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11-Dec-2017 3:53
Year 2015/2016
Organization Mechanical, Maritime and Materials Engineering
Education Master Biomedical Engineering
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1.
Year 2015/2016
Organization Mechanical, Maritime and Materials Engineering
Education Master Biomedical Engineering
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BM1104-15 Experimental design, statistics & human 2
Responsible Instructor Dr.ir. J.C.F. de Winter
Instructor Dr. D. Dodou
Contact Hours / Week 0/0/4/0
x/x/x/x
Education Period 3
Start Education 3
Exam Period 3
Course Language English
Course Contents Scientific method & experimental design
Human research ethics & bio-ethics
Measurement: pragmatic versus representational measurement, levels of measurement, differences between measuring height
and measuring IQ
Statistics: distributions, central tendencies, t test, correlation coefficient, reliability and validity
Probability: Bayesian versus frequentist statistics
Why most research findings are false, research bias
Publishing
Study Goals The aim of this course is to prepare BioMedical/BioMechanical MSc students to carry out independent research in a responsible
manner. The idea is to introduce students to the main principles in ethics, research design, and statistics. The theory taught in this
course will be of importance in students later scientific career.
Education Method Self-study (no lectures)
Reader Material on Blackboard
Assessment Homework assignments have to be completed before set deadlines. The assignments will be completed in pairs of two students.
Permitted Materials during None
Tests
Department 3mE Department Biomechanical Engineering
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BM1107 Anatomy and Physiology 4
Responsible Instructor Prof.dr. J. Dankelman
Instructor A.C.P. Geudon
Instructor Ir. K.R. Henken
Contact Hours / Week 2/2/0/0
x/x/x/x
Education Period 1
2
Start Education 1
Exam Period 2
3
Course Language English
Course Contents Content of Anatomy and Physiology:
1. Introduction to human physiology (human body, homeostasis, mass transport)
2. Cell physiology (plasma membrane, cytoplasm, nucleus, cell growth and reproduction)
3. Musculoskeletal system (bones, joints, musles)
4. Nervous system (nerve cells, neurophysiology, central nerve system, peripheral nervous system and reflex activity, autonomic
nervous system)
5. Endocrine system (hormones and endocrine organs)
6. Cardiovascular system: blood (blood cells, blood flow, blood pressure, vascular compliance, clotting, Newtonian flow).
7. Cardiovascular system: heart (anatomy, coronary circulation, cardiac muscle fibres, cardiac output).
8. Immune system (specific and nonspecific body defences)
9. Respiratory system (respiration, transport and exchange of oxygen and carbon dioxide, control mechanisms of respiration)
10. Digestive system & metabolism (anatomy, digestion and absorption)
11. Urinary system (anatomy, glomerular filtration, reabsorption, secretion, regulation mechanisms)
12. Reproductive system and pregnancy ( anatomy male and female reproductive system, foetal circulation, oxygen transport in
utero, umbilical cord, prematurity)
Study Goals The student is able to describe the anatomy and the function of several physiological systems from an engineering point of view.
The final grade of the weekly blackboard tests count for 10% and the final exam for 90% of the final grade for this course. A
minimum grade of 6 is needed on both the final grade of the weekly tests and the final exam to be able to pass this course.
Exam Hours Written exam - 3 hours
Department 3mE Department Biomechanical Engineering
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BM1240 Human Movement Control A: Musculoskeletal Mechanics 3
Responsible Instructor Prof.dr. H.E.J. Veeger
Instructor Dr.ir. A.C. Schouten
Instructor Prof.dr. F.C.T. van der Helm
Instructor Dr.ir. E. de Vlugt
Contact Hours / Week 0/0/4/0
x/x/x/x
Education Period 3
Start Education 3
Exam Period 3
4
Course Language English
Course Contents The skeletal system of living species provides the shape of the body and enables the transfer of forces required for body
movement. The muscles produce the forces to accelerate the body and also substantially contribute to the visco-elasticity of the
joints that is needed for stabilization of the skeletal system.
Central in this course are the kinematics of the human skeleton system and the mechanical properties of the human skeletal
muscles. The content of the course is strongly based on running research within the Delft Neuromuscular Control Laboratory
(NMC-Lab), with a focus on both fundamental aspects (physiology) and clinical applications (patho-physiology). Throughout
the course, knowledge about the physiological aspects will be formalized (modeling) and analyzed using model simulations with
Matlab/Simulink. Simulations are very useful when the scale of the system becomes larger, i.e. when the degrees of freedom
(number of joints and muscles) increase such as in the human shoulder girdle.
Study Goals After this course the student is able to:
* Describe the movement of bony segments of the human skeleton system with respect to each other using kinematic analysis
methods.
* To perform an analysis of the segment movement from recorded motion data (optical, camera).
* To understand the structure of the motion equations including the visco-elasticity as provided by the muscles.
* To simulate movements using musculo-skeleton models, both single joint and multi-joint (large scale) models such as the Delft
-Shoulder-Elbow Model (DSEM).
* To understand the benefits and drawbacks of backward and forward simulations.
* To calculate muscle forces from known joint positions (backward simulation) using different optimization techniques.
* To know the mechanical properties that are unique to skeletal muscles: force generation and impedance regulation.
* To understand the effect of non-linearities of the musculo-skeletal system on overall system behavior.
* To derive the mechanical impedance on the joint level from visco-elasticity of the muscles.
* To understand the role of joint visco-elasticity in the control of posture and movement.
* Understand the effect of different neuro-muscular disorders on functioning of joint in diseases such as stroke and Cerebral
Palsy.
Education Method * Lectures, 2 hours per week.
* Excursion to dissection room Amsterdam (cadaver study)
* Lecture material (slides), Matlab/Simulink programs for simulation
* Guest speakers. Experts from the fields of Human Movement Science, Muscle Physiology and the Medical Field.
Assessment * Assignments
* Final Examination (written)
Department 3mE Department Biomechanical Engineering
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SC4026 Control System Design 3
Responsible Instructor Dr.ir. A.J.J. van den Boom
Contact Hours / Week 4/0/0/0 (2 hours lectures and 2 hours exercises)
x/x/x/x
Education Period 1
Start Education 1
Exam Period 1
2
Course Language English
Course Contents State-space description of single-input, single-output linear dynamic systems, interconnections, block diagrams
Linearization, equilibria, stability, Lyapunov functions and the Lyapunov equation
Dynamic response, relation to modes, the matrix exponential
Realization of transfer function models by state space descriptions, coordinate changes, canonical forms
Controllability, stabilizability, uncontrollable modes and pole-placement by state-feedback
Application of LQ regulator
Observability, detectability, unobservable modes, state-estimation observer design
Output feedback synthesis and separation principle
Reference signal modeling, integral action for zero steady-state error
Study Goals By taking this course, the student
- will be able to master the introduced theoretical concepts in systems theory and feedback control designand
- will be able to practically apply these concepts to design projects and tasks
- will be capable to implement these concepts into model-based controller synthesis procedures through Matlab and Simulink
- and will be able to relate the learned concepts and techniques to other more specialized ones, to potentially integrate them by
taking adjacent courses.
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WB1413-04 Multibody Dynamics B 4
Responsible Instructor Dr.ir. A.L. Schwab
Contact Hours / Week 0/0/2/2
x/x/x/x
Education Period 3
4
Start Education 3
Exam Period none
Different, to be announced
Course Language English
Expected prior knowledge wb1113wb, wb1216
Course Contents In this course we will cover a systematic approach to the generation and solution of equations of motion for mechanical systems
consisting of multiple interconnected rigid bodies, the so-called Multibody Systems. This course differs from 'Advanced
Dynamics', which mostly covers theoretical results about classes of idealized systems (e.g. Hamiltonian systems), in that the goal
here is to find the motions of relatively realistic models of systems (including, for example, motors, dissipation and contact
constraints). Topics covered are:
-Newton-Euler equations of motion for a simple planar system, free body diagrams, constraint equations and constraint forces,
uniqueness of the solution.
-Systematic approach for a system of interconnected rigid bodies, virtual power method and Lagrangian multipliers.
-transformation of the equations of motion in terms of generalized
independent coordinates, and lagrange equations.
-Non-holonomic constraints as in rolling without slipping, degrees of freedom and kinematic coordinates.
-Unilateral constraints as in contact problems.
-Numerical integration of the equations of motion, stability and accuracy of the applied methods.
-Numerical integration of a coupled differential and algebraic system of equations (DAE's), Baumgarte stabilisation, projection
method and independent coordinates.
-Newton-Euler equations of motion for a rigid three-dimensional body, the need to describe orientation in space, Euler angles,
Cardan angles, Euler parameters and Quaternions.
-Equations of motion for flexible multibody systems, introduction to Finite Element Method approach, Linearised equations of
motion.
Upon request and if time and ability of the instructor allows, related topics are open for discussion.
Study Goals The student is able to find the motions of linked rigid body systems in two and three dimensions including systems with various
kinematic constraints, like there are: sliding, hinges and rolling, and closed kinematic chains.
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WB2301-5 System Identification and Parameter Estimation 7
Responsible Instructor Dr.ir. E. de Vlugt
Responsible Instructor Dr.ir. A.C. Schouten
Contact Hours / Week 2/2/0/0
x/x/x/x
Education Period 1
2
Start Education 1
Exam Period 2
3
Course Language English
Expected prior knowledge Basic control engineering (wb2104 and/or wb2207) and experience with Matlab (wb1443)
Summary System identification based on estimators of spectral densities (nonparametric black-box) and on discrete time domain models
(parametric grey-box). Translation of identified system dynamics into physical parameters using physical models (parameter
estimation). Application to open-loop and closed-loop systems. Estimation accuracy, perturbation signal design.
Course Contents System identification is an important tool to estimate the dynamics of a system using input and output data, and to gain more
insight into the system under investigation. During this course the mathematical background of system identification in both time
domain and frequency domain is given, including closed-loop systems (i.e. systems under feedback). Furthermore methods will
be presented to translate the identified system dynamics into physical parameters using physical models (parameter estimation).
During the course examples from both technical and physiological system (i.e. estimate the behavior of a driver or the dynamics
of a human joint) will be discussed.
Study Goals After this course the student must be able to:
1 Signals: design test signals to identify an unknown system dynamics
- signal power, sample frequency, observation time
- transient and continuous signals
- stochastic and deterministic (multisine) signals
2 Systems: estimate a nonparametric model of the unknown system from recorded signals
- recognize and identify open-loop and closed-loop systems
- identify linear and nonlinear models in the frequency domain (FRF) and time domain (IRF)
- least-squares error functions
- estimate linear time invariant (LTI) and time variant systems using subspace identification
- validation of the estimators
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WB2308 Biomedical Engineering Design 4
Responsible Instructor Dr.ir. D.H. Plettenburg
Instructor Prof.dr.ir. J.L. Herder
Instructor Dr.ir. G.J.M. Tuijthof
Contact Hours / Week 0/2/0/0
x/x/x/x
Education Period 2
Start Education 2
Exam Period 2
Course Language English
Course Contents In biomechanical engineering, the design specifications are fundamentally different from those in industry. Typically, precise
motion is much less critical than safety, force transmission or distribution, and energy-efficiency. Hence, a different design
approach is needed.
This course presents a design philosophy and a design approach, dedicated to rehabilitation technology and [orthopaedic]
surgery. These fields were selected because of human-machine interaction is inherent and vital. Illustrative examples will be
discussed by their entire design proces (system analysis, design approach, topology synthesis, system alternatives and
improvements, dimensional optimization, choice of components).
Topics addressed include: arm and hand prosthetics, arm orthotics and exoskeletons, control of prosthetics and orthotics,
minimally access orthopaedic surgery, arthroscopy, transmission of forces, influence of visco-elastic materials on the behaviour
of mechanical systems, static balancing, pneumatics, low-friction mechanisms, medical terminology.
Students will select a design assignment and perform a problem analysis, generate conceptual designs, and select a feasible one.
The assignment will be carried out in groups of around two students, where possible from different faculties, and is completed
with a presentation and a report.
Study Goals The student must be able to:
1.make a Problem Analysis of a given assignment in the field of medical or rehabilitation technology
identify the underlying cause of the problem as presented in the assignment
translate the result of 1a into technical Design Objectives without reference to any solutions
derive qualitative and quantitative Design Specifications from the Design Objectives, and categorize and prioritize these.
obtain and assess feedback on the Design Specification from Assignor
2.generate Conceptual and Embodiment Designs for the given assignment
select and apply appropriate Design Methodology and Design Methods
generate a variety [typically at least three] of Conceptual Designs
judiciously select the most appropriate Conceptual Design
obtain and assess feedback on the selected Conceptual Design from Assignor
transform the selected Conceptual Design into an Embodiment Design
demonstrate the plausibility or feasibility of the Embodiment Design
Education Method Lectures (2 hours per week)
Literature and Study "Upper Extremity Prosthetics. Current status & evaluation"
Materials Dick H. Plettenburg
VSSD, 2006, ISBN13: 978-90-71301-75-9
Assessment Design project
Remarks The course is completed with a conceptual engineering design project.
Percentage of Design 80%
Design Content Design methods and design tools, illustrated with examples, are the major part of the course. Furthermore several supporting
theories are discussed. Students are required to do a conceptual design study on real-life and actual problems.
Department 3mE Department Biomechanical Engineering
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WB2432 Bio Mechatronics 4
Responsible Instructor Dr.ir. D.H. Plettenburg
Instructor Prof.dr. F.C.T. van der Helm
Contact Hours / Week 0/0/2/2
x/x/x/x
Education Period 3
4
Start Education 3
Exam Period 4
Course Language English
Course Contents Biomechatronics is a contraction of biomechanics and mechatronics. In this course the function and coordination of the human
motion apparatus is the central focus, and the design of assistive devices for the support of the function of the motion apparatus.
Examples are assistive devices like an orthosis, prosthesis or Functional Electrical Stimulation of muscles. The goal is to provide
some function to patients with functional deficiencies.
Study Goals The student must be able to:
1.make a Problem Analysis of a given assignment in the field of the human motion apparatus and its interaction with an assistive
device
identify the underlying cause [pathology] of the problem as presented in the assignment
describe and explain the possible treatment options for the pathology of 1a
translate the result of 1a into technical Design Objectives without reference to any solutions
derive qualitative and quantitative Design Specifications from the Design Objectives, and categorize and prioritize these
assess feedback on the Design Specification from Assignor
2.optimize the assistive device application given in the assignment in energetical and control aspects
select and apply appropriate Design Methodology and Design Methods
generate a variety [typically at least three] of Conceptual Designs
judiciously select the most appropriate Conceptual Design
assess feedback on the selected Conceptual Design from Assignor
demonstrate the plausibility or feasibility of the Conceptual Design, with special emphasis to the patient benefits
Education Method Lectures (2 hours per week)
Literature and Study Course material:
Materials
A reader is available through Blackboard
D.H. Plettenburg
Upper Extremity Prosthetics. Current status & evaluation
VSSD (2006)
ISBN-13: 978-9071301759
Assessment Assignment + written exam
Remarks Students are requested to make one final assignment, which will be part of the examination.
Department 3mE Department Biomechanical Engineering
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Dr.ir. A.J.J. van den Boom
Unit Mech, Maritime & Materials Eng
Department Hybrid & Distributed Sys&Con
Telephone +31 15 27 84052
Room 34.C-3-220
Prof.dr. J. Dankelman
Unit Mech, Maritime & Materials Eng
Department Med. Instr.& Bio-Inspired Tech
Telephone +31 15 27 85565
Room 34.E-1-330
Dr. D. Dodou
Unit Mech, Maritime & Materials Eng
Department Med. Instr.& Bio-Inspired Tech
Telephone +31 15 27 84221
Room 34.E-1-270
A.C.P. Geudon
Unit Mech, Maritime & Materials Eng
Department Med. Instr.& Bio-Inspired Tech
Telephone +31 15 27 82977
Room 34.E-1-300
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Dr.ir. G.J.M. Tuijthof
Department Conversie
Room 34.E-3-320
Dr.ir. E. de Vlugt
Unit Mech, Maritime & Materials Eng
Department Biomech.&Human-Machine Control
Telephone +31 15 27 85247
Room 34.F-1-240
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