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DAFTAR ISI

Halaman
Halaman Sampul Luar................................................................................................................ i
Halaman Sampul Dalam .......................................................................................................... ii
Halaman Judul ........................................................................................................................ iii
Daftar Isi ................................................................................................................................ iv
Daftar Gambar ....................................................................................................................... v
Daftar Tabel .......................................................................................................................... vi
Bab I PENDAHULUAN ........................................................................................................ 1
1.1 Latar Belakang .................................................................................................................. 1
1.2 Rumusan Masalah ............................................................................................................ 3
1.3 Tujuan Penelitian .............................................................................................................. 3
1.3.1 Tujuan Umum .......................................................................................................... 3
1.3.2 Tujuan Khusus ...................................................................................................... 3
1.4 Kegunaan Penelitian......................................................................................................... 4
1.4.1 Kegunaan Akademis .............................................................................................. 4
1.4.2 Kegunaan Praktis ................................................................................................... 4
Bab II KAJIAN PUSTAKA, KERANGKA PEMIKIRAN DAN HIPOTESIS ..................... 5
2.1 Kajian Pustaka .................................................................................................................. 5
2.2 Kerangka Teori ................................................................................................................ 19
2.3 Hipotesis Penelitian ......................................................................................................... 19
Bab III SUBJEK DAN METODE PENELITIAN ................................................................. 20
3.1 Subjek Penelitian .............................................................................................................. 20
3.1.1 Kriteria Inklusi ....................................................................................................... 20
3.1.2 Kriteria Eksklusi ..................................................................................................... 20
3.1.3 Kriteria Drop Out ................................................................................................... 20
3.1.4 Pemilihan Sampel .................................................................................................. 20
3.1.5 Besar Sampel ......................................................................................................... 21
3.2 Metode Penelitian ............................................................................................................ 21
3.2.1 Rancangan Penelitian ........................................................................................... 21
3.2.2 Variabel dan Definisi Operasional Penelitian ........................................................ 21
3.2.2.1 Variabel Penelitian ..................................................................................... 22
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3.2.2.1 Definisi Operasional .................................................................................. 22

3.3 Cara Kerja ........................................................................................................................ 23
3.3.1 Persiapan ............................................................................................................... 23
3.3.2 Pengambilan Bahan Pemeriksaaan Laboratorium Pertama ................................... 23
3.3.3 Operasi Arthroplasti ............................................................................................... 23
3.3.4 Pengambilan Bahan Pemeriksaan Laboratorium Kedua ....................................... 24
3.3.5 Pengambilan Bahan Pemeriksaan Laboratorium Ketiga ....................................... 24
3.3.6 Prosedur Pengukuran Kadar Prokalsitonin ............................................................ 24
3.3.7 Prosedur Pengukuran Kadar C Reaktif Protein ...................................................... 26
3.4 Kerangka Penelitian ......................................................................................................... 28
3.5 Pengolahan dan Analisa Data ........................................................................................... 29
3.6 Tempat Penelitian ............................................................................................................ 29
3.7 Waktu Penelitian .............................................................................................................. 29
3.8 Aspek Etik Penelitian ...................................................................................................... 30
3.8.1 Prosedur Informed Consent ................................................................................... 30
3.8.2 Analisis Kelayakan Etik ........................................................................................ 30
3.8.3 Simpulan ................................................................................................................ 31
BAB IV HASIL PENELITIAN ............................................................................................ 32
4.1 Gambaran Umum Subjek Penelitian ................................................................................ 32
4.2 Karakteristik Demografi Subjek Penelitian ..................................................................... 32
4.3 Karakteristik Gambaran Kadar Prokalsitonin dan C Reaktif Protein Pasien .................. 34
4.4 Hubungan Kadar Prokasitonin dengan Luaran Mortalitas dan Morbiditas Pasien ......... 37
4.5 Hubungan Kadar C Reaktif Protein dengan Luaran Mortalitas dan Morbiditas Pasien 38
4.6 Lain- Lain ........................................................................................................................ 40
BAB V PEMBAHASAN ....................................................................................................... 41
BAB VI SIMPULAN DAN SARAN .................................................................................... 43
6.1 Simpulan .......................................................................................................................... 43
6.2 Saran ............................................................................................................................... 44
Daftar Pustaka ........................................................................................................................ 45

DAFTAR GAMBAR

Halaman
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Gambar 2 1. Sendi Panggul ...................................................................................................... 1

Gambar 2.2 Tulang Ilium, ischium, dan pubis ......................................................................... 6
Gambar 2.3. Anatomi tulang Femur proksimal ........................................................................ 7
Gambar 2.4. Perdarahan pada sendi panggul ........................................................................... 8
Gambar 2.5. Fraktur Femur bagian kepala ............................................................................... 9
Gambar 2.6. Klasifikasi Garden ............................................................................................. 11
Gambar 2.7. Klasifikasi fraktur throkanter ............................................................................ 12
Gambar 2.8. Prokalsitonin ...................................................................................................... 15
Gambar 2.9. Perbedaan kondisi tulang normal dan osteoporosis ........................................... 16
Gambar 4.1. Distribusi Penderita Berdasarkan Jenis Kelamin .............................................. 33
Gambar 4.2 Distribusi Penderita Berdasarkan Diagnosa ....................................................... 33
Grafik 1. Rerata Kadar Prokalsitonin Pasien .......................................................................... 35
Grafik 2. Rerata Kadar C Reaktif Protein .............................................................................. 35
Grafik 3. Kurva Perpotongan sensitivitas, spesifisitas dan kadar prokalsitonin luaran
kemerahan luka operasi .......................................................................................................... 37
Grafik 4. Kurva Perpotongan sensitivitas, spesifisitas dan kadar CRP luaran kemerahan luka
operasi .................................................................................................................................... 39

DAFTAR TABEL

Halaman
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Tabel 4.1 Karakteristik Subjek Penelitian............................................................................... 32

Tabel 4.2 Karakteristik Gambaran Kadar Prokalsitonin dan C Reaktif Protein .................... 34
Tabel 4.3 Perubahan Kadar Prokalsitonin dan CRP Post Operasi ......................................... 36
Tabel 4.4 Hubungan Kadar Prokalsitonin dengan Kemerahan pada Pasien ....................... 38
Tabel 4.5 Hubungan Kadar CRP dengan Kemerahan luka operasi pada pasien .................... 39