase-3β (Gsk3β)
staining (red) in adventitia of diabetic mice, (C) reduced fatty produced ketone-bodies to the total pool found in blood at this
acid synthase (Fasn) staining (red) in adventitia of treated ani- stage is unclear; however, it is estimated to have a minimal
mals, (D) reduced fat deposition in adventitia of treated mice as effect on distant tissues in subjects with diabetes.
shown by Oil red O staining, (E) increased pyruvate dehydroge- In summary, we have identified several proteins and path-
nase kinase isoform 4 (Pdk4) staining (red), (F) increased aspar-
tate aminotransferase (Got2) staining (red), and (G) increased ways implicated in the pathogenesis of diabetic arteriopa-
­hydroxyacid-oxoacid transhydrogenase (Adhfe1) staining (red). thy. Key findings include decreased glycolysis and fatty acid
DAPI (4',6-diamidino-2-phenylindole) (blue) is used to stain metabolism, a pronounced increase in vascularization, oxi-
nuclei. Size bar shown in the lower corner of A to G (left) is
50 μm. Histograms show ratios between red and blue chan- dative stress-response proteins, apoptosis modulators, and
nels of the individual panels apart from Oil red O, which is the molecules involved in hypertrophy and hypertension. Strong
ratio between red and blue+green channels. The mean values evidence supporting production of ketone-bodies locally
of 9 measurements each (originating from 3 independent ani- within the vessels is provided, and key molecules involved
mals per category), including the SEM, the Student P value, and
the calculated fold changes from the immunohistochemistry in this process are highlighted. However, limitations, such as
analysis, as well as the MS results shown underneath. aAver- transferability of results from the animal model to human dis-
aged across all myosin isoforms observed, bonly found in control ease, suboptimal statistical evidence because of relatively low
samples, conly found in STZ-treated samples, and dnot found by
mass spectrometry.
sample numbers, and lack of corroborative metabolic infor-
mation, still persist. Nevertheless, confirmatory evidence was
collected to justify further validation studies in humans. In
 Husi et al   Systems Biology Analysis of the Diabetic Aorta   169
addition, given the importance of post-translational modifica-
tions in protein function, their investigation in relation to phe-
notype development is warranted. Such targeted approaches
investigating post-translational modifications and activities
of selected proteins, as well as providing local measurements
of metabolites through advanced metabolomics techniques,
should now be applied. Our preliminary in silico comparison
of the observed molecular alterations in the mouse model ver-
sus molecular alterations in human diseases presented herein
strongly supports that such endeavors are justified.
Collectively, this study contributes a significant number of
proteomics data to the current knowledge on vascular tissue and
diabetes mellitus–related molecular changes. Even more, ana-
lyzing the data in depth using a combination of bioinformatics
tools reveals a multitude of modifications in many metabolic
and proteomic pathways that would normally require a range of
investigative techniques to be identified. A substantial propor-
Downloaded from http://circgenetics.ahajournals.org/ by guest on November 12, 2017
tion of the common chronic diseases, such as diabetes mellitus
and its cardiovascular, renal, and retinal complications, coronary
artery disease, hypertension, stroke, and vascular dementia, is all
in part caused by underlying arterial diseases.48 However, their
commonalities and identification of causative agents remain to
be investigated in many cases. The presented in-depth analysis
of alterations occurring locally (eg, at the vessels), in this case
induced by diabetes mellitus, is highly relevant and easily adapt-
able to the study of blood vessels from additional disease states
opening thus new avenues of research toward finding common
molecular denominators of multiorigin arterial diseases.
Sources of Funding
This work was supported in part by grant GA 251368 (Protoclin)
from the FP7-PEOPLE-2009-IAPP program, by the EuroKUP COST
Action (BM0702), and by European Union funding through SysKID
(HEALTH–F2–2009–241544) and European Union-MASCARA
(HEALTH-2011–278249), and a RCUK (EP/E500366/1) fellowship
to Dr Van Agtmael.
Disclosures
Dr Mischak is a co-owner of Mosaiques Diagnostics. Dr Perco is an
employee of Emergentec Biodevelopment GmbH, Austria. The other
authors report no conflicts.
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CLINICAL PERSPECTIVE
The high incidence rate of diabetes mellitus worldwide is an important healthcare issue and places a major economic burden
on society. Associated with diabetes mellitus is an elevated risk of developing vascular disease, both at the micro- and macro-
vascular level, which leads to an increase in morbidity and mortality. The macrovascular complications of diabetes mellitus
include fibrosis, plaque formation, and ultimately organ damage leading to events such as myocardial infarction and stroke.
Microvascular complications can result in diabetic nephropathy, neuropathy, and retinopathy. Effective treatment of these
conditions requires an understanding of underlying molecular changes and pathways involved in affected tissues, thereby
enabling the development of more pharmacologically targeted and effective interventions. In this study, we investigated the
molecular changes on a protein level induced by hyperglycemia using a diabetic mouse model using proteomics and systems
biology approaches. The main findings substantiate the known global hallmarks of diabetes mellitus on a protein and path-
way level and include a pronounced increase in vascularization, decreased glycolysis and fatty acid metabolism, modulation
of oxidative stress-response proteins, proteins involved in apoptotic processes, and molecules involved in hypertrophy and
hypertension. One of the main implications is that ketone-body formation and associated vascular deposition in diabetic
aortas could potentially be a localized event. The identification of key molecules involved can be used to target them phar-
macologically in future studies specifically, which will also address the transferability of the results to the human condition.
 Proteome-Based Systems Biology Analysis of the Diabetic Mouse Aorta Reveals Major
Changes in Fatty Acid Biosynthesis as Potential Hallmark in Diabetes Mellitus−Associated
Vascular Disease
Holger Husi, Tom Van Agtmael, William Mullen, Ferdinand H. Bahlmann, Joost P. Schanstra,
Antonia Vlahou, Christian Delles, Paul Perco and Harald Mischak
Downloaded from http://circgenetics.ahajournals.org/ by guest on November 12, 2017

Circ Cardiovasc Genet. 2014;7:161-170; originally published online February 26, 2014;
doi: 10.1161/CIRCGENETICS.113.000196
Circulation: Cardiovascular Genetics is published by the American Heart Association, 7272 Greenville Avenue,
Dallas, TX 75231
Copyright © 2014 American Heart Association, Inc. All rights reserved.
Print ISSN: 1942-325X. Online ISSN: 1942-3268

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SUPPLEMENTAL MATERIAL

Index of Supplementary information page

1. Supplementary methodological information

- Sample preparation 3

- Mass spectrometry analysis 3

- Protein sequence database searching 4

- Immunohistochemistry quantification 5

2. Supplementary Table S1. Merged datasets of proteins 6

identified in this study and cross-IDs to other databases.

3. Supplementary Table S2. List of the statistically most 183

significant proteins modulated in aortas of diabetic mice.

Proteins which showed both a high statistical significance

(p<0.05) and fold-changes of at least 1.4 in aorta-samples

from STZ-treated and untreated mice are listed. Fold changes

are the ratio of average ion counts per group. Fold changes of

1000 (STZ treated only) or 0.001 (control only) denote where

a protein was only found in one group. Functional

classification and compartment localization was based on the

PADB functional classification system and SwissProt

keyword tags.

4. Supplementary Table S3. Human disease analysis using 189

OMIM database mining. Statistically significant molecules

were used for OMIM database mining. The descriptive terms

-1-
 from the OMIM database as well as the associated gene

names are shown.

5. Supplementary Table S4. Descriptive analysis of molecules 190

regulated in diabetic aortas of STZ-treated mice.

6. Supplementary Figure S1. Cluster analysis using GO 215

annotations. Statistically significant protein entries were

analyzed using the Cytoscape ClueGO plug-in with a two-

sided hypergeometric test for enrichment and depletion and

Bonferroni correction. Associated genes are shown. Red: up-

regulated, green: down-regulated.

7. Supplementary Figure S2. Interactome-cluster analysis. 216

Protein interaction networks were generated with dataset 1

(A) (red, up-regulated proteins in diabetes, p<0.05) and

dataset 2 (B) (green, down-regulated proteins in diabetes,

p<0.05) using all protein entries with p<0.1 (marked grey).

All entries were annotated with their respective gene names in

order to enable searching.

8. Supplementary Figure S3. Metabolic pathway analysis of 217

the STZ-induced diabetic condition in mouse. The full

metabolic pathways include gluconeogenesis/glycolysis, fatty

acid metabolism, pyruvate pathway, TCA cycle, amino acid

metabolism and inter-linking pathways. Signaling pathways

are linked to insulin-dependent signaling cascades.

-2-
Supplementary Methods

Sample preparation.

Tissues were blended with an Ultra-Turrax T 25 (IKA, Staufen, Germany) and

homogenised in SDS-lysis buffer, incubated at 95ºC for 3 minutes and placed in an

ultrasonic bath for 30 minutes. An aliquot of the homogenate was taken and placed in

a Micron YM-30 filter device (Millipore, Watford UK). Twice, 8 M Urea buffer (UA)

was added to the homogenate and centrifuged at 14,000 g for 15 minutes. The retenate

was mixed for 1 minute with 0.05 M iodoacetamide buffer (IAA) and incubated for

20 minutes. UA buffer was added and centrifuged (twice). Ammonium bicarbonate

buffer (ABC) was added and centrifuged (twice) before incubating overnight with

trypsin. The digest was centrifuged and washed with ABC buffer prior to acidification

with formic acid (0.1%). Sample volumes were adjusted to match final concentration

of protein prior to analysis by LC-MS/MS.

Mass spectrometry analysis.

Tissue extracts were separated on a Dionex Ultimate 3000 RSLS nano-flow system

(Dionex, Camberly UK). A 5 µl sample was loaded in 0.1% formic acid and

acetonitrile (98:2) onto a Dionex 100 µm x 2 cm, 5 µm C18 nano-trap column at a

flowrate of 5µl/min. Elution was performed on an Acclaim PepMap C18 nano-

column 75 μm x 50 cm, 2 μm, 100 Å with a linear gradient of 0.1% formic acid and

acetonitrile (98:2) against solvent B, 0.1% formic acid and acetonitrile (20:80),

starting at 1% B for 5 minutes rising to 30% at 400 minutes then to 50%B at 480

minutes. The sample was ionized in positive ion mode using a Proxeon nano-spray

ESI source (Thermo Fisher Hemel UK) and analyzed using an Orbitrap-Velos

-3-
Fourier-transform mass spectrometer (Thermo-Finnigan, Bremen, Germany). Mass

spectra were acquired in a data-dependent mode (top 40) to switch between MS and

MS/MS acquisition. Parent ions were fragmented by collision-induced dissociation

(CID).

Protein sequence database searching.

Mass spectra were analyzed using the SEQUEST module of Proteome Discoverer

(Thermo Fisher Hemel UK) and the mouse IPI sequence database (version 3.67). The

false discovery rate for sequence searching was calculated automatically using the

reference as well as the decoy databases. There are at least two ways to use the

"Decoy" hits to calculate the False Discovery: the global FDR estimates the error rate

of the whole set of proteins defined by a threshold value 1. That is, the global FDR

tells the likely error rate of the entire set of identifications with scores as good as or

better than the threshold set and uses the formula [100*(2*number of Decoy Database

IDs)/Total IDs] to define the FDR at any cut-off score chosen. For example, if one

had a list of 600 identified proteins with an search engine specific scores ranging from

137 down to 15, and this list contained 18 "IDs" from the Decoy database search, then

the FDR estimate using the Global method for the set of IDs with scores of 15 or

higher would be 100*(2*18)/600 = 6% This FDR of 6% applies to the whole set on

average. With top scoring items having an FDR<6% and low scoring ones with

FDR>6%.These shortcomings lead to the introduction of the local FDR, that estimates

the local error rate around a given identification, which indicates the likelihood that

that the specific identification is incorrect 2. We have used the global FDR estimate of

0.38% in our analysis.

-4-
Immunohistochemistry quantification.

Immunohistochemistry staining images were recorded using the blue channel for

nuclear stain and the red channel for the specific stain (Zeiss LSM software; Zeiss,

Germany). In ImageJ (version 1.47v), random areas were selected and the area split

into its three color-components (red, blue, green) and quantified based on the

transformed greyscale image. The intensity ratio for each section was calculated by

dividing the value from the red channel by the value from the blue channel, with the

exception of the Oil red O staining, where the red channel value was divided by the

sum of the blue and green channel values. These ratios (9 measurements per stain per

condition) were then used to calculate the statistical significance using a

heteroscedastic, unpaired Student’s t-test, the mean value and the standard error of the

mean.

Reference List

(1) Elias JE, Haas W, Faherty BK, Gygi SP. Comparative evaluation of mass
spectrometry platforms used in large-scale proteomics investigations. Nat
Methods 2005;2:667-675.

(2) Tang WH, Shilov IV, Seymour SL. Nonlinear fitting method for determining
local false discovery rates from decoy database searches. J Proteome Res
2008;7:3661-3667.

-5-
Supplementary Table S1. Merged datasets of proteins identified in this study and cross-IDs to other databases.

protein gene PADB- sub-tag role in Protein- SwissProt UniProt ENSEMB ENTREZ p-value fold- total control control control control control STZ STZ STZ STZ STZ
name name KW diabetes IPI.versio ID accession L change peptide 1 2 3 4 5 diabetic diabetic diabetic diabetic diabetic
n number count 1 2 3 4 5
ATP-citrate Acly ENZ lipid IPI001262 ACLY_M Q3UEA1| ENSMUS 104112 0.00336 0.08 34 2659.54 1956.25 1332.99 731.802 2179.71 0 0 156.647 0 140.920
synthase synthesis, 48.3/IPI00 OUSE Q99K05 G0000002 9995 9444 88 181 7612 5405 6186 4873
apoptosis 762047.1 0917
Tricarboxyl Slc25a1 TP mitocho regulation IPI002769 Q8JZU2_ Q3TDH6 ENSMUS 13358 0.00749 0.00 3 242.616 393.613 238.821 238.178 285.452 0 0 0 0 0
ate ndria of insulin 26.3 MOUSE G0000000 4958 7719 5202 5076 5553 9049
transport secretion 3528
protein,
mitochondr
ial
Isoform 3 Crip3 UK unknown IPI001261 CRIP3_M Q6Q6R3 ENSMUS 114570 0.00749 1000.00 1 0 0 0 0 0 310.534 180.191 84.8136 46.4881 783.023
of 13.1 OUSE G0000002 4958 4418 0263 1913 5588 3674
Cysteine- 3968
rich protein
3
Fatty acid Fasn ENZ mitocho fatty acid IPI001132 FAS_MO Q3UHT6 ENSMUS 14104 0.00793 0.05 56 24767.0 17743.7 10504.4 6327.75 12081.5 610.170 199.829 668.621 1639.70 122.818
synthase ndria metabolis 23.2 USE G0000002 6508 8596 7591 1314 4766 8321 2397 477 8973 7264 5633
m 5153
pyruvate Pc ENZ mitocho glycolysis, IPI001147 PYC_MO Q8BP54 0.00793 0.36 24 2045.28 2303.57 1522.33 1181.68 1741.99 488.350 235.579 685.719 1096.24 647.586
carboxylase ndria fatty acid 10.4 USE 6508 289 716 3804 8089 4259 2136 0399 0432 7633 2836
, metabolis
mitochondr m
ial isoform
2
Isocitrate Idh2 ENZ mitocho glycolysis IPI003186 IDHP_M P54071 ENSMUS 269951 0.00793 2.22 14 600.699 558.163 630.014 659.075 213.195 1508.13 795.685 1331.43 1054.42 1209.73
dehydrogen ndria 14.9 OUSE G0000003 6508 3591 6824 8968 4027 7371 9771 7816 1457 4607 2462
ase 0541
[NADP],
mitochondr
ial
Leucine- Lrpprc TF mitocho Apoptosis IPI004207 LPPRC_ Q6PB66 ENSMUS 72416 0.00793 0.52 8 751.602 819.150 1116.04 1103.98 834.659 283.254 144.901 749.728 697.278 545.983
rich PPR ndria 06.4 MOUSE G0000002 6508 4225 8039 6865 2996 1646 8215 2963 3629 1038 0738
motif- 4120
containing
protein,
mitochondr
ial
Transgelin Tagln CS muscle vascularis IPI002265 TAGL_M P37804 ENSMUS 21345 0.00793 0.41 11 1819.47 1680.63 3297.37 2861.05 2586.19 552.726 376.672 1660.52 1509.17 877.505
ation, 15.5 OUSE G0000003 6508 3087 3428 1172 7638 3916 1271 2807 9039 8079 958
apoptosis 2085
mediator
Transketola Tkt ENZ glycolysis IPI001374 TKT_MO O55021 ENSMUS 21881 0.00793 0.31 20 5526.36 5731.15 3992.30 4230.40 3111.22 778.237 415.575 2067.56 2700.10 1021.88
se 09.3 USE G0000002 6508 3047 5044 4772 2142 3397 0276 3908 1559 5313 2066
1957
Liver Ces1c ENZ fatty acid IPI001383 EST1C_ P23953 ENSMUS 13884 0.00793 0.55 7 551.113 877.019 616.170 703.696 621.451 301.990 357.119 396.158 418.468 393.238
carboxylest metabolis 42.4 MOUSE G0000005 6508 3533 6569 9062 7672 1158 5812 1328 089 2788 7978
erase N m, 7400
transcripti
onal
repressor
of growth
hormone

-6-
 receptor
expression
, might be
involved
in
hypertensi
on
(protectiv
e, by
activating
an
angiotensi
n-
converting
enzyme
inhibitor)
Serine/thre Ankrd4 MOD apoptosis IPI007557 ANR44_ E9QNQ2 ENSMUS 329154 0.00793 0.64 1 414.727 261.284 224.415 249.713 248.446 192.142 128.093 209.985 205.542 162.944
onine- 4 96.2 MOUSE G0000005 6508 7917 6499 6725 2346 0519 4845 3501 9995 4735 4995
protein 2331
phosphatas
e6
regulatory
ankyrin
repeat
subunit B
Alpha- Eno1 ENZ glycolysis, IPI004732 ENOA_M Q8CF78/P ENSMUS 13806 0.01051 0.68 29 5496.39 5112.41 3719.29 3449.09 4253.67 3137.41 2036.26 3042.59 3651.67 3140.45
enolase plays a 27.1/IPI00 OUSE 17182 G0000005 2561 3173 3383 3642 3 9702 387 3016 9519 8176 8563
part in 462072.3 9040|ENS
various MUSG00
processes 00006352
such as 4
growth
control,
hypoxia
tolerance
and
allergic
responses
Transmemb Tmem2 TM unknown IPI008304 T229A_M B9EJI9 ENSMUS 319832 0.01115 5.12 1 78.7867 0 70.9987 0 0 98.0917 121.959 172.884 203.571 170.163
rane protein 29a 92.1 OUSE G0000004 9425 5642 8323 5398 6415 0877 4447 4926
229A 8022
Alpha-1- Serpina INH secreted protease IPI001239 A1AT5_ Q00898 ENSMUS 20704 0.01192 0.32 9 3543.31 4293.26 3007.56 3779.11 3372.58 1391.41 0 0 2549.86 1859.04
antitrypsin 1e inhibitor 27.1 MOUSE G0000007 5234 5584 9689 7082 0197 559 5864 481 2458
1-5 2849
6- Pgd ENZ carbohydr IPI004669 6PGD_M A2AH73 ENSMUS 110208 0.01192 0.06 8 514.735 721.560 381.572 304.198 588.411 25.7001 0 36.9606 97.8376 0
phosphoglu ate 19.7 OUSE G0000002 5234 4611 5172 2528 6312 1139 8613 1077 398
conate degradatio 8961
dehydrogen n, PPP
ase, pathway
decarboxyl
ating
Perilipin-1 Plin1 MOD fatty acid IPI002237 PLIN1_M Q8CGN5 ENSMUS 103968 0.01366 0.40 32 2669.68 1469.03 2097.76 1352.83 905.971 698.589 292.670 944.499 1234.38 214.722
storage 83.2/IPI00 OUSE G0000003 2463 6822 263 7851 2721 8781 8998 0104 5574 9369 4155
947617.1/ 0546
IPI009476
05.1
Fatty acid- Fabp4 TP lipid IPI001167 FABP4_ Q542H7 ENSMUS 11770 0.01587 0.51 8 5401.91 6309.58 5834.34 3741.84 5757.47 2898.52 877.834 4496.17 3610.04 1992.97

-7-
binding transporte 05.5 MOUSE G0000006 3016 0144 0904 6929 9979 4979 5458 7805 0928 8403 6516
protein, r, nitric 2515
adipocyte oxide
pathway,
stroke,
vasular
inflammat
ion,
diabetes
Cysteine Csrp1 CS vascularis IPI001238 CSRP1_ Q4FJX4 ENSMUS 13007 0.01587 0.43 6 343.926 245.239 473.837 503.662 807.266 221.966 85.3300 312.434 189.648 199.830
and ation 91.3 MOUSE G0000002 3016 6915 6356 4232 682 3818 3794 1048 1973 3287 4438
glycine-rich 6421
protein 1
14-3-3 Ywhag SCA oxidative IPI002307 1433G_M P61982 ENSMUS 22628 0.01587 0.69 10 1336.64 1433.01 1489.29 1531.51 1564.18 870.146 306.262 1204.27 1401.86 1275.71
protein stress 07.6 OUSE G0000005 3016 6095 9645 946 7436 9477 7337 9366 5176 8087 8273
gamma 1391
Filamin-A Flna CS hypertensi IPI006646 FLNA_M Q4FZG4/ ENSMUS 192176 0.01910 0.58 97 5248.98 4338.87 7146.41 4106.97 4147.19 1906.83 1627.53 4609.48 4200.74 2052.78
on, actin 43.3/IPI00 OUSE Q6KAM8 G0000003 9248 3694 2374 0926 0702 3609 4391 9456 8862 5566 1084
remodelli 875567.1 1328
ng, insulin
pathway
14-3-3 Ywhae SCA oxidative IPI008282 1433E_M F6WA09/ ENSMUS 22627 0.01944 0.67 10 973.124 1468.00 785.191 825.963 989.329 526.274 0 791.361 728.336 671.023
protein stress 66.2/IPI00 OUSE P62259 G0000002 5554 9364 9069 8125 4873 1932 5913 9754 7221 6805
epsilon 118384.1 0849
Negative Cobra1 TF ubiquitiny IPI009229 NELFB_ B7ZCG0/ ENSMUS 58202 0.01952 0.19 4 1328.14 1686.75 0 770.193 1156.21 0 191.836 26.6110 472.077 0
elongation lation 88.2/IPI00 MOUSE Q69ZP4 G0000001 7967 8872 8584 5057 8449 634 6167 3839
factor B 890333.2 3465
Fatty acid- Fabp3 TP apoptosis IPI002301 FABPH_ Q5EBJ0 ENSMUS 14077 0.02000 5.12 4 211.096 64.8783 0 0 0 267.590 163.359 243.549 219.089 519.936
binding 24.5 MOUSE G0000002 8185 0723 7389 8402 7862 3959 0669 6653
protein, 8773
heart
Alpha-1- Serpina INH secreted defective IPI009698 A1AT2_ Q3KQQ4/ ENSMUS 20701 0.02086 0.68 29 10580.3 14102.7 8996.75 10047.3 10469.3 5695.69 3939.91 8483.78 10316.8 8345.12
antitrypsin 1b epidermal 67.1/IPI00 MOUSE Q91X22/P G0000007 6544 7486 0932 6436 6303 9294 7655 0859 4014 2322 7449
1-2 barrier 475157.1/ 22599 1178
IPI001297
55.2
F-box only Fbxo9 MOD act as IPI009707 FBX9_M E0CYX8/ ENSMUS 71538 0.02501 0.48 3 397.387 399.938 492.437 0 264.051 189.398 0 180.788 0 0
protein 9 protein- 95.1/IPI00 OUSE Q8BK06 G0000000 4904 1801 2459 1075 5456 686 8406
ubiquitin 311910.4 1366
ligases
6.8 kDa Mp68 ENZ mitocho unknown IPI001131 68MP_M P56379 ENSMUS 70257 0.02536 1000.00 1 0 0 0 0 0 86.7437 57.6694 92.2555 0 161.216
mitochondr ndria 43.1 OUSE G0000002 986 592 816 4858 792
ial 1290
proteolipid
myomesin Myom2 TP muscle cardiomyo IPI001158 Q14BI5_ Q3UQS9 ENSMUS 17930 0.02536 1000.00 8 0 0 0 0 0 4774.55 0 8386.65 6105.40 9422.47
2 pathy 23.2 MOUSE G0000003 986 5255 0363 3241 689
1461
Sarcoplasm Atp2a1 ENZ muscle type2 IPI003116 AT2A1_ Q3V1C4 ENSMUS 11937 0.02536 1000.00 19 0 0 0 0 0 2490.10 856.730 222.254 0 3711.47
ic/endoplas diabetes 54.4 MOUSE G0000003 986 4192 6022 2531 1254
mic associated 0730
reticulum
calcium
ATPase 1
Isoform 1 Hsd17b ENZ regulation IPI001192 DHB12_ Q0VGQ1 ENSMUS 56348 0.02536 0.00 5 242.057 246.750 197.297 70.2278 0 0 0 0 0 0
of Estradiol 12 of fatty 19.2 MOUSE G0000002 986 8592 9091 7316 7771
17-beta- acid 7195

-8-
dehydrogen synthesis
ase 12
Glycogen Gsk3b ENZ hypertrop IPI001253 GSK3B_ Q5KU03 ENSMUS 56637 0.02536 0.00 1 430.258 311.531 553.651 0 309.571 0 0 0 0 0
synthase hy, 19.1 MOUSE G0000002 986 6612 6159 5213 5909
kinase-3 negative 2812
beta regulator
in the
hormonal
control of
glucose
homeostas
is,
Probably
regulates
NF-
kappa-B
(NFKB1)
at the
transcripti
onal level
and is
required
for the
NF-
kappa-B-
mediated
anti-
apoptotic
response
to TNF-
alpha
(TNF/TN
FA).
RNA Rrn3 TF cell IPI001274 RRN3_M B2RS91 ENSMUS 106298 0.02536 1000.00 2 0 0 0 0 0 401.641 239.611 67.3061 0 675.158
polymerase growth 54.5 OUSE G0000002 986 7942 7142 6982 0965
I-specific 2682
transcriptio
n initiation
factor
RRN3
Mps one Mob3a MOD unknown IPI002248 MOB3A_ Q8BSU7 ENSMUS 208228 0.02536 1000.00 1 0 0 0 0 0 98.0917 93.8391 172.884 0 170.163
binder 15.1 MOUSE G0000000 986 5398 4413 0877 4926
kinase 3348
activator-
like 2A
Aspartate Got1 ENZ fatty acid IPI002302 AATC_M P05201 ENSMUS 14718 0.02536 1000.00 13 0 0 0 0 0 415.345 240.323 153.636 0 1099.21
aminotransf homeostas 04.8 OUSE G0000002 986 6511 6795 3601 0374
erase, is by 5190
cytoplasmic promoting
glycerol
3-
phosphate
formation
Cartilage Crtac1 CS unknown IPI003306 CRAC1_ Q8R555 ENSMUS 72832 0.02536 1000.00 3 0 0 0 0 0 165.728 80.5370 0 109.764 149.311
acidic 53.2 MOUSE G0000004 986 7453 6123 229 5624
protein 1 2401
Histone Hist2h2 TF PARP IPI003482 H2B2B_ Q64525 ENSMUS 319189 0.02536 0.00 6 0 2243.68 2926.79 6883.43 8092.57 0 0 0 0 0

-9-
H2B type bb pathway 70.3 MOUSE G0000005 986 9474 541 8605 9894
2-B 0936
Putative D03004 UK unknown IPI004640 Q3UR76_ Q3UR76 0.02536 1000.00 1 0 0 0 0 0 712.437 527.426 0 1307.57 1832.74
uncharacter 6N08Ri 66.2 MOUSE 986 3975 9761 2246 695
ized protein k
Isoform 1 Acaca ENZ fatty acid IPI004747 ACACA_ Q9ESZ5 ENSMUS 107476 0.02536 0.00 27 1956.53 903.334 439.979 0 421.351 0 0 0 0 0
of Acetyl- metabolis 83.4 MOUSE G0000002 986 1801 8607 5686 1292
CoA m, PPAR 0532
carboxylase pathway
1
UPF0308 C9orf21 UK ubiquitin- IPI006540 CI021_M E9QAE9 ENSMUS 66129 0.02536 1000.00 1 0 0 0 0 0 141.242 133.240 0 32.2078 541.188
protein mediated 64.2 OUSE G0000002 986 2841 3271 4117 7065
C9orf21 proteolysi 1482
homolog s
(PMID:19
322201)
Protein Vmn2r6 RCP apoptosis IPI006749 E9Q4U2_ E9Q4U2 ENSMUS 637873 0.02536 1000.00 1 0 0 0 0 0 157.503 0 195.974 127.412 240.650
Vmn2r61, 1 75.2 MOUSE G0000009 986 9829 3305 6916 7882
vomeronasa 0967
l receptor,
Calcium-
sensing
receptor
related
protein
14-3-3 Ywhab SCA oxidative IPI007507 1433B_M A2A5N1/ ENSMUS 54401 0.02817 0.64 14 1057.20 1080.84 1164.50 1079.40 1211.62 659.854 148.111 886.433 964.560 928.584
protein stress 90.1/IPI00 OUSE Q9CQV8 G0000001 1108 0038 5479 2669 8135 4657 4991 3581 7937 2886 9
beta/alpha 760000.1 8326
Solute Slc25a4 TP mitocho transporte IPI004029 S2544_M Q8BGF9 229517 0.03174 0.49 1 143.267 114.372 304.978 114.583 173.167 78.9178 44.7103 122.889 108.982 63.5686
carrier 4 ndria r with 10.5 OUSE 6032 6374 4436 7001 105 3949 473 1079 7949 2796 436
family 25 unknown
member 44 function
Myoglobin Mb TP muscle oxidative IPI002307 MYG_M Q3UVB1 ENSMUS 17189 0.03174 5.85 7 101.137 490.850 582.827 88.6817 101.062 1894.00 1173.06 807.833 351.712 3759.67
stress 60.5 OUSE G0000001 6032 5544 7763 4902 6749 5896 803 3352 1534 2088 196
8893
Murinoglob Mug1 INH secreted oxidative IPI001232 MUG1_M P28665 ENSMUS 17836 0.03174 0.59 21 1748.76 1971.84 996.527 1385.78 1275.87 948.669 454.197 1099.01 1097.23 778.657
ulin-1 stress 23.2 OUSE G0000005 6032 6788 1055 325 3848 0921 7326 1344 8421 6182 5691
9908
Hemopexin Hpx TP secreted oxidative IPI001284 HEMO_ Q91X72 ENSMUS 15458 0.03174 0.54 10 983.779 1424.87 774.904 692.338 1821.25 708.944 330.854 611.449 751.560 691.213
stress, 84.2 MOUSE G0000003 6032 5606 3838 81 5219 6995 0537 2545 0007 0562 939
acute 0895
inflammat
ion
apolipoprot Apoa1 TP secreted hypertensi IPI008772 APOA1_ O08855 0.03174 0.61 16 4106.84 3567.56 2650.32 5626.38 3908.64 2006.32 1745.77 3082.08 3109.66 2116.32
ein A-I on, fatty 36.1 MOUSE 6032 4502 7319 2893 0555 1998 0316 5635 2569 2244 6952
preproprote acid
in transport
T-complex Cct6a CHA proteasom IPI001162 TCPZ_M Q3TI05 12466 0.03174 0.54 6 324.549 465.314 301.476 511.176 218.986 185.546 97.1992 252.063 192.040 257.888
protein 1 e, 81.3 OUSE 6032 0779 3326 8721 243 2145 4981 6235 1901 4368 235
subunit zeta ubiquitin-
mediated
apoptosis
14-3-3 Ywhaz SCA oxidative IPI001164 1433Z_M Q3UA58 ENSMUS 22631 0.03174 0.67 7 1054.52 924.696 1017.96 927.801 1337.60 648.268 134.602 909.223 909.328 943.672
protein stress 98.1 OUSE G0000002 6032 0772 6803 3009 8883 0496 9106 7239 5337 237 312
zeta/delta 2285
Transaldola Taldo1 ENZ pentose IPI001246 TALDO_ Q93092 ENSMUS 21351 0.03174 0.56 15 1337.38 1251.44 967.205 737.579 916.477 399.459 298.617 909.109 903.091 421.301

- 10 -
se phosphate 92.1 MOUSE G0000002 6032 9168 7649 6982 5537 7386 0852 5836 6905 6304 5449
pathway 5503
of glucose
metabolis
m
Isoform 5b Prph CS neurogene IPI002304 PERI_MO P15331 0.03174 0.68 15 1628.54 1410.02 1586.85 1519.82 1434.27 730.507 379.894 1266.08 1452.68 1312.35
of sis 45.1 USE 6032 583 9623 3389 9393 2427 1804 9897 273 425 6464
Peripherin
Elongation Eef1a1 TF cell IPI003078 EF1A1_M Q3UA81 ENSMUS 13627 0.03174 0.58 13 3896.84 3654.40 2981.02 5934.00 3258.91 1988.07 912.224 3159.69 3257.86 2120.23
factor 1- proliferati 37.6 OUSE G0000003 6032 1437 7325 5959 937 7232 7734 6079 443 4773 2134
alpha 1 on, 7742
TGFbeta
pathway,
actin
cytoskelet
al re-
modelling
Platelet Cd36 TP Binds IPI003312 CD36_M Q3TA14 ENSMUS 12491 0.03174 0.64 3 745.442 735.614 540.055 560.372 793.783 445.841 160.008 682.889 502.535 367.225
glycoprotei long chain 14.5 OUSE G0000000 6032 4547 0724 8099 9433 8723 9776 1374 095 9868 7539
n4 fatty acids 2944
and may
function
in the
transport
and/or as
a regulator
of fatty
acid
transport
Chromoso Champ1 TF cell IPI004538 CHAP1_ Q8K327 ENSMUS 101994 0.03174 0.39 3 415.283 452.595 600.203 580.045 901.907 17.1511 166.721 506.503 131.703 321.859
me growth 00.4 MOUSE G0000004 6032 65 6167 7618 1845 7367 446 198 8307 8895 7088
alignment- 7710
maintaining
phosphopro
tein 1
Glycerol-3- Gpd1 ENZ glycolysis IPI009700 GPDA_M E0CXN5 ENSMUS 14555 0.03174 0.46 15 4756.23 5386.80 3661.77 4302.64 2426.74 2014.74 1013.95 2704.90 2949.56 848.161
phosphate 97.1 OUSE G0000002 6032 5316 0349 2941 2076 2276 772 9805 4228 3154 5377
dehydrogen 3019
ase
[NAD(+)],
cytoplasmic
Myosin-2 Myh2 CS muscle myogenes IPI009863 Q5SX41_ Q1WNQ9 ENSMUS 0.03272 7.50 136 0 4887.46 1704.88 0 382.791 19112.0 24392.2 4772.85 2174.70 36765.6
is 64.1/IPI00 MOUSE /Q5SX41 G0000003 7548 8918 2069 1834 2136 7538 4548 0893 2663
649292.2/ 3196
IPI010274
46.1
Myosin-1 Myh1 TP muscle myogenes IPI003808 MYH1_M Q5SX40 ENSMUS 17879 0.03445 12.34 81 0 4920.26 1577.44 0 0 19722.6 12905.9 4727.25 1917.93 40908.8
is 96.1 OUSE G0000005 3637 258 5329 4768 7678 1476 1484 1933
6328
Myosin-4 Myh4 TP muscle myogenes IPI004048 MYH4_M Q9JHR4 ENSMUS 17884 0.03445 13.68 80 0 3964.72 1644.31 0 0 21428.8 12188.1 4091.80 1597.42 37439.8
is 37.3 OUSE G0000005 3637 4246 0836 9735 1006 359 7178 0174
7003
Protein S100a6 SIG hypertensi IPI001214 S10A6_M P14069 ENSMUS 20200 0.03445 0.28 2 236.934 220.397 350.362 327.121 141.126 0 0 189.793 0 172.254
S100-A6 on, 27.1 OUSE G0000000 3637 509 1609 3288 035 3799 5379 4261
cytoskelet 1025
al
Myosin-11 Myh11 CS muscle aortic IPI009385 MYH11_ E9QPE7/ ENSMUS 0.04282 0.47 181 8319.28 11432.8 20232.4 7712.08 6084.83 6091.91 3559.48 6881.21 6221.06 2435.69

- 11 -
 aneurysms 30.1/IPI00 MOUSE O08638 G0000001 9492 6727 3504 7799 6739 0862 1196 0641 3939 9926 885
, 227865.1/ 8830
vascularis IPI001148
ation, 94.1
TGFbeta
signalling
pathway
Myosin-8 Myh8 CS muscle myogenes IPI002653 MYH8_M B2RWW8 ENSMUS 17885 0.04341 6.26 53 398.585 3280.73 0 0 0 14682.5 9822.88 3436.76 1464.91 28211.4
is 80.4/IPI00 OUSE /Q61933 G0000005 5396 0848 7171 063 9934 896 7869 0301
474410.1 5775
Fibrous Fsip2 CS mitocho unknown IPI007500 FSIP2_M Q8R4I8 ENSMUS 0.04490 0.05 5 603.841 377.619 353.475 0 375.337 0 90.0453 0 0 0
sheath- ndria 14.6 OUSE G0000007 859 2029 1002 7895 4496 3733
interacting 5249
protein 2
Myosin Myl3 TP muscle hypertensi IPI001333 MYL3_M Q61935 ENSMUS 17897 0.04490 11.88 7 0 0 0 314.791 0 827.177 636.256 364.647 0 1911.95
light chain on, 92.3 OUSE G0000005 859 9175 4715 2462 584 9989
3 serotonin 9741
modulated
,
myogenes
is
alpha- Actn2 CS muscle hypertensi IPI003875 ACTN2_ Q8K3Q4 11472 0.04490 34.30 24 0 146.814 0 0 0 1171.31 870.590 280.042 0 2714.12
actinin-2 on 57.3 MOUSE 859 3561 5798 693 7478 7689
Myh13 Myh13 TP muscle myogenes IPI004686 B1AR69_ Q9Z2B8 ENSMUS 544791 0.04490 16.77 28 0 0 1578.63 0 0 7388.68 3585.75 1859.03 0 13647.8
is 65.2 MOUSE G0000006 859 1004 6616 2151 5519 0688
0180
Histone Hist1h2 TF PARP IPI001146 H2B1F_ P10853 ENSMUS 319180 0.04490 6.65 6 1570.58 0 0 0 0 1624.06 0 2434.15 2711.59 3680.19
H2B type bf pathway 42.4 MOUSE G0000006 859 4743 7875 1972 3886 9035
1-F/J/L 9271|ENS
MUSG00
00006931
4|ENSMU
SG000000
69268|EN
SMUSG0
00000693
00|ENSM
USG0000
0069303|E
NSMUSG
00000069
307
Gasdermin- Gsdmc2 DEV apoptosis IPI004037 GSDC2_ Q2KHK6 ENSMUS 331063 0.04490 0.11 2 206.680 172.715 187.972 0 132.758 79.3389 0 0 0 0
C2 09.4 MOUSE G0000005 859 4252 9048 4873 0512 9741
6293
Lysine- Kdm4c ENZ PPARgam IPI004700 KDM4C_ Q3UMI0 ENSMUS 76804 0.04490 0.03 2 510.554 857.377 353.981 1171.21 0 0 97.3604 0 0 0
specific ma 06.2 MOUSE G0000002 859 4623 087 3829 5468 3291
demethylas signalling 8397
e 4C
aminopepti Aqpep ENZ unknown IPI006748 AMPQ_M E9QJR0 ENSMUS 0.04490 0.03 1 339.419 434.404 353.981 341.998 0 0 47.7415 0 0 0
dase Q 77.1 OUSE G0000002 859 6384 7546 3829 6127 9314
4481
SAM Samd15 UK unknown IPI009880 SAM15_ F6XZJ7 238333 0.04490 59.93 4 0 0 0 0 25.1298 266.647 0 281.533 829.299 128.561
domain- 33.1 MOUSE 859 6639 8232 9591 2785 9177
containing
protein
C14orf174

- 12 -
Myosin Myl2 TP muscle up- IPI008571 MLRV_M D3YUI7/ ENSMUS 17906 0.04536 1000.00 10 0 0 0 0 0 152.014 290.056 0 0 329.467
regulatory regulated 04.1/IPI00 OUSE P51667 G0000001 8931 5832 5279 8372
light chain in diabetes 555015.3 3936
2,
ventricular/
cardiac
muscle
isoform
Alpha- Cryab DEV hypertrop IPI009746 CRYAB_ F8WJ07/P ENSMUS 12955 0.04607 7.37 6 0 0 31.5842 0 0 214.241 179.642 0 0 304.210
crystallin B hy 11.1/IPI00 MOUSE 23927 G0000003 9622 9179 5772 007 3514
chain 138274.1 2060
Microtubul Mast2 ENZ Regulates IPI006495 MAST2_ B1AST6/ ENSMUS 17776 0.04818 1000.00 3 0 0 0 0 0 63.0982 67.2570 0 0 125.711
e- lipopolysa 47.1/IPI00 MOUSE E9QLW6 G0000000 9262 4298 573 4461
associated ccharide- 118134.4 3810
serine/threo induced
nine- IL-12
protein synthesis
kinase 2 in
macropha
ges by
forming a
complex
with
TRAF6,
resulting
in the
inhibition
of TRAF6
NF-
kappa-B
activation.
Aldose Akr1b1 ENZ oxidative IPI007549 ALDR_M D3YVJ7/ ENSMUS 11677 0.04958 3.06 10 0 0 0 0 106.528 348.783 0 265.729 0 362.048
reductase stress 43.1/IPI00 OUSE P45376 G0000000 2714 5719 4188 1907 5577
223757.4 1642
Isoform 1 Sart3 TF IPI004588 SART3_ Q9JLI8 ENSMUS 53890 0.05241 4.04 3 0 0 0 0 133.008 63.1637 59.9622 98.9514 176.977 138.260
of 54.2 MOUSE G0000001 1629 377 4636 4886 2516 3196 0243
Squamous 8974
cell
carcinoma
antigen
recognized
by T-cells 3
PDZ and Pdlim5 SCA IPI009881 PDLI5_M D9J2Z9/Q ENSMUS 56376 0.05341 1000.00 7 0 0 0 0 0 165.020 55.1837 0 0 157.529
LIM 07.1/IPI00 OUSE 9CRA2 G0000002 8741 5871 4252 7861
domain 467374.1 8273
protein 5
Ras-related Rab11b TP IPI010266 RB11B_ G3UY29/ ENSMUS 19326 0.05354 0.00 5 62.8666 114.845 0 0 44.9639 0 0 0 0 0
protein 98.1/IPI01 MOUSE G3UZL4 G0000007 0123 0817 3509 8349
Rab-11B 026780.1 7450
LIM Ldb3 CS muscle IPI006561 LDB3_M Q9JKS4 ENSMUS 24131 0.05377 1000.00 8 0 0 0 0 0 154.919 227.049 0 0 406.068
domain- 73.1/IPI00 OUSE G0000002 7621 2645 9099 1757
binding 625287.2 1798
protein 3
Collagen Col1a2 CS secreted IPI009881 CO1A2_ Q91VL4/ ENSMUS 12843 0.05393 0.62 62 7062.24 5100.48 5581.62 5351.24 4492.99 1682.94 723.236 3893.22 6101.31 4813.40
alpha-2(I) 09.1/IPI00 MOUSE Q01149 G0000002 6832 2199 9181 0325 5789 4242 3792 5214 4292 6984 2491
chain 222188.4 9661
Hexokinase Hk2 ENZ IPI009894 HXK2_M E9Q5B5/ ENSMUS 15277 0.05470 0.29 10 230.992 161.491 125.612 0 0 50.6258 0 0 0 0

- 13 -
-2 51.1/IPI00 OUSE O08528 G0000000 1406 5016 7784 4978 9411
114342.1 0628
Leucine- Lrriq1 UK IPI009440 LRIQ1_M Q0P5X1 ENSMUS 74978 0.05475 0.93 4 171.134 100.096 129.196 299.517 0 0 162.143 0 0 0
rich repeat 96.1/IPI00 OUSE G0000001 9142 8239 6481 8159 3728 7202
and IQ 944193.1 9892
domain-
containing
protein 1
Pyruvate Pdhb ENZ mitocho IPI001320 ODPB_M Q9D051 ENSMUS 68263 0.05555 0.51 4 1411.52 2170.62 1294.35 1472.06 706.100 477.759 322.274 812.633 1383.86 628.665
dehydrogen ndria 42.1 OUSE G0000002 5556 3528 6291 4623 9336 0721 3719 3864 6768 1409 7065
ase E1 1748
component
subunit
beta,
mitochondr
ial
LDH Ldha ENZ muscle IPI003199 LDHA_M P06151 ENSMUS 16828 0.05555 0.60 9 2302.94 2115.54 1506.53 1938.87 1885.03 1520.05 454.021 1053.27 910.664 1899.43
muscle 94.6 OUSE G0000006 5556 3492 2896 4621 215 1178 9421 4532 3143 8943 0755
subunit 3229
Alpha-1- Serpina INH secreted IPI001239 A1AT4_ Q00897 ENSMUS 20703 0.05555 0.66 8 3612.41 5244.45 3176.25 3142.20 3380.39 1947.50 1209.70 3122.81 3418.34 2460.59
antitrypsin 1d 24.1 MOUSE G0000007 5556 1535 639 0677 155 9145 7827 4259 0979 369 3188
1-4 1177
Fibulin-5 Fbln5 CS secreted IPI003230 FBLN5_ Q9WVH9 ENSMUS 23876 0.05555 0.30 3 144.847 59.2279 149.891 74.4306 67.7430 20.3592 15.8326 86.9801 0 26.9239
35.3 MOUSE G0000002 5556 2061 2246 2434 0097 9972 4027 5371 8907 4126
1186
Annexin Anxa2 CS secreted IPI004682 ANXA2_ Q3UCD3 ENSMUS 12306 0.05555 0.60 7 824.134 659.071 729.303 504.226 1070.01 361.462 153.982 666.652 622.464 479.401
A2 03.3 MOUSE G0000003 5556 9001 8164 8648 3175 1176 2841 8219 2563 7489 3659
2231
Alpha-2- A2m INH secreted IPI006246 A2M_MO Q61838 ENSMUS 11287 0.05555 0.69 26 3437.89 2428.91 2124.92 2819.31 2201.57 1818.20 1291.81 2172.47 2254.34 1381.64
macroglobu 63.3 USE G0000003 5556 2031 8719 9299 6178 4795 386 4616 4392 1936 9886
lin 0359
Collagen Col6a3 CS secreted IPI008456 O88493_ O88493 0.05555 0.59 27 1804.68 1089.21 1566.23 1585.88 1830.86 493.120 417.546 1292.87 1177.48 1244.21
alpha 3 18.3 MOUSE 5556 2385 6422 4063 8446 3493 0199 4504 8326 7602 7417
chain type
VI
Calreticulin Calr CHA IPI001236 CALR_M Q3UWP8 ENSMUS 12317 0.05555 0.47 6 263.163 165.523 160.099 354.363 145.088 0 43.7167 126.358 121.384 224.201
39.1 OUSE G0000000 5556 8494 6366 597 5874 9954 8114 899 1707 6375
3814
Destrin Dstn CS IPI001279 DEST_M Q4FK36 ENSMUS 56431 0.05555 0.56 6 177.723 158.972 505.391 160.863 349.364 155.253 25.6753 135.645 334.978 101.321
42.4 OUSE G0000001 5556 9961 6131 388 9127 532 8691 9422 5563 9243 8618
5932
Serum Alb TP IPI001316 ALBU_M Q546G4 ENSMUS 11657 0.05555 0.55 36 36251.3 35447.0 24558.3 31967.6 79146.8 27427.5 11988.7 23538.2 25608.3 24569.7
albumin 95.3 OUSE G0000002 5556 14 184 3248 3782 4606 735 1801 3364 0461 5679
9368
Protein Pdia3 ENZ IPI002301 PDIA3_M P27773 ENSMUS 14827 0.05555 0.51 11 372.814 346.877 587.379 450.451 721.662 150.517 59.2638 356.883 261.870 429.226
disulfide- 08.6 OUSE G0000002 5556 3516 3561 1857 9633 0257 8448 8666 5217 9262 0961
isomerase 7248
A3
Vimentin Vim CS IPI009885 VIME_M Q3UD36 ENSMUS 22352 0.05555 0.60 32 7956.16 8799.64 12207.3 10451.3 9380.51 3605.86 2497.27 8645.25 8889.15 5412.30
39.1 OUSE G0000002 5556 9809 9882 0494 6571 5496 0906 2272 6528 6144 286
6728
Creatine Ckm ENZ muscle IPI001275 KCRM_ A2RTA0 ENSMUS 12715 0.05700 12.51 15 0 730.971 417.121 0 0 3861.60 1524.69 708.667 387.622 7878.92
kinase M- 96.1 MOUSE G0000003 7942 1843 721 4959 903 9105 6602 0896
type 0399
Myosin-7 Myh7 TP muscle IPI001306 MYH7_M B2RY26 ENSMUS 140781 0.05700 5.59 58 0 1011.79 4435.07 0 0 8004.21 4826.48 3206.80 362.851 14072.9
53.1 OUSE G0000005 7942 408 6863 7529 9209 2817 9378 5437

- 14 -
 3093
Isoform Myl1 TP muscle IPI003127 MYL1_M Q545T7 ENSMUS 17901 0.05700 8.26 10 0 1220.50 663.376 0 0 3835.14 2234.75 1103.39 502.792 7879.85
MLC1 of 00.4 OUSE G0000006 7942 1809 6421 8595 8933 9984 3711 4254
Myosin 1816
light chain
1/3, skeletal
muscle
isoform
hypothetica 993002 UK IPI002281 H3BL88_ Q5DTT0 ENSMUS 0.05700 7.46 4 0 0 82.4721 33.0273 0 52.2653 29.1177 243.618 142.990 393.124
l protein 1J03Rik 89.4 MOUSE G0000004 7942 4319 4956 7253 8384 4922 1124 7767
LOC24061 6138
3
Four and a Fhl1 DEV muscle IPI003099 FHL1_M P97447 ENSMUS 14199 0.05781 0.65 9 297.624 175.996 245.231 322.564 359.224 316.973 66.1164 168.664 124.896 239.905
half LIM 97.3/IPI00 OUSE G0000002 8306 5538 2974 2787 9842 938 0117 3862 133 9091 6605
domains 406672.3 3092
protein 1
Glutathione Gstm2 ENZ IPI006483 GSTM2_ D3YX76/ ENSMUS 14863 0.05792 0.69 14 758.535 709.423 1075.72 962.467 598.258 474.696 182.505 820.892 598.228 757.052
S- 36.1/IPI00 MOUSE P15626 G0000004 2533 6644 1181 6472 7651 2986 8707 7945 2518 4498 9734
transferase 228820.5 0562
Mu 2
NADH Ndufa2 ENZ mitocho IPI003153 NDUA2_ Q9CQ75 ENSMUS 17991 0.05932 0.34 3 188.651 173.236 144.766 129.667 42.3785 83.2352 70.3623 79.8241 0 0
dehydrogen ndria 02.5 MOUSE G0000001 7061 9383 863 0252 0678 6709 9936 4888 3125
ase 4294
[ubiquinone
] 1 alpha
subcomplex
subunit 2
Isoform 2 Sptan1 CS IPI007537 SPTA2_ Q58ES7 ENSMUS 0.05932 0.31 23 534.282 482.460 693.145 98.8616 512.165 0 0 305.074 245.201 159.199
of Spectrin 93.2 MOUSE G0000005 7061 1215 0282 198 2568 1656 2051 548 4781
alpha chain, 7738
brain
Disabled Dab1 SCA IPI009699 DAB1_M F2Z465 ENSMUS 13131 0.05932 0.51 1 328.947 420.198 464.731 370.588 415.405 0 0 351.891 395.683 266.656
homolog 1 83.1 OUSE G0000002 7061 8876 1838 2397 6391 7607 7047 8533 3517
8519
40S Rps14 RIB IPI003225 RS14_M O70569/D ENSMUS 20044 0.06080 0.17 5 128.730 89.3542 0 229.476 0 25.2947 0 0 0 0
ribosomal 62.5/IPI00 OUSE 3Z1P6 G0000006 2349 7987 3211 0645 3621
protein S14 112407.3 1848|ENS
MUSG00
00002460
8
Calponin-1 Cnn1 CS muscle IPI001166 CNN1_M Q08091 ENSMUS 12797 0.06330 0.52 9 759.573 689.894 1731.19 993.379 981.288 144.199 69.2646 1043.09 1095.22 334.042
45.1/IPI00 OUSE G0000000 8291 0701 1497 9302 8808 1322 4113 8582 06 019 0153
228258.1 1349
Caveolin-1 Cav1 SCA IPI008579 CAV1_M D3Z148/P ENSMUS 12389 0.06509 0.71 9 695.881 607.318 815.414 517.789 828.909 353.730 211.384 666.591 749.629 486.819
70.1/IPI00 OUSE 49817 G0000000 7117 3556 8985 918 9461 2384 2998 6875 8643 8766 3095
117829.1 7655
Cysteine Csrp2 DEV muscle IPI009885 CSRP2_ Q6QMT3 ENSMUS 13008 0.06695 0.34 4 273.323 288.443 224.327 235.384 0 0 0 210.635 132.156 0
and 82.1 MOUSE G0000002 5282 8153 6281 0508 3086 4534 2356
glycine-rich 0186
protein 2
Isoform 2 Mfge8 MOD secreted IPI003227 MFGM_ P21956 ENSMUS 17304 0.06695 0.04 10 241.329 225.272 958.708 0 223.542 0 0 0 35.3005 35.1567
of 12.2 MOUSE G0000003 5282 5794 0796 1648 2549 9273 5336
Lactadherin 0605
Glutathione Gstm7 ENZ IPI010161 GSTM7_ D3YVP6/ ENSMUS 68312 0.06753 1.57 8 1352.68 796.707 1563.26 448.900 366.639 0 0 1425.51 0 0
S- 84.1/IPI00 MOUSE D3YZ29 G0000000 7868 9903 15 5697 6784 2108 9323
transferase 648817.5 4035

- 15 -
Mu 7
Runt- Runx1 TF IPI002300 RUNX1_ Q03347 12394 0.06943 1000.00 3 0 0 0 0 0 210.331 116.962 0 0 460.850
related 39.2/IPI00 MOUSE 7899 692 7981 4665
transcriptio 876253.1
n factor 1
Keratin, Krt82 CS CONT IPI001172 KRT82_ Q99M74 ENSMUS 114566 0.07200 1000.00 1 0 0 0 0 0 404.065 198.340 0 0 467.454
type II AMINA 69.2 MOUSE G0000004 5658 1208 6337 1916
cuticular NT? 9548
Hb2
Creatine Ckmt2 ENZ mitocho IPI001200 KCRS_M Q6P8J7 ENSMUS 76722 0.07200 1000.00 5 0 0 0 0 0 322.138 146.575 0 0 824.305
kinase S- ndria 76.2 OUSE G0000002 5658 7015 2714 0564
type, 1622
mitochondr
ial
Voltage- Vdac3 CNL mitocho IPI001225 VDAC3_ Q3TX38 ENSMUS 22335 0.07200 1000.00 2 0 0 0 0 0 120.160 0 0 138.690 177.105
dependent ndria 48.4 MOUSE G0000000 5658 0964 6751 0068
anion- 8892
selective
channel
protein 3
Citrate Clybl ENZ mitocho IPI001539 CLYBL_ Q8R4N0 ENSMUS 69634 0.07200 0.00 5 226.588 182.633 324.150 0 0 0 0 0 0 0
lyase ndria 03.6 MOUSE G0000002 5658 1391 4685 0405
subunit 5545
beta-like
protein,
mitochondr
ial
Alcohol Adh1 ENZ mitocho IPI002214 ADH1_M Q3UKA4 ENSMUS 11522 0.07200 1000.00 3 0 0 0 0 0 14.1261 0 24.6091 0 129.038
dehydrogen ndria 00.5 OUSE G0000007 5658 2979 4745 9548
ase 1 4207
Arginase-2, Arg2 ENZ mitocho IPI001149 ARGI2_ Q8R1Q7 ENSMUS 11847 0.07200 1000.00 1 0 0 0 0 0 0 0 186.934 56.2222 198.545
mitochondr ndrial 74.1 MOUSE G0000002 5658 1671 7969 3098
ial 1125
NADH Ndufs4 ENZ mitocho IPI002290 NDUS4_ Q9CXZ1 17993 0.07200 0.00 3 79.5576 185.022 131.155 0 0 0 0 0 0 0
dehydrogen ndrial 08.2 MOUSE 5658 5977 6794 7446
ase
[ubiquinone
] iron-sulfur
protein 4,
mitochondr
ial
Enolase Eno2 ENZ muscle IPI001226 ENOG_M Q922A0 ENSMUS 13807 0.07200 1000.00 4 0 0 0 0 0 357.791 206.972 0 0 451.219
84.2 OUSE G0000000 5658 1593 9972 6897
4267
Alpha- Actn3 CS muscle IPI001367 ACTN3_ Q3UYE4 ENSMUS 11474 0.07200 1000.00 21 0 0 0 0 0 932.267 269.288 0 0 1548.80
actinin-3 01.1 MOUSE G0000000 5658 0608 3812 6553
6457
Myosin- Mybpc2 CS muscle IPI001699 MYPC2_ Q5XKE0 ENSMUS 233199 0.07200 1000.00 13 0 0 0 0 0 239.599 100.309 0 0 609.300
binding 94.4 MOUSE G0000003 5658 9719 2665 3649
protein C, 8670
fast-type
Troponin I, Tnni2 CS muscle IPI002231 TNNI2_M P13412 ENSMUS 21953 0.07200 1000.00 6 0 0 0 0 0 659.772 324.606 0 0 1115.20
fast skeletal 96.5 OUSE G0000003 5658 1714 2242 3753
muscle 1097
Parvalbumi Pvalb MOD muscle IPI002307 PRVA_M Q545M7 ENSMUS 19293 0.07200 1000.00 4 0 0 0 0 0 279.505 92.9202 0 0 484.504
n alpha 66.4 OUSE G0000000 5658 3728 7337 4477

- 16 -
 5716
Myosin-3 Myh3 TP muscle IPI003808 MYH3_M P13541 ENSMUS 17883 0.07200 1000.00 25 0 0 0 0 0 7583.51 3874.06 0 0 13800.1
95.7 OUSE G0000002 5658 5876 2276 3302
0908
Isoform Tnnt3 TP muscle IPI004657 TNNT3_ Q9QZ47 ENSMUS 21957 0.07200 1000.00 5 0 0 0 0 0 492.757 276.315 0 0 1101.85
B4e17 of 45.3 MOUSE G0000006 5658 1806 4579 7483
Troponin T, 1723
fast skeletal
muscle
Ryanodine Ryr3 CNL muscle IPI006066 RYR3_M A2AGL3 ENSMUS 0.07200 1000.00 3 0 0 0 0 0 305.764 342.008 338.544 0 0
receptor 3 38.6 OUSE G0000005 5658 8126 8375 5834
7378
striated Speg ENZ muscle IPI007623 SPEG_M Q62407 ENSMUS 11790 0.07200 1000.00 1 0 0 0 0 0 716.522 400.926 0 1193.55 0
muscle- 77.3 OUSE G0000002 5658 3743 3947 335
specific 6207
serine/threo
nine-
protein
kinase
isoform 2
Enamelin Enam CS secreted IPI001160 ENAM_ Q548P8 ENSMUS 13801 0.07200 1000.00 1 0 0 0 0 0 89.3756 55.2433 0 0 147.415
66.1 MOUSE G0000002 5658 746 4087 6432
9286
Collagen Col5a2 CS secreted IPI001211 CO5A2_ Q8BNA3 ENSMUS 12832 0.07200 0.00 9 297.566 160.570 219.184 0 0 0 0 0 0 0
alpha-2(V) 20.3 MOUSE G0000002 5658 3003 7787 6519
chain 6042
Isoform 1 Map6 CS IPI001158 MAP6_M Q7TSJ2 ENSMUS 17760 0.07200 0.00 3 59.8052 693.455 65.3076 0 0 0 0 0 0 0
of 33.2 OUSE G0000005 5658 9395 2735 4441
Microtubul 5407
e-
associated
protein 6
G-protein Gpr84 RCP IPI001181 GPR84_ Q8CIM5 ENSMUS 80910 0.07200 1000.00 1 0 0 0 0 0 47.1830 32.1709 0 111.111 0
coupled 69.2 MOUSE G0000006 5658 6314 0993 9266
receptor 84 3234
Isoform 2 Golga2 CS IPI001220 GOGA2_ Q921M4 ENSMUS 99412 0.07200 1000.00 1 0 0 0 0 0 141.242 133.240 0 0 541.188
of Golgin 12.8 MOUSE G0000000 5658 2841 3271 7065
subfamily 2546
A member
2
GTP- Rasl2-9 MOD IPI001261 RANT_M Q61820 ENSMUS 19428 0.07200 0.00 3 588.451 734.464 197.486 0 0 0 0 0 0 0
binding 33.1 OUSE G0000008 5658 3081 9474 2252
nuclear 3649
protein
Ran, testis-
specific
isoform
S-methyl- Mtap ENZ IPI001320 MTAP_M Q9CQ65 ENSMUS 66902 0.07200 1000.00 2 0 0 0 0 0 143.643 53.8398 0 0 513.128
5'- 96.3 OUSE G0000006 5658 0689 847 8075
thioadenosi 2937
ne
phosphoryl
ase
Vesicle- Vapb TP IPI001356 VAPB_M Q9QY76 0.07200 0.00 2 62.0776 143.238 63.9454 0 0 0 0 0 0 0
associated 55.3 OUSE 5658 2579 5955 876
membrane

- 17 -
protein-
associated
protein B
Photorecept Nr2e3 TF IPI001357 NR2E3_ Q543C7 ENSMUS 23958 0.07200 1000.00 2 0 0 0 0 0 170.718 32.7513 0 0 71.4912
or-specific 03.1 MOUSE G0000003 5658 8965 7663 2426
nuclear 2292
receptor
Ankyrin Ankrd5 UK IPI001372 ANR53_ Q3V0J4 ENSMUS 75305 0.07200 1000.00 2 0 0 0 0 0 0 4068.70 3767.26 5949.24 0
repeat 3 07.5 MOUSE G0000001 5658 5745 4781 4756
domain- 4747
containing
protein 53
Poly (ADP- Parp1 TF IPI001391 PARP1_ Q3TF18 0.07200 0.00 1 116.676 142.464 91.7364 0 0 0 0 0 0 0
ribose) 68.2 MOUSE 5658 1178 2794 3668
polymerase
family,
member 1
Isoform 1 Nf1 MOD IPI002233 NF1_MO B1AQE8 ENSMUS 18015 0.07200 0.00 2 0 97.7027 36.7343 36.8671 0 0 0 0 0 0
of 98.1 USE G0000002 5658 1072 2802 555
Neurofibro 0716
min
Dipeptidyl Dpp6 ENZ IPI002271 E9PWX1 Q8C8I1 ENSMUS 13483 0.07200 1000.00 1 0 0 0 0 0 132.453 65.5906 91.0833 0 0
aminopepti 14.1 _MOUSE G0000006 5658 8377 6544 2589
dase-like 1576
protein 6
Phosphogly Pgam2 ENZ IPI002307 PGAM2_ O70250 ENSMUS 56012 0.07200 1000.00 8 0 0 0 0 0 726.901 322.480 0 0 1219.06
cerate 06.5 MOUSE G0000002 5658 8151 1147 8309
mutase 2 0475
zinc finger Zfp438 TF IPI003127 Q8BFX2_ Q8BFX2 ENSMUS 240186 0.07200 1000.00 1 0 0 0 0 0 99.3326 89.3415 0 0 181.088
protein 438 56.2 MOUSE G0000005 5658 3233 7375 9885
0945
Actin- Actr8 TF IPI003212 ARP8_M Q8R2S9 ENSMUS 56249 0.07200 0.00 1 113.888 295.022 113.024 0 0 0 0 0 0 0
related 68.3 OUSE G0000001 5658 2657 4302 0305
protein 8 5971
Guanine Gnat1 MOD IPI003306 GNAT1_ P20612 ENSMUS 14685 0.07200 1000.00 2 0 0 0 0 0 235.404 127.749 0 0 280.530
nucleotide- 46.4 MOUSE G0000003 5658 0444 9892 1846
binding 4837
protein G(t)
subunit
alpha-1
Serine/thre Lats1 ENZ IPI004089 LATS1_ Q8BYR2 ENSMUS 16798 0.07200 1000.00 2 0 0 0 0 0 31.9500 248.723 0 0 74.9902
onine- 40.4 MOUSE G0000004 5658 4603 0672 4871
protein 0021
kinase
LATS1
DNA- Polr3b TF IPI004108 RPC2_M Q3TMK3 ENSMUS 70428 0.07200 0.00 2 81.0324 106.704 122.664 0 0 0 0 0 0 0
directed 71.1 OUSE G0000003 5658 1474 4047
RNA 4453
polymerase
III subunit
RPC2
Olfactory Olfr131 RCP IPI004110 Q7TQW8 Q8VER6 ENSMUS 258257 0.07200 1000.00 1 0 0 0 0 0 50.3392 39.7522 75.7791 0 0
receptor 3 38.1 _MOUSE G0000007 5658 3818 7021 471
1313 4946
Fam40a Fam40a UK IPI004157 Q8BUA9 Q8BUA9 0.07200 0.00 1 547.308 0 313.732 0 341.443 0 0 0 0 0
75.1 _MOUSE 5658 4058 5957 867

- 18 -
Elongation Eftud1 TF IPI004535 ETUD1_ Q8C0D5 ENSMUS 101592 0.07200 0.00 3 206.094 0 311.748 0 850.636 0 0 0 0 0
factor Tu 32.2 MOUSE G0000003 5658 6179 09 8072
GTP- 8563
binding
domain-
containing
protein 1
activating Ascc3 TF IPI005536 ASCC3_ E9PZJ8 ENSMUS 77987 0.07200 1000.00 2 0 0 0 0 0 105.232 31.1090 0 0 255.747
signal 87.6 MOUSE G0000003 5658 9095 6567 5259
cointegrator 8774
1 complex
subunit 3
isoform 2
Isoform 3 Akap9 SCA IPI006237 AKAP9_ Q8BV41 ENSMUS 100986 0.07200 0.00 3 234.140 254.291 0 355.785 0 0 0 0 0 0
of A-kinase 49.2 MOUSE G0000004 5658 9045 5052 7434
anchor 0407
protein 9
SH3- Sgip1 SCA IPI006533 SGIP1_M E9PVY1 ENSMUS 73094 0.07200 1000.00 1 0 0 0 0 0 258.056 158.861 0 0 463.824
containing 74.1 OUSE G0000002 5658 6956 5152 7273
GRB2-like 8524
protein 3-
interacting
protein 1
Isoform 5 Lpp CS IPI006563 LPP_MO Q8BFW7 ENSMUS 210126 0.07200 0.00 5 234.215 96.0167 299.379 0 0 0 0 0 0 0
of Lipoma- 13.1 USE G0000003 5658 3401 9047 0633
preferred 3306
partner
homolog
Ral Ralgapb MOD IPI006638 RLGPB_ A2ACC6 ENSMUS 228850 0.07200 1000.00 2 0 0 0 0 0 70.3074 0 39.8104 90.6431 0
GTPase- 02.1 MOUSE G0000002 5658 8102 3722 5407
activating 7652
protein
subunit
beta
Protein Sec24b TP IPI007537 Q3UDH4 Q3U882 ENSMUS 0.07200 1000.00 1 0 0 0 0 0 80.9044 0 0 126.038 92.8210
transport 94.1 _MOUSE G0000000 5658 8698 4677 7204
protein 1052
Sec24B
fer-1-like Fer1l4 TM IPI007579 FR1L4_M Q9D2X7 ENSMUS 74562 0.07200 1000.00 1 0 0 0 0 0 90.7584 71.4806 0 155.963 0
protein 4 63.7 OUSE G0000001 5658 3586 7008 188
3338
Isoform 1 Rbm33 TF IPI007598 RBM33_ Q9CXK9 ENSMUS 381626 0.07200 0.00 1 0 455.306 278.101 374.405 0 0 0 0 0 0
of RNA- 58.2 MOUSE G0000004 5658 9679 6835 6131
binding 8271
protein 33
Isoform 2 Pawr TF IPI008169 PAWR_M Q3UWE8 ENSMUS 114774 0.07200 1000.00 1 0 0 0 0 0 144.250 107.957 0 259.197 0
of PRKC 41.1 OUSE G0000003 5658 5985 6093 1783
apoptosis 5873
WT1
regulator
protein
Tensin-like Tenc1 ENZ IPI008169 TENC1_ Q8CGB6 ENSMUS 209039 0.07200 1000.00 2 0 0 0 0 0 266.198 214.335 0 0 783.023
C1 domain- 69.1 MOUSE G0000003 5658 3544 2847 3674
containing 7003
phosphatas
e
Ethylmalon Echdc1 ENZ IPI008289 ECHD1_ Q9D9V3 ENSMUS 52665 0.07200 0.00 3 160.962 179.350 0 0 53.7279 0 0 0 0 0

- 19 -
yl-CoA 65.1 MOUSE G0000001 5658 2215 2914 3569
decarboxyl 9883
ase
Protein Prrc2c UK IPI008315 PRC2C_ Q3TLH4 0.07200 0.00 5 1032.49 1292.62 1397.30 0 0 0 0 0 0 0
PRRC2C 15.3 MOUSE 5658 5638 99 0558
Transcripti Sox6 TF IPI008497 SOX6_M Q8BSS6 ENSMUS 20679 0.07200 1000.00 2 0 0 0 0 0 148.094 0 64.8345 0 267.172
on factor 89.1 OUSE G0000005 5658 3379 5829 3118
SOX-6 1910
Protein Vmn2r6 RCP IPI008572 E9Q1T0_ E9Q1T0 ENSMUS 620672 0.07200 1000.00 1 0 0 0 0 0 216.654 124.596 0 486.751 0
Vmn2r67 7 40.1 MOUSE G0000009 5658 2114 0397 1314
1901
60S Rpl13 RIB IPI008901 RL13_M E9PZ94 ENSMUS 270106 0.07200 0.00 3 0 92.3639 118.317 201.953 0 0 0 0 0 0
ribosomal 96.2 OUSE G0000005 5658 9664 5365 9927
protein L13 9776|ENS
MUSG00
00000074
0
Dedicator Dock2 MOD IPI008950 DOCK2_ D6RGU3 ENSMUS 94176 0.07200 1000.00 1 0 0 0 0 0 650.473 354.537 0 0 1073.19
of 46.1 MOUSE G0000002 5658 0951 924 655
cytokinesis 0143
protein 2
Protein Ahnak2 DEV IPI009183 F7CVJ5_ F7CVJ5 ENSMUS 0.07200 0.00 4 104.165 0 230.978 0 309.467 0 0 0 0 0
AHNAK2 05.1 MOUSE G0000007 5658 8235 2149 6538
(Neuroblast 2812
differentiati
on-
associated
protein
AHNAK2)
Condensin Ncapg CC IPI009748 Q9JK28_ Q9JK28 0.07200 1000.00 2 0 0 0 0 0 0 92.7652 652.320 692.469 0
complex 76.1 MOUSE 5658 3673 5077 9308
subunit 3
Programme Pdcd7 TF IPI009874 PDCD7_ E9Q211 ENSMUS 0.07200 1000.00 2 0 0 0 0 0 103.803 38.1670 45.2185 0 0
d cell death 06.1 MOUSE G0000004 5658 0365 1676 284
protein 7 1837
Microtubul Mast4 ENZ IPI009903 MAST4_ E9PWX8 ENSMUS 328329 0.07200 1000.00 3 0 0 0 0 0 362.652 0 0 62.3869 43.3384
e- 07.1 MOUSE G0000003 5658 0653 542 7422
associated 4751
serine/threo
nine-
protein
kinase 4
Interferon- Irgc ENZ IPI010085 IIGP5_M E9PZL6 ENSMUS 0.07200 0.00 1 124.198 75.2222 36.7599 0 0 0 0 0 0 0
inducible 11.1 OUSE G0000006 5658 2853 0487 4519
GTPase 5 2028
C2 domain- C2cd3 DEV IPI010085 C2CD3_ E9Q931 ENSMUS 277939 0.07200 1000.00 2 0 0 0 0 0 67.9820 17.0216 0 0 31.1384
containing 72.1 MOUSE G0000004 5658 334 3704 2866
protein 3 7248
Receptor- Ptprv ENZ IPI010232 PTPRV_ F6X1Y6 ENSMUS 0.07200 1000.00 2 0 0 0 0 0 36.9939 39.9477 0 0 321.136
type 93.1 MOUSE G0000006 5658 3765 7831 1509
tyrosine- 6885
protein
phosphatas
eV
Novel Gm127 UK IPI010267 A2BH64_ G3UZE4 ENSMUS 10004386 0.07200 1000.00 1 0 0 0 0 0 237.007 116.871 0 158.796 0
protein 76 87.1 MOUSE G0000007 8 5658 5043 3561 3035

- 20 -
similar to 8752
androgen
binding
protein
alpha
(Abpa)
Protein Fam92b UK IPI010268 FA92B_ G3UYC8 ENSMUS 0.07200 0.00 1 0 264.212 312.730 0 372.624 0 0 0 0 0
FAM92B 39.1 MOUSE G0000004 5658 2017 313 9121
2269
H-2 class I H2-D1 MHC IPI010268 HA11_M P01899 ENSMUS 14964 0.07200 0.00 1 53.5228 51.4355 0 0 42.7390 0 0 0 0 0
histocompa 78.1 OUSE G0000007 5658 418 9796 2154
tibility 3411
antigen, D-
B alpha
chain
Cytochrom Cyc1 TP mitocho IPI008457 CY1_MO Q9D0M3 ENSMUS 66445 0.07463 7.51 8 0 0 0 277.395 0 554.090 178.442 415.120 935.530 0
e c1, heme ndria 72.1 USE G0000002 9183 0688 0609 443 7525 0581
protein, 2551
mitochondr
ial
Myosin Mylpf TP muscle IPI002245 MLRS_M P97457 ENSMUS 17907 0.07463 17.21 8 0 468.664 0 0 0 2665.71 1277.78 325.605 0 3797.43
regulatory 49.3 OUSE G0000003 9183 8509 9273 1226 9378 0626
light chain 0672
2, skeletal
muscle
isoform
Protein 493053 UK IPI001375 Q9D500_ Q9D500 ENSMUS 0.07463 9.35 1 0 0 138.665 0 0 353.522 227.269 127.020 0 588.794
4930533L0 3L02Ri 61.1 MOUSE G0000005 9183 5098 3241 292 855 8866
2Rik k 1614
Leucine- Lrrk2 ENZ IPI002275 LRRK2_ Q5S006 ENSMUS 66725 0.07463 17.87 5 0 116.849 0 0 0 730.081 265.531 87.0421 0 1005.04
rich repeat 65.3 MOUSE G0000003 9183 8625 8591 0692 2655 4392
serine/threo 6273
nine-
protein
kinase 2
Protein Ptar1 ENZ IPI003570 E9QAB6_ E9QAB6 ENSMUS 72351 0.07463 4.08 1 87.1486 0 0 0 0 87.9584 50.5588 118.421 98.8177 0
prenyltransf 56.5 MOUSE G0000007 9183 8084 5239 5972 1707 8499
erase alpha 4925
subunit
repeat-
containing
protein 1
Transcripti Vgll4 TF IPI008566 VGLL4_ D3YZY3 ENSMUS 232334 0.07463 5.58 3 0 0 0 0 518.330 588.490 436.191 790.687 1079.09 0
on cofactor 59.1 MOUSE G0000003 9183 9675 7723 7456 2794 1525
vestigial- 0315
like protein
4
Collagen Col6a2 CS secreted IPI007528 CO6A2_ D3Z7D5/ ENSMUS 12834 0.07574 0.69 20 812.034 844.806 1265.26 454.191 807.929 422.258 294.641 808.620 757.722 609.721
alpha-2(VI) 25.2/IPI00 MOUSE Q02788 G0000002 2242 9621 7784 0443 1464 9252 5418 0484 3172 4487 2604
chain 621027.2 0241
60S Rpl10a RIB IPI008499 RL10A_ Q5XJF6/P ENSMUS 0.08074 0.74 5 83.5150 78.6460 0 0 79.1623 0 0 0 59.5966 0
ribosomal 27.1/IPI00 MOUSE 53026 G0000003 1962 8141 9129 5774 1754
protein 127085.6 7805
L10a
Membrane Aoc3 ENZ IPI006499 AOC3_M A2A4I8/O ENSMUS 11754 0.08082 0.83 9 430.768 522.180 371.390 133.967 562.318 176.137 0 257.764 574.131 0
primary 20.1/IPI00 OUSE 70423 G0000001 805 1392 4871 4377 2835 3973 3419 5816 4199
amine 118173.1 9326

- 21 -
oxidase
Pyruvate Pkm2 ENZ muscle IPI008458 KPYM_M P52480 ENSMUS 18746 0.08395 0.66 23 2650.64 2613.88 1963.85 1990.22 4193.84 3428.41 771.671 1350.86 1550.84 1739.72
kinase 40.1/IPI00 OUSE G0000003 8537 6935 7203 8885 4371 2395 0746 0783 2247 8114 0891
isozymes 407130.4 2294
M1/M2
Proteoglyca Prg4 CS IPI009698 PRG4_M E0CZ58/E ENSMUS 96875 0.08408 3.78 11 0 0 163.546 0 0 1023.26 189.535 0 0 643.070
n4 92.1/IPI00 OUSE 9QLV4/Q G0000000 6405 3111 1134 7797 3901
876340.2/ 9JM99 6014
IPI006523
94.2
Tropomyos Tpm2 CS muscle IPI001233 TPM2_M Q9D1R6/ ENSMUS 22004 0.08543 1.89 35 1793.75 1553.87 2878.62 2135.13 1059.93 4020.34 2591.89 3022.70 1104.28 7069.79
in beta 19.1/IPI00 OUSE P58774 G0000002 1309 042 8617 5525 1866 0175 3193 7511 1222 7833 676
chain 874728.1 8464
Inositol Ppip5k1 ENZ IPI002226 VIP1_MO A2ARP0/ ENSMUS 327655 0.08641 0.00 2 57.4969 61.9656 0 0 229.623 0 0 0 0 0
hexakispho 62.4/IPI00 USE F6Q5C6 G0000003 5266 2238 148 8844
sphate and 918367.1 3526
diphosphoi
nositol-
pentakispho
sphate
kinase 1
Caldesmon Cald1 CS muscle IPI003113 E9QA15_ E9QA15 ENSMUS 0.09068 0.33 18 668.109 430.694 1163.48 0 414.661 193.672 0 363.798 327.193 0
44.4 MOUSE G0000002 8366 6422 6645 0427 0859 4227 6917 0456
9761
Monoglyce Mgll ENZ IPI006528 MGLL_M Q3UFN1 ENSMUS 23945 0.09068 0.30 4 139.899 85.4986 79.7337 0 103.596 35.2522 0 24.6098 63.2518 0
ride lipase 48.1 OUSE G0000003 8366 9989 5762 0901 7699 3481 7913 1394
3174
Synaptotag Sytl2 TP IPI004688 SYTL2_ Q99N50 ENSMUS 83671 0.09118 1000.00 2 0 0 0 0 0 89.0327 0 114.958 0 0
min-like 87.3/IPI00 MOUSE G0000003 7001 1851 3555
protein 2 944088.1 0616
Transgelin- Tagln2 DEV muscle IPI001257 TAGL2_ Q9WVA4 ENSMUS 21346 0.09523 0.57 8 960.824 863.187 1587.36 1436.05 1261.39 565.380 198.216 1073.58 1030.53 620.915
2 78.4 MOUSE G0000002 8095 6169 6009 9433 0617 811 2647 0613 2641 6779 7383
6547
Prolargin Prelp CS secreted IPI001222 PRELP_ Q9JK53 ENSMUS 116847 0.09523 0.59 9 706.934 429.257 811.846 550.898 348.454 294.440 117.997 518.799 504.913 234.462
93.3 MOUSE G0000004 8095 903 6244 9591 9786 5359 7369 4965 9687 8712 3539
1577
Alpha-1- Serpina INH secreted IPI001239 A1AT3_ Q00896 ENSMUS 20702 0.09523 0.71 9 4144.28 5180.86 3357.20 3238.39 4077.11 2148.78 1340.86 3096.81 4069.08 3499.21
antitrypsin 1c 20.2 MOUSE G0000007 8095 6563 7076 7238 0547 7522 2905 2541 2095 747 5645
1-3 9015
Transthyret Ttr TP secreted IPI001275 TTHY_M P07309 ENSMUS 22139 0.09523 0.52 5 1191.46 1142.61 523.253 427.331 947.000 423.238 334.394 568.135 461.116 429.162
in 60.1 OUSE G0000006 8095 7007 1491 7114 9311 4731 0256 6664 4364 5891 9147
1808
Serine Serpina INH secreted IPI001318 SPA3K_ P07759 ENSMUS 20714 0.09523 0.65 7 1541.23 1627.04 975.749 1062.21 1952.68 1042.78 433.408 769.469 1585.00 791.245
protease 3k 30.1 MOUSE G0000005 8095 7957 1444 4108 9064 043 9515 4519 3324 5723 6558
inhibitor 8207
A3K
Collagen Col6a1 CS secreted IPI003398 CO6A1_ Q04857 ENSMUS 12833 0.09523 0.54 12 1015.76 780.159 1318.58 479.562 1198.31 359.634 218.045 886.775 566.683 567.207
alpha-1(VI) 85.2 MOUSE G0000000 8095 2349 5334 3008 1735 4277 8341 5649 2974 729 9406
chain 1119
Polymerase Ptrf TF IPI001176 PTRF_M O54724 ENSMUS 19285 0.09523 0.63 10 927.367 732.592 1110.10 735.329 945.202 497.765 235.047 762.097 863.453 433.458
I and 89.1 OUSE G0000000 8095 3122 0667 7709 3006 109 446 3172 37 4771 1712
transcript 4044
release
factor
Endoplasmi Hsp90b CHA IPI001295 ENPL_M P08113 ENSMUS 22027 0.09523 0.44 13 493.825 325.395 524.886 1122.75 929.690 138.484 73.5061 306.178 344.683 635.995
n 1 26.1 OUSE G0000002 8095 8706 1763 4898 34 821 0858 9705 3404 3108 218

- 22 -
 0048
Superoxide Sod1 ENZ IPI001305 SODC_M P08228 ENSMUS 20655 0.09523 0.72 6 1317.28 1025.53 1354.24 1286.49 862.187 438.173 558.213 1021.53 1155.17 1011.97
dismutase 89.8 OUSE G0000002 8095 5767 2531 1118 6051 268 933 2526 0235 4963 4179
[Cu-Zn] 2982
60S Rpl8 RIB IPI001377 RL8_MO Q3UJS0 ENSMUS 26961 0.09523 0.40 3 49.5656 63.7805 32.7532 224.949 36.9597 32.2799 10.3876 27.9341 24.2485 69.6199
ribosomal 87.3 USE G0000000 8095 0672 6741 082 5926 4541 642 8162 9423 4242 3133
protein L8 3970
Carbonic Ca3 ENZ IPI002218 CAH3_M P16015 ENSMUS 12350 0.09523 0.75 12 5203.89 4661.84 4112.73 4120.92 4423.87 3168.77 1108.51 4076.73 4906.49 3609.02
anhydrase 3 90.6 OUSE G0000002 8095 2965 6256 1184 0383 3049 9603 3772 2492 492 4934
7559
Carbonic Ca1 ENZ IPI002303 CAH1_M P13634 12346 0.09523 2.36 7 585.024 195.940 193.950 0 68.1250 246.594 915.968 571.898 496.969 232.797
anhydrase 1 20.6 OUSE 8095 0798 2992 9814 0173 6737 6395 4796 7562 6296
Vacuolar Vps4a TP IPI003121 VPS4A_ Q8VEJ9 ENSMUS 116733 0.09523 0.54 1 1733.13 1562.89 1019.74 1425.37 436.251 395.306 578.119 840.845 964.376 565.496
protein 72.5 MOUSE G0000003 8095 4694 4145 8644 1376 1428 0003 2409 348 4059 0078
sorting- 1913
associated
protein 4A
Annexin Anxa5 INH IPI003173 ANXA5_ P48036 ENSMUS 11747 0.09523 0.69 6 546.783 732.319 717.413 663.462 850.640 324.050 208.660 587.985 616.370 690.591
A5 09.5 MOUSE G0000002 8095 1057 5194 34 6539 5588 5465 4014 2679 3975 2217
7712
78 kDa Hspa5 MOD IPI003199 GRP78_ Q3TUS2 ENSMUS 14828 0.09523 0.56 11 656.755 666.461 719.617 1792.94 618.527 379.590 180.825 487.590 592.756 866.178
glucose- 92.1 MOUSE G0000002 8095 7229 0987 4705 527 74 3916 8343 9576 4166 1778
regulated 6864
protein
Vinculin Vcl CS IPI004052 VINC_M Q64727 ENSMUS 22330 0.09523 0.51 36 1549.32 1285.79 2515.29 1496.83 1492.53 555.735 448.304 1613.80 1103.18 517.785
27.3 OUSE G0000002 8095 9738 1961 787 5187 1443 4336 073 6787 9008 436
1823
Nuclear Nup85 TP IPI004615 NUP85_ Q8R480 ENSMUS 445007 0.09523 0.53 1 377.303 735.552 575.075 720.014 266.308 221.624 181.996 478.140 525.017 0
pore 32.4 MOUSE G0000002 8095 7208 5509 1135 7818 3034 8108 8451 3097 8954
complex 0739
protein
Nup85
Elongation Eef2 TF IPI004660 EF2_MO P58252 ENSMUS 13629 0.09523 0.37 17 507.626 441.095 486.147 2329.35 576.502 396.770 0 294.083 247.137 686.523
factor 2 69.3 USE G0000003 8095 2746 6957 5022 0187 7132 527 4561 5937 2667
4994
Heat shock Hsp90a CHA IPI005549 HS90B_ P11499 ENSMUS 15516 0.09523 0.74 16 1383.10 1144.42 1366.10 926.453 1463.76 912.699 537.631 1028.15 1041.74 1144.67
protein b1 29.3 MOUSE G0000002 8095 1867 8844 3316 2767 1942 323 5015 843 133 0273
HSP 90- 3944
beta
Peptidyl- Ppia CHA IPI005549 PPIA_MO P17742 ENSMUS 268373 0.09523 0.66 3 516.250 608.363 454.370 501.581 876.172 423.133 158.804 494.244 327.524 559.421
prolyl cis- 89.3 USE G0000006 8095 9586 5215 2398 2941 9975 0111 9024 7412 0718 5557
trans 2933|ENS
isomerase MUSG00
A 00007186
6
Phosphogly Pgk1 ENZ IPI005550 PGK1_M P09411 ENSMUS 18655 0.09523 0.68 9 1222.12 1137.92 1180.22 1177.37 662.796 803.499 390.764 750.211 877.336 810.715
cerate 69.3 OUSE G0000006 8095 1769 2472 9759 0924 3629 3799 7181 2626 4284 3368
kinase 1 2070
NADH- Cyb5r3 ENZ IPI007599 NB5R3_ Q9DCN2 ENSMUS 109754 0.09523 0.48 4 221.472 121.523 227.215 118.480 258.950 52.7955 26.8724 89.2376 137.938 149.861
cytochrome 04.1 MOUSE G0000001 8095 9576 4939 1269 9119 1121 9996 3736 2268 5908 1273
b5 8042
reductase 3
Probable Ttll1 ENZ IPI008579 TTLL1_ Q8BJG7 ENSMUS 319953 0.09523 1.41 1 202.076 270.164 225.523 259.847 0 325.876 115.418 273.156 311.480 326.815
tubulin 46.3 MOUSE G0000002 8095 6029 2854 2485 0947 8293 2578 1201 0715 4779
polyglutam 2442
ylase

- 23 -
TTLL1
Adiponecti Adipoq SIG secreted IPI009859 ADIPO_ E9PWU4/ ENSMUS 11450 0.09804 0.48 3 119.348 101.650 133.052 0 0 0 32.3359 0 80.2749 0
n 88.1/IPI00 MOUSE Q60994 G0000002 6953 3183 5481 9776 4816 1192
311383.1 2878
Oxidation Oxr1 MOD IPI009870 OXR1_M F8WGG8/ ENSMUS 170719 0.10091 2.24 6 95.1802 59.9225 286.280 0 0 145.252 158.856 389.451 0 625.722
resistance 57.2/IPI00 OUSE Q4KMM3 G0000002 5114 9189 9291 9779 8462 4375 688 2669
protein 1 957111.1/ 2307
IPI009569
19.1
Ig gamma- Igh-3 IGG secreted IPI008306 IGG2B_ P01867/Q 0.10191 0.10 6 0 244.294 0 0 179.752 0 0 0 0 22.2078
2B chain C 19.2/IPI00 MOUSE 8R3H6 6569 4557 1933 3155
region 153758.1
Terminal Zcchc6 ENZ IPI004613 TUT7_M Q8CD38/ ENSMUS 214290 0.10211 3.19 6 50.6366 25.6589 0 0 0 172.739 0 0 38.1334 154.419
uridylyltran 11.1/IPI00 OUSE E9PUA2 G0000003 4816 3473 247 6576 8726 705
sferase 7 621663.4 5248
Branched- Bcat2 ENZ mitocho IPI008863 BCAT2_ D3Z7C8/ ENSMUS 12036 0.10543 1.08 6 96.2698 0 170.908 177.203 0 103.222 79.3180 162.275 177.035 275.918
chain- ndria 99.1/IPI00 MOUSE O88374 G0000003 4394 6066 8168 4127 4136 9203 6596 1872 2083
amino-acid 886333.1 0826
aminotransf
erase,
mitochondr
ial
Myosin Myl12a TP IPI001090 Q6ZWQ9 Q922W7/ ENSMUS 67268 0.10926 0.38 5 569.841 532.702 0 0 626.259 235.498 185.650 0 0 242.058
regulatory 44.8/IPI00 _MOUSE D3YV37 G0000002 1133 6075 6162 6616 6486 7885 3446
light chain 956948.1 4048
RLC-A
Spectrin Sptbn1 CS IPI008313 SPTB2_M P70435/Q ENSMUS 20742 0.10936 0.43 59 1517.41 2529.79 3082.45 0 3778.34 1530.26 330.914 2105.97 1349.56 522.069
beta chain, 69.1/IPI00 OUSE 62261 G0000002 3782 148 839 0678 578 2654 787 4432 5523 7218
brain 1 319830.7/ 0315
IPI001218
92.9
Basement Hspg2 CS secreted IPI009749 PGBM_M E9QL02/ ENSMUS 15530 0.10988 0.73 39 490.743 422.576 713.078 311.816 1082.58 150.860 0 507.345 355.471 746.970
membrane- 97.1/IPI00 OUSE Q2XQV0 G0000002 2807 8302 3394 9252 7202 6814 2087 8706 2136 4748
specific 515360.8 8763
heparan
sulfate
proteoglyca
n core
protein
Myosin Mylk ENZ muscle IPI001254 MYLK_ Q6PDN3 ENSMUS 0.11200 0.45 15 308.642 153.634 420.051 0 0 0 0 152.631 110.366 0
light chain 93.5/IPI00 MOUSE G0000002 3628 3968 1302 9039 7352 6798
kinase, 467582.3 2836
smooth
muscle
Glutathione Gstm1 ENZ IPI006491 GSTM1_ A2AE89/ ENSMUS 14862 0.11276 0.77 21 1546.49 1227.13 1901.84 1764.46 1302.63 899.070 425.505 1752.78 1400.30 1461.06
S- 35.3/IPI00 MOUSE P10649 G0000005 1197 8784 3902 2394 6893 1417 3586 4317 1574 2169 2365
transferase 230212.5 8135
Mu 1
60S Rpl18 RIB IPI010267 RL18_M G3UYV6/ ENSMUS 19899 0.11294 0.62 9 151.230 99.9744 267.554 288.422 0 80.6504 0 101.621 0 195.379
ribosomal 49.1/IPI01 OUSE G3UZK4/ G0000005 0129 1705 2756 9653 8226 9261 776 9746
protein L18 027195.1/ Q58EW0 9070
IPI005551
13.2
Klotho Kl ENZ secreted IPI006531 KLOT_M O35082 ENSMUS 16591 0.11318 0.00 2 0 0 721.378 1057.86 5274.15 0 0 0 0 0
62.3/IPI00 OUSE G0000005 1453 9332 9079 1206
124625.3 8488

- 24 -
14-3-3 Ywhaq SCA IPI006562 1433T_M P68254 ENSMUS 22630 0.11364 0.82 17 1800.29 1922.37 2108.73 1120.52 1075.57 584.969 0 974.750 1929.00 1751.43
protein 69.1/IPI00 OUSE G0000007 7628 9866 3414 8139 2152 7361 8534 3776 9261 6318
theta 989726.1 6432
Peroxiredo Prdx1 ENZ IPI006481 PRDX1_ B1AXW5 ENSMUS 18477 0.11454 0.45 14 1239.87 953.083 1021.87 1035.64 4409.20 726.487 287.823 958.605 863.976 1033.86
xin-1 05.1/IPI00 MOUSE /P35700 G0000002 7398 7183 5655 123 3016 7623 2773 7836 2054 2771 5774
121788.1 8691
S- Amd1 ENZ IPI001311 DCAM1_ P31154 ENSMUS 11702 0.11607 0.65 1 779.951 852.411 1044.96 1053.09 0 0 444.358 752.704 724.770 505.332
adenosylme 87.1 MOUSE G0000006 3943 5964 4763 1082 2664 7431 1815 9634 3037
thionine 0096|ENS
decarboxyl MUSG00
ase 00007523
proenzyme 2
1
60S Rpl7 RIB IPI003112 RL7_MO Q5M9N8 ENSMUS 19989 0.11607 0.22 5 45.0639 42.2356 50.9237 274.961 0 14.0948 10.8985 37.9015 0 28.9079
ribosomal 36.1 USE G0000004 3943 9011 1249 4534 4265 3487 7825 0103 2703
protein L7 3716
Heat shock Hsp90a CHA IPI003308 HS90A_ P07901 ENSMUS 15519 0.11607 0.47 11 647.130 385.827 458.138 0 656.632 187.512 0 255.610 233.907 327.454
protein a1 04.4 MOUSE G0000002 3943 3001 3792 4916 5676 2173 3336 3592 7114
HSP 90- 1270
alpha
Acyl-CoA- Dbi TP IPI008316 ACBP_M D3Z563 ENSMUS 13167 0.11607 0.27 4 708.524 561.788 454.849 0 603.363 180.642 36.9976 66.9043 355.227 0
binding 93.1 OUSE G0000002 3943 4931 0805 8467 4637 8683 1314 2823 9555
protein 6385
Dihydropyr Dpysl3 CS IPI008814 DPYL3_ Q3TT92 ENSMUS 22240 0.11607 0.45 8 188.319 205.951 373.949 0 564.399 88.9323 0 144.739 182.262 185.225
imidinase- 85.1 MOUSE G0000002 3943 7095 0853 1334 3458 9537 9168 8027 0013
related 4501
protein 3
Eukaryotic Eif4a2 TF IPI008579 IF4A2_M D6RJ60/Q ENSMUS 13682 0.11698 0.73 6 259.440 125.591 0 0 82.1619 0 0 0 113.532 0
initiation 90.1/IPI00 OUSE 8BTU6 G0000002 3883 8312 4189 1279 1846
factor 4A-II 857127.1 2884
Phospholipi Gpx4 ENZ mitocho IPI004632 GPX41_ Q8K4U7/ ENSMUS 625249 0.11698 0.26 3 81.6278 66.3962 0 0 0 19.0114 0 0 0 0
d ndria 20.2/IPI00 MOUSE O70325 G0000007 5632 7488 3535 3914
hydroperox 989123.1 5706
ide
glutathione
peroxidase,
mitochondr
ial
Non- Scp2 TP mitocho IPI006484 NLTP_M P32020 ENSMUS 20280 0.11710 0.55 5 191.114 164.855 141.609 0 0 59.4496 0 0 122.919 0
specific ndria 76.1/IPI00 OUSE G0000002 9215 6335 7499 7387 603 3476
lipid- 134131.2 8603
transfer
protein
GTP:AMP Ak3 ENZ mitocho IPI002217 KAD3_M Q9WTP7 ENSMUS 56248 0.11879 3.50 5 0 192.799 0 0 0 132.018 70.6662 221.662 250.287 0
phosphotra ndria 69.5 OUSE G0000002 7498 7515 4384 0788 2841 2468
nsferase, 4782
mitochondr
ial
Putative D73000 UK IPI006530 Q3UP29_ Q3UP29 0.11879 8.95 2 0 141.318 0 0 0 322.601 105.041 127.694 0 709.935
uncharacter 5E14Ri 00.1 MOUSE 7498 5325 1394 8166 9323 9127
ized protein k
D730005E1
4Rik
Chaperone Adck3 CHA mitocho IPI001225 ADCK3_ Q60936 ENSMUS 67426 0.11938 2.45 8 111.309 45.7817 166.005 192.629 0 317.778 68.7440 601.879 277.220 0
activity of ndria 54.3/IPI00 MOUSE G0000002 7073 0513 7616 6198 7369 2459 1946 4438 3335
bc1 816885.1 6489

- 25 -
complex-
like,
mitochondr
ial
Methylcrot Mccc1 ENZ mitocho IPI006525 MCCA_ Q3TVD9/ ENSMUS 72039 0.12013 0.46 19 452.514 456.459 535.389 547.754 0 161.649 30.7834 305.679 521.909 129.153
onoyl-CoA ndria 21.1/IPI00 MOUSE D6RI29/Q G0000002 3879 3999 3123 8562 3693 7346 6418 9814 0489 416
carboxylase 881206.1/ 99MR8 7709
subunit IPI003208
alpha, 50.3
mitochondr
ial
NFX1-type Znfx1 TF IPI006752 ZNFX1_ A2A5R4/ ENSMUS 98999 0.12214 1.12 4 0 66.2637 113.195 99.3903 0 89.0157 30.8321 129.102 206.962 66.3123
zinc finger- 95.2/IPI00 MOUSE A2A5R5 G0000003 2219 2369 9931 3435 9567 6084 6219 0179 0983
containing 222329.12 9501
protein 1
Mitochondr Immt TM mitocho IPI009856 IMMT_M Q2YDW0 ENSMUS 76614 0.12317 0.74 39 1321.30 1070.66 1209.54 1097.76 339.842 716.813 422.763 815.169 1096.10 692.992
ial inner ndria 26.2/IPI00 OUSE /Q8CAQ8 G0000005 816 3172 4408 7634 8602 3377 7197 8168 9761 5509 1088
membrane 381412.1 2337
protein
Mitofilin
Voltage- Vdac1 CNL mitocho IPI008570 VDAC1_ F2Z471/Q ENSMUS 22333 0.12526 1.56 9 262.627 384.949 362.237 145.496 392.024 542.715 219.587 419.621 298.202 926.939
dependent ndria 67.1/IPI00 MOUSE 60932 G0000002 7707 8243 9489 4673 1231 0839 8311 6113 296 6633 9499
anion- 230540.1 0402
selective
channel
protein 1
Prelamin- Lmna CS IPI004003 LMNA_ P48678 ENSMUS 16905 0.12666 0.77 30 2036.25 2022.13 2288.45 2048.98 906.729 1143.84 775.768 1840.11 2173.27 1208.76
A/C 00.1/IPI00 MOUSE G0000002 5167 561 3655 9863 5271 229 9699 0704 9469 5871 4185
620256.3 8063
40S Rps2 RIB IPI006051 RS2_MO D3YWT9/ ENSMUS 16898 0.12817 0.23 11 188.463 78.3556 154.463 1130.73 0 0 0 0 64.1764 111.141
ribosomal 41.2/IPI00 USE Q3V2B9/ G0000004 0308 82 1174 277 0366 1879 0581
protein S2 626139.2/ Q9DC49/ 4533
IPI003801 P25444
30.2/IPI00
988008.1
Steroidogen Star TP mitocho IPI003118 STAR_M P51557 ENSMUS 20845 0.13137 0.33 1 251.081 130.884 204.886 149.610 192.296 0 0 0 306.620 0
ic acute ndria 22.1 OUSE G0000003 9419 2882 1957 1562 474 7565 1085
regulatory 1574
protein,
mitochondr
ial
Transmemb Tmem1 TM IPI004030 TM175_ Q8BHJ8 ENSMUS 72392 0.13137 0.33 1 251.081 130.884 204.886 149.610 192.296 0 0 0 306.620 0
rane protein 75 52.1 MOUSE G0000001 9419 2882 1957 1562 474 7565 1085
175 3495
EH Ehd2 TP muscle IPI004029 EHD2_M Q8BH64/ ENSMUS 259300 0.13394 0.51 22 1011.77 894.450 1245.34 0 799.888 520.968 232.114 681.441 744.623 343.339
domain- 68.1/IPI00 OUSE Q8R2X0 G0000007 3719 8441 636 5303 3562 2907 4371 5652 128 5366
containing 857483.2 4364
protein 2
Selenium- Selenbp TP IPI009895 SBP2_M F6VSJ4/G ENSMUS 20342 0.13660 1.19 10 0 317.683 0 0 193.630 237.232 130.954 0 599.726 253.967
binding 2 87.1/IPI01 OUSE 3UWK0 G0000006 1384 3064 2254 5856 3938 6765 7322
protein 2 027244.1 8877
Filamin-A- Filip1 CS IPI007564 FLIP1_M Q059P4 ENSMUS 0.13879 0.39 6 679.126 247.286 424.233 0 347.716 0 256.916 234.856 164.394 0
interacting 00.2 OUSE G0000003 1738 829 1252 1606 3263 7756 1237 7126
protein 1 4898
Long-chain Acadl ENZ mitocho IPI008945 ACADL_ Q9DB83/ ENSMUS 11363 0.13896 0.72 28 5247.05 4733.73 8060.23 7099.53 2160.06 3705.35 2282.66 5618.72 5884.72 2290.19
specific ndria 88.1/IPI00 MOUSE P51174 G0000002 4862 3193 6875 3228 6295 9666 1239 7654 1896 3558 0039

- 26 -
acyl-CoA 119114.2 6003
dehydrogen
ase,
mitochondr
ial
Uridine Upp1 ENZ IPI009871 UPP1_M E9Q391/ ENSMUS 22271 0.14033 0.56 2 0 70.0376 87.1171 161.871 0 53.7013 0 0 65.1361 0
phosphoryl 06.1/IPI00 OUSE Q5SUC8 G0000002 1851 9159 3864 5026 0967 5768
ase 1 323353.3 0407
Triosephos Tpi1 ENZ IPI004678 TPIS_MO P17751 ENSMUS 21991 0.14133 1.47 10 244.898 298.746 418.093 202.404 489.259 682.950 226.801 398.122 278.633 852.058
phate 33.6/IPI00 USE G0000002 4389 8929 9581 6854 212 9956 2213 9414 2371 155 5207
isomerase 988063.1 3456
Nebulin Neb CS muscle IPI007202 E9Q1W3_ A2AQA9/ ENSMUS 17996 0.14157 11.68 57 0 0 0 0 114.278 540.391 0 0 0 2128.37
38.2/IPI00 MOUSE E9Q2J0 G0000002 2134 9788 8346 3472
379424.8 6950
Myosin-6 Myh6 CS muscle IPI001294 MYH6_M Q02566 ENSMUS 17888 0.14245 3.64 58 613.550 990.179 5884.92 0 0 6180.80 3975.44 3818.78 540.065 12749.3
04.1 OUSE G0000004 6697 9284 9165 2748 448 0653 5227 6234 8766
0752
40S Rps3 RIB IPI001345 RS3_MO Q3UK56/ ENSMUS 27050 0.14519 0.32 7 220.979 68.9298 126.509 524.969 0 48.2870 45.8032 140.820 57.2493 86.9435
ribosomal 99.1/IPI00 USE D3YV43 G0000003 6059 9693 4407 5695 6097 9265 267 8707 3951 4564
protein S3 856866.1 0744
Periaxin Prx CS IPI004699 PRAX_M O55103/Q ENSMUS 19153 0.14911 3.34 7 743.740 1334.71 118.635 620.142 4266.62 7370.67 14344.1 796.948 619.458 547.217
52.2/IPI00 OUSE 6NVF7 G0000005 3129 2592 6997 9369 256 0705 303 2756 0354 3241 6502
762284.1 3198
Myomegali Pde4dip CS IPI003362 MYOME Q80YT7 ENSMUS 83679 0.15021 3.89 6 112.038 31.9304 158.188 231.917 0 0 674.436 0 111.550 773.066
n 48.2/IPI00 _MOUSE G0000003 7144 3157 8094 6687 1647 1317 7647 2002
974941.1 8170
KN motif Kank1 DEV IPI009180 E9Q238_ A7MCX9/ ENSMUS 107351 0.15026 0.46 7 546.922 373.408 0 619.605 0 0 0 160.806 352.721 189.120
and ankyrin 63.1/IPI00 MOUSE E9Q238 G0000003 2898 5197 2286 0024 6314 0725 7829
repeat 460667.2 2702
domain-
containing
protein 1
60S Rpl23a RIB IPI009875 RL23A_ P62751 ENSMUS 10004375 0.15043 0.14 4 34.3551 0 16.1944 203.204 0 14.6226 9.49836 0 0 0
ribosomal 02.1/IPI00 MOUSE G0000006 5 6367 8838 4247 4935 9442 3404
protein 989782.1 3556|ENS
L23a-like MUSG00
00005854
6
Carnitine Cpt2 ENZ mitocho IPI001314 CPT2_M P52825 ENSMUS 12896 0.15079 0.74 12 444.800 431.198 411.687 466.651 0 275.402 81.9029 364.842 391.854 187.867
O- ndria 24.4 OUSE G0000002 3651 8633 2742 751 437 0051 4309 7579 5727 8318
palmitoyltr 8607
ansferase 2,
mitochondr
ial
Dihydrolip Dlat ENZ mitocho IPI001536 ODP2_M Q8BMF4 ENSMUS 235339 0.15079 0.58 6 876.706 1290.14 922.877 673.538 0 440.262 247.954 556.169 645.291 283.114
oyllysine- ndria 60.4 OUSE G0000000 3651 4211 6362 1933 5661 4156 4295 8712 2587 0147
residue 0168
acetyltransf
erase
component
of pyruvate
dehydrogen
ase
complex,
mitochondr
ial

- 27 -
Mitochondr Ucp1 TP mitocho IPI002232 UCP1_M P12242 ENSMUS 22227 0.15079 0.56 5 2014.51 2641.66 1635.82 1161.55 429.306 779.165 270.598 1155.28 1964.60 269.441
ial brown ndria 36.5 OUSE G0000003 3651 2013 5156 8603 8388 8846 7188 034 7471 2482 3739
fat 1710
uncoupling
protein 1
Ski Ski MOD muscle IPI006228 SKI_MO Q9CTE9 0.15079 0.57 2 76.9855 82.5040 60.6593 66.9661 170.436 55.5847 16.9559 71.4314 79.4552 39.3810
oncogene 96.2 USE 3651 1357 2303 8165 0535 6962 6758 7974 8326 0226 7837
Apolipopro Apoa2 TP secreted IPI001113 APOA2_ P09813 11807 0.15079 0.69 1 348.456 259.383 186.687 200.962 243.572 149.742 142.042 188.471 281.530 97.9090
tein A-II 15.1 MOUSE 3651 9329 8335 311 1901 2879 5828 8142 78 6256 5795
Collagen Col1a1 CS secreted IPI003298 CO1A1_ P11087 ENSMUS 12842 0.15079 0.58 43 10041.1 7328.80 8196.09 7453.06 5953.15 1916.01 838.704 4505.23 8511.48 6924.69
alpha-1(I) 72.1 MOUSE G0000000 3651 3914 824 3032 0862 1645 932 9684 7227 4799 7548
chain 1506
Collagen Col6a3 CS secreted IPI008307 F6XLB2_ F6XLB2 ENSMUS 0.15079 0.64 16 704.428 381.326 884.894 322.123 588.390 254.649 252.464 613.917 465.868 244.733
alpha-3(VI) 49.4 MOUSE G0000004 3651 2042 6458 7044 9546 0245 987 2418 724 8476 7678
chain 8126
Fibronectin Fn1 CS secreted IPI009747 FINC_M B9EHT6 ENSMUS 0.15079 0.43 17 330.203 216.893 338.265 0 241.050 77.5928 88.7859 143.285 95.2237 78.0804
12.1 OUSE G0000002 3651 3394 9379 134 8947 078 2319 6307 1269 3761
6193
Myosin-9 Myh9 CS IPI001231 MYH9_M Q8VDD5 ENSMUS 17886 0.15079 0.64 34 1328.84 1667.19 1878.66 847.626 1083.02 1048.79 436.569 1198.02 1109.64 536.064
81.4 OUSE G0000002 3651 8273 9585 3862 9276 6736 4464 5599 2534 854 0124
2443
L-lactate Ldhb ENZ IPI002295 LDHB_M P16125 ENSMUS 16832 0.15079 1.18 8 848.030 828.589 866.731 651.465 652.003 1112.40 439.319 1021.02 941.385 1037.42
dehydrogen 10.5 OUSE G0000003 3651 3013 258 3392 5369 1376 9358 7344 4217 6305 6572
ase B chain 0246
Annexin Anxa6 MOD IPI003102 ANXA6_ Q8CEX0 ENSMUS 11749 0.15079 0.63 18 613.817 634.020 445.927 160.839 349.424 280.203 51.0767 341.605 277.777 430.791
A6 40.4 MOUSE G0000001 3651 2792 1498 649 4198 9208 6528 2133 4758 8789 6088
8340
Malate Mdh1 ENZ IPI003363 MDHC_ P14152 ENSMUS 17449 0.15079 1.32 6 605.205 945.356 846.970 980.234 1122.11 1356.89 648.133 1128.73 1015.04 1808.97
dehydrogen 24.11 MOUSE G0000002 3651 4046 0174 8614 0283 938 293 4127 0421 8559 8838
ase, 0321
cytoplasmic
Protein Gm603 UK IPI009872 E9Q101_ E9Q101 ENSMUS 547347 0.15079 1.82 1 199.212 450.381 298.022 201.572 155.507 514.846 288.283 315.361 254.693 1006.38
Gm6034 4 22.1 MOUSE G0000007 3651 2289 9063 5056 3172 6989 5371 594 1941 9438 5293
3407
Short-chain Acads ENZ mitocho IPI008857 ACADS_ F6RAZ3/ ENSMUS 11409 0.15618 0.73 10 1178.05 976.999 1216.97 918.132 467.819 509.399 408.328 987.572 1297.91 285.678
specific ndria 62.1/IPI00 MOUSE Q07417 G0000002 3755 0013 4203 5418 3489 4927 8988 3492 3605 132 0251
acyl-CoA 116591.2 9545
dehydrogen
ase,
mitochondr
ial
Lamin-B2 Lmnb2 CS IPI001261 LMNB2_ P21619 ENSMUS 16907 0.15649 1.14 5 422.430 495.229 296.453 0 0 0 0 0 463.185 0
91.5/IPI00 MOUSE G0000006 6807 2191 215 747 7546
113886.1 2075
LETM1 Letm1 CS mitocho IPI001311 LETM1_ Q9Z2I0 ENSMUS 56384 0.15793 0.04 5 737.953 885.368 648.671 0 0 0 0 95.8590 0 0
and EF- ndria 77.1 MOUSE G0000000 9311 08 5311 2897 4972
hand 5299
domain-
containing
protein 1,
mitochondr
ial
NAD(P) Nnt ENZ mitocho IPI003099 NNTM_ Q922E1 0.15793 46.07 12 0 0 29.6287 0 0 227.828 166.818 0 0 970.213
transhydrog ndria 64.3 MOUSE 9311 429 4546 5755 1825
enase,
mitochondr

- 28 -
ial
Carbonyl Cbr4 ENZ mitocho IPI008955 CBR4_M D3Z6C4 ENSMUS 234309 0.15793 3.49 3 0 66.7300 0 0 0 67.9647 0 87.4068 77.4359 0
reductase ndria 35.1 OUSE G0000003 9311 2889 9816 1761 8923
family 1641
member 4
Collagen Col4a5 CS secreted IPI001134 Q63ZW6_ Q63ZW6 ENSMUS 12830 0.15793 0.26 4 428.656 277.436 0 0 323.927 0 0 0 270.646 0
alpha-5(IV) 77.5 MOUSE G0000003 9311 411 4342 4557 4177
chain 1274
Dimethylan Fmo1 ENZ IPI001164 FMO1_M P50285 ENSMUS 14261 0.15793 0.04 6 165.035 0 95.4781 105.241 0 0 0 0 13.3295 0
iline 32.1 OUSE G0000004 9311 0473 3747 5623 476
monooxyge 0181
nase [N-
oxide-
forming] 1
SH3 Sh3bgrl UK IPI001222 SH3L1_M Q9JJU8 ENSMUS 56726 0.15793 0.27 1 31.2634 27.4745 30.3879 0 0 0 0 24.1741 0 0
domain- 65.1 OUSE G0000003 9311 4964 8691 8022 1429
binding 1246
glutamic
acid-rich-
like protein
Proline-rich Prr14 UK IPI001231 PRR14_M Q7TPN9 ENSMUS 233895 0.15793 27.73 2 0 65.2315 0 0 0 580.351 154.504 0 0 1074.13
protein 14 91.2 OUSE G0000003 9311 6331 0843 3427 1946
0822
Annexin Anxa1 CS IPI002303 ANXA1_ P10107 ENSMUS 16952 0.15793 0.22 3 112.990 82.6576 136.698 0 0 0 0 0 72.9593 0
A1 95.5 MOUSE G0000002 9311 8305 1472 7596 84
4659
Protein BC0510 ENZ IPI002654 Q80W26_ Q80W26 ENSMUS 229688 0.15793 8.91 1 322.894 0 0 0 0 1008.64 372.884 0 1496.41 0
BC051070 70 10.1 MOUSE G0000002 9311 619 7519 2561 0515
7902
N-myc Mycn TF IPI003093 MYCN_ P03966 ENSMUS 18109 0.15793 0.26 1 173.265 226.149 179.995 0 0 0 0 148.074 0 0
proto- 97.3 MOUSE G0000003 9311 6593 6731 2457 3983
oncogene 7169
protein
Urea Slc14a2 TP IPI004109 UT2_MO Q8R4T9 ENSMUS 27411 0.15793 0.11 1 240.423 0 262.641 0 181.389 77.0601 0 0 0 0
transporter 60.2 USE G0000002 9311 048 7717 6008 6768
2 4552
CDK5 Cdk5ra CS IPI004538 CK5P2_ Q8K389 ENSMUS 214444 0.15793 0.08 2 86.9076 254.327 95.2490 0 0 0 35.4175 0 0 0
regulatory p2 07.3 MOUSE G0000003 9311 8223 859 4147 0923
subunit- 9298
associated
protein 2
Bromodom Brd2 DEV IPI004604 BRD2_M Q7JJ13 ENSMUS 14312 0.15793 0.17 2 161.856 519.403 139.854 0 0 0 0 135.972 0 0
ain- 42.4 OUSE G0000002 9311 0836 3875 2646 0748
containing 4335
protein 2
Hormone- Lipe ENZ IPI004694 LIPS_MO P54310 ENSMUS 16890 0.15793 0.11 7 283.373 295.321 189.590 0 0 88.3419 0 0 0 0
sensitive 16.3 USE G0000000 9311 6704 8847 0035 2254
lipase 3123
WD repeat, Wdsub1 UK IPI004699 WSDU1_ A2AUX8 ENSMUS 72137 0.15793 0.11 1 151.842 138.911 0 224.389 0 0 56.0285 0 0 0
SAM and 02.3 MOUSE G0000002 9311 1314 2453 8512 472
U-box 6988
domain-
containing
protein 1
Histone Hdac6 TF IPI007758 HDAC6_ Q3UG37 ENSMUS 15185 0.15793 10.12 1 0 0 99.2952 0 0 251.810 220.340 0 0 533.060
deacetylase 30.1 MOUSE G0000003 9311 5481 7148 8998 8421

- 29 -
6 1161
Rho Arhgef6 MOD IPI007762 ARHG6_ A2AFJ8 ENSMUS 73341 0.15793 10.82 1 0 0 60.8081 0 0 198.263 119.040 0 0 340.491
guanine 82.1 MOUSE G0000003 9311 247 0141 5838 2904
nucleotide 1133
exchange
factor 6
Protein S100a1 DEV IPI009872 S10AB_ D3YU66 ENSMUS 20195 0.15793 0.20 2 71.6681 68.8581 91.7826 0 0 0 0 0 46.7347 0
S100-A11 1 38.1 MOUSE G0000002 9311 0837 2251 8006 0263
7907
NADP- Me1 ENZ IPI009879 MAOX_ Q3TQW1 ENSMUS 17436 0.15793 0.09 6 420.150 278.378 0 0 178.564 0 0 0 0 80.7326
dependent 14.1 MOUSE G0000003 9311 6552 5937 0738 3879
malic 2418
enzyme
Heat shock Hsf3 TF IPI009894 HSF3_M Q8BL67 ENSMUS 0.15793 0.08 1 189.072 194.112 0 0 118.419 0 0 0 0 38.9466
factor 68.1 OUSE G0000004 9311 8776 8648 0782 5965
protein 3 5802
Leucine- Lrrk1 ENZ IPI010083 LRRK1_ E9QNM4 ENSMUS 233328 0.15793 3.89 3 0 0 133.102 0 0 148.487 0 233.047 135.653 0
rich repeat 65.1 MOUSE G0000001 9311 1925 6387 0129 443
serine/threo 5133
nine-
protein
kinase 1
Myosin Mprip CS muscle IPI006481 MPRIP_ Q8CHC7 ENSMUS 26936 0.16123 0.27 4 77.0865 312.570 556.371 0 667.015 0 0 285.929 150.363 0
phosphatas 00.2 MOUSE G0000000 7592 6026 0019 2744 7668 0319 9857
e Rho- 5417
interacting
protein
Serpin H1 Serpinh CHA IPI001147 SERPH_ P19324 ENSMUS 12406 0.16123 0.35 9 309.185 320.724 179.619 0 130.560 124.349 0 207.574 0 0
1 33.2 MOUSE G0000007 7592 3496 1457 7216 2163 1615 9694
0436
Nucleoside Nme2 ENZ IPI009902 NDKB_M E9PZF0/ ENSMUS 18103 0.16252 0.93 13 0 0 509.138 0 0 700.683 206.142 518.825 0 0
diphosphate 46.1/IPI00 OUSE Q01768 G0000009 5932 2535 1 3338 0338
kinase B 127417.1 1228|ENS
MUSG00
00002085
7
ATP Atp5a1 TP mitocho IPI008574 ATPA_M D3Z6F5/ ENSMUS 11946 0.16644 1.39 32 2331.08 2877.85 3470.28 2263.00 1895.32 3376.31 2169.82 2868.10 2406.26 7003.01
synthase ndria 39.1/IPI00 OUSE Q03265 G0000002 8656 6756 5151 5342 1387 8397 3113 2961 2095 1997 2099
subunit 130280.1 5428
alpha,
mitochondr
ial
Peroxiredo Prdx6 ENZ IPI007540 PRDX6_ D3Z0Y2/ ENSMUS 11758 0.16782 0.29 7 142.814 75.7552 83.5961 571.173 0 52.3677 39.7632 74.9612 81.7383 67.8377
xin-6 71.1/IPI00 MOUSE O08709 G0000002 7374 5402 7958 73 5491 9029 0368 9393 0787 2811
555059.2 6701
Collagen Col18a1 CS secreted IPI002848 COIA1_ P39061 ENSMUS 12822 0.16811 0.41 9 149.524 181.389 428.688 0 0 57.6527 0 181.881 69.5379 0
alpha- 16.4/IPI00 MOUSE G0000000 6991 3439 3047 2525 6922 9879 0655
1(XVIII) 230616.2 1435
chain
Basigin Bsg DEV IPI001138 BASI_M P18572 ENSMUS 12215 0.17321 0.62 3 162.120 184.785 210.741 120.676 0 92.5003 81.8044 94.7486 150.206 0
69.1 OUSE G0000002 7113 4415 9091 0027 7598 4209 1805 3545 3673
3175
Low- Lrp11 TM IPI009188 LRP11_M D3Z2B1/ ENSMUS 237253 0.17362 0.30 3 0 0 394.640 0 87.2712 71.5559 0 0 0 0
density 08.1/IPI00 OUSE D3Z3A7 G0000001 5431 758 358 165
lipoprotein 918908.1 9796
receptor-

- 30 -
related
protein 11
Interferon- Gbp1 MOD IPI001246 GBP1_M Q01514 0.17455 1.20 4 410.029 834.652 0 820.065 0 0 0 0 828.682 0
induced 75.1/IPI00 OUSE 26 6705 8428 7006 9667
guanylate- 985967.1
binding
protein 1
Zinc finger Zfyve26 CS IPI005549 ZFY26_M Q5DU37 ENSMUS 211978 0.17607 0.16 5 69.2084 581.350 0 0 0 0 51.7732 0 0 0
FYVE 20.5/IPI00 OUSE G0000006 0385 3644 005 247
domain- 881470.1 6440
containing
protein 26
Trichohyali Tchh SCA HAIR? IPI004579 Q3V203_ Q3V203 0.17971 1000.00 2 0 0 0 0 0 0 0 17.7541 59.6322 0
n 39.5 MOUSE 2495 4818 3856
NADH Ndufb1 TP mitocho IPI001142 NDUBB_ O09111 ENSMUS 104130 0.17971 0.00 2 90.8784 102.966 0 0 0 0 0 0 0 0
dehydrogen 1 ndria 46.2 MOUSE G0000003 2495 8091 0572
ase 1059
[ubiquinone
] 1 beta
subcomplex
subunit 11,
mitochondr
ial;
AltName:
Full=Comp
lex I-ESSS;
Short=CI-
ESSS;
AltName:
Full=NAD
H-
ubiquinone
oxidoreduct
ase ESSS
subunit;
AltName:
Full=Neuro
nal protein
15.6;
Short=Np1
5.6;
Short=p15.
6; Flags:
Precursor;
Brain Brp44l UK mitocho IPI001242 BR44L_ P63030 ENSMUS 55951 0.17971 0.00 4 580.147 765.026 0 0 0 0 0 0 0 0
protein 44- ndria 92.1 MOUSE G0000002 2495 158 0878
like protein 3861
Cytochrom Uqcrh TP mitocho IPI001295 QCR6_M P99028 ENSMUS 66576 0.17971 1000.00 1 0 0 0 0 0 37.7937 0 19.1946 0 0
e b-c1 ndria 16.1 OUSE G0000006 2495 6324 6697
complex 3882
subunit 6,
mitochondr
ial
Cytochrom Mtco3 TP mitocho IPI001311 COX3_M P00416 0.17971 1000.00 1 0 0 0 0 0 34.1305 0 36.5451 0 0
e c oxidase ndria 93.1 OUSE 2495 8401 5714
subunit 3
ATP Atp5l TP mitocho IPI001333 ATP5L_ Q9CPQ8 ENSMUS 27425 0.17971 1000.00 2 0 0 0 0 0 0 85.2225 0 0 173.410

- 31 -
synthase ndria 42.1 MOUSE G0000003 2495 1646 4033
subunit g, 8717
mitochondr
ial
Calcium- Slc25a1 TP mitocho IPI003081 CMC1_M Q8BH59 ENSMUS 78830 0.17971 1000.00 4 0 0 0 0 0 75.7356 0 0 0 248.357
binding 2 ndria 62.3 OUSE G0000002 2495 6793 7246
mitochondr 7010
ial carrier
protein
Aralar1
Serine Shmt2 ENZ mitocho IPI004540 Q99K87_ Q99K87 0.17971 0.00 2 0 78.4851 90.0833 0 0 0 0 0 0 0
hydroxymet ndria 08.1 MOUSE 2495 8881 8401
hyltransfera
se,
mitochondr
ial
Thiosulfate Tst ENZ mitocho IPI007621 THTR_M D3YYT7 ENSMUS 22117 0.17971 0.00 2 23.0262 0 20.8163 0 0 0 0 0 0 0
sulfurtransf ndria 28.2 OUSE G0000004 2495 6624 7479
erase 4986
Putative Iba57 ENZ mitocho IPI008567 CAF17_ B2FDE8/ ENSMUS 216792 0.17971 0.73 2 157.795 0 170.989 0 0 88.7835 0 150.715 0 0
transferase ndria 11.1/IPI00 MOUSE Q8CAK1 G0000004 2495 7589 6794 3629 5765
CAF17 228106.3 9287
homolog,
mitochondr
ial
Monofuncti Mthfd1l ENZ mitocho IPI008758 C1TM_M Q3V3R1 ENSMUS 270685 0.17971 1000.00 1 0 0 0 0 0 0 157.512 0 0 366.814
onal C1- ndria 33.2 OUSE G0000004 2495 6528 4037
tetrahydrof 0675
olate
synthase,
mitochondr
ial
PDZ and Pdlim3 CS muscle IPI001163 PDLI3_M O70209 ENSMUS 53318 0.17971 0.00 1 0 37.9227 65.3076 0 0 0 0 0 0 0
LIM 47.1 OUSE G0000003 2495 313 4441
domain 1636
protein 3
Myotilin Myot CS muscle IPI001205 MYOTI_ Q9JIF9 ENSMUS 58916 0.17971 1000.00 4 0 0 0 0 0 47.6854 0 0 0 253.306
08.1 MOUSE G0000002 2495 1942 1478
4471
Cofilin-2 Cfl2 CS muscle IPI002661 COF2_M P45591 ENSMUS 12632 0.17971 1000.00 4 0 0 0 0 0 196.594 0 0 0 327.224
88.6 OUSE G0000006 2495 2396 6472
2929
6- Pfkm ENZ muscle IPI003315 K6PF_M O35514 ENSMUS 18642 0.17971 1000.00 6 0 0 0 0 0 195.457 0 0 0 96.8434
phosphofru 41.5 OUSE G0000003 2495 1287 9436
ctokinase, 3065
muscle type
Glycogen Pygm ENZ muscle IPI008310 PYGM_M E9PUM3 ENSMUS 19309 0.17971 1000.00 16 0 0 0 0 0 868.838 0 0 0 1105.19
phosphoryl 57.1 OUSE G0000003 2495 8084 2215
ase, muscle 2648
form
Calsequestr Casq1 TP muscle IPI010231 CASQ1_ Q925P6 ENSMUS 12372 0.17971 1000.00 1 0 0 0 0 0 144.252 0 0 0 176.352
in-1 91.1 MOUSE G0000000 2495 4337 2052
7122
Nidogen-1 Nid1 CS secreted IPI001117 NID1_M P10493 ENSMUS 18073 0.17971 0.00 2 66.9833 0 26.8972 0 0 0 0 0 0 0
93.2 OUSE G0000000 2495 1813 7933
5397

- 32 -
Alpha-2- Serpinf INH secreted IPI001189 A2AP_M Q61247 ENSMUS 18816 0.17971 0.00 3 72.4763 72.7462 0 0 0 0 0 0 0 0
antiplasmin 2 24.1 OUSE G0000003 2495 4164 0926
8224
Serine Serpina INH secreted IPI001280 SPA3C_ P29621 ENSMUS 16625 0.17971 1000.00 4 0 0 0 0 0 810.574 0 0 0 767.798
protease 3c 76.1 MOUSE G0000006 2495 7239 4012
inhibitor 6361
A3C
Fibroblast Fgf2 SIG secreted IPI001326 FGF2_M P15655 ENSMUS 14173 0.17971 1000.00 1 0 0 0 0 0 49.4187 0 0 78.9415 0
growth 09.1 OUSE G0000003 2495 8846 6269
factor 2 7225
Collagen Col4a3 CS secreted IPI001379 CO4A3_ Q9QZS0 ENSMUS 12828 0.17971 1000.00 1 0 0 0 0 0 115.812 103.264 0 0 0
alpha-3(IV) 38.7 MOUSE G0000007 2495 7215 6764
chain 9465
UPF0378 Kiaa010 UK secreted IPI002245 K0100_M Q5SYL3 ENSMUS 72503 0.17971 1000.00 2 0 0 0 0 0 30.8553 0 0 0 273.951
protein 0 19.6 OUSE G0000001 2495 9293 386
KIAA0100 0277
SCO- Sspo CS secreted IPI002294 SSPO_M Q8CG65 ENSMUS 0.17971 1000.00 2 0 0 0 0 0 81.3933 302.197 0 0 0
spondin 24.6 OUSE G0000002 2495 7925 9815
9797
Fibrillin-1 Fbn1 CS secreted IPI003385 FBN1_M Q99L19 0.17971 0.00 4 168.161 0 198.186 0 0 0 0 0 0 0
65.2 OUSE 2495 4958 4758
Matrix Mepe CS secreted IPI006521 Q3TYV1_ Q3TYV1 0.17971 0.00 1 0 0 116.005 0 180.071 0 0 0 0 0
extracellula 95.1 MOUSE 2495 5692 8654
r
phosphogly
coprotein
Major Mup8 TP secreted IPI008758 MUP8_M P04938 0.17971 0.00 4 174.816 1368.62 0 0 0 0 0 0 0 0
urinary 54.3 OUSE 2495 3494 5662
proteins 11
and 8
Matrix Mmp21 ENZ secreted IPI008802 MMP21_ Q3KP74 ENSMUS 214766 0.17971 1000.00 1 0 0 0 0 0 71.5559 67.2570 0 0 0
metalloprot 40.1 MOUSE G0000003 2495 165 573
einase-21 0981
C-type Clec18a RCP secreted IPI008892 CL18A_ Q7TSQ1 ENSMUS 0.17971 1000.00 2 0 0 0 0 0 0 0 0 52.4749 63.5686
lectin 89.1 MOUSE G0000003 2495 9709 436
domain 3633
family 18
member A
Major Mup1 TP secreted IPI009384 MUP1_M A2CEK9 ENSMUS 10003905 0.17971 0.00 1 0 0 116.443 119.586 0 0 0 0 0 0
urinary 84.1 OUSE G0000007 4 2495 4114 2584
protein 1 8683|ENS
MUSG00
00007383
9
DNA Mcm3 CC IPI001083 MCM3_ P25206 ENSMUS 17215 0.17971 0.00 2 0 44.6251 0 643.256 0 0 0 0 0 0
replication 38.1 MOUSE G0000004 2495 6406 9041
licensing 1859
factor
MCM3
S- Esd ENZ IPI001091 ESTD_M Q9R0P3 ENSMUS 13885 0.17971 0.00 2 78.2887 49.3775 0 0 0 0 0 0 0 0
formylgluta 42.4 OUSE G0000002 2495 9314 6582
thione 1996
hydrolase
Chromoso Kif4 CS IPI001094 KIF4_MO P33174 ENSMUS 16571 0.17971 1000.00 2 0 0 0 0 0 105.196 32.2495 0 0 0
me- 19.2 USE G0000003 2495 9882 4663
associated 4311

- 33 -
kinesin
KIF4
Dual Dusp3 ENZ IPI001109 DUS3_M Q9D7X3 ENSMUS 72349 0.17971 0.00 1 0 0 65.4595 0 102.912 0 0 0 0 0
specificity 90.1 OUSE G0000000 2495 9209 2339
protein 3518
phosphatas
e3
ATP- Abca1 TP IPI001126 ABCA1_ P41233 ENSMUS 11303 0.17971 1000.00 1 0 0 0 0 0 634.869 0 260.483 0 0
binding 14.3 MOUSE G0000001 2495 658 3313
cassette 5243
sub-family
A member
1
Delta- Alad ENZ IPI001127 HEM2_M P10518 ENSMUS 17025 0.17971 0.00 1 0 143.829 0 39.8524 0 0 0 0 0 0
aminolevuli 19.1 OUSE G0000002 2495 3305 4334
nic acid 8393
dehydratase
Glycylpepti Nmt2 ENZ IPI001172 NMT2_M O70311 ENSMUS 18108 0.17971 1000.00 1 0 0 0 0 0 0 0 95.9557 0 555.402
de N- 52.1 OUSE G0000002 2495 7374 7824
tetradecano 6643
yltransferas
e2
Heterogene Hnrnpa TF IPI001172 ROAA_M Q99020 ENSMUS 15384 0.17971 0.00 3 0 0 0 433.601 320.288 0 0 0 0 0
ous nuclear b 88.3 OUSE G0000002 2495 1899 1701
ribonucleop 0358
rotein A/B
Protein Ptch1 RCP IPI001177 PTC1_M Q61115 ENSMUS 19206 0.17971 1000.00 1 0 0 0 0 0 328.059 134.213 0 0 0
patched 58.1 OUSE G0000002 2495 5518 5544
homolog 1 1466
Putative Mov10l ENZ IPI001180 M10L1_ Q99MV5 83456 0.17971 1000.00 2 0 0 0 0 0 0 54.6259 0 248.115 0
helicase 1 99.2 MOUSE 2495 4975 0054
Mov10l1
Staphyloco Snd1 TF IPI001231 SND1_M Q78PY7 ENSMUS 56463 0.17971 0.00 2 1395.75 0 0 0 64.7646 0 0 0 0 0
ccal 29.1 OUSE G0000000 2495 0231 4293
nuclease 1424
domain-
containing
protein 1
Thyroid Thrsp TF IPI001234 THRSP_ Q62264 ENSMUS 21835 0.17971 0.00 1 81.6400 77.9305 0 0 0 0 0 0 0 0
hormone- 49.1 MOUSE G0000003 2495 8484 6871
inducible 5686
hepatic
protein
Hydroxyaci Hao1 ENZ IPI001237 HAOX1_ Q9WU19 ENSMUS 15112 0.17971 0.00 1 0 26.9347 27.1696 0 0 0 0 0 0 0
d oxidase 1 50.1 MOUSE G0000002 2495 0868 4539
7261
Cyclic Creb3 TF IPI001260 CREB3_ Q61817 0.17971 0.00 1 25.5998 29.7705 0 0 0 0 0 0 0 0
AMP- 97.2 MOUSE 2495 1659 0588
responsive
element-
binding
protein 3
Prostacycli Ptgis ENZ IPI001264 PTGIS_M O35074 ENSMUS 19223 0.17971 0.00 2 19.4153 33.0665 0 0 0 0 0 0 0 0
n synthase 98.1 OUSE G0000001 2495 4573 9662
7969
GDP- Pofut2 ENZ IPI001283 OFUT2_ Q8VHI3 ENSMUS 80294 0.17971 0.00 1 0 64.8249 69.4022 0 0 0 0 0 0 0

- 34 -
fucose 36.3 MOUSE G0000002 2495 0238 0868
protein O- 0260
fucosyltran
sferase 2
Coiled-coil Ccdc65 UK IPI001283 CCD65_ Q8VHI7 ENSMUS 105833 0.17971 1000.00 2 0 0 0 0 0 365.089 124.618 0 0 0
domain- 42.2 MOUSE G0000000 2495 5944 4117
containing 3354
protein 65
Stereocilin Strc CS IPI001295 STRC_M Q8VIM6 ENSMUS 140476 0.17971 1000.00 1 0 0 0 0 0 0 0 320.258 0 292.841
47.2 OUSE G0000003 2495 5265 0945
3498
60S acidic Rplp0 RIB IPI001308 RLA0_M O89073 ENSMUS 11837 0.17971 0.00 1 36.2158 0 0 127.232 0 0 0 0 0 0
ribosomal 30.1 OUSE G0000006 2495 2361 8702
protein P0 7274
(Fragment)
F-box only Fbxo5 CC IPI001320 FBX5_M Q7TSG3 ENSMUS 67141 0.17971 1000.00 2 0 0 0 0 0 152.728 0 123.568 0 0
protein 5 13.2 OUSE G0000001 2495 36 4723
9773
Mediator of Med4 TF IPI001323 MED4_M Q9CQA5 ENSMUS 67381 0.17971 0.00 1 94.0068 0 115.481 0 0 0 0 0 0 0
RNA 28.3 OUSE G0000002 2495 0226 4167
polymerase 2109
II
transcriptio
n subunit 4
Protein Rabl2 SIG IPI001330 E9Q9T7_ Q9D133 ENSMUS 0.17971 1000.00 1 0 0 0 0 0 208.852 0 0 0 270.999
Rabl2 63.2 MOUSE G0000002 2495 7697 3722
(RAB, 2621
member of
RAS
oncogene
family-like
2B)
Developme Drg2 DEV IPI001348 DRG2_M Q9QXB9 ENSMUS 13495 0.17971 0.00 1 0 165.160 0 170.184 0 0 0 0 0 0
ntally- 20.1 OUSE G0000002 2495 7594 2016
regulated 0537
GTP-
binding
protein 2
Vitamin K- Ggcx ENZ IPI001360 VKGC_M Q3TME3 ENSMUS 56316 0.17971 1000.00 2 0 0 0 0 0 142.358 0 0 0 463.824
dependent 12.1 OUSE G0000005 2495 253 7273
gamma- 3460
carboxylase
MCG11388 493340 UK IPI001371 Q9D4D3_ Q9D4D3 ENSMUS 74426 0.17971 1000.00 1 0 0 0 0 0 0 0 119.899 143.324 0
2 2D24Ri 14.1 MOUSE G0000002 2495 4961 3379
k 5961
Inactive Usp44 UK IPI002247 UBP44_ Q8C2S0 ENSMUS 327799 0.17971 1000.00 1 0 0 0 0 0 52.7949 29.6230 0 0 0
ubiquitin 57.2 MOUSE G0000002 2495 912 4228
carboxyl- 0020
terminal
hydrolase
44
Protein D83004 UK IPI002250 Q8C3F6_ Q8C3F6 ENSMUS 0.17971 0.00 1 45.4242 0 50.4628 0 0 0 0 0 0 0
D830046C 6C22Ri 17.1 MOUSE G0000002 2495 0564 0027
22Rik k 1206
Glucose-6- G6pdx ENZ IPI002283 G6PD1_ Q00612 ENSMUS 14381 0.17971 0.00 4 177.525 0 92.5622 0 0 0 0 0 0 0
phosphate 85.5 MOUSE G0000003 2495 5374 4911

- 35 -
1- 1400
dehydrogen
ase X
Neurexin- Nrxn3 CS IPI002286 NRX3A_ Q6P9K9 ENSMUS 18191 0.17971 1000.00 2 0 0 0 0 0 319.714 0 0 0 321.533
3-alpha 80.3 MOUSE G0000006 2495 3561 8608
6392
Histone- Wbp7 ENZ IPI002296 MLL4_M O08550 ENSMUS 75410 0.17971 1000.00 2 0 0 0 0 0 278.342 0 0 0 111.156
lysine N- 51.7 OUSE G0000000 2495 2366 8468
methyltrans 6307
ferase
MLL4
Adenomato Apc SIG IPI002298 APC_MO Q61315 0.17971 0.00 4 776.339 290.849 0 0 0 0 0 0 0 0
us 94.1 USE 2495 3576 5289
polyposis
coli protein
Estrogen Esr2 TF IPI002302 ESR2_M O08537 ENSMUS 13983 0.17971 1000.00 1 0 0 0 0 0 0 70.0130 0 0 323.485
receptor 99.1 OUSE G0000002 2495 8764 06
beta 1055
G2 and S Gtse1 CS IPI002682 GTSE1_ Q8R080 ENSMUS 29870 0.17971 0.00 1 0 146.470 0 0 179.953 0 0 0 0 0
phase- 47.4 MOUSE G0000002 2495 5809 6327
expressed 2385
protein 1
Ubiquitin Uchl1 ENZ IPI003139 UCHL1_ Q9R0P9 ENSMUS 22223 0.17971 0.00 6 0 0 55.4978 0 385.927 0 0 0 0 0
carboxyl- 62.3 MOUSE G0000002 2495 7489 4873
terminal 9223
hydrolase
isozyme L1
CREB/ATF Crebzf TF IPI003150 ZHANG_ Q91ZR3 ENSMUS 233490 0.17971 0.00 1 298.681 0 263.519 0 0 0 0 0 0 0
bZIP 49.2 MOUSE G0000005 2495 0347 3079
transcriptio 1451
n factor
Purine Pnp ENZ IPI003154 PNPH_M P23492 18950 0.17971 0.00 4 120.514 118.159 0 0 0 0 0 0 0 0
nucleoside 52.5 OUSE 2495 2328 2912
phosphoryl
ase
40S Rps18 RIB IPI003175 RS18_M Q561N5 ENSMUS 20084 0.17971 0.00 4 0 88.6306 0 437.500 0 0 0 0 0 0
ribosomal 90.5 OUSE G0000000 2495 8084 2597
protein S18 8668
Glycogen Pygl ENZ IPI003195 PYGL_M Q9ET01 ENSMUS 110095 0.17971 0.00 12 705.532 318.482 0 0 0 0 0 0 0 0
phosphoryl 25.4 OUSE G0000002 2495 1704 7265
ase, liver 1069
form
Glutathione Gpx1 ENZ IPI003196 GPX1_M P11352 ENSMUS 14775 0.17971 1000.00 2 0 0 0 0 0 0 134.416 0 79.0132 0
peroxidase 52.2 OUSE G0000006 2495 9501 8996
1 3856
Usher Ushbp1 UK IPI003213 USBP1_ Q8R370 ENSMUS 234395 0.17971 1000.00 1 0 0 0 0 0 0 108.592 139.088 0 0
syndrome 62.2 MOUSE G0000003 2495 4551 4302
type-1C 4911
protein-
binding
protein 1
Glutathione Gsta4 ENZ IPI003239 GSTA4_ P24472 ENSMUS 14860 0.17971 0.00 2 0 378.734 0 0 146.930 0 0 0 0 0
S- 11.3 MOUSE G0000003 2495 8932 709
transferase 2348
A4
IQ motif Iqsec3 MOD IPI003301 IQEC3_M Q3TES0 ENSMUS 243621 0.17971 0.00 1 224.880 0 87.9879 0 0 0 0 0 0 0

- 36 -
and SEC7 67.4 OUSE G0000004 2495 7963 3689
domain- 0797
containing
protein 3
Zinc finger Znf445 TF IPI003369 ZN445_M Q8CBF5 ENSMUS 235682 0.17971 1000.00 1 0 0 0 0 0 0 72.8212 0 0 85.2471
protein 445 23.2 OUSE G0000004 2495 4849 3087
7036
Pre- Prpf40a TF IPI003388 PR40A_ Q9R1C7 ENSMUS 56194 0.17971 0.00 1 0 168.136 167.227 0 0 0 0 0 0 0
mRNA- 87.3 MOUSE G0000006 2495 9587 2218
processing 1136
factor 40
homolog A
Splicing Scaf1 TF IPI003444 SFR19_M Q5U4C3 ENSMUS 233208 0.17971 1000.00 3 0 0 0 0 0 47.1731 0 0 211.966 0
factor, 30.2 OUSE G0000003 2495 7933 5685
arginine/ser 8406
ine-rich 19
Keratin, Krt76 CS IPI003468 K22O_M Q3UV17 ENSMUS 77055 0.17971 1000.00 3 0 0 0 0 0 0 40.4686 0 105.239 0
type II 34.1 OUSE G0000007 2495 7647 8805
cytoskeletal 5402
2 oral
Protein Card6 MOD IPI003510 E9PWH2 Q8BWE0 ENSMUS 239319 0.17971 1000.00 1 0 0 0 0 0 175.493 0 0 0 168.671
Card6 41.1 _MOUSE G0000004 2495 5165 2928
(Caspase 1849
recruitment
domain
family,
member 6 )
Leucine- Lrrc36 UK IPI003542 LRC36_ Q3V0M2 ENSMUS 270091 0.17971 1000.00 1 0 0 0 0 0 564.602 340.221 0 0 0
rich repeat- 88.8 MOUSE G0000005 2495 514 9002
containing 4320
protein 36
40S Rps26 RIB IPI003774 RS26_M P62855 ENSMUS 27370 0.17971 0.00 2 0 0 35.5071 110.383 0 0 0 0 0 0
ribosomal 41.3 OUSE G0000002 2495 1548 8444
protein S26 5362|ENS
MUSG00
00005977
5
Elongator Ikbkap TF IPI003807 ELP1_M Q7TT37 ENSMUS 230233 0.17971 1000.00 1 0 0 0 0 0 0 0 77.6623 56.8570 0
complex 80.7 OUSE G0000002 2495 2834 0063
protein 1 8431
Cytospin-B Specc1 CS IPI003815 CYTSB_ Q5SXY1 ENSMUS 0.17971 1000.00 5 0 0 0 0 0 2558.28 3870.78 0 0 0
63.4 MOUSE G0000004 2495 2338 3566
2331
Protein Gm152 UK IPI003819 Q3V0P3_ Q3V0P3 ENSMUS 385263 0.17971 0.00 1 497.104 0 0 0 159.093 0 0 0 0 0
Gm1527 7 89.3 MOUSE G0000007 2495 2229 4149
4655
40S Rps24 RIB IPI004029 RS24_M P62849 ENSMUS 20088 0.17971 0.00 1 27.2548 0 0 42.6474 0 0 0 0 0 0
ribosomal 81.2 OUSE G0000002 2495 9916 6862
protein S24 5290
VPS10 Sorcs2 TM IPI004031 SORC2_ Q8BI74 ENSMUS 81840 0.17971 0.00 1 0 258.509 0 158.957 0 0 0 0 0 0
domain- 06.1 MOUSE G0000002 2495 7641 4163
containing 9093
receptor
SorCS2
Protein Sfi1 CS IPI004046 SFI1_MO Q3UZY0 ENSMUS 78887 0.17971 1000.00 2 0 0 0 0 0 85.5605 0 0 0 132.172
SFI1 36.8 USE G0000002 2495 4331 388

- 37 -
homolog 3764
Zinc finger Zfp366 TF IPI004210 Q6NS86_ Q6NS86 ENSMUS 238803 0.17971 0.00 3 276.455 0 240.545 0 0 0 0 0 0 0
protein 366 13.1 MOUSE G0000005 2495 317 7617
0919
Putative Gm196 UK IPI004575 Q8BIA5_ Q8BIA5 0.17971 0.00 1 370.828 0 147.507 0 0 0 0 0 0 0
uncharacter 65 49.1 MOUSE 2495 9141 857
ized protein
Putative Klhl24 UK IPI004594 Q8C6L1_ Q8C6L1 0.17971 0.00 2 0 0 105.891 211.511 0 0 0 0 0 0
uncharacter 54.5 MOUSE 2495 1353 2934
ized protein
Klhl24
RNA- Rbm41 TF IPI004600 RBM41_ Q8JZV4 ENSMUS 237073 0.17971 0.00 1 253.034 461.861 0 0 0 0 0 0 0 0
binding 72.2 MOUSE G0000003 2495 9999 0186
protein 41 1433
Putative 170002 UK IPI004600 Q3ULV3_ Q3ULV3 0.17971 1000.00 1 0 0 0 0 0 81.7793 0 0 0 289.416
uncharacter 2K14Ri 88.4 MOUSE 2495 0716 9337
ized protein k
1700022K1
4Rik
Protein Ankhd1 SCA IPI004624 E9Q1M6_ Q8C103 ENSMUS 0.17971 1000.00 1 0 0 0 0 0 0 89.9321 0 0 292.363
Ankhd1 76.5 MOUSE G0000002 2495 5161 1435
(Ankyrin 4483
repeat and
KH
domain-
containing
protein 1)
Delphilin Grid2ip SCA IPI004636 GRD2I_ Q0QWG9 ENSMUS 170935 0.17971 0.00 2 0 232.501 330.332 0 0 0 0 0 0 0
77.2 MOUSE G0000001 2495 2562 6667
0825
Mitogen- Map3k1 ENZ IPI004656 M3K15_ A2AQW0 ENSMUS 270672 0.17971 1000.00 2 0 0 0 0 0 0 207.166 0 742.855 0
activated 5 57.7 MOUSE G0000003 2495 7232 5737
protein 1303
kinase
kinase
kinase 15
Protein Ccdc88 SIG IPI004683 DAPLE_ Q80XQ1 ENSMUS 68339 0.17971 0.00 4 144.864 365.217 0 0 0 0 0 0 0 0
Daple c 83.4 MOUSE G0000002 2495 12 642
1182
Threonine-- Tars ENZ IPI004686 SYTC_M Q9D0R2 ENSMUS 110960 0.17971 0.00 2 268.433 0 152.438 0 0 0 0 0 0 0
tRNA 88.4 OUSE G0000002 2495 3265 229
ligase, 2241
cytoplasmic
Reticulon-4 Rtn4 DEV IPI004701 Q8BH78_ Q8BH78 ENSMUS 68585 0.17971 0.00 3 118.084 0 142.304 0 0 0 0 0 0 0
67.3 MOUSE G0000002 2495 2164 5663
0458
EP300- Eid1 TF IPI004743 EID1_MO Q9CZL9 ENSMUS 58521 0.17971 0.00 1 68.9232 0 95.9615 0 0 0 0 0 0 0
interacting 29.1 USE G0000009 2495 7032 9656
inhibitor of 1337
differentiati
on 1
Partitioning Pard3b CC IPI005154 PAR3L_ Q5SV54 ENSMUS 72823 0.17971 1000.00 2 0 0 0 0 0 0 341.489 0 75.9223 0
defective 3 65.3 MOUSE G0000005 2495 382 4114
homolog B 2062
Mediator of Med12l TF IPI005511 MD12L_ Q8BQM9 ENSMUS 329650 0.17971 0.00 1 0 0 126.410 910.676 0 0 0 0 0 0
RNA 59.4 MOUSE G0000005 2495 9281 0391

- 38 -
polymerase 6476
II
transcriptio
n subunit
12-like
protein
Desmoplaki Dsp CS IPI005534 DESP_M E9Q557 ENSMUS 109620 0.17971 0.00 2 0 45.4806 44.7339 0 0 0 0 0 0 0
n 19.3 OUSE G0000005 2495 4374 4401
4889
6- Pfkl ENZ IPI005548 K6PL_M Q8CD98 ENSMUS 18641 0.17971 0.00 3 105.691 117.395 0 0 0 0 0 0 0 0
phosphofru 62.3 OUSE G0000002 2495 3067 1866
ctokinase, 0277
liver type
Dual Duox2 ENZ IPI006060 A2AQ99_ A2AQ99 ENSMUS 214593 0.17971 1000.00 3 0 0 0 0 0 0 229.675 0 0 582.328
oxidase 2 08.2 MOUSE G0000006 2495 3818 8826
8452
Dipeptidyl Dpp9 ENZ IPI006067 DPP9_M Q8BVG4 ENSMUS 224897 0.17971 1000.00 1 0 0 0 0 0 0 0 58.2218 105.425 0
peptidase 9 31.1 OUSE G0000000 2495 7347 0577
1229
Sarcalumen Srl TP IPI006216 SRCA_M Q7TQ48 ENSMUS 106393 0.17971 1000.00 6 0 0 0 0 0 155.808 0 0 0 293.662
in 17.1 OUSE G0000002 2495 1746 6628
2519
Potassium Kcnq3 CNL IPI006245 KCNQ3_ Q8K3F6 ENSMUS 110862 0.17971 1000.00 3 0 0 0 0 0 279.108 259.884 0 0 0
voltage- 04.5 MOUSE G0000005 2495 9166 2356
gated 6258
channel
subfamily
KQT
member 3
Potassium Kcnh8 CNL IPI006260 KCNH8_ P59111 211468 0.17971 1000.00 1 0 0 0 0 0 0 0 162.293 165.542 0
voltage- 12.3 MOUSE 2495 582 2208
gated
channel
subfamily
H member
8
Retinal Aldh1a ENZ IPI006266 AL1A1_ P24549 ENSMUS 11668 0.17971 1000.00 3 0 0 0 0 0 88.2232 84.0073 0 0 0
dehydrogen 1 62.3 MOUSE G0000005 2495 961 4411
ase 1 3279
Nuclease- Ybx1 TF IPI006479 YBOX1_ A2BGG7 ENSMUS 22608 0.17971 0.00 1 26.8369 0 19.6237 0 0 0 0 0 0 0
sensitive 81.3 MOUSE G0000002 2495 4457 7136
element- 8639
binding
protein 1
Bardet- Bbs12 CHA IPI006484 BBS12_M A2AGT2 ENSMUS 241950 0.17971 0.00 1 0 136.889 0 106.044 0 0 0 0 0 0
Biedl 75.2 OUSE G0000005 2495 452 6115
syndrome 1444
12 protein
homolog
Girdin Ccdc88 CS IPI006486 GRDN_M Q5SNZ0 ENSMUS 108686 0.17971 1000.00 1 0 0 0 0 0 34.8659 0 0 0 318.864
a 05.2 OUSE G0000003 2495 3245 3836
2740
Nef- Nap1 ENZ IPI006495 NAP1_M Q562D6 ENSMUS 74753 0.17971 1000.00 1 0 0 0 0 0 141.523 0 0 0 176.586
associated 53.3 OUSE G0000002 2495 2066 5942
protein 1 8331
Regulator Fam82b CS IPI006495 RMD1_M A2AGJ2 ENSMUS 66302 0.17971 1000.00 1 0 0 0 0 0 95.9370 62.2099 0 0 0

- 39 -
of 89.1 OUSE G0000002 2495 7106 3721
microtubule 8229
dynamics
protein 1
Phosphatid Pik3cd ENZ IPI006496 PK3CD_ O35904 ENSMUS 18707 0.17971 0.00 1 255.937 181.085 0 0 0 0 0 0 0 0
ylinositol 28.1 MOUSE G0000003 2495 9416 6313
4,5- 9936
bisphosphat
e 3-kinase
catalytic
subunit
delta
isoform
DEP Deptor SIG IPI006522 DPTOR_ Q570Y9 ENSMUS 97998 0.17971 0.00 2 329.641 341.590 0 0 0 0 0 0 0 0
domain- 39.2 MOUSE G0000002 2495 5855 9022
containing 2419
mTOR-
interacting
protein
Macrophag Csf1r ENZ IPI006535 CSF1R_ Q3TBH6 ENSMUS 12978 0.17971 1000.00 1 0 0 0 0 0 0 10.7546 0 38.0936 0
e colony- 48.3 MOUSE G0000002 2495 5127 5337
stimulating 4621
factor 1
receptor
Protein UK IPI006693 F1M8Y5 ENSRNO 0.17971 1000.00 3 0 0 0 0 0 0 35.2124 0 34.6246 0
RGD15630 90.4 G0000003 2495 6588 8679
34 2392
Cone Pde6c ENZ IPI007423 PDE6C_ Q91ZQ1 ENSMUS 110855 0.17971 1000.00 1 0 0 0 0 0 102.046 100.025 0 0 0
cGMP- 18.1 MOUSE G0000002 2495 6576 2814
specific 4992
3',5'-cyclic
phosphodie
sterase
subunit
alpha'
Uveal Uaca MOD IPI007423 UACA_M Q8CGB3 ENSMUS 72565 0.17971 0.00 4 0 0 140.293 592.047 0 0 0 0 0 0
autoantigen 50.1 OUSE G0000003 2495 7798 8956
with coiled- 4485
coil
domains
and ankyrin
repeats
GAS2-like Gas2l3 UK IPI007614 GA2L3_ Q3TPC3 ENSMUS 237436 0.17971 0.00 1 270.459 0 417.441 0 0 0 0 0 0 0
protein 3 64.1 MOUSE G0000007 2495 058 4741
4802
Ubiquitin- Uspl1 ENZ IPI007620 USPL1_ Q3ULM6 ENSMUS 231915 0.17971 0.00 2 0 0 42.9795 0 94.9014 0 0 0 0 0
specific 08.3 MOUSE G0000004 2495 8851 3448
peptidase- 1264
like protein
1
Anti- Gm149 IGG IPI007626 Q9JL76_ Q9JL76 0.17971 0.00 3 208.154 415.731 0 0 0 0 0 0 0 0
myosin 9 25.1 MOUSE 2495 0318 4763
immunoglo
bulin light
chain
variable
region

- 40 -
Metastasis- Mta1 TF IPI007760 MTA1_M F8WHY8 ENSMUS 0.17971 0.00 1 123.434 0 72.0300 0 0 0 0 0 0 0
associated 55.1 OUSE G0000002 2495 9921 9099
protein 1144
MTA1
PR domain Prdm2 TF IPI007985 B9EKQ3_ Q80VF3 110593 0.17971 0.00 3 373.206 0 107.455 0 0 0 0 0 0 0
zinc finger 19.6 MOUSE 2495 8257 2995
protein 2
Copper- Atp7b TP IPI008285 ATP7B_ B1AQ57 ENSMUS 11979 0.17971 0.00 2 20.3176 0 369.286 0 0 0 0 0 0 0
transporting 26.2 MOUSE G0000000 2495 0594 7915
ATPase 2 6567
Protein Fam187 TM IPI008447 F187B_M Q0VAY3 ENSMUS 76415 0.17971 1000.00 1 0 0 0 0 0 0 0 186.934 250.089 0
FAM187B b 55.1 OUSE G0000004 2495 1671 5831
6826
Lysine- Kdm5a ENZ IPI008490 KDM5A_ Q3UXZ9 ENSMUS 214899 0.17971 1000.00 1 0 0 0 0 0 52.2653 0 0 142.990 0
specific 89.1 MOUSE G0000003 2495 7253 1124
demethylas 0180
e 5A
Melanoma Mia3 TP IPI008501 MIA3_M Q8BI84 338366 0.17971 0.00 1 410.029 302.894 0 0 0 0 0 0 0 0
inhibitory 56.1 OUSE 2495 6705 4516
activity
protein 3
60S Rpl19 RIB IPI008537 RL19_M P84099 ENSMUS 19921 0.17971 0.00 1 0 25.9610 0 89.1905 0 0 0 0 0 0
ribosomal 88.2 OUSE G0000001 2495 0865 266
protein 7404
L19-like,
partial
Alpha27- Gm324 UK IPI008550 E9Q2P2_ A6NAW0 ENSMUS 0.17971 1000.00 2 0 0 0 0 0 251.990 768.620 0 0 0
takusan 8 18.2 MOUSE G0000009 2495 2127 4097
1275
Nuclear Nup210 TP IPI008562 PO210_M Q8C5C6 ENSMUS 54563 0.17971 0.00 1 126.136 0 83.3620 0 0 0 0 0 0 0
pore 20.1 OUSE G0000003 2495 2091 5275
membrane 0091
glycoprotei
n 210
Dynactin Dctn1 TP IPI008580 DCTN1_ D3YX34 ENSMUS 13191 0.17971 1000.00 1 0 0 0 0 0 0 104.292 0 0 429.681
subunit 1 04.1 MOUSE G0000003 2495 3753 6547
1865
Apoptosis Bcl2l14 MOD IPI008580 B2L14_M D3YZF2 ENSMUS 66813 0.17971 1000.00 1 0 0 0 0 0 0 0 59.5852 79.9228 0
facilitator 45.1 OUSE G0000003 2495 9714 8067
Bcl-2-like 0200
protein 14
Axin-1 Axin1 DEV IPI008758 AXIN1_ O35625 12005 0.17971 0.00 1 70.4092 70.6613 0 0 0 0 0 0 0 0
49.1 MOUSE 2495 5952 6642
Fatty acid- Fabp5 TP IPI008765 FABP5_ Q3TLH6 ENSMUS 16592 0.17971 0.00 1 23.7688 0 0 34.6835 0 0 0 0 0 0
binding 63.1 MOUSE G0000002 2495 1674 7679
protein, 7533
epidermal
Janus Jakmip1 TP IPI008806 JKIP1_M D3Z4U5 ENSMUS 76071 0.17971 1000.00 1 0 0 0 0 0 0 66.9920 0 0 112.387
kinase and 30.1 OUSE G0000006 2495 3029 9742
microtubule 3646
-interacting
protein 1
Cdc42 Cdc42e CS IPI008806 BORG3_ D3Z5F0 ENSMUS 58804 0.17971 0.00 1 0 0 186.699 0 144.924 0 0 0 0 0
effector p5 31.1 MOUSE G0000006 2495 6628 2078
protein 5 3838
Nuclear Tpr TP IPI008806 Q7M739_ E9PZZ3 ENSMUS 0.17971 1000.00 4 0 0 0 0 0 1374.20 32.0420 0 0 0

- 41 -
pore 44.3 MOUSE G0000000 2495 9002 6283
complex- 6005
associated
intranuclear
coiled-coil
protein
TPR
Acetolactat Ilvbl ENZ IPI008812 ILVBL_ Q8BU33 ENSMUS 216136 0.17971 1000.00 1 0 0 0 0 0 582.264 0 758.925 0 0
e synthase- 09.1 MOUSE G0000003 2495 6708 0126
like protein 2763
Adenylyl Cap2 MOD IPI008823 CAP2_M D3YTR7 ENSMUS 67252 0.17971 0.00 1 28.4667 24.0240 0 0 0 0 0 0 0 0
cyclase- 16.1 OUSE G0000002 2495 0468 71
associated 1373
protein 2
Sodium Scn5a CNL IPI008946 SCN5A_ Q9JJV9 ENSMUS 20271 0.17971 1000.00 1 0 0 0 0 0 0 89.3415 0 0 181.088
channel 90.3 MOUSE G0000003 2495 7375 9885
protein type 2511
5 subunit
alpha
Interferon Irf5 TF IPI008949 IRF5_MO E9Q5T2 ENSMUS 27056 0.17971 0.00 1 52.4345 0 65.3301 0 0 0 0 0 0 0
regulatory 93.2 USE G0000002 2495 8979 0626
factor 5 9771
Protein Slmo2 UK IPI008951 SLMO2_ B0QZU2 ENSMUS 66390 0.17971 1000.00 1 0 0 0 0 0 154.419 0 0 0 198.545
slowmo 91.1 MOUSE G0000001 2495 1896 3098
homolog 2 6257
Ubiquitin Ube4b MOD IPI008952 UBE4B_ B2KFK1 ENSMUS 63958 0.17971 0.00 1 22.8255 0 23.5709 0 0 0 0 0 0 0
conjugation 39.2 MOUSE G0000002 2495 5961 4831
factor E4 B 8960
Unconventi Myo5a TP IPI009280 MYO5A_ D3YZ62 ENSMUS 17918 0.17971 0.00 3 0 0 470.110 37.1682 0 0 0 0 0 0
onal 07.1 MOUSE G0000003 2495 3013 9971
myosin-Va 4593
DnaJ Dnajb1 CHA IPI009284 DJB12_M Q9QYI4 ENSMUS 56709 0.17971 1000.00 1 0 0 0 0 0 0 47.6993 0 0 152.556
homolog 2 98.1 OUSE G0000002 2495 4387 7726
subfamily 0109
B member
12
Hypoxia Hyou1 CHA IPI009700 HYOU1_ E0CYZ2 ENSMUS 12282 0.17971 0.00 2 99.4808 0 0 199.734 0 0 0 0 0 0
up- 05.1 MOUSE G0000003 2495 1127 0383
regulated 2115
protein 1
Eyes absent Eya1 ENZ IPI009860 EYA1_M Q8C9D0 ENSMUS 0.17971 1000.00 1 0 0 0 0 0 0 0 0 24.0632 62.8928
homolog 1 22.1 OUSE G0000002 2495 5088 3537
5932
Protein Gm145 UK IPI009881 E9Q0C6_ E9Q0C6 ENSMUS 0.17971 0.00 1 114.047 126.464 0 0 0 0 0 0 0 0
Gm14569 69 20.1 MOUSE G0000009 2495 0325 5291
1556
Proteasome Psma8 ENZ IPI009907 PSA7L_ F6ZKL1 ENSMUS 73677 0.17971 0.00 1 0 0 46.5592 58.8154 0 0 0 0 0 0
subunit 07.2 MOUSE G0000003 2495 2061 638
alpha type- 6743
7-like
Proprotein Pcsk7 ENZ IPI010081 PCSK7_ E9PZ65 ENSMUS 18554 0.17971 0.00 1 156.402 124.058 0 0 0 0 0 0 0 0
convertase 02.1 MOUSE G0000003 2495 4642 9448
subtilisin/k 5382
exin type 7
Centromere Cenpe CC IPI010086 CENPE_ E9QKK1 ENSMUS 229841 0.17971 0.00 4 216.939 0 382.911 0 0 0 0 0 0 0
-associated 82.1 MOUSE G0000004 2495 2447 3463

- 42 -
protein E 5328
Histone- Mll3 TF IPI010267 MLL3_M Q3TU00 ENSMUS 0.17971 1000.00 2 0 0 0 0 0 171.163 145.533 0 0 0
lysine N- 44.1 OUSE G0000003 2495 9328 1375
methyltrans 8056
ferase
MLL3
Receptor Reep5 TM IPI003154 REEP5_ Q60870 0.18122 3.41 2 0 0 73.6667 0 0 71.9430 31.2931 68.5046 79.6425 0
expression- 63.4 MOUSE 0536 8326 4676 9273 3658 0955
enhancing
protein 5
Nucleoside Nme1 ENZ IPI006495 NDKA_M Q5NC80 ENSMUS 18102 0.18122 0.30 5 380.193 421.917 0 674.428 367.578 0 0 0 558.565 0
diphosphate 86.1 OUSE G0000003 0536 5819 8744 7567 8631 2759
kinase A 7601
Plectin Plec CS IPI009748 PLEC_M E9Q3W4 ENSMUS 18810 0.18122 3.19 14 0 0 815.612 0 0 438.846 716.974 405.881 0 1042.05
53.1 OUSE G0000002 0536 552 3969 9884 0281 3212
2565
Serotransfe Tf TP IPI009879 TRFE_M E9Q035/F ENSMUS 22041 0.18201 0.77 55 5724.95 6157.55 3136.96 2815.85 8872.69 5467.99 2177.88 4147.05 3403.58 5315.53
rrin 51.1/IPI00 OUSE 7CJN9/Q9 G0000009 2168 6586 6892 8263 4058 7048 6189 317 9262 326 3366
991056.1/ 21I1 0639|ENS
IPI001397 MUSG00
88.2 00003255
4
Adenylate Ak2 ENZ mitocho IPI008815 KAD2_M F7BP55/Q ENSMUS 11637 0.18502 0.71 9 468.918 242.117 218.623 295.927 120.182 123.241 84.1226 292.973 369.883 83.9980
kinase 2, ndria 89.1/IPI00 OUSE 9WTP6 G0000002 3958 7104 0629 2305 872 3391 4089 5725 6616 0137 7875
mitochondr 269076.3 8792
ial
Methylglut Auh ENZ mitocho IPI008807 AUHM_ F6R307/Q ENSMUS 11992 0.19433 3.63 4 12.8330 0 0 0 0 8.79540 0 84.4016 0 0
aconyl- ndria 12.1/IPI00 MOUSE 9JLZ3 G0000002 7694 798 4467 0163
CoA 357511.1 1460
hydratase,
mitochondr
ial
Testis- Tex2 TM IPI006487 TEX2_M B1ATR4/ ENSMUS 21763 0.19656 0.26 3 0 64.8249 251.215 0 0 0 0 46.9754 0 33.7145
expressed 97.1/IPI00 OUSE Q6ZPJ0 G0000004 5112 0238 2062 2211 6455
sequence 2 420516.3 0548
protein
Transcripti Trerf1 TF IPI004679 TREF1_ Q8BXJ2 ENSMUS 224829 0.20178 0.40 5 719.092 745.880 0 0 0 0 0 0 256.337 329.780
onal- 47.2/IPI00 MOUSE G0000006 4122 5617 3993 4807 2475
regulating 420739.2/ 4043
factor 1 IPI006493
65.1
Tropomyos Tpm1 CS muscle IPI008316 TPM1_M Q6AZ25/ ENSMUS 22003 0.20346 1.32 92 5632.79 6089.39 6015.30 3761.10 2223.74 7119.38 2671.78 6516.87 3669.91 11306.5
in alpha-1 26.1/IPI00 OUSE Q8BP43/ G0000003 2943 0184 3671 43 1485 2968 9231 1547 0937 9492 1123
chain 403987.2/ B7ZNL3/ 2366
IPI008306 E9Q450/E
04.1/IPI00 9Q452/F8
830884.1/ WID5/P5
IPI008304 8771
27.1/IPI00
830701.1/
IPI002278
35.1
Aspartate Got2 ENZ mitocho IPI001173 AATM_ P05202 ENSMUS 14719 0.20450 4.35 13 44.7333 0 158.338 0 256.506 471.520 223.908 201.416 0 1101.37
aminotransf ndria 12.1 MOUSE G0000003 0533 4183 0045 5519 8391 0346 766 5171
erase, 1672
mitochondr
ial

- 43 -
Guanine Gnao1 SIG IPI001155 GNAO_M P18872 ENSMUS 14681 0.20450 1.97 2 0 190.024 0 0 358.524 233.796 117.163 206.835 311.805 212.101
nucleotide- 46.4 OUSE G0000003 0533 3889 4348 9938 7466 2018 3389 4965
binding 1748
protein
G(o)
subunit
alpha
Telomerase Tep1 CC IPI001256 TEP1_M P97499 ENSMUS 21745 0.20450 0.54 2 206.973 182.014 184.890 234.323 0 123.101 0 187.849 0 127.410
protein 67.1 OUSE G0000000 0533 7505 9885 1867 4155 3668 9925 1051
component 6281
1
Lipoxygena Loxhd1 CS IPI007853 E9PVB2_ E9PVB2 ENSMUS 0.20450 0.55 2 0 289.833 258.761 430.427 185.212 228.597 0 180.002 237.420 0
se 27.1 MOUSE G0000003 0533 4404 4768 2976 7683 5387 8312 6657
homology 2818
domain-
containing
protein 1
Protein Son TF IPI008757 SON_MO Q8BM30/ ENSMUS 20658 0.20558 0.80 3 188.280 252.888 152.918 0 170.198 88.8230 61.6472 307.198 0 0
SON 79.2/IPI00 USE Q9QX47 G0000002 2779 8733 9101 3372 4109 3735 3909 3338
310168.7 2961
60S Rpl7a RIB IPI004613 RL7A_M Q8CDE3/ ENSMUS 27176 0.20705 0.41 8 0 180.407 145.703 667.663 0 19.0071 0 0 153.263 236.080
ribosomal 56.1/IPI00 OUSE D3YU93 G0000006 2413 6203 8794 0894 9144 2893 9511
protein L7a 265107.4 8579|ENS
MUSG00
00006645
2|ENSMU
SG000000
62647
Microtubul Map4 CS IPI004734 MAP4_M F7CK47/P ENSMUS 17758 0.20851 0.45 8 20.0981 88.3379 196.405 0 955.668 0 0 101.803 26.8086 297.977
e- 77.2/IPI00 OUSE 27546 G0000003 7244 7274 7864 8668 6047 5093 1767 8689
associated 408119.6/ 2479
protein 4 IPI004067
41.6
Neurobeach Nbea SCA IPI003208 NBEA_M Q9EPN1 ENSMUS 26422 0.20869 2.14 5 32.2760 502.316 371.627 0 0 402.655 186.632 364.881 396.917 586.573
in 31.3 OUSE G0000002 0443 1942 2257 7927 8684 5079 6469 57 2866
7799
Fanconi Fancm ENZ IPI009884 FANCM_ E9Q3W0/ ENSMUS 104806 0.20890 0.62 3 155.801 54.9230 0 0 0 0 0 0 65.8254 0
anemia 23.2/IPI00 MOUSE Q8BGE5 G0000005 3994 4301 3894 7823
group M 471330.3 5884
protein
homolog
Epoxide Ephx2 ENZ IPI004076 HYES_M P34914 ENSMUS 13850 0.21063 0.77 6 135.166 0 0 0 0 0 39.8524 115.477 156.115 0
hydrolase 2 06.1/IPI00 OUSE G0000002 3095 5865 7673 7433 987
321617.1 2040
Formin-like Fmnl1 CS IPI001314 FMNL_M Q9JL26 ENSMUS 57778 0.21340 0.75 4 322.894 0 0 0 0 709.965 226.899 8.16732 21.2056 0
protein 1 41.5/IPI00 OUSE G0000005 568 619 2048 4549 6768 4626
123377.1 5805
Zinc finger Znf287 TF IPI006536 ZN287_M Q3UY44/ ENSMUS 170740 0.21378 0.74 5 0 0 0 0 587.813 0 268.257 670.919 367.821 0
protein 287 98.2/IPI00 OUSE Q5SVS9 G0000000 0567 6341 9943 9804 14
788365.2 5267
Isoleucine-- Iars2 ENZ mitocho IPI008301 SYIM_M E9PWN2/ ENSMUS 381314 0.21518 0.58 5 101.697 72.7454 116.077 0 0 57.0403 0 42.6571 70.2139 0
tRNA ndria 73.1/IPI00 OUSE Q8BIJ6 G0000002 5334 4001 3362 6778 6399 2618 746
ligase, 453499.3 6618
mitochondr
ial
Succinyl- Oxct1 ENZ mitocho IPI008581 SCOT1_ Q3UJQ9/ ENSMUS 67041 0.21606 1.03 12 583.735 511.570 471.439 589.120 0 462.930 399.129 718.740 855.702 333.886

- 44 -
CoA:3- ndria 56.1/IPI00 MOUSE Q9D0K2 G0000002 2484 3657 9972 4591 1657 6947 3697 9725 7406 096
ketoacid- 132653.1 2186
coenzyme
A
transferase
1,
mitochondr
ial
Cytochrom Cox7a2 ENZ mitocho IPI001143 CX7A2_ P48771 ENSMUS 12866 0.22222 0.70 2 548.359 596.106 565.536 547.420 329.583 305.074 108.618 515.019 625.129 261.137
e c oxidase ndria 77.1 MOUSE G0000003 2222 5802 1224 2639 2437 113 9178 763 9483 8439 5599
subunit 2330
7A2,
mitochondr
ial
ADP/ATP Slc25a4 TP mitocho IPI001155 ADT1_M P48962 ENSMUS 11739 0.22222 1.61 9 1140.82 1325.26 1911.58 1135.21 901.739 2186.05 1089.03 1738.24 1505.72 3790.05
translocase ndria 64.5 OUSE G0000003 2222 2259 4232 3405 5661 0388 8727 5041 403 5781 2706
1 1633
Cytochrom Mtco2 TP mitocho IPI001311 COX2_M P00405 ENSMUS 17709 0.22222 0.65 2 769.417 1119.10 1290.85 1181.30 327.613 498.377 282.659 975.542 833.701 452.521
e c oxidase ndria 76.1 OUSE G0000006 2222 0552 3626 1877 0239 2878 2685 6829 9316 9896 6129
subunit 2 4354
Cytochrom Cox6c TP mitocho IPI001317 COX6C_ Q9CPQ1 ENSMUS 12864 0.22222 0.70 6 1476.26 1770.63 1235.72 1538.27 461.553 858.549 484.521 1269.46 1176.18 750.550
e c oxidase ndria 71.3 MOUSE G0000001 2222 4583 3682 0922 0576 1518 8972 605 5587 5036 3733
subunit 6C 4313
Trifunction Hadha ENZ mitocho IPI002230 ECHA_M Q8BMS1 ENSMUS 97212 0.22222 0.75 16 5954.89 7304.03 6411.30 5347.43 2676.67 3527.15 2299.21 5539.26 5883.98 3457.73
al enzyme ndria 92.5 OUSE G0000002 2222 3046 4869 727 0791 3871 8637 224 5974 0649 0464
subunit 5745
alpha,
mitochondr
ial
Cytochrom Cyb5b TP mitocho IPI003157 CYB5B_ Q9CQX2 ENSMUS 66427 0.22222 0.70 3 189.010 179.002 107.948 59.6463 126.935 70.5777 37.1703 79.3504 100.852 175.139
e b5 type B ndria 94.1 MOUSE G0000003 2222 5971 4376 5256 1915 1977 9556 9293 0523 5206 9708
1924
Glycerol-3- Gpd2 ENZ mitocho IPI003311 GPDM_M Q64521 ENSMUS 14571 0.22222 0.56 16 1724.85 2363.23 1622.95 1462.40 506.559 833.061 334.269 1149.33 1794.48 186.643
phosphate ndria 82.4 OUSE G0000002 2222 0663 1948 2993 7665 7057 5171 2235 2878 7714 3037
dehydrogen 6827
ase,
mitochondr
ial
Pyruvate Pdha1 ENZ mitocho IPI003378 ODPA_M P35486 ENSMUS 18597 0.22222 0.66 11 1441.37 1389.28 1430.69 1285.26 0 578.037 384.414 900.639 1286.97 533.503
dehydrogen ndria 93.2 OUSE G0000003 2222 8464 982 3509 2717 7991 4009 6069 8344 9487
ase E1 1299
component
subunit
alpha,
somatic
form,
mitochondr
ial
ATP Atp5d TP mitocho IPI004537 ATPD_M Q9D3D9 ENSMUS 66043 0.22222 1.62 2 155.153 140.291 196.086 93.5780 0 167.275 144.679 156.179 142.067 338.297
synthase ndria 77.2 OUSE G0000000 2222 7377 6538 687 9348 0175 2878 2903 0922 3384
subunit 3072
delta,
mitochondr
ial
Myosin Myl6 TP muscle IPI004622 MYL6_M Q60605 ENSMUS 17904 0.22222 0.88 6 1341.57 1285.36 1382.04 1074.71 1326.26 1069.38 573.451 1191.27 1046.95 1788.57
light 32.3 OUSE G0000009 2222 9248 0771 3135 2733 3519 0243 8534 2307 7861 6873
polypeptide 0841

- 45 -
6
Collagen Col7a1 CS secreted IPI001346 CO7A1_ Q63870 ENSMUS 12836 0.22222 0.61 15 1026.56 822.521 1630.61 1349.82 856.199 1011.27 209.957 840.405 238.697 1146.04
alpha- 52.3 MOUSE G0000002 2222 5042 183 8736 8099 0541 9698 0316 7617 4366 5589
1(VII) 5650
chain
Serpin A11 Serpina INH secreted IPI002298 SPA11_M Q8CIE0 380780 0.22222 0.82 1 483.553 774.388 412.614 484.924 418.013 454.891 170.243 369.685 735.263 392.104
11 29.3 OUSE 2222 647 9785 8579 3185 168 9722 6189 4293 1991 1966
Gelsolin Gsn CS secreted IPI007599 GELS_M P13020 ENSMUS 227753 0.22222 0.69 8 347.332 381.566 258.378 95.6152 325.444 181.251 116.582 258.166 159.840 259.805
48.1 OUSE G0000002 2222 8254 6734 1927 4193 9863 9415 4283 2072 5984 9607
6879
Alpha- Actn4 CS IPI001188 ACTN4_ P57780 ENSMUS 60595 0.22222 1.00 13 357.531 375.744 327.571 229.053 290.080 259.527 225.272 199.071 205.930 684.844
actinin-4 99.1 MOUSE G0000005 2222 5283 3997 3104 0171 4954 5596 0708 2109 2212 7821
4808
Inactive Usp54 UK IPI002226 UBP54_ Q8BL06 ENSMUS 78787 0.22222 0.70 4 1089.98 892.781 566.060 624.858 426.273 516.211 300.541 593.942 720.450 383.706
ubiquitin 48.3 MOUSE G0000003 2222 4521 886 543 1601 1972 4886 9644 1261 501 8811
carboxyl- 4235
terminal
hydrolase
54
Centromere Cenpj CS IPI003568 CENPJ_ Q569L8 ENSMUS 219103 0.22222 0.55 4 230.653 221.052 363.235 175.944 192.655 201.152 79.6560 0 260.928 115.018
protein J 98.5 MOUSE G0000006 2222 1658 6509 4779 0302 9628 9467 2126 7159 7088
4128
WD repeat- Wdr19 CS IPI007543 WDR19_ Q3UGF1 ENSMUS 213081 0.22222 1.20 2 202.076 270.164 225.523 279.581 148.445 325.876 115.418 273.156 311.480 326.815
containing 32.1 MOUSE G0000003 2222 6029 2854 2485 971 954 8293 2578 1201 0715 4779
protein 19 7890
Dystonin Dst CS muscle IPI008746 DYST_M E9Q9X1/ ENSMUS 13518 0.22552 0.41 7 50.4006 79.9859 0 961.047 0 43.9592 0 0 0 253.740
75.2/IPI00 OUSE Q91ZU6 G0000002 9726 2796 6156 4291 526 4226
230689.3/ 6131
IPI002306
90.1
Ubiquitin- Ube2v2 CC IPI008948 UB2V2_ B2KF55/ ENSMUS 70620 0.22649 0.70 3 0 0 0 164.404 0 60.5566 0 153.843 131.400 0
conjugating 43.1/IPI00 MOUSE Q9D2M8 G0000002 2321 1389 7374 8841 5978
enzyme E2 670546.3 2674
variant 2
Glucose-6- Gpi ENZ IPI006695 G6PI_MO B7ZWL9/ ENSMUS 14751 0.22822 0.57 30 1627.76 3159.70 1729.82 0 1028.46 1015.70 1188.02 1476.69 1051.22 651.486
phosphate 56.2/IPI00 USE F6SAC3/ G0000004 8472 1738 5684 4482 3575 4656 5661 6166 1654 6954
isomerase 990532.1/ P06745 3192|ENS
IPI002286 MUSG00
33.7 00003642
7
Isocitrate Idh3a ENZ mitocho IPI006080 IDH3A_ Q9D6R2 ENSMUS 67834 0.23363 0.83 15 2164.57 2947.91 3374.34 3399.48 1224.88 2181.59 976.471 2781.34 3395.12 1486.16
dehydrogen ndria 78.1/IPI00 MOUSE G0000003 3567 2825 6371 2672 7151 2291 763 2143 828 2527 7792
ase [NAD] 459725.2 2279
subunit
alpha,
mitochondr
ial
Histone Hist1h1 TF IPI002301 H15_MO P43276 ENSMUS 56702 0.23586 0.37 5 419.599 380.736 0 479.640 973.567 0 178.399 0 0 645.487
H1.5 b 33.5 USE G0000005 131 1055 5373 2929 2229 9292 607
8773
Dihydropyr Crmp1 SIG IPI008751 DPYL1_ P97427 ENSMUS 12933 0.23586 0.42 3 295.675 348.372 312.810 0 405.372 0 0 205.228 0 362.222
imidinase- 17.1 MOUSE G0000002 131 2607 1136 9399 1144 3271 608
related 9121
protein 1
40S Rps16 RIB IPI009858 RS16_M P14131 ENSMUS 20055 0.23586 0.23 4 91.6304 37.8963 66.9795 295.392 0 0 0 19.0124 0 91.7660
ribosomal 89.1 OUSE G0000003 131 7172 0839 4815 4165 9679 1238

- 46 -
protein 7563
S16-like
Chymase Cma1 ENZ secreted IPI002304 CMA1_M P21844 17228 0.23931 0.24 2 58.4372 0 81.4890 0 183.705 0 0 78.1180 0 0
26.4 OUSE 6541 0096 3947 3222 7779
Tubulin Tuba4a CS IPI001173 TBA4A_ P68368 ENSMUS 22145 0.23931 3.18 6 508.131 0 0 0 0 302.088 0 526.735 0 784.767
alpha-4A 50.1 MOUSE G0000002 6541 2463 6844 973 2763
chain 6202
Heat shock Hspb8 CHA IPI001224 HSPB8_ Q9JK92 ENSMUS 80888 0.23931 0.23 1 0 164.879 136.071 41.5632 0 0 0 0 0 77.5028
protein 28.1 MOUSE G0000004 6541 4102 4347 646 5294
beta-8 1548
Ras-related Rab10 TP IPI001301 RAB10_ P61027 ENSMUS 19325 0.23931 2.74 2 0 0 190.605 0 0 0 79.3238 230.290 212.603 0
protein 18.1 MOUSE G0000002 6541 0682 0315 2597 4775
Rab-10 0671
Hypoxanthi Hprt1 ENZ IPI002848 HPRT_M P00493 ENSMUS 15452 0.23931 3.46 1 0 101.786 0 0 0 117.582 40.3209 194.051 0 0
ne-guanine 06.8 OUSE G0000002 6541 7847 0805 9887 174
phosphorib 5630
osyltransfer
ase
Histone- Mll2 ENZ IPI003812 MLL2_M Q6PDK2 ENSMUS 0.23931 0.08 8 148.982 961.231 1345.70 0 0 206.534 0 0 0 0
lysine N- 44.9 OUSE G0000004 6541 8603 3429 5718 8118
methyltrans 8154
ferase
MLL2
Putative 170010 UK IPI004055 Q8C6K5_ Q8C6K5 0.23931 3.45 1 0 0 150.567 0 0 183.145 124.194 0 211.983 0
uncharacter 9F18Ri 25.1 MOUSE 6541 7425 1437 8886 8955
ized protein k
1700109F1
8Rik
Putative 241001 TF IPI004074 Q8CEW7 Q8CEW7 71970 0.23931 4.27 3 45.7335 0 0 0 0 27.7801 0 72.4631 94.9482 0
uncharacter 8M08Ri 13.2 _MOUSE 6541 5463 7637 6997 8158
ized protein k
2410018M
08Rik
(SCAN
domain-
containing
protein 3)
Cortactin- Cttnbp2 UK IPI006729 B9EJA2_ B9EJA2 0.23931 0.16 3 0 601.262 479.508 0 109.428 0 0 0 189.911 0
binding 24.2 MOUSE 6541 4452 1104 3953 6458
protein 2
EGF-like Egfem1 UK IPI008861 EGFEM_ D3YYS1 ENSMUS 75740 0.23931 0.17 1 261.165 76.7629 0 0 184.362 0 0 0 87.5182 0
and EMI 65.1 MOUSE G0000006 6541 1312 497 1105 5073
domain- 3600
containing
protein 1
Protein Prrc2a TF IPI009876 PRC2A_ Q5DTJ4 ENSMUS 53761 0.23931 6.24 4 0 0 18.4682 0 0 14.0198 67.8419 33.4710 0 0
PRRC2A 45.1 MOUSE G0000002 6541 466 1602 786 9215
(Proline- 4393
rich and
coiled-coil-
containing
protein 2A)
Protein Gm221 UK IPI009889 D3YXL0_ D3YXL0 ENSMUS 0.23931 0.29 3 450.342 370.611 140.293 0 0 0 0 274.628 0 0
Gm221 66.1 MOUSE G0000001 6541 3608 725 7798 6378
(Coiled-coil 9767
domain-

- 47 -
containing
protein
C6orf97)
LETM1 Letmd1 SIG mitocho IPI001257 LTMD1_ Q924L1 ENSMUS 68614 0.23984 0.55 16 356.076 276.755 206.436 85.5140 0 87.1796 28.8234 189.316 274.755 50.1261
domain- ndria 71.3/IPI00 MOUSE G0000003 5209 0766 585 8238 6329 0853 0848 8118 1471 8133
containing 874965.1/ 7353
protein 1 IPI008755
66.1
Tubulin Tubb3 CS IPI001122 TBB3_M Q9CRT0/ ENSMUS 22152 0.24175 0.39 12 0 397.154 0 0 1465.52 208.541 0 0 0 514.638
beta-3 51.1/IPI00 OUSE Q9ERD7 G0000006 2158 8 7948 7083 4862
chain 989101.1 2380
Ubiquinone Coq9 ENZ mitocho IPI008856 COQ9_M F6SFF5/Q ENSMUS 67914 0.24187 1.00 11 424.260 371.888 398.496 306.001 0 367.271 256.358 539.472 508.149 204.529
biosynthesi ndria 46.1/IPI00 OUSE 8K1Z0 G0000003 1496 8347 1412 6355 2124 9814 4231 575 7765 0199
s protein 169862.1 1782
COQ9,
mitochondr
ial
Zinc finger Znf318 TF IPI004107 ZN318_M B8JJA0/G ENSMUS 57908 0.24664 0.66 5 0 0 939.269 0 0 682.928 344.898 0 0 820.149
protein 318 38.4/IPI00 OUSE 3X980 G0000001 5469 9544 9605 9984 2385
990494.1 5597
ATP Atp5c1 TP mitocho IPI007500 ATPG_M Q9Z1F5/ ENSMUS 11949 0.24784 1.43 14 501.442 415.699 191.268 0 189.654 489.528 279.013 321.483 0 760.030
synthase ndria 74.1/IPI00 OUSE A2AKV1 G0000002 5738 4599 2898 232 2268 081 128 5583 1302
subunit 775853.1 5781
gamma,
mitochondr
ial
NADH Ndufa8 TP mitocho IPI001209 NDUA8_ Q9DCJ5 ENSMUS 68375 0.24915 0.75 4 260.209 249.839 209.245 176.769 0 165.347 0 157.371 238.721 111.530
dehydrogen ndria 84.5 MOUSE G0000002 2639 5892 7349 8436 4495 5236 8982 8172 3442
ase 6895
[ubiquinone
] 1 alpha
subcomplex
subunit 8
Apoptosis- Aifm1 ENZ mitocho IPI007760 AIFM1_ B1AU25 ENSMUS 26926 0.24915 0.75 7 325.258 302.295 218.077 284.304 0 174.651 0 233.139 178.832 256.663
inducing ndria 47.1 MOUSE G0000003 2639 4293 7738 8964 0788 98 9706 8347 3777
factor 1, 6932
mitochondr
ial
Ig kappa IGG IPI008500 IGKC_M P01837 0.24915 0.61 4 371.979 443.558 0 235.665 352.636 97.9429 216.062 0 250.956 297.045
chain C 20.1 OUSE 2639 3655 8601 2575 1038 1763 3752 099 1754
region
Polyubiquit Ubc SIG IPI009230 UBC_MO Q5SX22 ENSMUS 22190 0.24915 0.72 4 581.247 431.047 415.486 0 550.961 327.089 259.180 412.586 431.533 0
in-C 13.1 USE G0000001 2639 0523 465 0339 6443 0941 037 3573 2046
9505|ENS
MUSG00
00000834
8
Basal cell Bcam CS IPI006246 BCAM_ Q8BGB4/ ENSMUS 57278 0.24967 1.68 6 80.6510 0 23.7214 0 23.0622 68.2462 0 0 46.8413 98.4622
adhesion 99.1/IPI00 MOUSE Q9R069 G0000000 6767 3552 2911 2922 1622 8867 6497
molecule 279010.6 2980
Apoptotic Acin1 TF IPI009182 ACINU_ B8JJ89/Q ENSMUS 56215 0.25055 0.25 2 156.402 0 0 0 0 38.6264 0 0 0 0
chromatin 19.1/IPI00 MOUSE 9JIX8 G0000002 1785 4642 2492
condensatio 922962.2 2185
n inducer in
the nucleus
Coiled-coil Soga2 UK IPI004060 CC165_M Q3UHU5 ENSMUS 68617 0.25176 1.12 8 249.901 91.7029 0 0 462.556 295.844 194.615 447.049 0 268.072

- 48 -
domain- 86.4/IPI00 OUSE G0000005 2891 4721 3975 8713 2146 3606 4062 8839
containing 761706.2 2105
protein 165
Collagen Col4a2 CS secreted IPI008309 CO4A2_ D3YV27/ ENSMUS 12827 0.25532 0.09 5 353.394 0 0 0 0 16.5393 19.9871 0 60.0349 0
alpha-2(IV) 56.1/IPI00 MOUSE P08122 G0000003 8095 7503 4324 4265 6656
chain 338452.3 1503
Hydroxyste Hsdl2 ENZ IPI009858 HSDL2_ E9PYC8/ ENSMUS 72479 0.25533 0.90 9 115.666 66.0504 121.635 0 0 105.031 0 0 77.6698 0
roid 07.1/IPI00 MOUSE Q2TPA8 G0000002 0915 3952 2107 0236 3742 4474
dehydrogen 117214.3 8383
ase-like
protein 2
Serine/argi Srrm2 TF IPI006530 SRRM2_ D3Z2W6/ ENSMUS 75956 0.26052 1.19 4 248.975 0 0 0 0 0 0 452.150 139.356 0
nine 03.1/IPI00 MOUSE Q8BTI8 G0000003 4302 8006 0373 142
repetitive 785384.2 9218
matrix
protein 2
Ankyrin-1 Ank1 CS IPI009897 ANK1_M E9QLM8/ ENSMUS 11733 0.26094 1.97 19 392.405 230.317 0 0 0 769.237 456.887 0 0 0
47.1/IPI00 OUSE F7D1P5/ G0000003 602 6975 3443 8553 7387
881305.2/ Q02357 1543
IPI007553
95.1
Protein Shroom CS IPI008812 SHRM1_ D3Z3D5/ ENSMUS 71774 0.26355 1.76 5 1849.80 1872.52 2431.79 2021.50 5620.72 8807.79 2407.61 5630.33 0 2613.52
Shroom1 1 83.1/IPI00 MOUSE Q5SX79 G0000001 6649 244 7014 3591 8549 6713 1536 4829 5744 058
115430.2 8387
Hexokinase Hk1 ENZ mitocho IPI009285 HXK1_M Q3TTB4 ENSMUS 0.26520 0.24 4 1823.11 1674.00 1155.76 0 0 211.973 0 899.136 0 0
-1 ndria 59.1 OUSE G0000003 5393 8997 338 5317 1809 4934
7012
Myosin-7B Myh7b CS muscle IPI007552 MYH7B_ A2AQP0 ENSMUS 668940 0.26520 5.17 12 0 0 560.933 420.536 0 1782.25 0 624.198 0 2668.91
00.3 MOUSE G0000007 5393 5223 6229 5367 3241 4354
4652
Collectin- Colec12 RCP IPI001293 COL12_ Q8K4Q8 ENSMUS 140792 0.26520 0.40 2 544.106 541.996 629.454 0 0 0 205.863 0 479.137 0
12 04.8 MOUSE G0000003 5393 1051 7225 7448 1849 1235
6103
Trafficking Trappc6 TP IPI001344 TPC6B_ Q9D289 ENSMUS 78232 0.26520 0.35 1 0 29.6432 79.1172 0 39.8801 0 0 27.4473 0 25.1158
protein b 26.1 MOUSE G0000002 5393 7818 2314 9207 7512 2834
particle 0993
complex
subunit 6B
Sodium Nalcn CNL IPI007423 NALCN_ Q8BXR5 338370 0.26520 2.76 1 0 0 458.616 0 0 325.247 256.645 0 304.393 378.408
leak 41.4 MOUSE 5393 6289 564 7619 1951 7555
channel
non-
selective
protein
Ras-related Rac1 SIG IPI007616 RAC1_M P63001 ENSMUS 19353 0.26520 0.25 4 188.280 0 0 150.868 379.479 120.402 61.6472 0 0 0
C3 13.1 OUSE G0000000 5393 8733 7825 8872 7917 3909
botulinum 1847
toxin
substrate 1
Isocitrate Idh1 ENZ IPI007624 IDHC_M O88844 ENSMUS 15926 0.26520 0.46 5 207.542 232.411 217.474 0 0 0 0 125.724 178.703 0
dehydrogen 52.2 OUSE G0000002 5393 8919 7663 7738 3778 3534
ase 5950
[NADP]
cytoplasmic
Protein Gm589 ENZ IPI008495 F6RMC3_ F6RMC3 ENSMUS 0.26520 0.23 2 256.825 172.715 187.972 0 0 0 39.9477 0 101.158 0
Gm5890 0 82.2 MOUSE G0000007 5393 6453 9048 4873 7831 5393

- 49 -
 8792
SRC kinase Srcin1 MOD IPI008900 SRCN1_ B1AQX6 ENSMUS 56013 0.26520 0.25 4 0 50.9925 173.541 79.0842 0 0 31.1090 0 0 45.4138
signaling 37.2 MOUSE G0000003 5393 7655 4245 884 6567 4791
inhibitor 1 8453
Leucine- Lrrc16a CS IPI010081 LR16A_ F7AI27 ENSMUS 68732 0.26520 0.18 3 318.875 125.468 567.122 0 0 90.5975 0 93.7336 0 0
rich repeat- 01.1 MOUSE G0000002 5393 2063 9439 3872 0609 0157
containing 1338
protein 16A
Guanine Gnb2 MOD IPI007567 GBB2_M D3Z1M1/ ENSMUS 14693 0.26752 0.83 6 106.736 114.974 269.215 95.1767 179.040 77.5978 85.6454 159.729 196.586 116.715
nucleotide- 66.1/IPI00 OUSE D3Z1T4 G0000002 5271 3444 1307 5163 9064 1147 0845 1023 0091 8357 5848
binding 776388.1 9713
protein
G(I)/G(S)/
G(T)
subunit
beta-2
Ras-related Rab6a TP IPI007577 RAB6A_ D3YV69/ ENSMUS 19346 0.27243 1.04 4 0 0 0 0 254.211 184.404 0 0 342.197 0
protein 48.1/IPI00 MOUSE P35279 G0000003 5838 8799 109 5648
Rab-6A 116697.1 0704
Obscurin Obscn ENZ muscle IPI008551 OBSCN_ A2AAJ9 ENSMUS 0.28333 1.34 12 0 288.150 203.844 0 0 149.393 47.8201 0 0 794.168
52.1/IPI00 MOUSE G0000006 1135 8109 0186 7879 5714 8244
459500.5 1462
Phosphoen Pck1 ENZ IPI001314 PCKGC_ Q9Z2V4 ENSMUS 18534 0.29034 0.54 6 156.938 87.9303 69.4143 153.047 0 34.6966 0 138.806 79.5966 0
olpyruvate 38.1 MOUSE G0000002 6834 9408 3508 2684 1132 672 8632 3941
carboxykin 7513
ase,
cytosolic
[GTP]
Bisphospho Bpgm ENZ IPI002216 PMGE_M P15327 ENSMUS 12183 0.29034 2.02 7 286.214 90.0888 97.8316 0 0 139.070 436.467 141.714 239.221 0
glycerate 63.5 OUSE G0000003 6834 2442 3566 4961 996 7122 029 951
mutase 8871
Probable Atp10d ENZ IPI002278 AT10D_ Q8K2X1 231287 0.29034 1.79 3 187.806 96.3860 0 0 0 45.0684 108.238 197.511 82.6131 74.4385
phospholipi 19.1 MOUSE 6834 8204 0063 6898 035 5813 731 6209
d-
transporting
ATPase
VD
Peptidyl- Fkbp5 CHA IPI003389 FKBP5_ Q64378 ENSMUS 14229 0.29034 0.53 2 2311.53 2262.18 1863.07 2433.33 0 1232.17 0 0 2345.84 1107.83
prolyl cis- 63.3 MOUSE G0000002 6834 7312 495 9217 6036 3892 6079 1985
trans 4222
isomerase
FKBP5
Translation Gcn1l1 TF IPI009878 Q8CHH7 Q8BTM7 0.29034 3.55 6 605.802 772.287 0 0 410.171 457.895 4209.34 655.878 1026.79 0
al activator 13.1 _MOUSE 6834 2677 6509 8397 8115 674 1306 3583
GCN1
Myosin-10 Myh10 CS IPI003386 MYH10_ Q5SV64/ ENSMUS 77579 0.29139 0.79 20 0 833.722 1253.98 0 608.122 603.133 108.660 1181.79 960.756 713.006
04.5/IPI00 MOUSE Q61879 G0000002 7656 363 365 176 5366 8733 9101 693 9739
515398.1 0900
Protein Gbas UK IPI001158 NIPS2_M O55126 0.29480 1.58 3 114.666 114.540 146.433 0 0 175.898 22.8749 137.248 107.976 150.721
NipSnap 27.1 OUSE 1992 5383 0324 27 7667 236 6309 4911 4031
homolog 2
40S Rpsa RIB IPI001236 RSSA_M B2CY77 ENSMUS 10050503 0.29480 0.42 3 53.6870 48.0315 104.854 239.990 191.705 72.6794 0 75.9937 0 120.587
ribosomal 04.4 OUSE G0000003 1 1992 3338 449 3383 496 497 3543 9391 1636
protein SA 2518
Beta- Eno3 ENZ IPI002285 ENOB_M P21550 ENSMUS 13808 0.29480 3.08 16 424.684 489.343 360.706 0 0 1403.93 365.603 376.876 325.745 1450.05
enolase 48.6 OUSE G0000006 1992 2118 4395 0466 4397 7159 8452 1846 1097

- 50 -
 0600
Glyceralde Gapdh ENZ IPI008749 G3P_MO F8WJL5/ ENSMUS 10004202 0.29740 0.80 28 5872.17 5604.35 1865.70 2571.06 2547.28 2104.38 2075.35 1781.04 1793.51 7030.10
hyde-3- 64.4/IPI00 USE F6QXU4/ G0000007 5 2626 1706 4255 737 8598 6802 9234 5257 3462 952 5777
phosphate 989664.1/ D3YU05/ 8162|ENS
dehydrogen IPI001231 D3Z1B7/ MUSG00
ase 76.1/IPI00 P16858 00007814
625893.3/ 2|ENSMU
IPI002736 SG000000
46.9 78965|EN
SMUSG0
00000789
67|ENSM
USG0000
0072451|E
NSMUSG
00000079
501|ENS
MUSG00
00005766
6|ENSMU
SG000000
71318|EN
SMUSG0
00000783
70|ENSM
USG0000
0079558
Succinyl- Sucla2 ENZ mitocho IPI002616 SUCB1_ Q9Z2I9 ENSMUS 20916 0.30952 0.75 14 3535.86 3983.12 3148.95 3038.58 1230.38 2485.66 926.639 3114.22 3156.78 1467.85
CoA ligase ndria 27.1 MOUSE G0000002 381 6205 5476 4193 2019 8855 068 7472 6695 1796 762
[ADP- 2110
forming]
subunit
beta,
mitochondr
ial
Succinate Sdhb TP mitocho IPI003385 DHSB_M Q9CQA3 ENSMUS 67680 0.30952 0.78 10 779.784 1068.56 915.054 917.877 346.724 660.328 284.670 727.791 936.928 538.919
dehydrogen ndria 36.1 OUSE G0000000 381 4254 1655 3429 5765 4215 7469 9616 9451 2744 2916
ase 9863
[ubiquinone
] iron-sulfur
subunit,
mitochondr
ial
Dihydrolip Dld ENZ mitocho IPI008744 DLDH_M O08749 ENSMUS 13382 0.30952 0.80 11 1146.91 1449.34 1044.02 1225.24 592.202 914.136 505.626 1045.67 1430.04 452.154
oyl ndria 56.1 OUSE G0000002 381 283 5619 0325 8913 9113 5274 755 9116 3101 9135
dehydrogen 0664
ase,
mitochondr
ial
Lumican Lum CS secreted IPI003139 LUM_M P51885 ENSMUS 17022 0.30952 0.77 7 918.555 974.505 1181.32 467.562 982.508 432.120 215.147 1146.75 963.861 716.751
00.1 OUSE G0000003 381 8951 9971 0764 4943 7007 8367 9745 5966 6707 9694
6446
Moesin Msn CS IPI001105 MOES_M P26041 ENSMUS 17698 0.30952 0.68 16 568.505 319.086 636.969 375.382 386.363 184.521 139.873 465.986 399.590 363.724
88.4 OUSE G0000003 381 1529 1086 7845 402 275 7833 2126 6914 1821 8387
1207
Actin, Actb CS IPI001108 ACTB_M Q3UGS0 ENSMUS 11461 0.30952 0.97 18 17391.4 19822.1 23810.1 20642.5 20447.3 16166.5 11253.0 19414.3 17906.0 34503.6
cytoplasmic 50.1 OUSE G0000002 381 7161 9012 963 6858 9956 4645 6825 846 323 5626

- 51 -
1 9580
Cleavage Cpsf4l TF IPI001194 Q9DBA5 Q9DBA5 ENSMUS 52670 0.30952 0.85 2 512.159 733.392 421.134 0 600.899 456.209 266.793 353.485 432.473 414.533
and 64.1 _MOUSE G0000001 381 9651 9481 8955 5787 1191 5216 4634 9045 4897
polyadenyl 8727
ation
specific
factor 4-
like
Histone Hist1h2 TF IPI002295 H2A1H_ Q8CGP6 ENSMUS 319168 0.30952 0.72 6 3063.21 5031.61 6009.61 3946.88 8187.77 2555.21 1755.01 4248.66 4499.72 5705.34
H2A type ah 44.3 MOUSE G0000006 381 0311 5893 1796 4217 1023 0352 1284 6349 314 5152
1-H 9302
Carboxylest Ces1d ENZ IPI003872 CES1D_ Q8VCT4 ENSMUS 104158 0.30952 0.72 8 1131.55 1171.36 1016.51 1282.28 775.470 600.848 352.927 1103.37 1407.04 400.280
erase 1D 89.3 MOUSE G0000005 381 0874 1987 6594 3191 0432 0878 387 6901 7869 041
6973
DNA- Polr2a TF IPI006255 RPB1_M O08847 ENSMUS 20020 0.30952 1.70 5 8629.28 6893.20 7615.09 9591.28 0 9197.92 21600.9 7626.28 13008.4 4323.83
directed 92.2 OUSE G0000000 381 125 7102 7194 5962 5572 1604 4151 2989 8443
RNA 5198
polymerase
II subunit
RPB1
Heat shock Hspa8 CHA IPI008862 HSP7C_ Q3UBR0 ENSMUS 15481 0.30952 0.77 19 1906.54 1994.47 1528.87 1303.87 1905.18 1045.72 676.181 1543.92 1276.06 2138.21
cognate 71 97.1 MOUSE G0000001 381 1091 0334 7968 325 7537 8268 957 869 4055 2898
kDa protein 5656
Histone Hist2h2 TF IPI009749 H2A2A_ F8WIX8 ENSMUS 15267 0.30952 0.71 6 3305.23 5141.08 6322.39 4075.68 8298.19 2773.62 1743.60 4411.70 4492.65 5779.15
H2A type aa1 16.1 MOUSE G0000009 381 42 9383 7997 1578 0773 3768 0208 9449 9638 0573
2-A 1383|ENS
MUSG00
00006395
4|ENSMU
SG000000
64220
Alpha- Actn1 CS IPI009899 ACTN1_ A1BN54 ENSMUS 109711 0.30952 0.66 15 475.199 341.194 872.565 239.604 614.802 342.355 136.233 334.871 225.536 633.610
actinin-1 03.1 MOUSE G0000001 381 1175 5043 4991 3613 8856 4496 7768 2831 152 0978
5143
Zinc finger Zfp219 TF IPI009899 Q924S6_ Q9CVF3 69890 0.30952 0.82 2 358.014 543.803 482.761 542.040 280.413 400.965 158.179 454.846 541.491 256.407
protein 219 70.1 MOUSE 381 7531 6156 0004 7886 8123 1988 8032 6797 0912 7323
Cell Cdc42 CS IPI001138 CDC42_ P60766/Q ENSMUS 12540 0.32428 0.89 3 0 0 31.1388 0 0 41.5051 13.8152 0 0 0
division 49.1/IPI00 MOUSE 3UL78 G0000000 7943 54 8718 261
control 986276.1 6699
protein 42
homolog
Xin actin- Xirp2 CS muscle IPI008455 XIRP2_M Q4U4S6 ENSMUS 241431 0.33211 1.72 7 0 471.771 456.136 0 0 198.989 252.716 636.227 0 509.205
binding 87.1 OUSE G0000002 1978 4475 7667 3739 0333 8565 2515
repeat- 7022
containing
protein 2
Tubulin Tubb4a CS IPI001090 TBB4A_ Q9D6F9 ENSMUS 22153 0.33211 0.37 9 362.456 341.606 416.182 0 1966.22 346.138 0 0 0 808.766
beta-4A 73.5 MOUSE G0000006 1978 5644 4687 0931 39 6235 4684
chain 2591
Catalase Cat ENZ IPI003120 CATA_M P24270 ENSMUS 12359 0.33211 1.85 13 288.413 257.094 0 0 0 265.350 291.144 267.226 187.111 0
58.6 OUSE G0000002 1978 9547 2373 3196 5659 237 913
7187
Guanine Gnat3 SIG IPI003477 GNAT3_ Q3V3I2 ENSMUS 242851 0.33211 0.47 3 422.751 281.489 414.972 314.213 0 0 0 250.226 424.103 0
nucleotide- 70.3 MOUSE G0000002 1978 4544 7754 8662 139 1422 6021
binding 8777
protein G(t)

- 52 -
subunit
alpha-3
Neuroblast Ahnak DEV IPI006058 Q6UL10_ Q6UL10 0.33211 2.05 14 0 600.751 0 688.744 0 340.312 0 829.369 936.089 541.619
differentiati 94.1 MOUSE 1978 9206 952 8049 7434 0334 643
on-
associated
protein
AHNAK
Filamin-B Flnb CS IPI006636 FLNB_M Q80X90 ENSMUS 0.33211 1.88 11 358.362 0 728.942 0 0 609.257 288.921 743.825 398.584 0
27.2 OUSE G0000002 1978 7846 9567 0266 4769 2413 4197
5278
Nesprin-2 Syne2 CS IPI008458 SYNE2_ Q6ZWQ0 ENSMUS 319565 0.33211 1.29 5 1060.29 0 185.117 0 0 395.972 187.348 527.302 494.554 0
51.1 MOUSE G0000006 1978 5777 9103 0421 6586 3368 859
3450
Unconventi Myo1c TP IPI010278 MYO1C_ F8WIE8 ENSMUS 17913 0.33211 0.45 8 296.747 100.715 393.516 0 126.772 0 0 266.320 142.258 0
onal 19.1 MOUSE G0000001 1978 7641 4307 1659 4271 9926 1127
myosin-Ic 7774
Stress-70 Hspa9 CHA mitocho IPI008808 GRP75_ Q7TSZ0/ ENSMUS 15526 0.33550 0.89 25 1389.26 1543.29 1156.12 979.377 473.209 912.622 371.883 1193.73 1592.82 866.737
protein, ndria 39.1/IPI00 MOUSE P38647 G0000002 3804 7863 8416 8239 8462 5867 3541 4938 8271 696 3037
mitochondr 133903.1 4359
ial
Importin-5 Ipo5 TP IPI004615 IPO5_MO Q9CYG6/ ENSMUS 70572 0.33889 1.19 3 254.939 0 0 88.6488 0 0 0 204.741 0 0
15.1/IPI00 USE E9PVZ5 G0000003 9942 0004 9623 8475
990594.1 0662
Propionyl- Pccb ENZ mitocho IPI004686 PCCB_M Q3UYS0 ENSMUS 66904 0.34574 0.72 8 151.734 192.070 205.361 211.066 0 91.8779 0 131.546 208.438 111.827
CoA ndria 53.4 OUSE G0000003 1826 0422 3166 7667 3165 4291 9693 4775 1761
carboxylase 2527
beta chain,
mitochondr
ial
Dihydropyr Dpysl2 DEV IPI001143 DPYL2_ O08553 ENSMUS 12934 0.34574 0.66 7 385.641 697.023 585.763 0 797.747 165.225 0 344.238 587.076 528.836
imidinase- 75.2 MOUSE G0000002 1826 4133 6213 5751 9296 1558 4943 8437 4002
related 2048
protein 2
14-3-3 Ywhah SCA IPI002273 1433F_M P68510 ENSMUS 22629 0.34574 0.81 5 829.222 974.251 1014.58 0 997.523 541.100 0 855.932 853.929 858.172
protein eta 92.5 OUSE G0000001 1826 8256 684 1131 7995 5769 3078 9958 3526
8965
Zyxin Zyx CS IPI004082 ZYX_MO Q7TQE2 ENSMUS 22793 0.34574 0.36 5 109.828 74.8807 306.149 103.815 0 0 28.7982 116.879 29.8125 39.5440
18.1 USE G0000002 1826 092 4983 6617 4939 6022 592 235 8354
9860
Serine/thre Pak6 ENZ IPI001195 PAK6_M Q3ULB5 ENSMUS 214230 0.34652 2.25 1 0 0 264.665 0 0 80.1636 159.988 0 0 355.404
onine- 08.3 OUSE G0000007 1712 2849 887 1987 7315
protein 4923
kinase PAK
6
Reticulon-4 Rtn4 DEV IPI001204 RTN4_M Q99P72 ENSMUS 68585 0.34652 2.37 2 0 106.885 0 0 0 100.602 0 109.034 43.4171 0
15.1 OUSE G0000002 1712 8739 5543 6157 8796
0458
Protein P4hb ENZ IPI001335 PDIA1_M P09103 ENSMUS 18453 0.34652 0.12 15 173.546 0 130.224 2857.60 0 0 0 0 0 372.855
disulfide- 22.2 OUSE G0000002 1712 5287 8744 1402 2335
isomerase 5130
Tubby Tub SIG IPI002233 TUB_MO P50586 ENSMUS 22141 0.34652 3.04 2 0 413.019 0 0 0 408.075 410.225 437.042 0 0
protein 74.1 USE G0000003 1712 2533 8309 492 1142
1028
Ferritin Ftl2 TP IPI002283 FRIL2_M P49945 0.34652 3.40 2 0 87.1824 0 0 0 41.1880 0 0 170.321 85.1853
light chain 79.5 OUSE 1712 6583 938 4137 5887

- 53 -
2
Phosphatid Pik3r1 SCA IPI002638 P85A_M P26450 ENSMUS 18708 0.34652 3.06 1 0 0 388.315 0 0 0 204.423 369.714 612.921 0
ylinositol 78.2 OUSE G0000004 1712 4055 7651 2446 4862
3-kinase 1417
regulatory
subunit
alpha
Cancer- Cage1 UK IPI005534 CAGE1_ Q5IR70 ENSMUS 71213 0.34652 2.86 3 0 112.091 0 0 0 110.448 84.3132 0 0 126.006
associated 83.3 MOUSE G0000004 1712 0859 6637 822 4633
gene 1 4566
protein
homolog
Microtubul Map9 CS IPI006251 MAP9_M Q3TRR0 ENSMUS 213582 0.34652 1.83 1 134.221 0 0 0 0 62.4592 37.1363 145.709 0 0
e- 51.4 OUSE G0000003 1712 128 7109 7003 5343
associated 3900
protein 9
Vacuolar Vps13d TP IPI006491 B1ART2_ B1ART1 ENSMUS 0.34652 0.37 5 537.475 738.796 0 0 247.963 0 0 0 0 558.564
protein 41.3 MOUSE G0000002 1712 8085 8421 0391 9797
sorting- 0220
associated
protein 13D
Dynein Dnah3 CS IPI008856 DYH3_M Q8BW94 ENSMUS 0.34652 2.33 7 0 0 830.999 0 0 0 357.447 912.769 668.316 0
heavy chain 78.1 OUSE G0000005 1712 6931 4258 5567 992
3, 2273
axonemal
Ras-related Rab1A MOD IPI009891 RAB1A_ H7BX41 ENSMUS 19324 0.34652 3.07 6 0 295.805 0 0 0 124.427 0 570.856 211.454 0
protein 00.1 MOUSE G0000002 1712 3243 779 564 2503
Rab-1A 0149
Cytochrom Cyb5a TP IPI009187 CYB5_M E0CY88/ ENSMUS 109672 0.34779 0.84 7 432.252 823.038 1004.16 329.303 459.968 170.429 114.192 1177.72 800.417 288.801
e b5 02.1/IPI00 OUSE G5E850 G0000002 286 3943 9482 4606 4756 9357 4665 9822 4316 5567 2558
918942.1 4646
Rho Arhgef2 MOD IPI009004 ARHG2_ Q60875 ENSMUS 16800 0.35027 0.68 3 0 96.2497 41.3080 0 0 0 0 41.8455 0 51.1830
guanine 66.4/IPI00 MOUSE G0000002 2225 8742 7572 2477 4295
nucleotide 828583.1 8059
exchange
factor 2
Arf-GAP Arap2 MOD IPI009697 ARAP2_ F7CBI4/Q ENSMUS 0.35174 0.45 7 178.917 0 0 0 57.4135 55.9587 65.4564 0 0 39.7615
with Rho- 89.1/IPI00 MOUSE 8BZ05 G0000003 0785 4231 9604 3701 4724 3926
GAP 606178.2 7999
domain,
ANK repeat
and PH
domain-
containing
protein 2
Microtubul Macf1 CS IPI008510 MACF1_ B1ARU1/ ENSMUS 11426 0.35838 0.71 17 0 0 202.755 1787.50 3096.78 784.736 0 0 2555.89 271.492
e-actin 23.3/IPI00 MOUSE Q9QXZ0 G0000002 5092 5655 8318 9734 9586 6949 9544
cross- 884482.4/ 8649
linking IPI002296
factor 1 13.4
Ankyrin Ankrd3 UK IPI009905 ANR32_ Q5XK30/ ENSMUS 105377 0.35855 3.44 3 62.5625 0 0 0 253.761 543.889 0 0 0 0
repeat 2 74.1/IPI00 MOUSE Q8R3P9 G0000002 1823 635 1236 0597
domain- 153788.5 1597
containing
protein 32
H-2 class I H2-Q10 MHC IPI004743 HA10_M Q8HWL1/ ENSMUS 15007 0.36045 0.64 3 55.1415 41.7948 0 0 0 18.2763 25.1115 34.8075 45.3688 0

- 54 -
histocompa 74.1/IPI00 OUSE P01898 G0000006 4136 676 4339 1213 1671 8837 0668
tibility 321666.1 7235
antigen,
Q10 alpha
chain
Neurofilam Nefm CS IPI008312 NFM_MO D3YZ35/ ENSMUS 18040 0.36150 0.69 8 0 0 1280.63 0 731.661 0 264.626 0 1122.85 0
ent medium 10.1/IPI00 USE P08553 G0000002 8314 1086 7777 3201 0293
polypeptide 323800.6 2054
Compleme C3 MOD secreted IPI009883 CO3_MO E1APH6/ ENSMUS 12266 0.36594 1.14 39 926.895 223.091 514.752 397.493 293.096 340.975 378.027 1057.33 441.375 459.426
nt C3 71.1/IPI00 USE P01027 G0000002 645 8999 3986 7777 5547 9265 6097 1084 3526 7701 2423
323624.4 4164
Interleukin- Il5ra RCP IPI009230 IL5RA_M B7ZN65/ ENSMUS 16192 0.36866 1.36 4 0 0 83.0269 0 124.239 140.526 0 0 0 0
5 receptor 75.1/IPI00 OUSE P21183 G0000000 712 9047 372 0575
subunit 120194.1 5364
alpha
TRIO and Triobp CS IPI006521 TARA_M Q99KW3 ENSMUS 110253 0.36947 0.76 3 0 0 0 0 70.6957 0 24.1603 0 0 83.6791
F-actin- 24.3/IPI00 OUSE G0000003 6677 8854 5229 5212
binding 875579.1 3088
protein
Electron Etfdh TP mitocho IPI008822 ETFD_M Q6PF96/ ENSMUS 66841 0.37229 0.71 23 676.741 1310.19 1100.61 1007.86 0 872.898 274.224 784.106 1147.96 554.152
transfer ndria 87.1/IPI00 OUSE Q921G7 G0000002 0387 6061 3446 6532 3759 8017 9443 1205 7783 8538
flavoprotei 121322.2 7809
n-
ubiquinone
oxidoreduct
ase,
mitochondr
ial
Cytochrom Cox7a1 ENZ mitocho IPI001131 CX7A1_ P56392 ENSMUS 12865 0.37274 0.36 1 85.0840 0 46.0409 109.598 0 38.3543 0 0 49.1581 0
e c oxidase ndria 96.1 MOUSE G0000007 807 6731 1859 1541 6463 953
subunit 4218
7A1,
mitochondr
ial
NADH Ndufb2 TP mitocho IPI001319 NDUB2_ Q9CPU2 ENSMUS 68198 0.37274 2.08 1 27.0277 0 45.5861 0 0 32.7531 0 49.2105 68.8363 0
dehydrogen ndria 94.1 MOUSE G0000000 807 1992 081 843 7507 3506
ase 2416
[ubiquinone
] 1 beta
subcomplex
subunit 2,
mitochondr
ial
Sorting and Samm5 SCA mitocho IPI002216 SAM50_ Q8BGH2 ENSMUS 68653 0.37274 0.51 2 103.796 146.248 152.166 0 0 65.2800 0 140.052 0 0
assembly 0 ndria 08.3 MOUSE G0000002 807 5675 0252 6618 6598 9067
machinery 2437
component
50 homolog
Lipase Liph ENZ secreted IPI002297 LIPH_M Q8CIV3 ENSMUS 239759 0.37274 0.43 1 0 29.6432 79.1172 0 39.8801 0 0 27.4473 35.8651 0
member H 40.2 OUSE G0000004 807 7818 2314 9207 7512 9335
4626
Ig mu chain Igh-6 IGG secreted IPI004680 IGHM_M P01872 0.37274 0.29 6 0 485.982 108.057 0 361.047 0 182.388 0 0 97.2574
C region 55.3 OUSE 807 8231 7334 4092 8744 9422
secreted
form
Tenascin-X Tnxb CS secreted IPI009876 Q3V5L4_ Q3V5L4 0.37274 0.26 5 0 441.608 218.016 0 111.421 86.4539 0 0 111.537 0
38.1 MOUSE 807 6162 7921 8118 2112 1966

- 55 -
Slit Slit2 DEV IPI001284 SLIT2_M Q9R1B9 ENSMUS 20563 0.37274 2.53 2 0 454.290 0 0 193.019 0 0 637.874 752.800 248.868
homolog 2 15.4 OUSE G0000003 807 446 1281 0584 1907 9918
protein 1558
Ferritin Ftl1 TP IPI006080 FRIL1_M Q9CPX4 ENSMUS 0.37274 0.27 2 198.798 0 89.2803 0 475.336 0 48.1035 158.997 0 0
light chain 20.4 OUSE G0000006 807 8798 5516 1381 6002 1234
1 2382|ENS
MUSG00
00005070
8
IQ motif Iqsec2 MOD IPI008303 IQEC2_M D3Z6V7 ENSMUS 245666 0.37274 2.78 3 19.9776 603.119 0 0 0 0 350.121 676.875 702.513 0
and SEC7 47.1 OUSE G0000004 807 8633 963 2485 228 9952
domain- 1115
containing
protein 2
Heterogene Hnrnpa TF IPI004661 ROA3_M E9Q7H5/ ENSMUS 229279 0.37611 1.32 9 0 82.0580 94.4285 0 152.612 0 0 71.5127 60.4683 301.052
ous nuclear 3 85.5/IPI00 OUSE F8VPW0/ G0000005 1705 117 3478 8326 6839 411 7451
ribonucleop 626666.5/ Q8BG05 9179|ENS
rotein A3 IPI009882 MUSG00
95.1 00006848
0|ENSMU
SG000000
59005
Methylcrot Mccc2 ENZ mitocho IPI005537 MCCB_M Q3ULD5/ ENSMUS 78038 0.37931 1.13 11 247.534 186.524 148.013 223.230 0 158.900 0 185.325 337.968 0
onoyl-CoA ndria 17.6/IPI00 OUSE Q8K1L7 G0000002 3556 0157 4957 1215 3217 4635 8268 6551
carboxylase 988940.1 1646
beta chain,
mitochondr
ial
Fibulin-2 Fbln2 CS secreted IPI008305 FBLN2_ D3YUI9 0.38862 0.63 1 0 273.670 326.488 358.116 0 196.088 138.336 0 0 269.991
71.1 MOUSE 9493 9016 3227 1738 4378 0882 1137
Cytoplasmi Dync1h CS IPI001198 DYHC1_ Q9JHU4 ENSMUS 13424 0.38862 0.22 7 544.220 446.308 423.544 0 0 32.9095 0 0 237.717 38.8712
c dynein 1 1 76.2 MOUSE G0000001 9493 2937 9661 4809 5948 3022 0731
heavy chain 8707
1
Exostosin- Extl1 ENZ IPI001234 EXTL1_ Q9JKV7 ENSMUS 56219 0.38862 3.03 1 152.893 172.653 223.751 0 0 428.326 0 636.694 599.559 0
like 1 91.2 MOUSE G0000002 9493 3118 2965 05 6785 978 9368
8838
Xylosyltran Xylt2 ENZ IPI002288 XYLT2_ Q3UCI0 ENSMUS 217119 0.38862 0.60 2 857.122 696.833 0 0 606.482 0 186.037 0 572.580 543.959
sferase 2 10.2 MOUSE G0000002 9493 8058 9642 0853 6508 1422 4184
0868
Hydroceph Hydin UK IPI003191 HYDIN_ Q80W93 ENSMUS 244653 0.38862 0.32 6 183.900 139.332 81.7440 0 0 0 17.9349 51.5435 61.4742 0
alus- 67.7 MOUSE G0000005 9493 632 829 0764 8902 1272 9156
inducing 9854
protein
Transformi Tacc2 CS IPI004655 E9Q8T1_ Q2VPC8 ENSMUS 57752 0.38862 0.63 3 547.078 570.304 439.634 0 0 397.465 0 299.901 283.855 0
ng acidic 85.1 MOUSE G0000003 9493 3918 5182 8308 2775 6501 0517
coiled-coil- 0852
containing
protein 2
Olfactory Olfr124 RCP IPI004669 Q8VG61_ Q8VG61 0.38862 0.39 1 102.772 0 0 167.134 162.103 58.0980 46.7838 0 61.7397 0
receptor 6 71.4 MOUSE 9493 3842 6564 3743 3482 1108 2807
1246
Protein Gm158 ENZ IPI007628 E9PX61_ Q8BYX4 ENSMUS 0.38862 4.53 5 84.9710 119.294 0 56.2454 0 433.420 280.224 0 0 467.454
Gm15800 00 14.3 MOUSE G0000004 9493 3281 7253 3446 2753 1916 1916
(Probable 2744
E3

- 56 -
ubiquitin-
protein
ligase
C12orf51)
UPF0428 UK IPI009895 CX056_M E9Q0G3/ ENSMUS 77644 0.39199 0.46 2 355.761 0 0 0 0 68.8827 0 77.0273 345.505 0
protein 88.1/IPI00 OUSE Q8VDP2 G0000004 0117 7349 048 0572 6386
CXorf56 123617.5 8188|ENS
homolog MUSG00
00000642
3
Ig gamma- IGG secreted IPI010231 GCAB_M F6TQW2/ ENSMUS 0.39587 0.68 4 0 0 0 0 1273.57 983.602 0 745.486 0 0
2A chain C 20.1/IPI00 OUSE P01864 G0000007 9882 6704 4824 4171
region 831380.1 6612
secreted
form
ATP Atp5o TP mitocho IPI001189 ATPO_M Q9DB20 ENSMUS 10004742 0.39761 1.78 4 167.636 258.572 139.750 0 0 181.094 88.6703 302.282 0 436.816
synthase ndria 86.1 OUSE G0000002 9 4752 5026 5984 8329 9199 2979 0481 2383
subunit O, 2956
mitochondr
ial
NADH Ndufs7 ENZ mitocho IPI001202 NDUS7_ Q9DC70 ENSMUS 75406 0.39761 0.62 4 55.2638 141.432 77.1561 126.531 0 96.3247 0 32.2569 117.918 0
dehydrogen ndria 32.1 MOUSE G0000002 4752 1791 4266 8892 6569 2072 2561 7561
ase 0153
[ubiquinone
] iron-sulfur
protein 7,
mitochondr
ial
Up- Usmg5 SCA mitocho IPI006246 USMG5_ Q78IK2 ENSMUS 10050491 0.39761 1.71 1 88.7945 70.2358 67.5713 0 0 128.152 33.7483 76.2926 0 149.719
regulated ndria 53.1 MOUSE G0000007 2 4752 3919 3912 9272 818 9157 0115 5183
during 1528
skeletal
muscle
growth
protein 5
Compleme C1qbp MOD mitocho IPI007757 C1QBP_ O35658 0.39761 1.44 2 189.542 0 0 56.0902 55.4850 64.1368 83.0906 126.781 159.162 0
nt ndria 83.1 MOUSE 4752 531 861 1415 4755 1307 7508 78
component
1Q
subcompon
ent-binding
protein,
mitochondr
ial
Collagen Col5a1 CS secreted IPI001286 CO5A1_ O88207 ENSMUS 12831 0.39761 1.37 12 636.024 0 529.178 0 0 124.020 148.745 265.560 711.181 352.397
alpha-1(V) 89.2 MOUSE G0000002 4752 0286 0608 9503 9064 8339 1449 8896
chain 6837
Collagen Col24a1 CS secreted IPI005512 COOA1_ Q30D77 ENSMUS 71355 0.39761 1.19 5 77.0652 0 0 410.496 0 29.8523 18.7662 65.9724 85.8618 381.869
alpha- 34.7 MOUSE G0000002 4752 6634 965 8729 1869 3566 5284 2915
1(XXIV) 8197
chain
LIM/homeo Lhx2 TF IPI001293 LHX2_M Q9Z0S2 ENSMUS 16870 0.39761 0.61 2 897.964 459.388 561.117 637.384 0 0 0 505.148 675.343 371.093
box protein 85.1 OUSE G0000000 4752 1105 256 0556 5438 8847 9945 8696
Lhx2 0247
Uncharacte UK IPI007536 K1755_M A2AC60 ENSMUS 228846 0.39761 2.36 5 159.121 0 94.7416 141.636 0 94.9137 137.857 508.155 191.122 0
rized 77.1 OUSE G0000003 4752 1856 4881 4131 6828 0751 0502 2221
protein 7813

- 57 -
KIAA1755
homolog
Vacuolar Vps13a TP IPI004203 VP13A_ Q5H8C4 ENSMUS 271564 0.40315 0.80 6 137.567 136.535 0 0 0 101.273 118.145 0 0 0
protein 94.4/IPI00 MOUSE G0000004 2403 8835 3386 6278 2083
sorting- 762748.2 6230
associated
protein 13A
Elongation Tufm TF mitocho IPI002744 EFTU_M Q8BFR5 ENSMUS 233870 0.40828 0.74 25 1090.36 1179.38 924.588 761.988 0 669.536 326.572 1130.94 1012.15 505.576
factor Tu, ndria 07.1/IPI00 OUSE G0000007 0015 7517 4235 495 2455 7829 9807 8738 098 7199
mitochondr 460132.1 3838
ial
E3 Ubr4 ENZ IPI008455 UBR4_M A2AN08 ENSMUS 69116 0.40870 1.81 3 124.072 118.803 0 0 95.2153 0 0 202.642 0 204.272
ubiquitin- 83.3/IPI00 OUSE G0000006 3904 7845 9241 7974 7755 7012
protein 845523.1 6036
ligase
UBR4
Parathymos Ptms MOD IPI004593 PTMS_M Q8VDQ2/ ENSMUS 69202 0.40934 1.18 4 165.232 127.455 243.420 0 126.953 127.288 0 231.725 227.213 0
in 26.1/IPI00 OUSE Q9D0J8 G0000003 5181 4408 5909 0336 4836 843 9931 501
471441.1 0122
Voltage- Cacna1 CNL IPI009747 CAC1B_ A2AIR7/ ENSMUS 12287 0.41148 0.25 5 193.463 0 0 0 0 48.9537 34.4285 0 0 62.0130
dependent b 14.1/IPI00 MOUSE A2AIS0/ G0000000 1575 3084 4904 4383 3071
N-type 625414.2/ O55017 4113
calcium IPI001150
channel 62.3
subunit
alpha-1B
Piezo-type Piezo2 CNL IPI009736 PIEZ2_M Q8CD54 ENSMUS 667742 0.41999 0.78 3 0 311.531 0 0 309.571 120.895 0 354.935 253.202 0
mechanose 21.1/IPI00 OUSE G0000004 8866 6159 5909 4748 6086 9391
nsitive ion 975121.1 1482
channel
component
2
Long- Acsl1 ENZ mitocho IPI001125 ACSL1_ P41216 ENSMUS 14081 0.42063 0.77 17 1283.08 1569.05 1671.14 1695.62 688.269 1306.32 456.952 1232.42 1744.56 580.145
chain-fatty- ndria 49.2 MOUSE G0000001 4921 3055 3334 8763 3289 6399 2802 5013 6782 7345 1059
acid--CoA 8796
ligase 1
ADP/ATP Slc25a5 TP mitocho IPI001278 ADT2_M P51881 ENSMUS 11740 0.42063 1.20 8 699.422 686.231 1770.73 781.605 686.298 1078.59 515.008 877.113 1235.08 1833.33
translocase ndria 41.3 OUSE G0000001 4921 07 346 6569 7005 9726 6867 8715 3351 9103 5432
2 6319
CDGSH Cisd1 TP mitocho IPI001283 CISD1_M Q91WS0 ENSMUS 52637 0.42063 0.80 4 183.698 197.924 161.978 221.157 156.577 227.899 71.6441 162.615 158.908 120.248
iron-sulfur ndria 46.1 OUSE G0000003 4921 3922 4974 4546 7456 331 5702 6836 1015 4662 5464
domain- 7710
containing
protein 1
NADH Ndufb4 TP mitocho IPI001323 NDUB4_ Q9CQC7 ENSMUS 10004127 0.42063 0.77 5 320.631 282.262 149.516 162.244 28.1391 117.294 57.4975 153.264 262.289 131.668
dehydrogen ndria 90.5 MOUSE G0000002 3 4921 067 961 2192 1126 3468 2227 7537 5977 526 0937
ase 2820
[ubiquinone
] 1 beta
subcomplex
subunit 4;
AltName:
Full=Comp
lex I-B15;
Short=CI-
B15;
AltName:

- 58 -
Full=NAD
H-
ubiquinone
oxidoreduct
ase B15
subunit;
Medium- Acadm ENZ mitocho IPI001349 ACADM_ P45952 ENSMUS 11364 0.42063 0.78 13 2582.30 2942.40 1984.79 1721.35 723.790 1413.88 581.739 2365.83 2208.59 1189.61
chain ndria 61.1 MOUSE G0000006 4921 0962 6295 1556 6894 5879 4362 4321 7594 8292 3052
specific 2908
acyl-CoA
dehydrogen
ase,
mitochondr
ial
Acetyl- Acat1 ENZ mitocho IPI001540 THIL_M Q8QZT1 ENSMUS 110446 0.42063 0.81 14 2333.21 2640.86 2506.35 2286.50 1182.53 1779.46 830.680 2332.89 2829.27 1150.40
CoA ndria 54.1 OUSE G0000003 4921 6352 9757 5159 4203 5855 7323 7869 9666 9448 2488
acetyltransf 2047
erase,
mitochondr
ial
Succinate Sdha ENZ mitocho IPI002303 DHSA_M Q8K2B3 ENSMUS 66945 0.42063 0.84 22 1640.26 1875.03 1628.47 1165.08 824.366 1730.99 477.275 1524.94 1460.42 786.215
dehydrogen ndria 51.1 OUSE G0000002 4921 9985 5289 0283 4878 1315 2337 9061 0588 8835 7001
ase 1577
[ubiquinone
]
flavoprotei
n subunit,
mitochondr
ial
ATP Atp5h TP mitocho IPI008817 ATP5H_ B1ASE2 ENSMUS 71679 0.42063 1.74 6 117.016 143.849 171.755 0 176.080 250.320 75.0248 182.964 86.7835 465.551
synthase ndria 99.1 MOUSE G0000003 4921 6269 3889 2493 4065 3193 2709 3553 59 5098
subunit d, 4566
mitochondr
ial
Voltage- Vdac2 CNL mitocho IPI010267 VDAC2_ G3UX26 ENSMUS 22334 0.42063 0.93 4 482.684 365.063 356.784 366.554 182.346 275.044 264.974 455.611 346.687 286.053
dependent ndria 12.1 MOUSE G0000002 4921 499 2398 2869 9748 9307 1772 546 4544 2334 1972
anion- 1771
selective
channel
protein 2
Microfibril- Mfap4 CS secreted IPI001337 MFAP4_ Q9D1H9 ENSMUS 76293 0.42063 0.70 3 378.226 222.809 398.995 0 209.230 121.705 67.3289 374.208 210.213 73.1805
associated 51.1 MOUSE G0000004 4921 8381 945 4273 1348 6019 8399 5087 2688 8926
glycoprotei 2436
n4
Collagen Col3a1 CS secreted IPI009907 CO3A1_ Q3TW25 ENSMUS 12825 0.42063 0.69 22 1625.14 1089.35 1381.76 1073.95 736.246 267.953 224.192 858.995 1430.19 1295.15
alpha-1(III) 26.1 MOUSE G0000002 4921 585 3369 9654 4236 9404 8743 7051 8528 4673 0061
chain 6043
Tubulin Tubb5 CS IPI001173 TBB5_M P99024 ENSMUS 22154 0.42063 0.52 10 588.275 461.689 745.424 357.519 2494.14 409.759 202.372 433.470 552.758 821.789
beta-5 52.1 OUSE G0000000 4921 2203 3152 6981 685 6242 495 7914 3757 5875 7393
chain 1525
Leucine- Lrrc34 UK IPI001188 LRC34_ Q9DAM1 ENSMUS 71827 0.42063 0.79 1 371.591 312.570 556.371 0 487.403 338.754 104.459 285.929 150.363 477.489
rich repeat- 20.1 MOUSE G0000002 4921 8292 0019 2744 7104 2026 0026 0319 9857 8545
containing 7702
protein 34
Decorin Dcn CS IPI001231 PGS2_M P28654 ENSMUS 13179 0.42063 0.81 5 856.818 632.752 961.237 646.704 863.019 434.471 203.536 958.148 775.724 822.599
96.1 OUSE G0000001 4921 1362 6294 5178 7734 1582 8705 1451 7512 5917 0535
9929

- 59 -
Tubulin Tubb4b CS IPI001694 TBB4B_ Q9DCR1 ENSMUS 227613 0.42063 0.67 11 701.680 612.925 786.300 0 2420.48 500.769 270.548 575.262 599.723 1105.19
beta-4B 63.1 MOUSE G0000003 4921 4913 7676 8676 2611 253 3875 5909 5692 2487
chain 6752
Band 3 Slc4a1 TP IPI002305 B3AT_M P04919 ENSMUS 20533 0.42063 1.24 10 898.209 450.433 554.358 419.922 0 521.447 1007.07 561.550 574.377 220.893
anion 94.1 OUSE G0000000 4921 5426 5427 313 2152 1301 8206 5943 3779 2851
transport 6574
protein
Tubulin Tuba1c CS IPI004038 TBA1C_ Q52L87 ENSMUS 22146 0.42063 0.66 7 786.030 942.622 1306.94 697.190 1819.33 498.179 191.712 848.083 948.853 1157.31
alpha-1C 10.2 MOUSE G0000004 4921 3573 9119 8295 3905 1994 9373 408 7016 3536 6617
chain 3091
Diacylglyce Dgkk ENZ IPI004539 Q6DIC8_ E9Q7N4 ENSMUS 331374 0.42063 9.22 4 385.811 294.586 419.394 524.906 28.0343 282.890 5121.57 9050.07 488.084 296.562
rol kinase 53.2 MOUSE G0000006 4921 7726 2513 9606 3824 1078 7327 4343 9764 6203 9138
kappa 2393
Phosphoglu Pgm1 ENZ IPI005551 PGM1_M Q9D0F9 ENSMUS 72157 0.42063 0.90 14 532.140 494.908 404.382 372.264 0 348.774 188.683 279.864 273.874 530.392
comutase-1 40.3 OUSE G0000002 4921 2037 5458 5865 6047 4176 4502 9397 0189 8236
5791
Protein Olfr704 RCP IPI008742 D3YVL6_ D3YVL6 ENSMUS 0.42063 1.42 1 0 157.034 267.658 493.955 91.8122 216.654 124.596 307.911 540.269 248.332
Olfactory 91.1 MOUSE G0000007 4921 4585 8623 9743 0659 2114 0397 5677 7295 1015
receptor 3900
Olfr704
Nitrogen Nprl3 MOD IPI008816 NPRL3_ A7M7S2 ENSMUS 17168 0.42063 0.81 1 181.689 154.799 133.463 131.125 161.208 90.2483 60.6922 151.565 163.050 148.130
permease 75.1 MOUSE G0000002 4921 1736 3255 2497 6356 0987 3819 9512 3297 963 1912
regulator 3- 0289
like protein
N- Pigl ENZ IPI009887 PIGL_M Q6ZQM6 ENSMUS 327942 0.42063 1.96 1 7841.96 7239.45 3463.39 13617.3 5910.79 16353.7 23656.6 5972.32 26325.4 2308.42
acetylgluco 67.1 OUSE G0000001 4921 9505 8865 3934 7898 0554 4625 9943 6022 051 9668
saminyl- 4245
phosphatid
ylinositol
de-N-
acetylase
Protein Cyp2j9 ENZ IPI009910 Q9CRQ9_ Q9CRQ9 0.42063 0.86 1 0 466.253 303.793 385.434 344.474 217.437 125.115 319.122 278.073 347.297
Cyp2j9 61.1 MOUSE 4921 0585 0825 283 2279 6441 7631 4835 9483 758
(Cytochrom
e P450
CYP2J9)
Ig kappa Gm108 IGG DELET IPI008304 KV5A9_ P01642 0.42371 0.00 1 0 388.307 0 0 0 0 0 0 0 0
chain V-V 81 ED 50.1 MOUSE 0797 6913
region L7
Protein Gm176 UK DELET IPI009880 E9PVI9_ E9PVI9 ENSMUS 0.42371 0.00 3 354.340 0 0 0 0 0 0 0 0 0
Gm17695 95 ED 01.1 MOUSE G0000009 0797 2859
0689
ATP Mtatp8 TP mitocho IPI001168 ATP8_M P03930 ENSMUS 17706 0.42371 0.00 1 87.8510 0 0 0 0 0 0 0 0 0
synthase ndria 96.1 OUSE G0000006 0797 0863
protein 8 4356
Dynamin- Opa1 MOD mitocho IPI001176 OPA1_M Q8BGW2 ENSMUS 74143 0.42371 0.39 8 178.421 0 0 0 0 0 0 68.9508 0 0
like 120 ndria 57.2/IPI00 OUSE /E0CXD1 G0000004 0797 7983 5718
kDa 918878.1 7731|ENS
protein, MUSG00
mitochondr 00003808
ial 4
Mitochondr Timm2 TP mitocho IPI001237 TIM23_M Q9WTQ8 0.42371 1000.00 1 0 0 0 0 0 41.2991 0 0 0 0
ial import 3 ndria 12.1 OUSE 0797 1444
inner
membrane
translocase

- 60 -
subunit
Tim23
Acyl- Acot10 ENZ mitocho IPI001272 ACO10_ Q32MW3 ENSMUS 64833 0.42371 1000.00 1 0 0 0 0 0 8.12805 0 0 0 0
coenzyme ndria 60.2 MOUSE G0000004 0797 345
A 7565
thioesterase
10,
mitochondr
ial
L-2- L2hgdh ENZ mitocho IPI001303 L2HDH_ Q91YP0 ENSMUS 217666 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 29.7936
hydroxyglu ndria 31.3 MOUSE G0000002 0797 7289
tarate 0988
dehydrogen
ase,
mitochondr
ial
ES1 protein D10Jhu UK mitocho IPI001332 ES1_MO Q9D172 ENSMUS 10004668 0.42371 1000.00 4 0 0 0 0 0 177.746 0 274.080 0 0
homolog, 81e ndria 84.1/IPI00 USE G0000005 4 0797 2713 4281
mitochondr 853761.1 3329
ial
Adrenodoxi Fdx1 TP mitocho IPI001359 ADX_MO P46656 ENSMUS 14148 0.42371 1000.00 3 0 0 0 0 0 0 0 0 0 412.975
n, ndria 39.1 USE G0000003 0797 0224
mitochondr 2051
ial
Cholesterol Cyp11a ENZ mitocho IPI001369 CP11A_ Q9QZ82 ENSMUS 13070 0.42371 1000.00 6 0 0 0 0 0 0 0 0 0 496.970
side-chain 1 ndria 28.3 MOUSE G0000003 0797 4497
cleavage 2323
enzyme,
mitochondr
ial
Amine Maoa ENZ mitocho IPI001697 AOFA_M Q64133 ENSMUS 17161 0.42371 0.00 1 0 0 0 192.416 0 0 0 0 0 0
oxidase ndria 11.2 OUSE G0000002 0797 1989
[flavin- 5037
containing]
A
NADH Ndufs8 ENZ mitocho IPI001700 NDUS8_ Q8K3J1 ENSMUS 225887 0.42371 1000.00 2 0 0 0 0 0 0 0 0 425.219 0
dehydrogen ndria 93.3 MOUSE G0000005 0797 4905
ase 9734
[ubiquinone
] iron-sulfur
protein 8,
mitochondr
ial
39S Mrpl22 RIB mitocho IPI002253 RM22_M Q8BU88 ENSMUS 216767 0.42371 1000.00 2 0 0 0 0 0 0 61.4851 0 0 0
ribosomal ndria 18.3 OUSE G0000002 0797 9871
protein 0514
L22,
mitochondr
ial
Apoptosis- Aifm2 ENZ mitocho IPI002254 AIFM2_ Q8BUE4 ENSMUS 71361 0.42371 0.00 3 60.5844 0 0 0 0 0 0 0 0 0
inducing ndria 07.1 MOUSE G0000002 0797 2101
factor 2 0085
Twinkle Peo1 ENZ mitocho IPI002299 PEO1_M Q8CIW5 ENSMUS 226153 0.42371 1000.00 1 0 0 0 0 0 0 0 0 1008.37 0
protein, ndria 39.1 OUSE G0000002 0797 0918
mitochondr 5209
ial
NADH Ndufa1 TP mitocho IPI002307 NDUAD_ Q9ERS2 ENSMUS 67184 0.42371 0.00 2 77.3114 0 0 0 0 0 0 0 0 0

- 61 -
dehydrogen 3 ndria 15.5 MOUSE G0000003 0797 1755
ase 6199
[ubiquinone
] 1 alpha
subcomplex
subunit 13
Succinate- Aldh5a ENZ mitocho IPI002731 SSDH_M Q8BWF0 ENSMUS 214579 0.42371 0.00 1 0 0 502.825 0 0 0 0 0 0 0
semialdehy 1 ndria 64.1 OUSE G0000003 0797 0944
de 5936
dehydrogen
ase,
mitochondr
ial
Coiled-coil- Chchd2 UK mitocho IPI002849 CHCH2_ Q9D1L0 ENSMUS 14004 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 24.3382
helix- ndria 25.3 MOUSE G0000007 0797 6762
coiled-coil- 0493
helix
domain-
containing
protein 2,
mitochondr
ial
Mitochondr Tomm2 TP mitocho IPI003151 TOM22_ Q9CPQ3 ENSMUS 223696 0.42371 1000.00 1 0 0 0 0 0 12.8594 0 0 0 0
ial import 2 ndria 35.3 MOUSE G0000002 0797 7702
receptor 2427
subunit
TOM22
homolog
Solute Slc25a4 TP mitocho IPI003205 S2542_M Q8R0Y8 ENSMUS 73095 0.42371 1000.00 2 0 0 0 0 0 28.9868 0 0 0 0
carrier 2 ndria 03.2 OUSE G0000000 0797 8349
family 25 2346
member 42
2- Bckdha ENZ mitocho IPI003315 ODBA_M Q99L69 0.42371 0.00 1 0 0 31.7168 0 0 0 0 0 0 0
oxoisovaler ndria 55.2 OUSE 0797 436
ate
dehydrogen
ase subunit
alpha,
mitochondr
ial
2- Ogdhl ENZ mitocho IPI003426 E9Q7L0_ E9Q7L0 ENSMUS 239017 0.42371 1000.00 4 0 0 0 0 0 0 324.045 0 0 0
oxoglutarat ndria 03.7 MOUSE G0000002 0797 5877
e 1913
dehydrogen
ase-like,
mitochondr
ial
NADH Ndufv3 TP mitocho IPI004033 NDUV3_ Q8BK30 ENSMUS 78330 0.42371 0.00 1 44.2262 0 0 0 0 0 0 0 0 0
dehydrogen ndria 81.1 MOUSE G0000002 0797 4508
ase 4038
[ubiquinone
]
flavoprotei
n 3,
mitochondr
ial
Uncharacte Gm141 UK mitocho IPI004073 CO062_M Q8CE97 623781 0.42371 1000.00 1 0 0 0 0 0 0 0 204.262 0 0

- 62 -
rized 37 ndria 24.1 OUSE 0797 6996
protein
C15orf62
homolog,
mitochondr
ial
NADPH:ad Fdxr TP mitocho IPI004539 ADRO_M Q61578 ENSMUS 14149 0.42371 1000.00 10 0 0 0 0 0 0 0 0 0 1150.95
renodoxin ndria 81.3 OUSE G0000001 0797 7228
oxidoreduct 8861
ase,
mitochondr
ial
UPF0598 UK mitocho IPI004608 CH082_M Q9D1W4 ENSMUS 223665 0.42371 0.00 1 28.0304 0 0 0 0 0 0 0 0 0
protein ndria 53.1 OUSE G0000007 0797 434
C8orf82 9002
homolog
Acetyl- Acss1 ENZ mitocho IPI004699 ACS2L_ Q569W4 ENSMUS 68738 0.42371 1000.00 3 0 0 0 0 0 0 0 0 83.6376 0
coenzyme ndria 42.2 MOUSE G0000002 0797 6973
A 7452
synthetase
2-like,
mitochondr
ial
Mitochondr Msra ENZ mitocho IPI004753 MSRA_M Q9D6Y7 ENSMUS 110265 0.42371 0.00 1 28.0182 0 0 0 0 0 0 0 0 0
ial peptide ndria 22.1 OUSE G0000005 0797 8579
methionine 4733
sulfoxide
reductase
3 beta- Hsd3b3 ENZ mitocho IPI006491 3BHS3_ B1ARP0 ENSMUS 15494 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 317.153
hydroxyster ndria 26.1 MOUSE G0000006 0797 2981
oid 2410
dehydrogen
ase/Delta 5-
->4-
isomerase
type 3
Peripheral- Bzrap1 UK mitocho IPI006495 RIMB1_ Q5NCP6 ENSMUS 207777 0.42371 0.00 2 151.839 0 0 0 0 0 0 0 0 0
type ndria 25.1 MOUSE G0000003 0797 8579
benzodiaze 4156
pine
receptor-
associated
protein 1
Adenylate Ak4 ENZ mitocho IPI006518 KAD4_M Q3UYL0 ENSMUS 11639 0.42371 0.00 1 0 0 28.0654 0 0 0 0 0 0 0
kinase ndria 78.1 OUSE G0000002 0797 7998
isoenzyme 8527
4,
mitochondr
ial
NADH Ndufc2 TP mitocho IPI006628 NDUC2_ Q9CQ54 ENSMUS 675851 0.42371 1000.00 3 0 0 0 0 0 0 0 0 230.534 0
dehydrogen ndria 61.1 MOUSE G0000003 0797 4703
ase 0647
[ubiquinone
] 1 subunit
C2
ATP- Abcb7 TP mitocho IPI006726 ABCB7_ Q61102 ENSMUS 11306 0.42371 0.00 1 0 0 0 959.302 0 0 0 0 0 0
binding ndria 63.3 MOUSE G0000003 0797 93

- 63 -
cassette 1333
sub-family
B member
7,
mitochondr
ial
Methylmal Mmadh ?MOD? mitocho IPI007504 MMAD_ A2AQT8 ENSMUS 109129 0.42371 1000.00 1 0 0 0 0 0 0 530.369 0 0 0
onic c ndria 97.1 MOUSE G0000002 0797 2142
aciduria 6766
and
homocystin
uria type D
homolog,
mitochondr
ial
Peroxiredo Prdx5 ENZ mitocho IPI007599 PRDX5_ P99029 ENSMUS 54683 0.42371 1000.00 1 0 0 0 0 0 0 0 216.983 0 0
xin-5, ndria 99.1 MOUSE G0000002 0797 3062
mitochondr 4953
ial
Acyl- Acsm3 ENZ mitocho IPI007624 ACSM3_ Q3UNX5 ENSMUS 20216 0.42371 0.00 1 0 0 49.8519 0 0 0 0 0 0 0
coenzyme ndria 78.1 MOUSE G0000003 0797 5857
A 0935
synthetase
ACSM3,
mitochondr
ial
Ornithine Otc ENZ mitocho IPI007762 OTC_MO Q8R1A8 ENSMUS 18416 0.42371 0.00 1 0 91.1187 0 0 0 0 0 0 0 0
carbamoyltr ndria 57.1 USE G0000003 0797 9445
ansferase, 1173
mitochondr
ial
Uncharacte UK mitocho IPI008311 CX023_M A2AG58 ENSMUS 382252 0.42371 0.00 2 0 0 163.766 0 0 0 0 0 0 0
rized ndria 75.2 OUSE G0000004 0797 5277
protein 4150
CXorf23
homolog
Peptidyl- Ptrh2 ENZ mitocho IPI008539 PTH2_M Q8R2Y8 ENSMUS 217057 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 177.433
tRNA ndria 67.1 OUSE G0000007 0797 8362
hydrolase 2582
2,
mitochondr
ial
Reticulon- Rtn4ip1 DEV mitocho IPI008580 RT4I1_M D3Z792 ENSMUS 170728 0.42371 1000.00 1 0 0 0 0 0 0 0 0 52.2143 0
4- ndria 50.1 OUSE G0000001 0797 649
interacting 9864
protein 1,
mitochondr
ial
DNA- Polrmt TF mitocho IPI008810 RPOM_M E0CY15 ENSMUS 216151 0.42371 0.00 1 0 528.804 0 0 0 0 0 0 0 0
directed ndria 34.1 OUSE G0000002 0797 7234
RNA 0329
polymerase,
mitochondr
ial
NFU1 iron- Nfu1 SCA mitocho IPI008815 NFU1_M Q9QZ23 ENSMUS 56748 0.42371 0.00 1 27.4209 0 0 0 0 0 0 0 0 0
sulfur ndria 09.2 OUSE G0000002 0797 8316
cluster 9993

- 64 -
scaffold
homolog,
mitochondr
ial
Chloride Clic4 CNL mitocho IPI008946 CLIC4_M Q3U8I1/Q ENSMUS 29876 0.42371 0.00 2 27.5144 0 109.291 0 0 0 0 0 0 0
intracellular ndria 94.1/IPI00 OUSE 9QYB1 G0000003 0797 8625 6727
channel 135977.3 7242
protein 4
Acyl carrier Ndufab TP mitocho IPI009180 ACPM_M F6ZFT1 ENSMUS 70316 0.42371 0.00 2 76.4729 0 0 0 0 0 0 0 0 0
protein 1 ndria 79.1 OUSE G0000003 0797 6493
0869
FAD- Foxred1 ENZ mitocho IPI009281 FXRD1_ D6RJ42 ENSMUS 235169 0.42371 1000.00 1 0 0 0 0 0 110.646 0 0 0 0
dependent ndria 07.1 MOUSE G0000003 0797 4486
oxidoreduct 9048
ase domain-
containing
protein 1
Kinesin- Klp6 TP mitocho IPI009285 KLP6_M D3YXS5 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 25.9260 0 0 0
like protein ndria 36.1 OUSE G0000008 0797 3569
KLP6 7236
Cytochrom Cyp11b ENZ mitocho IPI009869 Q3TR45_ Q3TR45 0.42371 1000.00 4 0 0 0 0 0 0 0 0 0 275.289
e P450 1 ndria 04.1 MOUSE 0797 775
11B1,
mitochondr
ial
Hydroxyac Hagh ENZ mitocho IPI009886 GLO2_M E9PYA3 ENSMUS 14651 0.42371 0.00 2 36.9454 0 0 0 0 0 0 0 0 0
ylglutathion ndria 43.1 OUSE G0000002 0797 4418
e hydrolase, 4158
mitochondr
ial
[Pyruvate Pdk4 ENZ mitocho IPI001194 PDK4_M O70571 ENSMUS 27273 0.42371 1000.00 1 0 0 0 0 0 0 0 76.9480 0 0
dehydrogen ndrial 31.1 OUSE G0000001 0797 1276
ase 9577
[lipoamide]
] kinase
isozyme 4,
mitochondr
ial
Troponin I, Tnni3 MOD muscle IPI002231 TNNI3_M P48787 ENSMUS 21954 0.42371 0.00 3 0 0 184.749 0 0 0 0 0 0 0
cardiac 97.5 OUSE G0000003 0797 4984
muscle 5458
Myosin Myl6b TP muscle IPI002616 MYL6B_ Q8CI43 ENSMUS 216459 0.42371 0.00 2 0 409.897 0 0 0 0 0 0 0 0
light chain 38.1 MOUSE G0000003 0797 0001
6B 9824
Troponin Tnnc2 MOD muscle IPI002841 TNNC2_ A2A4Z2 ENSMUS 21925 0.42371 1000.00 2 0 0 0 0 0 348.337 0 0 0 0
C, skeletal 19.7 MOUSE G0000001 0797 0705
muscle 7300
Cat eye Cecr2 MOD muscle IPI003446 E9Q2Z1_ Q6ZPI9 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 40.0563 0 0
syndrome 41.6 MOUSE G0000007 0797 3722
critical 1226
region
protein 2
Myosin- Mybpc1 CS muscle IPI003967 Q6P6L5_ Q6P6L5 ENSMUS 109272 0.42371 1000.00 8 0 0 0 0 0 0 0 0 0 631.972
binding 74.1 MOUSE G0000002 0797 7608
protein C, 0061
slow-type

- 65 -
Selenoprote Sepn1 UK muscle IPI006247 D3Z2R5_ D3Z2R5 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 175.874 0
in N 92.2 MOUSE G0000005 0797 4136
0989
Nebulette Nebl CS muscle IPI007518 B7ZCI2_ B7ZCI2 ENSMUS 0.42371 1000.00 2 0 0 0 0 0 0 0 924.478 0 0
06.3 MOUSE G0000005 0797 5006
3702
Caldesmon Cald1 CS muscle IPI007576 D3Z6I7_ F6ZAW1 ENSMUS 0.42371 0.00 5 0 0 192.623 0 0 0 0 0 0 0
35.1 MOUSE G0000002 0797 0938
9761
H- Cald1 CS muscle IPI007760 Q8VD79_ Q8VD79 0.42371 0.00 5 0 0 242.576 0 0 0 0 0 0 0
caldesmon 94.1 MOUSE 0797 7628
Troponin I, Tnni1 CS muscle IPI009181 TNNI1_M D3YUN3 ENSMUS 21952 0.42371 1000.00 4 0 0 0 0 0 0 82.9738 0 0 0
slow 92.1 OUSE G0000002 0797 6498
skeletal 6418
muscle
Myosin-15 Myh15 CS muscle IPI009475 E9Q264_ E9Q264 ENSMUS 667772 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 103.979
79.1 MOUSE G0000009 0797 0405
2009
N-alpha- Naa35 MOD muscle IPI009885 NAA35_ F6UFC8/ ENSMUS 78689 0.42371 0.87 2 0 0 42.4342 0 0 0 36.8990 0 0 0
acetyltransf 51.1/IPI00 MOUSE F7A8R0 G0000002 0797 6042 5488
erase 35, 991073.1 1555
NatC
auxiliary
subunit
Myosin- Mybpc3 CS muscle IPI009890 MYPC3_ E9Q9T8 ENSMUS 0.42371 0.00 1 0 0 22.3101 0 0 0 0 0 0 0
binding 45.2 MOUSE G0000000 0797 6273
protein C, 2100
cardiac-
type
Troponin T, Tnnt1 CS muscle IPI009898 TNNT1_ E9QA86 ENSMUS 21955 0.42371 1000.00 1 0 0 0 0 0 0 28.9391 0 0 0
slow 82.1 MOUSE G0000006 0797 1258
skeletal 4179
muscle
Zinc finger Zfhx4 TF muscle IPI010085 ZFHX4_ Q8C4P4 0.42371 1000.00 1 0 0 0 0 0 60.0652 0 0 0 0
homeobox 32.1 MOUSE 0797 6324
protein 4
VSAG 913002 TM POTEN IPI004583 O70313_ O70316 0.42371 1000.00 1 0 0 0 0 0 0 0 92.8660 0 0
protein 0O15Ri TIALL 09.2 MOUSE 0797 3437
k Y
(RETR
O-
)VIRAL
PROTE
IN
Collagen Col4a1 CS secreted IPI001095 CO4A1_ P02463 ENSMUS 12826 0.42371 1000.00 3 0 0 0 0 0 0 0 490.835 0 0
alpha-1(IV) 88.4 MOUSE G0000003 0797 4096
chain 1502
Beta-2- B2m MHC secreted IPI001099 B2MG_M P01887 0.42371 0.00 2 160.481 0 0 0 0 0 0 0 0 0
microglobu 66.1 OUSE 0797 2475
lin
Chemokine Ppbp SIG secreted IPI001112 Q9EQI5_ Q9EQI5 ENSMUS 57349 0.42371 1000.00 1 0 0 0 0 0 26.7838 0 0 0 0
(C-X-C 10.1 MOUSE G0000002 0797 5583
motif) 9372
ligand 7
(Platelet
basic

- 66 -
protein)
Coiled-coil Ccdc70 UK secreted IPI001124 CCD70_ Q9D9B0 ENSMUS 67929 0.42371 1000.00 1 0 0 0 0 0 72.2465 0 0 0 0
domain- 88.1 MOUSE G0000001 0797 2586
containing 7049
protein 70
Mannose- Mbl2 SIG secreted IPI001134 MBL2_M P41317 ENSMUS 17195 0.42371 1000.00 1 0 0 0 0 0 0 18.3923 0 0 0
binding 57.1 OUSE G0000002 0797 6042
protein C 4863
Collagen Col4a6 CS secreted IPI001134 B1AVK5 B1AVK5 ENSMUS 94216 0.42371 0.00 1 0 217.897 0 0 0 0 0 0 0 0
alpha-6(IV) 75.2 _MOUSE G0000003 0797 6394
chain 1273
Extracellula Sod3 ENZ secreted IPI001143 SODE_M O09164 ENSMUS 20657 0.42371 1000.00 1 0 0 0 0 0 0 0 0 36.3889 0
r 19.1 OUSE G0000007 0797 1621
superoxide 2941
dismutase
[Cu-Zn]
Alpha-1- Orm1 ENZ secreted IPI001181 A1AG1_ Q60590 ENSMUS 18405 0.42371 0.00 1 114.477 0 0 0 0 0 0 0 0 0
acid 30.1 MOUSE G0000003 0797 8546
glycoprotei 9196
n1
Dystroglyc Dag1 CS secreted IPI001222 DAG1_M Q62165 ENSMUS 13138 0.42371 1000.00 1 0 0 0 0 0 0 0 21.0185 0 0
an 73.1 OUSE G0000003 0797 2322
9952
Serpin I2 Serpini2 INH secreted IPI001224 SPI2_MO Q9JK88 ENSMUS 67931 0.42371 0.00 1 0 0 0 202.331 0 0 0 0 0 0
05.1 USE G0000003 0797 6429
4139
Tolloid-like Tll1 ENZ secreted IPI001247 TLL1_M Q62381 21892 0.42371 1000.00 2 0 0 0 0 0 0 200.068 0 0 0
protein 1 95.3 OUSE 0797 0199
Compleme C4b SIG secreted IPI001310 CO4B_M P01029 ENSMUS 12268 0.42371 0.00 3 135.123 0 0 0 0 0 0 0 0 0
nt C4-B 91.3 OUSE G0000007 0797 2771
3418
Bile salt- Cel ENZ secreted IPI001322 CEL_MO P05208 ENSMUS 12613 0.42371 0.00 3 0 0 0 513.786 0 0 0 0 0 0
activated 96.1 USE G0000005 0797 6603
lipase 8579|ENS
MUSG00
00002681
8
Dehydroge Dhrs11 ENZ secreted IPI001534 DHR11_ Q3U0B3 ENSMUS 192970 0.42371 1000.00 1 0 0 0 0 0 0 11.0669 0 0 0
nase/reduct 63.3 MOUSE G0000003 0797 354
ase SDR 4449
family
member 11
Chymotryp Cela1 ENZ secreted IPI001719 CELA1_ Q64285 ENSMUS 109901 0.42371 0.00 2 0 0 0 237.349 0 0 0 0 0 0
sin-like 83.4 MOUSE G0000002 0797 1791
elastase 6818|ENS
family MUSG00
member 1 00002303
1
Semaphorin Sema3d DEV secreted IPI002217 SEM3D_ Q8BH34 ENSMUS 108151 0.42371 1000.00 2 0 0 0 0 0 473.826 0 0 0 0
-3D 11.3 MOUSE G0000004 0797 7325
0254
Podocan Podn MOD secreted IPI002229 PODN_M Q7TQ62 ENSMUS 242608 0.42371 1000.00 1 0 0 0 0 0 0 0 104.471 0 0
16.3 OUSE G0000002 0797 8786
8600
Protein Fam180 UK secreted IPI002239 F180A_M Q8BR21 ENSMUS 208164 0.42371 1000.00 1 0 0 0 0 0 0 0 0 302.754 0
FAM180A a 65.1 OUSE G0000004 0797 0493

- 67 -
 7420
Thioredoxi Txn TP secreted IPI002269 THIO_M P10639 ENSMUS 22166 0.42371 0.00 2 0 0 0 0 148.184 0 0 0 0 0
n 93.5 OUSE G0000002 0797 8695
8367
Collagen Col11a1 CS secreted IPI002300 COBA1_ Q61245 ENSMUS 12814 0.42371 0.00 2 0 0 127.478 0 0 0 0 0 0 0
alpha-1(XI) 65.4 MOUSE G0000002 0797 7723
chain 7966
Cartilage Cilp2 SCA secreted IPI002829 D3Z7H8_ D3Z7H8 ENSMUS 68709 0.42371 1000.00 1 0 0 0 0 0 0 0 78.4769 0 0
intermediat 30.6 MOUSE G0000004 0797 4239
e layer 4006
protein 2
Chymotryp Ctrb1 ENZ secreted IPI003156 CTRB1_ Q9CR35 ENSMUS 66473 0.42371 0.00 2 0 0 0 1658.26 0 0 0 0 0 0
sinogen B 96.3 MOUSE G0000003 0797 1883
1957
Serine Prss23 ENZ secreted IPI003180 PRS23_M Q9D6X6 ENSMUS 76453 0.42371 1000.00 2 0 0 0 0 0 0 0 415.552 0 0
protease 23 17.1 OUSE G0000003 0797 5696
9405
Chymotryp Ctrl ENZ secreted IPI003183 Q9ER05_ Q9ER05 ENSMUS 109660 0.42371 0.00 2 0 0 0 559.433 0 0 0 0 0 0
sin-like 76.2 MOUSE G0000003 0797 4771
protease 1896
CTRL-1
Ladinin-1 Lad1 CS secreted IPI003195 LAD1_M P57016 ENSMUS 16763 0.42371 1000.00 1 0 0 0 0 0 0 36.4630 0 0 0
58.1 OUSE G0000004 0797 6319
1782
Laminin Lamb1 CS secreted IPI003387 LAMB1_ B9EKB0 ENSMUS 0.42371 1000.00 2 0 0 0 0 0 0 49.4912 0 0 0
subunit 85.3 MOUSE G0000000 0797 8244
beta-1 2900
Carboxype Cpb1 ENZ secreted IPI003511 B2RS76_ B2RS76 ENSMUS 76703 0.42371 0.00 2 0 0 0 196.519 0 0 0 0 0 0
ptidase B 50.1 MOUSE G0000001 0797 8091
1463
Laminin Lamc1 CS secreted IPI004000 LAMC1_ P02468 0.42371 0.00 3 0 0 124.155 0 0 0 0 0 0 0
subunit 16.1 MOUSE 0797 4701
gamma-1
Pancreatic Pnlip ENZ secreted IPI004204 LIPP_MO Q6P8U6 ENSMUS 69060 0.42371 0.00 2 0 0 0 216.809 0 0 0 0 0 0
triacylglyce 41.1 USE G0000004 0797 7181
rol lipase 6008
Polypeptide Galnt2 ENZ secreted IPI004608 GALT2_ Q6PB93 ENSMUS 108148 0.42371 1000.00 1 0 0 0 0 0 0 55.2433 0 0 0
N- 65.1 MOUSE G0000008 0797 4087
acetylgalact 9704|ENS
osaminyltra MUSG00
nsferase 2 00009232
9
Mucin-19 Muc19 CS secreted IPI004642 MUC19_ Q6PZE0 239611 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 43.0332
59.2 MOUSE 0797 4554
Semaphorin Sema3g DEV secreted IPI006252 SEM3G_ Q4LFA9 ENSMUS 218877 0.42371 1000.00 1 0 0 0 0 0 0 54.6259 0 0 0
-3G 02.3 MOUSE G0000002 0797 4975
1904
Collagen Col4a4 CS secreted IPI006263 CO4A4_ Q9QZR9 ENSMUS 12829 0.42371 0.00 4 0 0 308.657 0 0 0 0 0 0 0
alpha-4(IV) 53.5 MOUSE G0000006 0797 4789
chain 7158
A Adamts ENZ secreted IPI007500 E9PUN6_ E9PUN6 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 29.9547 0 0 0 0
disintegrin 9 18.3 MOUSE G0000003 0797 1556
and 0022
metalloprot
einase with
thrombospo

- 68 -
ndin motifs
9
Aldo-keto Akr1b1 ENZ secreted IPI007506 D3Z494_ D3Z494 ENSMUS 0.42371 1000.00 4 0 0 0 0 0 0 0 0 0 333.979
reductase 0 87.1 MOUSE G0000006 0797 5305
family 1, 1758
member
B10
Tubulointer Tinagl1 ?MOD? secreted IPI007545 TINAL_ Q4FJX7 ENSMUS 94242 0.42371 0.00 1 0 0 21.8695 0 0 0 0 0 0 0
stitial 66.1 MOUSE G0000002 0797 674
nephritis 8776
antigen-like
Pancreatic Amy2 ENZ secreted IPI008812 AMYP_M Q6LDX8/ ENSMUS 10004368 0.42371 0.01 11 0 0 0 6317.47 0 0 0 0 0 85.8207
alpha- 76.2/IPI00 OUSE P00688 G0000007 4 0797 7013 2886
amylase 133544.2 9850|ENS
MUSG00
00007426
6|ENSMU
SG000000
74267|EN
SMUSG0
00000742
68
Inter-alpha- Itih4 INH secreted IPI008817 Q9DBK8 Q9DBK8 ENSMUS 0.42371 0.00 4 0 156.546 0 0 0 0 0 0 0 0
trypsin 01.2 _MOUSE G0000002 0797 1134
inhibitor 1922
heavy chain
H4
Collagen Col12a1 CS secreted IPI008819 COCA1_ Q3TNZ7 ENSMUS 0.42371 1000.00 3 0 0 0 0 0 0 0 298.228 0 0
alpha- 09.1 MOUSE G0000003 0797 7039
1(XII) 2332
chain
Extracellula Ecm1 CS secreted IPI008857 ECM1_M D3Z772 ENSMUS 13601 0.42371 1000.00 1 0 0 0 0 0 0 1127.52 0 0 0
r matrix 01.1 OUSE G0000002 0797 957
protein 1 8108
Clusterin Clu CHA secreted IPI009182 CLUS_M E9PUU2/ ENSMUS 12759 0.42371 0.41 9 165.065 0 0 0 0 0 67.4702 0 0 0
14.1/IPI00 OUSE Q06890 G0000002 0797 7325 3754
320420.3 2037
Matrilin-3 Matn3 CS secreted IPI009706 MATN3_ O35701 ENSMUS 17182 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 80.3441
28.4 MOUSE G0000002 0797 4256
0583
Ceruloplas Cp TP secreted IPI009872 CERU_M Q8BV37/ ENSMUS 12870 0.42371 0.00 4 50.3466 18.4688 0 0 0 0 0 0 0 0
min 03.1/IPI01 OUSE G3UXG1 G0000000 0797 5845 6825
027408.1 3617
Thyroglobu Tg SIG secreted IPI009875 THYG_M F6XYF6/ ENSMUS 21819 0.42371 3.64 2 0 0 40.5528 0 0 0 0 0 0 147.415
lin 47.1/IPI00 OUSE O08710 G0000005 0797 4736 6432
309177.2 3469
Compleme Cfh SIG secreted IPI009879 CFAH_M Q8C5S1 0.42371 0.00 5 144.288 0 0 0 0 0 0 0 0 0
nt factor H 33.1 OUSE 0797 3766
Apolipopro Apoe TP secreted IPI010270 APOE_M G3UWN5 ENSMUS 11816 0.42371 0.00 4 107.565 0 55.1028 0 0 0 0 0 0 0
tein E 81.1/IPI01 OUSE /G3UZM8 G0000000 0797 8064 4207
027003.1 2985
Probable BC0944 ENZ VIRAL IPI004208 Q8C2B1_ Q8C2B1 0.42371 1000.00 1 0 0 0 0 0 755.149 0 0 0 0
Pol 35 14.3 MOUSE 0797 4672
polyprotein
DNA D17H6 CS viral IPI010273 Q91UZ6_ G3UZE5 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 126.038 0
segment, S56E-5 99.1 MOUSE G0000009 0797 4677

- 69 -
Chr 17, 1747
human
D6S56E 5,
isoform
CRA_c
Putative 181001 UK IPI001081 Q9CVM3 Q9CVM3 0.42371 0.00 1 0 19.1030 0 0 0 0 0 0 0 0
uncharacter 3D15Ri 35.1 _MOUSE 0797 4206
ized protein k
1810013D1
5Rik
DNA Gins2 CC IPI001082 PSF2_MO Q9D600 ENSMUS 272551 0.42371 0.00 1 0 0 0 162.757 0 0 0 0 0 0
replication 54.3 USE G0000003 0797 7435
complex 1821
GINS
protein
PSF2
Putative 170008 UK IPI001082 Q9CVQ3 Q9CVQ3 0.42371 1000.00 1 0 0 0 0 0 0 0 36.5451 0 0
uncharacter 4K02Ri 59.6 _MOUSE 0797 5714
ized protein k
1700084K0
2Rik
Putative 170008 UK IPI001082 Q9CVQ8 Q9CVQ8 0.42371 0.00 1 0 0 0 0 80.3174 0 0 0 0 0
uncharacter 0G18Ri 79.4 _MOUSE 0797 2787
ized protein k
1700080G1
8Rik
Serine/thre Ppp3cc ENZ IPI001083 PP2BC_ Q9D5R5 ENSMUS 19057 0.42371 0.00 1 0 659.582 0 0 0 0 0 0 0 0
onine- 18.1 MOUSE G0000002 0797 7887
protein 2092
phosphatas
e 2B
catalytic
subunit
gamma
isoform
Putative 150000 UK IPI001084 Q9CW33 Q9CW33 0.42371 0.00 1 0 0 28.0654 0 0 0 0 0 0 0
uncharacter 9C09Ri 24.3 _MOUSE 0797 7998
ized protein k
1500009C0
9Rik
Uncharacte UK IPI001086 CG031_M Q3TT91 ENSMUS 70821 0.42371 1000.00 1 0 0 0 0 0 527.538 0 0 0 0
rized 51.1 OUSE G0000002 0797 5601
protein 9828
C7orf31
homolog
Tubulin Tubb2b CS IPI001090 TBB2B_ Q9CWF2 ENSMUS 73710 0.42371 0.00 9 0 0 0 0 2306.29 0 0 0 0 0
beta-2B 61.1 MOUSE G0000004 0797 81
chain 5136
UPF0760 D1Bwg UK IPI001093 CB029_M Q9CWN7 ENSMUS 52846 0.42371 0.00 1 0 0 93.8663 0 0 0 0 0 0 0
protein 0212e 13.1 OUSE G0000000 0797 8537
C2orf29 3135
homolog
NTPase Nkpd1 TM IPI001101 NKPD1_ Q0VF94 69547 0.42371 0.00 1 0 59.9839 0 0 0 0 0 0 0 0
KAP 57.7 MOUSE 0797 1823
family P-
loop
domain-

- 70 -
containing
protein 1
TOX high Tox2 TF IPI001102 A2A472_ A2A473 ENSMUS 0.42371 0.00 1 626.282 0 0 0 0 0 0 0 0 0
mobility 46.5 MOUSE G0000007 0797 9214
group box 4607
family
member 2
Receptor- Ptprf RCP IPI001102 PTPRF_ A2A8L5 ENSMUS 19268 0.42371 0.00 1 0 0 0 300.592 0 0 0 0 0 0
type 64.2 MOUSE G0000003 0797 8242
tyrosine- 3295
protein
phosphatas
eF
Ankyrin Ankrd3 UK IPI001103 Q5QNR3 Q5QNR3 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 59.8391 0
repeat 6 01.3 _MOUSE G0000002 0797 9952
domain 36 0481
Calpain-9 Capn9 ENZ IPI001106 CAN9_M Q9D805 ENSMUS 73647 0.42371 0.00 2 0 0 0 0 776.340 0 0 0 0 0
24.4 OUSE G0000003 0797 9323
1981
Dehydroge Dhrs7 ENZ IPI001106 DHRS7_ Q9CXR1 ENSMUS 66375 0.42371 0.00 1 39.1794 0 0 0 0 0 0 0 0 0
nase/reduct 59.2 MOUSE G0000002 0797 3985
ase SDR 1094
family
member 7
2310047B1 231004 UK IPI001107 Q9CXT5_ Q9CXT5 0.42371 0.00 1 0 0 0 0 91.5689 0 0 0 0 0
9Rik 7B19Ri 72.1 MOUSE 0797 7483
k
Transmemb Tmem6 TM IPI001108 TMM68_ Q9D850 ENSMUS 72098 0.42371 0.00 1 0 0 119.986 0 0 0 0 0 0 0
rane protein 8 53.4 MOUSE G0000002 0797 7693
68 8232
B-cell Bcl6 TF IPI001116 BCL6_M P41183 ENSMUS 12053 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 24.4071
lymphoma 06.1 OUSE G0000002 0797 9357
6 protein 2508
homolog
Transmemb Tmem1 UK IPI001120 TM160_ Q9D938 ENSMUS 69094 0.42371 0.00 1 0 0 0 76.5802 0 0 0 0 0 0
rane protein 60 07.1 MOUSE G0000001 0797 9051
160 9158
Putative 170012 UK IPI001122 Q9D996_ Q9D996 76651 0.42371 0.00 2 0 0 0 343.325 0 0 0 0 0 0
uncharacter 2O11Ri 90.1 MOUSE 0797 6924
ized protein k
1700122O1
1Rik
Retinol Rdh14 ENZ IPI001123 RDH14_ Q9ERI6 ENSMUS 105014 0.42371 1000.00 1 0 0 0 0 0 0 0 0 36.5875 0
dehydrogen 77.1 MOUSE G0000002 0797 3628
ase 14 0621
Protein 281002 UK IPI001124 Q9CZB1_ Q9CZB1 ENSMUS 0.42371 0.00 1 0 0 111.019 0 0 0 0 0 0 0
2810025M 5M15Ri 89.2 MOUSE G0000004 0797 9359
15Rik k 9881
Spermatoge Spata9 DEV IPI001130 SPAT9_ Q9D9R3 ENSMUS 75571 0.42371 1000.00 1 0 0 0 0 0 0 21.4550 0 0 0
nesis- 44.2 MOUSE G0000002 0797 2453
associated 1590
protein 9
Ras-related Rab4a TP IPI001131 RAB4A_ P56371 0.42371 0.00 3 0 365.083 0 0 0 0 0 0 0 0
protein 27.7 MOUSE 0797 0861
Rab-4A
Protein Fam217 UK IPI001132 F217A_M Q9D9W6 71864 0.42371 0.00 1 0 0 0 190.012 0 0 0 0 0 0

- 71 -
FAM217A a 12.3 OUSE 0797 8707
Junctophili Jph1 CS IPI001136 JPH1_MO Q9ET80 ENSMUS 57339 0.42371 0.00 1 0 0 0 123.723 0 0 0 0 0 0
n-1 56.1 USE G0000004 0797 6534
2686
Werner Wrn ENZ IPI001138 WRN_M Q3TMV6/ ENSMUS 22427 0.42371 10.14 2 0 18.5074 0 0 0 0 187.709 0 0 0
syndrome 30.5/IPI00 OUSE E9Q2W6 G0000003 0797 8114 6023
ATP- 113872.5 1583
dependent
helicase
homolog
Alpha- Actr1a CS IPI001138 ACTZ_M P61164 ENSMUS 54130 0.42371 0.00 2 0 0 471.313 0 0 0 0 0 0 0
centractin 95.1 OUSE G0000002 0797 7364
5228
Actin, Actc1 CS IPI001145 ACTC_M Q61275 ENSMUS 11464 0.42371 0.00 19 0 0 27519.5 0 0 0 0 0 0 0
alpha 93.1 OUSE G0000006 0797 8631
cardiac 8614
muscle 1
Ras-related Rras SIG IPI001145 RRAS_M P10833 ENSMUS 20130 0.42371 0.00 2 76.1532 0 0 0 0 0 0 0 0 0
protein R- 94.1 OUSE G0000003 0797 7173
Ras 8387
Katanin Katnal1 ENZ IPI001149 KATL1_ Q8K0T4 ENSMUS 231912 0.42371 1000.00 1 0 0 0 0 0 114.634 0 0 0 0
p60 80.7 MOUSE G0000004 0797 9617
ATPase- 1298
containing
subunit A-
like 1
Ectonucleo Entpd2 ENZ IPI001150 ENTP2_ O55026 ENSMUS 12496 0.42371 0.00 2 0 55.4604 23.9737 0 0 0 0 0 0 0
side 89.2/IPI00 MOUSE G0000001 0797 7801 3951
triphosphat 230093.1 5085
e
diphosphoh
ydrolase 2
tRNA Trdmt1 TF IPI001151 TRDMT_ Q8CE27 ENSMUS 13434 0.42371 1000.00 1 0 0 0 0 0 0 45.9974 0 0 0
(cytosine(3 86.1 MOUSE G0000002 0797 9798
8)-C(5))- 6723
methyltrans
ferase
Gamma- Ggt7 ENZ IPI001154 GGT7_M Q99JP7 ENSMUS 207182 0.42371 0.00 1 70.6276 0 0 0 0 0 0 0 0 0
glutamyltra 29.2 OUSE G0000002 0797 8451
nsferase 7 7603
Serine/thre Stk24 ENZ IPI001160 STK24_M Q99KH8 ENSMUS 223255 0.42371 0.00 1 0 0 0 769.359 0 0 0 0 0 0
onine- 65.3 OUSE G0000006 0797 1922
protein 3410
kinase 24
Homeobox Rhox6 TF IPI001164 O70238_ Q8BPD6 ENSMUS 19202 0.42371 0.00 1 0 0 0 465.285 0 0 0 0 0 0
protein 25.2 MOUSE G0000000 0797 319
PSX 6200
Bcl-2- Bcl2a1 SIG IPI001166 B2LA1_ Q07440 ENSMUS 12044 0.42371 1000.00 1 0 0 0 0 0 141.523 0 0 0 0
related 71.1 MOUSE G0000007 0797 2066
protein A1 4147
Choline/eth Chkb ENZ IPI001166 CHKB_M O55229 ENSMUS 12651 0.42371 0.00 1 68.3372 0 0 0 0 0 0 0 0 0
anolamine 81.3 OUSE G0000002 0797 884
kinase 2617
Ras-related Rab3d TP IPI001166 RAB3D_ P35276 ENSMUS 19340 0.42371 1000.00 2 0 0 0 0 0 110.576 0 0 0 0
protein 88.1 MOUSE G0000001 0797 8017
Rab-3D 9066

- 72 -
Ras-related Rab20 TP IPI001167 RAB20_ P35295 ENSMUS 19332 0.42371 0.00 1 48.4270 0 0 0 0 0 0 0 0 0
protein 77.1 MOUSE G0000003 0797 7713
Rab-20 1504
Protein Ppm1g ENZ IPI001170 PPM1G_ Q61074 ENSMUS 14208 0.42371 1000.00 1 0 0 0 0 0 0 20.7328 0 0 0
phosphatas 72.1 MOUSE G0000002 0797 635
e 1G 9147
Mitogen- Map3k2 ENZ IPI001170 M3K2_M Q61083 0.42371 1000.00 1 0 0 0 0 0 81.9134 0 0 0 0
activated 88.2 OUSE 0797 1985
protein
kinase
kinase
kinase 2
Fatty-acid Faah ENZ IPI001171 FAAH1_ O08914 ENSMUS 14073 0.42371 1000.00 2 0 0 0 0 0 0 315.926 0 0 0
amide 76.1 MOUSE G0000003 0797 0027
hydrolase 1 4171
Cell death Cidea SIG IPI001172 CIDEA_ O70302 0.42371 0.00 1 0 107.152 0 0 0 0 0 0 0 0
activator 25.3 MOUSE 0797 4715
CIDE-A
ELKS/Rab Erc1 TP IPI001177 RB6I2_M Q99MI1 ENSMUS 111173 0.42371 1000.00 4 0 0 0 0 0 326.392 0 0 263.228 0
6- 33.1/IPI00 OUSE G0000003 0797 5087 4198
interacting/ 226953.1 0172
CAST
family
member 1
E3 Siah2 CC IPI001177 SIAH2_M Q06986 ENSMUS 20439 0.42371 1000.00 1 0 0 0 0 0 0 93.7906 0 0 0
ubiquitin- 95.2 OUSE G0000003 0797 2249
protein 6432
ligase
SIAH2
Tyrosine- Ptpn18 ENZ IPI001178 PTN18_M Q61152 ENSMUS 19253 0.42371 1000.00 1 0 0 0 0 0 49.9213 0 0 0 0
protein 61.3 OUSE G0000002 0797 3275
phosphatas 6126
e non-
receptor
type 18
Melatonin Mtnr1a RCP IPI001179 MTR1A_ Q61184 ENSMUS 17773 0.42371 0.00 2 0 0 228.493 0 0 0 0 0 0 0
receptor 37.1 MOUSE G0000005 0797 4546
type 1A 4764
Uncharacte UK IPI001179 CA182_M Q9DA44 ENSMUS 76927 0.42371 0.00 1 63.6435 0 0 0 0 0 0 0 0 0
rized 45.1 OUSE G0000001 0797 898
protein 0538
C1orf182
homolog
Uncharacte UK IPI001180 CO039_M E9Q6H2 ENSMUS 74211 0.42371 0.00 1 49.4002 0 0 0 0 0 0 0 0 0
rized 82.2 OUSE G0000003 0797 2977
protein 2300
C15orf39
homolog
Vomeronas Vmn2r1 RCP IPI001181 V2R1_M O70410 56544 0.42371 0.00 1 0 0 0 0 107.446 0 0 0 0 0
al type-2 38.1 OUSE 0797 6581
receptor 1
3-oxo-5- Srd5a2 ENZ IPI001182 S5A2_M Q99NA0 ENSMUS 94224 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 62.7173
alpha- 39.1 OUSE G0000003 0797 1596
steroid 4- 8541
dehydrogen
ase 2

- 73 -
Thyroid Tpo ENZ IPI001183 PERT_M P35419 ENSMUS 22018 0.42371 1000.00 1 0 0 0 0 0 0 0 0 208.060 0
peroxidase 12.1 OUSE G0000002 0797 5773
0673
Thrombosp Thbs1 CS IPI001184 TSP1_M P35441 0.42371 0.00 2 123.369 0 0 0 0 0 0 0 0 0
ondin-1 13.2 OUSE 0797 6868
Proteasome Psmb6 ENZ IPI001192 PSB6_M Q60692 ENSMUS 19175 0.42371 0.00 3 108.926 0 0 0 0 0 0 0 0 0
subunit 39.2 OUSE G0000001 0797 4691
beta type-6 8286
Fructose- Aldoc ENZ IPI001194 ALDOC_ P05063 ENSMUS 11676 0.42371 0.00 2 0 375.542 0 0 0 0 0 0 0 0
bisphosphat 58.7 MOUSE G0000001 0797 1386
e aldolase 7390
C
Calnexin Canx CHA IPI001196 CALX_M P35564 ENSMUS 12330 0.42371 0.00 1 0 0 0 0 36.5430 0 0 0 0 0
18.1 OUSE G0000002 0797 8235
0368
Elongation Eef1a2 TF IPI001196 EF1A2_M P62631 ENSMUS 13628 0.42371 1000.00 5 0 0 0 0 0 0 0 0 0 1794.24
factor 1- 67.1 OUSE G0000001 0797 2365
alpha 2 6349
Carboxy- Ctdsp1 ENZ IPI001197 CTDS1_ P58466 ENSMUS 227292 0.42371 1000.00 1 0 0 0 0 0 0 0 0 76.2664 0
terminal 25.1 MOUSE G0000002 0797 1674
domain 6176
RNA
polymerase
II
polypeptide
A small
phosphatas
e1
Ephrin Epha1 RCP IPI001202 EPHA1_ Q60750 ENSMUS 13835 0.42371 1000.00 1 0 0 0 0 0 0 30.4439 0 0 0
type-A 22.2 MOUSE G0000002 0797 1381
receptor 1 9859
Structural Smc1b CC IPI001204 SMC1B_ Q920F6 ENSMUS 140557 0.42371 0.00 2 154.480 0 0 0 0 0 0 0 0 0
maintenanc 90.1 MOUSE G0000002 0797 9067
e of 2432
chromosom
es protein
1B
Guanine Gnb1 MOD IPI001207 GBB1_M P62874 ENSMUS 14688 0.42371 0.00 2 0 0 0 0 192.884 0 0 0 0 0
nucleotide- 16.3 OUSE G0000002 0797 172
binding 9064
protein
G(I)/G(S)/
G(T)
subunit
beta-1
Mimecan Ogn CS IPI001208 MIME_M Q62000 ENSMUS 18295 0.42371 0.00 4 0 0 0 0 714.827 0 0 0 0 0
48.1 OUSE G0000002 0797 352
1390
Leiomodin- Lmod2 CS IPI001212 LMOD2_ Q3UHZ5 ENSMUS 93677 0.42371 1000.00 1 0 0 0 0 0 0 18.4558 0 0 0
2 00.4 MOUSE G0000002 0797 8752
9683
WW Wbp5 UK IPI001212 WBP5_M Q9DD24 ENSMUS 22381 0.42371 1000.00 1 0 0 0 0 0 0 0 0 90.8983 0
domain- 78.1 OUSE G0000004 0797 8414
binding 2712
protein 5
Cysteine- Crip2 DEV IPI001213 CRIP2_M Q9DCT8 ENSMUS 68337 0.42371 0.00 1 0 0 0 0 83.6959 0 0 0 0 0

- 74 -
rich protein 19.1 OUSE G0000000 0797 7591
2 6356
Segment Dvl2 SIG IPI001213 DVL2_M Q60838 ENSMUS 13543 0.42371 0.00 1 100.495 0 0 0 0 0 0 0 0 0
polarity 86.2 OUSE G0000002 0797 017
protein 0888
dishevelled
homolog
DVL-2
Stress- Stip1 SCA IPI001215 STIP1_M Q60864 ENSMUS 20867 0.42371 0.00 2 0 69.6531 0 0 0 0 0 0 0 0
induced- 14.3 OUSE G0000002 0797 9516
phosphopro 4966
tein 1
Class E Bhlhe41 TF IPI001216 BHE41_ Q99PV5 ENSMUS 79362 0.42371 0.00 2 0 0 244.598 0 0 0 0 0 0 0
basic helix- 02.1 MOUSE G0000003 0797 0369
loop-helix 0256
protein 41
Dynein Dynll1 TP IPI001216 DYL1_M P63168 ENSMUS 56455 0.42371 0.00 1 0 0 92.2991 0 0 0 0 0 0 0
light chain 23.1 OUSE G0000000 0797 8447
1, 9013
cytoplasmic
Toll-like Tlr8 RCP IPI001221 TLR8_M P58682 ENSMUS 170744 0.42371 1000.00 1 0 0 0 0 0 171.163 0 0 0 0
receptor 8 84.2 OUSE G0000004 0797 9328
0522
85 kDa Pla2g6 ENZ IPI001223 PA2G6_ P97819 ENSMUS 53357 0.42371 1000.00 1 0 0 0 0 0 0 31.7011 0 0 0
calcium- 27.1 MOUSE G0000004 0797 3965
independen 2632
t
phospholip
ase A2
SCL- Stil DEV IPI001227 STIL_MO Q60988 20460 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 401.840
interrupting 69.3 USE 0797 8833
locus
protein
homolog
Exocyst Exoc6 TP IPI001228 EXOC6_ Q3U9D6 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 184.150 0 0 0 0
complex 31.5 MOUSE G0000005 0797 5735
component 3799
6
C-1- Mthfd1 ENZ IPI001228 C1TC_M Q922D8 ENSMUS 108156 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 900.466
tetrahydrof 62.5 OUSE G0000002 0797 5555
olate 1048
synthase,
cytoplasmic
Protein Wwc1 SIG IPI001235 KIBRA_ Q5SXA9 ENSMUS 211652 0.42371 1000.00 2 0 0 0 0 0 100.724 0 0 0 0
KIBRA 09.4 MOUSE G0000001 0797 8204
8849
Acyl- Lypla2 ENZ IPI001235 LYPA2_ Q9WTL7 ENSMUS 26394 0.42371 1000.00 1 0 0 0 0 0 0 95.6153 0 0 0
protein 18.1 MOUSE G0000002 0797 7802
thioesterase 8670
2
E3 Rnf138 ENZ IPI001237 RN138_M Q9CQE0 ENSMUS 56515 0.42371 0.00 1 0 0 0 0 239.461 0 0 0 0 0
ubiquitin- 49.2 OUSE G0000002 0797 7236
protein 4317
ligase
RNF138
Lysine- Phf2 ENZ IPI001238 PHF2_M Q9WTU0 ENSMUS 18676 0.42371 1000.00 1 0 0 0 0 0 0 0 96.7569 0 0

- 75 -
specific 68.2 OUSE G0000003 0797 4505
demethylas 8025
e PHF2
Sacsin Sacs CHA IPI001241 SACS_M Q9JLC8 ENSMUS 50720 0.42371 0.00 3 152.415 0 27.6326 0 0 0 0 0 0 0
20.5/IPI00 OUSE G0000004 0797 875 1379
816925.1 8279
Polyadenyl Pabpc1 TF IPI001242 PABP1_ P29341 ENSMUS 18458 0.42371 0.00 1 0 0 0 209.655 0 0 0 0 0 0
ate-binding 87.2 MOUSE G0000002 0797 7142
protein 1 2283
Olfactory Olfr125 RCP IPI001249 A2AUA2 A2AUA2 ENSMUS 258370 0.42371 0.00 1 0 0 0 0 438.504 0 0 0 0 0
receptor 3 97.1 _MOUSE G0000007 0797 8707
1253, 5075
pseudogene
1
Olfactory Olfr186 RCP IPI001252 OL186_M Q8VEX5 ENSMUS 258318 0.42371 1000.00 1 0 0 0 0 0 0 0 0 184.590 0
receptor 87.1 OUSE G0000004 0797 1266
186 7960
Polyamine- Pmf1 CC IPI001253 PMF1_M Q9CPV5 ENSMUS 67037 0.42371 1000.00 1 0 0 0 0 0 0 0 164.587 0 0
modulated 81.3 OUSE G0000002 0797 4385
factor 1 8066
Endothelin- Ecel1 ENZ IPI001256 ECEL1_ Q9JMI0 ENSMUS 13599 0.42371 1000.00 1 0 0 0 0 0 0 92.6649 0 0 0
converting 97.2 MOUSE G0000002 0797 9369
enzyme- 6247
like 1
Cystatin-B Cstb INH IPI001259 CYTB_M Q62426 ENSMUS 13014 0.42371 1000.00 1 0 0 0 0 0 0 0 0 47.5456 0
31.1 OUSE G0000000 0797 0388
5054
Peptidyl- Fkbp3 CHA IPI001260 FKBP3_ Q62446 ENSMUS 30795 0.42371 1000.00 1 0 0 0 0 0 0 18.9427 0 0 0
prolyl cis- 00.1 MOUSE G0000002 0797 4872
trans 0949
isomerase
FKBP3
Ras-related Rab14 TP IPI001260 RAB14_ Q91V41 ENSMUS 68365 0.42371 0.00 2 223.501 0 0 0 0 0 0 0 0 0
protein 42.3 MOUSE G0000002 0797 9549
Rab-14 6878
Synaptic Vat1 ENZ IPI001260 VAT1_M Q62465 ENSMUS 26949 0.42371 0.00 3 0 0 822.223 0 0 0 0 0 0 0
vesicle 72.2 OUSE G0000003 0797 5258
membrane 4993
protein
VAT-1
homolog
Exostosin- Extl3 ENZ IPI001261 EXTL3_ Q9WVL6 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 93.2834
like 3 31.4 MOUSE G0000002 0797 0595
1978
A kinase Akap13 SCA IPI001261 E9Q394_ E9Q394 ENSMUS 75547 0.42371 0.00 1 40.8808 0 0 0 0 0 0 0 0 0
(PRKA) 81.9 MOUSE G0000006 0797 7893
anchor 6406
protein 13
H-2 class I H2-D1 MHC IPI001263 HA14_M P14427 0.42371 1000.00 1 0 0 0 0 0 0 17.7641 0 0 0
histocompa 01.1 OUSE 0797 4112
tibility
antigen, D-
P alpha
chain
Down Dscr3 UK IPI001264 DSCR3_ O35075 ENSMUS 13185 0.42371 0.00 1 408.343 0 0 0 0 0 0 0 0 0
syndrome 99.1 MOUSE G0000002 0797 0034

- 76 -
critical 2898
region
protein 3
homolog
Cytoplasmi Bmx ENZ IPI001265 BMX_M P97504 ENSMUS 12169 0.42371 1000.00 2 0 0 0 0 0 96.6336 0 0 0 0
c tyrosine- 19.3 OUSE G0000003 0797 6283
protein 1377
kinase
BMX
Interferon- Ifi202 TF IPI001267 IFI2_MO Q9R002 ENSMUS 10004406 0.42371 0.00 1 0 0 0 0 112.348 0 0 0 0 0
activable 25.3 USE G0000002 8 0797 5008
protein 202 6535
Serine/thre Taok1 ENZ IPI001268 TAOK1_ Q5F2E8 ENSMUS 216965 0.42371 1000.00 1 0 0 0 0 0 31.3987 0 0 0 0
onine- 60.2 MOUSE G0000001 0797 4652
protein 7291
kinase
TAO1
Protein- Tgm2 ENZ IPI001268 TGM2_M P21981 ENSMUS 21817 0.42371 0.00 5 0 0 0 0 410.904 0 0 0 0 0
glutamine 61.3 OUSE G0000003 0797 0178
gamma- 7820
glutamyltra
nsferase 2
Sodium Scn11a CNL IPI001268 SCNBA_ Q9R053 ENSMUS 24046 0.42371 0.00 2 0 151.183 0 0 0 0 0 0 0 0
channel 98.6 MOUSE G0000003 0797 1416
protein type 4115
11 subunit
alpha
Protein Prkcdbp SIG IPI001269 PRDBP_ Q91VJ2 ENSMUS 109042 0.42371 0.00 1 33.1916 0 0 0 0 0 0 0 0 0
kinase C 39.1 MOUSE G0000003 0797 6935
delta- 7060
binding
protein
MCG67419 Olfr772 RCP IPI001270 Q8VGC5 Q8VGC5 ENSMUS 257666 0.42371 1000.00 1 0 0 0 0 0 0 0 0 184.590 0
(Olfactory 29.1 _MOUSE G0000009 0797 1266
receptor 1414
Olfr772)
Protein Olfr898 RCP IPI001270 E9Q9T9_ E9Q9T9 ENSMUS 258871 0.42371 1000.00 1 0 0 0 0 0 0 137.416 0 0 0
Olfr898 53.2 MOUSE G0000006 0797 5133
(Olfactory 0101
receptor
Olfr898)
Putative Hkdc1 ENZ IPI001274 HKDC1_ Q91W97 ENSMUS 216019 0.42371 0.00 4 0 0 215.203 0 0 0 0 0 0 0
hexokinase 95.3 MOUSE G0000002 0797 9644
HKDC1 0080
Zinc finger Zfp90 TF IPI001275 ZFP90_M Q61967 ENSMUS 22751 0.42371 0.00 1 39.0794 0 0 0 0 0 0 0 0 0
protein 90 75.1 OUSE G0000003 0797 3126
1907
Synaptotag Syt11 TP IPI001278 SYT11_M Q9R0N3 ENSMUS 229521 0.42371 1000.00 1 0 0 0 0 0 48.8499 0 0 0 0
min-11 65.2 OUSE G0000006 0797 0167
8923
Synaptotag Syt7 TP IPI001278 SYT7_M Q9R0N7 ENSMUS 54525 0.42371 1000.00 1 0 0 0 0 0 0 216.926 0 0 0
min-7 71.1 OUSE G0000002 0797 695
4743
Polyphosph Fig4 ENZ IPI001281 FIG4_MO Q91WF7 ENSMUS 103199 0.42371 1000.00 1 0 0 0 0 0 0 0 11.2915 0 0
oinositide 01.1 USE G0000003 0797 9008
phosphatas 8417

- 77 -
e
Adenylate Ak1 ENZ IPI001282 KAD1_M Q9R0Y5 ENSMUS 11636 0.42371 1000.00 1 0 0 0 0 0 30.7232 0 0 0 0
kinase 09.3 OUSE G0000002 0797 5986
isoenzyme 6817
1
Amyotroph Als2cr8 TF IPI001283 AL2S8_M Q8VHI4 ENSMUS 241066 0.42371 1000.00 1 0 0 0 0 0 8.77028 0 0 0 0
ic lateral 38.1 OUSE G0000002 0797 6455
sclerosis 2 6017
chromosom
al region
candidate
gene 8
protein
homolog
Lymphocyt Ly75 RCP IPI001292 LY75_M Q60767 ENSMUS 17076 0.42371 0.00 1 0 0 24.8627 0 0 0 0 0 0 0
e antigen 53.3 OUSE G0000002 0797 4504
75 6980
Protocadher Pcdha1 CS IPI001294 Q91Y21_ Q641K6 ENSMUS 116731 0.42371 0.00 1 0 210.635 0 0 0 0 0 0 0 0
in alpha-1 07.1 MOUSE G0000000 0797 5562
7440
Nuclear Nup160 TP IPI001295 NU160_ Q9Z0W3 ENSMUS 59015 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 501.174
pore 35.1 MOUSE G0000005 0797 1996
complex 1329
protein
Nup160
cGMP- Pde3a ENZ IPI001295 PDE3A_ Q9Z0X4 ENSMUS 54611 0.42371 0.00 1 0 0 0 0 297.371 0 0 0 0 0
inhibited 86.1 MOUSE G0000004 0797 7404
3',5'-cyclic 1741
phosphodie
sterase A
Nuclear Nr5a2 TF IPI001296 NR5A2_ P45448 ENSMUS 26424 0.42371 1000.00 2 0 0 0 0 0 173.205 0 0 0 0
receptor 65.1 MOUSE G0000002 0797 7599
subfamily 5 6398
group A
member 2
Adenomato Apc2 CS IPI001302 APC2_M Q9Z1K7 0.42371 0.00 2 0 204.396 0 0 0 0 0 0 0 0
us 38.5 OUSE 0797 0501
polyposis
coli protein
2
Valine-- Vars TF IPI001303 SYVC_M Q9Z1Q9 ENSMUS 22321 0.42371 0.00 1 0 140.062 0 0 0 0 0 0 0 0
tRNA 53.5 OUSE G0000000 0797 4948
ligase 7029
Protein Themis MOD IPI001306 THMS2_ Q91YX0 ENSMUS 230787 0.42371 0.00 1 95.2424 0 0 0 0 0 0 0 0 0
THEMIS2 2 06.2 MOUSE G0000003 0797 0352
7731
MCG11434 Magea6 UK IPI001306 O89010_ O89010 ENSMUS 17142 0.42371 1000.00 1 0 0 0 0 0 0 0 0 263.738 0
3, Magea6, 09.2 MOUSE G0000006 0797 4636
Melanoma 3728
antigen,
family A, 6
Proteasome Psma7 ENZ IPI001314 PSA7_M Q9Z2U0 ENSMUS 26444 0.42371 0.00 2 83.8012 0 0 0 0 0 0 0 0 0
subunit 06.1 OUSE G0000002 0797 6318
alpha type- 7566
7
Glutamate Gria4 CNL IPI001314 GRIA4_ Q9Z2W8 ENSMUS 14802 0.42371 1000.00 1 0 0 0 0 0 22.1524 0 0 0 0

- 78 -
receptor 4 71.2 MOUSE G0000002 0797 7715
5892
Protein 221001 ENZ IPI001316 Q9CPN9_ Q9D7Y7 ENSMUS 67373 0.42371 0.00 1 0 0 0 273.439 0 0 0 0 0 0
2210010C0 0C04Ri 74.3 MOUSE G0000002 0797 3904
4Rik k 9882
(Cationic
trypsin-3)
Geminin Gmnn TF IPI001317 GEMI_M O88513 ENSMUS 57441 0.42371 0.00 1 0 0 36.2775 0 0 0 0 0 0 0
16.1 OUSE G0000000 0797 8689
6715
Chymotryp Cela3b ENZ IPI001320 CEL3B_ Q9CQ52 ENSMUS 67868 0.42371 0.00 1 0 0 0 94.8701 0 0 0 0 0 0
sin-like 43.3 MOUSE G0000002 0797 5389
elastase 3433
family
member 3B
Structural Smc3 CC IPI001321 SMC3_M Q9CW03 ENSMUS 13006 0.42371 0.00 1 61.7658 0 0 0 0 0 0 0 0 0
maintenanc 22.3 OUSE G0000002 0797 4121
e of 4974
chromosom
es protein 3
Integrin Itgal CS IPI001322 ITAL_M P24063 ENSMUS 0.42371 0.00 1 0 0 0 115.131 0 0 0 0 0 0
alpha-L 86.2 OUSE G0000003 0797 8487
0830
Crooked Crnkl1 TF IPI001323 CRNL1_ P63154 ENSMUS 66877 0.42371 0.00 1 0 168.318 0 0 0 0 0 0 0 0
neck-like 76.3 MOUSE G0000000 0797 848
protein 1 1767
Ras-related Rab5a TP IPI001324 RAB5A_ Q9CQD1 ENSMUS 271457 0.42371 0.00 2 0 233.343 0 0 0 0 0 0 0 0
protein 10.1 MOUSE G0000001 0797 3792
Rab-5A 7831
Annexin Anxa3 INH IPI001327 ANXA3_ O35639 ENSMUS 11745 0.42371 0.00 3 78.7928 0 0 0 0 0 0 0 0 0
A3 22.9 MOUSE G0000002 0797 9305
9484
Chromatin Chaf1b TF IPI001327 CAF1B_ Q9D0N7 ENSMUS 110749 0.42371 0.00 3 0 0 445.377 0 0 0 0 0 0 0
assembly 70.1 MOUSE G0000002 0797 2462
factor 1 2945
subunit B
40S Rps21 RIB IPI001329 RS21_M Q8C1L7 ENSMUS 66481 0.42371 0.00 3 0 0 0 468.182 0 0 0 0 0 0
ribosomal 50.1 OUSE G0000003 0797 8484
protein S21 9001
60S Rpl14 RIB IPI001331 RL14_M Q569Z0 ENSMUS 67115 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 50.1261
ribosomal 85.3 OUSE G0000002 0797 8133
protein L14 5794
Amyloid- Aplp2 MOD IPI001334 APLP2_ Q06335 ENSMUS 11804 0.42371 0.00 2 0 0 0 0 4287.51 0 0 0 0 0
like protein 21.3 MOUSE G0000003 0797 3648
2 1996
Potassium Kcna1 CNL IPI001337 KCNA1_ P16388 ENSMUS 16485 0.42371 1000.00 1 0 0 0 0 0 97.8988 0 0 0 0
voltage- 19.1 MOUSE G0000004 0797 6798
gated 7976
channel
subfamily
A member
1
Potassium/s Hcn2 CNL IPI001339 HCN2_M O88703 ENSMUS 15166 0.42371 1000.00 1 0 0 0 0 0 0 0 271.823 0 0
odium 80.1 OUSE G0000002 0797 5698
hyperpolari 0331
zation-

- 79 -
activated
cyclic
nucleotide-
gated
channel 2
Potassium/s Hcn3 CNL IPI001339 HCN3_M O88705 ENSMUS 15168 0.42371 0.00 2 135.203 0 0 0 0 0 0 0 0 0
odium 81.1 OUSE G0000002 0797 2154
hyperpolari 8051
zation-
activated
cyclic
nucleotide-
gated
channel 3
Baculoviral Birc6 ENZ IPI001340 BIRC6_M O88738 12211 0.42371 1000.00 2 0 0 0 0 0 0 38.7587 0 0 0
IAP repeat- 95.3 OUSE 0797 0498
containing
protein 6
Low Acp1 ENZ IPI001341 PPAC_M Q9D358 ENSMUS 11431 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 92.8074
molecular 35.1 OUSE G0000004 0797 2168
weight 4573
phosphotyr
osine
protein
phosphatas
e
Dipeptidase Dpep1 ENZ IPI001343 DPEP1_ P31428 13479 0.42371 0.00 2 0 0 24.3230 0 0 0 0 0 0 0
1 90.1 MOUSE 0797 7494
RNA- Rbm12 UK IPI001344 R12BA_ Q80YR9 ENSMUS 72397 0.42371 0.00 1 0 0 14.8091 0 0 0 0 0 0 0
binding ba 17.3 MOUSE G0000004 0797 084
protein 6667
12B-A
U6 snRNA- Lsm4 TF IPI001347 LSM4_M Q9QXA5 50783 0.42371 1000.00 1 0 0 0 0 0 0 75.2638 0 0 0
associated 84.6 OUSE 0797 4096
Sm-like
protein
LSm4
Heme- Hebp1 TP IPI001350 HEBP1_ Q9R257 0.42371 0.00 1 0 0 0 0 172.519 0 0 0 0 0
binding 85.4 MOUSE 0797 2303
protein 1
Testis- Tspyl1 UK IPI001352 TSYL1_ O88852 ENSMUS 22110 0.42371 1000.00 1 0 0 0 0 0 0 0 0 105.425 0
specific Y- 78.1 MOUSE G0000004 0797 0577
encoded- 7514
like protein
1
Probable Trub1 TF IPI001352 TRUB1_ Q8C0D0 ENSMUS 72133 0.42371 1000.00 1 0 0 0 0 0 0 0 0 75.9209 0
tRNA 95.2 MOUSE G0000002 0797 7308
pseudouridi 5086
ne synthase
1
Apoptotic Apaf1 SIG IPI001353 APAF_M O88879 ENSMUS 11783 0.42371 1000.00 1 0 0 0 0 0 0 22.7846 0 0 0
protease- 66.2 OUSE G0000001 0797 5909
activating 9979
factor 1
Putative 643062 UK IPI001354 Q9D367_ Q9D367 0.42371 1000.00 1 0 0 0 0 0 0 0 46.0264 0 0
uncharacter 8N08Ri 34.1 MOUSE 0797 1437
ized protein k

- 80 -
6430628N0
8Rik
Peptidyl- Ppib CHA IPI001356 PPIB_MO P24369 ENSMUS 19035 0.42371 0.00 3 0 0 0 412.984 0 0 0 0 0 0
prolyl cis- 86.2 USE G0000003 0797 2857
trans 2383
isomerase
B
Somatostati Sstr3 RCP IPI001357 SSR3_M P30935 ENSMUS 20607 0.42371 1000.00 1 0 0 0 0 0 1361.16 0 0 0 0
n receptor 13.2 OUSE G0000004 0797 5318
type 3 4933
Uncharacte UK IPI001358 CS068_M Q6DI92 ENSMUS 321008 0.42371 0.00 1 0 0 239.112 0 0 0 0 0 0 0
rized 03.2 OUSE G0000007 0797 2478
protein 0814
C19orf68
homolog
GTP- Rem1 CS IPI001361 REM1_M O35929 ENSMUS 19700 0.42371 0.00 1 597.331 0 0 0 0 0 0 0 0 0
binding 40.1 OUSE G0000000 0797 9181
protein 0359
REM 1
Heparan- Hs6st1 ENZ IPI001362 H6ST1_M Q9QYK5 ENSMUS 50785 0.42371 1000.00 1 0 0 0 0 0 27.6656 0 0 0 0
sulfate 6-O- 80.2 OUSE G0000004 0797 525
sulfotransfe 5216
rase 1
Protein Pabpc6 TF IPI001371 Q9D4E6_ Q9D4E6 ENSMUS 67543 0.42371 1000.00 1 0 0 0 0 0 72.4230 0 0 0 0
Pabpc6 45.1 MOUSE G0000004 0797 1536
(Polyadenyl 6173
ate-binding
protein 6)
Putative 493341 UK IPI001371 Q9D4D5_ Q9D4D5 ENSMUS 0.42371 0.00 1 77.2092 0 0 0 0 0 0 0 0 0
uncharacter 4I15Rik 78.1 MOUSE G0000007 0797 5239
ized protein 2983
4933414I15
Rik
Alpha-N- St6galn ENZ IPI001376 SIA7B_M P70277 ENSMUS 20446 0.42371 0.00 1 36.1701 0 0 0 0 0 0 0 0 0
acetylgalact ac2 08.2 OUSE G0000005 0797 2495
osaminide 7286
alpha-2,6-
sialyltransf
erase 2
Ras-related Rac2 SIG IPI001376 RAC2_M Q05144 ENSMUS 19354 0.42371 1000.00 1 0 0 0 0 0 0 0 58.9839 0 0
C3 18.1 OUSE G0000003 0797 5404
botulinum 3220
toxin
substrate 2
Uncharacte UK IPI001376 CO033_M Q9D518 ENSMUS 75823 0.42371 1000.00 1 0 0 0 0 0 0 0 0 106.662 0
rized 60.3 OUSE G0000002 0797 8152
protein 7209
C15orf33
homolog
HD Hddc2 ENZ IPI001376 HDDC2_ Q3SXD3 ENSMUS 69692 0.42371 1000.00 2 0 0 0 0 0 0 1991.70 0 0 0
domain- 94.5 MOUSE G0000000 0797 7838
containing 0295
protein 2
Phosphatid Pebp1 INH IPI001377 PEBP1_M P70296 ENSMUS 23980 0.42371 0.00 1 0 0 0 70.8409 0 0 0 0 0 0
ylethanola 30.7 OUSE G0000003 0797 5644
mine- 2959

- 81 -
binding
protein 1
Retinoblast Rbl1 CC IPI001378 RBL1_M Q64701 ENSMUS 19650 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 159.365
oma-like 64.2 OUSE G0000002 0797 5695
protein 1 7641
Putative 290005 UK IPI001378 Q9CUW3 Q9CUW3 0.42371 0.00 1 0 0 0 0 91.1972 0 0 0 0 0
uncharacter 7H02Ri 93.2 _MOUSE 0797 1077
ized protein k
2900057H0
2Rik
Phospholip Plb1 ENZ IPI001380 PLB1_M Q3TTY0 ENSMUS 665270 0.42371 1000.00 2 0 0 0 0 0 0 0 62.2777 0 169.705
ase B1, 46.4/IPI00 OUSE G0000002 0797 1674 3435
membrane- 661343.2 9134
associated
Neuron Nav3 DEV IPI001380 NAV3_M Q80TN7 0.42371 0.00 2 0 0 241.889 0 0 0 0 0 0 0
navigator 3 68.7 OUSE 0797 3532
Adenosine Adk ENZ IPI001380 ADK_MO P55264 ENSMUS 11534 0.42371 0.00 1 11.3940 0 0 0 0 0 0 0 0 0
kinase 84.2 USE G0000003 0797 8898
9197
Ig kappa IGG IPI001381 KV6A4_ P01678 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 119.397
chain V-VI 92.1 MOUSE 0797 8059
region
SAPC 10
G protein- Gprin1 DEV IPI001382 GRIN1_ Q3UNH4 ENSMUS 26913 0.42371 0.00 1 99.1331 0 0 0 0 0 0 0 0 0
regulated 32.4 MOUSE G0000006 0797 0781
inducer of 9227
neurite
outgrowth
1
Polyubiquit Ubb SIG IPI001395 UBB_MO P0CG49 ENSMUS 22187 0.42371 0.00 2 0 0 0 330.362 0 0 0 0 0 0
in-B 18.3 USE G0000001 0797 5857
9505
Uncharacte UK IPI001531 CJ047_M Q8C5R2 ENSMUS 227545 0.42371 1000.00 1 0 0 0 0 0 0 88.3891 0 0 0
rized 08.6 OUSE G0000004 0797 1111
protein 5319
C10orf47
homolog
Charged Chmp7 TP IPI001534 CHMP7_ Q8R1T1 ENSMUS 105513 0.42371 0.00 1 0 0 82.3197 0 0 0 0 0 0 0
multivesicu 45.1 MOUSE G0000003 0797 1188
lar body 4190
protein 7
Speckle Tut1 ENZ IPI001537 STPAP_ Q8R3F9 ENSMUS 70044 0.42371 0.00 1 73.4591 0 0 0 0 0 0 0 0 0
targeted 49.2 MOUSE G0000007 0797 5571
PIP5K1A- 1645
regulated
poly(A)
polymerase
Protein Qil1 UK IPI001537 QIL1_MO Q8R404 ENSMUS 224904 0.42371 0.00 1 23.1336 0 0 0 0 0 0 0 0 0
QIL1 92.1 USE G0000004 0797 8432
9760
RUN and Rufy2 TF IPI001538 RUFY2_ Q8R4C2 ENSMUS 70432 0.42371 0.00 1 0 0 71.9627 0 0 0 0 0 0 0
FYVE 75.4 MOUSE G0000002 0797 4385
domain- 0070
containing
protein 2
5- Oplah ENZ IPI001694 OPLA_M Q3TPB5 ENSMUS 75475 0.42371 0.00 1 0 20.4777 0 0 0 0 0 0 0 0

- 82 -
oxoprolinas 73.1 OUSE G0000002 0797 7055
e 2562
Alpha- Fut10 ENZ IPI001696 FUT10_M Q5F2L2 ENSMUS 171167 0.42371 0.00 2 148.878 0 0 0 0 0 0 0 0 0
(1,3)- 26.1 OUSE G0000004 0797 6005
fucosyltran 6152
sferase 10
Cytoplasmi Dync2li CS IPI001696 DC2L1_ Q8K0T2 ENSMUS 213575 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 784.763
c dynein 2 1 38.1 MOUSE G0000002 0797 4173
light 4253
intermediat
e chain 1
NCK Nckap1l TM IPI001698 Q8K1X4_ Q8K1X4 ENSMUS 105855 0.42371 0.00 1 0 0 59.4982 0 0 0 0 0 0 0
associated 46.3 MOUSE G0000002 0797 4651
protein 1 2488
like
DNA/RNA Kin TF IPI001699 KIN17_M Q8K339 ENSMUS 16588 0.42371 0.00 1 230.581 0 0 0 0 0 0 0 0 0
-binding 84.1 OUSE G0000003 0797 9702
protein 7262
KIN17
ATP- Abca6 TP IPI001701 ABCA6_ Q8K441 ENSMUS 76184 0.42371 0.00 2 83.2354 0 0 0 0 0 0 0 0 0
binding 46.4 MOUSE G0000004 0797 2934
cassette 4749
sub-family
A member
6
MKL/myoc Mkl2 TF IPI001720 MKL2_M Q5DTZ3 ENSMUS 239719 0.42371 1000.00 1 0 0 0 0 0 0 14.0250 0 0 0
ardin-like 27.4 OUSE G0000000 0797 2892
protein 2 9569
PH domain Phlpp1 ENZ IPI001723 PHLP1_ Q8CHE4 ENSMUS 98432 0.42371 1000.00 1 0 0 0 0 0 0 129.407 0 0 0
leucine-rich 10.6 MOUSE G0000004 0797 9076
repeat- 4340
containing
protein
phosphatas
e1
Ankyrin Ankfy1 UK IPI001873 ANFY1_ Q810B6 ENSMUS 11736 0.42371 0.00 1 0 0 0 0 125.236 0 0 0 0 0
repeat and 56.2 MOUSE G0000002 0797 5924
FYVE 0790
domain-
containing
protein 1
Zinc finger Znf629 TF IPI002215 ZN629_M Q6A085 ENSMUS 320683 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 181.088
protein 629 22.3 OUSE G0000004 0797 9885
5639
Delta-like Dll3 DEV IPI002219 DLL3_M O88516 ENSMUS 13389 0.42371 0.00 1 69.7032 0 0 0 0 0 0 0 0 0
protein 3 00.1 OUSE G0000000 0797 4836
3436
Adipocyte Apmap ENZ IPI002219 APMAP_ Q9D7N9 ENSMUS 71881 0.42371 0.00 3 0 175.987 0 0 0 0 0 0 0 0
plasma 98.4 MOUSE G0000003 0797 6739
membrane- 3096
associated
protein
Neuronatin Nnat DEV IPI002221 NNAT_M Q61979 ENSMUS 18111 0.42371 0.00 1 39.9893 0 0 0 0 0 0 0 0 0
01.1 OUSE G0000006 0797 7055
7786
Protogenin Prtg DEV IPI002224 PRTG_M Q2EY15 ENSMUS 235472 0.42371 0.00 1 0 27.6318 0 0 0 0 0 0 0 0

- 83 -
 14.5 OUSE G0000003 0797 2178
6030
Myocyte- Mef2b TF IPI002224 MEF2B_ O55087 0.42371 1000.00 1 0 0 0 0 0 203.101 0 0 0 0
specific 76.1 MOUSE 0797 6637
enhancer
factor 2B
Cytoplasmi Dync2h CS IPI002227 DYHC2_ Q45VK7 ENSMUS 110350 0.42371 1000.00 1 0 0 0 0 0 142.108 0 0 0 0
c dynein 2 1 50.7 MOUSE G0000004 0797 1658
heavy chain 7193
1
Putative Ccdc14 UK IPI002229 Q8BLW1 Q8BLW1 0.42371 1000.00 1 0 0 0 0 0 0 0 0 95.1156 0
uncharacter 1 28.1 _MOUSE 0797 8429
ized protein
Transcripti Tcf15 TF IPI002229 TCF15_M Q60756 ENSMUS 21407 0.42371 0.00 1 0 0 417.745 0 0 0 0 0 0 0
on factor 15 80.4 OUSE G0000006 0797 7457
8079
Novel A83003 UK IPI002233 Q8BNT5_ Q8BNT5 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 171.333 0 0 0
protein 1A19Ri 28.1 MOUSE G0000005 0797 612
k 5010
Mitogen- Mapk9 ENZ IPI002233 MK09_M Q9WTU6 ENSMUS 26420 0.42371 0.00 1 44.1149 0 0 0 0 0 0 0 0 0
activated 39.1 OUSE G0000002 0797 1235
protein 0366
kinase 9
Transferrin Tfr2 RCP IPI002236 TFR2_M Q9JKX3 ENSMUS 50765 0.42371 0.00 1 0 107.661 0 0 0 0 0 0 0 0
receptor 50.1 OUSE G0000002 0797 8999
protein 2 9716
Protein Ssh2 ENZ IPI002238 SSH2_M Q5SW75 ENSMUS 237860 0.42371 1000.00 1 0 0 0 0 0 0 0 0 146.329 0
phosphatas 05.4 OUSE G0000003 0797 9136
e Slingshot 7926
homolog 2
Rab11 Rab11fi CC IPI002239 RFIP4_M Q8BQP8 ENSMUS 268451 0.42371 1000.00 1 0 0 0 0 0 0 40.8475 0 0 0
family- p4 00.1 OUSE G0000001 0797 0685
interacting 7639
protein 4
Putative E3 Sh3rf2 ENZ IPI002239 SH3R2_ Q8BZT2 ENSMUS 269016 0.42371 5.54 2 0 0 13.9126 0 0 77.0785 0 0 0 0
ubiquitin- 67.2/IPI00 MOUSE G0000005 0797 9828 7959
protein 227686.2 7719
ligase
SH3RF2
Aldose Akr1b7 ENZ IPI002241 ALD1_M P21300 ENSMUS 11997 0.42371 1000.00 9 0 0 0 0 0 0 0 0 0 989.572
reductase- 81.7 OUSE G0000005 0797 5743
related 2131
protein 1
Vacuolar Ccz1 TP IPI002245 CCZ1_M Q8C1Y8 ENSMUS 231874 0.42371 1000.00 1 0 0 0 0 0 0 54.1643 0 0 0
fusion 61.1 OUSE G0000002 0797 0592
protein 9617
CCZ1
homolog
MAGE-like Magel2 MOD IPI002245 MAGL2_ Q9QZ04 0.42371 1000.00 1 0 0 0 0 0 0 0 180.580 0 0
protein 2 77.5 MOUSE 0797 3721
Putative 533042 UK IPI002246 Q8C2C1_ Q8C2C1 0.42371 1000.00 1 0 0 0 0 0 94.9137 0 0 0 0
uncharacter 9B09Ri 05.1 MOUSE 0797 6828
ized protein k
5330429B0
9Rik
Transmemb TM IPI002248 CI071_M Q8C353 ENSMUS 226040 0.42371 1000.00 1 0 0 0 0 0 0 42.5389 0 0 0

- 84 -
rane protein 31.1 OUSE G0000004 0797 0825
C9orf71 8572
homolog
Kinesin- Kif9 CS IPI002253 KIF9_MO Q8BU81 ENSMUS 16578 0.42371 1000.00 1 0 0 0 0 0 0 141.769 0 0 0
like protein 03.1 USE G0000003 0797 1109
KIF9 2489
Sodium/hy Slc9a4 TP IPI002254 SL9A4_M Q8BUE1 ENSMUS 110895 0.42371 1000.00 2 0 0 0 0 0 0 163.805 0 0 0
drogen 05.1 OUSE G0000002 0797 7783
exchanger 4 6065
MCG14701 Gm125 UK IPI002255 Q8BUP2_ Q8BUP2 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 264.478 0
9 00 35.1 MOUSE G0000005 0797 0394
6411
Putative Casc1 UK IPI002256 Q8BUT4_ Q8BUT4 0.42371 0.00 1 43.0067 0 0 0 0 0 0 0 0 0
uncharacter 29.1 MOUSE 0797 0901
ized protein
Casc1
Ankyrin Ankrd1 UK IPI002256 E9Q4U3_ E9Q4U3 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 95.1024 0 0 0
repeat 3b 30.1 MOUSE G0000003 0797 0484
domain- 7907
containing
protein 13B
Putative 483340 UK IPI002257 Q8C5A3_ Q8C5A3 0.42371 1000.00 1 0 0 0 0 0 0 151.875 0 0 0
uncharacter 8A19Ri 92.1 MOUSE 0797 5848
ized protein k
4833408A1
9Rik
Ankyrin Ankrd3 DEV IPI002258 AN34B_ Q3UUF8 ENSMUS 218440 0.42371 1000.00 1 0 0 0 0 0 0 0 26.6110 0 0
repeat 4b 74.2 MOUSE G0000004 0797 6167
domain- 5034
containing
protein 34B
D-3- Phgdh ENZ IPI002259 SERA_M Q61753 ENSMUS 236539 0.42371 0.00 4 0 0 0 430.915 0 0 0 0 0 0
phosphogly 61.5 OUSE G0000005 0797 3009
cerate 3398
dehydrogen
ase
Hematologi Hn1l UK IPI002259 HN1L_M Q8BW07 ENSMUS 52009 0.42371 1000.00 1 0 0 0 0 0 70.5156 0 0 0 0
cal and 69.1 OUSE G0000002 0797 6863
neurologica 4165
l expressed
1-like
protein
Rho Arhgef1 MOD IPI002262 ARHGJ_ Q8BWA8 ENSMUS 213649 0.42371 0.00 1 0 0 0 0 189.676 0 0 0 0 0
guanine 9 16.5 MOUSE G0000002 0797 0283
nucleotide 8919
exchange
factor 19
Protein Fam171 TM IPI002264 F171B_M Q14CH0 ENSMUS 241520 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 138.192
FAM171B b 92.3 OUSE G0000004 0797 041
8388
Methyltrans Mettl2 ENZ IPI002266 METL2_ Q8BMK1 ENSMUS 52686 0.42371 1000.00 1 0 0 0 0 0 197.374 0 0 0 0
ferase-like 33.1 MOUSE G0000002 0797 8788
protein 2 0691
Solute Slc35g1 TP IPI002269 S35G1_M Q8BY79 ENSMUS 240660 0.42371 0.00 1 0 0 0 0 290.342 0 0 0 0 0
carrier 45.1 OUSE G0000004 0797 8087
family 35 4026

- 85 -
member G1
Actin Afap1l1 CS IPI002275 AF1L1_M Q8BZI0 ENSMUS 106877 0.42371 0.00 1 154.586 0 0 0 0 0 0 0 0 0
filament- 46.3 OUSE G0000003 0797 9571
associated 3032
protein 1-
like 1
Fatty acid- Fabp7 TP IPI002275 FABP7_ P51880 ENSMUS 12140 0.42371 0.00 2 0 0 0 0 180.685 0 0 0 0 0
binding 85.6 MOUSE G0000001 0797 6969
protein, 9874
brain
Nuclear Nemf TP IPI002276 NEMF_M Q8CCP0 ENSMUS 66244 0.42371 1000.00 2 0 0 0 0 0 0 69.1941 0 0 0
export 69.4 OUSE G0000002 0797 0747
mediator 0982
factor Nemf
O- Sepsecs ENZ IPI002276 SPCS_M Q9CYN2 ENSMUS 211006 0.42371 1000.00 2 0 0 0 0 0 0 977.840 0 0 0
phosphoser 78.5 OUSE G0000003 0797 7045
yl- 5227|ENS
tRNA(Sec) MUSG00
selenium 00002917
transferase 3
Signal Stat3 TF IPI002278 STAT3_ P42227 ENSMUS 20848 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 329.246
transducer 14.1 MOUSE G0000000 0797 073
and 4040
activator of
transcriptio
n3
cAMP- Prkaca ENZ IPI002279 KAPCA_ P05132 ENSMUS 18747 0.42371 0.00 1 35.4536 0 0 0 0 0 0 0 0 0
dependent 00.1 MOUSE G0000000 0797 889
protein 5469
kinase
catalytic
subunit
alpha
Protein 923011 UK IPI002284 Q8CC70_ Q8CC70 ENSMUS 234912 0.42371 0.00 1 0 0 152.043 0 0 0 0 0 0 0
9230110C1 0C19Ri 68.1 MOUSE G0000005 0797 8815
9Rik k 3070
(Uncharact
erized
protein
C11orf70
homolog)
Myotrophin Mtpn MOD IPI002285 MTPN_M P62774 ENSMUS 14489 0.42371 0.00 1 29.6960 0 0 0 0 0 0 0 0 0
83.5 OUSE G0000002 0797 4135
9840
Speedy Spdyb CC IPI002287 SPDYB_ Q8CDE8 ENSMUS 74673 0.42371 1000.00 1 0 0 0 0 0 0 0 49.6248 0 0
protein B 97.1 MOUSE G0000002 0797 2512
9586|ENS
MUSG00
00003929
6
Protein 493241 UK IPI002288 E9Q0G0_ E9Q0G0 ENSMUS 0.42371 0.00 1 65.7649 0 0 0 0 0 0 0 0 0
4932415D1 5D10Ri 22.2 MOUSE G0000004 0797 7375
0Rik k 4581
Putative Gm983 UK IPI002288 Q8CDQ7 Q8CDQ7 0.42371 1000.00 1 0 0 0 0 0 0 45.4489 0 0 0
uncharacter 1 94.1 _MOUSE 0797 4552
ized protein

- 86 -
F- Fbxl13 UK IPI002289 FXL13_M Q8CDU4 ENSMUS 320118 0.42371 0.00 1 0 0 0 0 62.2097 0 0 0 0 0
box/LRR- 39.2 OUSE G0000004 0797 8249
repeat 8520
protein 13
EF-hand Efhb UK IPI002289 EFHB_M Q8CDU5 ENSMUS 211482 0.42371 0.00 1 0 0 133.573 0 0 0 0 0 0 0
domain- 41.2 OUSE G0000002 0797 6134
containing 3931
family
member B
UPF0638 UK IPI002289 CB084_M Q8CDW1 ENSMUS 74855 0.42371 0.00 1 0 0 0 75.0659 0 0 0 0 0 0
protein 57.3 OUSE G0000007 0797 4412
C2orf84 9177
homolog
Peptidylpro Ppwd1 CHA IPI002290 PPWD1_ Q8CEC6 ENSMUS 238831 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 44.8739
lyl 25.2 MOUSE G0000002 0797 1953
isomerase 1713
domain and
WD repeat-
containing
protein 1
3 beta- Hsd3b1 ENZ IPI002290 3BHS1_ Q3UI20 ENSMUS 15492 0.42371 1000.00 3 0 0 0 0 0 0 0 0 0 572.503
hydroxyster 70.9 MOUSE G0000002 0797 7203
oid 7871
dehydrogen
ase/Delta 5-
->4-
isomerase
type 1
Hyaluronan Hapln4 CS IPI002291 HPLN4_ Q80WM4 ENSMUS 330790 0.42371 0.00 1 0 0 0 0 204.701 0 0 0 0 0
and 84.3 MOUSE G0000000 0797 6423
proteoglyca 7594
n link
protein 4
Neural Npdc1 TF IPI002293 NPDC1_ A2AJ21 ENSMUS 18146 0.42371 0.00 1 0 222.195 0 0 0 0 0 0 0 0
proliferatio 32.2 MOUSE G0000001 0797 3452
n 5094
differentiati
on and
control
protein 1
cGMP- Pde5a ENZ IPI002293 PDE5A_ Q8CG03 ENSMUS 242202 0.42371 0.00 1 0 0 0 0 165.786 0 0 0 0 0
specific 55.2 MOUSE G0000005 0797 1909
3',5'-cyclic 3965
phosphodie
sterase
Bromodom Bptf TF IPI002294 A2A655_ E9Q6A7 ENSMUS 0.42371 0.00 1 0 0 0 0 44.6826 0 0 0 0 0
ain PHD 32.8 MOUSE G0000004 0797 2424
finger 0481
transcriptio
n factor
(Nucleoso
me-
remodeling
factor
subunit
BPTF)
Ephexin-1 Ngef MOD IPI002297 NGEF_M Q8CHT1 ENSMUS 53972 0.42371 1000.00 1 0 0 0 0 0 145.372 0 0 0 0

- 87 -
 25.2 OUSE G0000002 0797 4852
6259
Melatonin Mtnr1b RCP IPI002299 MTR1B_ Q8CIQ6 0.42371 1000.00 1 0 0 0 0 0 0 169.956 0 0 0
receptor 00.1 MOUSE 0797 4424
type 1B
TRAF Tank MOD IPI002302 TANK_M P70347 ENSMUS 21353 0.42371 1000.00 2 0 0 0 0 0 0 0 125.138 0 0
family 08.1 OUSE G0000006 0797 4214
member- 4289
associated
NF-kappa-
B activator
Vacuolar Vps16 TP IPI002302 VPS16_M Q920Q4 0.42371 1000.00 1 0 0 0 0 0 28.3798 0 0 0 0
protein 39.4 OUSE 0797 7734
sorting-
associated
protein 16
homolog
Hemoglobi Hbz TP IPI002302 HBAZ_M P06467 ENSMUS 15126 0.42371 1000.00 2 0 0 0 0 0 0 0 9491.03 0 0
n subunit 61.5 OUSE G0000005 0797 4769
zeta 5609
Ephrin Epha4 RCP IPI002303 EPHA4_ Q03137 ENSMUS 13838 0.42371 0.00 1 61.9289 0 0 0 0 0 0 0 0 0
type-A 83.2 MOUSE G0000002 0797 4658
receptor 4 6235
Lamin-B1 Lmnb1 CS IPI002303 LMNB1_ P14733 ENSMUS 16906 0.42371 0.00 2 109.481 0 0 0 0 0 0 0 0 0
94.5 MOUSE G0000002 0797 7477
4590
Tuberin Tsc2 SIG IPI002304 TSC2_M Q61037 0.42371 1000.00 1 0 0 0 0 0 126.386 0 0 0 0
80.1 OUSE 0797 0831
Homer Homer3 SCA IPI002626 HOME3_ Q99JP6 ENSMUS 26558 0.42371 0.00 1 0 0 90.7300 0 0 0 0 0 0 0
protein 16.4 MOUSE G0000000 0797 4247
homolog 3 3573
Protein Wiz Wiz TF IPI002630 WIZ_MO O88286 ENSMUS 22404 0.42371 0.00 1 0 258.767 0 0 0 0 0 0 0 0
16.4 USE G0000002 0797 7939
4050
LIM/homeo Lhx3 TF IPI002635 LHX3_M P50481 ENSMUS 16871 0.42371 1000.00 1 0 0 0 0 0 0 0 76.7331 0 0
box protein 57.4 OUSE G0000002 0797 2756
Lhx3 6934
60S Rpl35 RIB IPI002638 RL35_M Q6ZWV7 ENSMUS 66489 0.42371 0.00 2 0 0 0 135.170 0 0 0 0 0 0
ribosomal 79.4 OUSE G0000006 0797 9658
protein L35 2997|ENS
MUSG00
00007819
3
Vascular Vcam1 CS IPI002647 VCAM1_ P29533 ENSMUS 22329 0.42371 0.00 1 0 136.119 0 0 0 0 0 0 0 0
cell 50.4 MOUSE G0000002 0797 4285
adhesion 7962
protein 1
Protein sel- Sel1l2 TM IPI002648 SE1L2_M Q3V172 ENSMUS 228684 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 139.669
1 homolog 22.7 OUSE G0000007 0797 5529
2 4764
Rho Arhgap MOD IPI002652 RHG33_ Q80YF9 ENSMUS 233071 0.42371 0.00 1 48.2827 0 0 0 0 0 0 0 0 0
GTPase- 33 07.1 MOUSE G0000003 0797 4746
activating 6882
protein 33
CAP-Gly Clip3 TP IPI002654 CLIP3_M B9EHT4 ENSMUS 76686 0.42371 0.00 1 0 0 0 0 108.241 0 0 0 0 0
domain- 07.8 OUSE G0000001 0797 0161

- 88 -
containing 3921
linker
protein 3
Amyloid- Aplp2 INH IPI002666 Q60709_ Q60709 ENSMUS 11804 0.42371 1000.00 1 0 0 0 0 0 0 0 106.673 0 0
like protein 99.1 MOUSE G0000003 0797 1953
2 1996
Potassium- Atp12a TP IPI002681 AT12A_ Q9Z1W8 ENSMUS 192113 0.42371 0.00 2 0 0 0 0 218.528 0 0 0 0 0
transporting 45.5 MOUSE G0000002 0797 2928
ATPase 2229
alpha chain
2
Zinc finger Zswim4 TF IPI002690 ZSWM4_ Q6KAT8 ENSMUS 212168 0.42371 0.00 1 169.788 0 0 0 0 0 0 0 0 0
SWIM 32.4 MOUSE G0000003 0797 0811
domain- 5671
containing
protein 4
Vomeronas Vmn2r8 RCP IPI002719 A6H6F2_ O35199 ENSMUS 0.42371 1000.00 2 0 0 0 0 0 0 172.690 0 0 0
al 2, 9 45.5 MOUSE G0000007 0797 7254
receptor 89 0448
Mitogen- Mapk4 ENZ IPI002737 MK04_M E9Q4X9 ENSMUS 225724 0.42371 0.00 1 0 161.112 0 0 0 0 0 0 0 0
activated 26.2 OUSE G0000002 0797 1272
protein 4558
kinase 4
Mitogen- Map4k5 ENZ IPI002766 M4K5_M Q8BPM2 ENSMUS 399510 0.42371 0.00 1 418.374 0 0 0 0 0 0 0 0 0
activated 46.1 OUSE G0000003 0797 4693
protein 4761
kinase
kinase
kinase
kinase 5
Membrane- Ms4a6c RCP IPI002784 M4A6C_ Q99N08 ENSMUS 73656 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 691.650
spanning 4- 92.1 MOUSE G0000007 0797 7825
domains 9419
subfamily
A member
6C
Amphoterin Amigo2 CS IPI002811 AMGO2_ Q80ZD9 ENSMUS 105827 0.42371 0.00 1 0 0 0 0 743.354 0 0 0 0 0
-induced 19.1 MOUSE G0000004 0797 7194
protein 2 8218
Serologicall Sdccag8 CS IPI002838 SDCG8_ Q80UF4 ENSMUS 76816 0.42371 0.00 1 0 0 95.2490 0 0 0 0 0 0 0
y defined 42.3 MOUSE G0000002 0797 4147
colon 6504
cancer
antigen 8
homolog
Protein Sec24d TP IPI002845 Q6NXL1_ Q8R0M3 ENSMUS 69608 0.42371 0.00 1 0 0 0 669.224 0 0 0 0 0 0
transport 95.8 MOUSE G0000003 0797 8136
protein 9234
Sec24D
Crossover Eme1 ENZ IPI003086 EME1_M Q8BJW7 ENSMUS 268465 0.42371 0.00 1 0 83.4960 0 0 0 0 0 0 0 0
junction 62.3 OUSE G0000003 0797 2568
endonuclea 9055
se EME1
Cation- Igf2r RCP IPI003089 MPRI_M Q07113 ENSMUS 16004 0.42371 0.00 3 0 0 311.725 0 0 0 0 0 0 0
independen 71.1 OUSE G0000002 0797 2277
t mannose- 3830

- 89 -
6-
phosphate
receptor
Protein Patl1 TF IPI003090 PATL1_ Q3TC46 ENSMUS 225929 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 336.538
PAT1 59.7 MOUSE G0000004 0797 2246
homolog 1; 6139
AltName:
Full=PAT1
-like
protein 1;
AltName:
Full=Protei
n PAT1
homolog b;
Short=Pat1
b;
Band 4.1- Epb41l2 CS IPI003094 E41L2_M O70318 13822 0.42371 1000.00 1 0 0 0 0 0 8.30417 0 0 0 0
like protein 81.1 OUSE 0797 9049
2
Coronin-2A Coro2a CS IPI003096 COR2A_ Q8C0P5 ENSMUS 107684 0.42371 1000.00 1 0 0 0 0 0 43.0676 0 0 0 0
23.1 MOUSE G0000002 0797 5162
8337
Leiomodin- Lmod1 CS IPI003114 LMOD1_ Q8BVA4 93689 0.42371 0.00 2 0 0 882.921 0 0 0 0 0 0 0
1 22.5 MOUSE 0797 8994
Son of Sos1 MOD IPI003116 SOS1_M Q62245 ENSMUS 20662 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 849.641
sevenless 11.3 OUSE G0000002 0797 6163
homolog 1 4241
Meiotic Rec8 CC IPI003117 REC8_M Q8C5S7 ENSMUS 56739 0.42371 1000.00 2 0 0 0 0 0 0 0 379.888 0 0
recombinati 44.1 OUSE G0000000 0797 0606
on protein 2324
REC8
homolog
WD repeat- Mios UK IPI003117 MIO_MO Q8BV62 ENSMUS 252875 0.42371 1000.00 1 0 0 0 0 0 0 0 1744.34 0 0
containing 85.5 USE G0000004 0797 2265
protein mio 2447
Tyrosine- Btk ENZ IPI003121 BTK_MO Q7TMU1 ENSMUS 12229 0.42371 0.00 1 0 0 0 210.989 0 0 0 0 0 0
protein 16.5 USE G0000003 0797 7351
kinase BTK 1264
Prostagland Ptges2 ENZ IPI003121 PGES2_ Q8BWM0 ENSMUS 96979 0.42371 0.00 1 38.0573 0 0 0 0 0 0 0 0 0
in E 74.7 MOUSE G0000002 0797 2461
synthase 2 6820
Tyrosine-- Yars TF IPI003141 SYYC_M Q91WQ3 ENSMUS 107271 0.42371 0.00 1 0 0 0 0 553.962 0 0 0 0 0
tRNA 53.4 OUSE G0000002 0797 585
ligase, 8811
cytoplasmic
Ligand of Lnx2 SCA IPI003145 LNX2_M Q91XL2 ENSMUS 140887 0.42371 0.00 1 0 0 417.441 0 0 0 0 0 0 0
Numb 65.2 OUSE G0000001 0797 4741
protein X 2 6520
WD repeat- Wdr1 CS IPI003147 WDR1_M Q3U136 ENSMUS 22388 0.42371 0.00 4 154.873 0 0 0 0 0 0 0 0 0
containing 48.7 OUSE G0000000 0797 7859
protein 1 5103
Breast Brca2 CC IPI003149 BRCA2_ P97929 12190 0.42371 1000.00 1 0 0 0 0 0 0 41.3568 0 0 0
cancer type 69.8 MOUSE 0797 1705
2
susceptibilit
y protein

- 90 -
homolog
Semaphorin Sema7a SIG IPI003152 SEM7A_ Q9QUR8 ENSMUS 20361 0.42371 0.00 1 173.409 0 0 0 0 0 0 0 0 0
-7A 80.5 MOUSE G0000003 0797 8976
8264
Bile acid Nr1h4 TF IPI003154 NR1H4_ Q60641 ENSMUS 20186 0.42371 1000.00 1 0 0 0 0 0 0 0 0 131.297 0
receptor 11.3 MOUSE G0000004 0797 7588
7638
Guanine Gnb2l1 SIG IPI003177 GBLP_M P68040 ENSMUS 14694 0.42371 0.00 3 0 0 0 0 203.248 0 0 0 0 0
nucleotide- 40.5 OUSE G0000002 0797 491
binding 0372
protein
subunit
beta-2-like
1
Nucleolin Ncl TF IPI003177 NUCL_M P09405 ENSMUS 17975 0.42371 1000.00 2 0 0 0 0 0 0 0 150.053 0 0
94.5 OUSE G0000002 0797 8103
6234
Kelch-like Klhl35 UK IPI003189 KLH35_ Q9CZ49 ENSMUS 72184 0.42371 0.00 1 0 0 0 30.6433 0 0 0 0 0 0
protein 35 58.6 MOUSE G0000003 0797 8549
5298
Unconventi Myo9b CS IPI003196 MYO9B_ Q9QY06 0.42371 0.00 1 0 0 0 0 85.7660 0 0 0 0 0
onal 97.5 MOUSE 0797 4125
myosin-Ixb
Ketosamine Fn3krp ENZ IPI003219 KT3K_M Q8K274 ENSMUS 238024 0.42371 1000.00 1 0 0 0 0 0 679.313 0 0 0 0
-3-kinase 94.2 OUSE G0000003 0797 313
9253
Ataxin-7 Atxn7 TF IPI003220 ATX7_M Q8R4I1 ENSMUS 246103 0.42371 1000.00 1 0 0 0 0 0 0 103.264 0 0 0
44.2 OUSE G0000002 0797 6764
1738
Thimet Thop1 ENZ IPI003221 THOP1_ Q8C1A5 ENSMUS 50492 0.42371 1000.00 1 0 0 0 0 0 62.9312 0 0 0 0
oligopeptid 50.8 MOUSE G0000000 0797 1853
ase 4929
Acyl-CoA Scd1 ENZ IPI003225 ACOD1_ Q3UXG5 ENSMUS 20249 0.42371 0.00 4 371.247 0 0 0 0 0 0 0 0 0
desaturase 30.1 MOUSE G0000003 0797 1712
1 7071
Amyloid App RCP IPI003230 A4_MOU P12023 ENSMUS 11820 0.42371 0.00 1 0 0 0 2229.56 0 0 0 0 0 0
beta A4 79.1 SE G0000002 0797 6148
protein 2892
Tight Tjp2 CS IPI003233 ZO2_MO Q9Z0U1 ENSMUS 21873 0.42371 0.00 2 418.483 0 0 0 0 0 0 0 0 0
junction 49.2 USE G0000002 0797 8388
protein ZO- 4812
2
Mitogen- Mapk13 ENZ IPI003234 MK13_M Q9Z1B7 ENSMUS 26415 0.42371 0.00 1 0 0 0 300.592 0 0 0 0 0 0
activated 24.1 OUSE G0000000 0797 8242
protein 4864
kinase 13
G2/mitotic- Ccnb3 CC IPI003299 CCNB3_ Q810T2 ENSMUS 0.42371 0.00 2 0 0 232.813 0 0 0 0 0 0 0
specific 21.1 MOUSE G0000005 0797 5058
cyclin-B3 1592
Peroxisome Pprc1 TF IPI003302 PPRC1_ Q6NZN1 ENSMUS 226169 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 225.686
proliferator 52.3 MOUSE G0000005 0797 4571
-activated 5491
receptor
gamma
coactivator-
related

- 91 -
protein 1
Putative Dnajc6 ENZ IPI003302 AUXI_M Q80TZ3 ENSMUS 72685 0.42371 1000.00 1 0 0 0 0 0 82.6596 0 0 0 0
tyrosine- 69.3 OUSE G0000002 0797 6089
protein 8528
phosphatas
e auxilin
Novel zinc Zfp867 TF IPI003303 Q5SXJ1_ Q80UU4 0.42371 1000.00 1 0 0 0 0 0 0 325.114 0 0 0
finger 68.4 MOUSE 0797 69
domain-
containing
protein,
Protein
Zfp867
Protein Ppm1d ENZ IPI003306 PPM1D_ Q9QZ67 ENSMUS 53892 0.42371 1000.00 1 0 0 0 0 0 0 0 63.6519 0 0
phosphatas 66.3 MOUSE G0000002 0797 417
e 1D 0525
Protein Samd4b UK IPI003307 SMAG2_ Q80XS6 0.42371 1000.00 2 0 0 0 0 0 250.359 0 0 0 0
Smaug 80.1 MOUSE 0797 5437
homolog 2
Ezrin Ezr CS IPI003308 EZRI_M P26040 ENSMUS 22350 0.42371 1000.00 4 0 0 0 0 0 0 0 0 212.991 0
62.5 OUSE G0000005 0797 4909
2397
Copper- Atp7a ENZ IPI003310 ATP7A_ Q64430 ENSMUS 11977 0.42371 1000.00 1 0 0 0 0 0 89.1637 0 0 0 0
transporting 44.10 MOUSE G0000003 0797 6039
ATPase 1 3792
E3 Lnx1 TF IPI003310 LNX1_M O70263 ENSMUS 16924 0.42371 1000.00 2 0 0 0 0 0 0 288.626 0 0 0
ubiquitin- 50.2 OUSE G0000002 0797 617
protein 9228
ligase LNX
SAP30- Sap30b TF IPI003311 S30BP_M Q02614 ENSMUS 57230 0.42371 1000.00 1 0 0 0 0 0 0 23.4063 0 0 0
binding p 67.3 OUSE G0000002 0797 6006
protein 0755
HMG box Bbx TF IPI003312 BBX_MO E9PXP0 ENSMUS 70508 0.42371 0.00 1 14.5284 0 0 0 0 0 0 0 0 0
transcriptio 49.7 USE G0000002 0797 1543
n factor 2641
BBX
Importin-7 Ipo7 TP IPI003314 IPO7_MO Q9EPL8 ENSMUS 233726 0.42371 0.00 1 0 273.297 0 0 0 0 0 0 0 0
44.7 USE G0000006 0797 5471
6232
Dapper Dact2 SIG IPI003314 DACT2_ Q7TN08 ENSMUS 240025 0.42371 1000.00 1 0 0 0 0 0 0 0 0 84.9332 0
homolog 2 69.2 MOUSE G0000004 0797 5452
8826
Zinc finger Znf496 TF IPI003314 ZN496_M Q5SXI5 ENSMUS 268417 0.42371 1000.00 1 0 0 0 0 0 0 41.0857 0 0 0
protein 496 98.2 OUSE G0000002 0797 666
0472
Heat shock Hspa4 CHA IPI003315 HSP74_M Q61316 0.42371 0.00 1 29.3475 0 0 0 0 0 0 0 0 0
70 kDa 56.5 OUSE 0797 8182
protein 4
Histone Hist1h1 TF IPI003315 H13_MO P43277 ENSMUS 14957 0.42371 0.00 8 1349.56 0 0 0 0 0 0 0 0 0
H1.3 d 97.6 USE G0000005 0797 3371
2565
Aldehyde Aldh1a ENZ IPI003363 AL1A7_ O35945 ENSMUS 26358 0.42371 0.00 3 182.580 0 0 0 0 0 0 0 0 0
dehydrogen 7 62.2 MOUSE G0000002 0797 0587
ase, 4747
cytosolic 1
Tripartite Trim29 UK IPI003369 TRI29_M Q8R2Q0 ENSMUS 72169 0.42371 0.00 1 0 0 70.8954 0 0 0 0 0 0 0

- 92 -
motif- 13.1 OUSE G0000003 0797 7473
containing 2013
protein 29
Synaptotag Sytl3 TP IPI003370 SYTL3_ Q99N48 ENSMUS 83672 0.42371 1000.00 1 0 0 0 0 0 90.7207 0 0 0 0
min-like 73.2 MOUSE G0000004 0797 5598
protein 3 1831|ENS
MUSG00
00007973
0
Sorting Snx19 TP IPI003379 Q80U53_ Q3TQ83 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 121.057 0 0
nexin-19 29.2 MOUSE G0000003 0797 5518
1993
DNA Pole ENZ IPI003382 DPOE1_ Q9WVF7 ENSMUS 18973 0.42371 0.00 1 0 0 0 275.877 0 0 0 0 0 0
polymerase 95.5 MOUSE G0000000 0797 3189
epsilon 7080
catalytic
subunit A
Probable Atp10a ENZ IPI003386 AT10A_ O54827 ENSMUS 11982 0.42371 1000.00 1 0 0 0 0 0 78.7305 0 0 0 0
phospholipi 18.5 MOUSE G0000002 0797 4481
d- 5324
transporting
ATPase
VA
FERM Frmd6 UK IPI003386 FRMD6_ Q8C0V9 ENSMUS 319710 0.42371 0.00 1 117.089 0 0 0 0 0 0 0 0 0
domain- 37.1 MOUSE G0000004 0797 7047
containing 8285
protein 6
Guanine Gnai3 SIG IPI003388 GNAI3_ Q9DC51 ENSMUS 14679 0.42371 0.00 3 0 0 298.647 0 0 0 0 0 0 0
nucleotide- 54.3 MOUSE G0000000 0797 4477
binding 0001
protein
G(k)
subunit
alpha
Glutathione Gstm3 ENZ IPI003388 GSTM4_ P19639 ENSMUS 14864 0.42371 0.00 3 0 0 443.600 0 0 0 0 0 0 0
S- 55.3 MOUSE G0000000 0797 3083
transferase 4038
Mu 3
60S Rpl12- RIB IPI003394 D3YX33_ D3YX33 ENSMUS 0.42371 0.00 1 0 0 0 161.091 0 0 0 0 0 0
ribosomal ps1 74.3 MOUSE G0000008 0797 3377
protein L12 0054
Tripartite Trim75 TF IPI003399 TRI75_M B2RTB3 ENSMUS 333307 0.42371 0.00 1 0 0 45.3649 0 0 0 0 0 0 0
motif- 60.1 OUSE G0000007 0797 8841
containing 1089
protein 75
TRAF3- Traf3ip SIG IPI003408 MIPT3_M Q149C2 ENSMUS 74019 0.42371 1000.00 1 0 0 0 0 0 0 0 0 60.3898 0
interacting 1 06.8 OUSE G0000003 0797 2436
protein 1 4292
Protocadher Fat2 CS IPI003432 FAT2_M Q5F226 ENSMUS 245827 0.42371 0.00 2 147.690 0 0 0 0 0 0 0 0 0
in Fat 2 14.5 OUSE G0000005 0797 9001
5333
RNA Rnmtl1 ENZ IPI003440 RMTL1_ Q5ND52 ENSMUS 67390 0.42371 0.00 2 342.852 0 0 0 0 0 0 0 0 0
methyltrans 90.7 MOUSE G0000003 0797 67
ferase-like 8046
protein 1
G-protein Gprasp2 MOD IPI003455 GASP2_ Q8BUY8 ENSMUS 245607 0.42371 1000.00 1 0 0 0 0 0 0 0 0 150.592 0

- 93 -
coupled 01.1 MOUSE G0000007 0797 1865
receptor- 2966
associated
sorting
protein 2
U3 small Utp14b DEV IPI003456 UT14B_ E9Q9S3 ENSMUS 195434 0.42371 0.00 1 0 94.6433 0 0 0 0 0 0 0 0
nucleolar 17.2 MOUSE G0000007 0797 8058
RNA- 9470
associated
protein 14
homolog B
PWWP Pwwp2 UK IPI003462 Q3TYY8_ Q3TYY8 ENSMUS 101631 0.42371 0.00 1 0 0 0 676.010 0 0 0 0 0 0
domain- b 83.6 MOUSE G0000006 0797 7211
containing 0260
protein 2B
Protein Fam83b UK IPI003523 FA83B_ Q0VBM2 ENSMUS 208994 0.42371 0.00 3 0 0 261.250 0 0 0 0 0 0 0
FAM83B 94.3 MOUSE G0000003 0797 2856
2358
Tripartite Trim58 TF IPI003536 TRI58_M B9EK29 ENSMUS 216781 0.42371 0.00 1 194.281 0 0 0 0 0 0 0 0 0
motif- 47.3 OUSE G0000003 0797 423
containing 7124
protein 58
Sorting Snx25 TP IPI003539 SNX25_ Q7TQF4 ENSMUS 102141 0.42371 0.00 2 0 114.463 0 0 0 0 0 0 0 0
nexin-25 95.7 MOUSE G0000003 0797 5923
8291
RelA- Ppp1r13 TF IPI003550 IASPP_M Q5I1X5 ENSMUS 333654 0.42371 1000.00 1 0 0 0 0 0 0 14.8155 0 0 0
associated l 42.3 OUSE G0000004 0797 5251
inhibitor 0734
Novel E03002 UK IPI003555 A2A6V5_ A2A6V5 ENSMUS 0.42371 0.00 1 0 0 0 144.531 0 0 0 0 0 0
protein 5P04Ri 04.1 MOUSE G0000007 0797 177
k 8605
Carboxype Cpa1 ENZ IPI003564 CBPA1_ Q7TPZ8 ENSMUS 109697 0.42371 0.00 7 0 0 0 946.670 0 0 0 0 0 0
ptidase A1 48.1 MOUSE G0000005 0797 6296
4446
GRIP and Gcc2 TP IPI003774 GCC2_M Q8CHG3 0.42371 1000.00 1 0 0 0 0 0 17.8358 0 0 0 0
coiled-coil 55.3 OUSE 0797 4511
domain-
containing
protein 2
Zinc finger Znf536 TF IPI003777 ZN536_M Q8K083 ENSMUS 243937 0.42371 1000.00 1 0 0 0 0 0 0 0 29.9286 0 0
protein 536 26.2 OUSE G0000004 0797 7168
3456
Activated Tnk2 ENZ IPI003777 ACK1_M D3Z3U7/ ENSMUS 51789 0.42371 0.00 2 59.5427 19.9207 0 0 0 0 0 0 0 0
CDC42 38.2/IPI00 OUSE O54967 G0000002 0797 6462 5892
kinase 1 856878.3 2791
Novel Btbd19 UK IPI003777 Q3URU3 Q3URU3 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 39.7522 0 0 0
protein 52.3 _MOUSE G0000007 0797 7021
(9530048O 3771
09Rik)
Ras-related Rab6b TP IPI003781 RAB6B_ P61294 ENSMUS 270192 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 314.881
protein 45.1 MOUSE G0000003 0797 4034
Rab-6B 2549
DNA Rev3l ENZ IPI003782 DPOLZ_ Q61493 ENSMUS 19714 0.42371 1000.00 3 0 0 0 0 0 5628.83 0 0 0 0
polymerase 05.3 MOUSE G0000001 0797 7658
zeta 9841
catalytic

- 94 -
subunit
Uncharacte UK IPI003783 CS044_M Q922C1 ENSMUS 72254 0.42371 0.00 1 0 88.4136 0 0 0 0 0 0 0 0
rized 24.3 OUSE G0000005 0797 7769
protein 2794
C19orf44
homolog
LINE-1 L1td1 CC IPI003787 LITD1_M Q587J6 ENSMUS 381591 0.42371 1000.00 1 0 0 0 0 0 0 19.3196 0 0 0
type 00.2 OUSE G0000008 0797 3648
transposase 7166
domain-
containing
protein 1
Claudin-22 Cldn22 CS IPI003798 CLD22_ Q9D7U6 ENSMUS 75677 0.42371 1000.00 1 0 0 0 0 0 35.2318 0 0 0 0
57.2 MOUSE G0000003 0797 8855
8064
Protein Prrc2b UK IPI003804 PRC2B_ Q7TPM1 ENSMUS 227723 0.42371 1000.00 2 0 0 0 0 0 0 122.001 0 0 0
PRRC2B 15.2 MOUSE G0000003 0797 5869
9262
Zinc finger Zc3h14 TF IPI003806 ZC3HE_ Q8BJ05 ENSMUS 75553 0.42371 0.00 1 0 0 0 0 326.546 0 0 0 0 0
CCCH 41.3 MOUSE G0000002 0797 9324
domain- 1012
containing
protein 14
Fibrous Fsip1 CS IPI003807 FSIP1_M Q9D3V5 ENSMUS 71313 0.42371 1000.00 1 0 0 0 0 0 0 0 20.9965 0 0
sheath- 33.2 OUSE G0000002 0797 9056
interacting 7344
protein 1
Melanoma Mageb2 UK IPI003808 Q4U221_ Q60761 ENSMUS 17146 0.42371 1000.00 2 0 0 0 0 0 0 24.1774 0 0 0
antigen, 11.1 MOUSE G0000006 0797 4394
family B, 1 2162
Nck- Nckap5l UK IPI003811 NCK5L_ Q6GQX2 ENSMUS 380969 0.42371 0.00 1 0 0 188.398 0 0 0 0 0 0 0
associated 48.1 MOUSE G0000002 0797 9006
protein 5- 3009
like
Protein Gm116 UK IPI003813 B1AT09_ B1AT09 0.42371 1000.00 1 0 0 0 0 0 0 20.6038 0 0 0
Gm11639 39 83.4 MOUSE 0797 4404
Disintegrin Adam1 ENZ IPI003816 ADA17_ Q9Z0F8 ENSMUS 11491 0.42371 1000.00 1 0 0 0 0 0 0 199.139 0 0 0
and 7 30.5 MOUSE G0000005 0797 6938
metalloprot 2593
einase
domain-
containing
protein 17
Cysteine Atg4b ENZ IPI003871 ATG4B_ Q8BGE6 ENSMUS 66615 0.42371 0.00 1 46.0179 0 0 0 0 0 0 0 0 0
protease 85.2 MOUSE G0000002 0797 6732
ATG4B 6280
Basic Bzw2 DEV IPI003873 BZW2_M Q91VK1 ENSMUS 66912 0.42371 0.00 1 16.8536 0 0 0 0 0 0 0 0 0
leucine 37.1 OUSE G0000002 0797 9185
zipper and 0547
W2
domain-
containing
protein 2
Double- Adar ENZ IPI003952 DSRAD_ Q99MU3 ENSMUS 56417 0.42371 0.00 1 0 45.8224 0 0 0 0 0 0 0 0
stranded 23.1 MOUSE G0000002 0797 1422
RNA- 7951

- 95 -
specific
adenosine
deaminase
DNA repair Rev1 ENZ IPI003967 REV1_M Q920Q2 ENSMUS 56210 0.42371 0.00 1 0 38.3908 0 0 0 0 0 0 0 0
protein 06.1 OUSE G0000002 0797 5591
REV1 6082
TATA box- Tbpl2 TF IPI003967 TBPL2_ B7ZMZ6 ENSMUS 227606 0.42371 0.00 1 0 0 0 271.617 0 0 0 0 0 0
binding 94.4 MOUSE G0000006 0797 5942
protein-like 1809
protein 2
Liprin-beta- Ppfibp2 MOD IPI004000 LIPB2_M O35711 ENSMUS 19024 0.42371 1000.00 1 0 0 0 0 0 0 91.0036 0 0 0
2 18.2 OUSE G0000003 0797 9877
6528
Nexilin Nexn CS IPI004001 NEXN_M Q7TPW1 ENSMUS 68810 0.42371 0.00 1 73.7500 0 0 0 0 0 0 0 0 0
68.3 OUSE G0000003 0797 2591
9103
Putative UK IPI004030 Q8BHV0 Q8BHV0 0.42371 0.00 1 0 0 0 899.741 0 0 0 0 0 0
uncharacter 82.1 _MOUSE 0797 4112
ized protein
Zinc finger Plagl2 TF IPI004034 Q8CFT9_ Q8CFT9 ENSMUS 0.42371 0.00 1 63.1662 0 0 0 0 0 0 0 0 0
protein 03.4 MOUSE G0000005 0797 7873
PLAGL2 1413
Threonine Thnsl2 ENZ IPI004035 THNS2_ Q80W22 ENSMUS 232078 0.42371 1000.00 2 0 0 0 0 0 162.074 0 0 0 0
synthase- 79.3 MOUSE G0000005 0797 9137
like 2 4474
Testis- Tssk1b ENZ IPI004039 TSSK1_ Q61241 ENSMUS 22114 0.42371 1000.00 1 0 0 0 0 0 0 111.205 0 0 0
specific 35.1 MOUSE G0000004 0797 4518
serine/threo 1566
nine-
protein
kinase 1
Erythrocyte Stom MOD IPI004040 STOM_M E9PW33 ENSMUS 13830 0.42371 1000.00 3 0 0 0 0 0 0 56.7860 0 0 0
band 7 17.1 OUSE G0000002 0797 0757
integral 6880
membrane
protein
Leucine- Lrrc8c UK IPI004045 LRC8C_ Q8R502 ENSMUS 100604 0.42371 1000.00 1 0 0 0 0 0 0 56.2732 0 0 0
rich repeat- 95.3 MOUSE G0000005 0797 9318
containing 4720
protein 8C
60S Rpl21- RIB IPI004046 D3Z4H9_ D3Z4H9 ENSMUS 0.42371 0.00 3 57.3237 0 134.559 0 0 0 0 0 0 0
ribosomal ps3 53.4/IPI00 MOUSE G0000006 0797 6947 6623
protein L21 751831.1 0566
Putative BC0184 UK IPI004046 Q8C2L7_ Q8C2L7 0.42371 1000.00 1 0 0 0 0 0 0 0 38.6961 0 0
uncharacter 73 83.2 MOUSE 0797 9594
ized protein
BC018473
Putative Gm762 UK IPI004049 Q8C452_ Q8C452 0.42371 1000.00 1 0 0 0 0 0 0 55.1381 0 0 0
uncharacter 8 54.1 MOUSE 0797 9325
ized protein
Gm7628
Putative Sh3rf3 UK IPI004051 Q8C4U5_ Q8C4U5 0.42371 0.00 1 0 0 64.3432 0 0 0 0 0 0 0
uncharacter 66.1 MOUSE 0797 119
ized protein
Sh3rf3
Protein Gm103 UK IPI004059 Q8C8P7_ Q8C8P7 ENSMUS 0.42371 0.00 1 0 295.022 0 0 0 0 0 0 0 0

- 96 -
Gm10300 00 90.1 MOUSE G0000007 0797 4302
0717
Rho- Rock1 ENZ IPI004064 ROCK1_ P70335 ENSMUS 19877 0.42371 1000.00 2 0 0 0 0 0 0 94.3119 0 0 0
associated 63.2 MOUSE G0000002 0797 8962
protein 4290
kinase 1
Janus Jakmip3 UK IPI004065 JKIP3_M Q5DTN8 ENSMUS 74004 0.42371 1000.00 1 0 0 0 0 0 0 32.0675 0 0 0
kinase and 78.7 OUSE G0000005 0797 0245
microtubule 6856
-interacting
protein 3
B-cell Bcl11b TF IPI004070 BC11B_ Q99PV8 ENSMUS 58208 0.42371 1000.00 1 0 0 0 0 0 0 0 75.0027 0 0
lymphoma/l 13.1 MOUSE G0000004 0797 9732
eukemia 8251
11B
12 kDa IGG IPI004072 D3ZJM5 ENSRNO 0.42371 0.00 1 188.463 0 0 0 0 0 0 0 0 0
protein 73.4 G0000002 0797 82
9800
Lysine- Kdm1b ENZ IPI004073 KDM1B_ Q8CIG3 ENSMUS 218214 0.42371 1000.00 1 0 0 0 0 0 0 33.0309 0 0 0
specific 55.2 MOUSE G0000003 0797 0793
histone 8080
demethylas
e 1B
Chromodo Chd8 TF IPI004075 CHD8_M F7AL76 ENSMUS 67772 0.42371 0.00 1 0 50.4743 0 0 0 0 0 0 0 0
main- 90.6 OUSE G0000005 0797 8333
helicase- 3754
DNA-
binding
protein 8
Arf-GAP Arap1 MOD IPI004076 ARAP1_ Q4LDD4 ENSMUS 69710 0.42371 0.00 1 87.8510 0 0 0 0 0 0 0 0 0
with Rho- 09.2 MOUSE G0000003 0797 0863
GAP 2812
domain,
ANK repeat
and PH
domain-
containing
protein 1
Olfactory Olfr124 RCP IPI004083 A2AT81_ A2AT81 ENSMUS 257984 0.42371 1000.00 1 0 0 0 0 0 195.754 0 0 0 0
receptor 9 25.2 MOUSE G0000007 0797 6918
1249 5079
Down Dscaml CS IPI004084 DSCL1_ Q8R4B4 0.42371 1000.00 5 0 0 0 0 0 0 0 0 0 716.542
syndrome 1 89.1 MOUSE 0797 2591
cell
adhesion
molecule-
like protein
1 homolog
Microtubul Map1a CS IPI004089 MAP1A_ Q9QYR6 ENSMUS 17754 0.42371 0.00 1 0 0 0 106.832 0 0 0 0 0 0
e- 09.4 MOUSE G0000002 0797 8944
associated 7254
protein 1A
Suppressor Sugt1 MOD IPI004089 SUGT1_ Q9CX34 ENSMUS 67955 0.42371 1000.00 1 0 0 0 0 0 0 21.8769 0 0 0
of G2 allele 57.3 MOUSE G0000002 0797 3425
of SKP1 2024
homolog

- 97 -
UPF0505 TM IPI004108 CP062_M D3YW19 ENSMUS 71517 0.42371 1000.00 1 0 0 0 0 0 0 21.3929 0 0 0
protein 44.5 OUSE G0000003 0797 4934
C16orf62 0982
homolog
ATP- Dhx29 ENZ IPI004109 DHX29_ Q6PGC1 ENSMUS 218629 0.42371 0.00 2 5536.14 0 0 0 0 0 0 0 0 0
dependent 36.1 MOUSE G0000004 0797 5254
RNA 2426
helicase
Dhx29
Protein Fam184 UK IPI004109 F184B_M Q0KK56 ENSMUS 58227 0.42371 0.47 4 355.882 0 0 0 0 0 0 0 0 167.474
FAM184B b 84.2/IPI00 OUSE G0000001 0797 6687 5392
885641.1 5879
HEAT Heatr1 TF IPI004110 G3X9B1_ Q3V1X6 ENSMUS 217995 0.42371 0.00 1 0 0 0 2208.15 0 0 0 0 0 0
repeat- 22.1 MOUSE G0000005 0797 7849
containing 0244
protein 1
Insulin Isl1 TF IPI004152 ISL1_MO P61372 ENSMUS 16392 0.42371 1000.00 1 0 0 0 0 0 0 35.3116 0 0 0
gene 62.1 USE G0000004 0797 8878
enhancer 2258
protein
ISL-1
Mediator of Med14 TF IPI004170 MED14_ A2ABV5 ENSMUS 26896 0.42371 1000.00 2 0 0 0 0 0 1851.24 0 0 0 0
RNA 70.2 MOUSE G0000006 0797 7224
polymerase 4127
II
transcriptio
n subunit
14
LIM Limk2 ENZ IPI004171 LIMK2_ O54785 ENSMUS 16886 0.42371 1000.00 1 0 0 0 0 0 66.1162 0 0 0 0
domain 18.1 MOUSE G0000002 0797 0197
kinase 2 0451
General Gtf3c4 TF IPI004171 TF3C4_M Q8BMQ2 ENSMUS 269252 0.42371 1000.00 1 0 0 0 0 0 197.423 0 0 0 0
transcriptio 49.2 OUSE G0000003 0797 8278
n factor 3C 5666
polypeptide
4
Telomerase Smg6 ENZ IPI004171 EST1A_ Q8VCC2 ENSMUS 103677 0.42371 0.00 1 0 0 33.5074 0 0 0 0 0 0 0
-binding 58.1 MOUSE G0000005 0797 2442
protein 7074|ENS
EST1A MUSG00
00003829
0
Solute Slc28a1 TP IPI004204 Q6P8I9_ Q6P8I9 434203 0.42371 0.00 1 0 0 0 159.086 0 0 0 0 0 0
carrier 23.2 MOUSE 0797 032
family 28
(Sodium-
coupled
nucleoside
transporter)
, member 1
Caprin-2 Caprin2 TP IPI004205 CAPR2_ Q0P6A6 ENSMUS 232560 0.42371 1000.00 1 0 0 0 0 0 0 0 0 53.5307 0
12.6 MOUSE G0000003 0797 7048
0309
Ras Rasa4 MOD IPI004208 RASL2_ Q6PFQ7 ENSMUS 54153 0.42371 0.00 2 0 0 424.689 0 0 0 0 0 0 0
GTPase- 68.5 MOUSE G0000000 0797 8882
activating 4952
protein 4

- 98 -
Coiled-coil Ccdc13 DEV IPI004209 CC135_M Q6V3W6 ENSMUS 330830 0.42371 1000.00 1 0 0 0 0 0 0 0 0 650.725 0
domain- 5 88.4 OUSE G0000003 0797 1597
containing 1786
protein
lobo
homolog
Anti- IGG IPI004210 A2NMA3 A2NMA3 0.42371 0.00 3 0 0 1359.75 0 0 0 0 0 0 0
carcinoma 14.8 _MOUSE 0797 9978
embryonic
antigen
light chain
variable
region
Cleavage Cpsf6 TF IPI004210 CPSF6_M Q6NVF9 ENSMUS 432508 0.42371 0.00 1 0 0 181.812 0 0 0 0 0 0 0
and 85.1 OUSE G0000005 0797 9975
polyadenyl 5531
ation
specificity
factor
subunit 6
Sperm- Spag17 CS IPI004212 SPG17_M Q5S003 74362 0.42371 0.00 1 0 19.3366 0 0 0 0 0 0 0 0
associated 40.5 OUSE 0797 7709
antigen 17
acetyl- Acacb ENZ IPI004212 Q6JIZ0_ Q8C697 100705 0.42371 0.00 9 389.550 0 0 0 0 0 0 0 0 0
Coenzyme 41.5 MOUSE 0797 543
A
carboxylase
beta
RING Rnf44 TF IPI004538 RNF44_ Q3UHJ8 ENSMUS 105239 0.42371 1000.00 1 0 0 0 0 0 109.100 0 0 0 0
finger 33.4 MOUSE G0000003 0797 7995
protein 44 4928
Long- Acsbg1 ENZ IPI004538 ACBG1_ Q99PU5 ENSMUS 94180 0.42371 1000.00 1 0 0 0 0 0 322.601 0 0 0 0
chain-fatty- 34.2 MOUSE G0000003 0797 1394
acid--CoA 2281
ligase
ACSBG1
Protocadher Pcdha3 CS IPI004538 Q91Y16_ Q91Y16 192163 0.42371 0.00 1 0 0 0 0 140.708 0 0 0 0 0
in alpha-3 50.2 MOUSE 0797 1822
Protein Efr3a UK IPI004538 EFR3A_ Q8BG67 ENSMUS 76740 0.42371 1000.00 1 0 0 0 0 0 0 0 405.364 0 0
EFR3 63.3 MOUSE G0000001 0797 896
homolog A 5002
Translation Gcn1l1 TF IPI004574 Q3UHQ5 Q6PGM5 231659 0.42371 0.00 3 0 0 0 1121.52 0 0 0 0 0 0
al activator 99.5 _MOUSE 0797 1706
GCN1
Chromodo Chd6 TF IPI004577 A3KFM7 A3KFM7 ENSMUS 71389 0.42371 0.00 2 0 570.859 0 0 0 0 0 0 0 0
main- 24.1 _MOUSE G0000005 0797 1727
helicase- 7133
DNA-
binding
protein 6
Transformi Rhoa MOD IPI004581 RHOA_M Q9QUI0 ENSMUS 11848 0.42371 0.00 2 0 77.8278 0 0 0 0 0 0 0 0
ng protein 09.1 OUSE G0000000 0797 6162
RhoA 7815
MCG12238 170012 UK IPI004581 B2KGE5_ B2KGE5 ENSMUS 68233 0.42371 1000.00 1 0 0 0 0 0 32.4473 0 0 0 0
, isoform 5D06Ri 15.1 MOUSE G0000007 0797 6196
CRA_a, k 8554

- 99 -
1700125D0
6Rik
Hedgehog- Hhip MOD IPI004583 HHIP_M Q7TN16 ENSMUS 15245 0.42371 1000.00 1 0 0 0 0 0 0 71.7909 0 0 0
interacting 26.5 OUSE G0000006 0797 0577
protein 4325
Putative Jagn1 UK IPI004585 Q8BSD0_ Q8BSD0 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 39.7144
uncharacter 28.1 MOUSE 0797 538
ized protein
Jagn1
Cadherin- Cdh13 CS IPI004585 CAD13_ Q8BS79 ENSMUS 12554 0.42371 0.00 1 0 0 25.5271 0 0 0 0 0 0 0
13 74.1 MOUSE G0000003 0797 1919
1841
AP2- Aak1 ENZ IPI004586 AAK1_M Q3UHJ0 ENSMUS 269774 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 93.5714
associated 12.5 OUSE G0000005 0797 3735
protein 7230
kinase 1
KH Khdrbs TF IPI004587 KHDR1_ Q60749 ENSMUS 20218 0.42371 0.00 1 0 295.958 0 0 0 0 0 0 0 0
domain- 1 65.2 MOUSE G0000002 0797 7511
containing, 8790
RNA-
binding,
signal
transductio
n-
associated
protein 1
GTP- Gtpbp8 UK IPI004592 GTPB8_ Q8C5J2 ENSMUS 66067 0.42371 0.00 1 0 0 42.5598 0 0 0 0 0 0 0
binding 83.1 MOUSE G0000002 0797 7454
protein 8 2668
LIM and Lmcd1 TF IPI004593 LMCD1_ Q8BVZ6 ENSMUS 30937 0.42371 0.00 1 0 0 49.5456 0 0 0 0 0 0 0
cysteine- 84.1 MOUSE G0000005 0797 2311
rich 7604
domains
protein 1
NF-kappa- Nkiras2 SIG IPI004594 KBRS2_ Q9CR56 ENSMUS 71966 0.42371 0.00 1 211.609 0 0 0 0 0 0 0 0 0
B inhibitor- 28.2 MOUSE G0000001 0797 9961
interacting 7837
Ras-like
protein 2
Protein BC0241 UK IPI004594 Q8BVJ3_ Q6P556/E ENSMUS 271278 0.42371 0.13 3 0 0 0 3140.84 0 0 396.688 0 0 0
BC024139 39 52.1/IPI00 MOUSE 9Q3A6 G0000004 0797 8947 7153
918026.1 4361
Putative B63001 UK IPI004597 Q8C8L4_ Q8C8L4 0.42371 0.00 1 0 0 116.514 0 0 0 0 0 0 0
uncharacter 9A10Ri 68.1 MOUSE 0797 8137
ized protein k
B630019A
10Rik
Separin Espl1 ENZ IPI004598 ESPL1_M P60330 ENSMUS 105988 0.42371 0.00 2 0 0 108.213 0 0 0 0 0 0 0
98.3 OUSE G0000005 0797 6351
8290
ERC Erc2 CS IPI004605 ERC2_M F8WHE9 ENSMUS 238988 0.42371 1000.00 5 0 0 0 0 0 0 0 0 615.559 0
protein 2 58.4 OUSE G0000004 0797 5697
0640
Protein Bsn CS IPI004611 BSN_MO O88737 ENSMUS 12217 0.42371 0.00 2 0 0 0 388.125 0 0 0 0 0 0
bassoon 99.4 USE G0000003 0797 3579
2589

- 100 -
Protein Cby3 UK IPI004612 CBY3_M Q9CVN6 ENSMUS 0.42371 0.00 1 0 808.007 0 0 0 0 0 0 0 0
chibby 55.3 OUSE G0000005 0797 8228
homolog 3 0087
Putative 493343 UK IPI004613 Q8CDD7 Q8CDD7 0.42371 0.00 1 151.580 0 0 0 0 0 0 0 0 0
uncharacter 3P14Ri 55.1 _MOUSE 0797 366
ized protein k
4933433P1
4Rik
DNA repair Ercc4 ENZ IPI004613 XPF_MO Q9CXC7 ENSMUS 50505 0.42371 0.00 1 16.3441 0 0 0 0 0 0 0 0 0
endonuclea 63.1 USE G0000002 0797 1366
se XPF 2545
Rab GDP Gdi2 MOD IPI004615 GDIB_M Q9CZ18/ ENSMUS 14569 0.42371 1000.00 3 0 0 0 0 0 0 0 103.328 0 106.309
dissociation 80.1/IPI00 OUSE Q61598 G0000002 0797 0618 2157
inhibitor 416577.1 1218
beta
60S Rpl27a RIB IPI004616 RL27A_ E9QP28 ENSMUS 26451 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 50.8978
ribosomal 41.2 MOUSE G0000006 0797 3297
protein 2461|ENS
L27a MUSG00
00005703
6|ENSMU
SG000000
46364
Kelch Gm546 UK IPI004617 Q3TWH9 E9PYD7 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 135.048 0
repeat and 5 10.4 _MOUSE G0000007 0797 6806
BTB 5502
domain-
containing
protein 7
Keratin, Krt77 CS IPI004621 K2C1B_ Q6IFZ6 ENSMUS 406220 0.42371 0.00 2 156.578 0 0 0 0 0 0 0 0 0
type II 40.1 MOUSE G0000006 0797 6528
cytoskeletal 7594
1b
High Hmgb2 TF IPI004622 HMGB2_ P30681 ENSMUS 97165 0.42371 1000.00 2 0 0 0 0 0 236.302 0 0 0 0
mobility 91.5 MOUSE G0000005 0797 5749
group 4717
protein B2
T-box Tbx10 TF IPI004624 TBX10_ Q810F8 ENSMUS 109575 0.42371 0.00 1 0 225.702 0 0 0 0 0 0 0 0
transcriptio 15.1 MOUSE G0000003 0797 0515
n factor 7477
TBX10
F-box and Fbxw20 UK IPI004624 Q5U467_ Q3UXA1 ENSMUS 434440 0.42371 1000.00 1 0 0 0 0 0 0 161.505 0 0 0
WD-40 64.1 MOUSE G0000006 0797 9645
domain 1701
protein 12
Histone- Setd2 TF IPI004624 E9Q5F9_ E9Q5F9 ENSMUS 235626 0.42371 1000.00 3 0 0 0 0 0 162.406 0 0 0 0
lysine N- 66.6 MOUSE G0000004 0797 5011
methyltrans 4791
ferase
SETD2
Igh protein Gm168 IGG IPI004626 Q8K0F2_ Q8K0F2 0.42371 1000.00 3 0 0 0 0 0 0 73.2798 0 0 0
44 38.1 MOUSE 0797 3918
U3 small Utp14a TF IPI004627 UT14A_ Q640M1 ENSMUS 72554 0.42371 0.00 1 321.633 0 0 0 0 0 0 0 0 0
nucleolar 62.2 MOUSE G0000006 0797 8246
RNA- 3785
associated

- 101 -
protein 14
homolog A
A kinase Akap14 SCA IPI004629 Q3V0I7_ Q3V0I7 ENSMUS 434756 0.42371 1000.00 1 0 0 0 0 0 304.810 0 0 0 0
(PRKA) 50.2 MOUSE G0000003 0797 733
anchor 6551
protein 14
Peripheral Nckap5 UK IPI004633 Q29SA9_ F6VHY8 ENSMUS 0.42371 0.00 3 0 0 427.602 0 0 0 0 0 0 0
clock 92.2 MOUSE G0000004 0797 9289
protein 1 9690
(Nck-
associated
protein 5)
Stromal Stim2 TP IPI004641 STIM2_M F6WBP9 ENSMUS 116873 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 109.821
interaction 63.10 OUSE G0000003 0797 5506
molecule 2 9156
Period Per2 TF IPI004658 PER2_M Q8C8R0/ ENSMUS 18627 0.42371 1000.00 2 0 0 0 0 0 0 122.664 0 0 0
circadian 11.2/IPI00 OUSE O54943 G0000005 0797 6492
protein 469179.2 5866
homolog 2
Protein Sdk1 CS IPI004660 SDK1_M Q3UH53 ENSMUS 330222 0.42371 1000.00 2 0 0 0 0 0 298.741 0 0 0 0
sidekick-1 76.4 OUSE G0000003 0797 8416
9683
Zinc finger Znf238 TF IPI004662 ZN238_M Q9WUK6 ENSMUS 30928 0.42371 1000.00 1 0 0 0 0 0 32.2438 0 0 0 0
protein 238 36.2 OUSE G0000006 0797 2321
3659
Transmemb Kiaa092 TM IPI004671 T131L_M Q3U3D7 ENSMUS 229473 0.42371 1000.00 1 0 0 0 0 0 0 0 155.239 0 0
rane protein 2 36.3 OUSE G0000003 0797 0622
131-like 3767
E3 Mib2 ENZ IPI004673 MIB2_M Q8R516 ENSMUS 76580 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 102.386
ubiquitin- 04.3 OUSE G0000002 0797 1586
protein 9060
ligase
MIB2
Cullin-3 Cul3 SCA IPI004673 CUL3_M Q9JLV5 ENSMUS 26554 0.42371 1000.00 2 0 0 0 0 0 0 0 0 185.046 0
83.2 OUSE G0000000 0797 7213
4364
Phosphatid Pik3c2b ENZ IPI004673 E9QAN8_ A2RSK1 ENSMUS 240752 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 112.039
ylinositol 98.4 MOUSE G0000002 0797 8786
4- 6447
phosphate
3-kinase C2
domain-
containing
subunit
beta
ER Edem1 TM IPI004674 EDEM1_ Q925U4 ENSMUS 192193 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 80.2269
degradation 35.2 MOUSE G0000003 0797 2746
-enhancing 0104
alpha-
mannosidas
e-like 1
Calmodulin Calm1 TP IPI004678 CALM_M Q3UKW2 ENSMUS 12313 0.42371 2.06 5 0 364.102 0 0 0 0 0 0 0 750.543
41.6/IPI00 OUSE /P62204 G0000001 0797 9795 8401
761696.2 9370|ENS
MUSG00
00003643

- 102 -
 8|ENSMU
SG000000
01175
Olfactory Olfr103 RCP IPI004691 A2ATE5_ A2ATE5 ENSMUS 258216 0.42371 1000.00 1 0 0 0 0 0 75.2860 0 0 0 0
receptor 4 35.2 MOUSE G0000006 0797 0264
1034 0422
La-related Larp4b TF IPI004692 LAR4B_ Q6A0A2 ENSMUS 217980 0.42371 0.00 1 0 0 0 258.757 0 0 0 0 0 0
protein 4B 35.4 MOUSE G0000003 0797 4827
3499
DNA Dnmt1 TF IPI004693 DNMT1_ Q7TSJ0 ENSMUS 13433 0.42371 1000.00 1 0 0 0 0 0 0 54.0846 0 0 0
(cytosine- 23.3 MOUSE G0000000 0797 3876
5)- 4099
methyltrans
ferase 1
Alpha-2B Adra2b RCP IPI004694 ADA2B_ P30545 0.42371 0.00 2 202.921 0 0 0 0 0 0 0 0 0
adrenergic 42.2 MOUSE 0797 4266
receptor
Interferon Irf2bpl TF IPI004699 I2BPL_M Q8K3X4 ENSMUS 238330 0.42371 1000.00 2 0 0 0 0 0 0 0 0 776.497 0
regulatory 41.2 OUSE G0000003 0797 887
factor 2- 4168
binding
protein-like
Pre- Isy1 TF IPI004699 ISY1_MO Q69ZQ2 ENSMUS 57905 0.42371 1000.00 1 0 0 0 0 0 0 94.3581 0 0 0
mRNA- 94.2 USE G0000003 0797 4031
splicing 0056
factor ISY1
homolog
Ninein Nin CS IPI004710 NIN_MO Q674R4 ENSMUS 18080 0.42371 1000.00 1 0 0 0 0 0 6.77588 0 0 0 0
42.2 USE G0000002 0797 1138
1068
S- Bhmt2 ENZ IPI004712 BHMT2_ Q91WS4 ENSMUS 64918 0.42371 1000.00 1 0 0 0 0 0 0 41.9661 0 0 0
methylmeth 39.2 MOUSE G0000004 0797 5653
ionine-- 2118
homocystei
ne S-
methyltrans
ferase
BHMT2
Cytoplasmi Cyfip1 DEV IPI004733 CYFP1_ Q8C8R2 ENSMUS 20430 0.42371 1000.00 1 0 0 0 0 0 0 116.563 0 0 0
c FMR1- 55.2 MOUSE G0000003 0797 896
interacting 0447
protein 1
Aspartyl/as Asph ENZ IPI004736 Q9D7J8_ Q9D7J8 ENSMUS 65973 0.42371 1000.00 2 0 0 0 0 0 285.115 0 0 0 0
paraginyl 53.1 MOUSE G0000002 0797 3086
beta- 8207
hydroxylas
e
EF-hand Kiaa049 UK IPI004738 K0494_M Q8C192 ENSMUS 0.42371 0.00 1 0 0 0 273.386 0 0 0 0 0 0
domain- 4 83.1 OUSE G0000003 0797 7602
containing 4210
protein
KIAA0494
Putative D83002 UK IPI004739 Q8C6N2_ Q8C6N2 0.42371 0.00 1 0 0 99.4534 0 0 0 0 0 0 0
uncharacter 5C05Ri 16.7 MOUSE 0797 804
ized protein k
D830025C

- 103 -
05Rik
Disintegrin Adam1 ENZ IPI004741 ADA15_ Q9D237 ENSMUS 11490 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 342.123
and 5 17.1 MOUSE G0000002 0797 0428
metalloprot 8041
einase
domain-
containing
protein 15
Putative Rusc1 UK IPI004741 Q9CVB4_ Q9CVB4 0.42371 1000.00 1 0 0 0 0 0 122.177 0 0 0 0
uncharacter 51.1 MOUSE 0797 0004
ized protein
Rusc1
Kctd2 Kctd2 UK IPI004744 Q8JZL6_ Q8JZL6 0.42371 1000.00 1 0 0 0 0 0 0 0 126.180 0 0
protein 09.1 MOUSE 0797 7226
Dystrophin Dmd CS IPI004744 DMD_M P11531 ENSMUS 13405 0.42371 1000.00 1 0 0 0 0 0 59.4325 0 0 0 0
50.2 OUSE G0000004 0797 8651
5103
Phosphoma Pmm2 ENZ IPI004748 PMM2_M Q9CZE9 ENSMUS 54128 0.42371 0.00 1 30.5383 0 0 0 0 0 0 0 0 0
nnomutase 20.1 OUSE G0000002 0797 04
2 2711
Zinc finger Zfhx3 TF IPI004750 ZFHX3_ Q63ZY0 0.42371 0.00 2 0 0 242.165 0 0 0 0 0 0 0
homeobox 55.3 MOUSE 0797 4314
protein 3
Polymerase Polr1d TF IPI004804 Q8R1M3_ Q8R1M3 0.42371 0.00 1 0 0 0 0 276.249 0 0 0 0 0
(RNA) I 94.2 MOUSE 0797 0952
polypeptide
D (DNA-
directed
RNA
polymerase
s I and III
subunit
RPAC2)
Eukaryotic Eif4g1 TF IPI005151 IF4G1_M Q6NZJ6 ENSMUS 208643 0.42371 1000.00 2 0 0 0 0 0 0 0 0 223.523 0
translation 95.2 OUSE G0000004 0797 774
initiation 5983
factor 4
gamma 1
Sodium Scn10a CNL IPI005153 SCNAA_ Q6QIY3 ENSMUS 20264 0.42371 0.00 1 0 0 0 402.120 0 0 0 0 0 0
channel 52.1 MOUSE G0000003 0797 5019
protein type 4533
10 subunit
alpha
Septin-4 Sep-04 CS IPI005513 SEPT4_M P28661 ENSMUS 18952 0.42371 0.00 1 0 91.1187 0 0 0 0 0 0 0 0
70.1 OUSE G0000002 0797 9445
0486
Transcripti E2f8 TF IPI005532 E2F8_MO Q58FA4 ENSMUS 108961 0.42371 0.00 1 152.342 0 0 0 0 0 0 0 0 0
on factor 60.2 USE G0000004 0797 8091
E2F8 6179
Y-box- Ybx2 TF IPI005532 YBOX2_ Q9Z2C8 ENSMUS 53422 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 109.821
binding 86.3 MOUSE G0000001 0797 5506
protein 2 8554
FYVE, Fgd3 MOD IPI005534 FGD3_M O88842 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 382.566
RhoGEF 09.3 OUSE G0000003 0797 5178
and PH 7946
domain-

- 104 -
containing
protein 3
Regulating Rims1 TP IPI005535 RIMS1_ Q99NE5 116837 0.42371 1000.00 2 0 0 0 0 0 0 68.1842 0 0 0
synaptic 49.2 MOUSE 0797 1436
membrane
exocytosis
protein 1
Histone Hist1h2 TF IPI005548 H2B1B_ Q64475 ENSMUS 319178 0.42371 1000.00 6 0 0 0 0 0 0 1252.77 0 0 0
H2B type bb 53.3 MOUSE G0000007 0797 5955
1-B 5031
Aminopepti Aopep ENZ IPI005549 AMPO_M Q8BXQ6 ENSMUS 0.42371 0.00 1 0 0 0 82.8817 0 0 0 0 0 0
dase O 16.1 OUSE G0000002 0797 4816
1458
Chloride Clcn6 TP IPI005549 CLCN6_ Q5DU51 ENSMUS 26372 0.42371 1000.00 1 0 0 0 0 0 231.120 0 0 0 0
transport 17.5 MOUSE G0000002 0797 2544
protein 6 9016
Glutathione Gstt1 ENZ IPI005549 GSTT1_ Q64471 0.42371 1000.00 1 0 0 0 0 0 55.5519 0 0 0 0
S- 33.2 MOUSE 0797 9628
transferase
theta-1
Baculoviral Naip6 MOD IPI005550 BIR1F_M Q14B43 ENSMUS 17952 0.42371 0.00 1 0 0 121.984 0 0 0 0 0 0 0
IAP repeat- 76.3 OUSE G0000007 0797 7755
containing 8942
protein 1f
Importin Kpna7 TP IPI006048 IMA8_M E9PYM6 ENSMUS 381686 0.42371 0.00 1 0 0 89.0609 0 0 0 0 0 0 0
subunit 92.3 OUSE G0000003 0797 0922
alpha-8 8770
SH3 and Shank1 SCA IPI006060 SHAN1_ D3YZU5 ENSMUS 243961 0.42371 1000.00 1 0 0 0 0 0 0 0 70.8006 0 0
multiple 39.3 MOUSE G0000003 0797 3293
ankyrin 8738
repeat
domains
protein 1
Ig heavy IGG IPI006062 HVM46_ Q53VR3 0.42371 0.00 1 0 0 287.261 0 0 0 0 0 0 0
chain V 54.1 MOUSE 0797 6291
region
MOPC 315
Protein Fam183 UK IPI006062 F183B_M Q5NC57 ENSMUS 75429 0.42371 1000.00 1 0 0 0 0 0 37.3495 0 0 0 0
FAM183B b 69.1 OUSE G0000004 0797 3593
9154
60S Gm805 RIB IPI006066 D3YVN8 D3YVN8 ENSMUS 0.42371 0.00 2 0 0 100.922 0 0 0 0 0 0 0
ribosomal 4 15.1 _MOUSE G0000006 0797 1099
protein L21 9986
Protein Fam190 UK IPI006067 F190B_M Q3UHI0 ENSMUS 72972 0.42371 1000.00 2 0 0 0 0 0 0 0 0 497.829 0
FAM190B b 37.2 OUSE G0000005 0797 0327
8690
Uncharacte UK IPI006204 CS057_M Q6DIA7 ENSMUS 74666 0.42371 0.00 1 0 0 0 0 267.296 0 0 0 0 0
rized 50.2 OUSE G0000000 0797 8657
protein 8129
C19orf57
homolog
Periodic Pwp1 TF IPI006206 PWP1_M Q8BW04 ENSMUS 103136 0.42371 1000.00 1 0 0 0 0 0 870.770 0 0 0 0
tryptophan 53.2 OUSE G0000000 0797 9171
protein 1 1785
homolog
Nuclear Ncor1 TF IPI006206 NCOR1_ Q60974 0.42371 1000.00 3 0 0 0 0 0 218.324 0 0 0 0

- 105 -
receptor 82.1 MOUSE 0797 0959
corepressor
1
ALK Alk RCP IPI006209 ALK_MO P97793 ENSMUS 11682 0.42371 1000.00 1 0 0 0 0 0 0 0 59.4739 0 0
tyrosine 00.4 USE G0000005 0797 2925
kinase 5471
receptor
CAD Cad ENZ IPI006209 Q7TN13_ Q7TN13 69719 0.42371 1000.00 1 0 0 0 0 0 122.902 0 0 0 0
protein 56.3 MOUSE 0797 3466
AP-1 Ap1g1 TP IPI006214 AP1G1_ P22892 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 40.0615 0 0 0
complex 60.2 MOUSE G0000003 0797 0256
subunit 1731
gamma-1
NACHT, Nlrp3 SIG IPI006217 NALP3_ Q8R4B8 ENSMUS 216799 0.42371 0.00 1 0 0 0 459.055 0 0 0 0 0 0
LRR and 84.1 MOUSE G0000003 0797 0777
PYD 2691
domains-
containing
protein 3
Dynein Dnahc1 CS IPI006221 E9Q7N9_ E9Q7N9 ENSMUS 13411 0.42371 0.00 1 0 0 0 0 2260.47 0 0 0 0 0
heavy chain 1 22.5 MOUSE G0000001 0797 6227
11, 8581
axonemal
Protein Wdr95 UK IPI006224 D3Z7A8_ E9PUB4 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 150.500
Wdr95 51.3 MOUSE G0000002 0797 6427
9658
Probable Trip12 ENZ IPI006235 Q8K051_ Q8BM59 0.42371 0.00 1 0 0 31.4646 0 0 0 0 0 0 0
E3 70.3 MOUSE 0797 1051
ubiquitin-
protein
ligase
TRIP12
UPF0705 UK IPI006237 CK049_M A2AII6 ENSMUS 228356 0.42371 1000.00 1 0 0 0 0 0 0 0 109.793 0 0
protein 15.2 OUSE G0000004 0797 1166
C11orf49 0591
homolog
Probable Atp13a TP IPI006238 AT131_M E9PZQ3 ENSMUS 170759 0.42371 0.00 2 218.286 0 0 0 0 0 0 0 0 0
cation- 1 42.5 OUSE G0000003 0797 9002
transporting 1862
ATPase
13A1
Histone Hist2h2 TF IPI006239 H2A2B_ Q64522 ENSMUS 621893 0.42371 1000.00 2 0 0 0 0 0 0 0 0 2810.40 0
H2A type ab 51.3 MOUSE G0000006 0797 8497
2-B 3689
Probable Setx ENZ IPI006262 SETX_M A2AKX3 ENSMUS 269254 0.42371 0.00 2 0 444.451 0 0 0 0 0 0 0 0
helicase 71.3 OUSE G0000004 0797 4734
senataxin 3535
Rho Arhgef4 MOD IPI006266 ARH40_ Q3UPH7 ENSMUS 268739 0.42371 1000.00 1 0 0 0 0 0 0 0 0 136.909 0
guanine 0 88.3 MOUSE G0000000 0797 0092
nucleotide 4562
exchange
factor 40
Unconventi Myo15a CS IPI006270 MYO15_ E9PWS8 ENSMUS 17910 0.42371 1000.00 1 0 0 0 0 0 0 91.0036 0 0 0
onal 42.3 MOUSE G0000004 0797 9877
myosin-XV 2678
Condensin- Ncapd3 CC IPI006270 CNDD3_ Q6ZQK0 ENSMUS 78658 0.42371 0.00 1 0 240.196 0 0 0 0 0 0 0 0

- 106 -
2 complex 45.4 MOUSE G0000003 0797 7677
subunit D3 5024
Serine/thre Pdik1l ENZ IPI006479 PDK1L_ A2A9L1 ENSMUS 230809 0.42371 0.00 1 0 0 25.5749 0 0 0 0 0 0 0
onine- 68.3 MOUSE G0000005 0797 2968
protein 0890
kinase
PDIK1L
Protein Unc13d TP IPI006480 UN13D_ A2A858 ENSMUS 70450 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 66.8629
unc-13 98.2 MOUSE G0000005 0797 9041
homolog D 7948
Cell death Cidec MOD IPI006481 CIDEC_ Q499X5 ENSMUS 14311 0.42371 1000.00 1 0 0 0 0 0 13.7603 0 0 0 0
activator 72.1 MOUSE G0000003 0797 6035
CIDE-3 0278
Protein Tanc2 UK IPI006484 TANC2_ A2A690 ENSMUS 77097 0.42371 0.00 1 0 0 74.6657 0 0 0 0 0 0 0
TANC2 38.1 MOUSE G0000005 0797 7191
3580
Exosome Exosc3 TF IPI006487 EXOS3_ F6TGV1 ENSMUS 66362 0.42371 0.00 1 0 0 137.285 0 0 0 0 0 0 0
complex 02.3 MOUSE G0000002 0797 3618
component 8322
RRP40
Zinc finger Zfp454 TF IPI006488 Q80Y34_ Q8BIK0 ENSMUS 237758 0.42371 1000.00 1 0 0 0 0 0 0 83.3639 0 0 0
protein 454 03.2 MOUSE G0000004 0797 8579
8728
Ankyrin Ankrd6 MOD IPI006491 ANKR6_ Q69ZU8 ENSMUS 140577 0.42371 0.00 1 0 0 369.286 0 0 0 0 0 0 0
repeat 72.1 MOUSE G0000004 0797 7915
domain- 0183
containing
protein 6
ELAV-like Elavl4 TF IPI006492 ELAV4_ Q8BVA9 ENSMUS 15572 0.42371 0.00 1 0 0 0 42.8831 0 0 0 0 0 0
protein 4 29.1 MOUSE G0000002 0797 1864
8546
Filamin- Fblim1 CS IPI006496 FBLI1_M A2ADF3 ENSMUS 74202 0.42371 0.00 1 0 0 41.9962 0 0 0 0 0 0 0
binding 99.1 OUSE G0000000 0797 3564
LIM 6219
protein 1
Centrosoma Cep85 CS IPI006497 CEP85_M Q8VDN9 ENSMUS 70012 0.42371 1000.00 2 0 0 0 0 0 277.253 0 0 0 0
l protein of 27.1 OUSE G0000003 0797 4481
85 kDa 7443
Polynucleot Nol9 ENZ IPI006498 NOL9_M Q3TZX8 ENSMUS 74035 0.42371 0.00 2 637.500 0 0 0 0 0 0 0 0 0
ide 5'- 15.2 OUSE G0000002 0797 4868
hydroxyl- 8948
kinase
NOL9
Gem- Gemin5 TF IPI006498 GEMI5_ F7CKD6 ENSMUS 216766 0.42371 1000.00 1 0 0 0 0 0 0 23.1015 0 0 0
associated 72.2 MOUSE G0000003 0797 7543
protein 5 7275
1- Plch2 ENZ IPI006498 PLCH2_ A2AP18 ENSMUS 269615 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 58.9821
phosphatid 74.3 MOUSE G0000002 0797 6296
ylinositol 9055
4,5-
bisphosphat
e
phosphodie
sterase eta-
2
Intraflagell Ift74 TP IPI006500 IFT74_M Q8CGJ7 ENSMUS 67694 0.42371 1000.00 1 0 0 0 0 0 0 36.8990 0 0 0

- 107 -
ar transport 60.1 OUSE G0000002 0797 5488
protein 74 8576
homolog
Putative 170006 UK IPI006517 Q3V2K2_ Q3V2K2 0.42371 0.00 1 130.655 0 0 0 0 0 0 0 0 0
uncharacter 2I23Rik 96.1 MOUSE 0797 7689
ized protein
1700062I23
Rik
Multiple Minpp1 ENZ IPI006520 MINP1_ Q8C9C2 ENSMUS 17330 0.42371 0.00 1 60.3351 0 0 0 0 0 0 0 0 0
inositol 93.1 MOUSE G0000002 0797 8332
polyphosph 4896
ate
phosphatas
e1
Putative Gm658 UK IPI006523 Q3V040_ Q3V040 625464 0.42371 0.00 1 0 0 123.509 0 0 0 0 0 0 0
uncharacter 8 89.4 MOUSE 0797 2997
ized protein
Gm6588
Ras- Rreb1 TF IPI006524 RREB1_ Q3UH06 ENSMUS 68750 0.42371 0.00 1 0 0 0 0 476.107 0 0 0 0 0
responsive 15.2 MOUSE G0000003 0797 0646
element- 9087
binding
protein 1
Protein Gm689 UK IPI006525 Q3USS0_ Q3USS0 ENSMUS 0.42371 0.00 1 0 0 221.940 0 0 0 0 0 0 0
Gm6899 9 00.1 MOUSE G0000006 0797 6997
8314
Probable Ddx49 ENZ IPI006526 DDX49_ Q3UTV0 ENSMUS 234374 0.42371 0.00 1 0 0 98.6556 0 0 0 0 0 0 0
ATP- 92.1 MOUSE G0000005 0797 2796
dependent 7788
RNA
helicase
DDX49
E3 Cbll1 ENZ IPI006527 HAKAI_ Q9JIY2 ENSMUS 104836 0.42371 1000.00 1 0 0 0 0 0 0 49.3099 0 0 0
ubiquitin- 47.2 MOUSE G0000002 0797 1203
protein 0659
ligase
Hakai
Protein Hook2 TP IPI006528 HOOK2_ E9Q974 ENSMUS 170833 0.42371 0.00 2 0 245.697 0 0 0 0 0 0 0 0
Hook 64.4 MOUSE G0000005 0797 1427
homolog 2 2566
Putative Fam63b UK IPI006529 Q3UMW4 Q3UMW4 0.42371 0.00 1 46.3285 0 0 0 0 0 0 0 0 0
uncharacter 99.1 _MOUSE 0797 3544
ized protein
Fam63b
Putative A63007 UK IPI006530 Q3U5B0_ Q3U5B0 0.42371 0.00 1 54.2902 0 0 0 0 0 0 0 0 0
uncharacter 2L19Ri 58.1 MOUSE 0797 2809
ized protein k
A630072L1
9Rik
Alpha- Man2a2 ENZ IPI006530 MA2A2_ Q3TSU5 ENSMUS 140481 0.42371 1000.00 1 0 0 0 0 0 0 0 0 77.9261 0
mannosidas 75.1 MOUSE G0000003 0797 0086
e 2x 8886
UK IPI006532 Q3UR48 0.42371 1000.00 1 0 0 0 0 0 0 55.2433 0 0 0
30.1 0797 4087
Squalene Sqle ENZ IPI006532 ERG1_M Q3TSS7 ENSMUS 20775 0.42371 0.00 1 0 0 0 714.001 0 0 0 0 0 0
monooxyge 56.1 OUSE G0000002 0797 7181

- 108 -
nase 2351
Suppressio St5 SIG IPI006534 ST5_MO Q3TYX0 ENSMUS 76954 0.42371 1000.00 2 0 0 0 0 0 0 0 128.311 0 0
n of 85.1 USE G0000003 0797 3288
tumorigenic 1024
ity 5
protein
Putative BC0313 UK IPI006534 Q3TEN3_ Q3TRV2 0.42371 0.00 1 0 0 0 141.902 0 0 0 0 0 0
uncharacter 61 97.1 MOUSE 0797 44
ized protein
BC031361
Treacle Tcof1 TP IPI006537 TCOF_M Q3TBZ3 ENSMUS 21453 0.42371 1000.00 1 0 0 0 0 0 0 0 0 111.571 0
protein 17.3 OUSE G0000002 0797 4746
4613
Guanylate Gbp4 MOD IPI006538 A4UUI3_ Q3U2C0 ENSMUS 17472 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 58.7588
binding 53.1 MOUSE G0000007 0797 0289
protein 4.1 9363
Erythrocyte Epb42 CS IPI006539 EPB42_M Q3TYT5 ENSMUS 13828 0.42371 1000.00 4 0 0 0 0 0 0 79.5657 0 0 0
membrane 18.2 OUSE G0000002 0797 7694
protein 3216
band 4.2
Protein Zfp940 TF IPI006540 Q8R2Q3_ Q3UVK2 ENSMUS 233057 0.42371 0.00 1 0 39.2054 0 0 0 0 0 0 0 0
Zfp940 37.2 MOUSE G0000005 0797 5093
0855
Carbohydra Chst14 ENZ IPI006542 CHSTE_ A2AQV2 ENSMUS 72136 0.42371 0.00 1 0 0 57.0468 0 0 0 0 0 0 0
te 09.2 MOUSE G0000007 0797 4928
sulfotransfe 4916
rase 14
Ras-related Rab4b TP IPI006542 RAB4B_ Q3USC3 ENSMUS 19342 0.42371 1000.00 2 0 0 0 0 0 0 0 259.944 0 0
protein 55.1 MOUSE G0000005 0797 7197
Rab-4B 3291
Ras- Radil CS IPI006549 RADIL_ Q69Z89 ENSMUS 231858 0.42371 0.00 1 0 0 0 0 1968.81 0 0 0 0 0
associating 33.1 MOUSE G0000002 0797 1778
and dilute 9576
domain-
containing
protein
Transient Trpm3 CNL IPI006549 E9PUC8_ E9PUC8 ENSMUS 226025 0.42371 0.00 2 218.046 0 0 0 0 0 0 0 0 0
receptor 41.1 MOUSE G0000005 0797 047
potential 2387
cation
channel
subfamily
M member
3
Bifunctiona Mgea5 ENZ IPI006551 NCOAT_ Q9EQQ9 ENSMUS 76055 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 128.254
l protein 75.2 MOUSE G0000002 0797 2842
NCOAT 5220
Transmemb Tmc5 TP IPI006561 TMC5_M Q32NZ6 ENSMUS 74424 0.42371 1000.00 2 0 0 0 0 0 122.921 0 0 0 0
rane 68.1 OUSE G0000003 0797 6537
channel- 0650
like protein
5
RNA- Rbm6 TF IPI006562 Q8R388_ Q3ULB0 ENSMUS 0.42371 1000.00 2 0 0 0 0 0 0 0 81.3115 0 0
binding 34.1 MOUSE G0000003 0797 7707
protein 6 2582
Treslin Ticrr CC IPI006562 TICRR_ Q8BQ33 ENSMUS 77011 0.42371 0.00 1 0 0 0 112.468 0 0 0 0 0 0

- 109 -
 83.1 MOUSE G0000004 0797 7324
6591
Vesicle- Nsf TP IPI006563 NSF_MO P46460 ENSMUS 18195 0.42371 1000.00 2 0 0 0 0 0 113.754 0 0 0 0
fusing 25.2 USE G0000003 0797 241
ATPase 4187
Inhibitor of Ibtk INH IPI006607 IBTK_M Q6ZPR6 ENSMUS 108837 0.42371 1000.00 1 0 0 0 0 0 42.2840 0 0 0 0
Bruton 67.3 OUSE G0000003 0797 482
tyrosine 5941
kinase
Homeobox Dbx2 TF IPI006618 F8VQH7_ F8VQH7 ENSMUS 223843 0.42371 0.00 1 0 133.793 0 0 0 0 0 0 0 0
protein 86.2 MOUSE G0000004 0797 7045
DBX2 5608
60S Rpl13a RIB IPI006621 RL13A_ P19253/Q ENSMUS 22121 0.42371 0.26 3 0 0 0 136.417 0 0 0 0 0 35.3705
ribosomal 96.3/IPI00 MOUSE 3TDS9 G0000007 0797 0402 6915
protein 654400.1 4129
L13a
Glycogen Agl ENZ IPI006622 F8VPN4_ F8VPN4 ENSMUS 77559 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 195.695
debranchin 44.2 MOUSE G0000003 0797 1431
g enzyme 3400
2010300C0 201030 UK IPI006624 Q6GQT3_ Q8K303 72097 0.42371 0.00 2 0 0 2144.77 0 0 0 0 0 0 0
2Rik 0C02Ri 08.4 MOUSE 0797 5045
protein k
High Ntrk1 RCP IPI006624 NTRK1_ Q3UFB7 ENSMUS 18211 0.42371 1000.00 1 0 0 0 0 0 41.7997 0 0 0 0
affinity 72.2 MOUSE G0000002 0797 4906
nerve 8072
growth
factor
receptor
Ig heavy IGG IPI006636 HVM13_ P01757 0.42371 0.00 1 0 185.594 0 0 0 0 0 0 0 0
chain V 02.4 MOUSE 0797 4109
region J558
Nuclear Nrbp1 SCA IPI006642 NRBP_M D3YUV1 ENSMUS 192292 0.42371 0.00 1 0 132.506 0 0 0 0 0 0 0 0
receptor- 46.4 OUSE G0000002 0797 8706
binding 9148
protein
Teashirt Tshz1 TF IPI006644 TSH1_M Q5DTH5 ENSMUS 110796 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 395.122
homolog 1 19.1 OUSE G0000004 0797 0168
6982
Lysine- Kdm3b ENZ IPI006648 KDM3B_ Q6ZPY7 ENSMUS 0.42371 0.00 4 413.470 0 0 0 0 0 0 0 0 0
specific 08.2 MOUSE G0000003 0797 9404
demethylas 8773
e 3B
Core H2afy TF IPI006655 H2AY_M Q9CTH9 ENSMUS 26914 0.42371 0.00 2 0 0 0 0 78.6510 0 0 0 0 0
histone 57.4 OUSE G0000001 0797 4218
macro- 5937
H2A.1
Leucine- Lgr4 RCP IPI006670 LGR4_M A2ARI3 ENSMUS 107515 0.42371 1000.00 1 0 0 0 0 0 0 45.3131 0 0 0
rich repeat- 18.2 OUSE G0000005 0797 8975
containing 0199
G-protein
coupled
receptor 4
Tetratricop Ttc17 UK IPI006672 E9PVB5_ Q8C1H7 ENSMUS 74569 0.42371 1000.00 1 0 0 0 0 0 186.659 0 0 0 0
eptide 68.4 MOUSE G0000002 0797 5349
repeat 7194
protein 17

- 110 -
Cell surface Mcam CS IPI006677 MUC18_ Q8R2Y2 ENSMUS 84004 0.42371 0.00 1 0 0 41.6768 0 0 0 0 0 0 0
glycoprotei 48.1 MOUSE G0000003 0797 8815
n MUC18 2135
Phosphatid Prex1 MOD IPI006684 PREX1_ A2A5T9 ENSMUS 277360 0.42371 0.00 1 90.8496 0 0 0 0 0 0 0 0 0
ylinositol 33.1 MOUSE G0000003 0797 0958
3,4,5- 9621
trisphospha
te-
dependent
Rac
exchanger 1
protein
Protein Unc79 CNL IPI006688 UNC79_ Q0KK59 ENSMUS 217843 0.42371 0.00 1 0 0 33.9337 0 0 0 0 0 0 0
unc-79 72.2 MOUSE G0000002 0797 5284
homolog 1198
Zinc finger Zfp498 TF IPI006697 B9EKU2_ B2RX31 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 123.568 0 0
protein 498 02.4 MOUSE G0000007 0797 4723
0420
Protein Gpr108 TM IPI006697 GP108_M Q91WD0 ENSMUS 78308 0.42371 0.00 1 62.2930 0 0 0 0 0 0 0 0 0
GPR108 11.1 OUSE G0000000 0797 3132
5823
Cytosolic Acot7 ENZ IPI006725 BACH_M Q91V12 ENSMUS 70025 0.42371 0.00 1 0 0 0 0 33.5621 0 0 0 0 0
acyl 08.1 OUSE G0000002 0797 3175
coenzyme 8937
A thioester
hydrolase
Mitogen- Map3k1 ENZ IPI006725 M3K10_ Q66L42 ENSMUS 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 113.201
activated 0 25.3 MOUSE G0000004 0797 1969
protein 0390
kinase
kinase
kinase 10
Zinc finger Zfp407 TF IPI006789 G3UVV3 Q69ZC9 ENSMUS 240476 0.42371 1000.00 4 0 0 0 0 0 365.017 0 0 0 0
protein 407 85.3 _MOUSE G0000004 0797 2619
8410
Cysteine- Cypt7 UK IPI007423 Q3MSC9 Q3MSC9 664725 0.42371 0.00 1 0 0 0 0 272.496 0 0 0 0 0
rich 35.1 _MOUSE 0797 0551
perinuclear
theca
protein 7
G-protein- Gpsm1 MOD IPI007497 GPSM1_ A2AIV4 ENSMUS 67839 0.42371 1000.00 1 0 0 0 0 0 0 141.769 0 0 0
signaling 99.1 MOUSE G0000002 0797 1109
modulator 6930
1
DNA- Polr1b TF IPI007499 RPA2_M A2AP84 ENSMUS 20017 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 300.422
directed 88.1 OUSE G0000002 0797 1584
RNA 7395
polymerase
I subunit
RPA2
60S Rpl6 RIB IPI007503 RL6_MO D3Z4I7 ENSMUS 19988 0.42371 0.00 1 34.0220 0 0 0 0 0 0 0 0 0
ribosomal 33.2 USE G0000005 0797 8826
protein L6 7605|ENS
MUSG00
00002961
4

- 111 -
Diacylglyce Dgkz ENZ IPI007504 DGKZ_M A2AHJ7 ENSMUS 104418 0.42371 0.00 1 0 0 75.6014 0 0 0 0 0 0 0
rol kinase 46.1 OUSE G0000004 0797 5145
zeta 0479
Uncharacte UK IPI007505 CQ100_M Q8BGJ3 75304 0.42371 0.00 1 21.1789 0 0 0 0 0 0 0 0 0
rized 27.3 OUSE 0797 5574
protein
C17orf100
homolog
Pre- Cwc22 TF IPI007505 CWC22_ Q499E2 ENSMUS 80744 0.42371 1000.00 2 0 0 0 0 0 0 147.981 0 0 0
mRNA- 46.1 MOUSE G0000002 0797 8454
splicing 7014
factor
CWC22
homolog
Guanine Gnas SIG IPI007505 GNAS2_ A2A611 ENSMUS 14683 0.42371 0.00 2 0 0 227.748 0 0 0 0 0 0 0
nucleotide- 70.1 MOUSE G0000002 0797 7348
binding 7523
protein G(s)
subunit
alpha
isoforms
short
Aryl Arnt TF IPI007509 ARNT_M Q5DTR2 ENSMUS 11863 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 764.020
hydrocarbo 23.1 OUSE G0000001 0797 6257
n receptor 5522
nuclear
translocator
Coiled-coil Ccdc15 UK IPI007509 E9PX14_ E9PX14 ENSMUS 10003913 0.42371 1000.00 1 0 0 0 0 0 421.036 0 0 0 0
domain- 2 64.3 MOUSE G0000009 9 0797 1986
containing 1119
protein 152
Novel D73003 UK IPI007513 Q9D1U5_ A2AUB1 ENSMUS 77996 0.42371 0.00 1 0 0 59.0780 0 0 0 0 0 0 0
protein 9F16Ri 78.1 MOUSE G0000002 0797 9717
k 6870
Zinc finger Zfc3h1 TF IPI007516 Q6A049_ Q6A049 216345 0.42371 1000.00 2 0 0 0 0 0 0 0 0 166.051 0
C3H1 28.1 MOUSE 0797 6939
domain-
containing
protein
Sickle tail Skt DEV IPI007523 SKT_MO A2AQ25 ENSMUS 208618 0.42371 0.00 2 320.916 0 0 0 0 0 0 0 0 0
protein 98.1 USE G0000003 0797 3936
6617
Disabled Dab2ip MOD IPI007531 DAB2P_ Q3UHC7 ENSMUS 69601 0.42371 0.00 1 0 0 111.054 0 0 0 0 0 0 0
homolog 2- 48.2 MOUSE G0000002 0797 7265
interacting 6883
protein
MCG22096 Gm103 ENZ IPI007544 D6MZJ6_ D6MZJ6 ENSMUS 10050391 0.42371 1000.00 1 0 0 0 0 0 0 0 112.104 0 0
, Gm10345, 45 60.3 MOUSE G0000007 5 0797 5052
Sphingomy 1724
elin
phosphodie
sterase 5
Ribosome- Rrbp1 TP IPI007551 RRBP1_ Q6ZPS0/ ENSMUS 81910 0.42371 0.11 7 0 0 0 547.533 0 0 0 0 61.7397 0
binding 20.2/IPI00 MOUSE Q99PL5 G0000002 0797 0598 2807
protein 1 121149.1 7422
Translocon- Ssr1 CHA IPI007553 SSRA_M Q9CY50 ENSMUS 107513 0.42371 0.00 1 0 0 0 93.0788 0 0 0 0 0 0

- 112 -
associated 29.1 OUSE G0000002 0797 5278
protein 1427
subunit
alpha
Glucosamin Gfpt1 ENZ IPI007555 GFPT1_ P47856 ENSMUS 14583 0.42371 0.00 2 59.5100 0 0 0 0 0 0 0 0 0
e--fructose- 49.2 MOUSE G0000002 0797 6069
6- 9992
phosphate
aminotransf
erase
[isomerizin
g] 1
Synaptic Sv2c TP IPI007558 SV2C_M Q69ZS6 ENSMUS 75209 0.42371 0.00 1 0 0 97.2761 0 0 0 0 0 0 0
vesicle 59.1 OUSE G0000005 0797 3517
glycoprotei 1111
n 2C
60S Gm897 RIB IPI007559 D3YX71_ D3YX71 ENSMUS 0.42371 0.00 4 0 444.343 626.824 0 0 0 0 0 0 0
ribosomal 3 59.1/IPI00 MOUSE G0000006 0797 6301 4076
protein L36 988965.1 4081
Cordon- Cobll1 UK IPI007563 COBL1_ Q3UMF0 ENSMUS 319876 0.42371 1000.00 2 0 0 0 0 0 111.678 0 0 0 0
bleu 91.3 MOUSE G0000003 0797 8331
protein-like 4903
1
Eukaryotic Eif5b TF IPI007564 IF2P_MO Q05D44 ENSMUS 226982 0.42371 1000.00 1 0 0 0 0 0 221.868 0 0 0 0
translation 24.3 USE G0000002 0797 7167
initiation 6083
factor 5B
Armadillo Armcx4 TM IPI007566 E9PWM3 A2VCS7 ENSMUS 10050304 0.42371 1000.00 1 0 0 0 0 0 0 0 0 59.8464 0
repeat- 11.3 _MOUSE G0000004 3 0797 6028
containing 9804
X-linked
protein 4
REST Rcor2 TF IPI007568 RCOR2_ Q9JMK4 ENSMUS 104383 0.42371 1000.00 1 0 0 0 0 0 0 75.3768 0 0 0
corepressor 36.1 MOUSE G0000002 0797 6123
2 4968
Rho Arhgap MOD IPI007571 RHGBA_ A2AL18 ENSMUS 228482 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 69.4764
GTPase- 11a 54.1 MOUSE G0000004 0797 6466
activating 1219
protein 11A
Cortactin- Cttnbp2 UK IPI007572 F6Q1W8_ Q8C044 ENSMUS 0.42371 1000.00 3 0 0 0 0 0 0 0 386.339 0 0
binding 50.3 MOUSE G0000000 0797 3589
protein 2 0416
Rho Arhgap MOD IPI007573 RHG42_ B2RQE8 ENSMUS 71544 0.42371 0.00 1 0 0 0 263.726 0 0 0 0 0 0
GTPase- 42 35.4 MOUSE G0000005 0797 3343
activating 0730
protein 42
26S Psmc3 MOD IPI007580 PRS6A_ A2AGN7 ENSMUS 19182 0.42371 1000.00 1 0 0 0 0 0 0 384.556 0 0 0
protease 64.1 MOUSE G0000000 0797 4362
regulatory 2102
subunit 6A
Death- Dido1 TF IPI007581 DIDO1_ Q80V34/ ENSMUS 23856 0.42371 1000.00 3 0 0 0 0 0 346.092 0 0 0 71.4912
inducer 32.1/IPI00 MOUSE Q8C9B9 G0000003 0797 1134 2426
obliterator 828403.1 8914
1
Exportin-7 Xpo7 TP IPI007600 XPO7_M Q9EPK7 ENSMUS 65246 0.42371 1000.00 1 0 0 0 0 0 0 14.0250 0 0 0
95.2 OUSE G0000002 0797 2892

- 113 -
 2100
E3 Hectd3 ENZ IPI007612 HECD3_ Q3U487 ENSMUS 76608 0.42371 0.00 1 0 0 69.7792 0 0 0 0 0 0 0
ubiquitin- 71.1 MOUSE G0000004 0797 6305
protein 6861
ligase
HECTD3
Putative Gm168 IGG IPI007612 Q9DCD9 Q9DCD9 0.42371 1000.00 1 0 0 0 0 0 20.1431 0 0 0 0
uncharacter 44 77.3 _MOUSE 0797 1018
ized protein
Gm16844
Trafficking Trappc8 TP IPI007614 Q811K7_ Q9CU98 0.42371 0.00 1 0 0 90.7300 0 0 0 0 0 0 0
protein 29.2 MOUSE 0797 4247
particle
complex
subunit 8
Sodium Scn2a1 TP IPI007616 Q8CCS4_ Q8CAJ8 0.42371 0.00 1 63.0232 0 0 0 0 0 0 0 0 0
channel 41.1 MOUSE 0797 7418
protein type
2 subunit
alpha
Contactin-2 Cntn2 CS IPI007619 CNTN2_ Q3UY89 ENSMUS 21367 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 28.6755
38.3 MOUSE G0000005 0797 3869
3024
Nuclear Ncoa3 ENZ IPI007619 NCOA3_ O09000 0.42371 1000.00 1 0 0 0 0 0 22.8565 0 0 0 0
receptor 76.1 MOUSE 0797 2826
coactivator
3
DENN Dennd4 UK IPI007621 DEN4B_ Q3U1Y4 ENSMUS 229541 0.42371 1000.00 1 0 0 0 0 0 0 18.4056 0 0 0
domain- b 64.3 MOUSE G0000004 0797 1014
containing 2404
protein 4B
Transforma Trrap TF IPI007622 E9QLK7_ Q8BW25 ENSMUS 100683 0.42371 0.00 2 57.3687 0 0 0 0 0 0 0 0 0
tion/transcri 14.3 MOUSE G0000004 0797 0241
ption 5482
domain-
associated
protein
Dynein Dnah12 CS IPI007623 DYH12_ Q3V0Q1 0.42371 0.00 2 152.461 0 0 0 0 0 0 0 0 0
heavy chain 50.3 MOUSE 0797 0697
12,
axonemal
H-2 class I H2-K1 MHC IPI007625 HA1W_M Q61896 0.42371 1000.00 2 0 0 0 0 0 33.2634 0 0 0 0
histocompa 95.1 OUSE 0797 2391
tibility
antigen, K-
W28 alpha
chain
Outcome Wbp1l TM IPI007628 OPA1L_ P58281 ENSMUS 226178 0.42371 1000.00 1 0 0 0 0 0 0 156.217 0 0 0
predictor in 82.1 MOUSE G0000003 0797 0666
acute 8084|ENS
leukemia 1 MUSG00
homolog 00004773
1
Coiled-coil Cc2d2a CS IPI007758 C2D2A_ F6YZ61/ ENSMUS 231214 0.42371 0.12 4 0 0 0 0 655.084 0 0 0 75.4735 0
and C2 15.1/IPI00 MOUSE Q8CFW7 G0000003 0797 8161 2969
domain- 229425.2 9765

- 114 -
containing
protein 2A
Tubulin Ttll3 ENZ IPI007758 TTLL3_ F8VQA1 ENSMUS 101100 0.42371 0.00 1 75.9636 0 0 0 0 0 0 0 0 0
monoglycyl 72.2 MOUSE G0000003 0797 1294
ase TTLL3 0276
tyrosine- Jak1 ENZ IPI007759 JAK1_M B1ASP2 ENSMUS 0.42371 0.00 2 326.260 0 0 0 0 0 0 0 0 0
protein 93.1 OUSE G0000002 0797 7202
kinase 8530
JAK1
SH2 Shd SCA IPI007760 SHD_MO O88834 ENSMUS 20420 0.42371 1000.00 1 0 0 0 0 0 0 64.3626 0 0 0
domain- 00.1 USE G0000003 0797 9292
containing 9154
adapter
protein D
Protein Ddx26b UK IPI007761 DX26B_ F6WNG1 ENSMUS 236790 0.42371 1000.00 1 0 0 0 0 0 0 144.399 0 0 0
DDX26B 93.1 MOUSE G0000003 0797 7199
5967
E3 Uhrf2 CC IPI007761 UHRF2_ Q3T995 ENSMUS 109113 0.42371 0.00 1 0 0 198.801 0 0 0 0 0 0 0
ubiquitin- 98.1 MOUSE G0000002 0797 8889
protein 4817
ligase
UHRF2
Lethal(3)m L3mbtl TF IPI007762 LMBL1_ Q3V557 ENSMUS 241764 0.42371 0.00 1 0 132.266 0 0 0 0 0 0 0 0
alignant 1 46.2 MOUSE G0000003 0797 4494
brain 5576
tumor-like
protein 1
SET Setd5 UK IPI007762 SETD5_ Q5XJV7 ENSMUS 72895 0.42371 0.00 1 46.3326 0 0 0 0 0 0 0 0 0
domain- 53.2 MOUSE G0000003 0797 9102
containing 4269
protein 5
F-actin- Capzb CS IPI007762 CAPZB_ A2AMV8 ENSMUS 12345 0.42371 1.33 5 0 100.498 0 0 71.4400 0 0 0 0 114.483
capping 65.1/IPI00 MOUSE /A2AMW G0000002 0797 6356 5914 4184
protein 776140.1/ 0/F7CAZ 8745
subunit IPI007763 6
beta 74.1
Interleukin Ilf3 TF IPI007763 ILF3_MO Q45VK5 ENSMUS 16201 0.42371 1000.00 2 0 0 0 0 0 0 36.6081 0 0 0
enhancer- 84.1 USE G0000003 0797 3815
binding 2178
factor 3
Protein fat- Ffr TP IPI007854 FFR_MO Q3UVL4 ENSMUS 68505 0.42371 1000.00 1 0 0 0 0 0 0 0 20.8471 0 0
free 07.1 USE G0000002 0797 6009
homolog 4797
ENSMUSG Gm108 IGG IPI007855 Q52L64_ Q52L64 0.42371 0.00 3 0 351.331 0 0 0 0 0 0 0 0
000000765 83 09.1 MOUSE 0797 5864
77 protein
Gm10883
Tight Tjp3 CS IPI007884 ZO3_MO Q921G9 ENSMUS 0.42371 0.00 1 0 45.4806 0 0 0 0 0 0 0 0
junction 50.1 USE G0000003 0797 4374
protein ZO- 4917
3
ATP- Abca13 TP IPI007985 ABCAD_ Q5SSE9 ENSMUS 268379 0.42371 1000.00 1 0 0 0 0 0 0 56.9378 0 0 0
binding 57.1 MOUSE G0000000 0797 899
cassette 4668
sub-family
A member

- 115 -
13
SCY1-like Scyl2 CS IPI007985 SCYL2_ Q8CFE4 ENSMUS 213326 0.42371 0.00 1 0 58.6743 0 0 0 0 0 0 0 0
protein 2 71.2 MOUSE G0000006 0797 4752
9539
Protein C03004 UK IPI008078 Q8BT39_ Q8BT39 ENSMUS 0.42371 0.00 1 0 0 153.963 0 0 0 0 0 0 0
C030048H 8H21Ri 11.2 MOUSE G0000009 0797 8897
21Rik k 0340
Protein E33001 UK IPI008078 Q8C6L5_ Q05BI9 ENSMUS 214763 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 220.762
E330016A1 6A19Ri 93.1 MOUSE G0000003 0797 3816
9Rik k 2344
MAP7 Map7d2 UK IPI008080 MA7D2_ A2AG50 ENSMUS 78283 0.42371 1000.00 2 0 0 0 0 0 81.6023 0 0 0 0
domain- 96.3 MOUSE G0000004 0797 8983
containing 1020
protein 2
UK IPI008082 0.42371 1000.00 1 0 0 0 0 0 0 107.589 0 0 0
62.1 0797 9051
BTB/POZ Btbd16 UK IPI008083 BTBDG_ E9Q173 ENSMUS 330660 0.42371 0.00 1 0 0 0 0 211.721 0 0 0 0 0
domain- 66.3 MOUSE G0000004 0797 9911
containing 0298
protein 16
Coiled-coil Ccdc10 UK IPI008085 CC105_M Q9D4K7 0.42371 0.00 1 0 0 251.419 0 0 0 0 0 0 0
domain- 5 65.2 OUSE 0797 8537
containing
protein 105
Serine/thre Braf ENZ IPI008169 BRAF_M P28028 ENSMUS 109880 0.42371 1000.00 1 0 0 0 0 0 0 0 0 69.7177 0
onine- 67.1 OUSE G0000000 0797 933
protein 2413
kinase B-
raf
MAX gene- Mga TF IPI008170 MGAP_M A2AWL7 ENSMUS 29808 0.42371 0.11 2 77.1016 0 0 0 0 0 8.60668 0 0 0
associated 09.2/IPI00 OUSE G0000003 0797 9422 9981
protein 896608.1 3943
Src kinase- Skap2 CS IPI008170 SKAP2_ Q3UND0 ENSMUS 54353 0.42371 0.00 1 0 83.6159 0 0 0 0 0 0 0 0
associated 26.1 MOUSE G0000005 0797 5761
phosphopro 9182
tein 2
Dynein Dnah17 CS IPI008282 DYH17_ Q69Z23 ENSMUS 0.42371 0.00 3 0 0 233.006 0 0 0 0 0 0 0
heavy chain 84.3 MOUSE G0000003 0797 0741
17, 3987
axonemal
Histone- Rbbp4 CC IPI008284 RBBP4_ Q60972 ENSMUS 19646 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 27.0051
binding 12.1 MOUSE G0000005 0797 3728
protein 7236
RBBP4
AF4/FMR2 Aff1 TF IPI008286 AFF1_M A3KMF4 ENSMUS 0.42371 1000.00 2 0 0 0 0 0 0 899.675 0 0 0
family 26.2 OUSE G0000002 0797 4963
member 1 9313
Zinc finger Zcchc4 TF IPI008289 ZCHC4_ Q08EK6 ENSMUS 78796 0.42371 0.00 1 0 0 0 79.8304 0 0 0 0 0 0
CCHC 35.1 MOUSE G0000002 0797 2583
domain- 9179
containing
protein 4
Differential Def8 SIG IPI008301 DEFI8_M D3YWV3 ENSMUS 23854 0.42371 0.00 1 0 0 0 0 402.375 0 0 0 0 0
ly 91.1 OUSE G0000000 0797 625
expressed 1482
in FDCP 8

- 116 -
Semaphorin Sema4f DEV IPI008302 SEM4F_ D3YWP2 ENSMUS 20355 0.42371 0.00 1 0 0 0 361.355 0 0 0 0 0 0
-4F 57.1 MOUSE G0000000 0797 0622
0627
Calpain Capns1 MOD IPI008303 CPNS1_ D3YW48 ENSMUS 12336 0.42371 0.00 1 21.9301 0 0 0 0 0 0 0 0 0
small 35.1 MOUSE G0000000 0797 7243
subunit 1 1794
Synaptopod Synpo2 CS IPI008303 SYNP2_ D3YVV9 ENSMUS 0.42371 0.00 1 0 0 201.684 0 0 0 0 0 0 0
in-2 87.1 MOUSE G0000005 0797 8973
0315
DNA- Apex2 CC IPI008304 APEX2_ A2AFM3 ENSMUS 77622 0.42371 1000.00 1 0 0 0 0 0 0 18.3875 0 0 0
(apurinic or 90.1 MOUSE G0000002 0797 6119
apyrimidini 5269
c site) lyase
2
Highly Hdx TF IPI008305 HDX_MO Q14B70 ENSMUS 245596 0.42371 0.00 1 0 264.072 0 0 0 0 0 0 0 0
divergent 19.1 USE G0000003 0797 4773
homeobox 4551
Protein Zfp882 TF IPI008306 E9Q4R4_ D3Z2V3 ENSMUS 382019 0.42371 0.00 1 42.4502 0 0 0 0 0 0 0 0 0
Zfp882 33.1 MOUSE G0000008 0797 2568
9857
Fibronectin Fndc1 SIG IPI008307 E9Q043_ E9Q043 ENSMUS 68655 0.42371 0.00 1 0 0 0 44.3011 0 0 0 0 0 0
type III 24.1 MOUSE G0000007 0797 7515
domain- 1984
containing
protein 1
Dystrophin- Drp2 CS IPI008307 DRP2_M Q05AA6 ENSMUS 13497 0.42371 1000.00 1 0 0 0 0 0 0 174.668 0 0 0
related 46.1 OUSE G0000000 0797 9541
protein 2 0223
Glycogen Gsk3a ENZ IPI008307 GSK3A_ D3Z7E5 ENSMUS 606496 0.42371 0.00 1 0 0 0 60.0328 0 0 0 0 0 0
synthase 54.1 MOUSE G0000005 0797 4506
kinase-3 7177
alpha
Phosphoryl Phka2 MOD IPI008309 KPB2_M A2AHQ7 ENSMUS 110094 0.42371 0.00 1 0 27.0528 0 0 0 0 0 0 0 0
ase b kinase 37.1 OUSE G0000003 0797 459
regulatory 1295
subunit
alpha, liver
isoform
Methyl- Mbd3 TF IPI008309 MBD3_M D3YTR4 ENSMUS 17192 0.42371 0.00 2 0 0 118.800 0 0 0 0 0 0 0
CpG- 57.1 OUSE G0000003 0797 356
binding 5478
domain
protein 3
WASH Kiaa103 TP IPI008310 WASH7_ Q3UMB9 ENSMUS 319277 0.42371 0.00 1 0 0 81.0968 0 0 0 0 0 0 0
complex 3 49.1 MOUSE G0000003 0797 6065
subunit 7 4560
AT-rich Arid5a TF IPI008310 ARI5A_ Q3U108 ENSMUS 214855 0.42371 0.00 2 285.277 0 0 0 0 0 0 0 0 0
interactive 73.1 MOUSE G0000003 0797 8092
domain- 7447
containing
protein 5A
Synaptojani Synj2 ENZ IPI008310 SYNJ2_M E9Q4P5 ENSMUS 20975 0.42371 1000.00 1 0 0 0 0 0 30.6220 0 0 0 0
n-2 90.1 OUSE G0000002 0797 014
3805
Zinc finger Znf800 TF IPI008311 ZN800_M D3YZL3 ENSMUS 627049 0.42371 0.00 1 0 0 48.4529 0 0 0 0 0 0 0
protein 800 87.1 OUSE G0000003 0797 2647

- 117 -
 9841
Rho Arhgap MOD IPI008313 RHG28_ Q8BN58 ENSMUS 268970 0.42371 0.00 1 60.2127 0 0 0 0 0 0 0 0 0
GTPase- 28 98.1 MOUSE G0000002 0797 9647
activating 4043
protein 28
MCG18394 Fam186 UK IPI008316 D3Z420_ D3Z420 ENSMUS 545136 0.42371 0.00 1 125.977 0 0 0 0 0 0 0 0 0
(Protein b 63.1 MOUSE G0000007 0797 5673
FAM186B) 8907
PAB- Pan2 ENZ IPI008316 PAN2_M Q8BGF7 ENSMUS 103135 0.42371 1000.00 1 0 0 0 0 0 0 0 0 21.2056 0
dependent 85.1 OUSE G0000000 0797 4626
poly(A)- 5682
specific
ribonucleas
e subunit 2
Tubulin Ttll4 ENZ IPI008317 TTLL4_ D3YY08 ENSMUS 67534 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 153.619
polyglutam 12.1 MOUSE G0000003 0797 0026
ylase 3257
TTLL4
Tudor Tdrd12 UK IPI008446 TDR12_ Q9CWU0 ENSMUS 71981 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 469.529
domain- 42.2 MOUSE G0000003 0797 4896
containing 0491
protein 12
PDZ Magix SCA IPI008447 MAGIX_ Q4KL35 ENSMUS 54634 0.42371 0.00 1 39.5753 0 0 0 0 0 0 0 0 0
domain- 68.2 MOUSE G0000003 0797 9685
containing 1147
protein
MAGIX
UDP-N- Ogt ENZ IPI008455 OGT1_M Q8CGY8 ENSMUS 108155 0.42371 0.00 1 0 0 0 0 120.953 0 0 0 0 0
acetylgluco 28.1 OUSE G0000003 0797 675
samine-- 4160
peptide N-
acetylgluco
saminyltran
sferase 110
kDa
subunit
Nestin Nes DEV IPI008456 NEST_M Q6P5H2 ENSMUS 18008 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 34.8927
08.1 OUSE G0000000 0797 9869
4891
Acyl-CoA- Acbd5 TP IPI008457 ACBD5_ Q5XG73 ENSMUS 74159 0.42371 1000.00 1 0 0 0 0 0 0 17.7548 0 0 0
binding 29.1 MOUSE G0000002 0797 8941
domain- 6781
containing
protein 5
NADH- Cyb5r2 ENZ IPI008457 NB5R2_ Q3KNK3 ENSMUS 320635 0.42371 1000.00 1 0 0 0 0 0 0 0 0 97.4509 0
cytochrome 53.1 MOUSE G0000004 0797 8737
b5 8065
reductase 2
Glycerol-3- Gpd1l ENZ IPI008457 GPD1L_ Q3ULJ0 ENSMUS 333433 0.42371 0.00 2 0 0 318.730 0 0 0 0 0 0 0
phosphate 69.1 MOUSE G0000005 0797 1876
dehydrogen 0627
ase 1-like
protein
Alpha- Snca TP IPI008458 SYUA_M O55042 ENSMUS 20617 0.42371 1000.00 2 0 0 0 0 0 0 66.8120 0 0 0
synuclein 03.1 OUSE G0000002 0797 6166
5889

- 118 -
Coiled-coil UK IPI008458 D3YZW0 ENSG000 0.42371 1000.00 1 0 0 0 0 0 35.3376 0 0 0 0
domain- 23.2 00181982 0797 1694
containing
protein 149
SKI family Skor2 TF IPI008485 SKOR2_ A7M7C7 ENSMUS 664805 0.42371 0.00 1 0 0 163.859 0 0 0 0 0 0 0
transcriptio 85.2 MOUSE G0000009 0797 7389
nal 1519
corepressor
2
Kalirin Kalrn ENZ IPI008486 KALRN_ A2CG49 ENSMUS 545156 0.42371 1000.00 1 0 0 0 0 0 0 0 650.791 0 0
08.1 MOUSE G0000006 0797 9314
1751
60S Rpl12 RIB IPI008497 RL12_M Q5BLK0 ENSMUS 269261 0.42371 0.00 1 0 0 0 0 95.0061 0 0 0 0 0
ribosomal 93.1 OUSE G0000006 0797 9086
protein L12 3328|ENS
MUSG00
00003890
0
Uncharacte Gm727 UK IPI008500 B9EK06_ B9EK06 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 121.997 0 0 0
rized 1 87.2 MOUSE G0000009 0797 4539
protein 1204
Gm7271
Protein Gm372 UK IPI008504 E9Q5Q4_ E9Q5Q4 ENSMUS 10004221 0.42371 1000.00 2 0 0 0 0 0 299.062 0 0 0 0
Gm3727 7 44.1 MOUSE G0000009 7 0797 3114
1042
Uncharacte UK IPI008551 CT026_M Q8CEL2 0.42371 1000.00 1 0 0 0 0 0 223.069 0 0 0 0
rized 74.1 OUSE 0797 8606
protein
C20orf26
homolog
Anion Slc4a2 TP IPI008561 B3A2_M D3Z2F1 ENSMUS 20535 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 107.193
exchange 28.1 OUSE G0000002 0797 6284
protein 2 8962
Zinc finger Ikzf4 TF IPI008561 IKZF4_M Q8C208 ENSMUS 22781 0.42371 0.00 1 0 0 0 94.2189 0 0 0 0 0 0
protein Eos 43.1 OUSE G0000000 0797 4236
2578
Alpha- Parva CS IPI008563 PARVA_ Q3UF75 ENSMUS 57342 0.42371 0.00 2 56.6172 0 0 0 0 0 0 0 0 0
parvin 10.1 MOUSE G0000003 0797 8085
0770
Transmemb Tmem8 CS IPI008563 TMM8B_ B1AWJ4 ENSMUS 242409 0.42371 1000.00 1 0 0 0 0 0 114.441 0 0 0 0
rane protein b 53.1 MOUSE G0000007 0797 872
8B 8716
Novel C87977 UK IPI008564 A2A958_ A6PWB1 ENSMUS 97187 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 280.855
oogenesin 33.1 MOUSE G0000004 0797 3228
(Oog) 6262
protein
Heparanase Hpse ENZ IPI008565 HPSE_M D3Z3C3 ENSMUS 15442 0.42371 1000.00 1 0 0 0 0 0 110.646 0 0 0 0
02.1 OUSE G0000003 0797 4486
5273
HAUS Haus3 CS IPI008565 HAUS3_ Q8QZX2 ENSMUS 231123 0.42371 1000.00 1 0 0 0 0 0 39.6100 0 0 0 0
augmin-like 05.1 MOUSE G0000007 0797 9713
complex 9555
subunit 3
Fanconi Fance SCA IPI008567 B8JJD6_ B8JJD2 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 86.7177 0 0 0 0
anemia, 66.1 MOUSE G0000000 0797 2893
complemen 7570

- 119 -
tation
group E
Zinc finger Zbtb49 TF IPI008568 ZBT49_M D6RGS0 ENSMUS 75079 0.42371 0.00 1 0 0 0 0 192.909 0 0 0 0 0
and BTB 44.1 OUSE G0000002 0797 7403
domain- 9127
containing
protein 49
Nitric oxide Gucy1b ENZ IPI008568 Q8BXH3 D3Z022 ENSMUS 239134 0.42371 0.00 1 0 0 0 0 4133.55 0 0 0 0 0
sensitive 2 52.3 _MOUSE G0000002 0797 9123
guanylyl 1933
cyclase
beta2
subunit
Gucy1b2
(Guanylate
cyclase
soluble
subunit
beta-2)
Palladin Palld CS IPI008569 PALLD_ Q9ET54 ENSMUS 72333 0.42371 0.00 1 25.2611 0 0 0 0 0 0 0 0 0
26.1 MOUSE G0000005 0797 0692
8056
Chromodo Chd4 TF IPI008570 CHD4_M F6WR45 ENSMUS 107932 0.42371 0.00 3 0 249.462 0 0 0 0 0 0 0 0
main- 04.1 OUSE G0000006 0797 7778
helicase- 3870
DNA-
binding
protein 4
Uncharacte Adck4 ENZ IPI008570 ADCK4_ Q5XJH7 ENSMUS 0.42371 0.00 1 0 41.5391 0 0 0 0 0 0 0 0
rized aarF 25.1 MOUSE G0000000 0797 5544
domain- 3762
containing
protein
kinase 4
Intraflagell Ift140 TP IPI008572 Q2XQY6 Q6ZQ91 0.42371 0.00 3 0 0 1228.03 0 0 0 0 0 0 0
ar transport 42.1 _MOUSE 0797 2412
protein 140
homolog
Structural Smc4 CC IPI008574 SMC4_M Q3UR81 ENSMUS 70099 0.42371 0.00 1 117.724 0 0 0 0 0 0 0 0 0
maintenanc 14.1 OUSE G0000003 0797 9531
e of 4349
chromosom
es protein 4
40S Rps15a RIB IPI008574 RS15A_ F8WJ41/P ENSMUS 267019 0.42371 0.00 4 0 0 0 434.679 0 0 0 0 0 0
ribosomal 57.1/IPI00 MOUSE 62245 G0000000 0797 6711
protein 459875.4 8683
S15a
Fermitin Fermt2 CS IPI008574 FERM2_ A6X940/ ENSMUS 218952 0.42371 0.57 3 0 66.8060 0 0 0 0 0 0 0 37.9716
family 64.1/IPI00 MOUSE Q8CIB5 G0000003 0797 2482 4806
homolog 2 276222.1 7712
Cyclin- Cdk8 TF IPI008580 CDK8_M E0CYC4 ENSMUS 264064 0.42371 1000.00 1 0 0 0 0 0 0 0 0 311.848 0
dependent 41.1 OUSE G0000002 0797 7919
kinase 8 9635
Regulator Rgs12 MOD IPI008581 RGS12_ E9Q652 ENSMUS 71729 0.42371 1000.00 3 0 0 0 0 0 0 612.920 0 0 0
of G- 35.1 MOUSE G0000002 0797 2302
protein 9101
signaling

- 120 -
12
Coiled-coil Ccdc13 UK IPI008693 CC132_M Q8CI71 ENSMUS 73288 0.42371 0.00 1 0 0 172.857 0 0 0 0 0 0 0
domain- 2 59.1 OUSE G0000000 0797 9739
containing 1376
protein 132
Histone- Ehmt1 ENZ IPI008694 EHMT1_ Q5DW34 ENSMUS 77683 0.42371 0.00 2 0 0 238.797 0 0 0 0 0 0 0
lysine N- 68.1 MOUSE G0000003 0797 802
methyltrans 6893
ferase
EHMT1
Small Kcnn3 CNL IPI008743 KCNN3_ P58391 0.42371 1000.00 1 0 0 0 0 0 97.8562 0 0 0 0
conductanc 38.1 MOUSE 0797 8332
e calcium-
activated
potassium
channel
protein 3
Coiled-coil Ccdc88 UK IPI008745 CC88B_ Q4QRL3 ENSMUS 78317 0.42371 1000.00 2 0 0 0 0 0 166.863 0 0 0 0
domain- b 26.1 MOUSE G0000004 0797 2011
containing 7810
protein 88B
Protein Gm488 UK IPI008746 F6T1Q1_ F6T1Q1 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 149.075 0
Gm4884 4 87.1 MOUSE G0000004 0797 466
8312
Origin Orc1 CC IPI008746 ORC1_M Q8CFY7 ENSMUS 18392 0.42371 1000.00 2 0 0 0 0 0 0 0 238.759 0 0
recognition 95.1 OUSE G0000002 0797 9396
complex 8587
subunit 1
Protein Aste1 SIG IPI008748 ASTE1_ Q8BIR2 ENSMUS 66595 0.42371 1000.00 1 0 0 0 0 0 240.911 0 0 0 0
asteroid 53.1 MOUSE G0000003 0797 6464
homolog 1 2567
Neuroblast Nbas UK IPI008749 Q6GQV6 Q3UJX6 71169 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 135.396
oma- 07.2 _MOUSE 0797 313
amplified
sequence
Alcohol Adh6a ENZ IPI008751 E9Q5Z6_ E9Q4Y1 ENSMUS 69117 0.42371 0.00 1 0 0 21.8301 0 0 0 0 0 0 0
dehydrogen 55.2 MOUSE G0000005 0797 8368
ase 6A 3054
(Class V)
Storkhead- Stox2 UK IPI008754 STOX2_ Q499E5 ENSMUS 71069 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 382.494
box protein 60.2 MOUSE G0000003 0797 546
2 8143
Acetylcholi Colq SCA IPI008757 COLQ_M Q3KNA4 ENSMUS 382864 0.42371 0.00 1 59.7391 0 0 0 0 0 0 0 0 0
nesterase 08.2 OUSE G0000005 0797 8623
collagenic 7606
tail peptide
Alpha- Alpk3 ENZ IPI008758 ALPK3_ Q924C5 0.42371 0.00 1 0 0 355.969 0 0 0 0 0 0 0
protein 01.1 MOUSE 0797 3766
kinase 3
Jumonji Kdm3b TF IPI008759 B9EKS2_ B9EKS2 ENSMUS 277250 0.42371 0.00 4 466.584 0 0 0 0 0 0 0 0 0
domain 38.1 MOUSE G0000003 0797 688
containing 8773
1B (Lysine-
specific
demethylas
e 3B)

- 121 -
Calcium- Atp2c1 TP IPI008761 AT2C1_ Q3TTD2 ENSMUS 235574 0.42371 0.00 1 0 164.879 0 0 0 0 0 0 0 0
transporting 41.1 MOUSE G0000003 0797 4102
ATPase 2570
type 2C
member 1
Histone- Nsd1 TF IPI008764 NSD1_M G5E842 ENSMUS 0.42371 0.00 3 221.455 0 0 0 0 0 0 0 0 0
lysine N- 76.2 OUSE G0000002 0797 4694
methyltrans 1488
ferase, H3
lysine-36
and H4
lysine-20
specific
Oxysterol- Osbp TP IPI008765 OSBP1_ Q3B7Z2 ENSMUS 76303 0.42371 0.00 1 0 29.5577 0 0 0 0 0 0 0 0
binding 14.1 MOUSE G0000002 0797 9837
protein 1 4687
Latrophilin- Lphn2 RCP IPI008765 E9Q6C7_ E9Q6C7 ENSMUS 0.42371 0.00 2 0 0 0 1484.83 0 0 0 0 0 0
2 58.2 MOUSE G0000002 0797 9297
8184
HEAT Heatr5b UK IPI008771 HTR5B_ Q8C547 ENSMUS 320473 0.42371 1000.00 1 0 0 0 0 0 0 0 48.3178 0 0
repeat- 85.2 MOUSE G0000003 0797 5229
containing 9414
protein 5B
Aldo-keto Akr1c1 ENZ IPI008802 AK1CD_ D6RGB1 ENSMUS 27384 0.42371 0.00 1 0 0 205.176 0 0 0 0 0 0 0
reductase 3 62.1 MOUSE G0000002 0797 468
family 1 1213
member
C13
Exocrine Esp20 UK IPI008804 A8R0V3_ A8R0V3 0.42371 1000.00 1 0 0 0 0 0 42.8132 0 0 0 0
gland- 23.1 MOUSE 0797 399
secreting
peptide 20
60S Rpl26 RIB IPI008804 RL26_M B1ARA3 ENSMUS 19941 0.42371 0.00 3 0 0 0 239.883 0 0 0 0 0 0
ribosomal 92.1 OUSE G0000006 0797 7975
protein L26 0938
UPF0587 UK IPI008806 CA123_M D6REH4 ENSMUS 74098 0.42371 1000.00 1 0 0 0 0 0 0 0 0 338.598 0
protein 81.1 OUSE G0000002 0797 5857
C1orf123 8608
homolog
Protein Sval2 UK IPI008807 D3Z4E7_ D3Z4E7 ENSMUS 0.42371 0.00 1 249.062 0 0 0 0 0 0 0 0 0
Sval2 01.1 MOUSE G0000001 0797 2822
4104
40S Rps9 RIB IPI008807 RS9_MO F7CJS8 ENSMUS 76846 0.42371 0.00 1 0 0 0 101.870 0 0 0 0 0 0
ribosomal 50.1 USE G0000000 0797 6714
protein S9 6333
Protein Fam83e UK IPI008809 FA83E_M Q80XS7 ENSMUS 73813 0.42371 0.00 1 0 0 0 0 91.1972 0 0 0 0 0
FAM83E 35.1 OUSE G0000005 0797 1077
4161
Desmocolli Dsc2 CS IPI008809 DSC2_M F6RM34 ENSMUS 13506 0.42371 1000.00 1 0 0 0 0 0 0 0 0 24.7615 0
n-2 42.1 OUSE G0000002 0797 9949
4331
Heme Hmox2 ENZ IPI008810 HMOX2_ D3YX62 ENSMUS 15369 0.42371 0.00 1 0 0 0 232.422 0 0 0 0 0 0
oxygenase 90.1 MOUSE G0000000 0797 3517
2 4070
IQ domain- Iqce UK IPI008811 IQCE_M D3YXD4/ ENSMUS 74239 0.42371 1000.00 3 0 0 0 0 0 64.8334 0 0 132.271 0
containing 89.1/IPI00 OUSE Q6PCQ0 G0000003 0797 8217 5274

- 122 -
protein E 113135.2 6555
Tumor Tnfrsf8 RCP IPI008814 TNR8_M D6RHK4 ENSMUS 21941 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 27.3570
necrosis 65.1 OUSE G0000002 0797 0289
factor 8602
receptor
superfamily
member 8
Histone Hdac7 TF IPI008815 HDAC7_ E9PX62 ENSMUS 56233 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 449.652
deacetylase 27.1 MOUSE G0000002 0797 6338
7 2475
FGGY Fggy ENZ IPI008815 FGGY_M B7ZCH9 ENSMUS 75578 0.42371 1000.00 1 0 0 0 0 0 0 31.1967 0 0 0
carbohydrat 32.1 OUSE G0000002 0797 3361
e kinase 8573
domain-
containing
protein
Protein Fam160 UK IPI008815 F16A1_M E9PX40 ENSMUS 229488 0.42371 0.00 1 551.581 0 0 0 0 0 0 0 0 0
FAM160A a1 75.2 OUSE G0000005 0797 5703
1 1000
Uncharacte UK IPI008815 CB080_M D3YUK5 ENSMUS 98303 0.42371 0.00 1 0 0 0 0 598.680 0 0 0 0 0
rized 79.1 OUSE G0000004 0797 3069
protein 4816
C2orf80
homolog
Pre-mRNA Pcf11 TF IPI008817 Q69ZY3_ Q6PCW0 74737 0.42371 1000.00 2 0 0 0 0 0 0 0 0 1842.52 0
cleavage 21.1 MOUSE 0797 2398
complex 2
protein
Pcf11
DNA- Ighmbp TF IPI008818 SMBP2_ D3Z5P5 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 73.3287 0 0 0
binding 2 97.1 MOUSE G0000002 0797 7219
protein 4831
SMUBP-2
BTB/POZ Btbd10 UK IPI008819 BTBDA_ D6RDQ7 ENSMUS 68815 0.42371 0.00 1 0 0 313.341 0 0 0 0 0 0 0
domain- 89.1 MOUSE G0000003 0797 8729
containing 8187
protein 10
Transducin- Tle6 DEV IPI008820 TLE6_M D3YV26 ENSMUS 114606 0.42371 1000.00 1 0 0 0 0 0 0 0 79.0827 0 0
like 07.3 OUSE G0000003 0797 8879
enhancer 4758
protein 6
Rho-related Rhoj CS IPI008821 RHOJ_M F2Z463 ENSMUS 80837 0.42371 1000.00 2 0 0 0 0 0 61.2477 0 0 0 0
GTP- 13.1 OUSE G0000004 0797 2656
binding 6768
protein
RhoJ
Pleckstrin Plekhg5 SIG IPI008821 PKHG5_ A2A8B6 ENSMUS 269608 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 501.174
homology 87.1 MOUSE G0000003 0797 1996
domain- 9713
containing
family G
member 5
Hermansky Hps5 TP IPI008854 HPS5_M F6YT95 ENSMUS 246694 0.42371 1000.00 1 0 0 0 0 0 73.5326 0 0 0 0
-Pudlak 34.1 OUSE G0000001 0797 7271
syndrome 5 4418
protein

- 123 -
homolog
Protein Spire2 CS IPI008854 SPIR2_M Q8K1S6 ENSMUS 234857 0.42371 0.00 1 0 0 86.6300 0 0 0 0 0 0 0
spire 99.1 OUSE G0000001 0797 2361
homolog 2 0154
Putative Slc38a1 TP IPI008857 S38AA_ Q5I012 ENSMUS 72055 0.42371 1000.00 1 0 0 0 0 0 0 40.8475 0 0 0
sodium- 0 60.1 MOUSE G0000006 0797 0685
coupled 1306
neutral
amino acid
transporter
10
Afadin Mllt4 CS IPI008859 AFAD_M Q3TLN8 ENSMUS 17356 0.42371 1000.00 1 0 0 0 0 0 0 0 52.3228 0 0
06.1 OUSE G0000006 0797 2693
8036
Adenosine Ficd ENZ IPI008859 FICD_M Q8BIX9 ENSMUS 231630 0.42371 0.00 1 0 0 251.030 0 0 0 0 0 0 0
monophosp 12.1 OUSE G0000005 0797 6743
hate-protein 3334
transferase
FICD
Protein sel- Sel1l3 TM IPI008860 SE1L3_M Q80TS8 ENSMUS 231238 0.42371 0.00 1 0 0 205.624 0 0 0 0 0 0 0
1 homolog 35.2 OUSE G0000002 0797 9651
3 9189
Uncharacte UK IPI008861 CG063_M Q8BH53 ENSMUS 207686 0.42371 1000.00 1 0 0 0 0 0 0 0 44.4210 0 0
rized 05.1 OUSE G0000004 0797 8519
protein 0473
C7orf63
homolog
Alpha- Add1 CS IPI008863 ADDA_M F6RDR0 ENSMUS 11518 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 104.798
adducin 59.1 OUSE G0000002 0797 1301
9106
V-alpha RCP IPI008863 TVA3_M Q5R1H1 0.42371 1000.00 1 0 0 0 0 0 0 37.4551 0 0 0
F3.6. (T- 85.1 OUSE 0797 7659
cell
receptor
alpha chain
V region
CTL-F3)
UDP-N- Uap1l1 ENZ IPI008892 UAP1L_ Q3TW96 ENSMUS 227620 0.42371 1000.00 1 0 0 0 0 0 0 0 0 82.6246 0
acetylhexos 48.1 MOUSE G0000002 0797 4622
amine 6956
pyrophosph
orylase-like
protein 1
Cytoskeleto Ckap2l CS IPI008892 CKP2L_ Q7TS74 ENSMUS 70466 0.42371 0.00 1 0 0 19.9755 0 0 0 0 0 0 0
n- 73.1 MOUSE G0000004 0797 3212
associated 8327
protein 2-
like;
Protocadher Fat4 CS IPI008893 FAT4_M Q2PZL6 ENSMUS 329628 0.42371 0.00 1 0 0 0 295.975 0 0 0 0 0 0
in Fat 4 10.3 OUSE G0000004 0797 234
6743
5- Azi1 DEV IPI008899 AZI1_MO B1AXI9 ENSMUS 12009 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 204.807
azacytidine 61.2 USE G0000003 0797 5795
-induced 9781
protein 1
NACHT, Nlrp9a UK IPI008947 NAL9A_ D3YYQ3 ENSMUS 233001 0.42371 0.00 1 0 0 0 127.206 0 0 0 0 0 0

- 124 -
LRR and 51.1 MOUSE G0000005 0797 3887
PYD 4102
domains-
containing
protein 9A
Serine/thre Ick ENZ IPI008949 ICK_MO Q3UZZ3 ENSMUS 56542 0.42371 1000.00 1 0 0 0 0 0 0 50.4450 0 0 0
onine- 18.1 USE G0000000 0797 2396
protein 9828
kinase ICK
Glutamate Gria3 CNL IPI008950 GRIA3_ Q3UY17 ENSMUS 53623 0.42371 0.00 1 185.543 0 0 0 0 0 0 0 0 0
receptor 3 35.1 MOUSE G0000000 0797 1795
1986
Rap Rapgef2 MOD IPI008952 RPGF2_ Q8CHG7 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 9.89868 0 0 0
guanine 95.1 MOUSE G0000006 0797 1998
nucleotide 2232
exchange
factor 2
Double- Mre11a CC IPI008953 MRE11_ F6RX99 ENSMUS 17535 0.42371 1000.00 1 0 0 0 0 0 58.4862 0 0 0 0
strand 71.1 MOUSE G0000003 0797 2198
break repair 1928
protein
MRE11A
Potassium Kcnu1 CNL IPI008955 KCNU1_ D3Z073 ENSMUS 16532 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 32.2565
channel 13.1 MOUSE G0000003 0797 9069
subfamily 1576
U member
1
T-cell Cd8a MHC IPI008965 CD8A_M Q61816 ENSMUS 12525 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 60.0598
surface 68.1 OUSE G0000005 0797 962
glycoprotei 3977
n CD8
alpha chain
Protein Gm175 UK IPI008966 B2RZI1_ B2RZI1 ENSMUS 0.42371 0.47 4 196.621 0 0 0 92.1008 0 67.9614 0 0 0
Gm17503 03 48.2/IPI00 MOUSE G0000009 0797 3239 1598 5635
985781.1/ 1821
IPI009892
48.1
Protein Erbb2ip SCA IPI008966 LAP2_M B2RUJ2 ENSMUS 59079 0.42371 1000.00 1 0 0 0 0 0 1925.98 0 0 0 0
LAP2 81.1 OUSE G0000002 0797 8212
1709
Tudor Tdrd6 DEV IPI008967 TDRD6_ B2RRD1 210510 0.42371 1000.00 2 0 0 0 0 0 165.289 0 0 0 0
domain- 21.2 MOUSE 0797 5123
containing
protein 6
Histone- Setdb2 CC IPI009111 SETB2_ B4XVP0 ENSMUS 239122 0.42371 0.00 1 0 0 200.965 0 0 0 0 0 0 0
lysine N- 21.2 MOUSE G0000007 0797 9466
methyltrans 1350
ferase
SETDB2
Receptor- Ptprs RCP IPI009155 PTPRS_ B0V2N1 ENSMUS 19280 0.42371 1000.00 1 0 0 0 0 0 0 0 258.718 0 0
type 12.1 MOUSE G0000001 0797 7189
tyrosine- 3236
protein
phosphatas
eS
Rho Arhgef4 MOD IPI009180 ARHG4_ E9PYK8 ENSMUS 226970 0.42371 1000.00 1 0 0 0 0 0 105.232 0 0 0 0

- 125 -
guanine 40.1 MOUSE G0000003 0797 9095
nucleotide 7509
exchange
factor 4
E3 Rnf6 MOD IPI009180 RNF6_M E0CYZ9 ENSMUS 74132 0.42371 1000.00 1 0 0 0 0 0 0 106.813 0 0 0
ubiquitin- 56.1 OUSE G0000002 0797 2677
protein 9634
ligase
RNF6
Prostagland Ptgr2 ENZ IPI009182 PTGR2_ Q3TXN1 ENSMUS 77219 0.42371 0.00 1 19.3902 0 0 0 0 0 0 0 0 0
in reductase 01.1 MOUSE G0000007 0797 2204
2 2946
Arfaptin-1 Arfip1 TP IPI009182 G5E8V9_ E9QAY5 ENSMUS 99889 0.42371 0.00 1 0 137.760 0 0 0 0 0 0 0 0
69.1 MOUSE G0000007 0797 3968
4513
N-myc- Nmi TF IPI009184 NMI_MO B7ZD13 ENSMUS 64685 0.42371 0.00 1 0 51.4282 0 0 0 0 0 0 0 0
interactor 03.2 USE G0000002 0797 3326
6946
Pleckstrin Phldb1 UK IPI009185 PHLB1_ F7CB18 ENSMUS 102693 0.42371 0.00 1 0 0 0 287.421 0 0 0 0 0 0
homology- 71.1 MOUSE G0000004 0797 4233
like domain 8537
family B
member 1
JmjC Jmjd7 UK IPI009187 JMJD7_M F6VZY1 ENSMUS 433466 0.42371 0.00 2 0 0 104.271 0 0 0 0 0 0 0
domain- 28.1 OUSE G0000003 0797 3532
containing 3852
protein 7
Rap Rapgef3 MOD IPI009190 RPGF3_ E9Q2E5 ENSMUS 223864 0.42371 1000.00 1 0 0 0 0 0 0 174.518 0 0 0
guanine 59.3 MOUSE G0000002 0797 321
nucleotide 2469
exchange
factor 3
Ataxin-7- Atxn7l1 UK IPI009192 E9Q539_ B2RW07 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 190.087 0 0 0
like protein 15.1 MOUSE G0000002 0797 8141
1 0564
Protein 4.1 Epb41 CS IPI009216 41_MOU B6ZHC3/ ENSMUS 269587 0.42371 16.89 16 42.0900 0 0 0 0 539.563 882.575 0 0 0
39.1/IPI00 SE Q3UH12/ G0000002 0797 9282 869 1432
654038.3/ A2A842/P 8906
IPI006480 48193
08.1/IPI00
395157.2
LIM Lmo7 UK IPI009229 B7ZN52_ B7ZN52 ENSMUS 0.42371 0.00 2 107.459 0 0 0 0 0 0 0 0 0
domain 55.1 MOUSE G0000003 0797 8204
only 3060
protein 7,
F-box only
protein 20
Regulator Rgs1 MOD IPI009236 RGS1_M Q9JL25 ENSMUS 50778 0.42371 0.00 1 0 0 0 0 210.909 0 0 0 0 0
of G- 57.2 OUSE G0000002 0797 8739
protein 6358
signaling 1
Protein Gm166 UK IPI009236 E9Q963_ E9Q963 ENSMUS 381544 0.42371 1000.00 1 0 0 0 0 0 40.9329 0 0 0 0
Gm1661 1 64.1 MOUSE G0000006 0797 3102
(Uncharact 0268
erized
protein

- 126 -
C1orf228)
Transcripti Tcf20 TF IPI009236 TCF20_M Q66JM6 0.42371 1000.00 2 0 0 0 0 0 0 123.779 0 0 0
on factor 20 68.1 OUSE 0797 9802
Cohesin Stag1 CC IPI009281 STAG1_ F8WHU7 ENSMUS 20842 0.42371 0.00 2 370.714 0 0 0 0 0 0 0 0 0
subunit SA- 27.1 MOUSE G0000003 0797 5067
1 7286
Protein Fam78b UK IPI009283 FA78B_ F6ZXE6 ENSMUS 226610 0.42371 1000.00 1 0 0 0 0 0 0 104.481 0 0 0
FAM78B 51.1 MOUSE G0000006 0797 564
0568
RNA- Rbm25 TF IPI009285 RBM25_ B2RY56 ENSMUS 67039 0.42371 0.00 1 0 0 0 65.9382 0 0 0 0 0 0
binding 41.1 MOUSE G0000001 0797 5446
protein 25 0608
Ring finger Rnf26 TM IPI009285 RNF26_ Q8BUH7 ENSMUS 213211 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 60.0598
protein 26 80.1 MOUSE G0000005 0797 962
3128
Probable Rbm18 TF IPI009297 RBM18_ Q9CR83 ENSMUS 67889 0.42371 1000.00 1 0 0 0 0 0 0 44.5802 0 0 0
RNA- 94.1 MOUSE G0000002 0797 3253
binding 6889
protein 18
Eukaryotic Eif4a1 TF IPI009297 IF4A1_M Q3TLL6 ENSMUS 13681 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 94.3143
initiation 97.1 OUSE G0000005 0797 7153
factor 4A-I 9796
Ig kappa IGG IPI009307 KV2A6_ P01630 0.42371 1000.00 1 0 0 0 0 0 54.9417 0 0 0 0
chain V-II 57.1 MOUSE 0797 4122
region
7S34.1
Hamartin Tsc1 MOD IPI009434 TSC1_M Q9EP53 ENSMUS 64930 0.42371 1000.00 1 0 0 0 0 0 0 38.3652 0 0 0
54.2 OUSE G0000002 0797 2689
6812
Tight Tjp1 CS IPI009440 ZO1_MO B9EHJ3 ENSMUS 21872 0.42371 1000.00 1 0 0 0 0 0 80.5296 0 0 0 0
junction 62.1 USE G0000003 0797 0532
protein ZO- 0516
1
Mediator of Med16 TF IPI009441 MED16_ Q6PGF3 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 25.4735 0 0 0 0
RNA 27.1 MOUSE G0000001 0797 1701
polymerase 3833
II
transcriptio
n subunit
16
Tetratricop Ttc28 UK IPI009447 TTC28_M Q80XJ3 209683 0.42371 1000.00 2 0 0 0 0 0 454.191 0 0 0 0
eptide 24.1 OUSE 0797 235
repeat
protein 28
Dynein Dnahc6 CS IPI009447 E9Q0B6_ Q8BZ42 ENSMUS 330355 0.42371 0.00 1 0 0 2451.83 0 0 0 0 0 0 0
heavy chain 64.1 MOUSE G0000005 0797 8373
6, 2861
axonemal
Schlafen UK IPI009476 P0C7P3 ENSG000 0.42371 1000.00 2 0 0 0 0 0 0 736.503 0 0 0
family 21.1 00236320 0797 4641
member 14
Sperm Smok2b ENZ IPI009546 SMK2B_ Q9QYZ3 ENSMUS 236574 0.42371 0.00 1 63.6739 0 0 0 0 0 0 0 0 0
motility 44.1 MOUSE G0000007 0797 6439
kinase 2B 3457
Histone- Prdm9 CC IPI009551 PRDM9_ D2K7E0 ENSMUS 0.42371 0.00 1 111.655 0 0 0 0 0 0 0 0 0
lysine N- 44.1 MOUSE G0000005 0797 4283

- 127 -
methyltrans 1977
ferase
PRDM9
GTP- Rem2 SIG IPI009553 REM2_M Q8VEL9 ENSMUS 140743 0.42371 1000.00 1 0 0 0 0 0 0 76.5727 0 0 0
binding 87.2 OUSE G0000002 0797 3403
protein 2176
REM 2
T-box Tbx2 TF IPI009567 TBX2_M Q60707 ENSMUS 21385 0.42371 0.00 1 168.622 0 0 0 0 0 0 0 0 0
transcriptio 82.2 OUSE G0000000 0797 62
n factor 0093
TBX2
Protein bromi DEV IPI009569 BROMI_ Q3URV1 ENSMUS 544696 0.42371 1000.00 1 0 0 0 0 0 26.2560 0 0 0 0
broad- 03.1 MOUSE G0000003 0797 8337
minded 8122
Putative Gm117 UK IPI009569 Q8R1L2_ Q8R1L2 0.42371 0.00 1 0 0 0 324.139 0 0 0 0 0 0
uncharacter 67 52.1 MOUSE 0797 1738
ized protein
Gm11767
Tyrosyl- Tdp1 ENZ IPI009570 TYDP1_ D3Z075 ENSMUS 0.42371 0.00 1 0 0 81.8567 0 0 0 0 0 0 0
DNA 92.1 MOUSE G0000002 0797 9738
phosphodie 1177
sterase 1
6- Pfkfb3 ENZ IPI009683 A7UAK4 A7UAK4 ENSMUS 170768 0.42371 0.00 2 451.964 0 0 0 0 0 0 0 0 0
phosphofru 98.1 _MOUSE G0000002 0797 0411
cto-2- 6773
kinase/fruct
ose-2,6-
biphosphata
se 3
isoform 1
THO BC0055 TF IPI009688 E9Q5E2_ Q3UYT9/ ENSMUS 10004216 0.42371 0.15 2 0 0 0 229.098 0 33.5266 0 0 0 0
complex 61 65.1/IPI00 MOUSE E9Q5E2 G0000007 5 0797 4113 2918
subunit 2 348717.6 9065
Ig gamma- Igh-1a IGG IPI009688 GCAM_ Q5R3X4 0.42371 0.00 1 0 50.8051 0 0 0 0 0 0 0 0
2A chain C 85.1 MOUSE 0797 4535
region,
membrane-
bound form
Serine/thre Ppp4r1 MOD IPI009698 PP4R1_M Q8K2V1 ENSMUS 70351 0.42371 0.00 1 0 0 138.481 0 0 0 0 0 0 0
onine- 24.1 OUSE G0000006 0797 3441
protein 1950
phosphatas
e4
regulatory
subunit 1
Beta- Actr1b CS IPI009698 ACTY_M E0CZD4 ENSMUS 226977 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 66.4806
centractin 47.1 OUSE G0000003 0797 6933
7351
RING Rnf43 MOD IPI009699 RNF43_ E9PWJ5 ENSMUS 207742 0.42371 1000.00 2 0 0 0 0 0 0 75.5324 0 0 0
finger 18.1 MOUSE G0000003 0797 3061
protein 43 4177
Filamin A- Filip1l MOD IPI009700 FIL1L_M E0CYM1/ ENSMUS 0.42371 0.60 5 0 0 265.500 0 0 0 0 158.738 0 0
interacting 23.1/IPI00 OUSE Q6P6L0 G0000004 0797 7804 5943
protein 1 876144.2 3336
WD repeat- Wdr96 UK IPI009701 E9Q651_ E9Q651 ENSMUS 0.42371 1000.00 3 0 0 0 0 0 220.098 0 0 0 0
containing 78.1 MOUSE G0000004 0797 9979

- 128 -
protein 96 4948
Uncharacte Kiaa132 UK IPI009703 K1328_M E0CZ24 ENSMUS 225289 0.42371 0.00 1 0 0 158.891 0 0 0 0 0 0 0
rized 8 33.1 OUSE G0000003 0797 0413
protein 3632
KIAA1328
Vomeronas Vmn2r2 RCP IPI009705 V2R26_M Q3UXB9 ENSMUS 56552 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 153.925
al type-2 6 75.1 OUSE G0000003 0797 2647
receptor 26 0141
Exocyst Exoc3l2 UK IPI009712 D3YUP5_ D3YUP5 ENSMUS 0.42371 0.00 2 0 0 111.645 0 0 0 0 0 0 0
complex 93.1 MOUSE G0000001 0797 5058
component 1263
3-like
protein 2
40S Rps23 RIB IPI009729 RS23_M Q9CSN9 ENSMUS 66475 0.42371 0.00 2 0 0 0 71.1460 0 0 0 0 0 0
ribosomal 20.1 OUSE G0000004 0797 4652
protein S23 9517
Neuronal Npas3 TF IPI009746 NPAS3_ Q0IJ77 ENSMUS 0.42371 0.00 1 84.8482 0 0 0 0 0 0 0 0 0
PAS 15.1 MOUSE G0000002 0797 1489
domain- 1010
containing
protein 3
Exocyst Exoc3l4 UK IPI009746 EX3L4_ Q3U393 ENSMUS 74190 0.42371 1000.00 1 0 0 0 0 0 0 0 0 42.0578 0
complex 76.1 MOUSE G0000002 0797 6552
component 1280
3-like
protein 4
Poly(rC)- Pcbp3 RIB IPI009746 PCBP3_ E9Q7D8 ENSMUS 59093 0.42371 0.00 1 0 0 0 0 40.7731 0 0 0 0 0
binding 90.1 MOUSE G0000000 0797 5298
protein 3 1120
Ephrin Ephb3 RCP IPI009747 EPHB3_ F8WHG4 ENSMUS 13845 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 451.301
type-B 64.1 MOUSE G0000000 0797 0195
receptor 3 5958
NHS-like Nhsl2 UK IPI009748 NHSL2_ B1AXH1 ENSMUS 0.42371 0.00 2 222.905 0 0 0 0 0 0 0 0 0
protein 2 42.1 MOUSE G0000007 0797 8246
9481
Pleckstrin Plekha6 UK IPI009749 PKHA6_ F6WVT1 ENSMUS 240753 0.42371 1000.00 1 0 0 0 0 0 0 13.6792 0 0 0
homology 35.1 MOUSE G0000004 0797 0353
domain- 1757
containing
family A
member 6
WW Wbp11 TF IPI009749 WBP11_ Q3U521 ENSMUS 60321 0.42371 0.00 1 0 0 66.5275 0 0 0 0 0 0 0
domain- 83.1 MOUSE G0000003 0797 034
binding 0216
protein 11
Igh protein Gm168 IGG IPI009750 Q05DT8_ Q05DT8 0.42371 0.00 3 0 0 0 0 207.445 0 0 0 0 0
Gm16844 44 17.1 MOUSE 0797 9465
UV Rad23b MOD IPI009751 RD23B_ Q3TJ52 ENSMUS 19359 0.42371 0.00 1 0 0 38.1441 0 0 0 0 0 0 0
excision 07.1 MOUSE G0000002 0797 6148
repair 8426
protein
RAD23
homolog B
rRNA- Fcf1 RIB IPI009855 FCF1_M E9QA58 ENSMUS 73736 0.42371 1000.00 1 0 0 0 0 0 93.4032 0 0 0 0
processing 41.1 OUSE G0000007 0797 1092
protein 0308|ENS

- 129 -
FCF1 MUSG00
homolog 00002124
3
1,4-alpha- Gbe1 ENZ IPI009855 GLGB_M Q8C7E6 ENSMUS 74185 0.42371 0.00 3 657.068 0 0 0 0 0 0 0 0 0
glucan- 85.1 OUSE G0000002 0797 0508
branching 2707
enzyme
Septin-7 Sep-07 CC IPI009856 SEPT7_M Q5DTS3 ENSMUS 235072 0.42371 0.00 1 30.7275 0 0 0 0 0 0 0 0 0
15.2 OUSE G0000000 0797 4124
1833
Prothymosi Ptma MOD IPI009856 PTMA_M P26350 ENSMUS 19231 0.42371 1000.00 1 0 0 0 0 0 0 0 25.0198 0 0
n alpha 30.1 OUSE G0000002 0797 5616
6238
UK IPI009856 0.42371 0.00 1 0 172.553 0 0 0 0 0 0 0 0
60.1 0797 3595
Protein Fam184 UK IPI009857 E9PW83_ F6RSY8 ENSMUS 75906 0.42371 0.00 1 56.7869 0 0 0 0 0 0 0 0 0
FAM184A a 77.1 MOUSE G0000001 0797 8209
9856
SHC- Shc3 SIG IPI009858 SHC3_M Q3ZAX3 ENSMUS 20418 0.42371 1000.00 1 0 0 0 0 0 928.157 0 0 0 0
transformin 90.1 OUSE G0000002 0797 0846
g protein 3 1448
Tetratricop Ttc21b CS IPI009862 TT21B_M Q3UGQ4 ENSMUS 73668 0.42371 0.00 1 0 0 0 367.340 0 0 0 0 0 0
eptide 44.1 OUSE G0000003 0797 6038
repeat 4848
protein 21B
MKIAA03 Pdzd2 SCA IPI009864 Q80U45_ E9Q2C5 ENSMUS 0.42371 0.00 1 21.5189 0 0 0 0 0 0 0 0 0
00 protein 04.1 MOUSE G0000002 0797 6352
(PDZ 2197
domain-
containing
protein 2)
Niemann- Npc1 TP IPI009864 NPC1_M Q3U2B2 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 97.1709 0
Pick C1 19.1 OUSE G0000002 0797 6387
protein 4413
Msx2- Spen TF IPI009866 MINT_M E9Q807 ENSMUS 56381 0.42371 0.00 1 0 33.4005 0 0 0 0 0 0 0 0
interacting 50.1 OUSE G0000004 0797 6078
protein 0761
KN motif Kank1 UK IPI009866 Q6AXG6 Q8BUK3 107351 0.42371 1000.00 2 0 0 0 0 0 0 169.776 0 0 0
and ankyrin 89.1 _MOUSE 0797 3731
repeat
domain-
containing
protein 1
Uncharacte Gm366 UK IPI009867 E9PV29_ E9PV29 ENSMUS 0.42371 0.00 1 0 0 0 1217.92 0 0 0 0 0 0
rized 7 45.1 MOUSE G0000009 0797 8167
protein 0691
Gm3667
Ran Rangap MOD IPI009868 RAGP1_ E9Q2J7 ENSMUS 19387 0.42371 0.00 1 0 269.731 0 0 0 0 0 0 0 0
GTPase- 1 15.1 MOUSE G0000002 0797 4773
activating 2391
protein 1
SH3 and Shank3 SCA IPI009868 SHAN3_ Q4ACU6 ENSMUS 58234 0.42371 0.00 1 0 0 238.064 0 0 0 0 0 0 0
multiple 26.1 MOUSE G0000002 0797 7785
ankyrin 2623
repeat
domains

- 130 -
protein 3
60S Rpl29 RIB IPI009868 RL29_M P47915 ENSMUS 19944 0.42371 1.39 2 0 0 0 67.0414 0 0 0 0 0 93.3312
ribosomal 29.1/IPI00 OUSE G0000004 0797 7913 2604
protein 987074.1 8758
L29-like
Protein Cux1 TP IPI009868 CASP_M P70381 13047 0.42371 0.00 1 0 0 0 103.001 0 0 0 0 0 0
CASP 32.1 OUSE 0797 2033
Proteasome Psma1 ENZ IPI009868 PSA1_M E9Q3B7 ENSMUS 26440 0.42371 0.00 2 59.7679 0 0 0 0 0 0 0 0 0
subunit 45.1 OUSE G0000003 0797 7775
alpha type- 0751
1
Liprin- Ppfia4 MOD IPI009869 B8QI36_ E9Q4K4 ENSMUS 68507 0.42371 0.00 2 1206.26 0 0 0 0 0 0 0 0 0
alpha 4 67.1 MOUSE G0000002 0797 1325
6458
UK IPI009871 0.42371 0.00 1 0 0 0 500.032 0 0 0 0 0 0
62.1 0797 7563
Uncharacte UK IPI009872 G3MZG0 ENSBTA 0.42371 0.00 4 0 548.572 0 0 0 0 0 0 0 0
rized 44.1 G0000002 0797 5055
protein 0802
Rab11 Rab11fi TP IPI009872 RFIP5_M F6YCY1 ENSMUS 52055 0.42371 0.00 1 0 0 17.4695 0 0 0 0 0 0 0
family- p5 90.2 OUSE G0000005 0797 3648
interacting 1343
protein 5
Cadherin- Cdh11 CS IPI009873 CAD11_ P55288 ENSMUS 12552 0.42371 0.00 1 0 0 35.9858 0 0 0 0 0 0 0
11 47.1 MOUSE G0000003 0797 037
1673
Zinc finger Znf521 TF IPI009874 ZN521_M E9PWM6 ENSMUS 225207 0.42371 1000.00 1 0 0 0 0 0 0 0 0 83.0508 0
protein 521 55.1 OUSE G0000002 0797 9501
4420
Retrovirus- Pol TF IPI009874 POL2_M F6U8B9 ENSMUS 0.42371 0.00 1 0 0 0 0 1443.18 0 0 0 0 0
related Pol 95.1 OUSE G0000009 0797 3088
polyprotein 0353|ENS
LINE-1 MUSG00
00009038
4
Arf-GAP Arap3 MOD IPI009877 ARAP3_ E9Q0K7 ENSMUS 106952 0.42371 0.00 1 42.6820 0 0 0 0 0 0 0 0 0
with Rho- 21.2 MOUSE G0000002 0797 2043
GAP 4451
domain,
ANK repeat
and PH
domain-
containing
protein 3
Coiled-coil UK IPI009879 G3HZZ7 0.42371 1000.00 1 0 0 0 0 0 0 122.039 0 0 0
domain- 01.1 0797 7431
containing
protein 155
Tyrosine- Lyn ENZ IPI009879 LYN_MO P25911 ENSMUS 17096 0.42371 0.00 1 0 0 0 0 169.527 0 0 0 0 0
protein 65.1 USE G0000004 0797 4831
kinase Lyn 2228
Fucose-1- Fpgt ENZ IPI009879 Q2TB53_ Q8C1A2 ENSMUS 75540 0.42371 1000.00 1 0 0 0 0 0 0 107.957 0 0 0
phosphate 74.1 MOUSE G0000005 0797 6093
guanylyltra 3870
nsferase
FYVE, Fgd5 MOD IPI009880 FGD5_M Q80UZ0 232237 0.42371 0.00 1 11.0522 0 0 0 0 0 0 0 0 0

- 131 -
RhoGEF 89.2 OUSE 0797 3517
and PH
domain-
containing
protein 5
Protein Gm671 UK IPI009882 E9Q021_ E9Q021 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 55.7074
Gm6713 3 39.1 MOUSE G0000009 0797 172
0414
Protein Ahnak2 DEV IPI009883 E9PYB0_ E9PYB0 ENSMUS 0.42371 0.00 2 128.757 0 0 0 0 0 0 0 0 0
AHNAK2 75.1 MOUSE G0000007 0797 617
(Neuroblast 2812
differentiati
on-
associated
protein
AHNAK2)
Cell Cdc5l TF IPI009884 CDC5L_ E9Q5F8 ENSMUS 71702 0.42371 1000.00 1 0 0 0 0 0 0 1127.52 0 0 0
division 98.1 MOUSE G0000007 0797 957
cycle 5-like 4684|ENS
protein MUSG00
00002393
2
60S Rpl5 RIB IPI009885 RL5_MO P47962 ENSMUS 10050367 0.42371 0.00 1 51.4257 0 0 0 0 0 0 0 0 0
ribosomal 75.1 USE G0000005 0 0797 553
protein L5- 8558
like
Eukaryotic Eif4a3 TF IPI009886 IF4A3_M Q91VC3 ENSMUS 192170 0.42371 1000.00 2 0 0 0 0 0 0 0 122.933 0 0
initiation 98.1 OUSE G0000002 0797 2932
factor 4A- 5580
III
Protein Gm493 UK IPI009887 E9PZH1_ E9PZH1 ENSMUS 0.42371 0.00 1 0 0 0 0 131.185 0 0 0 0 0
Gm4934 4 29.1 MOUSE G0000009 0797 214
1311
Protein Slfn3 UK IPI009887 E9PYG4_ E9PYG4 ENSMUS 0.42371 0.00 1 0 0 0 0 2202.51 0 0 0 0 0
Slfn3 55.2 MOUSE G0000001 0797 4879
(Schlafen 8986
3)
Sarcoplasm Atp2a3 TP IPI009887 AT2A3_ Q64518 ENSMUS 53313 0.42371 1000.00 4 0 0 0 0 0 0 0 0 0 589.162
ic/endoplas 97.2 MOUSE G0000002 0797 9744
mic 0788
reticulum
calcium
ATPase 3
UDP- Uggt2 ENZ IPI009888 Q2NLC7_ Q2NLC7 ENSG000 0.42371 1000.00 1 0 0 0 0 0 83.6509 0 0 0 0
glucose:gly 54.1 MOUSE 00102595 0797 9765
coprotein
glucosyltra
nsferase 2
60S Rpl35a RIB IPI009888 RL35A_ O55142 ENSMUS 10004603 0.42371 1000.00 1 0 0 0 0 0 0 21.0548 0 0 0
ribosomal 76.1 MOUSE G0000006 4 0797 2447
protein 0636
L35a-like
Helicase Srcap TF IPI009888 Q3U4M6 E9Q9V7 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 111.577 0 0 0
SRCAP 84.1 _MOUSE G0000005 0797 0015
3877
Uncharacte UK IPI009889 CL055_M Q8C6S9 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 20.4640 0 0 0

- 132 -
rized 77.1 OUSE G0000002 0797 5892
protein 0014
C12orf55
homolog
Y-linked UK IPI009891 B6ZB76_ B6ZB76 0.42371 0.00 6 0 0 1108.04 0 0 0 0 0 0 0
testis- 64.1/IPI00 MOUSE 0797 6933
specific 990696.1
protein
Nuclear Nup98 TP IPI009892 E9PYP6_ E9PZU1 ENSMUS 0.42371 0.00 1 0 0 0 0 743.354 0 0 0 0 0
pore 34.1 MOUSE G0000006 0797 7194
complex 3550
protein
Nup98-
Nup96
Protein Gm362 UK IPI009893 D3YU32_ D3YU32 ENSMUS 637093 0.42371 1000.00 2 0 0 0 0 0 0 58.6045 0 0 0
Gm362 37.1 MOUSE G0000007 0797 7894
8320
snRNA- Snapc4 TF IPI009893 SNPC4_ Q8BP86 ENSMUS 227644 0.42371 1000.00 1 0 0 0 0 0 0 29.4254 0 0 0
activating 72.1 MOUSE G0000003 0797 2454
protein 6281
complex
subunit 4
Transient Trpm3 CNL IPI009893 B2RUS0_ Q8BIH6 ENSMUS 226025 0.42371 0.00 2 252.582 0 0 0 0 0 0 0 0 0
receptor 87.1 MOUSE G0000005 0797 1051
potential 2387
cation
channel
subfamily
M member
3
Synaptojani Synj1 ENZ IPI009895 SYNJ1_M F7BQW7 ENSMUS 0.42371 0.00 1 0 0 0 135.600 0 0 0 0 0 0
n-1 29.1 OUSE G0000002 0797 563
2973
Ras Rasa1 MOD IPI009895 E9PYG6_ Q91YX7 ENSMUS 218397 0.42371 1000.00 1 0 0 0 0 0 139.988 0 0 0 0
GTPase- 77.1 MOUSE G0000002 0797 6773
activating 1549
protein 1
SAM Samhd1 SIG IPI009895 SAMH1_ Q6ZQM3 ENSMUS 56045 0.42371 0.00 1 0 0 0 1282.94 0 0 0 0 0 0
domain and 99.1 MOUSE G0000002 0797 6238
HD 7639
domain-
containing
protein 1
Tensin-1 Tns1 CS IPI009897 E9Q0S6_ Q7TSV1 ENSMUS 21961 0.42371 0.00 5 173.375 0 0 0 0 0 0 0 0 0
27.1 MOUSE G0000005 0797 0818
5322
MAM Mdga1 DEV IPI009898 MDGA1_ E9Q6S8 ENSMUS 0.42371 0.00 1 48.2394 0 0 0 0 0 0 0 0 0
domain- 05.1 MOUSE G0000004 0797 864
containing 3557
glycosylph
osphatidyli
nositol
anchor
protein 1
Alpha34- Gm325 UK IPI009898 E9PUT9_ A6NAV1 ENSMUS 0.42371 1000.00 3 0 0 0 0 0 0 0 0 0 1787.28
takusan 2 30.1 MOUSE G0000009 0797 4777
2016

- 133 -
Bifunctiona Dak ENZ IPI009898 DHAK_M Q3UTZ4 ENSMUS 225913 0.42371 1000.00 1 0 0 0 0 0 25.4735 0 0 0 0
l ATP- 44.1 OUSE G0000003 0797 1701
dependent 4371
dihydroxya
cetone
kinase/FAD
-AMP lyase
(cyclizing)
Trinucleoti Tnrc6a TF IPI009899 TNR6A_ E9PVT0 ENSMUS 233833 0.42371 0.00 2 809.487 0 0 0 0 0 0 0 0 0
de repeat- 25.2 MOUSE G0000005 0797 4994
containing 2707
gene 6A
protein
Calcium/cal Camk2d ENZ IPI009901 F7A856_ F7A856 ENSMUS 0.42371 0.00 1 0 168.318 0 0 0 0 0 0 0 0
modulin- 42.1 MOUSE G0000005 0797 848
dependent 3819
protein
kinase type
II subunit
delta
Golgi Glg1 TM IPI009901 GSLG1_ F8WHM5 ENSMUS 20340 0.42371 1000.00 1 0 0 0 0 0 0 171.333 0 0 0
apparatus 60.1 MOUSE G0000000 0797 612
protein 1 3316
NAD Nadkd1 ENZ IPI009902 NAKD1_ Q14BL1 ENSMUS 68646 0.42371 1000.00 1 0 0 0 0 0 0 14.1363 0 0 0
kinase 72.2 MOUSE G0000002 0797 2966
domain- 2253
containing
protein 1
Protein Gm174 UK IPI009903 E9Q871_ E9Q871 ENSMUS 0.42371 4.84 10 140.565 0 0 0 0 0 680.425 0 0 0
Gm17434 34 94.1/IPI00 MOUSE G0000009 0797 4817 5536
989309.1 0571
Acyl- Acot1 ENZ IPI009907 ACOT1_ H7BX55/ ENSMUS 26897 0.42371 1000.00 5 0 0 0 0 0 56.8341 0 270.088 0 0
coenzyme 06.1/IPI00 MOUSE O55137 G0000007 0797 0798 0183
A 115871.3 2949
thioesterase
1
Protein Gm827 UK IPI009908 D3Z4B3_ D3Z4B3 ENSMUS 0.42371 1000.00 2 0 0 0 0 0 0 113.116 0 0 0
Gm8271 1 87.1 MOUSE G0000007 0797 9272
9380
Putative 493243 UK IPI009910 Q3V0A3_ Q3V0A3 0.42371 1000.00 1 0 0 0 0 0 95.6556 0 0 0 0
uncharacter 1L22Ri 53.1 MOUSE 0797 1684
ized protein k
Cadherin Celsr1 RCP IPI009910 CELR1_ Q571L9 ENSMUS 12614 0.42371 1000.00 1 0 0 0 0 0 0 46.1230 0 0 0
EGF LAG 59.1 MOUSE G0000001 0797 1951
seven-pass 6028
G-type
receptor 1
Nucleoprot Tpr TP IPI009911 Q32P08_ Q32P08 0.42371 1000.00 2 0 0 0 0 0 0 0 0 0 519.277
ein TPR 03.1 MOUSE 0797 0379
Arf-GAP Asap2 MOD IPI009911 ASAP2_ E9Q3D7/ ENSMUS 211914 0.42371 0.00 2 0 0 0 176.535 180.756 0 0 0 0 0
with SH3 19.1/IPI00 MOUSE Q7SIG6 G0000009 0797 0095 5156
domain, 462750.2 1781|ENS
ANK repeat MUSG00
and PH 00005263
domain- 2
containing
protein 2

- 134 -
Zinc finger Dzip1 DEV IPI010079 DZIP1_M Q8BMD2 ENSMUS 66573 0.42371 0.00 1 0 0 159.807 0 0 0 0 0 0 0
protein 29.1 OUSE G0000004 0797 4831
DZIP1 2156
Intracellula Habp4 TF IPI010080 HABP4_ Q9JKS5 56541 0.42371 0.00 1 0 0 0 0 41.9949 0 0 0 0 0
r 99.1 MOUSE 0797 5714
hyaluronan-
binding
protein 4
Patatin-like Pnpla3 ENZ IPI010083 PLPL3_M E9QNZ9 ENSMUS 116939 0.42371 0.00 1 0 0 195.396 0 0 0 0 0 0 0
phospholip 94.1 OUSE G0000004 0797 3349
ase domain- 1653
containing
protein 3
Junction- Jmy CS IPI010085 JMY_MO E9PW81 ENSMUS 57748 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 32.0518
mediating 48.1 USE G0000002 0797 5672
and - 1690
regulatory
protein
Neuron Nav2 DEV IPI010086 F6Q9M5_ F6Q9M5 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 371.076
navigator 2 90.1 MOUSE G0000005 0797 0847
2512
Cyclic Cngb1 CNL IPI010192 E1AZ71_ E9PXX0 ENSMUS 333329 0.42371 1000.00 1 0 0 0 0 0 0 25.4137 0 0 0
nucleotide- 50.1 MOUSE G0000003 0797 3803
gated cation 1789
channel
beta-1
Dedicator Dock6 MOD IPI010231 DOCK6_ Q8VDR9 ENSMUS 319899 0.42371 1000.00 1 0 0 0 0 0 0 0 79.7565 0 0
of 37.1 MOUSE G0000003 0797 584
cytokinesis 2198
protein 6
Putative Ahcyl2 ENZ IPI010232 SAHH3_ Q80TQ9 ENSMUS 74340 0.42371 1000.00 2 0 0 0 0 0 0 0 0 59.5477 0
adenosylho 51.1 MOUSE G0000002 0797 7709
mocysteina 9772
se 3
Homeobox- Hmbox TF IPI010232 HMBX1_ F7B1S4 ENSMUS 219150 0.42371 1000.00 1 0 0 0 0 0 0 0 20.4448 0 0
containing 1 73.1 MOUSE G0000002 0797 8095
protein 1 1972
22 kDa UK IPI010266 G3UXI5 0.42371 0.00 1 0 0 152.043 0 0 0 0 0 0 0
protein 48.1 0797 8815
Neurexin- Nrxn1 CS IPI010267 NRX1B_ G3UXK2 ENSMUS 0.42371 1000.00 1 0 0 0 0 0 0 0 0 0 188.979
1-beta 32.1 MOUSE G0000002 0797 9085
4109
Protein Ly6g6e UK IPI010269 G3UXD4 G3UXD4 ENSMUS 0.42371 0.00 1 0 0 42.3619 0 0 0 0 0 0 0
Ly6g6e 35.1 _MOUSE G0000001 0797 2818
3766
RNA- Nova2 TF IPI010270 G3UYX3 G3UYX3 ENSMUS 0.42371 0.00 1 0 56.6485 0 0 0 0 0 0 0 0
binding 74.1 _MOUSE G0000003 0797 5278
protein 0411
Nova-2
Glutamate Gria1 CNL IPI010271 GRIA1_ F6YNQ1 ENSMUS 14799 0.42371 1000.00 1 0 0 0 0 0 77.3242 0 0 0 0
receptor 1 66.1 MOUSE G0000002 0797 6548
0524
Chromodo Chd2 ENZ IPI010274 E9PZM4_ F7CDZ7 ENSMUS 244059 0.42371 1000.00 1 0 0 0 0 0 0 0 93.6172 0 0
main- 18.1 MOUSE G0000007 0797 4439
helicase- 8671
DNA-

- 135 -
binding
protein 2
Large Bag6 CHA IPI010274 BAG6_M G3V013 ENSMUS 224727 0.42371 0.00 1 0 0 0 119.524 0 0 0 0 0 0
proline-rich 23.1 OUSE G0000002 0797 394
protein 4392
BAG6
General Gtf2i TF IPI010275 GTF2I_M G3UYD0 ENSMUS 14886 0.42371 1000.00 1 0 0 0 0 0 48.5578 0 0 0 0
transcriptio 15.1 OUSE G0000006 0797 9675
n factor II-I 0261
26S Psmd11 MOD IPI010275 PSD11_M G3UZ28 ENSMUS 69077 0.42371 1000.00 1 0 0 0 0 0 0 9.03955 0 0 0
proteasome 52.1 OUSE G0000001 0797 375
non- 7428
ATPase
regulatory
subunit 11
Bifunctiona Ndst3 ENZ IPI010276 NDST3_ G3UXE3 ENSMUS 83398 0.42371 0.00 1 0 330.616 0 0 0 0 0 0 0 0
l heparan 71.1 MOUSE G0000002 0797 315
sulfate N- 7977
deacetylase
/N-
sulfotransfe
rase 3
Protein Arhgef3 MOD IPI010276 E2QRQ2_ E2QRQ2 ENSMUS 0.42371 0.00 1 0 0 110.146 0 0 0 0 0 0 0
D630013G 8 96.1 MOUSE G0000004 0797 4331
24Rik 0969
Receptor- Ptprd ENZ IPI010277 PTPRD_ G3UYU6/ ENSMUS 19266 0.42371 1000.00 2 0 0 0 0 0 0 0 0 41.5844 167.886
type 06.1/IPI00 MOUSE Q3V315 G0000002 0797 5351 433
tyrosine- 621145.4 8399
protein
phosphatas
e delta
Uncharacte Cyp2j7- ENZ IPI010277 G3UZ38_ G3UZ38 ENSMUS 0.42371 0.00 1 0 0 0 0 75.7344 0 0 0 0 0
rized ps 88.1 MOUSE G0000008 0797 3518
protein 1362
Cyp2j7-ps
Translocato Tspo TP mitocho IPI001202 TSPO_M P50637 ENSMUS 12257 0.44068 2.41 1 0 0 59.4982 0 0 0 0 74.8039 68.8068 0
r protein ndria 83.1 OUSE G0000004 6016 4651 8367 5515
1736
Aspartate-- Dars2 ENZ mitocho IPI002737 SYDM_M Q8BIP0 ENSMUS 226539 0.44068 2.98 1 0 0 0 0 112.348 197.280 0 0 0 137.298
tRNA ndria 67.3 OUSE G0000002 6016 5008 1892 1787
ligase, 6709
mitochondr
ial
Solute Slc25a3 TP mitocho IPI006481 S2535_M Q5SWT3 ENSMUS 71998 0.44068 0.35 3 109.377 85.5118 0 0 0 0 0 0 68.5423 0
carrier 5 ndria 90.1 OUSE G0000001 6016 3192 4843 007
family 25 8740
member 35
Nascent Naca TP muscle IPI001118 NACAM_ P70670 ENSMUS 17938 0.44068 5.22 5 0 0 445.235 0 0 652.842 0 0 0 1673.06
polypeptide 31.2 MOUSE G0000006 6016 8739 9469 1224
-associated 1315
complex
subunit
alpha,
muscle-
specific
form

- 136 -
Myomesin- Myom1 CS muscle IPI002811 MYOM1_ Q62234 ENSMUS 17929 0.44068 9.33 8 0 0 32.2647 0 0 0 40.0578 0 0 261.009
1 09.3 MOUSE G0000002 6016 8152 1597 1046
4049
Troponin Tnnc1 CS muscle IPI009884 TNNC1_ E9Q8P0 ENSMUS 21924 0.44068 3.38 2 0 0 74.2226 0 0 0 81.5145 169.503 0 0
C, slow 40.1 MOUSE G0000002 6016 0038 1184 9819
skeletal and 1909|ENS
cardiac MUSG00
muscles 00009189
8
Inter-alpha- Itih1 INH secreted IPI009873 ITIH1_M Q61702 ENSMUS 16424 0.44068 0.17 2 157.728 0 55.8818 0 0 0 0 36.9133 0 0
trypsin 25.1 OUSE G0000000 6016 3365 5884 0789
inhibitor 6529
heavy chain
H1
Putative Glyr1 ENZ IPI001118 GLYR1_ Q922P9 ENSMUS 74022 0.44068 0.34 1 86.5743 0 56.7959 0 0 0 0 49.0728 0 0
oxidoreduct 21.6 MOUSE G0000002 6016 3345 4412 2275
ase GLYR1 2536
Myelin Mpz CS IPI001177 MYP0_M P27573 17528 0.44068 0.21 2 0 0 117.636 0 244.165 0 0 0 0 75.7947
protein P0 35.1 OUSE 6016 3536 3603 1646
60S Rpl11 RIB IPI001187 RL11_M D3YW69 ENSMUS 67025 0.44068 0.18 2 0 0 0 289.593 87.7181 0 0 0 0 66.8269
ribosomal 07.1 OUSE G0000006 6016 1574 8098 9759
protein L11 6592|ENS
MUSG00
00005929
1
Perilipin-4 Plin4 MOD IPI001311 PLIN4_M O88492 ENSMUS 57435 0.44068 0.31 5 231.432 0 127.733 0 0 0 0 111.473 0 0
13.4 OUSE G0000000 6016 7257 3948 6222
2831
Serum Sdpr SIG IPI001356 SDPR_M Q63918 ENSMUS 20324 0.44068 0.33 6 305.354 0 306.279 0 0 200.989 0 0 0 0
deprivation 60.5 OUSE G0000004 6016 8094 442 4996
-response 5954
protein
DNA Dnmt3a ENZ IPI001721 DNM3A_ O88508 ENSMUS 13435 0.44068 3.14 2 0 0 0 76.7710 0 0 0 158.907 82.0393 0
(cytosine- 29.1 MOUSE G0000002 6016 831 0863 7245
5)- 0661
methyltrans
ferase 3A
Zfp273 Zfp273 TF IPI002221 Q505K9_ Q505K9 0.44068 0.36 2 232.663 195.909 0 0 0 0 154.767 0 0 0
protein 16.5 MOUSE 6016 0405 1283 6531
Ras-related Rab26 TP IPI002243 RAB26_ Q8BRM8 ENSMUS 328778 0.44068 0.17 3 0 0 0 809.268 636.318 247.917 0 0 0 0
protein 19.1 MOUSE G0000007 6016 5803 9328 6479
Rab-26 9657
Phosphoglu Pgm5 CS IPI002697 PGM5_M Q8BZF8 ENSMUS 226041 0.44068 0.26 4 254.999 0 386.513 0 0 0 0 169.785 0 0
comutase- 50.2 OUSE G0000004 6016 4368 9986 2654
like protein 1731
5
Protein Dom3z ENZ IPI003094 DOM3Z_ O70348 ENSMUS 112403 0.44068 0.14 1 0 116.019 0 0 124.239 0 34.3657 0 0 0
Dom3Z 99.4 MOUSE G0000004 6016 9037 372 0123
0482
Zinc finger Zfp831 TF IPI003546 A2ADM8 A2ADM8 ENSMUS 10004375 0.44068 0.28 1 335.624 174.391 0 0 0 0 140.609 0 0 0
protein 831 28.8 _MOUSE G0000005 7 6016 4975 2412 8026
0600
Protein E03001 UK IPI003784 F6XLV1_ F6XLV1 ENSMUS 0.44068 0.33 4 454.706 0 363.430 0 0 268.034 0 0 0 0
E030010N0 0N08Ri 46.5 MOUSE G0000008 6016 0999 296 9791
8Rik k 4989
Transmemb TM IPI004077 CI091_M Q8R239 ENSMUS 230279 0.44068 0.35 1 102.772 74.9556 0 0 0 0 0 0 61.7397 0

- 137 -
rane protein 32.2 OUSE G0000004 6016 3842 1287 2807
C9orf91 5917
homolog
Telomere- Rif1 CC IPI004081 RIF1_MO Q6PR54 ENSMUS 51869 0.44068 0.37 3 376.143 358.616 0 0 0 268.774 0 0 0 0
associated 25.2 USE G0000003 6016 368 401 5259
protein 6202
RIF1
Protein Fam117 UK IPI004614 F117B_M Q3U3E2 ENSMUS 72750 0.44068 0.45 1 0 78.4851 64.7146 0 0 0 0 64.2146 0 0
FAM117B b 75.5 OUSE G0000004 6016 8881 4898 3325
1040
Uncharacte Kiaa116 ENZ IPI004642 K1161_M Q69ZQ1 ENSMUS 329828 0.44068 2.59 1 0 0 0 0 628.528 865.690 0 761.464 0 0
rized family 1 56.2 OUSE G0000004 6016 5305 9936 6823
31 6312
glucosidase
KIAA1161
Olfactory Olfr259 RCP IPI004669 Q8VG39_ Q8VG39 0.44068 0.38 1 59.0325 69.8564 0 0 0 0 0 0 0 48.6055
receptor 55.4 MOUSE 6016 594 0608 367
MOR172-
3, Olfr259
HMG Hmgxb TF IPI006200 Q6PEF4_ Q8R168 106894 0.44068 5.41 2 0 0 0 0 146.762 0 218.146 0 0 575.372
domain- 3 00.2 MOUSE 6016 5582 282 746
containing
protein 3
Mitotic Bub3 CC IPI006267 BUB3_M Q9WVA3 ENSMUS 12237 0.44068 0.37 1 84.1050 0 143.037 0 0 0 0 83.0893 0 0
checkpoint 52.2 OUSE G0000006 6016 6635 1305 6473
protein 6979
BUB3
BTB/POZ Kctd2 CNL IPI006496 KCTD2_ Q8CEZ0 0.44068 12.35 3 0 0 33.9510 0 0 0 77.5382 0 0 341.766
domain- 23.4 MOUSE 6016 7465 9489 7318
containing
protein
KCTD2
Wolframin Wfs1 MOD IPI006528 WFS1_M Q3UN10 ENSMUS 22393 0.44068 0.37 1 116.697 0 0 0 109.309 0 0 0 83.8796 0
71.1 OUSE G0000003 6016 9018 5766 4777
9474
Protein C33001 UK IPI006532 E9Q7C4_ Q3UYV6 ENSMUS 215476 0.44068 0.16 3 761.122 0 0 753.546 0 0 0 0 238.670 0
C330019G 9G07Ri 20.2 MOUSE G0000005 6016 1309 7908 3177
07Rik k 4280
Protein Sbno1 UK IPI006606 SBNO1_ Q3TMM7 0.44068 0.29 4 508.269 0 355.958 0 0 0 251.089 0 0 0
strawberry 73.3 MOUSE 6016 7833 633 9922
notch
homolog 1
Neurofilam Nefh CS IPI006758 NFH_MO Q80TQ3 ENSMUS 380684 0.44068 0.35 3 846.348 0 0 920.094 0 625.483 0 0 0 0
ent heavy 55.3 USE G0000002 6016 1565 2135 6527
polypeptide 0396
MCG67716 Gm553 UK IPI007554 G3UW64 G3UW64 ENSMUS 433597 0.44068 0.20 2 0 90.5617 30.6520 0 0 0 0 0 24.3572 0
8 12.1 _MOUSE G0000009 6016 3359 0441 6112
0527
Nucleolar Nolc1 CC IPI007614 Q8CE21_ Q8CE21 70769 0.44068 0.10 3 360.042 66.7300 0 0 0 43.4828 0 0 0 0
and coiled- 17.1 MOUSE 6016 4182 2889 4034
body
phosphopro
tein 1
Integrin Itga1 CS IPI007614 ITA1_MO Q3URV2 ENSMUS 109700 0.44068 0.17 1 307.397 0 0 384.570 0 0 120.233 0 0 0
alpha-1 88.1 USE G0000004 6016 8992 4937 3539
2284

- 138 -
Ensconsin Map7 CS IPI007984 MAP7_M O88735 17761 0.44068 0.40 1 405.369 504.727 0 0 0 0 0 0 364.345 0
90.2 OUSE 6016 5643 6972 69
Formin-1 Fmn1 CS IPI008282 FMN1_M Q05860 ENSMUS 14260 0.44068 5.30 1 0 115.995 0 0 0 0 179.770 0 0 434.578
36.1 OUSE G0000004 6016 7012 0261 1467
4042
Annexin Anxa11 CC IPI008483 ANX11_ P97384 ENSMUS 11744 0.44068 0.40 2 44.2450 0 39.6328 0 0 0 0 33.7833 0 0
A11 82.2 MOUSE G0000002 6016 8745 2048 302
1866
Heat shock Hspb1 CHA IPI008575 HSPB1_ D3YZ06 ENSMUS 15507 0.44068 0.12 3 0 0 190.507 198.804 0 0 46.0625 0 0 0
protein 48.1 MOUSE G0000000 6016 1809 4414 1696
beta-1 4951
Glutathione Gsta2 ENZ IPI009746 GSTA2_ F6SC55 ENSMUS 0.44068 0.27 1 30.0546 0 24.8627 0 0 0 0 14.6594 0 0
S- 00.1 MOUSE G0000009 6016 8603 4504 9087
transferase 0802
A2
Protein CCDC1 UK IPI009862 E9Q1U1_ E9Q1G4 ENSMUS 320226 0.44068 0.40 1 237.041 264.212 0 0 0 199.142 0 0 0 0
4930473A0 71 61.2 MOUSE G0000005 6016 9925 2017 3641
6Rik 2407
(Uncharact
erized
protein
C9orf93)
Centromere Cenpf CC IPI009868 E9Q3P4_ Q3TZQ0 ENSMUS 108000 0.44068 0.35 1 238.120 206.213 0 0 0 157.007 0 0 0 0
protein F 75.1 MOUSE G0000002 6016 2647 627 542
6605
Tryptophan Tdo2 ENZ IPI009888 T23O_M C5NSA7 ENSMUS 56720 0.44068 0.31 1 392.608 0 206.169 0 0 0 0 0 183.372 0
2,3- 35.1 OUSE G0000002 6016 7155 8119 9395
dioxygenas 8011
e
Histone- Mll ENZ IPI010078 MLL1_M P55200 ENSMUS 214162 0.44068 2.35 3 0 0 345.432 0 0 0 0 429.004 381.795 0
lysine N- 45.2 OUSE G0000000 6016 9029 2185 3312
methyltrans 2028
ferase MLL
Keratin, Krt10 CS IPI010085 K1C10_M E9QLP8 ENSMUS 16661 0.44068 4.18 2 0 54.7995 0 0 0 68.6139 0 0 160.617 0
type I 64.1 OUSE G0000001 6016 402 2465 4606
cytoskeletal 9761
10
Small Sumo3 SIG IPI010272 SUMO3_ G3UZX6 ENSMUS 20610 0.44068 0.37 1 38.2914 0 0 0 61.2266 0 0 36.3822 0 0
ubiquitin- 99.1 MOUSE G0000002 6016 6067 1202 1645
related 0265
modifier 3
Dynamin-1 Dnm1 TP IPI008955 DYN1_M F6W8Z8/ ENSMUS 13429 0.44215 2.42 2 41.5271 0 72.5927 0 0 0 137.857 0 0 0
17.1/IPI00 OUSE P39053 G0000002 4427 2111 8934 0751
753037.5 6825
H-2 class I H2-L MHC IPI001099 HA1L_M P01897/Q 0.44390 0.91 2 31.5204 41.7948 31.5568 0 0 0 15.4612 34.8075 45.3688 0
histocompa 96.1/IPI00 OUSE 31151 7043 2977 4339 6495 9613 8837 0668
tibility 845774.1
antigen, L-
D alpha
chain
Titin Ttn CS IPI006049 TITIN_M Q3TZL3/ ENSMUS 0.44398 0.93 287 6264.25 11775.4 6117.20 0 8836.71 5660.73 3928.22 4887.39 0 16101.8
69.3/IPI00 OUSE A2ASS6 G0000005 0285 6641 9883 5573 0102 6056 9421 693 4581
753639.1/ 1747
IPI007562
57.1
Tropomyos Tpm3 CS muscle IPI008806 TPM3_M D3Z6I8/P ENSMUS 59069 0.44405 0.84 28 738.935 955.613 604.541 0 812.693 600.756 719.793 366.166 581.836 985.095

- 139 -
in alpha-3 79.1/IPI00 OUSE 21107/Q8 G0000002 9187 2462 1574 7863 9929 7353 7794 2684 6236 5239
chain 278611.7/ K0Z5 7940
IPI002300
44.5/IPI00
169707.2
Hemoglobi Hba TP IPI001106 HBA_MO F7CAE1/ ENSMUS 0.44549 1.03 23 136600. 92335.4 94964.2 144657. 79332.3 83654.9 176912. 111762. 128215. 63985.4
n subunit 58.1/IPI00 USE Q91VB8 G0000006 6623 3044 2391 7965 1305 475 5205 8369 9909 0391 9518
alpha 845802.1 9917|ENS
MUSG00
00006991
9
Hemoglobi Hbb-b1 TP IPI008310 HBB1_M E9Q223/ ENSMUS 10050360 0.44858 0.97 44 103624. 147262. 140138. 199876. 224975. 146800. 204928. 173609. 200543. 67860.6
n subunit 55.3/IPI00 OUSE A8DUK4/ G0000005 5 7197 7143 6044 6689 0275 5881 6556 803 4775 6052 8119
beta-1 988950.1/ P02088 2305|ENS
IPI007621 MUSG00
98.2/IPI00 00007394
985596.1 0
Alpha- Defa- SIG secreted IPI005532 DFAR1_ D3YX03 ENSMUS 0.45064 1.67 1 393.465 254.291 0 0 0 185.022 0 297.624 397.983 203.657
defensin- rs1 88.2 MOUSE G0000007 3728 8528 5052 7291 2928 3112 6731
related 9113|ENS
sequence 1 MUSG00
00007911
4
Aldehyde Aldh3a ENZ IPI001112 AL3A1_ P47739 0.45064 0.60 1 405.659 434.605 0 408.977 83.3668 303.595 0 496.646 0 0
dehydrogen 1 22.1 MOUSE 3728 0013 7986 3943 8486 1629 3013
ase, dimeric
NADP-
preferring
Mast cell Cpa3 ENZ IPI001263 CBPA3_ P15089 ENSMUS 12873 0.45064 1.63 7 137.822 0 331.266 0 0 154.616 67.8055 301.753 0 238.931
carboxypep 16.1 MOUSE G0000000 3728 9787 3557 5857 486 8794 3864
tidase A 1865
Histone H2afz TF IPI003317 H2AZ_M P0C0S6 ENSMUS 51788 0.45064 1.49 3 0 3545.48 0 0 6600.44 2363.96 0 3752.54 4044.41 4907.23
H2A.Z 34.5 OUSE G0000003 3728 043 517 7031 5018 6598 8022
7894
NADH Ndufs2 ENZ mitocho IPI008307 NDUS2_ D3YXT0 ENSMUS 226646 0.46334 0.90 9 368.108 448.999 390.264 150.618 0 283.706 0 238.583 355.168 347.176
dehydrogen ndria 66.1 MOUSE G0000001 3883 9145 328 1309 9169 3115 8271 5261 6696
ase 3593
[ubiquinone
] iron-sulfur
protein 2,
mitochondr
ial
Aquaporin- Aqp1 CNL IPI001231 AQP1_M Q02013 ENSMUS 11826 0.46334 0.74 2 160.201 100.290 140.460 101.752 0 70.5380 85.5855 110.650 103.195 0
1 83.3 OUSE G0000000 3883 6133 5337 6324 0859 7925 9877 4476 2162
4655
NADH Ndufv1 ENZ mitocho IPI009284 NDUV1_ D3YUM1 ENSMUS 17995 0.46630 0.96 20 541.821 568.293 476.457 470.894 0 466.298 136.467 908.541 463.281 0
dehydrogen ndria 16.1/IPI00 MOUSE /D3Z1U9/ G0000003 6846 1704 6617 0674 7248 2897 1882 8531 8514
ase 928387.1/ Q91YT0 7916
[ubiquinone IPI001304
] 60.1
flavoprotei
n 1,
mitochondr
ial
Coiled-coil- Chchd3 SCA mitocho IPI001335 CHCH3_ Q9CRB9/ ENSMUS 66075 0.46698 1.04 9 173.614 239.377 243.335 138.586 0 184.382 113.216 234.948 291.150 0
helix- ndria 62.1/IPI00 MOUSE Q9D9P1 G0000005 2208 3077 0069 826 9037 0329 394 8718 4496
coiled-coil- 754739.1 3768

- 140 -
helix
domain-
containing
protein 3,
mitochondr
ial
Protein Gm559 UK IPI002288 Q8CDK1 Q8CDK1 ENSMUS 434171 0.46894 0.45 2 0 0 0 0 86.5918 62.6870 15.3701 0 0 0
Gm5591 1 41.1/IPI00 _MOUSE G0000006 0477 817 2232 3145
986849.1 0565
A-kinase Akap1 SCA mitocho IPI002305 AKAP1_ O08715 ENSMUS 11640 0.46962 0.79 4 359.217 0 472.272 0 108.241 255.149 92.2473 267.891 370.788 0
anchor ndria 89.2/IPI00 MOUSE G0000001 0332 3653 2428 0161 9592 5039 7525 6378
protein 1, 230590.2 8428
mitochondr
ial
Heterogene Hnrnpk TF IPI008754 HNRPK_ D3Z5X4/ ENSMUS 15387 0.47108 0.55 7 158.962 0 0 0 0 0 0 121.264 0 52.6191
ous nuclear 20.1/IPI00 MOUSE Q8BT23 G0000006 5964 2347 9108 9078
ribonucleop 458719.1 3902|ENS
rotein K MUSG00
00002154
6
Probable Mycbp2 ENZ IPI009703 MYCB2_ F6SMY7/ ENSMUS 105689 0.47172 0.63 5 247.973 137.546 0 0 0 0 30.6991 187.878 143.561 0
E3 11.1/IPI01 MOUSE F7CZG3 G0000003 1511 4118 561 1897 9008 0565
ubiquitin- 023143.1 3004
protein
ligase
MYCBP2
Lipopolysa Lrba TP IPI009863 LRBA_M Q8BSM6/ ENSMUS 80877 0.47973 0.62 3 365.337 456.174 261.592 0 0 259.301 109.698 395.729 125.176 221.493
ccharide- 51.1/IPI00 OUSE Q9ESE1 G0000002 5317 754 4811 2772 4483 3267 5732 8564 7429
responsive 227851.1 8080
and beige-
like anchor
protein
Microsomal Mgst1 ENZ mitocho IPI008803 MGST1_ D3YU60 ENSMUS 56615 0.48017 1.74 2 0 0 0 0 251.518 152.409 0 132.263 0 152.632
glutathione ndria 62.1 MOUSE G0000000 689 6 8415 6133 5716
S- 8540
transferase
1
Galectin-1 Lgals1 CS secreted IPI002295 LEG1_M P16045 ENSMUS 16852 0.48017 0.65 4 0 0 0 0 771.381 237.155 36.4565 0 0 226.178
17.5 OUSE G0000006 689 3052 4123 7249 2152
8220
Murinoglob Mug2 INH secreted IPI002712 MUG2_M P28666 ENSMUS 17837 0.48017 1.55 14 0 1011.50 0 0 0 582.063 338.752 0 0 646.892
ulin-2 62.8 OUSE G0000003 689 2962 6844 9059 7959
0131
Haptoglobi Hp ENZ secreted IPI004091 HPT_MO Q61646 ENSMUS 15439 0.48017 10.87 4 175.562 332.410 268.064 0 0 0 8435.91 0 0 0
n 48.2 USE G0000003 689 7029 7388 0585 9294
1722
Carbohydra Chst10 ENZ IPI001294 CHSTA_ Q6PGK7 ENSMUS 98388 0.48017 2.04 1 335.604 0 0 0 0 228.678 137.682 0 0 317.882
te 74.2 MOUSE G0000002 689 0736 2622 1438 9639
sulfotransfe 6080
rase 10
Casein Csnk1e ENZ IPI003213 KC1E_M Q9JMK2 ENSMUS 27373 0.48017 0.49 1 0 522.753 606.331 0 220.792 0 0 662.731 0 0
kinase I 96.1 OUSE G0000002 689 4565 204 3418 1318
isoform 2433
epsilon
Tetratricop Ttc24 UK IPI004081 TTC24_M Q8BYG0 ENSMUS 214191 0.48017 1.47 1 0 0 0 0 2629.03 712.437 0 0 1307.57 1832.74
eptide 54.1 OUSE G0000005 689 6617 3975 2246 695

- 141 -
repeat 1036
protein 24
Phosphogly Pgk2 ENZ IPI005550 PGK2_M P09041 ENSMUS 18663 0.48017 2.16 4 748.060 0 0 0 0 586.773 304.340 0 724.128 0
cerate 60.3 OUSE G0000003 689 264 3601 6168 6037
kinase 2 1233
Bromodom Baz2b TF IPI006227 A2AUY4 Q8C0K4 ENSMUS 407823 0.48017 1.29 4 0 0 0 312.185 0 0 74.2580 259.334 0 68.4875
ain adjacent 26.2 _MOUSE G0000002 689 3855 3472 1042 6305
to zinc 6987
finger
domain
protein 2B
Actin- Actr5 TF IPI007549 ARP5_M Q80US4 0.48017 0.91 1 0 0 0 460.926 0 120.979 108.592 0 188.364 0
related 60.1 OUSE 689 3655 2481 4551 7527
protein 5
Round Rsbn1 UK IPI008581 RSBN1_ D6RG56 ENSMUS 229675 0.48017 2.27 1 239.551 0 0 0 0 109.274 0 196.389 0 237.937
spermatid 98.1 MOUSE G0000004 689 7234 6415 7508 6779
basic 4098
protein 1
Purkinje Pcp2 MOD IPI008747 PCP2_M A8IK50 ENSMUS 18545 0.48017 1.29 1 0 0 317.094 0 0 0 85.2477 195.974 127.412 0
cell protein 90.3 OUSE G0000000 689 7032 1598 3305 6916
2 4630
Adenylate Akd1 ENZ IPI009903 G3UYQ4 G3UYQ4 ENSMUS 0.48017 0.73 5 102.187 306.965 45.7938 0 0 0 0 333.160 0 0
kinase 55.1 _MOUSE G0000009 689 8435 7685 0939 1543
domain- 1415
containing
protein 1
Activating Trip4 TF IPI010078 TRIP4_M Q9QXN3 ENSMUS 56404 0.48017 2.33 2 0 0 220.261 0 0 183.922 0 201.075 128.979 0
signal 01.2 OUSE G0000003 689 7715 1845 0175 6259
cointegrator 2386
1
DNA Mcm9 CC IPI009909 MCM9_ Q3TEA4/ ENSMUS 71567 0.48200 0.53 4 0 0 0 0 680.437 448.235 0 0 0 270.644
replication 33.1/IPI00 MOUSE Q2KHI9 G0000005 9737 1202 2893 1282
licensing 857534.1 8298
factor
MCM9
Collagen Col2a1 CS secreted IPI006212 CO2A1_ P28481 ENSMUS 12824 0.48635 0.69 7 450.511 0 513.184 0 0 0 0 159.035 599.136 234.068
alpha-1(II) 55.2/IPI00 MOUSE G0000002 0629 9198 901 2496 5927 0779
chain 828753.1 2483
Amine Maob ENZ mitocho IPI009886 AOFB_M E9PVL9/ ENSMUS 109731 0.48822 0.99 10 149.942 153.378 129.554 0 69.2258 165.572 35.3287 125.201 169.091 0
oxidase ndria 77.1/IPI00 OUSE Q8BW75 G0000004 0275 0242 8262 9896 8255 4885 6709 6923 4832
[flavin- 226140.6 0147
containing]
B
Sodium/pot Atp1a2 TP IPI008307 AT1A2_ D3YVX6/ ENSMUS 98660 0.48931 1.03 11 148.357 0 0 0 283.818 170.415 0 0 0 272.874
assium- 41.1/IPI00 MOUSE D3YYN7 G0000000 6383 6562 9239 7117 2101
transporting 762871.2 7097
ATPase
subunit
alpha-2
Methylmal Aldh6a ENZ mitocho IPI009864 MMSA_ Q8K0L1/ ENSMUS 104776 0.49538 1.00 18 1852.58 1500.80 1310.77 829.969 499.008 1071.12 492.888 1644.22 1695.18 1109.17
onate- 1 ndria 14.1/IPI00 MOUSE Q9EQ20 G0000002 5895 8893 6343 4372 0468 3459 6314 6465 4669 4701 1653
semialdehy 461964.3 1238
de
dehydrogen
ase
[acylating],

- 142 -
mitochondr
ial
Vitamin D- Gc TP secreted IPI001261 VTDB_M P21614 ENSMUS 14473 0.50381 0.36 6 0 188.447 89.1982 0 420.656 0 0 149.708 105.052 0
binding 84.7 OUSE G0000003 2429 1015 4796 3453 6315 2184
protein 5540
Kelch-like Klhl20 CS IPI002262 KLH20_ Q8VCK5 ENSMUS 226541 0.50381 3.36 1 0 0 457.726 0 588.098 397.365 2121.82 0 994.230 0
protein 20 09.3 MOUSE G0000002 2429 0328 2282 182 3927 1603
6705
B-cell Bcap31 TP IPI002304 BAP31_ Q61335 27061 0.50381 0.31 3 115.831 38.2447 119.817 0 0 42.5014 41.0434 0 0 0
receptor- 22.6 MOUSE 2429 2614 0474 0317 215 9994
associated
protein 31
Hemoglobi Hbb-b2 TP IPI003164 HBB2_M P02089 15130 0.50381 1.95 13 0 15807.3 0 0 47033.8 43200.2 56947.8 22528.5 0 0
n subunit 91.4 OUSE 2429 7437 2844 3176 808 991
beta-2
Proteasome Ecm29 SCA IPI003216 ECM29_ Q6PDI5 ENSMUS 230249 0.50381 2.03 2 40.9348 103.770 0 0 0 83.7481 62.0453 147.893 0 0
-associated 46.4 MOUSE G0000005 2429 7847 4508 7366 4318 7561
protein 0812
ECM29
homolog
Protein Gm22 UK IPI003543 F6U3X3_ F6U3X3 ENSMUS 0.50381 9.00 7 630.562 337.722 0 0 0 7767.01 216.235 0 735.377 0
Gm22 00.5 MOUSE G0000004 2429 0525 1357 2281 9479 6349
3903
Synemin Synm CS IPI004110 SYNEM_ Q70IV5 ENSMUS 233335 0.50381 1.52 6 799.681 338.287 0 0 0 363.658 0 830.064 0 532.651
45.1 MOUSE G0000003 2429 7654 202 6148 2061 5266
0554
Protein Pot1b UK IPI006243 H7BX60_ Q3TNS5 ENSMUS 72836 0.50381 0.56 1 72.4112 94.7422 75.1113 0 0 0 0 42.6881 0 92.0260
Pot1b 76.3 MOUSE G0000002 2429 753 8447 9845 6862 2074
4174
Ral Ralgapa MOD IPI007510 RGPA2_ F7CGP0 ENSMUS 241694 0.50381 0.17 5 6.58151 0 0 342.172 69.8415 34.2054 37.1857 0 0 0
GTPase- 2 17.4 MOUSE G0000003 2429 4678 2684 2989 3035 2134
activating 7110
protein
subunit
alpha-2
NADH Ndufa1 TP mitocho IPI003440 NDUAC_ Q7TMF3 ENSMUS 66414 0.51790 1.90 6 89.2528 0 153.840 0 96.1283 208.854 0 142.199 292.256 0
dehydrogen 2 ndria 04.3 MOUSE G0000002 4396 3602 8341 9278 3211 7734 2185
ase 0022
[ubiquinone
] 1 alpha
subcomplex
subunit 12
Probable Cars2 TF mitocho IPI004737 SYCM_M Q9CX12 71941 0.51790 0.60 1 192.046 176.745 0 150.519 0 0 0 74.8010 157.397 77.2547
cysteine-- ndria 57.1 OUSE 4396 4223 9747 0394 6801 3174 3219
tRNA
ligase,
mitochondr
ial
Cathepsin Ctsb ENZ IPI001135 CATB_M P10605 ENSMUS 13030 0.51790 0.66 6 365.602 206.420 274.435 0 0 142.232 0 231.350 186.603 0
B 17.1 OUSE G0000002 4396 8378 8578 0516 3248 6771 7207
1939
Clathrin Cltc CS IPI001699 CLH_MO Q68FD5 ENSMUS 67300 0.51790 0.44 9 194.766 0 88.6218 0 341.434 56.2607 40.4005 0 0 176.008
heavy chain 16.11 USE G0000004 4396 429 8374 733 3951 7831 8804
1 7126
Coiled-coil Ccdc14 UK IPI003783 B2RW38_ B2RW38 ENSMUS 381229 0.51790 0.65 1 118.081 168.707 104.057 0 0 59.8645 0 86.2430 108.490 0
domain 7 85.3 MOUSE G0000004 4396 9034 1826 7874 6056 7131 3184

- 143 -
containing 6585
147
Integrin Itga11 CS IPI004171 ITA11_M P61622 0.51790 0.62 3 542.650 413.887 718.790 0 0 191.748 0 405.616 437.404 0
alpha-11 68.1 OUSE 4396 7004 5117 6578 133 1203 7042
NADH Ndufa5 TP mitocho IPI003313 NDUA5_ Q9CPP6 ENSMUS 68202 0.52580 1.43 4 158.855 115.126 0 0 73.3275 190.686 27.5453 167.023 109.847 0
dehydrogen ndria 32.6 MOUSE G0000002 8953 9529 2295 3882 3257 7401 2921 4134
ase 3089
[ubiquinone
] 1 alpha
subcomplex
subunit 5;
AltName:
Full=Comp
lex I
subunit
B13;
AltName:
Full=Comp
lex I-13kD-
B;
Short=CI-
13kD-B;
AltName:
Full=NAD
H-
ubiquinone
oxidoreduct
ase 13 kDa-
B subunit;
Mitochondr Mtch2 TP mitocho IPI007541 MTCH2_ A2AFW6 ENSMUS 56428 0.52580 1.31 5 87.8527 392.339 0 0 137.900 236.129 0 166.961 314.780 89.0435
ial carrier ndria 42.1 MOUSE G0000002 8953 1218 5083 7431 3839 3087 698 9192
homolog 2 7282
Coiled-coil Ccdc11 UK IPI001296 CC110_M Q3V125 ENSMUS 212392 0.52580 0.82 2 293.709 0 326.488 358.116 0 196.088 148.106 190.869 0 269.991
domain- 0 08.5 OUSE G0000007 8953 4213 3227 1738 4378 2034 6717 1137
containing 1104
protein 110
Brain- Begain CS IPI003809 BEGIN_ Q68EF6 380785 0.52580 0.46 2 183.406 246.260 288.485 0 0 66.5763 41.0473 91.1828 128.829 0
enriched 50.7 MOUSE 8953 7295 0461 4339 2461 4172 8025 0983
guanylate
kinase-
associated
protein
Leucine- Lrig1 MOD IPI010080 LRIG1_M E9PVH2 ENSMUS 16206 0.52580 0.14 1 378.314 235.528 73.6253 0 0 15.9872 0 24.9039 34.5242 23.1800
rich repeats 23.1 OUSE G0000003 8953 0667 786 7756 8062 3687 6502 5695
and 0029
immunoglo
bulin-like
domains
protein 1
Intercellula Icam2 CS IPI010277 ICAM2_ G3UWJ5 ENSMUS 15896 0.52580 0.67 2 780.702 0 1025.02 1289.25 552.826 680.339 418.672 0 1358.64 0
r adhesion 68.1 MOUSE G0000000 8953 808 0421 9778 4024 3419 9707 6382
molecule 2 1029
High Hmgb1l CC IPI002295 Q8CH24_ Q8CH24 0.52961 1.47 2 119.814 138.368 133.939 0 0 101.321 45.1715 179.545 139.154 110.460
mobility 70.1 MOUSE 9299 0977 4827 9602 8889 6652 738 916 8646
group
protein
like-6

- 144 -
HMG-L6
Trifunction Hadhb ENZ mitocho IPI001156 ECHB_M Q99JY0 ENSMUS 231086 0.54761 0.84 15 5649.32 6260.04 5873.69 6579.20 2800.26 3902.31 2336.80 5716.76 7671.59 3171.01
al enzyme ndria 07.3 OUSE G0000005 9048 3459 8856 6382 7687 2816 208 1323 695 6668 6698
subunit 9447
beta,
mitochondr
ial
Thioredoxi Prdx3 ENZ mitocho IPI001161 PRDX3_ P20108 ENSMUS 11757 0.54761 1.07 3 448.027 537.260 432.617 541.151 228.070 408.296 211.737 554.629 605.931 557.979
n- ndria 92.1 MOUSE G0000002 9048 3501 198 7537 4785 9246 4793 1062 12 9849 9583
dependent 4997
peroxide
reductase,
mitochondr
ial
Cytochrom Cox5a TP mitocho IPI001207 COX5A_ P12787 ENSMUS 12858 0.54761 0.85 4 1302.27 1505.10 1263.21 1721.26 517.597 1119.83 601.013 1298.02 1613.80 746.550
e c oxidase ndria 19.4 MOUSE G0000000 9048 7148 5905 5019 0261 5884 4451 7158 1987 6412 7223
subunit 5A, 0088
mitochondr
ial
NADH Ndufa6 TP mitocho IPI001333 NDUA6_ Q9CQZ5 ENSMUS 67130 0.54761 0.79 4 237.207 220.714 169.445 0 52.1621 101.083 28.4589 138.411 133.736 134.374
dehydrogen ndria 99.1 MOUSE G0000002 9048 1621 5731 3553 5 506 9912 5797 6984 9725
ase 2450
[ubiquinone
] 1 alpha
subcomplex
subunit 6
NADH- Ndufs1 ENZ mitocho IPI003088 NDUS1_ Q91VD9 ENSMUS 227197 0.54761 0.81 19 1126.56 1568.79 876.030 951.735 397.987 796.981 323.003 980.340 1154.02 753.327
ubiquinone ndria 82.5 MOUSE G0000002 9048 4325 2678 3205 8872 4944 7279 1775 6031 2965 1658
oxidoreduct 5968
ase 75 kDa
subunit,
mitochondr
ial
60 kDa heat Hspd1 CHA mitocho IPI003088 CH60_M P63038 ENSMUS 15510 0.54761 0.85 17 2350.42 3109.75 2013.42 2588.10 1051.99 1406.22 673.134 2512.29 2267.41 2532.10
shock ndria 85.6 OUSE G0000002 9048 5868 1818 8074 0306 5858 0808 1556 0394 7026 4171
protein, 5980
mitochondr
ial
Alpha-2- Ahsg DEV secreted IPI001282 FETUA_ P29699 ENSMUS 11625 0.54761 0.63 8 626.102 668.684 398.032 588.664 1960.71 830.428 268.837 475.832 628.973 451.534
HS- 49.1 MOUSE G0000002 9048 2397 3578 2621 729 1701 9311 7714 5917 7723 9856
glycoprotei 2868
n
Periostin Postn CS secreted IPI003390 POSTN_ Q62009 ENSMUS 50706 0.54761 0.59 9 229.325 179.013 612.480 209.014 308.662 220.256 93.2684 328.279 264.414 0
03.1 MOUSE G0000002 9048 8578 5593 0076 532 4584 287 3351 5283 0778
7750
Fibrinogen Fgg MOD secreted IPI009909 FIBG_M Q8VCM7 ENSMUS 99571 0.54761 0.97 9 358.200 571.207 483.379 0 409.737 619.083 285.907 348.546 353.022 168.733
gamma 97.1 OUSE G0000003 9048 9201 5979 7203 8744 9616 9801 2636 8557 7465
chain 3860
Flavin Blvrb ENZ IPI001139 BLVRB_ Q923D2 ENSMUS 233016 0.54761 1.22 8 545.419 1097.90 651.106 254.592 186.624 790.220 877.400 964.999 396.159 317.845
reductase 96.7 MOUSE G0000004 9048 3238 6493 1071 0738 337 3135 9933 7454 0297 1292
(NADPH) 0466
Protein Ahctf1 TP IPI001225 ELYS_M Q8CJF7 ENSMUS 226747 0.54761 0.40 5 378.029 5347.91 1273.40 1677.61 0 147.544 2121.18 270.693 177.643 797.033
ELYS 94.4 OUSE G0000002 9048 6678 9792 1502 6029 7615 9046 045 9422 3484
6491
Protein Mki67 UK IPI001249 E9PVX6_ Q7TSF6 ENSMUS 17345 0.54761 0.75 8 611.332 608.606 572.227 485.411 428.421 266.249 542.286 714.005 497.339 0
Mki67 (Ki- 59.2 MOUSE G0000003 9048 197 1326 0981 6193 5247 4246 9783 5161 1214

- 145 -
67 protein) 1004
Carbonyl Cbr1 ENZ IPI003141 CBR1_M P48758 ENSMUS 12408 0.54761 1.45 8 225.648 176.110 195.738 0 101.769 174.865 97.2868 303.051 252.399 184.273
reductase 91.6 OUSE G0000005 9048 031 123 1385 1252 5259 7646 6811 2184 9671
[NADPH] 1483
1
26S Psmd4 SIG IPI003457 PSMD4_ O35226 ENSMUS 19185 0.54761 0.87 1 494.437 651.683 400.307 669.224 248.148 395.065 187.722 653.285 613.956 286.816
proteasome 79.2 MOUSE G0000000 9048 077 6046 862 8136 8461 7851 6933 5458 107 2241
non- 5625
ATPase
regulatory
subunit 4
Histone H1f0 TF IPI004045 H10_MO Q8C1Y3 14958 0.54761 0.77 4 376.286 499.647 940.098 1220.86 825.084 400.350 295.442 562.320 999.244 710.896
H1.0 90.1 USE 9048 6219 2871 5975 5646 1445 8405 3783 8898 6817 6745
SH3 and Shank2 SCA IPI007570 SHAN2_ Q80Z38 ENSMUS 210274 0.54761 0.77 4 942.869 788.006 873.903 773.397 0 325.987 281.099 705.286 969.573 322.370
multiple 97.2 MOUSE G0000003 9048 7257 8913 3078 2613 7271 88 0144 7126 1911
ankyrin 7541
repeat
domains
protein 2
Cofilin-1 Cfl1 CS IPI008488 COF1_M P18760 12631 0.54761 0.91 4 388.954 475.362 627.769 0 458.392 285.148 128.536 334.869 665.810 353.236
16.1 OUSE 9048 5575 12 9926 9651 6112 6313 3642 2312 5988
E3 Rnf213 ENZ IPI008892 RN213_M E9Q555 ENSMUS 0.54761 1.43 10 504.208 346.548 122.688 418.314 0 76.6281 36.9201 596.680 835.388 447.189
ubiquitin- 05.3 OUSE G0000007 9048 1865 1141 3289 0827 385 6631 3683 0154 5004
protein 0327
ligase
RNF213
Mitogen- Map3k5 ENZ IPI008948 M3K5_M E9PWG9 ENSMUS 26408 0.54761 0.86 2 206.576 337.498 188.480 174.167 218.295 153.794 38.9044 179.286 327.133 273.827
activated 69.1 OUSE G0000007 9048 2003 4172 2034 6132 2243 9718 6294 2846 0058 9996
protein 1369
kinase
kinase
kinase 5
Neurobeach Nbeal1 UK IPI009707 E9PV03_ Q8BS04 ENSMUS 269198 0.54761 0.83 3 1556.16 1521.71 1031.92 2017.75 883.615 1218.36 724.530 1373.59 884.093 1643.92
in-like 64.1 MOUSE G0000007 9048 0315 3982 8105 5763 5223 4439 135 6351 667 5969
protein 1 3664
40S Rps20 RIB IPI009877 RS20_M P60867 ENSMUS 67427 0.54761 0.92 4 330.436 365.904 261.314 528.841 0 242.847 121.581 265.056 241.545 502.097
ribosomal 17.1 OUSE G0000002 9048 2205 5196 8234 1501 6848 8774 6383 7182 5455
protein S20 8234
Desmin Des CS muscle IPI001301 DESM_M P31001 ENSMUS 13346 0.59001 1.36 22 0 0 2855.49 0 1785.76 1380.78 998.906 1917.83 0 2016.36
02.4 OUSE G0000002 3887 3681 624 6489 4397 4523 7964
6208
Leucine Lrrc37a UK IPI007504 B1AWG4 B1AWG4 ENSMUS 0.59001 1.45 7 0 467.786 0 0 863.665 564.777 138.691 410.951 820.785 0
rich repeat 77.3 _MOUSE G0000007 3887 034 2818 9636 039 6814 6945
containing 8632
37A
E3 SUMO- Cbx4 ENZ IPI008169 CBX4_M O55187 ENSMUS 12418 0.59001 1.76 3 101.804 0 0 97.3899 0 51.8111 0 70.5484 163.468 65.2240
protein 80.1 OUSE G0000003 3887 8023 3272 1603 4221 5896 2345
ligase 9989
CBX4
Cytochrom Cox5b TP mitocho IPI007854 COX5B_ P19536 0.60040 0.85 6 1304.96 1267.26 1157.59 891.856 0 766.141 503.696 1046.15 1611.89 0
e c oxidase ndria 10.1 MOUSE 1848 8519 2915 2533 5842 3508 2601 7852 262
subunit 5B,
mitochondr
ial
Apolipopro Apoa4 TP secreted IPI003773 APOA4_ P06728 ENSMUS 11808 0.60040 0.60 13 656.894 1623.03 328.780 0 449.810 0 308.482 701.259 225.189 601.962
tein A-IV 51.3 MOUSE G0000003 1848 1813 7747 4333 1491 2923 0735 8758 9323

- 146 -
 2080
Granzyme Gzmf ENZ IPI001374 GRAF_M P08883 ENSMUS 14943 0.60040 0.70 4 244.175 314.159 113.154 0 179.657 218.535 0 293.113 38.6953 46.9177
F 96.1 OUSE G0000001 1848 0075 2008 1256 6243 097 6692 9448 6645
5441
60S acidic Rplp2 RIB IPI001397 RLA2_M P99027 ENSMUS 67186 0.60040 0.68 1 100.311 132.266 0 160.114 172.875 60.5159 32.7895 103.233 0 189.138
ribosomal 95.2 OUSE G0000002 1848 5843 4494 6818 3768 8271 4616 8339 3745
protein P2 5508
Putative Anp32c UK IPI004680 AN32C_ Q64G17 0.60040 0.71 2 175.064 226.405 133.717 0 28.1722 145.131 81.7299 146.156 0 27.4935
acidic 92.2 MOUSE 1848 3131 9604 2303 3775 5413 1025 7952 4908
leucine-rich
nuclear
phosphopro
tein 32
family
member C
Serine Sdsl ENZ IPI008580 SDSL_M D3Z0F6 ENSMUS 257635 0.60040 0.76 1 417.735 473.599 449.866 489.244 0 270.802 165.845 438.438 513.927 0
dehydratase 62.1 OUSE G0000002 1848 889 6663 195 2381 3217 914 3225 3347
-like 9596
Sideroflexi Sfxn1 TP mitocho IPI001154 SFXN1_ Q99JR1 ENSMUS 14057 0.60723 0.46 4 64.8521 0 89.5505 0 0 0 0 0 70.5054 0
n-1 ndria 54.3 MOUSE G0000002 5544 0515 9111 3723
1474
Methylmal Mut ENZ mitocho IPI001335 MUTA_ P16332 ENSMUS 17850 0.60723 1.67 2 124.455 0 0 0 0 0 0 54.4492 153.008 0
onyl-CoA ndria 53.2 MOUSE G0000002 5544 231 1248 6217
mutase, 3921
mitochondr
ial;
Short=MC
M;
EC=5.4.99.
2;
AltName:
Full=Methy
lmalonyl-
CoA
isomerase;
Flags:
Precursor;
Lon Lonp1 ENZ mitocho IPI007614 LONM_ Q8CGK3 ENSMUS 74142 0.60723 3.89 4 52.9798 0 0 0 0 0 0 42.0698 0 163.772
protease ndria 08.2 MOUSE G0000004 5544 8367 9919 7501
homolog, 1168
mitochondr
ial
NAD- Me2 ENZ mitocho IPI009876 MAOM_ Q99KE1 ENSMUS 107029 0.60723 0.37 2 204.104 0 56.7959 0 0 0 0 95.2665 0 0
dependent ndria 22.1 MOUSE G0000002 5544 1392 4412 2044
malic 4556
enzyme,
mitochondr
ial
39S Mrpl13 RIB mitocho IPI009883 RM13_M F7CXG9 ENSMUS 68537 0.60723 0.44 1 146.833 0 202.800 0 0 0 0 0 154.616 0
ribosomal ndria 16.1 OUSE G0000002 5544 8724 0703 8359
protein 2370
L13,
mitochondr
ial
Alpha-2- A2mp INH secreted IPI004540 A2MP_M Q6GQT1 ENSMUS 232345 0.60723 1.44 3 0 0 142.450 0 0 0 160.614 0 44.9123 0
macroglobu 52.2 OUSE G0000003 5544 6175 1899 5019
lin-P 0111

- 147 -
Haloacid Hdhd3 ENZ IPI001121 HDHD3_ Q9CYW4 ENSMUS 72748 0.60723 0.53 1 0 1063.04 0 0 2298.49 0 0 0 1797.01 0
dehalogena 28.1 MOUSE G0000003 5544 0799 2824 6628
se-like 8422
hydrolase
domain-
containing
protein 3
NACHT, Nlrp4c SIG IPI001181 NAL4C_ Q3TKR3 ENSMUS 83564 0.60723 1.39 2 182.491 0 0 0 0 0 32.2495 0 222.223 0
LRR and 21.3 MOUSE G0000003 5544 1787 4663 3802
PYD 4690
domains-
containing
protein 4C
Putative 311002 UK IPI001342 Q9CRV2_ Q9CRV2 0.60723 0.67 2 52.6778 0 321.637 0 0 0 0 249.222 0 0
uncharacter 1A11Ri 92.3 MOUSE 5544 3944 2222 8731
ized protein k
3110021A1
1Rik
Protein Fam161 UK IPI002282 F161B_M Q8CB59 ENSMUS 217705 0.60723 0.46 2 99.5221 0 37.2930 0 0 0 62.7774 0 0 0
FAM161B b 21.1 OUSE G0000002 5544 0288 2338 0656
1234
Adenosylho Ahcy ENZ IPI002304 SAHH_M P50247 ENSMUS 269378 0.60723 0.35 3 71.2258 0 0 278.736 0 0 0 0 0 121.307
mocysteina 40.6 OUSE G0000002 5544 4112 0555 1696
se 7597|ENS
MUSG00
00004808
7
Gamma- Sncg CS IPI002714 SYUG_M Q9Z0F7 ENSMUS 20618 0.60723 0.53 2 0 0 55.8253 0 162.091 0 0 0 0 114.733
synuclein 40.4 OUSE G0000002 5544 0295 8379 4937
3064
Phosphoino Pik3r5 MOD IPI003195 PI3R5_M Q5SW28 ENSMUS 320207 0.60723 1.50 1 0 0 40.0297 0 0 0 18.6874 0 41.5253 0
sitide 3- 64.5 OUSE G0000002 5544 0868 622 875
kinase 0901
regulatory
subunit 5
Tubulin Tubb2a CS IPI003380 TBB2A_ Q99J49 ENSMUS 22151 0.60723 0.26 10 0 0 696.479 0 2348.11 0 0 0 0 777.863
beta-2A 39.1 MOUSE G0000005 5544 7261 1646 5389
chain 8672
Utrophin Utrn CS IPI003534 E9Q6R7_ E9Q6R7 ENSMUS 22288 0.60723 2.54 4 0 0 0 157.119 0 254.212 0 145.021 0 0
20.7 MOUSE G0000001 5544 6263 8498 8227
9820
Envoplakin Evpl CS IPI004109 EVPL_M Q9D952 ENSMUS 14027 0.60723 0.39 2 45.8620 0 158.159 0 0 0 0 0 79.4094 0
54.2 OUSE G0000003 5544 3353 0633 8067
4282
Targeting Tpx2 CS IPI004204 TPX2_M A2APB8 ENSMUS 72119 0.60723 0.48 2 0 0 186.699 0 144.924 159.398 0 0 0 0
protein for 81.5 OUSE G0000002 5544 6628 2078 3933
Xklp2 7469
Lysine- Kdm2a TF IPI004537 KDM2A_ P59997 225876 0.60723 0.51 3 11.3739 0 0 302.647 0 0 158.872 0 0 0
specific 82.3 MOUSE 5544 3338 2965 4065
demethylas
e 2A
Plexin-D1 Plxnd1 RCP IPI004710 PLXD1_ Q3UH93 ENSMUS 67784 0.60723 1.74 2 0 0 109.597 0 0 70.2331 0 0 120.786 0
22.3 MOUSE G0000003 5544 2464 3609 2985
0123
Terminal Zcchc1 TF IPI006480 TUT4_M Q9EQN6 ENSMUS 230594 0.60723 1.50 3 0 0 0 0 130.661 12.3001 0 0 184.263 0
uridylyltran 1 42.1 OUSE G0000003 5544 1609 15 2622

- 148 -
sferase 4 4610
Ephrin Epha5 RCP IPI007539 E9PUQ0_ E9PUQ2 ENSMUS 0.60723 1.84 2 0 0 0 0 170.863 0 0 95.0833 0 219.940
type-A 51.2 MOUSE G0000002 5544 3382 5544 2156
receptor 5 9245
Methionine Mtr ENZ IPI007556 METH_M A6H5Y3 ENSMUS 238505 0.60723 2.14 2 0 197.772 0 0 0 0 0 269.546 152.715 0
synthase 05.2 OUSE G0000002 5544 1391 3122 6526
1311
Vacuolar Vps13c TP IPI007616 VP13C_ Q8BX70 ENSMUS 320528 0.60723 1.15 5 0 0 0 105.659 0 109.180 11.9148 0 0 0
protein 66.2 MOUSE G0000003 5544 7181 6812 3773
sorting- 5284
associated
protein 13C
Receptor- Ripk4 ENZ IPI008316 RIPK4_M D3YXY4 ENSMUS 72388 0.60723 1.75 2 0 683.728 0 0 0 394.144 0 802.381 0 0
interacting 12.1 OUSE G0000000 5544 4003 5291 0287
serine/threo 5251
nine-
protein
kinase 4
Unconventi Myo9a CS IPI008820 MYO9A_ Q8C170 ENSMUS 0.60723 0.32 2 607.934 158.855 0 0 0 0 0 0 0 245.773
onal 76.2 MOUSE G0000003 5544 5576 7769 898
myosin-Ixa 9585
Uncharacte UK IPI008961 K0825_M Q3UPC7 ENSMUS 72371 0.60723 2.47 2 0 0 95.4440 0 0 0 0 0 75.4304 159.839
rized 13.2 OUSE G0000007 5544 1607 0597 5236
protein 1252
KIAA0825
homolog
Protein Dlk2 MOD IPI009693 DLK2_M Q8K1E3 ENSMUS 106565 0.60723 2.08 1 0 0 0 0 148.050 0 0 125.229 182.123 0
delta 43.1 OUSE G0000004 5544 4153 3222 8986
homolog 2 7428
Potassium- Atp4a TP IPI009856 ATP4A_ Q91WH7 ENSMUS 0.60723 2.21 2 0 0 0 0 110.657 168.341 76.1393 0 0 0
transporting 04.1 MOUSE G0000000 5544 4003 1609 6352
ATPase 5553
alpha chain
1
Protein Kiaa031 TM IPI009859 K0317_M E9PZX5 ENSMUS 68497 0.60723 2.61 1 87.8551 0 0 0 0 71.8436 0 157.240 0 0
KIAA0317 7 45.1 OUSE G0000004 5544 6072 2805 8994
2350
Coiled-coil Cchcr1 DEV IPI010278 CCHCR_ Q3TWA2 0.60723 0.48 1 125.708 161.112 0 0 0 0 0 0 136.709 0
alpha- 42.1 MOUSE 5544 1565 1272 1215
helical rod
protein 1
NADH Ndufa1 TP mitocho IPI001167 NDUAA_ Q99LC3 ENSMUS 67273 0.65583 1.50 5 327.358 245.192 0 0 0 353.632 0 304.761 202.097 0
dehydrogen 0 ndria 48.1 MOUSE G0000002 6497 6563 871 4256 21 542
ase 6260
[ubiquinone
] 1 alpha
subcomplex
subunit 10,
mitochondr
ial
39S Mrpl12 RIB mitocho IPI001189 RM12_M Q9DB15 ENSMUS 56282 0.65583 0.47 2 45.8959 1048.67 0 0 0 66.8581 370.332 72.6427 0 0
ribosomal ndria 63.1 OUSE G0000003 6497 5967 8703 7637 939 1039
protein 9640
L12,
mitochondr
ial

- 149 -
RING Rspry1 UK secreted IPI008287 RSPRY_ Q8BVR6 ENSMUS 67610 0.65583 0.71 1 163.544 120.969 150.097 0 0 0 0 161.289 147.385 0
finger and 18.1 MOUSE G0000005 6497 141 5414 9417 1771 2301
SPRY 0079
domain-
containing
protein 1
Dynein Dnah5 CS IPI001282 DYH5_M Q8VHE6 ENSMUS 110082 0.65583 1.92 10 543.380 0 119.833 0 0 382.111 464.032 0 0 429.051
heavy chain 78.2 OUSE G0000002 6497 0434 8945 9438 3011 8217
5, 2262
axonemal
Nesprin-1 Syne1 CS IPI004039 SYNE1_ Q6ZWR6 ENSMUS 64009 0.65583 0.56 8 3571.37 0 3355.09 7738.76 0 0 4752.84 0 3471.40 0
93.5 MOUSE G0000001 6497 4582 6856 3366 7352 3014
9769
Spectrin Sptb CS IPI009878 SPTB1_M P15508 0.65583 1.06 20 190.471 130.926 172.269 0 0 0 464.293 58.5228 0 0
beta chain, 09.1 OUSE 6497 3311 0834 9748 7734 6972
erythrocyte
Protein 633044 UK IPI009898 E9Q502_ E9Q502 ENSMUS 0.65583 1.97 4 162.132 0 441.648 0 0 328.579 32.3359 0 0 825.762
6330444E1 4E15Ri 58.1 MOUSE G0000005 6497 3461 885 7973 4816 5321
5Rik k 1976
Lipoamide Dbt ENZ mitocho IPI001305 ODB2_M P53395 ENSMUS 13171 0.66643 0.72 11 211.743 231.784 193.411 0 0 0 51.0706 208.722 196.103 0
acyltransfer ndria 35.2 OUSE G0000000 0034 7283 0703 7216 901 8083 5751
ase 0340
component
of
branched-
chain
alpha-keto
acid
dehydrogen
ase
complex,
mitochondr
ial
Dimethylan Fmo4 ENZ IPI001282 FMO4_M Q8VHG0 ENSMUS 226564 0.66643 0.57 1 127.237 0 114.966 0 189.916 0 43.9204 134.143 66.7002 0
iline 88.3 OUSE G0000002 0034 9543 9726 435 4718 1549 0392
monooxyge 6692
nase [N-
oxide-
forming] 4
Coiled-coil Ccdc18 UK IPI004068 CCD18_ Q640L5 ENSMUS 73254 0.66643 0.65 4 0 976.638 0 725.019 611.300 552.597 195.084 753.101 0 0
domain- 30.5 MOUSE G0000005 0034 7583 7493 2331 0252 5698 469
containing 6531
protein 18
Apolipopro Apoo TP IPI006704 APOO_M Q9D186 ENSMUS 68316 0.66643 0.72 1 148.874 0 172.974 327.289 0 102.840 0 137.890 229.346 0
tein O 00.2 OUSE G0000007 0034 8624 8369 2873 0774 7943 5354
9508
LOC10004 Gm108 IGG IPI007538 A0A5E3_ A0A5E3 0.66643 0.67 3 302.346 0 332.554 0 423.869 0 169.219 341.476 197.001 0
6793 80 31.2 MOUSE 0034 956 4227 6508 9558 4301 3487
protein
Nebulin- Nrap CS IPI007852 NRAP_M Q80XB4 ENSMUS 18175 0.66643 0.86 2 0 317.737 195.049 201.987 0 113.326 0 315.131 187.725 0
related- 71.3 OUSE G0000004 0034 2118 8389 1835 7848 4675 1397
anchoring 9134|ENS
protein MUSG00
00009249
1
Inorganic Ppa1 ENZ IPI009886 IPYR_M E9Q5Z3 ENSMUS 67895 0.66643 0.72 1 125.708 161.112 128.859 0 0 69.1489 0 94.6017 136.709 0
pyrophosph 94.2 OUSE G0000002 0034 1565 1272 9664 29 9419 1215

- 150 -
atase 0089
Delta(3,5)- Ech1 ENZ mitocho IPI001308 ECH1_M O35459 ENSMUS 51798 0.67233 1.30 6 196.142 287.045 216.471 0 0 226.340 87.0533 200.033 394.062 0
Delta(2,4)- ndria 04.1 OUSE G0000005 5808 9606 0174 6828 6625 0668 3106 2124
dienoyl- 3898
CoA
isomerase,
mitochondr
ial
ATP Atp5f1 TP mitocho IPI003412 AT5F1_M Q9CQQ7 ENSMUS 11950 0.67233 1.74 5 127.775 206.745 148.388 0 0 320.300 115.750 41.2559 0 363.437
synthase ndria 82.2 OUSE G0000000 5808 605 4145 8003 6083 4504 0447 521
subunit b, 0563
mitochondr
ial
Organic Osta TP IPI001530 OSTA_M Q8R000 ENSMUS 106407 0.67233 0.63 1 0 894.093 856.108 360.267 0 222.212 164.397 759.907 0 180.427
solute 98.1 OUSE G0000003 5808 2329 6363 9478 3702 9136 4451 9512
transporter 5699
subunit
alpha
Ubiquitin- Ube2n ENZ IPI001658 UBE2N_ P61089 ENSMUS 93765 0.67233 0.91 1 43.9057 32.3580 40.7884 0 0 21.5707 22.1405 30.4156 0 32.3750
conjugating 54.3 MOUSE G0000007 5808 1312 6245 9761 782 5351 7946 9735
enzyme E2 4781
N
4933430I17 493343 UK IPI002220 Q8BHW4 Q8BHW4 ENSMUS 214106 0.67233 0.66 3 186.770 169.902 561.617 0 0 179.906 89.8697 165.611 169.456 0
Rik protein 0I17Rik 11.1 _MOUSE G0000005 5808 788 9701 6747 2297 2919 0804 7154
8046
Protein 493241 UK IPI002261 E9Q5W2_ Q8C5W2 ENSMUS 238663 0.67233 0.67 3 288.497 273.313 257.672 0 0 258.556 28.5975 87.6628 171.336 0
4932411G1 1G14Ri 08.2 MOUSE G0000004 5808 9091 6996 5529 2719 4368 483 9039
4Rik k 3986
Tropomyos Tpm1 TP muscle IPI008307 E9Q448_ E9Q448 ENSMUS 0.67517 1.13 16 2779.96 2728.43 3625.95 0 0 1971.62 765.108 2567.55 2597.06 2454.55
in alpha-1 04.1 MOUSE G0000003 3615 5539 3091 9492 9459 2384 4979 4387 3252
chain 2366
Rab Rabgap MOD IPI003395 RBG1L_ A6H6A9 ENSMUS 29809 0.67517 0.54 2 607.569 501.469 312.374 0 0 131.949 39.8577 187.032 250.907 156.474
GTPase- 1l 35.3 MOUSE G0000002 3615 0359 4452 3144 5033 8762 3976 0177 3349
activating 6721
protein 1-
like
Citrate Cs ENZ mitocho IPI001131 CISY_M Q9CZU6 ENSMUS 12974 0.69047 0.88 9 2609.26 3242.74 3197.55 3686.24 1520.39 2394.65 1516.07 3292.86 3674.03 1660.10
synthase, ndria 41.1 OUSE G0000000 619 5606 2612 2198 6725 6128 3342 8266 2436 8377 3364
mitochondr 5683
ial
Glutamate Glud1 ENZ mitocho IPI001142 DHE3_M P26443 ENSMUS 14661 0.69047 0.98 8 466.405 434.253 339.419 437.770 0 308.352 124.640 554.896 403.605 253.981
dehydrogen ndria 09.1 OUSE G0000002 619 4115 1561 0104 7812 5362 4585 581 7697 1919
ase 1, 1794
mitochondr
ial
Electron Etfa TP mitocho IPI001167 ETFA_M Q99LC5 ENSMUS 110842 0.69047 1.27 10 1169.56 1443.33 1446.15 1935.04 1116.75 2594.69 907.798 2478.28 1939.20 1097.03
transfer ndria 53.4 OUSE G0000003 619 6089 2492 5051 7236 5935 7261 457 4419 8642 5285
flavoprotei 2314
n subunit
alpha,
mitochondr
ial
Phosphate Slc25a3 TP mitocho IPI001247 MPCP_M Q8VEM8 ENSMUS 18674 0.69047 1.25 10 359.419 412.742 519.774 395.026 427.656 442.718 314.406 354.986 379.560 1159.27
carrier ndria 71.1 OUSE G0000006 619 4619 9346 4337 884 1564 7803 5151 1002 891 9504
protein, 1904
mitochondr

- 151 -
ial
ATP Atp5j TP mitocho IPI001254 ATP5J_M P97450 ENSMUS 11957 0.69047 1.02 1 45.7335 57.7629 83.0789 75.2038 64.8122 58.3364 40.4686 51.0377 62.0283 119.841
synthase- ndria 60.1 OUSE G0000002 619 5463 6645 0756 0392 8028 6312 7647 1521 0531 9574
coupling 2890
factor 6,
mitochondr
ial
NADH Ndufa4 TP mitocho IPI001259 NDUA4_ Q62425 ENSMUS 17992 0.69047 0.86 4 1717.22 2266.72 2023.80 2383.74 654.862 1417.81 755.096 1936.15 2567.36 1116.89
dehydrogen ndria 29.2 MOUSE G0000002 619 2111 8532 385 8284 5452 2289 4695 7745 0722 0965
ase 9632
[ubiquinone
] 1 alpha
subcomplex
subunit 4
Cytochrom Uqcrb TP mitocho IPI001323 QCR7_M Q9CQB4 ENSMUS 0.69047 0.79 9 666.483 823.641 679.283 756.043 406.389 473.672 157.202 840.897 798.633 363.184
e b-c1 ndria 47.1 OUSE G0000002 619 0822 204 2084 9306 7768 31 6213 2804 9574 4129
complex 1520
subunit 7
Cytochrom Cox6b1 ENZ mitocho IPI002253 CX6B1_ P56391 ENSMUS 110323 0.69047 0.82 5 456.291 578.838 751.368 1029.40 0 288.036 124.139 696.256 818.397 387.267
e c oxidase ndria 90.5 MOUSE G0000003 619 7045 2008 7424 7103 9865 596 032 0166 1937
subunit 6751
6B1
3- Hsd17b ENZ mitocho IPI003208 HCD2_M O08756 0.69047 1.36 5 186.303 178.736 90.5123 192.771 0 77.6642 113.587 267.218 296.381 128.626
hydroxyacy 10 ndria 47.10 OUSE 619 6576 6388 3909 1323 9921 2677 9147 9438 3312
l-CoA
dehydrogen
ase type-2
Prohibitin-2 Phb2 TF mitocho IPI003217 PHB2_M P67778 ENSMUS 12034 0.69047 0.88 10 747.728 849.183 547.868 337.264 0 400.019 210.828 521.803 595.771 453.191
ndria 18.4 OUSE G0000003 619 4409 0702 0032 6983 1281 7988 7023 9943 3603
8845|ENS
MUSG00
00000426
4
Malate Mdh2 ENZ mitocho IPI003235 MDHM_ P08249 ENSMUS 17448 0.69047 0.92 9 2977.32 3688.31 3013.16 3276.17 1814.09 2205.93 1517.21 2761.61 3975.69 3078.11
dehydrogen ndria 92.2 MOUSE G0000001 619 0474 2143 2649 9778 9306 0423 7778 7186 6264 8807
ase, 9179
mitochondr
ial
2,4- Decr1 ENZ mitocho IPI003873 DECR_M Q4FJK0 ENSMUS 67460 0.69047 0.85 3 570.339 651.683 400.307 669.224 248.148 419.899 187.722 653.285 613.956 286.816
dienoyl- ndria 79.1 OUSE G0000002 619 4922 6046 862 8136 8461 7171 6933 5458 107 2241
CoA 8223
reductase,
mitochondr
ial
NADH Ndufb8 TP mitocho IPI003874 NDUB8_ Q9D6J5 ENSMUS 67264 0.69047 1.06 3 195.190 384.776 263.348 143.036 69.0412 267.167 81.1731 311.958 297.595 163.204
dehydrogen ndria 30.1 MOUSE G0000002 619 4479 3257 7931 6557 0812 964 1352 0894 5436 7519
ase 5204
[ubiquinone
] 1 beta
subcomplex
subunit 8,
mitochondr
ial;
AltName:
Full=Comp
lex I-ASHI;
Short=CI-

- 152 -
ASHI;
AltName:
Full=NAD
H-
ubiquinone
oxidoreduct
ase ASHI
subunit;
Flags:
Precursor;
Fumarate Fh ENZ mitocho IPI007599 FUMH_M P97807 ENSMUS 14194 0.69047 0.84 7 1019.32 1135.95 931.437 1144.41 349.019 705.802 415.051 961.593 1308.48 467.341
hydratase, ndria 40.3 OUSE G0000002 619 2082 7418 6766 1588 9687 7094 6784 8615 2836 1334
mitochondr 6526
ial
Succinyl- Suclg1 ENZ mitocho IPI009863 SUCA_M Q9DBA3 ENSMUS 56451 0.69047 1.17 8 668.922 686.590 694.821 463.771 549.521 1167.59 246.722 850.298 1173.78 154.896
CoA ligase ndria 02.1 OUSE G0000005 619 1016 6564 3627 0512 8816 3703 1136 8757 9227 7138
[ADP/GDP 2738
-forming]
subunit
alpha,
mitochondr
ial
Fructose- Aldoa ENZ muscle IPI002214 ALDOA_ P05064 ENSMUS 11674 0.69047 1.07 13 2164.95 2683.16 1893.44 2052.63 2168.40 2895.06 1265.03 1792.93 1779.21 4001.45
bisphosphat 02.7 MOUSE G0000003 619 9174 4096 1857 0969 9639 9537 9487 9297 5445 4144
e aldolase 0695
A
Mast cell Mcpt4 ENZ muscle IPI007884 MCPT4_ Q3UN88 ENSMUS 17227 0.69047 1.09 4 183.692 90.5883 173.714 0 301.583 178.564 57.4047 206.963 192.343 183.614
protease 4 56.1 MOUSE G0000006 619 3952 4998 951 3367 0103 5561 4049 7977 7827
1068
Fibrinogen Fga CS secreted IPI001155 E9PV24_ Q99K47 ENSMUS 14161 0.69047 1.06 14 831.822 945.418 855.590 383.727 853.616 930.112 1012.60 723.765 856.628 564.967
alpha chain 22.3 MOUSE G0000002 619 0655 0085 7096 8691 4648 5704 3533 7621 2939 6479
8001
Peroxiredo Prdx2 ENZ IPI001179 PRDX2_ Q61171 ENSMUS 21672 0.69047 1.16 4 1500.93 1479.66 961.601 956.796 771.993 924.786 1811.17 1348.01 1527.08 939.876
xin-2 10.3 MOUSE G0000000 619 5992 4321 458 0207 0764 9761 5381 0214 612 3928
5161
Guanine Mcf2l MOD IPI004049 MCF2L_ Q8C474 ENSMUS 0.69047 0.98 1 310.400 391.997 323.193 255.051 0 235.583 141.239 310.486 373.551 199.847
nucleotide 68.1 MOUSE G0000003 619 2707 4157 3821 7784 1324 7815 3613 6787 2633
exchange 1442
factor DBS
Histone H4 Hist1h4 TF IPI004073 H4_MOU P62806 ENSMUS 10004123 0.69047 0.82 6 3584.03 4630.24 5224.09 3433.63 10452.3 3343.86 1918.25 4732.16 4833.22 7534.75
a 39.7 SE G0000006 0 619 5549 1433 1476 6298 6956 7071 897 8205 9019 4763
7455|ENS
MUSG00
00006885
1|ENSMU
SG000000
60093|EN
SMUSG0
00000692
66|ENSM
USG0000
0060678|E
NSMUSG
00000061
482|ENS
MUSG00
00006927

- 153 -
 4|ENSMU
SG000000
60981|EN
SMUSG0
00000606
39|ENSM
USG0000
0069305|E
NSMUSG
00000064
288|ENS
MUSG00
00006930
6|ENSMU
SG000000
91405
Phosphogly Pgam1 ENZ IPI004578 PGAM1_ Q9DBJ1 ENSMUS 18648 0.69047 1.10 7 774.749 744.748 722.980 530.036 294.596 710.801 367.051 661.937 803.599 838.682
cerate 98.3 MOUSE G0000001 619 1168 7739 0055 0982 7937 9837 3066 2411 211 5975
mutase 1 1752|ENS
MUSG00
00006910
6
Glutamine Glul ENZ IPI006267 GLNA_M P15105 ENSMUS 14645 0.69047 0.92 9 678.325 601.970 483.512 269.540 341.071 469.943 221.091 670.180 534.489 288.185
synthetase 90.3 OUSE G0000002 619 6951 4131 0935 3082 5367 1791 8974 7124 6232 3731
6473
High Hmgb1 TF IPI006656 HMGB1_ P63158 ENSMUS 10086225 0.69047 1.13 6 277.343 213.547 167.390 201.387 245.867 161.858 38.7581 321.930 359.407 363.266
mobility 01.1 MOUSE G0000006 8 619 3426 2554 299 044 689 9509 9273 9592 4889 3447
group 6551
protein B1
Family Fam170 UK IPI008486 Q08ED8_ E9PXT9 ENSMUS 105511 0.69047 1.36 1 184.371 205.791 309.446 133.563 0 388.041 172.379 381.351 135.048 59.9144
with b 57.2 MOUSE G0000007 619 6523 7063 4337 1739 6957 2331 433 6806 6754
sequence 8127
similarity
170,
member B
Cytochrom Uqcrq TP mitocho IPI002242 QCR8_M Q9CQ69 ENSMUS 22272 0.72408 3.74 4 132.795 0 127.900 0 0 377.730 0 597.607 0 0
e b-c1 ndria 10.5 OUSE G0000004 1661 3975 4985 2822 3267
complex 4894
subunit 8
Myosin Myl9 TP muscle IPI007505 MYL9_M Q9CQ19 ENSMUS 98932 0.72408 0.70 4 0 0 1148.51 977.567 0 0 0 724.669 764.604 0
regulatory 95.2 OUSE G0000006 1661 9718 7177 1435 5643
light 7818
polypeptide
9
Asporin Aspn CS secreted IPI001179 ASPN_M Q99MQ4 ENSMUS 66695 0.72408 0.54 2 135.271 0 176.377 0 0 0 51.2468 0 115.921 0
57.1 OUSE G0000002 1661 137 7092 3572 7317
1388
Matrix Mmp19 ENZ secreted IPI009440 MMP19_ Q3UW97 ENSMUS 58223 0.72408 0.65 1 0 97.4924 70.8488 0 0 46.7561 0 62.9846 0 0
metalloprot 72.1 MOUSE G0000002 1661 5903 6233 7092 9578
einase-19 5355
Cathepsin Ctsd ENZ IPI001110 CATD_M P18242 ENSMUS 13033 0.72408 0.88 3 292.207 284.252 0 0 0 0 0 247.206 258.037 0
D 13.1 OUSE G0000000 1661 6493 0487 4714 702
7891
4- Aldh9a ENZ IPI001243 AL9A1_ Q3UDG0 56752 0.72408 0.58 3 74.5574 0 0 0 71.6751 0 15.8796 68.9758 0 0
trimethyla 1 72.3 MOUSE 1661 1602 406 8589 4304
minobutyra
ldehyde

- 154 -
dehydrogen
ase
Peroxisoma Hsd17b ENZ IPI003316 DHB4_M P51660 ENSMUS 15488 0.72408 0.13 3 0 553.079 63.0645 0 0 33.7106 0 46.2090 0 0
l 4 28.5 OUSE G0000002 1661 171 8992 4883 9282
multifuncti 4507
onal
enzyme
type 2
FERM and Frmpd1 SCA IPI003407 FRPD1_ A2AKB4 ENSMUS 666060 0.72408 0.30 2 89.3180 0 189.280 0 0 0 22.1942 0 62.6888 0
PDZ 02.2 MOUSE G0000003 1661 2445 6006 8637 0625
domain- 5615
containing
protein 1
Integrin Itga8 CS IPI003451 ITA8_MO A2ARA8 ENSMUS 241226 0.72408 0.65 4 196.880 152.025 0 0 0 0 0 121.159 105.425 0
alpha-8 12.1 USE G0000002 1661 9384 4423 8967 0577
6768
Integrator Ints3 TF IPI003803 INT3_MO Q7TPD0 ENSMUS 229543 0.72408 0.61 2 214.314 225.702 0 0 0 0 127.333 0 0 140.899
complex 94.6 USE G0000002 1661 5539 0515 0677 2669
subunit 3 7933
Ubiquitin- Ube2j1 MOD IPI006482 UB2J1_M F6SPK0 ENSMUS 56228 0.72408 0.66 1 134.375 159.373 0 0 0 0 0 114.958 0 78.0232
conjugating 49.3 OUSE G0000002 1661 072 4274 3555 2804
enzyme E2 8277
J1
Tudor Tdrd5 DEV IPI007497 TDRD5_ Q5VCS6 214575 0.72408 1.48 2 101.239 0 100.237 0 0 180.761 0 117.856 0 0
domain- 74.4 MOUSE 1661 2596 3888 1216 9568
containing
protein 5
Calcium/cal Camkk2 ENZ IPI008746 KKCC2_ E9QQ88 ENSMUS 207565 0.72408 1.65 1 0 56.6485 66.7470 0 0 0 0 106.897 96.1477 0
modulin- 30.1 MOUSE G0000002 1661 5278 9304 5869 6429
dependent 9471
protein
kinase
kinase 2
Probable Jmjd1c TF IPI010086 JHD2C_ E9QPL3 ENSMUS 108829 0.72408 0.19 2 100.340 0 497.555 0 0 0 59.6092 0 0 52.3080
JmjC 73.1 MOUSE G0000003 1661 9558 1286 8241 7589
domain- 7876
containing
histone
demethylati
on protein
2C
Antithromb Serpinc INH secreted IPI001366 ANT3_M P32261 ENSMUS 11905 0.75329 1.06 6 155.517 68.4953 72.4565 98.3629 0 39.1036 105.204 102.637 169.664 0
in-III 1 42.1 OUSE G0000002 8033 8683 427 634 3945 9527 805 3824 365
6715
Bactericidal Bpi SIG secreted IPI007577 BPI_MO Q67E05 ENSMUS 329547 0.75329 0.76 4 158.549 98.2778 149.255 98.8772 0 26.0521 0 132.824 199.010 26.5471
permeabilit 49.1 USE G0000005 8033 54 1337 7686 0363 6086 7812 8769 2201
y- 2922
increasing
protein
Alstrom Alms1 TP IPI001702 ALMS1_ Q8K4E0 ENSMUS 236266 0.75329 0.90 3 65.2608 113.160 113.661 134.630 0 92.4220 0 88.2146 67.1777 134.194
syndrome 05.4 MOUSE G0000006 8033 1012 2411 0079 078 4793 4096 0788 6132
protein 1 3810
homolog
Spermatid Strbp DEV IPI004751 STRBP_ Q91WM1 ENSMUS 20744 0.75329 0.76 3 207.131 0 171.768 400.858 221.216 136.637 115.269 283.164 229.994 0
perinuclear 77.4 MOUSE G0000002 8033 746 9228 7136 4266 9029 6764 1436 2045
RNA- 6915

- 155 -
binding
protein
NADH Ndufv3 TP mitocho IPI001282 Q91WP8_ Q91WP8 0.79716 1.04 3 27.3019 0 13.1591 0 0 0 0 0 42.1628 0
dehydrogen ndria 85.1 MOUSE 9693 5228 7067 863
ase
[ubiquinone
]
flavoprotei
n 3,
mitochondr
ial
Methyltrans Mettl17 ENZ mitocho IPI006050 MET17_ Q3U2U7 ENSMUS 52535 0.79716 0.23 1 0 0 168.258 0 0 15.9872 0 0 0 23.1800
ferase-like ndria 62.5 MOUSE G0000000 9693 8875 8062 5695
protein 17, 4561
mitochondr
ial
Heat shock Trap1 CHA mitocho IPI009874 TRAP1_ F6YP65 ENSMUS 68015 0.79716 0.97 8 393.747 0 0 0 0 248.325 0 0 133.607 0
protein 75 ndria 41.1 MOUSE G0000000 9693 8809 9869 0853
kDa, 5981
mitochondr
ial
Tropomyos Tpm4 CS muscle IPI004212 TPM4_M Q6IRU2 ENSMUS 326618 0.79716 0.99 6 0 0 229.706 0 0 168.388 59.0059 0 0 0
in alpha-4 23.3 OUSE G0000003 9693 6256 6048 5487
chain 1799
Troponin T, Tnnt2 CS muscle IPI008289 TNNT2_ P50752 ENSMUS 21956 0.79716 1.26 3 0 0 522.542 0 0 241.001 0 419.346 0 0
cardiac 18.1 MOUSE G0000002 9693 9301 2345 1775
muscle 6414
Collagen Col27a1 CS secreted IPI004084 CORA1_ Q5QNQ9 ENSMUS 373864 0.79716 0.84 3 54.8117 0 22.6131 0 0 0 0 65.0785 0 0
alpha- 91.4 MOUSE G0000004 9693 9958 2137 9172
1(XXVII) 5672
chain
Peroxidasin Pxdn ENZ secreted IPI004613 PXDN_M Q3UQ28 ENSMUS 69675 0.79716 1.45 2 0 204.470 0 0 0 0 0 0 188.221 107.642
homolog 84.6 OUSE G0000002 9693 234 6595 6167
0674
Secretogran Scg2 SIG secreted IPI006080 SCG2_M Q4W8U9 ENSMUS 20254 0.79716 1.36 1 0 0 53.9237 0 0 53.2613 20.1524 0 0 0
in-2 95.1 OUSE G0000005 9693 1386 1614 7518
0711
Apolipopro Apool UK secreted IPI008287 APOOL_ B1AV14 ENSMUS 68117 0.79716 0.64 4 124.149 0 125.489 0 0 0 0 0 159.715 0
tein O-like 58.2 MOUSE G0000002 9693 981 6612 343
5525
Synaptotag Syt13 TP IPI001115 SYT13_M Q9EQT6 ENSMUS 80976 0.79716 0.73 1 392.608 0 0 0 0 0 103.868 0 183.372 0
min-13 20.4 OUSE G0000002 9693 7155 3976 9395
7220
Proteasome Psmb1 ENZ IPI001138 PSB1_M O09061 ENSMUS 19170 0.79716 1.14 1 53.4915 0 0 0 0 31.7562 29.1778 0 0 0
subunit 45.1 OUSE G0000001 9693 8121 3949 0601
beta type-1 4769
Glutathione Gsto1 ENZ IPI001142 GSTO1_ O09131 ENSMUS 14873 0.79716 1.55 3 74.6053 0 64.8947 0 0 0 0 0 0 216.121
S- 85.1 MOUSE G0000002 9693 2961 7311 7691
transferase 5068
omega-1
Biglycan Bgn CS IPI001231 PGS1_M P28653 ENSMUS 12111 0.79716 0.75 2 0 0 0 0 236.768 93.4573 0 0 84.0824 0
94.1 OUSE G0000003 9693 8884 2865 4214
1375
Ubiquitin- Uba1 ENZ IPI001233 UBA1_M Q02053 ENSMUS 22201 0.79716 0.60 9 257.247 0 240.303 0 0 0 0 0 299.470 0
like 13.1 OUSE G0000000 9693 1553 0701 907
modifier- 1924

- 156 -
activating
enzyme 1
Scm-like Sfmbt1 UK IPI001255 SMBT1_ Q9JMD1 ENSMUS 54650 0.79716 0.98 2 0 0 210.440 0 0 68.7041 0 0 138.035 0
with four 11.1 MOUSE G0000000 9693 6104 6353 074
MBT 6527
domains
protein 1
Plasma Atp2b2 TP IPI001277 AT2B2_ Q9R0K7 ENSMUS 11941 0.79716 0.57 2 243.270 207.967 0 0 0 0 0 258.749 0 0
membrane 13.1 MOUSE G0000003 9693 6036 8883 8492
calcium- 0302
transporting
ATPase 2
Zinc finger Zfp292 TF IPI001314 ZN292_M Q9Z2U2 ENSMUS 30046 0.79716 0.60 4 0 0 409.452 0 0 84.6929 0 0 161.284 0
protein 292 08.10 OUSE G0000003 9693 1422 9765 9726
9967
ATP- Kcnj14 CNL IPI001703 IRK14_M Q8JZN3 ENSMUS 211480 0.79716 0.82 1 162.897 196.949 0 0 0 0 0 0 296.520 0
sensitive 49.1 OUSE G0000005 9693 5429 3341 458
inward 8743
rectifier
potassium
channel 14
Zinc finger Zc2hc1 TF IPI002223 ZC21A_ Q8BJH1 ENSMUS 67306 0.79716 0.76 1 35.9245 91.3824 0 0 0 0 0 0 96.9303 0
C2HC a 93.2 MOUSE G0000004 9693 9215 5564 1978
domain- 3542
containing
protein 1A
Ras-related Rab5c TP IPI002245 RAB5C_ P35278 ENSMUS 19345 0.79716 0.43 3 0 0 187.076 0 0 0 0 36.8844 42.7372 0
protein 18.2 MOUSE G0000001 9693 4982 1296 3485
Rab-5C 9173
D- Ddt ENZ IPI002300 DOPD_M O35215 ENSMUS 13202 0.79716 0.76 2 71.7395 0 0 0 76.4372 112.232 0 0 0 0
dopachrom 34.5 OUSE G0000000 9693 406 6471 974
e 1666
decarboxyl
ase
Cysteine- Crip1 TP IPI002624 CRIP1_M P63254 ENSMUS 12925 0.79716 0.39 2 0 0 0 0 100.526 18.2044 0 20.7867 0 0
rich protein 88.9 OUSE G0000000 9693 6976 77 6797
1 6360
Scavenger Scara3 TM IPI003130 SCAR3_ Q8C850 ENSMUS 219151 0.79716 0.62 3 0 869.854 0 0 0 0 41.8003 499.333 0 0
receptor 25.4 MOUSE G0000003 9693 4701 6474 4679
class A 4463
member 3
Dimethylan Fmo2 ENZ IPI003222 FMO2_M Q8K2I3 ENSMUS 55990 0.79716 1.29 2 32.6199 26.7303 0 0 0 0 0 76.4027 0 0
iline 45.3 OUSE G0000004 9693 3213 7188 8887
monooxyge 0170
nase [N-
oxide-
forming] 2
Golgin Golga1 CS IPI003370 GOGA1_ Q9CW79 ENSMUS 76899 0.79716 2.15 3 93.0206 0 90.7941 0 0 0 0 0 0 395.460
subfamily 03.1 MOUSE G0000002 9693 4855 3435 6547
A member 6754
1
Autophagy- Atg2b UK IPI003779 ATG2B_ Q80XK6 ENSMUS 76559 0.79716 0.37 3 0 0 0 0 998.308 130.527 0 0 0 241.876
related 25.2 MOUSE G0000004 9693 2737 8069 0096
protein 2 1341
homolog B
Hyaluronan Hmmr RCP IPI004662 HMMR_ Q00547 ENSMUS 15366 0.79716 0.48 2 1145.33 0 0 0 0 395.707 153.406 0 0 0

- 157 -
mediated 19.3 MOUSE G0000002 9693 8693 8911 3858
motility 0330
receptor
Guanine Gnas SIG IPI004697 GNAS1_ Q6R0H7 ENSMUS 14683 0.79716 0.99 3 0 0 0 762.002 0 397.640 0 0 0 357.454
nucleotide- 93.3 MOUSE G0000002 9693 8653 0458 2002
binding 7523
protein G(s)
subunit
alpha
isoforms
Xlas
Dynein Dnahc9 CS IPI004739 B1AR51_ B1AR51 ENSMUS 237806 0.79716 0.85 2 280.050 0 0 0 0 0 21.5804 0 216.940 0
heavy chain 70.2 MOUSE G0000005 9693 8602 6571 9355
9, 6752
axonemal
Selenium- Selenbp TP IPI006238 SBP1_M P17563 ENSMUS 20341 0.79716 0.55 6 313.311 0 371.278 0 0 0 0 374.555 0 0
binding 1 45.3 OUSE G0000006 9693 915 8769 2965
protein 1 8874
Partitioning Pard6a SCA IPI006482 PAR6A_ Q9Z101 ENSMUS 56513 0.79716 1.27 1 580.449 0 0 0 0 516.700 219.524 0 0 0
defective 6 97.1 MOUSE G0000000 9693 6064 6211 6849
homolog 5699
alpha
Protein FAM18 UK IPI006662 F186A_M Q3V0D7 ENSMUS 72277 0.79716 0.92 4 0 0 341.441 0 0 252.482 0 0 62.5256 0
FAM186A 6A 28.4 OUSE G0000004 9693 0021 8924 8064
5350
Tyrosine- Ptpn13 ENZ IPI007504 PTN13_M Q3TTT8 19249 0.79716 0.56 4 549.905 0 0 0 0 0 71.6457 0 0 237.222
protein 72.3 OUSE 9693 4148 5006 9984
phosphatas
e non-
receptor
type 13
Protein Cbfa2t2 TF IPI007512 MTG8R_ F6QMQ3 ENSMUS 12396 0.79716 0.90 1 204.238 0 0 0 0 0 64.5209 118.426 0 0
CBFA2T2 15.1 MOUSE G0000003 9693 2328 0859 614
(Core- 8533
binding
factor, runt
domain,
alpha
subunit 2,
translocated
to, 2
(Human))
Sperm Gm716 ENZ IPI007552 SMKY_M A0AUV4 ENSMUS 635895 0.79716 0.63 2 159.121 143.906 0 0 0 0 0 0 190.000 0
motility 8 24.2 OUSE G0000006 9693 1856 9843 1189
kinase Y 7941
Cytosol Lap3 ENZ IPI008284 AMPL_M Q9CPY7 ENSMUS 66988 0.79716 1.42 2 53.1615 0 0 0 0 0 31.8663 43.5997 0 0
aminopepti 69.1 OUSE G0000003 9693 9635 9125 1244
dase 9682
E3 Ubr3 ENZ IPI008285 UBR3_M Q5U430 ENSMUS 68795 0.79716 0.84 4 0 0 0 0 2555.30 931.278 0 0 0 1205.98
ubiquitin- 33.2 OUSE G0000004 9693 873 5083 5314
protein 4308
ligase
UBR3
Dynein CS IPI008496 F6QYG9_ F6QYG9 ENSMUS 0.79716 0.74 9 1789.70 0 0 0 0 415.709 0 900.402 0 0
heavy chain 64.3 MOUSE G0000006 9693 6123 3913 0698
7, 7440|ENS
axonemal MUSG00

- 158 -
 00007859
5
Serine/thre Cdc42b ENZ IPI008497 MRCKG_ Q80UW5 ENSMUS 240505 0.79716 0.82 3 594.972 0 0 0 0 152.268 0 0 335.346 0
onine- pg 60.1 MOUSE G0000002 9693 0711 5844 8241
protein 4769
kinase
MRCK
gamma
Zinc finger Znf609 TF IPI008761 ZN609_M E9Q1Y2 ENSMUS 214812 0.79716 2.04 2 0 0 5.20061 0 64.1696 0 0 0 0 141.279
protein 609 35.1 OUSE G0000004 9693 6932 9062 6532
0524
Intraflagell Ift81 DEV IPI008813 IFT81_M D3Z5A8 ENSMUS 12589 0.79716 1.08 2 0 78.5403 0 0 0 53.2613 31.2672 0 0 0
ar transport 52.2 OUSE G0000002 9693 06 1614 102
protein 81 9469
homolog
UPF0606 Kiaa154 TM IPI008860 K1549_M F7ATU7 ENSMUS 330286 0.79716 0.08 1 0 0 0 0 525.638 25.4561 19.0035 0 0 0
protein 9 09.3 OUSE G0000006 9693 5357 6496 4087
KIAA1549 3455
Myopalladi Mypn CS IPI009298 MYPN_M Q5DTJ9 ENSMUS 68802 0.79716 0.64 1 537.688 0 0 0 0 166.128 0 176.524 0 0
n 15.1 OUSE G0000002 9693 3062 978 4265
0067
Tau-tubulin Ttbk1 ENZ IPI009385 TTBK1_ Q6PCN3 ENSMUS 106763 0.79716 0.66 2 0 172.553 173.271 0 0 0 0 0 228.275 0
kinase 1 23.1 MOUSE G0000001 9693 3595 3785 3899
5599
Shugoshin- Sgol2 CC IPI009683 SGOL2_ Q7TSY8 ENSMUS 68549 0.79716 8.59 2 0 66.2637 0 99.3903 0 0 0 1423.01 0 0
like 2 13.1 MOUSE G0000002 9693 2369 3435 6671
6039
Cholecysto Cckar RCP IPI009893 CCKAR_ Q3TPL0 ENSMUS 12425 0.79716 1.08 1 0 0 251.508 0 0 0 58.2461 0 214.009 0
kinin 43.1 MOUSE G0000002 9693 1804 3487 7953
receptor 9193
type A
GrpE Grpel1 CHA mitocho IPI001170 GRPE1_ Q99LP6 ENSMUS 17713 0.82366 0.94 6 125.496 112.447 85.8588 0 0 0 0 101.740 202.775 0
protein ndria 83.1 MOUSE G0000002 4389 9276 8581 2606 3463 4332
homolog 1, 9198
mitochondr
ial
Ubiquinone Coq7 ENZ mitocho IPI001255 COQ7_M P97478 ENSMUS 12850 0.82366 1.34 1 73.7500 57.1834 0 0 0 52.7807 0 58.0978 64.1491 0
biosynthesi ndria 92.1 OUSE G0000003 4389 2591 5169 8777 9311 3173
s protein 0652
COQ7
homolog
NADH Ndufb3 TP mitocho IPI001334 NDUB3_ Q9CQZ6 ENSMUS 66495 0.82366 0.62 4 155.567 233.737 155.344 0 0 0 0 171.838 165.191 0
dehydrogen ndria 03.1 MOUSE G0000002 4389 3829 2895 1558 92 4479
ase 6032
[ubiquinone
] 1 beta
subcomplex
subunit 3;
AltName:
Full=Comp
lex I-B12;
Short=CI-
B12;
AltName:
Full=NAD
H-
ubiquinone

- 159 -
oxidoreduct
ase B12
subunit;
Short Trpc4 CNL IPI002297 TRPC4_ Q9QUQ5 ENSMUS 22066 0.82366 0.86 3 0 62.9077 170.704 0 0 0 75.7927 0 59.0776 67.0141
transient 45.1 MOUSE G0000002 4389 2284 3286 6962 5967 6253
receptor 7748
potential
channel 4
Dehydroge Dhrs4 ENZ IPI003187 DHRS4_ Q99LB2 0.82366 0.85 5 58.4543 0 280.202 144.638 0 0 176.974 0 0 235.263
nase/reduct 50.5 MOUSE 4389 0701 7705 7577 6706 6861
ase SDR
family
member 4
Elongation Eef1g TF IPI003188 EF1G_M Q9D8N0 ENSMUS 67160 0.82366 3.27 5 0 132.047 218.797 0 0 80.1059 0 88.7000 0 977.556
factor 1- 41.4 OUSE G0000007 4389 8445 3923 8136 6518 3129
gamma 1644
UDP- B3gnt7 ENZ IPI004677 B3GN7_ A0PJH7 ENSMUS 227327 0.82366 0.80 3 161.854 0 88.0657 0 63.8078 180.711 0 0 68.7697 0
GlcNAc:bet 12.5 MOUSE G0000007 4389 71 9642 4304 5282 575
aGal beta- 9445
1,3-N-
acetylgluco
saminyltran
sferase 7
Neurofilam Nefl CS IPI005549 NFL_MO P08551 ENSMUS 18039 0.82366 1.28 4 0 0 1218.05 0 575.282 366.489 0 889.705 1043.61 0
ent light 28.3 USE G0000002 4389 7915 8213 2328 5568 7732
polypeptide 2055
RILP-like Rilpl2 CS IPI008855 RIPL2_M Q99LE1 ENSMUS 80291 0.82366 1.45 1 0 203.096 243.585 0 0 120.340 0 122.885 0 403.684
protein 2 68.1 OUSE G0000002 4389 5124 073 7865 9316 4332
9401
Membrane- Magi3 SCA IPI008947 MAGI3_ Q9EQJ9 ENSMUS 99470 0.82366 0.77 3 468.589 257.680 534.487 0 0 0 0 426.763 539.089 0
associated 55.1 MOUSE G0000005 4389 324 0323 3688 5061 9873
guanylate 2539
kinase,
WW and
PDZ
domain-
containing
protein 3
Gamma- Aph1b SIG IPI009752 APH1B_ F8WHK7 ENSMUS 208117 0.82366 2.08 1 89.2499 0 0 78.1156 0 0 71.9364 60.8386 0 216.121
secretase 35.1 MOUSE G0000003 4389 0918 2816 7235 9606 7691
subunit 2375
APH-1B
Glutathione Gstp1 ENZ IPI009905 GSTP1_ F8WJD9 ENSMUS 14870 0.82366 0.29 2 0 0 26.2890 252.433 0 18.8541 0 0 29.0684 32.3132
S- 29.1 MOUSE G0000006 4389 2705 6785 6768 7209 7879
transferase 0803
P1
Short/branc Acadsb ENZ mitocho IPI001198 ACDSB_ Q9DBL1 ENSMUS 66885 0.82935 0.88 5 0 157.933 204.893 225.905 0 119.357 0 182.371 219.202 0
hed chain ndria 42.1 MOUSE G0000003 6961 2039 7608 8436 5041 0881 8458
specific 0861
acyl-CoA
dehydrogen
ase,
mitochondr
ial
Kelch-like Klhl17 CS IPI003788 KLH17_ Q6TDP3 ENSMUS 231003 0.82935 1.17 3 0 0 24940.8 44222.5 19466.7 25788.5 43376.8 34469.5 0 0
protein 17 08.4 MOUSE G0000007 6961 0427 2438 2121 3263 2058 9226
8484

- 160 -
Cytosolic Agbl5 ENZ IPI004578 CBPC5_ Q09M02 ENSMUS 231093 0.82935 0.91 2 0 333.224 412.818 0 415.405 454.710 0 288.986 313.700 0
carboxypep 26.5 MOUSE G0000002 6961 773 595 7607 4495 0802 8613
tidase-like 9165
protein 5
E1A- Ep400 ENZ IPI007201 EP400_M Q8CHI8 ENSMUS 75560 0.82935 0.77 3 895.893 33.0783 739.356 0 0 0 85.5392 594.678 600.697 0
binding 44.2 OUSE G0000002 6961 2748 0613 5536 0061 0679 859
protein 9505
p400
Protein Gm340 UK IPI009859 F6RGI3_ F6RGI3 ENSMUS 0.82935 1.96 3 0 19.8682 22.9780 38.7565 0 0 100.416 0 36.7028 22.8283
Gm340 22.1 MOUSE G0000009 6961 2351 4374 3384 0897 8426 3757
0673
Propionyl- Pcca ENZ mitocho IPI003305 PCCA_M Q91ZA3 ENSMUS 110821 0.83251 0.83 17 683.412 474.262 504.695 0 0 296.917 124.113 378.674 573.328 0
CoA ndria 23.1 OUSE G0000004 8813 1667 8222 0689 9377 0772 8237 3532
carboxylase 1650
alpha chain,
mitochondr
ial
ProSAAS Pcsk1n MOD secreted IPI001356 PCSK1_ Q9QXV0 ENSMUS 30052 0.83251 0.80 1 87.6148 45.1175 41.6337 76.2108 0 0 80.1054 56.4011 63.4782 0
04.5 MOUSE G0000003 8813 5682 3795 0148 0473 019 7913 4737
9278
pre-mRNA Wdr33 TF IPI001702 WDR33_ Q8K4P0 ENSMUS 74320 0.83251 1.01 3 1111.65 1208.06 1097.86 0 0 742.581 494.888 1038.77 1172.91 0
3' end 42.1 MOUSE G0000002 8813 2821 4607 8862 8811 45 0857 5239
processing 4400
protein
WDR33
cAMP- Prkar2b MOD IPI002245 KAP3_M P31324 ENSMUS 19088 0.83251 0.90 4 62.5625 66.9226 80.5978 82.4530 0 46.3223 0 80.6163 136.104 0
dependent 70.3 OUSE G0000000 8813 635 6926 9129 147 5648 5903 9064
protein 2997
kinase type
II-beta
regulatory
subunit
Spectrin Spta1 CS IPI003232 SPTA1_ P08032 ENSMUS 20739 0.83251 0.85 31 334.069 547.266 353.250 0 217.999 0 742.095 435.945 62.4952 0
alpha chain, 30.6 MOUSE G0000002 8813 6666 3673 7839 704 7137 4459 2632
erythrocyte 6532
Protein Kndc1 MOD IPI003803 VKIND_ Q0KK55 ENSMUS 76484 0.83251 0.74 3 130.655 255.294 102.550 0 0 53.0978 50.6746 93.6172 161.974 0
very KIND 21.7 MOUSE G0000006 8813 7689 7175 8056 0574 2296 4439 2627
6129
Early Eea1 TP IPI004537 EEA1_M Q8BL66 ENSMUS 216238 0.83251 1.07 5 1025.41 876.863 730.336 0 572.303 804.333 0 1250.28 1366.77 0
endosome 76.1 OUSE G0000003 8813 3783 6306 5561 5494 8167 1508 415
antigen 1 6499
Fibroblast Fgfr2 ENZ IPI008954 FGFR2_ E9PX60 ENSMUS 14183 0.83251 0.93 2 528.290 67.9018 585.917 0 288.490 250.097 396.815 0 0 717.643
growth 29.1 MOUSE G0000003 8813 4002 998 5178 9967 2662 8446 8834
factor 0849
receptor 2
Supervillin Svil CS IPI009180 SVIL_M Q8K4L2 ENSMUS 225115 0.83251 0.61 8 255.726 0 0 350.570 569.482 473.580 23.1205 57.2905 0 161.798
64.1 OUSE G0000002 8813 4547 0724 0836 1697 3925 1155 0058
4236
Protein Gm238 UK IPI009862 G3UY53_ G3UY53 ENSMUS 0.83251 1.22 2 151.102 0 138.476 0 118.075 87.6624 85.8081 180.968 143.324 0
Gm2381 1 40.1 MOUSE G0000009 8813 6408 9046 6256 9668 6154 0507 3379
2225
GTP- Ran TP IPI001271 RAN_MO Q14AA6 ENSMUS 10004599 0.83403 1.03 4 182.759 266.815 284.889 0 0 85.9473 126.372 159.078 134.165 252.630
binding 09.4 USE G0000002 9 523 4226 728 114 0693 018 3998 7716 2354
nuclear 8287|ENS
protein Ran MUSG00
00002943

- 161 -
 0
Golgin Golga4 TP IPI001388 GOGA4_ Q91VW5 ENSMUS 54214 0.83403 1.07 3 236.179 78.7043 90.9154 0 0 57.6527 62.2332 156.906 106.662 51.7113
subfamily 60.3 MOUSE G0000003 523 2943 507 5431 6922 4137 1665 8152 8707
A member 8708
4
Potassium Kcnk4 CNL IPI003196 KCNK4_ O88454 ENSMUS 16528 0.83403 1.11 1 0 710.145 0 2282.19 1551.47 696.047 166.201 1867.87 1024.33 1304.07
channel 53.3 MOUSE G0000002 523 9127 1752 4749 4963 149 447 3131 1266
subfamily 4957
K member
4
Transitional Vcp ENZ IPI006222 TERA_M Q01853 ENSMUS 269523 0.83403 0.96 8 464.493 153.821 348.848 0 0 149.291 194.021 165.895 227.533 189.925
endoplasmi 35.5 OUSE G0000002 523 3393 1696 6137 2334 2955 7225 6363 0814
c reticulum 8452
ATPase
Electroneut Slc4a8 TP IPI008901 S4A8_M Q8JZR6 ENSMUS 59033 0.83403 0.83 2 0 0 198.609 213.235 137.873 88.5162 52.2140 77.8897 69.6842 166.183
ral sodium 44.1 OUSE G0000002 523 5642 8911 7278 4258 7667 2268 0757 0916
bicarbonate 3032
exchanger 1
Heat shock Hsf4 TF IPI009907 HSF4_M Q3UG93 ENSMUS 26386 0.83403 0.82 4 348.193 181.308 220.844 0 0 46.5257 61.0083 141.698 179.486 188.188
factor 10.1 OUSE G0000003 523 3829 6318 2173 1144 9442 2025 5706 3121
protein 4 3249
Superoxide Sod2 ENZ mitocho IPI001091 SODM_M P09671 ENSMUS 20656 0.84126 1.09 7 961.440 1174.29 1301.84 1173.23 360.374 1013.75 757.661 1426.63 1431.70 782.304
dismutase ndria 09.1 OUSE G0000000 9841 9083 7663 6616 5837 6094 1517 7097 9906 6444 0869
[Mn], 6818
mitochondr
ial
Electron Etfb TP mitocho IPI001214 ETFB_M Q9DCW4 ENSMUS 110826 0.84126 0.92 12 4465.87 5508.51 3722.10 4179.21 1426.44 3418.83 1588.62 5129.22 5265.08 2360.31
transfer ndria 40.4 OUSE G0000000 9841 7805 2607 1222 7579 3885 4921 9935 091 1436 7119
flavoprotei 4610
n subunit
beta
Isocitrate Idh3b ENZ mitocho IPI001266 Q91VA7_ Q91VA7 ENSMUS 170718 0.84126 1.07 16 2182.05 2150.50 1191.79 1623.75 0 1453.91 833.916 2411.40 2292.79 656.674
dehydrogen ndria 35.1 MOUSE G0000002 9841 2457 5569 1929 5881 0878 3454 8944 7353 9449
ase [NAD] 7406
subunit
beta,
mitochondr
ial
Mitochondr Slc25a2 TP mitocho IPI001315 MCAT_M Q9Z2Z6 ENSMUS 57279 0.84126 0.82 9 838.418 952.273 738.431 869.453 335.978 600.530 268.167 884.863 960.907 362.231
ial 0 ndria 84.1 OUSE G0000003 9841 1112 7447 6711 865 0356 6497 5176 4405 8423 2194
carnitine/ac 2602
ylcarnitine
carrier
protein
3-ketoacyl- Acaa2 ENZ mitocho IPI002264 THIM_M Q3UKH3 ENSMUS 52538 0.84126 0.88 15 3798.27 4538.72 4253.02 6515.29 1788.11 3146.17 1804.87 5839.73 5445.59 2198.38
CoA ndria 30.3 OUSE G0000003 9841 5657 3344 6378 46 0044 6159 6859 9851 0102 6103
thiolase, 6880
mitochondr
ial
28S Mrps36 RIB mitocho IPI003158 RT36_M Q9CQX8 ENSMUS 66128 0.84126 0.93 4 209.332 271.947 252.515 105.463 83.2947 185.554 66.3881 215.191 271.575 119.530
ribosomal ndria 08.3 OUSE G0000006 9841 2833 2324 88 17 9598 0085 9888 7485 7354 1194
protein 1474
S36,
mitochondr
ial
Enoyl-CoA Echs1 ENZ mitocho IPI004540 ECHM_M Q8BH95 ENSMUS 93747 0.84126 0.95 8 1219.75 1388.45 1127.42 1077.16 794.661 1261.89 438.072 1416.27 1374.72 818.126

- 162 -
hydratase, ndria 49.4 OUSE G0000002 9841 9667 4033 4469 7882 4418 7427 8586 6692 3172 6019
mitochondr 5465
ia
3- Hibadh ENZ mitocho IPI009863 3HIDH_ E9Q155 ENSMUS 58875 0.84126 1.08 3 309.105 192.051 160.345 240.157 0 135.915 128.701 365.520 221.229 120.270
hydroxyiso ndria 04.2 MOUSE G0000002 9841 1637 4113 062 6361 7892 7952 1883 3779 9503
butyrate 9776
dehydrogen
ase,
mitochondr
ial
Carnitine Cpt1b ENZ muscle IPI001365 CPT1B_ Q924X2 ENSMUS 12895 0.84126 1.07 15 873.306 1157.37 944.158 817.620 0 900.830 551.977 1045.35 1211.89 330.630
O- 63.4 MOUSE G0000007 9841 6703 5896 4672 078 0723 6995 55 7844 7694
palmitoyltr 8937
ansferase 1,
muscle
isoform
Filamin-C Flnc CS muscle IPI007539 FLNC_M Q8VHX6 ENSMUS 68794 0.84126 1.16 16 843.021 1096.48 1331.26 0 618.555 728.417 632.388 1041.15 1191.95 903.556
17.2 OUSE G0000006 9841 4652 1604 4657 4906 1137 8015 5037 5537 9538
8699
Fibrinogen Fgb MOD secreted IPI002790 FIBB_M Q8K0E8 ENSMUS 110135 0.84126 0.97 11 899.308 1271.90 1084.62 548.878 967.512 1331.95 830.345 1012.81 885.497 589.219
beta chain 79.1 OUSE G0000003 9841 1936 6043 1681 3899 4799 1852 6526 0268 5305 1303
3831
Histone Hist1h1 TF IPI002237 H12_MO P15864 ENSMUS 50708 0.84126 1.10 7 0 1603.09 1756.48 939.516 2848.90 1250.44 685.137 1607.33 1792.26 2494.02
H1.2 c 13.5 USE G0000003 9841 3785 7795 7756 3946 7011 5108 496 6756 9998
6181
Histone Hist1h1 TF IPI002237 H14_MO P43274 ENSMUS 50709 0.84126 0.90 9 1549.97 1464.42 1882.97 1020.05 2803.91 1217.18 654.911 1743.48 1780.28 2471.31
H1.4 e 14.5 USE G0000005 9841 9096 3171 3472 312 5219 4842 6709 873 1981 4161
1627
Anthrax Antxr1 RCP IPI002290 ANTR1_ Q9CZ52 ENSMUS 69538 0.84126 0.90 2 733.248 592.769 317.049 712.738 0 445.064 30.9501 526.844 822.584 300.113
toxin 69.1 MOUSE G0000003 9841 1444 0245 1624 2511 4914 4501 6077 8571 1863
receptor 1 3420
Ferritin Fth1 ENZ IPI002301 FRIH_M P09528 ENSMUS 14319 0.84126 0.81 3 96.4352 40.2367 124.654 0 207.404 67.5414 86.3899 117.703 54.7604 54.7845
heavy chain 45.5 OUSE G0000002 9841 2396 0962 7224 4219 7815 0895 7798 6522 0725
4661
Polycystic Pkd1l2 MOD IPI003180 PK1L2_M Q7TN88 76645 0.84126 1.20 2 307.397 249.910 297.746 0 142.297 259.243 135.814 279.734 348.390 172.719
kidney 10.5 OUSE 9841 8992 1852 3517 5615 0487 1695 8983 319 4446
disease
protein 1-
like 2
Mitogen- Map3k1 ENZ IPI003307 M3K11_ Q80XI6 ENSMUS 26403 0.84126 0.77 2 1827.54 2973.26 6809.24 3449.60 321.880 1759.74 1868.14 3845.93 2408.46 1924.76
activated 1 31.1 MOUSE G0000000 9841 0388 7735 3346 0484 6441 6738 6442 6424 3497 3012
protein 4054
kinase
kinase
kinase 11
Heterogene Hnrnpa TF IPI004050 ROA2_M O88569 ENSMUS 10004519 0.84126 0.98 7 426.446 475.937 295.101 258.116 437.372 234.986 203.345 470.318 588.899 351.858
ous nuclear 2b1 58.6 OUSE G0000000 1 9841 9844 2105 8622 2081 315 3209 2029 5292 4407 7031
ribonucleop 4980
roteins
A2/B1
Protein Gm735 ENZ IPI007560 F6QL59_ F6QL59 ENSMUS 0.84126 1.14 2 0 120.200 150.218 175.398 56.2148 94.0324 62.0373 139.846 180.518 95.9209
Gm7356 6 65.3 MOUSE G0000009 9841 2152 4761 6507 863 3013 2672 7126 9588 7956
1677
Histidine Hint1 ENZ IPI008807 HINT1_M B0R1E3 ENSMUS 15254 0.84126 0.79 1 123.298 119.075 133.093 167.729 127.822 0 78.8690 131.828 187.875 132.782
triad 95.1 OUSE G0000002 9841 9804 9299 0652 2626 9249 6849 6066 5798 4704
nucleotide- 0267

- 163 -
binding
protein 1
Histone H3f3a TF IPI008864 H33_MO F8WI35 ENSMUS 15078 0.84126 0.84 6 4130.49 5017.58 5771.23 5324.53 8542.72 3040.70 1633.75 5420.55 5821.89 8218.87
H3.3 22.1 USE G0000001 9841 623 0969 3376 7218 2409 9177 7318 1898 9383 5507
6559|ENS
MUSG00
00006074
3
Carnitine Crat TP IPI010161 CACP_M H7BX88 ENSMUS 12908 0.84126 0.90 12 403.316 590.333 356.568 396.227 0 297.730 93.0033 444.032 476.680 265.892
O- 08.1 OUSE G0000002 9841 0863 8777 1717 318 3557 9192 9484 0512 5536
acetyltransf 6853
erase
Dermatopo Dpt CS secreted IPI001382 DERM_M Q9QZZ6 ENSMUS 56429 0.90632 0.65 2 0 0 74.6774 0 160.985 55.5334 0 0 0 97.8785
ntin 51.1 OUSE G0000002 9391 3065 0308 0632 3049
6574
von Vwf CS secreted IPI007985 VWF_M Q8CIZ8 ENSMUS 22371 0.90632 0.87 1 1308.30 783.438 0 0 0 0 0 0 1197.65 619.186
Willebrand 76.2 OUSE G0000000 9391 319 9002 3613 4311
factor 1930
Phenyletha Pnmt ENZ IPI001146 PNMT_M P40935 ENSMUS 18948 0.90632 1.27 1 29809.8 0 9610.41 0 0 17493.4 32735.8 0 0 0
nolamine 24.1 OUSE G0000003 9391 4308 0359 6928 4876
N- 8216
methyltrans
ferase
Caveolin-2 Cav2 SCA IPI001258 CAV2_M Q9WVC3 ENSMUS 12390 0.90632 1.25 1 87.6683 108.107 0 0 0 0 0 92.2521 152.295 0
32.1 OUSE G0000000 9391 8695 7649 4986 1801
0058
WSC Wscd1 TM IPI003307 WSCD1_ Q80XH4 ENSMUS 216881 0.90632 0.56 1 407.096 0 0 646.504 0 0 0 0 430.756 157.422
domain- 25.1 MOUSE G0000002 9391 7004 2918 1728 5325
containing 0811
protein 1
Nucleopori Nup188 TP IPI004206 NU188_ Q6ZQH8 ENSMUS 227699 0.90632 0.92 1 109.078 176.745 0 0 0 105.829 0 0 157.397 0
n NUP188 02.3 MOUSE G0000005 9391 8816 9747 2823 3174
homolog 2533
Ig kappa IGG IPI004643 KV5A4_ P01636 0.90632 0.41 2 0 189.043 587.981 0 0 0 0 125.025 192.316 0
chain V-V 80.3 MOUSE 9391 9812 9836 774 2112
region
MOPC 149
ATP- Abca12 TP IPI006243 E9Q876_ Q8CJA1 ENSMUS 74591 0.90632 0.74 5 0 439.464 334.012 0 0 0 0 0 178.886 389.882
binding 57.4 MOUSE G0000005 9391 3737 4939 3926 6883
cassette 0296
sub-family
A member
12
Borealin Cdca8 CC IPI007621 BOREA_ Q8BHX3 ENSMUS 52276 0.90632 0.82 1 82.1471 147.529 0 0 0 71.1687 0 0 116.147 0
39.2 MOUSE G0000002 9391 8249 7485 8856 9884
8873
Retinol Rdh13 ENZ IPI008571 RDH13_ D3YVJ8 ENSMUS 108841 0.90632 2.70 2 0 140.997 77.6956 0 0 460.880 130.041 0 0 0
dehydrogen 45.1 MOUSE G0000000 9391 9227 7098 5483 3889
ase 13 8435
Acetyl- Acat2 ENZ IPI008806 THIC_M F2Z459 ENSMUS 110460 0.91418 0.75 3 179.090 71.7083 0 0 0 42.1485 38.4251 63.6037 44.6764 0
CoA 27.1 OUSE G0000006 355 8845 4496 3949 4872 6134 5756
acetyltransf 2480|ENS
erase, MUSG00
cytosolic 00002383
2
Ryanodine Ryr2 CNL IPI003383 RYR2_M E9Q401 ENSMUS 20191 0.91656 1.03 2 109.729 83.3825 152.438 0 101.454 60.7922 63.7009 114.908 221.965 0

- 164 -
receptor 2 09.5 OUSE G0000002 2645 2735 3167 229 6045 9665 2302 6607 7385
1313
Aldehyde Aldh2 ENZ mitocho IPI001112 ALDH2_ P47738 ENSMUS 11669 1 0.94 11 834.648 747.250 758.883 626.538 449.602 803.032 170.002 901.738 749.001 587.623
dehydrogen ndria 18.1 MOUSE G0000002 2755 5937 6737 506 0052 8539 7202 8692 386 9122
ase, 9455
mitochondr
ial
ATP Atp5i TP mitocho IPI001117 ATP5I_M Q06185 ENSMUS 11958 1 2.15 2 115.285 0 0 0 0 0 0 0 0 248.348
synthase ndria 70.7 OUSE G0000005 5396 6526
subunit e, 0856
mitochondr
ial
Cytochrom Uqcrc1 TP mitocho IPI001118 QCR1_M Q9CZ13 ENSMUS 22273 1 1.00 8 1634.80 1789.09 1677.46 1403.21 735.085 1474.50 736.317 1746.99 2171.30 1122.80
e b-c1 ndria 85.2 OUSE G0000002 4526 7589 886 5518 6353 1306 309 8936 1167 8053
complex 5651
subunit 1,
mitochondr
ial
Enoyl-CoA Eci1 ENZ mitocho IPI001144 ECI1_MO P42125 1 1.03 9 783.505 935.282 994.035 1766.80 344.467 800.168 628.659 1276.79 1649.69 625.401
delta ndria 16.1 USE 2138 468 6891 769 1305 9028 9442 7268 7771 0111
isomerase
1,
mitochondr
ial
Aconitate Aco2 ENZ mitocho IPI001160 ACON_M Q99KI0 ENSMUS 11429 1 0.90 23 12687.6 14882.5 11719.5 14709.7 6304.90 10176.0 5072.66 15758.8 15056.2 8449.45
hydratase, ndria 74.1 OUSE G0000002 1822 5161 0807 3678 4444 3452 1245 0346 1703 8033
mitochondr 2477
ial
NADH- Mtnd4 ENZ mitocho IPI001168 NU4M_M P03911 ENSMUS 17719 1 0.42 1 35.0385 0 0 0 0 0 14.6315 0 0 0
ubiquinone ndria 43.1 OUSE G0000006 1437 0668
oxidoreduct 4363
ase chain 4
Cytochrom Cox4i1 TP mitocho IPI001179 COX41_ P19783 ENSMUS 12857 1 1.02 9 1320.12 1374.40 1228.33 686.003 491.504 855.592 526.160 1176.81 1872.83 779.980
e c oxidase ndria 78.1 MOUSE G0000003 8615 239 8256 665 85 7653 1015 3424 4076 25
subunit 4 1818
isoform 1,
mitochondr
ial
Cytochrom Uqcrc2 TP mitocho IPI001191 QCR2_M Q9DB77 ENSMUS 67003 1 0.98 12 3035.94 2992.88 2710.56 2282.09 1013.27 1744.87 1202.57 3176.17 3995.59 1662.02
e b-c1 ndria 38.1 OUSE G0000003 0739 8268 2442 2 5716 4586 3492 8265 0215 2593
complex 0884
subunit 2,
mitochondr
ial
Very long- Acadvl ENZ mitocho IPI001192 ACADV_ P50544 ENSMUS 11370 1 0.91 23 3872.84 4965.67 4127.71 4145.77 1327.54 2986.74 1500.75 4600.35 5744.87 1884.45
chain ndria 03.4 MOUSE G0000001 9398 9247 4743 321 3914 0315 5852 5171 5271 6112
specific 8574
acyl-CoA
dehydrogen
ase,
mitochondr
ial
10 kDa heat Hspe1 CHA mitocho IPI001200 CH10_M Q9JI95 ENSMUS 15528 1 0.88 4 791.870 996.806 927.235 845.079 578.741 571.039 200.901 945.065 868.062 1049.00
shock ndria 45.1 OUSE G0000007 2537 3023 8429 5394 7016 0618 9921 9796 4218 256
protein, 3676
mitochondr
ial

- 165 -
NADH Ndufa9 TP mitocho IPI001202 NDUA9_ Q9DC69 ENSMUS 66108 1 1.02 9 456.663 724.624 299.299 0 0 402.860 166.102 297.512 519.901 124.312
dehydrogen ndria 12.2 MOUSE G0000000 6161 2353 7317 4698 0343 9329 2402 313
ase 0399
[ubiquinone
] 1 alpha
subcomplex
subunit 9,
mitochondr
ial
Hydroxyac Hadh ENZ mitocho IPI001211 HCDH_M Q61425 ENSMUS 15107 1 0.98 11 1305.21 1896.08 1564.58 2459.17 578.647 1396.84 673.283 2097.14 2712.97 755.009
yl- ndria 05.2 OUSE G0000002 1915 6523 7324 355 5021 7638 8783 4695 3513 5216
coenzyme 7984
A
dehydrogen
ase,
mitochondr
ial
Trans-2- Mecr ENZ mitocho IPI001212 MECR_M Q9DCS3 ENSMUS 26922 1 1.05 5 85.5047 163.931 205.729 0 0 100.109 59.5426 180.498 135.951 0
enoyl-CoA ndria 76.4 OUSE G0000002 4851 6441 8455 7509 8063 0859 4202
reductase, 8910
mitochondr
ial
Cytochrom Cox6a1 ENZ mitocho IPI001214 CX6A1_ P43024 12861 1 0.81 2 79.6667 324.770 146.020 0 38.7105 111.194 44.9298 221.994 100.263 0
e c oxidase ndria 43.1 MOUSE 6092 9374 5085 7718 2228 4706 0144 3904
subunit
6A1,
mitochondr
ial
NADH Ndufs6 TP mitocho IPI001283 NDUS6_ P52503 ENSMUS 407785 1 3.52 3 0 0 30.4389 0 0 107.221 0 0 0 0
dehydrogen ndria 45.2 MOUSE G0000002 328 4907
ase 1606
[ubiquinone
iron-sulfur
protein 6,
mitochondr
ial;
AltName:
Full=Comp
lex I-13kD-
A;
Short=CI-
13kD-A;
AltName:
Full=NAD
H-
ubiquinone
oxidoreduct
ase 13 kDa-
A subunit;
Flags:
Precursor;
NADH Ndufa7 TP mitocho IPI001303 NDUA7_ Q9Z1P6 ENSMUS 66416 1 1.04 3 121.186 167.931 146.745 177.324 0 162.022 30.9186 152.863 190.404 100.945
dehydrogen ndria 22.5 MOUSE G0000004 0272 8911 2635 3282 2975 0721 5677 8264 7643
ase 1881
[ubiquinone
] 1 alpha
subcomplex

- 166 -
subunit 7
Acyl- Acot13 ENZ mitocho IPI001329 ACO13_ Q9CQR4 ENSMUS 66834 1 0.63 2 87.1486 94.6336 401.336 99.9707 0 107.785 50.5588 118.421 98.8177 57.4940
coenzyme ndria 58.1 MOUSE G0000000 8084 5475 852 1529 8181 5972 1707 8499 5366
A 6717
thioesterase
13
Cytochrom Uqcrfs1 ENZ mitocho IPI001332 UCRI_M Q9CR68 ENSMUS 66694 1 0.95 5 0 1053.21 0 971.846 0 704.467 404.686 822.864 0 0
e b-c1 ndria 40.1 OUSE G0000003 5715 4492 7735 936 9334
complex 8462
subunit
Rieske,
mitochondr
ial
Prohibitin Phb TF mitocho IPI001334 PHB_MO O35129 ENSMUS 18673 1 0.97 4 309.207 389.973 54.0623 0 0 108.097 0 199.985 420.334 0
ndria 40.1 USE G0000000 3144 2655 6825 7823 9959 9245
4264|ENS
MUSG00
00003884
5
3- Hibch ENZ mitocho IPI001540 HIBCH_ Q8QZS1 ENSMUS 227095 1 1.17 8 221.369 221.791 105.162 0 0 176.980 82.8034 180.959 201.012 0
hydroxyiso ndria 47.1 MOUSE G0000004 4232 848 2944 0794 1217 6196 749
butyryl- 1426
CoA
hydrolase,
mitochondr
ial
Cytochrom Cycs TP mitocho IPI002224 CYC_MO P62897 ENSMUS 13063 1 1.05 9 2729.24 3004.92 2850.44 2590.72 1268.15 2009.20 1490.60 3458.80 4105.89 2036.63
e c, somatic ndria 19.5 USE G0000005 4987 638 0058 1253 0294 2635 8592 5307 1609 6596
8927|ENS
MUSG00
00006369
4
Pyruvate Pdhx SCA mitocho IPI002227 ODPX_M Q8BKZ9 ENSMUS 27402 1 0.80 8 229.856 462.093 214.316 0 0 265.725 0 243.562 214.442 0
dehydrogen ndria 67.1 OUSE G0000001 9723 0461 4781 8081 432 7678
ase protein 0914
X
component,
mitochondr
ial
ATP Atp5e ENZ mitocho IPI002302 ATP5E_ P56382 ENSMUS 67126 1 7.17 1 25.7222 0 0 0 0 0 0 0 0 184.518
synthase ndria 41.6 MOUSE G0000001 0464 6927
subunit 6252
epsilon,
mitochondr
ial
ADP/ATP Slc25a3 TP mitocho IPI002653 ADT4_M Q3V132 ENSMUS 73333 1 0.79 2 0 0 1838.46 0 0 0 0 0 0 1461.43
translocase 1 ndria 71.3 OUSE G0000006 5711 5999
4 9041
Delta-1- Aldh4a ENZ mitocho IPI004056 AL4A1_ Q8CHT0 ENSMUS 212647 1 1.05 9 144.539 264.726 216.110 69.8933 0 112.236 22.6903 199.803 210.822 183.047
pyrroline-5- 1 ndria 99.3 MOUSE G0000002 108 2899 3275 6056 2278 6026 0502 6479 0447
carboxylate 8737
dehydrogen
ase,
mitochondr
ial
ATP Atp5b TP mitocho IPI004684 ATPB_M P56480 ENSMUS 11947 1 1.17 9 1409.74 1340.81 1689.84 668.744 891.666 1277.63 906.153 998.387 1029.87 2833.38
synthase ndria 81.2 OUSE G0000002 2023 0941 6646 8704 7285 268 8759 5936 4267 0973

- 167 -
subunit 5393
beta,
mitochondr
ial
Isovaleryl- Ivd ENZ mitocho IPI004712 IVD_MO Q9JHI5 ENSMUS 56357 1 1.04 8 471.856 509.673 542.730 553.318 0 391.580 164.942 525.222 555.898 520.836
CoA ndria 46.2 USE G0000002 0097 2004 3964 8458 8958 6311 2497 4394 1429
dehydrogen 7332
ase,
mitochondr
ial
KIF1- Kbp DEV mitocho IPI006482 KBP_MO Q6ZPU9 ENSMUS 72320 1 1.11 1 0 0 112.907 0 0 125.420 0 0 0 0
binding ndria 36.1 USE G0000003 572 3662
protein 6955
NADH Ndufb6 TP mitocho IPI006487 NDUB6_ A2AP32 ENSMUS 230075 1 1.17 1 32.2760 66.1053 29.0812 0 0 26.2560 55.2540 28.6234 38.6953 0
dehydrogen ndria 43.1 MOUSE G0000007 1942 9808 4473 8337 5627 8239 9448
ase 1014
[ubiquinone
] 1 beta
subcomplex
subunit 6
Succinyl- Suclg2 ENZ mitocho IPI006659 SUCB2_ Q9Z2I8 ENSMUS 20917 1 0.92 4 121.594 168.879 145.603 0 0 55.4757 55.9661 151.391 139.619 0
CoA ligase ndria 96.4 MOUSE G0000006 4014 9913 7075 3242 9458 7112 9707
[GDP- 1838
forming]
subunit
beta,
mitochondr
ial
2- Ogdh ENZ mitocho IPI007198 ODO1_M Q60597 ENSMUS 18293 1 0.97 21 2027.55 1797.72 1980.17 1949.38 605.836 1478.78 814.529 2138.88 2886.29 770.919
oxoglutarat ndria 41.1 OUSE G0000002 2087 0862 7616 5784 0848 3094 5809 7753 6323 1109
e 0456
dehydrogen
ase,
mitochondr
ial
Dihydrolip Dlst ENZ mitocho IPI008458 ODO2_M Q9D2G2 ENSMUS 78920 1 1.00 5 909.661 834.366 954.948 740.782 428.696 629.707 345.139 999.192 1387.46 507.357
oyllysine- ndria 58.1 OUSE G0000000 6071 7718 6913 8141 0355 7963 4336 7033 4076 4915
residue 4789
succinyltra
nsferase
component
of 2-
oxoglutarat
e
dehydrogen
ase
complex,
mitochondr
ial
Glyoxalase Glod4 ENZ mitocho IPI009879 GLOD4_ F6ZTG3 ENSMUS 67201 1 0.68 1 0 0 95.1693 0 0 0 0 64.3701 0 0
domain- ndria 28.1 MOUSE G0000001 2677 8719
containing 7286
protein 4
Isocitrate Idh3g ENZ mitocho IPI009888 IDHG1_ Q3TKM5 ENSMUS 15929 1 0.96 5 666.551 719.035 563.439 274.774 71.0076 389.538 236.029 883.542 688.118 0
dehydrogen ndria 42.1 MOUSE G0000000 3481 6652 7197 7992 9724 0699 7775 1116 9853
ase [NAD] 2010
subunit

- 168 -
gamma 1,
mitochondr
ial
Estradiol Hsd17b ENZ mitocho IPI010270 DHB8_M G3UX44 ENSMUS 14979 1 0.91 3 45.0758 0 0 0 0 40.9870 0 0 0 0
17-beta- 8 ndria 72.1 OUSE G0000007 7791 6823
dehydrogen 3422
ase 8
Calponin-3 Cnn3 CS muscle IPI001191 CNN3_M Q9DAW9 ENSMUS 71994 1 0.61 2 0 0 173.485 0 0 0 0 105.818 0 0
11.2 OUSE G0000005 6646 5367
3931
Caldesmon Cald1 CS muscle IPI001224 Q8VCQ8 Q3UGC3 ENSMUS 109624 1 0.28 14 0 0 977.312 0 0 0 0 0 272.053 0
50.1 _MOUSE G0000002 917 5359
9761
Myosin Myl7 TP muscle IPI003951 MLRA_M Q9QVP4 ENSMUS 17898 1 0.53 5 0 0 580.949 0 0 0 0 306.642 0 0
regulatory 46.3 OUSE G0000002 1927 0257
light chain 0469
2, atrial
isoform
Myosin Myl4 TP muscle IPI006484 MYL4_M A2A6Q8 ENSMUS 1 0.70 4 0 0 1009.73 0 0 0 0 705.306 0 0
light chain 31.1 OUSE G0000006 3652 3518
4 1086
Cardiomyo Cmya5 UK muscle IPI009570 CMYA5_ E9QLJ0 ENSMUS 1 0.57 3 211.609 0 0 0 0 0 120.261 0 0 0
pathy- 44.1 MOUSE G0000004 9961 3982
associated 7419
protein 5
Chymotryp Cela2a ENZ secreted IPI001173 CEL2A_ Q91X79 ENSMUS 13706 1 0.15 2 0 0 0 936.131 0 0 0 0 0 137.236
sin-like 15.1 MOUSE G0000002 9869 3824
elastase 3031|ENS
family MUSG00
member 2A 00005857
9
Kininogen- Kng1 INH secreted IPI001292 KNG1_M O08677 ENSMUS 16644 1 0.94 4 0 0 0 0 184.834 174.288 0 0 0 0
1 25.1 OUSE G0000002 9322 0109
2875
Tenascin-X Tnxb CS secreted IPI001307 O54796_ Q3TAQ2 1 0.99 4 210.488 0 0 0 0 0 0 207.693 0 0
94.1 MOUSE 3211 148
Serine Serpina INH secreted IPI001356 SPA3M_ Q03734 ENSMUS 20717 1 0.35 3 0 0 628.559 0 0 0 217.025 0 0 0
protease 3m 35.2 MOUSE G0000007 4787 3181
inhibitor 9012
A3M
Perforin-1 Prf1 SIG secreted IPI003089 PERF_M P10820 ENSMUS 18646 1 1.01 1 0 57.7629 0 0 0 58.3364 0 0 0 0
93.3 OUSE G0000003 6645 6312
7202
Plasminoge Plg ENZ secreted IPI003229 PLMN_M P20918 ENSMUS 18815 1 0.69 7 0 0 47.0174 0 260.463 0 106.335 0 0 105.192
n 36.2 OUSE G0000005 4296 0916 2324 2704
9481
Cystatin- Cstl1 INH secreted IPI004658 Q64FK5_ Q64FK5 1 0.44 1 0 0 0 0 102.819 44.7529 0 0 0 0
like 1 74.1 MOUSE 6438 4572
Brevican Bcan DEV secreted IPI006233 PGCB_M Q61361 ENSMUS 12032 1 0.56 2 499.653 0 0 0 0 279.312 0 0 0 0
core protein 71.3 OUSE G0000000 7397 4381
4892
Apolipopro Apob SIG secreted IPI009747 E9Q1Y3_ E9Q1Y3 ENSMUS 1 0.69 1 0 0 151.080 0 0 104.129 0 0 0 0
tein B-100 06.1 MOUSE G0000002 3073 6384
0609
Protein Fam162 TM IPI001096 F162A_M Q9D6U8 ENSMUS 70186 1 0.94 2 0 0 47.9451 0 0 44.8378 0 0 0 0
FAM162A a 11.1 OUSE G0000000 9318 3462

- 169 -
 3955
Alpha- Alpk1 ENZ IPI001101 ALPK1_ Q9CXB8 ENSMUS 1 0.79 1 0 177.440 0 0 0 140.197 0 0 0 0
protein 30.2 MOUSE G0000002 4839 1306
kinase 1 8028
Actin, Acta1 CS IPI001108 ACTS_M Q61264 ENSMUS 11459 1 1.40 20 18893.4 22145.6 0 22056.1 21491.4 20436.8 13503.1 21891.2 19449.1 42904.2
alpha 27.1 OUSE G0000003 1705 1438 4922 0044 4336 8715 9986 3894 8621
skeletal 1972
muscle
Transcripti Mzf1 TF IPI001156 Q8K4N4_ Q6P9Q8 1 0.83 1 0 0 316.249 265.441 158.387 175.504 86.4333 354.070 0 0
on factor 87.1 MOUSE 6198 8786 3959 3362 215 401
MZF-2A
(Myeloid
zinc finger
1)
Liver Ces1 ENZ IPI001158 EST1_M P61406 ENSMUS 12623 1 0.49 2 395.810 0 0 0 0 0 194.480 0 0 0
carboxylest 67.4 OUSE G0000003 0395 1981
erase 1 8290|ENS
MUSG00
00005707
4
40S Rps25 RIB IPI001159 RS25_M D3YXG3 ENSMUS 75617 1 0.69 3 0 0 0 273.119 0 0 0 187.262 0 0
ribosomal 92.1 OUSE G0000006 9322 9004
protein S25 3739|ENS
MUSG00
00000992
7
Polycystin- Pkd1 MOD IPI001163 PKD1_M O08852 ENSMUS 18763 1 0.83 4 371.591 0 249.392 246.311 0 338.754 303.598 0 28.2705 45.0799
1 77.6 OUSE G0000003 8292 0007 714 2026 6964 9361 7665
2855
Actin, Acta2 CS IPI001170 ACTA_M Q3U122 ENSMUS 11475 1 1.27 21 18874.1 22277.4 27913.1 0 21583.7 19804.2 13320.5 21881.0 19469.4 40957.3
aortic 43.1 OUSE G0000003 6001 1835 8202 2784 1825 654 224 6262 2492
smooth 5783
muscle
Phosphatid Pik3r2 SCA IPI001171 P85B_M O08908 ENSMUS 18709 1 0.92 2 0 0 42.6196 1128.72 0 0 319.637 0 755.073 0
ylinositol 59.2 OUSE G0000003 7215 7341 8258 185
3-kinase 1834
regulatory
subunit
beta
Nicastrin Ncstn SIG IPI001186 NICA_M P57716 ENSMUS 59287 1 0.68 3 0 0 0 0 103.499 0 0 70.2754 0 0
74.8 OUSE G0000000 2681 7663
3458
Farnesyl Fdps ENZ IPI001204 FPPS_M Q920E5 ENSMUS 110196 1 0.44 1 0 0 123.825 0 0 0 0 54.4412 0 0
pyrophosph 57.1 OUSE G0000005 0584 6115
ate synthase 9743
Protein Ppp1r3f MOD IPI001205 PPR3F_M Q9JIG4 ENSMUS 54646 1 1.86 2 0 0 0 265.441 0 0 0 0 494.457 0
phosphatas 35.6 OUSE G0000003 8786 3975
e1 9556
regulatory
subunit 3F
Protein Wwc2 UK IPI001211 WWC2_ Q6NXJ0 ENSMUS 52357 1 1.03 3 31689.6 20602.6 16212.7 24443.7 12652.1 16900.8 30695.1 22120.9 26754.8 12284.6
WWC2 00.4 MOUSE G0000003 6301 2625 1999 6713 0794 7925 3506 5321 3337 261
1563
Serpin B6 Serpinb INH IPI001214 SPB6_M Q60854 ENSMUS 20719 1 1.36 3 0 129.911 0 0 0 0 0 176.259 0 0
6 71.1 OUSE G0000006 406 6295
0147

- 170 -
Carbonic Ca2 ENZ IPI001215 CAH2_M P00920 ENSMUS 12349 1 1.17 8 2433.69 1688.88 1141.18 1876.37 781.226 1458.54 3373.68 1600.75 2131.26 726.408
anhydrase 2 34.11 OUSE G0000002 4762 9816 3515 926 0418 7586 6483 1245 4668 0973
7562
Nuclear Nr4a1 TF IPI001217 NR4A1_ P12813 ENSMUS 15370 1 1.90 2 0 0 179.793 0 0 0 0 0 0 342.452
receptor 33.1 MOUSE G0000002 6141 7684
subfamily 4 3034
group A
member 1
Chymosin Cym ENZ IPI001219 B7ZWD6 B7ZWD6 ENSMUS 229697 1 0.55 1 126.575 0 0 0 0 70.0491 0 0 0 0
47.4 _MOUSE G0000004 1905 0947
6213
O-acetyl- Macrod ENZ IPI001227 MACD1_ Q922B1 ENSMUS 107227 1 0.38 2 113.148 0 0 0 0 0 42.9893 0 0 0
ADP-ribose 1 40.2 MOUSE G0000003 3847 676
deacetylase 6278
MACROD
1
Coiled-coil Ccdc14 UK IPI001230 E9Q9F7_ Q5DTX2 ENSMUS 75172 1 1.45 2 0 0 0 119.524 0 0 0 0 0 173.366
domain- 6 87.6 MOUSE G0000006 394 1568
containing 4280
protein 146
Abhydrolas Abhd14 DEV IPI001232 ABHEA_ Q922Q6 1 1.36 1 0 94.9645 0 0 0 0 0 128.859 0 0
e domain- a 80.5 MOUSE 7301 137
containing
protein 14A
Vigilin Hdlbp TP IPI001233 VIGLN_ Q8VDJ3 ENSMUS 110611 1 0.39 2 95.6781 0 0 0 0 37.5501 0 0 0 0
79.1 MOUSE G0000003 0529 7691
4088
Cullin-1 Cul1 MOD IPI001240 CUL1_M Q9WTX6 ENSMUS 26965 1 0.82 2 0 0 298.098 0 0 245.246 0 0 0 0
47.1 OUSE G0000002 6474 443
9686
Golgin Golga7 TP IPI001273 GOGA7_ Q91W53 ENSMUS 57437 1 0.48 1 0 0 81.2086 0 0 0 0 39.1569 0 0
subfamily 15.1 MOUSE G0000001 8665 2351
A member 5341
7
MCG15085 Try4 ENZ IPI001281 Q9R0T7_ Q9R0T7 ENSMUS 22074 1 0.67 2 0 0 0 417.949 0 0 0 0 0 280.745
Try4 08.1 MOUSE G0000005 3219 5599
trypsinogen 4106
5'-AMP- Prkag2 ENZ IPI001281 AAKG2_ Q91WG5 ENSMUS 108099 1 1.31 1 208.768 50.0392 80.9541 51.5059 0 60.7276 359.040 91.5758 0 0
activated 26.2 MOUSE G0000002 2634 9336 6375 2097 4509 3667 9083
protein 8944
kinase
subunit
gamma-2
Oligosacch Ostc TM IPI001322 OSTC_M Q78XF5 ENSMUS 66357 1 0.83 1 0 0 47.7413 0 0 0 39.3986 0 0 0
aryltransfer 18.3 OUSE G0000004 6015 2771
ase 1084
complex
subunit
OSTC
Voltage- Cacnb3 CNL IPI001335 CACB3_ P54285 1 1.39 2 0 356.904 0 0 0 0 0 0 0 496.583
dependent 18.2 MOUSE 6771 8855
L-type
calcium
channel
subunit
beta-3

- 171 -
Ras-related Rab1b TP IPI001337 RAB1B_ Q9D1G1 ENSMUS 76308 1 1.12 6 240.769 0 234.637 0 0 0 83.2840 0 219.350 230.386
protein 06.1 MOUSE G0000002 4157 6782 8299 1381 1823
Rab-1B 4870
Leucine- Lingo1 SIG IPI001342 LIGO1_M Q9D1T0 ENSMUS 235402 1 0.78 1 0 13.6811 0 0 0 10.7120 0 0 0 0
rich repeat 00.1 OUSE G0000004 2196 7173
and 9556
immunoglo
bulin-like
domain-
containing
nogo
receptor-
interacting
protein 1
Creatine Ckb ENZ IPI001367 KCRB_M Q04447 ENSMUS 12709 1 0.92 3 0 0 118.422 0 125.909 0 0 133.909 91.4208 0
kinase B- 03.1 OUSE G0000000 419 2455 0521 4507
type 1270
Adenylyl Cap1 CS IPI001373 CAP1_M P40124 ENSMUS 12331 1 0.75 4 0 0 0 0 130.705 97.4111 0 0 0 0
cyclase- 31.7 OUSE G0000002 2798 6199
associated 8656
protein 1
Protein 493058 UK IPI001375 Q9D4P3_ Q9D4P3 ENSMUS 1 0.80 2 0 409.532 0 0 0 0 0 0 326.742 0
4930584F2 4F24Ri 18.1 MOUSE G0000002 4926 4331
4Rik k 9044
Phosphoeth Phosph ENZ IPI001535 PHOP1_ Q8R2H9 ENSMUS 237928 1 1.82 1 36.4574 0 0 0 0 66.2849 0 0 0 0
anolamine/ o1 82.1 MOUSE G0000005 3739 8054
phosphocho 0860
line
phosphatas
e
Serpin B10 Serpinb INH IPI001697 SPB10_M Q8K1K6 1 0.61 1 89.2499 0 0 0 0 0 0 54.4412 0 0
10 78.1 OUSE 0918 6115
Nucleoside Nudt18 ENZ IPI001698 NUD18_ Q3U2V3 ENSMUS 213484 1 1.37 2 133.917 124.262 0 0 0 0 103.693 122.898 126.921 0
diphosphate 60.2 MOUSE G0000004 3452 031 938 3737 8496
-linked 5211
moiety X
motif 18
Protein Sdk2 CS IPI001729 SDK2_M Q6V4S5 ENSMUS 237979 1 1.26 2 40.9348 31.8507 47.4577 0 0 82.5982 22.5528 0 46.7406 0
sidekick-2 06.2 OUSE G0000004 7847 5627 8092 196 1112 4185
1592
60S Rpl22 RIB IPI002225 RL22_M Q4VAG4 ENSMUS 10050486 1 0.70 2 134.457 189.576 64.9982 0 0 42.2881 0 67.3175 72.4236 92.2243
ribosomal 46.5 OUSE G0000002 3 1275 7107 5568 5649 926 9181 5278
protein L22 8936
FH1/FH2 Fhod1 CS IPI002230 FHOD1_ Q6P9Q4 ENSMUS 234686 1 1.60 1 0 0 0 0 35.9398 57.3589 0 0 0 0
domain- 46.6 MOUSE G0000001 4181 2685
containing 4778
protein 1
Poly [ADP- Parp12 ENZ IPI002272 PAR12_ Q8BZ20 ENSMUS 243771 1 0.23 2 0 0 257.317 0 0 0 0 59.4739 0 0
ribose] 51.5 MOUSE G0000003 9873 2925
polymerase 8507
12
Signal Spcs2 ENZ IPI002282 SPCS2_M Q6P6M7 ENSMUS 66624 1 0.48 1 0 0 0 0 104.003 50.0262 0 0 0 0
peptidase 36.6 OUSE G0000002 5076 3669
complex 9173|ENS
subunit 2 MUSG00
00003522

- 172 -
 7
Histone Hist1h1 TF IPI002286 H11_MO P43275 ENSMUS 80838 1 0.68 3 0 0 0 0 1245.31 0 0 0 0 845.304
H1.1 a 16.5 USE G0000004 9486 9886
9539
Cysteinyl Cysltr1 RCP IPI002295 CLTR1_ Q99JA4 ENSMUS 58861 1 0.56 1 0 0 205.176 0 0 115.812 0 0 0 0
leukotriene 94.1 MOUSE G0000005 468 7215
receptor 1 2821
Glycogen Pygb ENZ IPI002297 PYGB_M Q8CI94 ENSMUS 110078 1 1.30 4 110.469 0 0 0 0 0 0 143.991 0 0
phosphoryl 96.3 OUSE G0000003 8522 0108
ase, brain 3059
form
ATP- Abcc9 CNL IPI002306 ABCC9_ P70170 ENSMUS 20928 1 0.68 1 0 0 984.471 0 0 670.662 0 0 0 0
binding 88.1 MOUSE G0000003 9157 2512
cassette 0249
sub-family
C member
9
CD2- Cd2ap CS IPI002686 CD2AP_ Q9JLQ0 ENSMUS 12488 1 0.16 2 264.311 0 0 0 0 0 43.3137 0 0 0
associated 88.4 MOUSE G0000006 186 7959
protein 1665
Spectrin Spnb4 CS IPI002701 Q8VIE5_ E9PZC2 ENSMUS 80297 1 6.56 3 0 0 58.1730 0 0 381.872 0 0 0 0
beta chain, 49.6 MOUSE G0000001 5933 6361
brain 3 1751
Putative Rbm15 TF IPI002789 RB15B_ Q6PHZ5 ENSMUS 109095 1 0.44 1 0 0 0 0 272.496 120.204 0 0 0 0
RNA- b 42.5 MOUSE G0000004 0551 3074
binding 5365
protein 15B
Dynein Dnahc7 CS IPI002837 E9Q0C8_ E9Q0C8 ENSMUS 227058 1 0.76 7 171.210 0 178.789 0 0 194.104 70.6556 0 0 0
heavy chain b 55.6 MOUSE G0000004 6117 1135 8306 7522
7, 1144
axonemal
Sodium/pot Atp1a1 TP IPI003116 AT1A1_ Q8VDN2 ENSMUS 11928 1 1.09 7 0 0 0 0 283.297 0 0 0 0 309.248
assium- 82.5 MOUSE G0000003 1959 1328
transporting 3161
ATPase
subunit
alpha-1
Synapse- Syap1 UK IPI003175 SYAP1_ Q9D5V6 ENSMUS 67043 1 0.95 2 397.387 399.938 180.991 0 0 189.398 0 180.788 557.330 0
associated 99.3 MOUSE G0000003 1801 2459 3995 686 8406 3821
protein 1 1357
Keratin, Krt8 CS IPI003222 K2C8_M P11679 ENSMUS 16691 1 0.40 8 0 0 0 1092.17 0 0 0 442.062 0 0
type II 09.5 OUSE G0000004 6164 4337
cytoskeletal 9382
8
Rho GDP- Arhgdia MOD IPI003223 GDIR1_ Q99PT1 ENSMUS 192662 1 1.12 3 0 111.711 135.128 0 150.526 43.0008 0 106.125 117.847 178.019
dissociation 12.3 MOUSE G0000002 3689 2411 326 5587 3496 4968 5913
inhibitor 1 5132
Coiled-coil Ccdc22 UK IPI003312 CCD22_ Q9JIG7 ENSMUS 54638 1 0.74 1 39.2242 0 0 0 0 0 28.8918 0 0 0
domain- 44.4 MOUSE G0000003 8064 0481
containing 1143
protein 22
Myb- Mybbp1 TF IPI003313 MBB1A_ Q7TPV4 ENSMUS 18432 1 2.93 3 214.314 0 0 0 0 627.402 0 0 0 0
binding a 61.2 MOUSE G0000004 5539 7551
protein 1A 0463
Proteasome Psma3 ENZ IPI003316 PSA3_M O70435 ENSMUS 19167 1 0.37 2 104.193 0 0 0 0 0 38.5428 0 0 0
subunit 44.5 OUSE G0000006 79 5648

- 173 -
alpha type- 0073
3
Calreticulin Calr4 CHA IPI003437 Q3TQS0_ A2A8Z3 ENSMUS 108802 1 0.91 1 0 0 369.286 0 0 0 0 0 334.701 0
4 34.2 MOUSE G0000002 7915 2601
8558
Selection Skint6 TM IPI003473 SKIT6_M A7XUZ6 ENSMUS 230622 1 0.62 2 0 0 98.6556 319.339 0 105.829 0 74.8010 0 77.2547
and upkeep 78.9 OUSE G0000008 2796 3919 2823 6801 3219
of 7194
intraepitheli
al T-cells
protein 6
Potassium Kcna10 CNL IPI003567 B2RXZ4_ B2RXZ4 ENSG000 1 2.30 1 43.3983 0 0 0 0 0 0 99.9018 0 0
voltage- 91.3 MOUSE 00143105 085 3288
gated
channel
subfamily
A member
10
WAS/WAS Wipf2 CS IPI003787 WIPF2_M Q6PEV3 ENSMUS 68524 1 1.38 3 1098.93 0 0 0 0 0 1519.54 0 0 0
L- 28.1 OUSE G0000003 9556 7094
interacting 8013
protein
family
member 2
WD repeat- Wdr7 UK IPI003809 WDR7_M Q920I9 ENSMUS 104082 1 1.07 1 0 0 0 76.7710 0 0 0 0 82.0393 0
containing 97.4 OUSE G0000004 831 7245
protein 7 0560
Putative Gm163 UK IPI003810 Q3UL49_ Q3UL49 ENSMUS 545762 1 1.55 1 227.350 0 0 0 0 0 0 0 352.897 0
uncharacter 67 64.4 MOUSE G0000007 1885 896
ized protein 9214
Gm16367
Nuclear Nrip1 TF IPI003874 NRIP1_M Q8CBD1 ENSMUS 268903 1 0.28 1 0 0 0 0 527.846 148.252 0 0 0 0
receptor- 20.1 OUSE G0000004 3613 2672
interacting 8490
protein 1
Serine/thre Smg1 ENZ IPI004033 SMG1_M Q8BKX6 ENSMUS 233789 1 0.64 3 645.083 0 0 0 0 0 0 0 0 412.544
onine- 52.7 OUSE G0000003 8661 405
protein 0655
kinase
SMG1
TAF6-like Taf6l TF IPI004053 TAF6L_ Q8R2K4 ENSMUS 225895 1 0.46 1 212.396 0 0 0 0 0 0 0 98.1207 0
RNA 76.2 MOUSE G0000000 9253 2024
polymerase 3680
II
p300/CBP-
associated
factor-
associated
factor 65
kDa
subunit 6L
Sodium/pot Slc24a2 TP IPI004062 Q14BI1_ Q8BYP4 ENSMUS 76376 1 0.82 1 0 0 99.2952 0 0 0 81.1450 0 0 0
assium/calc 00.1 MOUSE G0000003 5481 1548
ium 7996
exchanger 2
Keratin, Krt7 CS IPI004063 K2C7_M Q6IFZ9 ENSMUS 110310 1 1.05 4 0 572.456 0 0 0 0 0 0 598.911 0
type II 77.3 OUSE G0000006 4733 2492

- 174 -
cytoskeletal 7596|ENS
7 MUSG00
00002303
9
Ras-related Rab7a TP IPI004088 RAB7A_ P51150 ENSMUS 19349 1 1.43 2 0 0 0 0 75.1177 107.137 0 0 0 0
protein 92.2 MOUSE G0000007 215 1553
Rab-7a 9477
Keratin, Krt74 CS IPI004209 K2C74_M Q9DCV7 ENSMUS 1 1.20 1 0 146.534 101.817 0 0 101.123 0 0 196.394 0
type II 70.3 OUSE G0000002 6283 1199 6349 8099
cytoskeletal 3039|ENS
74 MUSG00
00006759
6
Potassium Kcnv1 CNL IPI004576 KCNV1_ Q8BZN2 ENSMUS 67498 1 1.15 1 148.903 57.2976 123.825 78.1156 124.288 137.384 71.9364 115.279 74.0478 216.121
voltage- 60.2 MOUSE G0000002 8696 8422 0584 2816 1494 6756 7235 9572 9014 7691
gated 2342
channel
subfamily
V member
1
BRCA1-A Uimc1 TF IPI004592 UIMC1_ Q8C5J8 ENSMUS 20184 1 0.11 1 0 0 0 0 918.450 96.5409 0 0 0 0
complex 84.1 MOUSE G0000002 2969 3379
subunit 5878
RAP80
ATP- Ddx18 ENZ IPI004593 DDX18_ Q8K363 ENSMUS 66942 1 0.48 1 0 121.896 0 0 0 0 58.7653 0 0 0
dependent 81.2 MOUSE G0000000 8891 954
RNA 1674
helicase
DDX18
Pleckstrin Plekha5 UK IPI004606 E9Q3A1_ E9Q3A1 ENSMUS 1 3.01 2 0 0 42.9795 0 0 0 0 129.164 0 0
homology 78.3 MOUSE G0000003 8851 4299
domain- 0231
containing
family A
member 5
Uncharacte UK IPI004618 CI131_M Q3V0E1 ENSMUS 67317 1 0.56 2 76.5022 0 0 0 0 0 42.5447 0 0 0
rized 34.2 OUSE G0000002 8059 0521
protein 8451
C9orf131
homolog
Zinc finger Zfp335 TF IPI004618 Q3TZT1_ Q8C1Q2 1 0.34 2 386.953 0 0 0 0 0 0 0 131.345 0
protein 335 51.4 MOUSE 1035 1816
Ig kappa IGG IPI004628 KV5A6_ P01638 1 0.54 3 0 0 0 0 250.691 0 134.324 0 0 0
chain V-V 09.1 MOUSE 4397 5491
region L6
Talin-1 Tln1 CS IPI004657 TLN1_M P26039 ENSMUS 21894 1 0.98 31 1342.29 705.575 1346.20 0 577.298 891.559 359.088 1120.18 588.870 923.406
86.4 OUSE G0000002 9086 2233 1637 0828 2477 1734 3848 4589 1826
8465
Protein Cyp3a2 TP IPI004657 CP3AP_ D3Z2W7 ENSMUS 56388 1 0.59 2 121.332 0 0 0 0 0 0 0 71.0884 0
Cyp3a59 5 98.5 MOUSE G0000006 5386 1479
(Cytochrom 1292|ENS
e P450 MUSG00
3A25) 00002963
0
Sarcoplasm Atp2a2 TP IPI004689 AT2A2_ O55143 11938 1 0.73 6 0 0 283.668 0 0 0 0 207.644 0 0
ic/endoplas 00.5 MOUSE 2598 6418

- 175 -
mic
reticulum
calcium
ATPase 2
Thymocyte Tox DEV IPI004714 TOX_MO Q66JW3 ENSMUS 252838 1 0.99 1 232.663 198.914 86.6300 0 0 0 276.758 235.491 0 0
selection- 52.5 USE G0000004 0405 7213 2361 6068 8775
associated 1272
high
mobility
group box
protein
TOX
Putative Zfp507 TF IPI004749 Q8CAI7_ Q8CAI7 1 0.76 1 597.760 0 0 0 0 456.059 0 0 0 0
uncharacter 55.1 MOUSE 3116 304
ized protein
Zfp507
Igh protein Ighg1 IGG IPI004752 Q99LC4_ Q99LC4 1 1.00 3 240.679 0 0 0 0 0 0 0 239.995 0
46.1 MOUSE 9453 233
Polycystic Pkd1l1 CS IPI005157 Q5SVC7_ Q5SVC7 1 0.75 3 3456.07 1341.28 800.542 896.963 1871.18 1364.48 1142.95 1352.43 1582.31 870.204
kidney 13.7 MOUSE 5532 446 809 6846 7276 1035 3986 2228 0533 2421
disease
protein 1-
like 1
Tankyrase- Tnks2 ENZ IPI005533 TNKS2_ Q3UES3 ENSMUS 74493 1 3.39 2 0 94.1708 0 0 0 0 0 0 319.363 0
2 66.4 MOUSE G0000002 1332 5106
4811
Neuroblast Ahnak DEV IPI005537 Q8CGE7_ Q8CGE7 1 0.91 40 2921.41 2620.79 4356.50 2040.39 2003.32 2116.67 1258.88 3040.32 2919.46 3372.32
differentiati 98.2 MOUSE 9503 4509 1574 3454 0434 3376 6383 1018 7888 6782
on-
associated
protein
AHNAK
Neuronal- Sept3 CS IPI005548 SEPT3_M Q5DTK0 ENSMUS 24050 1 0.09 1 446.999 0 0 0 0 0 40.4444 0 0 0
specific 48.1 OUSE G0000002 7035 6369
septin-3 2456
Tyrosine- Blk ENZ IPI005550 BLK_MO Q3TAT8 ENSMUS 12143 1 1.00 1 82.1471 147.529 100.458 0 0 71.1687 0 109.099 62.5256 88.4837
protein 03.3 USE G0000001 8249 7485 4817 8856 474 8064 6025
kinase Blk 4453
Anti-human Gm974 IGG IPI005568 Q811U5_ Q811U5 1 0.35 1 0 0 79.1172 0 0 0 0 27.4473 0 0
Fc gamma 0 16.1 MOUSE 2314 7512
receptor III
3G8
gamma
heavy chain
variable
region
Igh protein Gm168 IGG IPI005568 Q58E61_ Q58E61 1 0.56 3 0 0 0 0 120.535 0 67.6972 0 0 0
44 70.1 MOUSE 2255 1324
Teneurin-1 Odz1 SIG IPI006058 TEN1_M A2ANL9 ENSMUS 23963 1 0.37 1 328.947 0 0 0 0 0 123.305 0 0 0
12.3 OUSE G0000001 8876 8878
6150
Myosin-14 Myh14 CS IPI006080 MYH14_ Q6URW6 ENSMUS 71960 1 1.03 8 0 0 0 0 749.273 0 0 0 773.643 0
77.3 MOUSE G0000003 9142 4057
0739
Beta- Ctnnbl1 SIG IPI006227 CTBL1_ Q9CWL8 ENSMUS 66642 1 3.96 2 96.5671 0 0 0 0 0 0 0 0 382.494
catenin-like 16.4 MOUSE G0000002 3065 546

- 176 -
protein 1 7649
Ryanodine Ryr1 CNL IPI006229 RYR1_M E9PZQ0 ENSMUS 20190 1 0.94 10 1115.37 29.9994 881.971 27.4352 2591.53 1224.81 32.0622 27.0751 1052.51 2042.07
receptor 1 12.3 OUSE G0000003 3229 2023 3598 8908 0109 4803 9301 1058 3273 1438
0592
Protein Unc13b TP IPI006247 UN13B_ E9Q845 ENSMUS 22249 1 0.74 2 1351.21 0 0 0 0 0 0 1000.23 0 0
unc-13 73.4 MOUSE G0000002 3999 995
homolog B 8456
Eukaryotic Eif5a TF IPI006487 IF5A1_M Q5NCX0 ENSMUS 276770 1 0.57 2 0 0 0 0 149.689 85.1582 0 0 0 0
translation 14.1 OUSE G0000007 8165 595
initiation 8812
factor 5A-1
Uncharacte UK IPI006494 CA141_M Q9D5Q8 ENSMUS 70941 1 1.49 2 0 513.410 0 0 0 766.606 0 0 0 0
rized 98.2 OUSE G0000002 5794 7771
protein 8520
C1orf141
homolog
mRNA- Rngtt TF IPI006496 MCE1_M Q3TUK6 ENSMUS 24018 1 2.74 2 0 748.236 0 0 0 2052.25 0 0 0 0
capping 40.1 OUSE G0000002 694 3266
enzyme 8274
Protein C13004 UK IPI006519 Q3US44_ Q3US44 ENSMUS 1 0.24 2 0 0 0 0 1433.45 0 0 0 0 342.123
C130040N 0N14Ri 21.1 MOUSE G0000007 2537 0428
14Rik k 3429
Syntaxin- Stxbp3 TP IPI006521 STXB3_ Q60770 ENSMUS 20912 1 1.51 2 0 937.880 0 0 0 0 0 0 0 1420.65
binding 34.2 MOUSE G0000002 887 9692
protein 3 7882
Protein Gm793 UK IPI006522 Q3UTG5_ Q3UTG5 ENSMUS 1 1.49 1 0 177.671 0 0 0 0 0 0 265.538 0
Gm7932 2 34.1 MOUSE G0000007 4883 2583
3090
Telomeric Terf1 CC IPI006527 TERF1_ Q3V252 ENSMUS 21749 1 0.82 2 84.5912 69.8564 0 0 0 27.8675 0 0 98.9484 0
repeat- 60.1 MOUSE G0000002 8522 0608 0069 4108
binding 5925
factor 1
Vacuolar Vta1 TP IPI006529 VTA1_M Q3V4B3 ENSMUS 66201 1 1.41 2 0 0 0 69.2119 0 0 0 97.2703 0 0
protein 76.2 OUSE G0000001 332 2558
sorting- 9868
associated
protein
VTA1
homolog
Putative ENSM UK IPI006530 Q3USU0_ Q3USU0 1 0.42 1 0 0 58.6354 0 0 24.7090 0 0 0 0
uncharacter USG00 26.1 MOUSE 7927 7074
ized protein 000075
ENSMUSG 293
000000752
93
THAP Thap7 TF IPI006533 THAP7_ Q3V481 ENSMUS 69009 1 0.23 2 0 0 344.091 0 0 0 0 0 80.0281 0
domain- 82.1 MOUSE G0000002 3415 3483
containing 2760
protein 7
TBC1 Tbc1d2 MOD IPI006537 TB22A_ E9QMS2 ENSMUS 223754 1 0.18 2 0 0 0 1334.50 0 241.747 0 0 0 0
domain 2a 91.3 MOUSE G0000005 4598 9799
family 1864
member
22A
Uncharacte Kiaa198 UK IPI006653 K1984_M A2AJB1 ENSMUS 77058 1 1.06 2 0 114.372 208.313 114.583 0 78.9178 0 184.685 200.641 0
rized 4 75.2 OUSE G0000002 4436 9788 105 473 5654 9484

- 177 -
coiled-coil 6940
domain-
containing
protein
KIAA1984
ATPase Atad2b UK IPI006668 E9Q166_ Q571M9 ENSMUS 320817 1 0.18 1 185.104 0 0 0 0 0 0 0 32.4459 0
family 89.3 MOUSE G0000005 0275 7388
AAA 2812
domain-
containing
protein 2B
Malignant Mfhas1 UK IPI006698 MFHA1_ Q3V1N1 ENSMUS 52065 1 0.82 2 0 0 0 43.8685 0 35.8915 0 0 0 0
fibrous 35.1 MOUSE G0000007 7472 5834
histiocytom 0056
a-amplified
sequence 1
homolog
M-phase Mphosp CS IPI006731 MPP9_M A6H5Y1 1 1.16 2 0 0 0 48.5104 0 0 0 0 56.2303 0
phosphopro h9 26.2 OUSE 8373 1577
tein 9
Ras-related Rab8b TP IPI007513 RAB8B_ E9Q445 ENSMUS 235442 1 0.43 3 0 0 0 295.638 0 126.521 0 0 0 0
protein 03.2 MOUSE G0000003 0397 1441
Rab-8B 6943
Dedicator Dock5 MOD IPI007615 DOCK5_ B2RY04 ENSMUS 68813 1 3.10 3 0 0 0 0 34.6562 0 107.335 0 0 0
of 36.6 MOUSE G0000004 9628 0672
cytokinesis 4447
protein 5
Lipolysis- Lsr RCP IPI007615 LSR_MO Q99KG5 ENSMUS 54135 1 0.93 1 446.999 0 388.315 0 0 0 163.979 0 612.921 0
stimulated 68.1 USE G0000000 7035 4055 3014 4862
lipoprotein 1247
receptor
BRCA1- Brat1 SIG IPI007624 BRAT1_ D6RE40 ENSMUS 231841 1 0.29 1 0 0 391.451 0 0 0 0 114.364 0 0
associated 41.2 MOUSE G0000000 9951 214
ATM 0148
activator 1
Spermatid- Smrp1 DEV IPI007883 SMRP1_ Q2MH31 ENSMUS 73721 1 1.79 1 66.0045 0 0 0 0 118.088 0 0 0 0
specific 25.1 MOUSE G0000002 349 6254
manchette- 8441
related
protein 1
Heterogene Hnrnpf TF IPI007985 HNRPF_ Q9Z2X1 ENSMUS 98758 1 0.62 2 0 0 0 0 61.0728 0 0 0 38.0936 0
ous nuclear 11.1 MOUSE G0000004 9969 5337
ribonucleop 2079
rotein F
Ankyrin Ankrd1 SCA IPI008285 E9PXS7_ Q6PB57 ENSMUS 1 0.77 2 0 651.510 0 0 0 0 0 0 0 498.903
repeat 1 84.4 MOUSE G0000003 6166 9915
domain- 5569
containing
protein 11
Ig gamma-1 Ighg1 IGG IPI008302 IGHG1_ P01868 1 0.40 2 0 284.877 0 0 0 0 0 0 0 112.773
chain C 15.1 MOUSE 4785 99
region
secreted
form
Ig heavy Igh- IGG IPI008305 HVM14_ P01758 1 0.95 2 186.498 0 0 0 230.376 0 63.7325 169.745 0 163.341
chain V VJ558 30.2 MOUSE 9176 035 3321 8647 9902

- 178 -
region
108A
Ras-related Rab43 SIG IPI008309 RAB43_ D3Z444 ENSMUS 69834 1 0.65 2 0 0 0 0 260.651 170.134 0 0 0 0
protein 32.1 MOUSE G0000003 0564 4226
Rab-43 0055
Septin-2 Sep-02 CS IPI008310 SEPT2_M F6WYM0 ENSMUS 18000 1 0.88 1 39.2721 0 0 0 0 0 0 0 0 34.6364
59.2 OUSE G0000002 7756 8282
6276
UPF0577 Kiaa132 TM IPI008455 K1324_M A2AFS3 ENSMUS 229722 1 0.27 1 0 83.6159 0 0 0 0 22.3924 0 0 0
protein 4 72.1 OUSE G0000004 5761 4972
KIAA1324 0412
Transmemb Tmem5 TM IPI008456 TMM56_ Q8CGF5 ENSMUS 99887 1 1.46 1 71.0824 0 0 0 0 0 104.040 0 0 0
rane protein 6 81.1 MOUSE G0000002 093 2818
56 8132
Dynein Dnahc1 CS IPI008499 F7ABZ6_ O08825 ENSMUS 1 0.89 7 0 234.595 0 1247.26 307.202 0 95.2937 504.050 997.772 0
heavy chain 0 53.1 MOUSE G0000003 7112 0855 6927 9532 0614 4899
10, 8011
axonemal
Protein- Tgm7 ENZ IPI008506 A2ART8_ A2ART8 ENSMUS 1 1.02 4 334.937 0 496.589 560.968 0 183.145 160.396 361.887 292.012 424.105
glutamine 42.1 MOUSE G0000007 1821 1996 9536 1437 7586 643 0303 7388
gamma- 9103
glutamyltra
nsferase Z
Ubinuclein- Ubn2 UK IPI008549 UBN2_M Q80WC1 ENSMUS 320538 1 0.50 3 1140.22 0 0 0 0 0 0 573.730 0 0
2 46.1 OUSE G0000003 0563 7535
8538
ubiquitin Usp48 ENZ IPI008551 UBP48_ Q3V0C5 ENSMUS 170707 1 0.96 2 58.6454 0 0 0 0 56.1711 0 0 0 0
carboxyl- 57.2 MOUSE G0000004 8646 7317
terminal 3411
hydrolase
48-like
Spectrin Spnb4 CS IPI008564 E9PX29_ E9PX29 ENSMUS 80297 1 0.53 2 0 144.325 0 0 0 0 0 0 0 76.4287
beta chain, 69.1 MOUSE G0000001 1471 3828
brain 3 1751
Uncharacte D7h11o UK IPI008572 CK016_M D3YXQ0 ENSMUS 57355 1 0.43 1 0 0 0 0 75.3075 32.4457 0 0 0 0
rized rf16 06.1 OUSE G0000003 5562 5139
protein 1022
C11orf16
homolog
Glyoxylate Grhpr ENZ IPI008575 GRHPR_ D6REG4 ENSMUS 76238 1 0.99 2 28.0942 119.118 65.0828 59.2470 0 0 0 90.5025 97.3583 80.6008
reductase/h 74.1 MOUSE G0000003 1584 8315 8509 9171 6322 6723 7398
ydroxypyru 5637
vate
reductase
Galactose- Gal3st4 ENZ IPI008581 Q3UTX9_ Q3TRU1 1 0.76 1 0 264.072 0 0 0 200.522 0 0 0 0
3-O- 86.1 MOUSE 4773 0948
sulfotransfe
rase 4
Ubiquitin Usp15 ENZ IPI008756 UBP15_ Q3TSV9 ENSMUS 14479 1 0.98 2 62.5125 42.5814 30.8318 0 0 57.7834 0 0 0 75.3554
carboxyl- 96.2 MOUSE G0000002 9314 8107 5279 2053 3752
terminal 0124
hydrolase
15
Dehydroge Dhrs7b ENZ IPI008773 DRS7B_ Q99J47 ENSMUS 216820 1 0.91 3 341.318 59.4263 0 0 0 0 174.668 0 0 188.795
nase/reduct 37.1 MOUSE G0000004 1001 1004 9541 9881
ase SDR 2569

- 179 -
family
member 7B
L-lactate Ldhc ENZ IPI008812 LDHC_M D3YVR7 ENSMUS 16833 1 0.30 4 0 0 231.886 0 0 0 69.3830 0 0 0
dehydrogen 67.1 OUSE G0000003 7803 8488
ase C chain 0851
Methyltrans Mettl16 ENZ IPI008814 MET16_ F8WHZ7 ENSMUS 67493 1 1.04 1 0 0 64.7146 0 0 0 0 0 67.6099 0
ferase-like 38.1 MOUSE G0000001 4898 9362
protein 16 0554
Chloride Clcn2 CNL IPI008823 CLCN2_ A9C437 ENSMUS 12724 1 0.90 1 0 58.3100 0 0 0 0 0 0 52.1918 0
channel 52.1 MOUSE G0000002 9555 9951
protein 2 2843
Eukaryotic Eif2a TF IPI008823 EIF2A_M D3YZZ6 ENSMUS 229317 1 0.01 1 0 0 0 3834.20 0 0 39.1793 0 0 0
translation 75.1 OUSE G0000002 2027 1586
initiation 7810
factor 2A
Mediator of Med12 TF IPI008863 MED12_ Q62006 ENSMUS 59024 1 2.79 3 0 0 160.447 0 0 0 0 447.065 0 0
RNA 27.1 MOUSE G0000007 247 5272
polymerase 9487
II
transcriptio
n subunit
12
Voltage- Cacna1 CNL IPI008954 CAC1A_ Q76N29 ENSMUS 12286 1 0.88 5 381.169 0 0 0 0 0 336.174 0 0 0
dependent a 03.1 MOUSE G0000003 924 9199
P/Q-type 4656
calcium
channel
subunit
alpha-1A
Protein DJ- Park7 CHA IPI008955 PARK7_ B2KFH7 ENSMUS 57320 1 0.97 5 69.7005 80.3074 92.7421 0 155.004 108.498 40.0545 58.7820 81.3543 96.7074
1, 18.1 MOUSE G0000002 5781 1217 8859 901 3126 2896 4118 5974 926
Parkinson 8964
disease
protein 7
homolog
Dedicator Dock9 MOD IPI008965 DOCK9_ E9QMR2 ENSMUS 1 0.43 1 221.530 0 0 0 0 95.6556 0 0 0 0
of 97.1 MOUSE G0000002 0697 1684
cytokinesis 5558
protein 9
Protein Pkdcc ENZ IPI009141 PKDCC_ Q5RJI4 ENSMUS 106522 1 1.06 2 35.8894 295.056 317.095 0 0 0 137.169 522.364 0 27.6370
kinase 48.1 MOUSE G0000002 0197 7868 6941 6542 9853 7467
domain- 4247
containing
protein,
cytoplasmic
Puratrophin Plekhg4 SIG IPI009182 F8VPS6_ Q8C0T8 ENSMUS 102075 1 1.15 1 0 409.532 1751.16 1207.22 0 1628.77 1165.79 1079.84 0 0
-1 43.1 MOUSE G0000001 4926 027 8544 9593 3568 9364
4782
Translation Tpt1 CS IPI009185 TCTP_M D3YU75 ENSMUS 22070 1 0.33 1 0 0 0 0 115.400 38.4818 0 0 0 0
ally- 99.1 OUSE G0000006 5295 6331
controlled 0126
tumor
protein
PDZ and Pdlim2 SCA IPI009187 PDLI2_M Q3UUU5 ENSMUS 213019 1 0.99 1 71.8474 0 87.1171 0 0 95.9370 62.2099 0 0 0
LIM 59.1 OUSE G0000002 7766 3864 7106 3721
domain 2090

- 180 -
protein 2
E3 Rnf123 ENZ IPI009284 RN123_M F7B5Z3 ENSMUS 84585 1 0.63 2 0 141.368 0 0 0 0 0 0 89.1983 0
ubiquitin- 96.1 OUSE G0000004 8603 5086
protein 1528
ligase
RNF123
Golgin Golgb1 CS IPI009298 E9PVZ8_ Q8CGE5 ENSMUS 224139 1 3.94 2 97.1048 0 0 0 0 0 383.058 0 0 0
subfamily 57.2 MOUSE G0000003 6364 4411
B member 4243
1
Solute Slc22a1 TP IPI009698 S22AH_ Q9D9E0 ENSMUS 59049 1 0.57 1 309.135 0 0 0 0 175.504 0 0 0 0
carrier 7 20.1 MOUSE G0000002 7749 3362
family 22 2199
member 17
Proteasome Psma6 ENZ IPI009702 PSA6_M E0CXB1 ENSMUS 26443 1 0.72 1 57.1571 0 0 0 0 0 41.0549 0 0 0
subunit 03.1 OUSE G0000002 4698 5013
alpha type- 1024
6
Protein Gm364 UK IPI009859 E9Q521_ E9Q521 ENSMUS 1 1.93 2 0 0 209.427 0 0 0 403.238 0 0 0
Gm3642 2 73.1 MOUSE G0000009 9557 5129
2133
Translocati Sec63 TP IPI009867 SEC63_M F7A8K1 ENSMUS 140740 1 0.46 1 0 0 0 0 341.208 156.797 0 0 0 0
on protein 54.1 OUSE G0000001 8297 1464
SEC63 9802
homolog
B-cell Bank1 SIG IPI009874 BANK1_ B0F3S4 ENSMUS 242248 1 0.41 2 0 541.996 0 0 0 0 221.415 0 0 0
scaffold 54.1 MOUSE G0000003 7225 1118
protein 7922
with
ankyrin
repeats
Histone- Setd1b TF IPI009874 SET1B_ Q8CFT2 ENSMUS 1 2.97 7 284.177 0 0 0 0 0 0 0 0 843.603
lysine N- 69.1 MOUSE G0000003 7776 6406
methyltrans 8384
ferase
SETD1B
Proliferatin Pcna CC IPI009876 PCNA_M E9Q7Z3 ENSMUS 18538 1 2.11 1 0 0 0 0 140.452 296.495 0 0 0 0
g cell 69.1 OUSE G0000002 9768 9966
nuclear 7342
antigen
Intraflagell Ift140 TP IPI009887 E9PY46_ E9Q8S7 ENSMUS 106633 1 1.66 2 0 0 0 0 996.128 0 0 1650.42 0 0
ar transport 19.2 MOUSE G0000002 9517 8365
protein 140 4169
homolog
Serine/thre Wnk4 ENZ IPI009887 WNK4_M F6Z709 ENSMUS 69847 1 1.92 1 0 0 25.0978 0 0 0 0 48.2598 0 0
onine- 54.2 OUSE G0000003 1637 9018
protein 5112
kinase
WNK4
Plakophilin Pkp4 MOD IPI009887 PKP4_M Q68FH0 ENSMUS 227937 1 0.94 1 110.964 0 0 0 0 0 0 104.437 0 0
-4 89.1 OUSE G0000002 5011 0537
6991
Uncharacte Kiaa138 UK IPI009891 K1383_M E9PXK6 ENSMUS 74393 1 0.31 1 0 0 0 0 204.586 63.5174 0 0 0 0
rized 3 11.2 OUSE G0000005 5703 8177
protein 0930
KIAA1383

- 181 -
Serine Serpina INH IPI009898 SPA3G_ E9Q499 ENSMUS 20715 1 0.75 3 1211.48 1221.33 756.288 0 0 0 282.144 0 1264.87 838.703
protease 3g 47.1 MOUSE G0000004 4687 6317 0184 0885 3011 8003
inhibitor 1481
A3G
40S Rps4x TF IPI009903 RS4X_M Q545F8 ENSMUS 20102 1 0.68 4 0 0 50.8939 0 0 0 34.5312 0 0 0
ribosomal 27.1 OUSE G0000003 093 777
protein S4, 1320
X isoform
Coiled-coil Ccdc33 UK IPI010078 CCD33_ E9QQ55 ENSMUS 382077 1 1.18 1 1203.91 1313.73 0 1943.33 0 649.127 1270.39 1193.15 1277.86 892.315
domain- 78.1 MOUSE G0000003 6655 6852 7407 9309 8536 2654 5431 1429
containing 7716
protein 33
Protein UK IPI010086 E9PYY3_ E9PYY3 ENSMUS 1 0.98 1 235.624 402.693 337.720 660.013 0 281.906 158.480 436.942 534.381 191.096
Gm1153 84.1 MOUSE G0000009 174 6557 787 7398 9779 5377 7661 5018 5936
1349|ENS
MUSG00
00009113
7

- 182 -
Supplementary Table S2. List of the statistically most significant proteins modulated in aortas of diabetic mice. Proteins which showed

both a high statistical significance (p<0.05) and fold-changes of at least 1.4 in aorta-samples from STZ-treated and untreated mice are listed.

Fold changes are the ratio of average ion counts per group. Fold changes of 1000 (STZ treated only) or 0.001 (control only) denote where a

protein was only found in one group. Functional classification and compartment localisation was based on the PADB functional classification

system and SwissProt keyword tags.

functional fold-
protein name gene name compartment UniProt ID p-value
classification change

Chaperone/chaperonin

T-complex protein 1 subunit zeta Cct6a cytoplasm TCPZ_MOUSE 0.54 0.032

Cytoskeletal, cell morphology, adhesion

Fibrous sheath-interacting protein 2 Fsip2 mitochondria FSIP2_MOUSE 0.05 0.045

Transgelin Tagln muscle TAGL_MOUSE 0.41 0.008

Cysteine and glycine-rich protein 1 Csrp1 nuclear CSRP1_MOUSE 0.43 0.016

Filamin-A Flna cytoplasm FLNA_MOUSE 0.58 0.019

Peripherin Prph Intermediate filament PERI_MOUSE 0.68 0.032

Alpha-actinin-2 Actn2 muscle ACTN2_MOUSE 34.30 0.045

Cartilage acidic protein 1 Crtac1 secreted CRAC1_MOUSE 1000.00 0.025

- 183 -
Development

Gasdermin-C2 Gsdmc2 unknown GSDC2_MOUSE 0.11 0.045

Alpha-crystallin B chain Cryab cytoplasm, nuclear CRYAB_MOUSE 7.37 0.046

Enzyme

Glycogen synthase kinase-3 beta Gsk3b cytoplasm, nuclear GSK3B_MOUSE 0.0001 0.025

endoplasmic

Estradiol 17-beta-dehydrogenase 12 Hsd17b12 reticulum DHB12_MOUSE 0.0001 0.025

Acetyl-CoA carboxylase 1 Acaca cytoplasm ACACA_MOUSE 0.0001 0.025

Aminopeptidase Q Aqpep transmembrane AMPQ_MOUSE 0.03 0.045

Lysine-specific demethylase 4C Kdm4c nuclear KDM4C_MOUSE 0.03 0.045

Fatty acid synthase Fasn mitochondria FAS_MOUSE 0.05 0.008

6-phosphogluconate dehydrogenase,

decarboxylating Pgd cytoplasm 6PGD_MOUSE 0.06 0.012

ATP-citrate synthase Acly cytoplasm ACLY_MOUSE 0.08 0.003

Transketolase Tkt cytoplasm, nuclear TKT_MOUSE 0.31 0.008

Pyruvate carboxylase, mitochondrial Pc mitochondria PYC_MOUSE 0.36 0.008

Glycerol-3-phosphate dehydrogenase [NAD(+)],

cytoplasmic Gpd1 cytoplasm GPDA_MOUSE 0.46 0.032

- 184 -
 endoplasmic

Liver carboxylesterase N Ces1c reticulum EST1C_MOUSE 0.55 0.008

Transaldolase Taldo1 cytoplasm TALDO_MOUSE 0.56 0.032

Alpha-enolase Eno1 cytoplasm ENOA_MOUSE 0.68 0.011

Isocitrate dehydrogenase [NADP], mitochondrial Idh2 mitochondria IDHP_MOUSE 2.22 0.008

Aldose reductase Akr1b1 cytoplasm ALDR_MOUSE 3.06 0.050

6.8 kDa mitochondrial proteolipid Mp68 mitochondria 68MP_MOUSE 1000.00 0.025

Sarcoplasmic/endoplasmic reticulum calcium

ATPase 1 Atp2a1 muscle AT2A1_MOUSE 1000.00 0.025

Aspartate aminotransferase, cytoplasmic Got1 cytoplasm AATC_MOUSE 1000.00 0.025

Microtubule-associated serine/threonine-protein

kinase 2 Mast2 cytoplasm MAST2_MOUSE 1000.00 0.048

Inhibitor

Alpha-1-antitrypsin 1-5 Serpina1e secreted A1AT5_MOUSE 0.32 0.012

Murinoglobulin-1 Mug1 secreted MUG1_MOUSE 0.59 0.032

Alpha-1-antitrypsin 1-2 Serpina1b secreted A1AT2_MOUSE 0.68 0.021

Modulator

Perilipin-1 Plin1 lipid droplet PLIN1_MOUSE 0.40 0.014

- 185 -
 F-box only protein 9 Fbxo9 unknown FBX9_MOUSE 0.48 0.025

Serine/threonine-protein phosphatase 6

regulatory ankyrin repeat subunit B Ankrd44 unknown ANR44_MOUSE 0.64 0.008

Mps one binder kinase activator-like 2A Mob3a intracellular MOB3A_MOUSE 1000.00 0.025

Receptor

Protein Vmn2r61, calcium-sensing receptor

related Vmn2r61 transmembrane E9Q4U2_MOUSE 1000.00 0.025

Scaffolder

14-3-3 protein beta/alpha Ywhab cytoplasm 1433B_MOUSE 0.64 0.028

14-3-3 protein epsilon Ywhae cytoplasm 1433E_MOUSE 0.67 0.019

14-3-3 protein zeta/delta Ywhaz cytoplasm 1433Z_MOUSE 0.67 0.032

14-3-3 protein gamma Ywhag cytoplasm 1433G_MOUSE 0.69 0.016

Signalling

Protein S100-A6 S100a6 cytoplasm, nuclear S10A6_MOUSE 0.28 0.034

Transcription/translation

Histone H2B type 2-B Hist2h2bb nuclear H2B2B_MOUSE 0.0001 0.025

Negative elongation factor B Cobra1 nuclear NELFB_MOUSE 0.19 0.020

Chromosome alignment-maintaining Champ1 cytoplasm, nuclear CHAP1_MOUSE 0.39 0.032

- 186 -
 phosphoprotein 1

Leucine-rich PPR motif-containing protein,

mitochondrial Lrpprc mitochondria LPPRC_MOUSE 0.52 0.008

Elongation factor 1-alpha 1 Eef1a1 cytoplasm, nuclear EF1A1_MOUSE 0.58 0.032

Histone H2B type 1-F/J/L Hist1h2bf nuclear H2B1F_MOUSE 6.65 0.045

RNA polymerase I-specific transcription

initiation factor Rrn3 nuclear RRN3_MOUSE 1000.00 0.025

Transmembrane

Transmembrane protein 229A Tmem229a transmembrane T229A_MOUSE 5.12 0.011

Transport

Tricarboxylate transport protein, mitochondrial Slc25a1 mitochondria Q8JZU2_MOUSE 0.0001 0.007

Myosin-11 Myh11 muscle MYH11_MOUSE 0.47 0.043

Solute carrier family 25 member 44 Slc25a44 mitochondria S2544_MOUSE 0.49 0.032

Fatty acid-binding protein, adipocyte Fabp4 cytoplasm, nuclear FABP4_MOUSE 0.51 0.016

Hemopexin Hpx secreted HEMO_MOUSE 0.54 0.032

Apolipoprotein A-I Apoa1 secreted APOA1_MOUSE 0.61 0.032

Platelet glycoprotein 4 Cd36 transmembrane CD36_MOUSE 0.64 0.032

Fatty acid-binding protein, heart Fabp3 cytoplasm FABPH_MOUSE 5.12 0.020

- 187 -
 Myoglobin Mb muscle MYG_MOUSE 5.85 0.032

Myosin-8 Myh8 muscle MYH8_MOUSE 6.26 0.043

Myosin-2 Myh2 muscle Q5SX41_MOUSE 7.50 0.033

Myosin light chain 3 Myl3 muscle MYL3_MOUSE 11.88 0.045

Myosin-1 Myh1 muscle MYH1_MOUSE 12.34 0.034

Myosin-4 Myh4 muscle MYH4_MOUSE 13.68 0.034

Myosin-13 Myh13 muscle B1AR69_MOUSE 16.77 0.045

Myomesin 2 Myom2 muscle Q14BI5_MOUSE 1000.00 0.025

Myosin regulatory light chain 2,

ventricular/cardiac muscle Myl2 muscle MLRV_MOUSE 1000.00 0.045

Unknown

SAM domain-containing protein C14orf174 Samd15 unknown SAM15_MOUSE 59.93 0.045

Cysteine-rich protein 3 Crip3 cytoplasm CRIP3_MOUSE 1000.00 0.007

Q3UR76_MOUS

Putative uncharacterized protein D030046N08Rik unknown E 1000.00 0.025

UPF0308 protein C9orf21 homolog C9orf21 unknown CI021_MOUSE 1000.00 0.025

- 188 -
Supplementary Table S3. Human disease analysis using OMIM database mining. Statistically significant molecules were used for OMIM

database mining. The descriptive terms from the OMIM database as well as the associated gene names are shown.

genetic genetic genetic genetic

Link: metabolic Link: development Link: fat Link: myopathy/muscle/vascular
link link link link
PYRUVATE CORONARY HEART HYPOALPHALIPOPROTEINEMIA,
CARDIOMYOPATHY, FAMILIAL
CARBOXYLASE PC DISEASE, CD36 PRIMARY; AMYLOIDOSIS, APOA1 SLC25A4
HYPERTROPHIC, 1; CMH1
DEFICIENCY SUSCEPTIBILITY TO, 7 FAMILIAL VISCERAL
MELNICK-NEEDLES
SYNDROME; MNS;
HETEROTOPIA,
PERIVENTRICULAR,
EHLERS-DANLOS
LEIGH SYNDROME, VARIANT; FG SYNDROME
FRENCH CANADIAN 2; FGS2;
AORTIC ANEURYSM, FAMILIAL
TYPE; LSFC // LRPPRC FRONTOMETAPHYSEAL FLNA MYH11
THORACIC 4; AAT4
MITOCHONDRIAL DYSPLASIA; FMD;
COMPLEX IV DEFICIENCY HETEROTOPIA,
PERIVENTRICULAR, X-
LINKED DOMINANT;
OTOPALATODIGITAL
SYNDROME, TYPE I/II;
OPD1/OPD2
MYOPATHY, DISTAL, WITH EARLY
TRANSALDOLASE
TALDO1 RESPIRATORY FAILURE, AUTOSOMAL MYH2
DEFICIENCY
DOMINANT
AMYOTROPHIC LATERAL SCLEROSIS 1;
PRPH
ALS1

- 189 -
Supplementary Table S4. Descriptive analysis of molecules regulated in diabetic aortas of STZ-treated mice.
Regulation Gene OMIM disease analysis
Literature knowledgebase associated with
System in diabetic gene Onthology potentially relevant in
diabetes
aorta (GO) analysis diabetes
Glucose and fatty acid metabolism
down Slc25a1 A depletion of solute carrier family 25
(mitochondrial carrier, citrate transporter),
member 1 (Slc25a1) in diabetic samples. This
molecule has been implicated in the control of
insulin secretion. Inhibition of Slc25a1 resulted
in a reduction of glucose-stimulated insulin
secretion and autocrine insulin secretion, and
further downstream to reduced glucose-6-
phosphate dehydrogenase activity 1.
down Fasn fatty acid Fatty acid synthetase (Fasn) is a biomarker for
pathway insulin resistance/type 2 diabetes, where
circulating levels of Fasn are inversely
correlated to the depletion of intracellular Fasn
2
.

- 190 -
down Hsd17b12 fatty acid Estradiol 17-beta-dehydrogenase 12
pathway (Hsd17b12) has been implicated to regulate
fatty acid synthesis (very long chain fatty acids
such as arachidonic acid) 3.
up Got1 fatty acid Aspartate aminotransferase, cytoplasmic (Got1),
pathway involved in a regulated pathway that controls
fatty acid homeostasis by promoting glycerol 3-
phosphate formation for fatty acid re-
esterification during fasting 4.
down Ces1c fatty acid Liver carboxylesterase N (Ces1c) hydrolyses
pathway fatty acid esters, catalyzing the ethyl
esterification of oleic acid to ethyloleate 5 and
is, apart from its metabolic carboxyesterase
function, also a growth hormone receptor gene
repressor 6.
down Eno1 Alpha-enolase (Eno1) is involved in glycolysis 7
and plays a part in various processes such as
growth control, hypoxia tolerance and allergic
responses 8, and was also shown to act as a

- 191 -
 transcriptional repressor 9.
down Gpd1 Glycerol-3-phosphate dehydrogenase
[NAD(+)], cytoplasmic (Gpd1) is a key enzyme
in gluconeogenesis and defects of this gene
cause hypertriglyceridemia 10.
down Plin1 fatty acid Perilipin-1 (Plin1) is a lipid storage protein and
pathway is involved in lipid accumulation 11.
down Pc fatty acid Pyruvate carboxylase, mitochondrial (Pc) is
pathway involved in glycolysis and fatty acid
metabolism 12 and insulin secretion 13.
down Tkt pentose- A down-regulation of transketolase (Tkt), a
phosphate protein involved in the pentose phosphate
shunt pathway, was shown to be involved in the
progression of diabetic nephropathy 14.
down Acly fatty acid ATP-citrate synthase (Acly) has a central role in
pathway lipid synthesis and mediates apoptosis 15.
down Pgd pentose- 6-phosphogluconate dehydrogenase,
phosphate decarboxylating (Pgd) is involved in
shunt carbohydrate degradation and the pentose

- 192 -
 phosphate pathway 16.
up Idh2 Isocitrate dehydrogenase [NADP],
mitochondrial (Idh2) is associated or interacts
with the pyruvate dehydrogenase complex and
has been shown to protect against apoptosis in
high glucose conditions 17.
down Acaca fatty acid Acetyl-CoA carboxylase 1 (Acaca) potentially
pathway modulates the PPAR pathway apart
from/through triglyceride synthesis 18 and fatty
acid synthesis 19.
Apoptosis
down Gsdmc2 Gasdermin (Gsdmc2) regulates apoptosis of the
gastric epithelium and are potential tumour
suppressors 20.
down Lrpprc severe neurological disorder Leucine-rich PPR motif-containing protein,
mitochondrial (Lrpprc) is involved in apoptosis
21
. Its normal function involves polyadenylation
and coordination of translation of mitochondrial
mRNAs through complexing with the

- 193 -
 mitochondrial RNA polymerase to activate
transcription of mitochondrial genes, such as
cytochrome oxidase Cox1 22.
down Ankrd44 Serine/threonine-protein phosphatase 6
regulatory ankyrin repeat subunit B (Ankrd44)
is a regulatory subunit of protein phosphatase 6
(Pp6) and might be involved in protein
degradation in response to TNFalpha 23.
down Fbxo9 F-box only protein 9 (Fbxo9) is believed to act
as a protein-ubiquitin ligase and might also be
involved in innate immunity 24.
up Fabp3 Fatty acid-binding protein, heart (Fabp3) is
involved in fatty acid transport, and over-
expression induces apoptosis 25. In pre-diabetic
conditions, both elevated levels of Fabp3 and an
associated thickening of the arterial intima-
media was observed 26, which is in accordance
with our results.
up Vmn2r61 Calcium-sensing receptor related protein

- 194 -
 (Vmn2r61) is potentially involved in apoptotic
processes through ERK/MAPK/PI3K pathways
27
.
down Col6a1/2/3 myopathy, apoptosis Collegens type 6 (COL6A1, COL6A2 and
COL6A3) are nonfibrillar collagens, and
deletion of type VI collagen plays a critical
protective role after myocardial infarction by
limiting infarct size, chronic apoptosis, aberrant
remodeling, and fibrosis, leading to preservation
of cardiac function 28.
down Vapb myopathy, spinal muscular Vesicle-associated membrane protein-
atrophy associated protein B/C (Vapb) is involved in
cellular calcium homeostasis regulation 29.
Neuronal control
down Prph neurodegenerative disorder Peripherin (Prph) is associated with diabetic
with asymmetric involvement neuropathy 30.
of the muscles
down A2m inhibitor Alzheimer’s disease Alpha-2-macroglobulin (A2m) is a global
involved in the protease inhibitor, and serum levels haven been

- 195 -
 response to positively linked to post myocardial infarction
stimulus in diabetic conditions 31.
down Nf1 neurofibromatosis, tumour Neurofibromin (Nf1) is a regulator of Ras
growth activity, and deficiency has been linked to
vascular inflammation 32.
Vascularisation
up Myl2 muscle Myosin regulatory light chain 2 (Myl2)
function expression has been shown to be up-regulated in
association with type 2 diabetes 33.
down 14-3-3 isoforms targeting and 14-3-3 mediates Rho kinase signalling and
cell cycle impacts on actin-cytoskeletal integrity 34.
down Eef1a1 Elongation factor 1-alpha 1 (Eef1a1) modulates
cytoskeletal remodelling 35.
down Myh11 muscle aortic aneurysm, degenerative Mutations of Myosin 11 (Myh11) have been
function changes in the aortic wall, shown to result in vascular pathologies driven
increased mean aortic root by insulin-like growth factor 1 and angiotensin
diameter, loss of smooth II 36 such as aortic aneurysms 37 and might also
muscle cells, aortic stiffness, involve the TGFbeta signalling pathway 38.
accumulation of basophilic

- 196 -
 ground substance
up Myh1/2/3/4/7/8/13 development development of muscle fibres The elevated expression of Myosins 1, 2, 3, 4,
of muscle 7, 8 and 13 are an indication of myogenesis.
fibres Myosin 13 (Myh13) belongs to the super-fast
myosin family 39, and a report has shown that
stroke causes an expression-shift of slow to fast
myosins 40.
down Csrp1 Cysteine and glycine-rich protein 1 (Csrp1) is a
smooth muscle marker and involved in the
actin-cytoskeletal modulation 41, regulating the
dynamic cell movements in cardiac mesoderm
42
, and shows a coordinated gene induction with
c-myc 43.
down Tagln Transgelin (Tagln) is an actin-associated
smooth muscle protein, which acts as a protease
(MMP9) repressor through ERK signalling
interference 44
up Atp2a1 Sarcoplasmic/endoplasmic reticulum calcium
ATPase 1 (Atp2a1) was shown to be associated

- 197 -
 with diabetes 2 45. Its normal function includes
translocation of calcium from the cytosol to the
sarcoplasmic reticulum lumen and it contributes
to calcium sequestration involved in muscular
excitation/contraction, and the observed up-
regulation can potentially be attributed to the
associated up-regulation of myosin isoforms.
down Champ1 Chromosome alignment-maintaining
phosphoprotein 1 (Champ1) is involved in
mitosis and a regulator of kinetochore-
microtubule attachment 46.
up Myom2 muscle Myomesin 2 (Myom2) is major constituent of
function the myofibrillar M band and binds myosin, titin,
and light meromyosin. It was described to be
involved in cardiomyopathy 47.
up Pgam2 development of coronary Phosphoglycerate mutase 2 (Pgam2) mutations
arteries are the cause of glycogen storage disease type
10, and this molecule has been described as a
biomarker for ischemic heart damage 48.

- 198 -
up Ldb3 cardiomyopathy LIM domain-binding protein 3 (Ldb3) is a
scaffolder, linking PKC-mediated signalling to
the cytoskeleton in muscle cells 49.
down Ptrf cardiac hypertrophy Polymerase I and transcript release factor (Ptrf)
is an important molecule in caveolae formation
and organization, and mutations cause
lipodystrophy, which is characterised by a near
complete absence of adipose tissue, extreme
insulin resistance, hypertriglyceridemia, hepatic
steatosis and early onset of diabetes 50.
down Slc25a4 cardiomyopathy ADP/ATP translocase 1 (Slc25a4) catalyses the
exchange of cytoplasmic ADP with
mitochondrial ATP across the mitochondrial
inner membrane. The expression is negatively
influenced by the PPARalpha signalling cascade
51
.
down Ttr cardiomyopathy Transthyretin (Ttr) is a thyroid hormone-
binding protein, that transports thyroxine. It has
been shown to be a useful predictor for

- 199 -
 cardiovascular outcome and mortality in
diabetic hemodialysis patients 52.
down Vcl muscle cardiomyopathy Vinculin (Vcl) is an actin filament binding
function protein involved in cell-matrix adhesion and
cell-cell adhesion. A reduced expression has
been linked to cardiomyopathy 53.
down Cd36 PPAR coronary artery disease Platelet glycoprotein 4 (Cd36), also known as
signalling Fatty acid translocase, binds long chain fatty
pathway acids and may function in the transport and/or
as a regulator of fatty acid transport. This
protein has been proposed as a target to prevent
cardiac lipotoxicity and insulin resistance 54.
down Taldo1 pentose- narrowing of the aorta Transaldolase (Taldo1) is a crucial protein in
phosphate the pentose-phosphate pathway, and an altered
shunt expression was observed in diabetes mellitus-
associated bladder dysfunction 55.
down Col1a2 severe morphological changes Collagen alpha-2(I) chain (Col1a2) is a fibrillar
in the aorta forming collagen, mainly found in fibrils of
tendon, ligaments and bones, and was shown to

- 200 -
 be a urinary biomarker in a rat model of STZ-
induced diabetes 56.
Hypertrophy/hypertension
down GSK3b targeting and cardiomyopathy Deletion of GSK-3beta in mice leads to
cell cycle, hypertrophic cardiomyopathy secondary to
insulin cardiomyoblast hyperproliferation 57. We could
pathway also demonstrate by immunohistochemistry that
levels of Gsk3b are substantially lower in
diabetic vessels.
down ApoA1 arterial hypertension Apolipoprotein A-I (ApoA1) is a lipid transport
molecule 58 that also functions as a potent
vasodilator 59 and was described as a risk factor
for hypertension and obesity 60.
down Flna muscle cardiac valvular disease Filamin-A (Flna), an actin-interactor, is
function involved in signal transduction of the insulin
receptor 61, stroke 62 and hypertension 63
possibly through the interaction with a calcium-
sensing receptor 64.
down S100a6 Protein S100-A6 (S100a6) might have a role in

- 201 -
 hypertension 65 and could function as calcium
sensor and contribute to cellular calcium
signalling as well as reorganization of the actin
cytoskeleton 66.
up Actn2 Alpha-actinin-2 (Actn2) is a known cytoskeletal
protein and anchors actin to a variety of
intracellular structures. Aberrant expression has
been shown to be associated with hypertension
67
.
up CryAB AlphaB-crystallin (CryAB) is the most
abundant small heat shock protein constitutively
expressed in cardiomyocytes and it suppresses
cardiac hypertrophic responses likely through
attenuating NFAT signalling 68.
up Myl3 muscle Myosin light chain 3 (Myl3) was reported to be
function up-regulated in a model of hypertension using
serotonin transporter over-expressing mice 69.
Oxidative stress
up Akr1b1 Aldose reductase (Akr1b1) is a key enzyme in

- 202 -
 diabetes-induced oxidative stress 70 and over-
expression results in higher susceptibility to
myocardial ischemic injury 71. NFB induces its
expression under high glucose conditions 72 and
recent findings suggest that it is also the
primary prostaglandin F synthase and possibly
of other signalling molecules 73.
down 14-3-3 isoforms targeting and 14-3-3 depletion causes oxidative stress,
cell cycle inflammation and remodelling process via
modulation of MAPK/NF-ĸB signalling
pathways 74.
up Mb Myoglobin (Mb), is a pro-oxidant which
supplies muscle with oxygen, and can cause
dose-dependent oxidative stress 75. The
observed up-regulation however might also be
due to elevated amounts of myosins.
down Mug1 Murinoglobulin-1 (Mug1) was reported to be
involved in oxidative stress 76.
down Hpx Hemopexin (Hpx) levels in serum are up-

- 203 -
 regulated by oxidative stress 77.
down Fabp4 PPAR Fatty acid-binding protein 4 (Fabp4) impairs the
signalling insulin-dependent nitric oxide pathway in
pathway vascular endothelial cells 78, and has been
shown to be associated with diabetes, diabetic
nephropathy, stroke and vascular inflammation.
It suppresses cardiomyocyte contraction 79.
Other signalling pathways
down Kdm4c Lysine-specific demethylase 4C (Kdm4c) is a
histone demethylase and indirectly regulates the
PPAR signalling pathway in adipocytes 80.
down Cav1 significant reduction of Caveolin-1 (CAV1) is a scaffolding protein
adipose tissue, extreme insulin within caveolar membranes and modulates G-
resistance, early onset of protein signalling cascades, and is an
diabetes endogenous eNOS inhibitor and regulator of
Erb B2 signalling 81.
Cell proliferation
down Eef1a1 A down-regulation of Elongation factor 1-alpha
1 (Eef1a1) expression might indicate an

- 204 -
 uncoupling of mRNA translation controlled by
the TGFbeta pathway 82.
down Serpina1b inhibitor Alpha-1-antitrypsin 1-2 (Serpina1b) has been
involved in the implicated in emphysema and the down-
response to regulation has been associated with a defective
stimulus epidermal barrier 83.

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Supplementary Figure S3. Metabolic pathway analysis of the STZ-induced

diabetic condition in mouse. The full metabolic pathways include

gluconeogenesis/glycolysis, fatty acid metabolism, pyruvate pathway, TCA cycle,

amino acid metabolism and inter-linking pathways. Signaling pathways are linked to

insulin-dependent signaling cascades.