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Biotechnology Engineering

3rd Semester 4th Semester
Theory Contact Hours Theory Contact Hours

Code Subject L-T-P Credit Code Subject L-T-P Credit

BSCM1205 Mathematics - III 3- 1- 0 4 PCBT4202 Cell Biology & Genetics 3- 1- 0 4

BSCP1206 Physics II 3- 0- 0 3 BSCC1208 Chemistry II 3- 0- 0 3
BSCP1207 Physics of Semiconductor Devices BSMS1209 Material Sciences

BECS2208 Database Management System 3- 0- 0 3

BECS2212 C++ & Object Oriented Programming 3- 0- 0 3
HSSM3205 Organisational Behavior 3- 0- 0 3
HSSM3204Engg. Economics & Costing
HSSM3204 Engineering Economics& Costing 3- 0- 0 3
OR PCBT4203 Micro Biology 3- 1- 0 4
HSSM3205 Organisational Behavior

PCBT4204 Molecular Biology 3- 1- 0 3
BEME2209 Fluid Mechanics & Machines 3- 0- 0 3

PCBT4201 Biochemistry 3- 0- 0 3 Theory Credits 20

Theory Credits 19
Practical/ Sessional Practical/ Sessional

HSSM7203 COMMUNICATION AND INTERPERSONAL 0- 0- 3 2 BECS7208 Database Management 0- 0- 3 2

PCBT7204 Cell & Molecular Biology Lab 0- 0- 3 2
BECS7212 C++ & Object Oriented Programming Lab 0- 0- 3 2

PCBT7203 Microbiology Lab 0- 0- 3 2
PCBT7201Biochemistry Lab 0- 0- 3 2

PCME7202 Mechanical Engg. Lab 0- 0- 3 2


BSCM1205 Mathematics - III
Module-I (18 hours)

Partial differential equation of first order, Linear partial differential equation, Non-linear partial
differential equation, Homogenous and non-homogeneous partial differential equation with
constant co-efficient, Cauchy type, Monge’s method, Second order partial differential equation
The vibrating string, the wave equation and its solution, the heat equation and its solution, Two
dimensional wave equation and its solution, Laplace equation in polar, cylindrical and spherical
coordinates, potential.

Module-II (12 hours)

Complex Analysis:
Analytic function, Cauchy-Riemann equations, Laplace equation, Conformal mapping,
Complex integration: Line integral in the complex plane, Cauchy’s integral theorem, Cauchy’s
integral formula, Derivatives of analytic functions

Module –III (10 hours)
Power Series, Taylor’s series, Laurent’s series, Singularities and zeros, Residue integration
method, evaluation of real integrals.

Text books:
1. E. Kreyszig,” Advanced Engineering Mathematics:, Eighth Edition, Wiley India
Reading Chapters: 11,12(except 12.10),13,14,15
2. B.V. Ramana, “ Higher Engineering Mathematics”, McGraw Hill Education, 2008
Reading chapter: 18

Reference books:

1. E.B. Saff, A.D.Snider, “ Fundamental of Complex Analysis”, Third Edition, Pearson
Education, New Delhi
2. P. V. O’Neil, “Advanced Engineering Mathematics”, CENGAGE Learning, New Delhi


This one semester physics course is divided into three (Modules). Module-I deals with some aspects of
nuclear accelerators, Module-II introduces certain features of condensed matter physics and Module-III
deals with certain aspects of fibre optics and different types of lasers and crystal defects.

This unit covers the basic principles and applications of different types of accelerators and their important
Need for nuclear accelerators.
D.C. Accelerators: Cockcroft-Walton, Van de Graff, Tandem accelerators.
R.F. Accelerators: Linear accelerators, cyclotrons, electron accelerator, betatron.
Application of nuclear accelerators - Production of radio isotopes, Radiation processing of materials,
medical applications.
This unit covers the basic principle, properties of nanoparticles.
Properties, Classification & characterization of nanoparticles, fabrication of nanoparticles, Structure of
carbon nanotubes, types of carbon nanotubes, Properties of (Electrical, thermal) carbon nanotubes,
Quantum Dots.

Study of crystal structure by diffractions methods, Bragg’s condition for crystal diffraction, Laue’s
Condition, Miller indices, Reciprocal laltice, Geometrical Structure factor, Atomic form factor.
Energy bands in solids: Kronig-Penney model, allowed bands and forbidden gaps, elemental and
compound semiconductors.
Superconductivity: Superconductors and their properties, Meisner’s effect, Type-I and Type-II
superconductors, thermodynamic properties of superconductors, London equation, Application of

Defects in crystal:-Schottky and Frenkel defects, color centres, dislocation.
Laser: - Principle of lasing, Properties of laser, Ruby laser, He-Ne laser, semiconductor laser(construction
and working). Application of laser.
LED: Principle, construction of operation and application, Introduction to fiber optics, basic characteristics
of optical fibers, optical fibre communication system.
Books Recommended

Text books
(1) Concepts in Engineering Physics,Md.N.Khan
(2) Physics-II, B.B.Swain, P.K.Jena.

Reference Books
(3).Principles of Nanotechnology, Phani Kumar
(4) Physics-II, Randhir Singh, Shakti Mohanty,
(5) Physics-II, A.Serway,W.Jewett
(6) Solid state Physics, W.Ashcroft, N.David Mermin,
(7) Introduction to Solid State Physics, C.Kittel,
(8) Solid State Physics, Dan Wei

BSCP 1207 Physics of Semiconductor Devices

Module-I (10 Hours)
1.Introduction to the quantum theory of solids: Formation of energy bands, The k-space diagram (two
and three dimensional representation), conductors, semiconductors and insulators.
2.Electrons and Holes in semiconductors: Silicon crystal structure, Donors and acceptors in the band
model, electron effective mass, Density of states, Thermal equilibrium, Fermi-Dirac distribution function
for electrons and holes, Fermi energy. Equilibrium distribution of electrons & holes: derivation of n and p
from D(E) and f(E), Fermi level and carrier concentrations, The np product and the intrinsic carrier
concentration. General theory of n and p, Carrier concentrations at extremely high and low temperatures:
complete ionization, partial ionization and freeze-out. Energy-band diagram and Fermi-level, Variation of
EF with doping concentration and temperature.
3.Motion and Recombination of Electrons and Holes: Carrier drift: Electron and hole mobilities,
Mechanism of carrier scattering, Drift current and conductivity.

Module II (11 Hours)
4.Motion and Recombination of Electrons and Holes (continued): Carrier diffusion: diffusion current,
Total current density, relation between the energy diagram and potential, electric field. Einstein
relationship between diffusion coefficient and mobility. Electron-hole recombination, Thermal generation.
5.PN Junction: Building blocks of the pn junction theory: Energy band diagram and depletion layer of a pn
junction, Built-in potential; Depletion layer model: Field and potential in the depletion layer, depletion-layer
width; Reverse-biased PN junction; Capacitance-voltage characteristics; Junction breakdown: peak
electric field. Tunneling breakdown and avalanche breakdown; Carrier injection under forward bias-
Quasi-equilibrium boundary condition; current continuity equation; Excess carriers in forward-biased pn
junction; PN diode I-V characteristic, Charge storage.
6.The Bipolar Transistor: Introduction, Modes of operation, Minority Carrier distribution, Collector
current, Base current, current gain, Base width Modulation by collector current, Breakdown mechanism,
Equivalent Circuit Models - Ebers -Moll Model.

Module III (12 Hours)
7.Metal-Semiconductor Junction: Schottky Diodes: Built-in potential, Energy-band diagram, I-V
characteristics, Comparison of the Schottky barrier diode and the pn-junction diode. Ohmic contacts:
tunneling barrier, specific contact resistance.
8.MOS Capacitor: The MOS structure, Energy band diagrams, Flat-band condition and flat-band voltage,
Surface accumulation, surface depletion, Threshold condition and threshold voltage, MOS C-V
characteristics, Qinv in MOSFET.
9.MOS Transistor: Introduction to the MOSFET, Complementary MOS (CMOS) technology, V-I
Characteristics, Surface mobilities and high-mobility FETs, JFET, MOSFET Vt, Body effect and steep
retrograde doping, pinch-off voltage,

Text Books:
1. Modern Semiconductor Devices for Integrated Circuits, Chenming Calvin Hu, Pearson Education/Prentice
Hall, 2009.
2. Semiconductor Physics and Devices, 3rd Edition, Donald A. Neamen, Tata McGraw Hill Publishing Company
Limited, New Delhi.
Reference Books:
1. Fundamentals of Semiconductor Devices, M.K. Achuthan and K.N. Bhatt, Tata McGraw Hill Publishing
Company Limited, New Delhi.
2. Solid State Electronics Devices, 6th Edition, Ben. G. Stretman and Sanjay Banarjee, Pearson Educ, New Delhi.
3. Physics of Semiconductor Devices, 3rd Edition, S.M. Sze and Kwok K. Ng, Wiley India Pvt. Limited, New Delhi.
4. Physics of Semiconductor Devices, 2nd Edition, Dillip K. Roy, University Press (India) Pvt. Ltd., Hyderabad.
5. Solid State Electronics Devices, D.K. Bhattacharya and Rajnish Sharma, Oxford University Press, New Delhi.

BECS2212 C++ & Object Oriented Programming

Module I (08 hrs)
Introduction to object oriented programming, user defined types, structures, unions,
polymorphism, encapsulation. Getting started with C++ syntax, data-type, variables, strings,
functions, default values in functions, recursion, namespaces, operators, flow control, arrays and

Module II (16 hrs)

Abstraction mechanism: Classes, private, public, constructors, destructors, member data,
member functions, inline function, friend functions, static members, and references.
Inheritance: Class hierarchy, derived classes, single inheritance, multiple, multilevel, hybrid
inheritance, role of virtual base class, constructor and destructor execution, base initialization
using derived class constructors.
Polymorphism: Binding, Static binding, Dynamic binding, Static polymorphism: Function
Overloading, Ambiguity in function overloading, Dynamic polymorphism: Base class pointer,
object slicing, late binding, method overriding with virtual functions, pure virtual functions,
abstract classes.
Operator Overloading: This pointer, applications of this pointer, Operator function, member and
non member operator function, operator overloading, I/O operators.
Exception handling: Try, throw, and catch, exceptions and derived classes, function exception

Module III (08 hrs)

Dynamic memory management, new and delete operators, object copying, copy constructor,
assignment operator, virtual destructor.
Template: template classes, template functions.
Namespaces: user defined namespaces, namespaces provided by library.

Text Books:
1. Object Oriented Programming with C++ - E. Balagurusamy, McGraw-Hill Education (India)
2. ANSI and Turbo C++ - Ashoke N. Kamthane, Pearson Education

Reference Books:

1. Big C++ - Wiley India
2. C++: The Complete Reference- Schildt, McGraw-Hill Education (India)
3. “C++ and Object Oriented Programming” – Jana, PHI Learning.
4. “Object Oriented Programming with C++ “- Rajiv Sahay, Oxford
5. Mastering C++ - Venugopal, McGraw-Hill Education (India)
6. “Object Oriented Programming with C++”, David Parsons, Cengage Learning.

Break-even analysis-Linear approach. “ Managerial Economics”. TMH 5. Depreciation of capital assets. Mithani. Theory of production. General concepts on micro & macro economics. R. Text Books: 1. PHI 4. “ Engineering Economics”. 2. Depreciation policy. Preparation of cost sheet. Segregation of costs into fixed and variable costs. Sullivan and Wicks. Principle of economic equivalence. Bedworth and Randhwa. Annual worth method. Causes of depreciation. “Engineering Economics”. Law of variable proportion. D. PHI 2.Paneer Seelvan. McGraw Hill Education India. Cash flow diagram. “ Cost Accounting”. Law of returns to scale. Cost-benefit analysis in public projects. Lal and Srivastav. Sasmita Mishra. HSSM3204 Engineering Economics & Costing Module-I: (12 hours) Engineering Economics – Nature and scope. Demand function. Module-II: (12 hours) Time value of money – Simple and compound interest.M. Module-III: (12 hours) Cost concepts. functions of Reserve Bank of India. Future worth method. Law of demand and its exceptions. Pearson 3. Determination of equilibrium price under perfect competition (Simple numerical problems to be solved). Evaluation of engineering projects – Present worth method. internal rate of return method. Elements of costs. Elasticity of demand. Overview of Indian Financial system. Riggs. (Simple numerical problems to be solved) Banking: Meaning and functions of commercial banks. “Engineering Economics & Costing “. Reference Books : 1. Law of supply and elasticity of supply. The Theory of demand. Principles of Economics. Straight line method and declining balance method. Gupta. TMH . “ Engineering Economy”.

Hill. Leadership and Followership. Why Study OB Learning – Nature of Learning. TATA McGraw-Hill. How to be an effective Leader. Reference Books : 1. Khandelwal. Mary Ann Von Glinow. Training and Development. Types. Text Books : 1. Performance Appraisal. Organisational Behaviour. Organisational Behaviour. Uma Sekaran.L. Leader Behaviour theory. K. Confict-Nature of Conflict and Conflict Resolution.K. 2. Types. Pradip N. New Delhi. Maslow’s Need Hierarchy Theory. “Organizational Behaviour” India Tech 7.Aswathappa. Cultural Differences and Similarities. Module-III : Organization : Organizational Culture – Meaning and Definition.K. Organisational Behaviour. Motivation – Nature and Importance. Gateways and Barriers to Communication. Herzberg’s Two Factor Theory. Alderfer’s ERG Theory. Bhattachayya. Determinants of Personality. Perceptual Process. An Introduction to Transactional Analysis (TA). Groups in Organizations – Nature. How Learning occurs. Kavita Singh. D. McGraw-Hill. Importance of Perception in OB. 5. Introduction to Human Resource Management-Selection. Perception – Meaning and Definition. Keith Davis. Organizational Behaviour. K. Pearson . Effective Team Building. Individual and Interpersonal Behaviour in Global Perspective. Personality Traits. International Organisational Behaviour – Trends in International Business. New Delhi. Foundations of Individual Behaviour : Personality – Meaning and Defination. Personality and OB. Communication as a tool for improving Interpersonal Effectiveness.B. Oxford University Press 6. “Organizational Behaviour”. “Organizational Behaviour”. Planned Change and OB techniques. Culture and Organizational Effectiveness. Stephen P. Contingency Theory. Himalaya Publishing House. Why do people join groups. 3. Radha R Sharma” Organizational Behaviour” . McGraw-Hill. Learning and OB. 4. Steven L McShane. Evaluations. Incentives Organizational Change – Importance of Change. TATA McGraw. Group Cohesiveness and Group Decision- making Managerial Implications. Robbins. Theories of Leadership-Trait theory. “Organizational Behaviour”.Samantaray. Orientation.Srivastava & A. Leadership-Leadership & Management. Module II : Organizational Behaviour Process : Communication – Importance. HSSM 3205 Organizational Behaviour Module I : The study of Organizational Behaviour : Defination and Meaning. Prentice Hall of India 2.

F.Gasiorek. Positive displacement pump. differential equation of continuity. Text Books 1. Hydraulic Measurements: Water level measurements. Fluid static Pressure. Module II (10 Lectures) Fluid dynamics : Introduction. Acceleration of fluid particles. Scitech 6. hydraulic press. Engineering Fluid Mechanics by Garde et. An Introduction to Fluid Dynamics by G. construction and working principle of tangential.. Fluid Mechanics by J. hydraulic crane. compressibility and bulk modulus. J. Hydrostatic process on submerged surface. orifice. Ramamrutham Reference Books: 1. force on a vertical submerged plane surface. stability of immersed and floating bodies. BEME2209 Fluid Mechanics & Machines Module I (12 Lectures) Introduction : Scope of fluid mechanics and its development as a science Physical property of Fluid: Density. orifice meter. description of fluid flow. Elsevier 4. Construction and working principles of centrifugal type pumps. PHI 2. viscosity. Cambridge University Press 5. venturimeter. velocity measurements. Pascal’s Law. surface tension and capillarity. Module III (14 Lectures) Hydraulic turbines and pumps: Impulse and reaction turbines. Fluid Mechanics by Kundu. specific volume. notch and weir. hydraulic ram.K. radial and axial type turbines. Modi & Seth 2. hydraulic intensifier. al. absolute pressure. force on a horizontal submerged plane surface. classification of fluid flow. gauge pressure and vacuum pressure.Swaffield and L. current meter. discharge measurements. Fluid kinematics : Introduction. . Buoyancy and flotation. Power and efficiency of the pump. Mohanty. Hydraulics fluid machines and fluid machines by S. Hydraulic systems: hydraulic accumulator. specific weight. energy equation. manometer. Pearson Education. J. flow rate and continuity equation. atmospheric pressure. specific gravity.Jack. Fluid Mechanics and hydraulic machines. Pressure variation for incompressible fluid.B. Euler’s equation along a streamline. Introduction to Fluid Mechanics by Fox and McDonald. efficiency of turbines. Power of turbines.Batchelor. Fluid classification.M. pitot tube. Bernoulli’s equation. Archimedes’ principle.Douglas.K. determination of metacentric height. Fluid Mechanics by A.A. hydraulic torque converter. Willey Publications 3. hydraulic lift.

RNA. Glyco- proteins. Himalaya Publishing House. Enzyme Inhibition. Bio-complexes: Nucleoproteins. Glycogen metabolism. Biosynthesis of amino acids ( Valine. Phosphoglycerides. Protein Catabolism ( Genetic code and Protein synthesis). Sphingolipids. Lipoproteins and Vitamin complexes. Apozyme and Holozyme Text Book 1.R. Kinetics of of enzyme action. Enzymes: Properties of Enzyme. Protein Targetting. Rastogi. Ramachandran Plot. Hierarchy of protein architecture.) Metabolism-II: Metabolism of proteins: Properties of Amino acids. C. Biochemistry.Chatwal.) Introduction to Biomolecules: Structure and Function of Carbohydrates: Monosaccharide. β-Oxidation) and Energetics of lipid metabolism. Denaturation and Renaturation DNA.B. Module-III (12Hr. Biochemistry of Biochemistry by L. Structure and Function of Lipids: Saturated and Unsaturated Fatty Acids. Gluconeogenesis . Activation energy. Fundamentals of Biochemistry – Voet & Voet 4. ETS and Oxidative Phosphorylation. Metabolism of Lipids: Anabolism (Saturated and Unsaturated). Principle of Bio-Chemistry – Lehinger. Structure and function of Hormones. 5. Glycogen. Waxes and Sterol. Catabolism (α. Triacylglycerols. Minerals and Vitamins. Biological Oxidation and reduction reactions Metabolism-I: Introduction to metabolic processes. Optical Isomerism. Metabolism of Carbohydrates: Glycolysis. Biochemistry by Zubay. . Histidine and Glutamic Acid).) Principle of Bioenergetics: Bioenergetics and Thermodynamics. Serine. Nelson and Cox 2. Peptide bond. Structure and Function of Proteins: 20 Amino acids. Coenzyme. PCBT4201 Biochemistry Module-I (16 Hr. Structure and Function of Nucleic Acids: DNA.Powar & G. Polysaccharides (Starch. Metabolism Of Nucleic Acids: Catabolism and anabolism of purine and pyrimidine nucleotides. Oligosaccharides. Stryer 3. Protein Turnover. TCA Cycle. HMP pathway. Biochemistry. Phosphoryl group transfer and energy currency-ATP. Double Helix Model of DNA. Cellulose). Classification of Enzymes. 6. Module-II (12Hr. Mechanism of enzyme action.Oxidation. Tata McGraw Hill. 3-D structure.

Welcoming new entrants to the organization. Programs on generic programming using template function & template class. Practice activities for all four skills can be designed around these or similar situations. Programs on file handling.(1 class) 10. Gaining entry into an organization i.(1 class) 5. oral or written. Participating in group discussion (as part of the recruitment process) 2 In-house communication a. Some typical forms of work-related communication. Programs on dynamic polymorphism. Responding to the above ii. Facing an interview iii. Programs on dynamic memory management using new. Lab 30 hours This course will focus on communication in professional (work-related) situations of the kind that BPUT graduates may expect to encounter on entering the professional domain. Programs using inheritance.(1 class) 8.(1 class) . introducing the workplace culture etc. Subordinate / Junior Î Superior / Senior i. ii. praising / rewarding a subordinate or junior v Reprimanding / correcting / disciplining a subordinate/junior (for a lapse) . asking for an explanation etc. Programs on copy constructor and usage of assignment operator. Preparing job-applications and CVs ii.(1 class) 7. are listed below.(1 class) 4.(1 class) 9. HSSM7203 Communication & Interpersonal skills for Corporate Readiness Lab.(1 class) 2. 1. Reporting problems / difficulties / deficiencies Offering suggestions BECS7212 C++ & Object Oriented Programming Lab 1. Programs on exception handling . Expressing / recording appreciation. delete operators. Motivating subordinates / juniors (‘pep talk’) iii. b. ii.(1 class) 6. Programs on operator overloading. Briefing subordinates / juniors : explaining duties and responsibilities etc. Instructing/ directing subordinates/ juniors iv. Programs on concept of classes and objects. Superior/ Senior Î subordinate / junior (individual Î individual / group) i. Programs using static polymorphism.(1 class) 3.

Study of Cut-Sections of 2 stroke and 4 stroke Petrol Engine. Plummer. Determination of Km and Vmax of an enzyme catalyzed reaction. Verification of Bernoulli’s Theorem and its application to Venturimeter. Books: Introduction to Practical Biochemistry. Calibration of Bourdon Tube Pressure gauge and measurement of pressure using manometers. Assay of Enzyme activity: Protease from bacteria 9. . Separation of Amino acids by Paper Chromatography 6. Tata McGraw Hill PCME7202 Mechanical Engg. 9. 2. PCBT7201 Biochemistry Lab 1. Estimation of iodine Number and Saponification value of fatty acids 5. Spectrophotometric estimation of DNA using DPA method 3. Determination of Moment of Inertia of Flywheel 3. Determination of equilibrium of coplanar forces. 5. Separation of Sugars by Thin Layer Chromatography 7. 8. Determination of tensile strength of materials by Universal Testing Machine. Group C 7. Assay of Enzyme activity: Amylase from Plant tissue & Saliva 10. Lab Group A 1. Group B 4. 6. Determination of Cv and Cd of Orifices. Study of Cut-Sections of 2 stroke and 4 stroke Diesel Engine. Separation of Proteins by SDS-PAGE 8. Spectrophotometric/Colorimetric estimation of Protein using Lowry’s Method 2. Determination of Metacentric Height and application to stability of floating bodies. Spectrophotometric estimation of RNA using Orcinol Method 4.

7. Genetics.Mitosis and Meiosis. Ribosome). Cell Cycle. Taylor & Francis Group. .) Quantitative Inheritance: Polygenes and Multiple alleles. Inbreeding depressions. Linkage and Crossing over. Developmental genetic with reference to Arabidopsis and Drosophilla.) Principles of Inheritance: Chromosome theory of Heredity. Molecular Organization of Chromosome (Nucleosome concept). Cell Wall & Cell Membrane. Tata McGraw Hill 2. Effect of evolutionary forces on genetic equilibrium of apopulation. Cytoplasmic Inheritance. Cytoskeleton. Principles breeding in plants and animals. Molecular Biology of Cell – Alberts. Mendelism. Theory & Problems in Molecular & Cell Biology. ASM press Washington D. Mitochondria. Coincidence and Interference. Tata McGraw Hill. Introduction to QTLs and its inheritance.C. Heterosis and Hybrid vigour. Inc. Sex Determination. Robert Tamarin. Concept of Genetics by Klug. Changes in gene frequency. Mutation and Chromosomal Aberration. Genetic Equilibrium. Sinauer Associates. th 4 Semester PCBT4202 Cell Biology and Genetics Module-I (12 Hr. Stansfield. Genetic Drift. Cell-cell signaling( G-protein and Receptor mediated). The Cell Molecular approach. 3. Cell Organelles (Plastid. David R Hyde. Golgibodies. Non-Mendelian Gene Interactions (Epistasis. Pleiotropy). Cell Divisions. Geoffrey M. Haemophillia). Detection of QTLs Population Genetics: Hardy-Weinberg’s law. Principles of Genetics. Module-III (12Hr. Text Books 1. Tata McGraw Hill 4. Transposable genetic elements. Lethality. Nucleus.) Organization of Cell (Prokaryotic and Eukaryotic). Cooper. Garland Science. Genetic diseases in Human ( Colour blindness. Chromosome mapping. Module-II (16Hr. 6. Allelic Complementation.

Gordan-magnesium battery) Nickel cadmium battery Module III 1. CNG.V Liquid fuel: Classification of petroleum. Cracking.C jain and M. Engineering chemistry by R. Engineering chemistry by P.PHI Ltd 2. Basic components of battery.and SNagarajan. jain Reference Books: 1. Determination of B. poly acetylene). PHI Ltd 2.) Application of nano material in medicine.Nickel metal hydride battery) Reserve batteries(magnesium-copper. Engineering chemistry by mary.Water Technology: Hardness of Water : Types of hardness.polyurethanes.and ion exchange methods ) Desalination(electrodialysis. Passivation).polymer composite(carbon fiber) Preparation.Battery technology Introduction.jane. Disadvantage of hard water . Refining of petroleum . properties and application.D of water sample.O.II Module I 1.zeolite.O.D and C.Corrosion: Theories of corrosion . Water gas.C. Polymer: Types. Determination of hardness(EDTA method only). Dmadhavan. Fuels: Classification of fuels. Cathodic protection. Engineering chemistry by N Krishnamurthy . fuel cell. Units of hardness and their interrelation. Types of corrosion . 2. synthetic petrol. LPG .p vallinaygam.(synthesis. Kerosene gas Combustion Calculation.V&N. catalysis (only general idea) Text Books: 1. Lead acid & gel batteries) Alkaline batteries(zinc-air. Corrosion Control: (Proper design and fabrication procedure.venkaapaya. MODULE-II 1.PTFE Bakelite. Knocking and anti knocking.D.aluminium-air.Cengage learning publication 3. Factors affecting corrosion. 2.Engineering chemistry by Putti R. (Determination by Dulong’s formula). ozone.G.shultz . Carbon nano tube. Water softening technology (internal and external (limesoda.C. Batteries and cells.Chemical batteries(dry. BSCC1208 Chemistry .polycarbonate) 2 Nano materials Nano material. calorific value.Gopalan. chlorine.cetane and octane numbers . its Classification characteristics. Properties and uses of following polymer(polyethylene. .POLYMER . Sterilization of water by bleaching power. Unleaded petrol. Vikas publishing house. reverse osomosis. polymerization process and mechanisms Conducting polymers(poly aniline. chloramine.PMMA.vIjayasararhy . power alcohol Gaseous Fuel : Producer gas.

John Wiley & Sons. Magentic Properties of Materials : Dia. injection moulding. Processes and Material of manufacture : Lindberg.shackelford. 5. Ceramics : Types.Mc. applications 10.D. Optical Properties of Materials : Scattering. Raghavan . 9. 6. . Addison Wesley 3. Plastics – Types : Thermosetting and thermoplastics. Insulators. Transfer moulding. Vijaya M. Semiconductors. Ferro magnetic materials or Ferrites. Conductors. Rangarajan G.Aqueous corrosion-Electro chemical attack. extension moulding. Theory of Refraction and absorption.method of corrosion prevention Text book: 1. TMH 2. 2. TMH 2. Graw Hill. Rajendra V. Dielectric Materials : Microscopic Displacement of atoms and molecules in an external dc electric field. Conductivity of metals 3.corrosion by Gaseous reduction. 4. Materials Science. manufacturing procedure for fibre reinforced composites. Carbon fiber reinforced plastics.Composite Materials : Agglomerated Materials : Cermets. Metal matrix composites. Pyroelectrics. Type I and II super conductors. Applications of Supercoductors. Ferro electric material Piezoelectrics. 7. Temperature dependence. Band theory of solids. Materials Science & Engineering. Dielectric Materials as electrical isulators. Lasers. Dielectric _nitially_lity. Super Conductors – Zero resistivity. Material Science 4. Structure.Muralidhara . application of optical fibre. Reinforced Materials : Reinforced Concrete. Para and Ferro magenetic materials. application. fiber reinforced plastics. Materials Science. Intrinsic and extrinsic semiconductors. Van Vlack L. Refraction.. Optical fibres – Principle. Welding of plastics. Tufnol. Rubber types. Effect of mechanical stress on corrosion. Atomic Theory of optical properties. Quantum theory of free electrons.. Callister W. Laminated plastic sheets. Smith. Critical magnetic field and critical current density.. Thermal conductivity.Pearson(sixth edition) Reference Book: 1. Whiskers. MODULE – II 5. Mechanical properties. H. PHI. 11. 6.Introduction to Materials science for engineers by James. Dielectric Breakdown. Blow moulding.F. BSMS 1209 Material Science MODULE – I 1. Glass fibre reinforced plastics. Properties of composites. Theory of magnetism. Electron theory of solids : Free electron theory of metals.k. Marikani A. Classification of Engineering Materials. MODULE – III 8. Band theory of semi conductors Hall effect. Polarization and dielectric constant. Elements of Material Science and Engineering.Glavanic two –metal corrosion.Environmental Degradation:Oxidation-Direct atmospheric attack. Electrical conductivity. structure. Materials Science and Engineering. Comparison of magnetic behaviour and magnetic parameters of Dia.. S.. Engineering properties of materials.Madanapalli. Selection of Materials. Para and Ferro magnetic materials.

Network . Lossless design.Singh (Pearson Education) (3) Database management system by leon &leon (Vikas publishing House). Integrity Constraints and Data Manipulation Operations. SQL. Elsevier India Publications.Pearson Education References Books: (1) An introduction to Database System – Bipin Desai.Relational and Object Oriented Data Models. Korth (McGraw-Hill Education ) 2. Design & Application by S. Sam S. 4th Edition. Data models . “”. Dependency Preservation. Query Processing Strategy. Galgotia Publications (2) Database System: concept. Recovery techniques Text Books: 1. Data Independence. Fundamentals of Database System By Elmasari & Navathe. Data Definitions and Data Manipulation Languages. Wiley India (5) Database Modeling and Design: Logical Design by Toby J.Entity Relationship(ER).K.Data Abstraction. Normal Forms. Relational Database Design: Domain and Data dependency. Database Recovery System: Types of Data Base failure & Types of Database Recovery. Database System Concepts by Sudarshan. and Tom Nadeau. Locking and Timestamp based Schedulers. (4) Fundamentals of Database Management System – Gillenson. Module II : (12 hours) Relation Query Languages. Mapping ER Model to Relational Model. New Delhi . Module III: (10 hours) Transaction processing: Recovery and Concurrency Control. 2005. Teorey. Relational Algebra and Relational Calculus. Armstrong's Axioms. BECS2208 Database Management System Module I : (10 hours) Database System Architecture . Lightstone.

6. Tata McGraw Hill 3. Microbiology by Presscort. Thermofiles). Transposons. Conjugation and Transduction). Synchronous Growth and its Kinetics. Growth inhibitory substances. Microbiology.Bacteria. Microbiology by Atlas 9. 2. Viruses. Food poisioning.) Microbial growth and metabolism: Pattern of bacterial growth. Brock Biology of micro-organisms 5. Microbial genetics: Organization of bacterial and viral genome. Staining of bacteria (Gram’s. Classification of bacteria. DNA repair mechanisms in bacteria. Module-II (16Hr. Classical and Modern approaches of microbial taxonomy. Microbiology by Pelczar 4. Genetic analysis in bacteria. Phase Contrast and Electron). R. Medical Microbiology: disease causing bacteria. virus and fungi. Continuous culture and its growth kinetics. Methods of Microbiology. Anaerobic respiration. Monod’s Equation. Types of microbes associated with food spoilage. Growth kinetics. Energy transduction mechanism in bacteria. fungi and Viruses. Plasmids and Episomes.S.) Introduction to Microbial Kingdom. Microbiology of Air.Culture media. Genetic of bacteria by R. Text book of Microbiology by Stanier. Enerdoudorf. Food preservation methods. Establishment of pure culture. Mutation in Microorganisms. Baceriological analysis of water & water treatment. Capsule). Disinfectants and Vaccines Environmental Microbiology: Microbiology of water. Microbial Genetics. Snyder 8. Fluorescence. Antimicrobial agents. Microbiology of Milk and dairy products. Sterilization. Fungi and Yeast. Methanogens. Micrometry and Microscopy(Bright Field. Metabolism of carbohydrate in bacteria.s pathway and glyoxalate pathway. Acid Fast. Cyanobacteria and nitrogen fixation. Text Books : 1. Microbiology of sewage. Mol.) Food Microbiology: Microbiology of foods. Module-III (14Hr. PCBT4203 Micro Biology Module-I (10 Hr. Microbiology of extreme environments (Halobacteria.Freifelder 7. Genetic recombination in bacteria (Transformation. Antibiotics. Microbiology by Devis . Mehrotra.

Genome complexity. Books : 1. Termination). Cell Biology. m-RNA stability. Muton. . Translation machinery (t-RNA. Regulation of gene expression in prokaryotes and eukaryotes. Transcription process (Initiation. satellite DNA. Mol.) Transcription: Components of transcription machinery in prokaryotes and eukaryotes. DNA Replication: Models of DNA replication. Central dogma of molecular biology.) Genome Organization Prokayotes and Eukaryotes. pseudogenes. Cot curve analysis. Regulation of Gene Expression: Constitutive and Induced gene expression. Cistron. Elongation.Baltimore .the principle of translation. Transcription factors.operon). 2. Mol. Aminoacyl synthetase. Replication of Mitochondrial and Chloroplast genome. Gene structure in prokaryotes and Eukaryotes. Enzymology of DNA replication. Transcription factors. Gene Silencing Module-III (14Hr. Capping and poly (A) tailing. Variants of gene. Elongation. DNA methylation. Ribosome). Text Book of Molecular Biology By Padmanabhan and Shastri. Repetitive DNA. Principles of Mol. Overlapping genes and selfish DNA. 3. DNA as the genetic material. Himalaya Publishing House. PCBT4204 Molecular Biology Module-I (16 Hr. by Turner. DNA-protein interaction. DNA repair.Split genes. Biology . m-RNA processing. Recon. Recombinant DNA Technology – Watson 6. Introduction to recombinant DNA technology.value Paradox.) Translation: Genetic code.OS Prim Rose 5. C. Pre and Post transcriptional processing. Operon model (Lac-operon and Trp. Process of DNA replication (Initiation. Module-II (10Hr. Upadhyaya. Mol. Biology. 2. MOLBIO – Avinash & K. Termination). “Biology of Gene” – Watson 4. Nuclear genome and Organellar genome. Post translational modification of protein. Translation process. m- RNA editing. Molecular evolution (DNA based phylogenetic trees and its applications). DNA replication at the telomere.

Effect of gel concentration on solidification and migration of DNA sample 7. . Isolation and purification of RNA from plant/bacterial sample and its quantification using UV spectrophotometer. (1 class) 6. join. Programs on data recovery using check point technique. Programs on packages. Programs on ODBC using either VB or VC++. (1 class) PCBT7204 Cell and Molecular Biology Lab. 3. deletion. 6. Programs on database triggers. Programs on JDBC. (1 class) 10.. Elution of the DNA from the supplied gel and assess the integrity of the fragments. 8. updation using SQL.BECS7208 Database Management System Lab 1. (1 class) 7. Programs on embedded SQL using C / C++ as host language. (1 class) 3. purification of DNA from plant sample and its yield estimation. Isolation. Isolation. (1 class) 2. (1 class) 5. Concurrency control problem using lock operations. 5. Use of SQL syntax: insertion. (1 class) 4. Isolation of plasmid DNA and estimation its size using agarose gel electrophoresis. Isolation and purification of protein from the supplied sample and its quantification using UV spectrophotometer. purification of DNA from blood sample and its quantification using UV spectrophotometer. (1 class) 8. 4. purification of DNA from bacterial sample and its quality assessment using UV spectrophotometry. Restriction digestion of supplied DNA sample and estimate the molecular weight of the fragments resulted. Isolation. 10. 2. (1 class) 9. Chromosome preparation from onion root tip (Mitosis) & grasshopper testis (Meiosis). 9. Programs on procedures and functions. 1. Programs on join statements and SQL queries including where clause.

Media preparation and sterilization (Slant. PCBT7203 Micro Biology Lab 1. Establishment of pure culture by streak plate and serial dilution method. Micrometry: calibration of stage and ocular micrometer and measurement of microbial sample. 6. Soil & Milk) 5. Biochemical assay of microorganisms (Starch Hydrolysis. Stab and Broth culture) 4. Capsule staining. Water. Microscopy: Study of Compound. 9. Study the bacterial growth curve using spectrophotometer and viability assessment. 10. Chemical assay and MIC determination of antibiotics. 8. Isolation of micro organisms from natural habitats (Air. 2. Staining of microbial sample ( Gram’s Staining. Casein Hydrolysis and IMVIC test). ***************************************** . Antibiotic assay and estimation of Zone of inhibition. Fungal staining) 3. Phase contrast and Fluorescence Microscopes. 7.

ORISSA BIOTECHNOLOGY th 5 Semester 6th Semester Theory Subject Credit Credit Theory Subject Credit Credit Hrs Hrs HSSM3304 Biostatistics 3-0-0 3 HSSM3303 Environmental Engg. and Safety 3-0-0 3 PCBT4301 Immunology and immunotechnology 3-0-0 3 PCBT4304 Bioinformatics 3-0-0 3 PCBT4302 Genetic Engineering and r-DNA 3-0-0 3 Technology PCBT4307 Industrial Microbiology and 4-0-0 4 Enzyme technology PCBT4303 Upstream Process Engineering 3-0-0 3 PCBT4305 Plant Biotechnology 3-0-0 3 PCBT5304 Biochemical reaction Engineering 4-0-0 4 PCBT4306 Downstream process Engineering 3-0-0 Free Elective. 0-0-3 2 PCBT7306 Downstream process 0-0-3 2 Engineering & Enzyme tech. Professional Elective. designing PEBT5301 Nano Biotechnology Total Total 19 19 Practical / Sessionals Practical / Sessionals PCBT7303 Upstream process engg. BIJU PATNAIK UNIVERSITY OF TECHNOLOGY. Lab. PCBT7302 r-DNA technology lab lab 0-0-3 2 PCBT7301 Immunotechnology lab PCBT7305 Plant Biotechnology & 0-0-3 2 0-0-3 2 Industrial Microbiology lab Total PCBT7304 Bioinformatics lab 6 0-0-3 2 Total 6 25 25 **Industrial / Institutional visit should be made ( at least one visit per semester) .(Any one) 3-0-0 3 3 PECH5304 Process Instrumentation. PEBT5302 Molecular modeling and drug PEIT5302 Data mining and Data ware housing. PEBT5303 Biomaterials PECS5304 Theory of Computation.Any one 3-0-0 3 PCBM4302 Signal & System.

IPR in biotechnology. . 3 3 9 20-25 Project . 24 25-30 including Math. . Bioinformatics 3. 1. 47 30-35 & Comp. . 2 3 5 5-10 Vivavoce. .. 27 25-30 Social & Mangt. Genetic Engineering and r-DNA Technology 2. . Professional . . Humanities. . . Study Engg. 4 10 6 3 23 25-30 Electives Free Electives . 5 15 16 13 6 6 59 45-55 Core Professional . Engg. List of Free Electives to be floated by Biotechnology Stream. 4 4 7 3 3 3 3 . Basic Science 7 7 7 3 . TA 17 17 8 5 . & Training Total 28 28 27 26 25 25 22 23 204 . 3 . 3 .Tech Syllabus in BIOTECHNOLOGY Semester 1st 2nd 3rd 4th 5th 6th 7th 8th Total Recommended as per Dayaratnam Subjects Committee. . Sc. 2 8 10 10-15 Seminar. Biomaterials 4. . . Molecular modeling and drug designing 6. Biosafety & Bioethics Distribution of Credits for B. Nano Biotechnology 5. . . . . .

synthesis of antibody and secretion. T. 2. hyper sensitivity.M. Coefficient of variation. Module-III Immune response and tolerance: Regulation of immune response.way and two-way classifications with single observation per cell. Major Histocompatibility Complex (MHC) Module-II: Antigen processing and presentation. polyclonal and monoclonal antibody. Immunology: Lydyard. complement system. their properties and uses. Immunotechnology by A Khan. Approaches for correcting immune dysfunction. Essential Immunology: Roitt. sample space.C.. Ltd. H. Various definitions of probability. immune tolerance. Fanger. independent and dependent events. cells of immune system. Tests of significance: Chi-square. linear and quadratic regression. Kar. Measures of central tendency: Mean. Simple random sampling without replacement. Median and Mode and their relationship. Quartile deviation. autoimmunity. 3. Thatoi. PHI learning Pvt.. Correlation and Regression.W. Duncan’s multiple range test. Primary and secondary lymphoid organ. I.. Module-II: Probability: Random experiment. Random variables (discrete and continuous). Skew ness and Kurtosis. (1997) Freeman W. tabulation graphical and diagrammatic representation of numerical data. A. Probability distributions: normal. UK. Analysis of variance: One. Standard deviation. Classification. Dysfunctions of immune system and their modulation. Mean deviation. New Delhi . J. oxford. PCBT4301IMMUNOLOGY & IMMUNOTECHNOLOGY(3-0-0) Module-I: The origin of Immunology. 3. India-Tech publication. Designing of Experiments-Random block design and Split plot design.(1997) Blackwell Scientific. immunoglobulin and antibodies.. events. P. Poisson and their application. M. Pearson Publication Reference: 1. Biostatistics: Rao KS. antigen. antigen-antibody reaction. Binomial. Concept of standard error..M. Probability density functions and its properties. Introduction to Biostatistics & Research Methods: Sundar Rao PSS & Richard J. addition and multiplication theorems of probability. Himalaya Publishing House Reference: 1. Himalaya Publishing House 2. 1st Ed. Text Books: 1. Vaccinology. 3rd Ed. mutually exclusive events. Monoclonal antibody technology.. HSSM3304 BIOSTATISTICS (3-0-0) Module-I: Introduction and definition of Biostatistics. Oxford. Collection. Definition of simple random sample. z and f-distributions. 4. H. Concept of variables in biological systems. Biostatistics: Arora and Mohan. graft versus host reaction. 9th Ed. types of immunity. Whelan. Molecular basis of antibody diversity. Immuno. Microbiology and Immunology by B K Patnaik. Text Books: 1.deficiency and immuno- proliferate diseases. Module-III: Concept of populations and sample. Molecular basis of Immunology. student’s t. humoral and cell mediated immunity.N. Viva Books. Measures of dispersion: Range. Immunology: Kuby.

Molecular cloning (Vol. Ribozyme Technology. gene tagging.principle and manufacturing process. H S Chawla. SCAR. BAC. Cloning of differentially expressed gene. EST). Module-II: Basic concept of gene cloning. Blackwell . DNA& RNA Markers. gene mapping. Ligase and other modifying enzymes. Blotting techniques: Southern. bacteriophage. Module-III: Molecular markers.genomic and c-DNA. SNP. PCBT4302 GENETIC ENGINEERING & R-DNA TECHNOLOGY (3-0-0) Module-I: Basic principle of DNA isolation and purification. DNA micro arrays and Chips.Plasmid. Spurr N & Young TD. In vitro transcription and translation. T A Brown. Gene cloning and DNA Analysis. Genetic engineering regulations and safety guidelines.II). Physical mapping. cosmid. bacteria and yeast based expression vector. Site directed mutagenesis. RNA interference: Antisense RNA. RAPD. Linker. Principle and methodology. YAC. Oxford University Press 2. Western. Nucleic acid hybridization. Gene library. Adapter and MCS. contig library. DNA finger printing and DNA foot printing. Application of molecular markers: in diagnostics. ICRF Hand book of genome analysis. Expression vectors: basic concept. Black well publishing. AFLP. Genome projects: Human. Principle of gene manipulation and genomics. Rice.Types (RFLP. CSH Press. SSR. si RNA and mi RNA. 2. Sambrooks et al. Dot and Slot..I. Reference 1. Expression of heterologous gene. Polymerase Chain reaction. Northern. Plant Biotechnology. Cloning of interacting gene: two hybrid and three hybrid assay.. Gene therapy and its applications. Restriction endonuclease. Gene cloning vectors. Text Books: 1. DNA vaccines and rDNA products. DNA Sequencing. Black well publishing 3. Primerose et al. Gene knock out strategies. Map based cloning of gene and cloning of QTLs.II.

7. Description of adsorption and absorption processes and their applications. R. Leaching. size reduction. friction factor. laminar flow in pipes. Heat transfer by forced convection. temperature concentration diagram. Text Books 1. Transport processes and unit operations . Unit Operations of Chemical Engineering 2. relative volatility. principles of filtration. vacuum and steam distillation. Overall stage efficiency. Differential distillation. Hollman. effect of roughness. Heat transfer. Maus and Andersen. compound resistance in series. heat transfer from condensing vapors. Properties and handling of particulate solids. triangular graphical representation. Treybal. McCabe. 6. 3. 5. Transportation and Metering of Fluids: pipe fittings and valves. enthalpy concentration diagram. pump work in Bernoulli equation. Ternary liquid equilibria. solid-liquid equilibrium. equipments used in solid- liquid extraction. Reynolds numbers and friction factor relationship. heat flow through a cylinder. Hagen-Poiseuille equation. nature of adsorbents adsorption equillibria. Mass Transfer Operations 4. flash vaporization. Single and multiple contact. thermal conductivity. one dimensional unsteady state heat conduction. continuity equation. Geankoplis. Principles of Unit Operations. concept of theoretical or ideal stages and multistage continuous operation. Badger and Banchero. Introduction to Chemical Engineering. Clump. filmwise and dropwise condensation. Foust. Heat transfer by convection: Thermal boundary layer. Flow of Incompressible Fluids: Fluid flow in pipes. screening and particle size distribution.E. orifice meter. heat transfer by natural convection. Fick’s law of diffusion. flow in boundary layers. Wenzel. Steady state conduction. Heat Transfer equipments like evaporators and heat exchangers and autoclaves of different types. Smith and Harriot. types of adsorption. Foust et al. blower and compressor. Module -II: Heat Transfer concepts and applications Heat transfer by conduction in solids: Fourier’s Law. Reynolds number and transition from laminar to turbulent flow. centrifugal pumps. Roult’s Law. Bernoulli equation. azeotropes. 8th Ed. positive displacement pumps. pitot tube and rotameter. Principles of Unit Operations. heat transfer from extended surface. Turbulence and its nature. friction factor charts. flow measuring devices such as venturimeter. centrifuges. Phase diagram. PCBT4303 UPSTREAM PROCESS ENGINEERING (3-0-0) Module-I: Fluid Transfer concepts and applications Basic Equations of Fluid Flow: Newtonian and non-Newtonian fluids. Drag force and terminal settling velocity. Module -III: Mass Transfer concepts and applications Diffusion concepts. Ideal solution.

noncompetitive and uncompetitiveMichaelish-Menten kinetics. the determination and significance of kinetic constants.Wiley Eastern Ltd. principles of enzyme inhibition – Competitive. Ricchardson. representation of elementary and nonelementary reactions. inhibition by foreign substances. Foggler. heats of solution and mixing. Prentice Hall (l) 6th Ed. Coulson & Richardson’s Chemical Engineering. advantages and disadvantages of packed bed and fluidized bed catalytic reactors. CSTR and PFR. 1998. kinetics of competitive and noncompetitive inhibitions.First Indian ed. rate equation. interpretation of constant volume batch reactor. kinetic models for nonelementary reactions. Text Books 1. first. half life period. Fundamentals. 2. experimental methods for finding rates.G. Himmelbalu. Kinetics of homogeneous reactions: classification of reactions. auto catalytic reaction. speed of reaction. 4. temperature-dependent term of a rate equation.. Thermodynamics for Chemical Engineers. Watson & Ragatz. Biochemical reaction systems: Cell and enzyme fermentation. Monod’s model of growth kinetics. Design for single reaction: size comparison of single reactors. Elements of Chemical Reaction Engineering . J. irreversible reaction in parallel and series. Design of multiple reactions in batch. energy balance. MGH. – derivation of Michaelis-Menten equation. pore diffusion resistance combined with surface kinetics. Chemical process Principles (Part I & II).Ltd. performance equations for reactors containing porous catalyst particles. Chemical Reaction Engineering. Kinetic interpretation of batch reactor data for single reactions: interpretation of variable volume batch reaction data for zero. second and third order reactions. reaction rate. equal and different size of mixed reactor in series.. Houge.Volume 3 (Chemical and Biochemical Reactors and process controls) ed. D. kinetic expressions of fermentation. recycle reactor. order and molecularity. steady state CSTR and plug flow reactors and their use for kinetic interpretation. data for zero. material balance with chemical reaction. concentration-dependent term of rate equation. Smith & Vanness. Bailey & Oils. Briggs-haldane relationship. PCBT5304 BIO-CHEMICAL REACTION ENGINEERING (4-0-0) Module I: Material. Ideal batch reactor. Asia Publishing House. microbial fermentation. first and second order reactions. Levenspiel. energy balance and concepts of reaction engineering Material Balance & Energy Balances: Mathematical requisites – use of log-log and semi-log graph paper. 5. finding the best system for given conversion. rate constant. activation energy and temperature dependency. Peacock. heat of reaction and its temperature dependence. Module II: Reaction engineering of batch and continuous reactors Kinetic analysis of batch reactor data: Integral and differential methods for analyzing kinetic data. Biochemical Engg. graphical differentiation and graphical integration.. enthalpy changes. rate equation for surface kinetics. Basic Principles and Calculations in Chemical Engineering. 6. O. use of psychometric charts. Module III: Heterogeneous reactions and Biochemical reactions Reaction catalyzed by solids: introduction to heterogeneous reactions.F. Lineweaver-burk and Eadie-Hofstee plot. porous catalyst particles. MGH 7. adiabatic flame temperature. 3. material balance without chemical reaction. Asian Student Edition. plug flow reaction in series and/or parallel. Asian Books Pvt. triangular diagram. batch fermentor and mixed flow fermentor. Kinetics of Enzyme catalyzed reactions for free and immobilized enzymes.

Wiley Eastern Ltd. Elastic pressure transducers. Quantity flowmeters. sight glass. Temperature scales. J. S. Mani. Methods of composition analysis: Spectroscopic analysis. Hook-type level indicator. Principles of Measurement Systems. Pressure measurement: Pressure. Maintenance and repair of pressure measuring instruments. TMH. Indirect methods. Inferential flow measurement. PECH5304 PROCESS INSTRUMENTATION (3-0-0) Module . Direct methods. Electrical methods. S. Calibration of flowmeters. C. Force-balance pressure gauges. Methods of pressure measurement. Level measurement: Methods of liquid level measurement. Selection of flowmeters. Module – III Temperature measurement: Temperature. Air purge system. Pressure gauge method. Industrial Instrumentation. Eckman. Displacer level detectors. Hydrostatic pressure type.K. Emission spectroscopy. P. D. Expansion temperature. S. Pressure switches. Module – II Flow Measurement: Methods of flow measurement. Devices and Systems. Rangan. Electrical temperature instruments.Singh. Manometers. 2. Longman 4. Absorption spectroscopy. Air bellows.I Basic concepts and qualities of measurement. Calibration of pressure measuring instruments. . Industrial instrumentation and control. Electrical pressure transducers. Mass spectroscopy Text books and References : 1. Sarma and V. V. Instrumentation. Methods of temperature measurement. Liquid purge system. Tata Mc Graw-Hill. P. G. Filled-system thermometers. Float-type level indicator. Pyrometers: Radiation and optical. 3. Troubleshooting. Mass flowmeters. Bentley. R. Measurement of vacuum.

2. Signals and Systems – A Nagoor Kani. Oxford. and Symmetry Properties.1.2. TMH Reference Book: 1. Discrete-Time Systems : Input-Output Description. Principles of Linear Systems and Signals. Oxford .3. 4. Simple Manipulation. 4th Edition. Properties of Convolution.5. Classification. Linearity and Superposition. G. Block Diagram Representation. R. Response of LTI Systems. Algorithms and Applications by J. Proakis and D.4.4. Selected portions from Chapter 4 (4. Selected portions from Chapter 10 (10. Implementation of Discrete-Time Systems. Linearity.4. 7. Fundamentals of Signals and Systems .2.1. Selected portions from Chapter 8 (8.5. 8. Pearson. J. 2. 2. Properties of the Fourier Series.3. Interconnection. Rao. 2.6.6. Additivity.3.3. Properties of the DFT: Periodicity.3. Correlation of Discrete-Time Signals: Crosscorrelation and Autocorrelation Sequences. Inversion of the Z-Transforms: The Inversion of the Z-Transform by Power Series Expansion.1.3.3. 10.P. Causality.6. Signals and Systems by Chi-Tsong Chen.2) of Textbook– I : The Discrete Fourier Transform: Its Properties and Applications: Frequency Domain Sampling: The Discrete Fourier Transform.1. Digital Signal Processing – Principles. Stability.3) of Textbook – 1. 7. Selected portions from Chapter 2 (2. 3.2. Classification of Discrete-Time Signals. Pole Location and Time- Domain Behavior for Causal Signals.2. PCBM4302 SIGNALS & SYSTEMS (3-0-0) Module – I (10 hours) Discrete-Time Signals and Systems: Discrete-Time Signals: Some Elementary Discrete-Time signals. by B.7) of Textbook – II The Continuous-Time Fourier Transform: Basic Concepts and Development of the Fourier Transform. Text Books: 1.3. System Properties: Homogeneity. Properties. 3. Manolakis. Lathi.2) of Textbook – I Properties of Continuous-Time Systems: Block Diagram and System Terminology.III (13 hours) The Z-Transform and Its Application to the Analysis of LTI Systems: The Z-Transform: The Direct Z-Transform.2.p.4. TMH 3. Oxford 4. Additional DFT Properties. Properties of the Continuous-Time Fourier Transform. 2. Solution of Difference Equations. Principles of Signal Processing and Linear Systems. 8. Calculation of the Fourier Series. 3. 3.P. 2.6. Selected portion from Chapter – 7 (7. TMH. The Inversion of the Z-Transform by Partial-Fraction Expansion. 2. Properties of the Z-Transform. 5. Stability of LTI Systems.4.1. 2. 7.6. The One-sided Z-Transform: Definition and Properties. 3.1.4) of Textbook – II Module – II (12 hours) The Continuous-Time Fourier Series: Basic Concepts and Development of the Fourier Series. Time Invariance. Selected portions from Chapter 3 (3. Rational Z-Transforms: Poles and Zeros.2. Analysis of Discrete-Time LTI Systems: Techniques. Multiplication of Two DFTs and Circular Convolution. 2. The Inverse Z-Transform. 2. by B. 3. Causal LTI Systems. Roberts.1.6) of Textbook – II Module. G. Signals and Systems . 2. The System Function of a Linear Time- Invariant System. 2. Discrete-Time Systems Described by Difference Equations.M. Lathi. 2.

Introduction to Formal Languages. Left and right linear grammars. PHI. class NP. Cook. Closure and decision properties of regular sets. 4. recursiveness of Ackermann and Turing computable functions. Chomsky and Griebach normal forms. Introduction to Automata Theory. Recursive and recursively enumerable sets. Ogden's lemma. Module – II 12 Hrs Context free grammars and pushdown automata. Introduction to Languages and the Theory of Computation: Martin. Mishra N. Parikh's theorem. Pumping lemma of regular sets. Primitive recursive functions. Church Turing hypothesis. Time complexity class P. Cengage Learning 2. Production rules and derivation of languages. Regular grammars. Parse trees. Cantor and Godel numbering. Turing computability . 2nd Edition. mu- recursive functions. closure properties of deterministic context free languages. Undecidability of Post correspondence problem.A. Pumping lemma. Universal Turing machine and undecidable problems. Kirthivasan.D Ullman.L. Theory of computer Science (Automata Language & computations) K. regular expressions and finite automata (deterministic and nondeterministic). Reference Books: 1. NP completeness. Introduction to Computer Theory: Daniel I. TMH. Kasami. Ackermann's function.E. Hopcroft and J. 3rd Edition. Module – III 14 Hrs Turing machines and variation of Turing machine model. Younger. Elements of Theory of Computation: Lewis. Pearson Education. 3. 3rd Ed. Willey India. Valid and invalid computations of Turing machines and some undecidable properties of context free language problems. 2. Minimization of finite automata. Text Books: 1. Type 0 languages. Rama R. Linear bounded automata and context sensitive languages. 3. PECS5304 THEORY OF COMPUTATION (3-0-0) Module – I 10 Hrs Alphabet. Automata Theory and Computation: K. Deterministic pushdown automata. Languages and Computation: J. languages and grammars. Introduction to the theory of computation: Michael Sipser. Chomsky hierarchy of languages.. Chandrashekhar. Ambiguity and properties of context free languages. PHI . Cohen. and Early's parsing algorithms. Pearson Education.

W. 2. data cleaning. in other scientific applications) Text Books: 1. outlier analysis Advanced techniques: web mining.J. spatial mining.I 12 Hours Overview: Data warehousing. Introduction to the data warehouse project. overview of the components. classification by neural networks. Mining frequent patterns.clustering high dimensional data. correlations (market basket analysis. Biological data analysis. Data preprocessing (data summarization. A categorization of major clustering methods(partitioning methods. data reduction. data discretization). the apriori algorithm. 2. classification by genetic algorithm Module .PEIT5302 DATA MINING & DATA WAREHOUSING (3-0-0) Module . telecommunication industry. Data Mining –a Tutorial based primer by R. Pearson Education. data warehouses and data marts. Willey India. Reference books: 1. emergence of standards. understanding data warehousing Architecture. mining various kinds of association rules.Geatz. trends In data warehousing.II 14 Hours Introduction to Data mining. web enabled data warehouse. Data Mining: Concepts and techniques: J. . The compelling need for data warehousing. intrusion detection. from data warehousing to data mining. Data Mining & Data Warehousing Using OLAP: Berson. from association mining to correlation analysis) Classification: classification by decision tree induction. the Building blocks of data warehouse. Data mining Functionalities.Camber. TMH. M. Data warehousing Fundamentals: Paulraj Ponniah. Elsevier. OLAP. Module .Roiger.Han and M. Data mining applications in (financial data Analysis.III 10 Hours Cluster Analysis: types of data in cluster analysis. metadata in the data warehouse. data integration and transformation. Data warehousing implementation. Rule based classification. temporal mining. retail industry. associations. hierarchical methods).

Determination of blood group by agglutination 10. To determine the coefficient of absorption/adsorption in packed bed columns. Northern blotting 8. Immunoelectrophoresis closed conduit using (a) Venturimeter. Western blotting 6. Rocket immuno-electrophoresis 5. Experiments on flow measuring devices . To separate the solute from one phase to another (aqueous to solvent) phase by liquid-liquid extraction. Southern blotting 5. 10. Study and verification of conservation of energy of a flowing liquid in a Bernoulli’s apparatus. 3. Kozeny-Karman equation. Purification of immunoglobulin from blood serum by column chromatography 9. PCBT7302 r-DNA Technology Lab (0-0-2) 1. Radial immunodiffusion technology 4. 5. 8. 9. Blake-Plummer Equation. 7. To Determine the Overall heat transfer coefficient of a concentric pipe heat exchanger based on the inside diameter of the tube. Experiments on Reynold’s Apparatus-Determination of flow regime and construction of friction factor against NRe. Determination of mixing time in stirred tank reactor. 2. 6. Gene cloning 9. Localization of specific antigen by immunocytochemistry . To calculate the heat loss in a lagged pipe made of various insulating materials. Immunoblotting 8. DNA profiling by RAPD 4. Determination of volumetric mass transfer coefficient (Kla) of gas-liquid system. Expression of cloned gene. Isolation of m-RNA 7. c-DNA synthesis by RT PCR PCBT7301 Immunotechnology lab(0-0-2) 1. 10. (b) Orifice meter (c) Rotameter. Amplification of DNA sample by PCR 3. Ouchterlony double diffusion technology 3. 4. Restriction digestion and Construction of restriction map 2. Preparation of blood film and identification of different leucocytes 2. PCBT7303 UPSTREAM PROCESS ENGINEERING LAB (0-0-2) 1. Determination of Pressure drop for flow through packed bed & verification of Ergun Equation. Dot ELISA and Sandwich ELISA 7.

Hill International Edition. Safety procedures. Bottling. Module – II: Waste Water Treatment: DO and BOD of Waste water treatment process.K. New Delhi. Product Safety. Hazardous waste and their generation. 2. 1997. Industrial Safety Management. Atmospheric dispersion. Irwin/ McGraw Hill International Edition. Text Book 1. Sincero PHI Publication 2. Soil chemistry. Water Treatment: water quality standards and parameters. primary and secondary treatment of waste water. air pollution meteorology. pretreatment. Reuse and recycling. 5. Environmental Engineering by Arcadio P.I. Extinguishing Fire. EU. Nitrogen cycle etc. Corrosive Substances. Environmental auditing. Solid Waste Management. Noise pollution. Colling. Reactor configurations and methane production. E. Environmental Science. Flue gas desulphurization. measurement and control. Type of Accidents. Reference 1. Advanced water treatment process. Masters & Wendell P. criteria pollutants. L. Acid deposition. L.. Chemical and Heat Burns. Davis and S. Air Pollution : Air pollution and pollutants. L. Fire Prevention – Detection. Hazardous Waste Management. 2004 4. Industrial Safety Management and Technology. Pharmaceutical industry. Man and Environment by Dash & Mishra 6. Module – III: Occupational Safety and Health Acts. Electrical Safety. D A – Prentice Hall. Environmental Engineering. Environmental Engineering by Prof B. non-criteria pollutants. Water treatment processes.. Activated sludge treatment: Anaerobic digestion. G. Safety Management. Food Chain. Pre-treatment of water. Petroleum Refinery. storage and transportation. Seven Seas Publication. Source classification and composition of MSW: Separation. 6th Semester HSSM3303 ENVIRONMENTAL ENGINEERING & SAFETY (3-0-0) Module – I: Ecological Concepts: Biotic components. Tolerance levels of environment factor.Noise standards. J. M. Gas Cylinders. Sincero & Gergoria A. Ela - PHI Publication. Prevention of Accidents involving Hazardous substances. Fugitive emissions. Oxygen cycle. 7.P. Curringham & Saigo. Kiely. Solid waste. .G. Cuttack 3. TMH. Environmental gradients. Conventional process.Safety Handling and Storage of Hazardous Materials. US and Indian Environmental Law. Inorganic waste treatment. Global climate change – greenhouse gases. Hazard Control Measures in integratednsteel industry. An Introduction to Environmental Engineering and Science by Gilbert M. Ground water. Chemistry in Environmental Engineering: Atmospheric chemistry. Water cycle. Ecosystem Process: Energy. Deshmukh. NOx removal. Human error and Hazard Analysis. Personal Protective Equipments. Waste Minimization Techniques.A. Principles of Environmental Engineering and Science. M. Industrial Air Emission Control. McGraw 3. Hazardous waste management. Masen. Transportation and treatment: Incinerators. Mohapatra. Tata McGraw Hill Publication. Hydro Carbons and Wastes.

EMBL and DDBJ. EMP. Sequence profile and HMM. Bernhard houbold . Wiley International Science. promoters. KEGG. target identification. Bioinformatics: Sequence and Genome Analysis. Current Topics in Computational Molecular Biology. Spring Harbor Press 2. Arthur Lesk. Drug design process for a known and unknown target.WILLEY-VCH press.Bioinformatics from genome to drug . Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. Multiple sequence alignment and dynamic programming. Tao Jiang. Zhang. Baxevanis AS and Ouellette BF. Basic algorithms for prediction of ORF. EST. Molecular mechanics and force fields. Mount DW. Prentice Hall Inc 5. CATH . 3. structural databases: SCOP. Module-III: Molecular modelling and drug design: Computational tools and Techniques: Homology modelling. Text Books: 1. EMBL.Retrieving microbial and viral genome information. splice sites. MetaCyc. MIT press. statistics of local alignment. Module-II: Sequence alignment and analysis: Fast Alignment methods: Genome Comparison and Database Searching. Michael Q. Docking methods. . Protein Data Bank(PDB). NDB. SNP. UTRs Sequence variation and molecular evolution :significance of Ka/Ks. PIR. molecular dynamics simulation. PCBT4304 BIOINFORMATICS (3-0-0) Module-I: Searching Biological Data From databases: Finding the information stored and its retrieval methods at NCBI. Drug design Process.Thomas Wiehe. CCSD. 2. Local and global alignment and application in determining gene and protein families.Introduction to computational biology : an evolutionary approach Blkhauser verlag press Reference: 1. Thomas lengauer. Bioinformatics computing. Metabolic pathways databases. Bryan Bergeron. Oxford University Press. Ying Xu. 4. drug like Property of a molecule. Basic idea about Molecular descriptors and QSAR analysis. Swiss Prot. Introduction to Bioinformatics. Pfam.

J. Application of Biocatalyst. Macmillan Publ. Biochemical Engineering and Biotechnology Handbook. Ltd.. Prescot and Dunn. analytical purpose and medical therapy. Biochemical Engineering Fundamentals. selection. The Nature Press.F. Bailey & Olis. Principle of Fermentation Technology . P. F. Isolation. continuous and feed batch fermentation. polysaccharides. genetically engineered strain and fermentation. Module-II: Commercial media and strain development: Media selection and development for industrial production. protein engineering. . A. Elsevier 2. Text Books 1. strain improvement: induced mutation. isomarization and rearrengement. Group transfer redox. Industrial Microbilogy. enzymes. Application of enzymes in industry. characterization of microorganisms. Stanbury. Module-III: Stability of enzyme: Enzyme stabilization by selection and genetic engineering. Large scale production: submerged. development inocula. Elimination. 4. 3. MGH. chemical modification. solvents. solid and semi-solid fermentation. Atkinson. over producing decontrolled mutants. Microbiological processes for production of organic acids. Microbial growth and product formation kinetics in batch. Whitaker and S. Reaction environment rebuilding. PCBT4307 INDUSTRIAL MICROBIOLOGY & ENZYME TECHNOLOGY (3-1-0) Module-I: Microbial Processes and fermentation technology: Introduction to fermentation technology. Hall. stock culture. C-C bond cleavage. intramolecular cross linking and immobilization. pigments and aroma. B and Marituna. lipids. antibiotics.

Screening and selection of somatic hybrid. 3. H S Chawla. Electroporation. Application of genetic transformation: promoter tagging. herbicide resistance. etc.. Production of secondary metabolites through tissue culture. International. Tissue culure media. Single cell culture. disease resistance. Callus culture. Virus) and Direct transformation (Gene gun. composition and plant growth regulators. Plant Biotechnology. terminator seed technology. Recent advances in Plant Biotechnology. Biotransformation with case studies. Products of genetic transformation: Case studies for golden rice. Plant Biotechnology. Bt cotton and Flavr Savr tomato. .preparation. Plant Biotechnology. Protoplast technology: Isolation and culture of protoplast. Oxford Univ. A Kumar and SK Sopory. Micropropagation: Organogenesis. Initiation and establishment of culture: Explant preparation. A Slater et al. activation tagging. Microspore culture. molecular farming. S. Embryo rescue. PCBT4305 PLANT BIOTECHNOLOGY (3-0-0) Module-I: Plant Tissue Culture concepts and Methods Concept of totipotency and plasticity of plant cell. Oxford University Press. I. insect resistance. Microinjection. Module-III: Plant genetic Engineering and its applications Concept of genetic transformation: Vector based (Agrobacterium. Bioreactor based production of secondary metabolites and its kinetic studies. Somatic hybridization.). Artificial seed. isolation and purification of secondary metabolites. Module-II: Biotechnology of secondary metabolites Secondary metabolites of plant origin and its type. Somatic embryogenesis. 2. 4.K. Suspension culture. Text Books: 1. K G Ramawat. Factors affecting the production and its optimization. Press. Chand & Co.

Bioseparations Engineering. Cell disruption: Physical methods (osmotic shock. Ladisch. Liquid Electrophoresis. USA (October 31. continuous. precipitation. membrane geometry and ultrafiltration module configuration. gel-filtration. Paul W.R. aqueous two-phase extraction. Roger G. 2002) . Ion. liquid shear).roducts polishing : Crystallization and drying. Rudge. centrifugation (batch. Separation of cells and other insolubles from fermented broth. grinding with abrasives. Scott R.PCBT4306 DOWNSTREAM PROCESS ENGINEERING (3-0-0) Module -I: Introduction. Oxford University Press. 4. Enzymatic methods Module -II: Ultra-filtration: Semipermeable membranes. Other bioseparation techniques like Dialysis. Kennedy and Cabral. adsorption. basket). and Demetri Petrides. Heinemann. M. Todd. Filtration and microfiltration. Bioseparations Science and Engineering. Recovery processes for biological materials. Module-III: Separation of soluble bio-products: Liquid-liquid extraction. detergents). Product Recovery in Bioprocess Technology. Harrison. high pressure / performance liquid chromatography (HPLC). solid shear. 3. Text Books: 1. An overview of bioseparation. Chemical methods (alkali. Wiley Interscience 2001 2. hydrophobic chromatography. affinity. Chromatography: Adsorption chromatography. Reverse phase (RP) and thin layer chromatography (TLC). Butterworth Publication.

Lemons. Springer 2009 . aluminum oxides. Park J and R. 2. Ti-based alloys. Biomaterials for ophthalmology. Implants materials: metallic implant materials. Hoffman Frederick J. thermal. Biomaterials: An Introduction. ceramic implant materials. Text Books 1. mechanisms and applications. Buddy D. pharmaceutical polymers. Biomaterials: its foreign body response in a body. Bhatt SV. Lakes R S. electrical and surface) of biomaterials. Structure and properties (mechanical. orthopaedic and dental implants. kinetics. Narosa publishing house 3. Polymers for drug delivery: types of polymer. Biomaterials Science. Biomaterial. self- assembling peptides. Evaluation of biomaterials. Second Edition: Wiley Science 2004. S. PEBT5303 BIOMATERIALS (3-0-0) Module-I: Introduction to biomaterials. stainless steels. interaction with biomaterials and adhesion. Biologically functional biomaterials. optical. Module. Synthetic polymer. physicochemical properties of polymers and relationship with structure. Ratner Allan S. Biological response to implants. cardiovascular implants. Biopolymer Module-II Novel Biomaterials and uses in engineering and tissue engineering: Hydrogels. Schoen Jack E. 2D and 3D matrices (scaffolds) of biomaterials for tissue engineering. hydroxyapatite glass ceramics carbons. Soft tissue and hard tissue replacement. Testing and clearance of biomaterials. Biological interface. Polymeric implant. Co- based alloys. properties.III: Biocompatibility and blood compatibility.

Module-II: Introductionto molecular dynamics and simulations. De novo Ligand design. energy calculations. biological activities. Jonathan Good man.the alignment. physicochemical parameter and molecular descriptors. molecular modelling in drug discovery. Monte-carlo simulation of biomolecules and bio-polymers. linear and nonlinear modeled equations. Hans Pieter. Molecular mechanisms. Molecular size versus accuracy. Principles and applications of modeling. Bond stretch. Sources of data. side chain placement and refinement. Cambridge Press . References: 1. semi-empirical and density functional theory calculations. Angle bending. selecting variable regions. molecular similarity and disimilarity searching. Prentice Hall. A R Leach. Dynamics with continuous potentials. 3D data base searching and virtual screening. nucleic acid/ protein interactions. Chemical Applications of Molecular Modelling. Approximate molecular orbital theories. Electrostatic interaction. PEBT5302 Molecular Modeling and Drug Designing (3-0-0) Module-I: Introduction to Molecular Modelling and its applications Biomolecular modeling problems: protein folding. validation of protein models –Ramchandran plot. torsional terms. protein misfolding. Free energies and solvation. ab initio. Heltje & Gerd Folkens. Comparative modeling of protein: by homology. Conformation searching and systematic search. threading and ab initio modeling. Molecular Dynamics using simple models. Structure based drug designing: 3D pharmacophores. electrostatic and non-electrostatic contribution to free energies. combinatorial libraries – generation and utility. VCH. Molecular Modelling. Basic concepts of quantum mechanics.Van der waals interactions. Constant temperature and constant dynamics. construction of frame work. 2. molecular docking. Text Book: 1. and RNA folding. Module-III: Analog based drug designing : Introduction to QSAR. lead module. Miscellaneous interactions.

Kinetic studies and determination of Km and Vmax 2. Module-III Microfabricated devices to study directed cell migration. Separation of proteins and DNA using affinity chromatography Enzyme technology laboratory: 1. Micro. Scanning probe techniques (SPM). Protein fractionation using precipitation/solvent extraction techniques. Module-II Structural and functional principles of nanobiotechnology. PCBT7306 DOWNSTREAM PROCESS ENGG. Polymeric nanocontainers for drug delivery. nanoparticles and nanowires. & ENZYME TECH LAB (0-0-3) Downstream Processing: 1. Ltd.and nano -fabrication.g Alkalne phosphatase / Amylase / Invertase / dehydrogenases) using whole cells and/ or purified enzyme. Enzyme assay techniques (e. Effect of inhibitors on enzyme kinetics 3. Molecular nanotechnology. Applications and Perspectives. Protein and DNA based nanostructures. Exploration of biology and biological systems. Microbial synthesis of nanoparticles. Nanobiotechnology: Concepts. Cell disruption by homogenizers. etc.) 4. Nano-particles and imaging applications. 4. Cell nano structure interaction. Micromachining: MEMS NEMS. Carbon nanotubes. sonication and French press. PEBT5301 NANOBIOTECHNOLOGY (3-0-0) Module-I Introduction to Nanosciences and Nanotechnologies. 2004 2. 2. osmotic shock. Immobilization of cells and enzymes using different matrices (PVA. . 3. Application of immobilized cells and enzymes in batch and continuous stirred tank reactors. Niemeyer C M and Mirkin C A. Harvesting cells using filtration or centrifugation techniques. Wiley VCH. drug and gene delivery. BioMEMS. alginate. Text Book: 1. Lab-on-a-chip devices and their potential in nanobiotechnology. magnetosomes. PHI learning Pvt. identification of extracellular products (enzyme / poly saccharide / some other traceable element) from fermentation broth or shake-flask culture broth. Protein fractionation using chromatography (gel filtration and ion-exchange) 5. Nanoscience and Nanotechnology. Nanoanalysis and nanobiosensors. biology at the nano-interface. 5. Chattopadhyaya KK and Banerjee AN. Biotransformation reaction using whole cell and/or enzyme(s). bacteriorhodopsin.

Retrieving Human genome data. Conversion of 2D structure to 3D structure. ndb. 7. Media preparation. SNP databases to understand genetic and metabolic disorders. Analysis of alcohol or citric acid by spectrophotometric method and gravimetric method. Gene and promoter prediction for Prokaryotes and eukaryotes (comparative analysis by using different tools: at least 3) 5. Prediction of Tertiary structure of proteins and Validation of model protein structure: Energy minimization. Anther culture of Datura 5. Production and optimization microbial metabolites (Ethanol or Citric acid) and study of fermentation kinetics 4. sterilization. (At least 2 each) 2. Learning about molecule visualisation software like Rasmol. verify 3D. Primary Structural databases: pdb. OMIM. Molecular docking and analysis of receptor with ligand ************** . Making Phylogenetic tree of given sequences by using ClustalW and PHYLIP. PCBT7305 PLANT BIOTECHNOLOGY AND INDUSTRIAL MICROBIOLOGY LAB (0-0-3) Plant Biotechnology 1. Procheck. 9. Prosa II. Agrobacterium mediated transformation (Co-cultivation & GUS expression)- Industrial Microbiology 1. FSSP. Submerged fermentation in single-culture. 3. Somatic embryogenesis in carrot and encapsulation somatic embryo or PLBs 4. explant preparation and establishment of meristem culture 2. 5. Establishment of suspension culture 6. Pymol etc. CATH & SCOP. PCBT7304 BIOINFORMATICS LAB (0-0-3) 1. ERRAT etc. 10. 6. repeats. Prediction of secondary structures of proteins: at least 3 methods 8. Fermenter operation and study of product formation by batch culture. Molecule drawing. 4. Study of organogenesis and multiple shoot generation 3. Homologous sequences etc. Mining genomic data to identify genomic features: codon usage. ccsd and Derived databases of structures: DSSP. co-culture condition 3. Preparation of starter culture of yeast in grape juice 2.

ORISSA BIOTECHNOLOGY 7th Semester 8th Semester Theory Subject Credit Credit Theory Subject Credit Credit Hrs Hrs PCBT4401 Medical & Pharmaceutical 3-0-0 3 HSSM3403 Marketing Management 3-0-0 3 Biotechnology PCBT4403 Food biotechnology 3-0-0 3 PCBT4402 Bioreactor Design & analysis 3-0-0 3 Professional Elective 3-0-0 3 PCBT4404 IPR in biotechnology. & Bioethics Professional Elective (Any One) 3-0-0 3 PEBT5402 Animal & stem cell technology Free Electives-III 3-0-0 3 PEBT5403 Genomics & proteomics PECS5410 Algorithms in Bioinformatics PECE5404 Process Simulation & Modeling Professional Elective (Any One) 3-0-0 3 PEBT5404 Environmental Biotechnology PEBT5405 Biosensor and Diagnostics Free Electives-II (Any One) 3-0-0 3 PECS5401 Artificial Intelligence PEEC5416 Biomedical Instrumentation Total 12 Total 18 Practical PCBT7401 Minor Project 0-0-2 2 PCBT7403 Major Project 0-0-6 6 PCBT7402 Industrial Internship Seminar 0-0-2 2 Entrepreneurship project 0-0-2 2 PCBT7404 PCBT7405 Comprehensive Viva 0-0-3 3 Total Total 4 11 22 23 . BIJU PATNAIK UNIVERSITY OF TECHNOLOGY .Biosafety 3-0-0 3 PEBT5401 Protein Engineering.

Genetic diseases and DNA based diagnoses. Toxicogenomics Module III Proteomics in Drug Development Role of Proteomics in Drug Development. Concepts in Biotechnology. Balasubramanian. drug targeting Module-II Disease Diagnosis and Therapy ELISA and hybridoma technology. Use of enzymes in clinical diagnosis. Development of antibody based protein array for diagnosis Text Books 1. MEDICAL AND PHARMACEUTICAL BIOTECHNOLOGY (3-0-0) Module-I Drug Development in Pharmaceutical Process Production of pharmaceuticals by genetically engineered cells (hormones.A. interferon). Techniques for development of new generation antibiotics. Green and Jayaraman(ed). 1996 2. London 3. Diagnosis of disease by Proteomics. Bryce. Protein engineering. Diagnostic kit development for microanalysis. Use of biosensors for rapid clinical analysis. Monoclonal antibodies: applications in clinical oncology. Chapman and Hall Medical. drug design.(ed). Text book of industrial pharmacy by S R Hiremath. Epenetos A. Orient Black Swan publication . University Press. DNA vaccine. Dharmalingam. Microbial transformation for production of important pharmaceuticals (steroids and semi- synthetic antibiotics). Gene Therapy. Separation and identification techniques for protein analysis.

. Reactor stability. O. models of non-ideal reactors – plug flow reactor for microbial processes. membrance reactor. valves.I: Principles and concepts Recapitulation of the principles of Kinetics for chemical and Bio-chemical Reactions. piping and valves for biotechnology. Enzyme catalyzed reactions in CSTRs. B. Growth and product formation by recombinant cells. An introduction to chemical engineering design. residence time distribution. adiabatic and programmed reactors. Nelson. online sensors for cell properties. air lift fermenter etc. D’Elia. rheology.Flow Tubular reactor. 2.III: Bioreactor Design Design considerations: oxygen transfer. Wiley Eastern Ltd. off-line analytical methods. stirred tank/mixed reactors. Biochemical Engg. welds. London. Atkinson. finish. Scale up and scale down concepts. Pergamon Press. Fudamentals. . Multiphase bioreactors – packed bed with immobilized enzymes or microbial cells. heat transfer. agitation system materials. continuous stirred rank reactors (CSTR). Fundamentals of homogeneous reactions for batch / semi-batch. Levenspiel.. Module.1990 3.. plug low reactor (PFR). Mechanical fittings in a bioreactor: vessel. Analysis of Non-ideal Reactor Analysis: Concept of ideal and non-ideal reactor. Bioprocess engineering: Systems and equipment. BIOREACTOR DESIGN AND ANALYSIS (3-0-0) Module. Chemical Reaction Engineering. 4. Bioprocess control and computer coupled bioreactors. Instrumentation and control of bioprocesses: Physical and chemical sensors. Sinnott.. Ideal Plug. Lydersen. Biosensors. Gas liquid reactors. three – phase fuidized bed trickling bed reactor. Text Books 1. MGH. pion Ltd.. CSTR reactors with Recycle and Wall growth. special requirements of utilities and cleaning of production plants. Mass transfer in biochemical processes. Module.II: Bioreactor Analysis Analysis of ideal bioreactors: Fed-Batch reactors. Unconventional bioreactors: Hollow fiber reactor. fluidized bed reactor bubble column. Bioreactor design calculation.1974. Design and analysis of the above reactor systems. mixing. Richardson. Coulson. Bailey & Olis.Biological Reactors. perfusion reactor for animal and plant cell culture.

Data mining. Stability to changes in parameters as pH. Hydrodynamic properties–viscosity. hydrogen bonding and weakly polar interactions. hydrogen-deuterium exchange. 1st Edition. 5. .. Ramachandran map. Protein function. Mueller and Arndt.. Entropy – enthalpy compensation. 3. Module-II Methods of measuring the stability of a protein. Edited by T E Creighton. Spectroscopic properties. Oxford university press. A practical approach. applications. Protein and enzyme engineering case studies for its stability. Protein engineering protocols. Edited by T E Creighton. ORD. Oxford press. electrostatic. . Protein engineering – definition. temperature and amino acid sequence. Features or characteristics of proteins that can be engineered. Spectroscopic methods to study physicochemical properties of proteins: UV. Vol 7. 6 L. Cleland and Craik. Brief introduction to NMR spectroscopy. CD.affinity and specificity. Springer Netherlands. Harwood Academic Publisher. 4. 2nd Edition. Protein Engineering for industrial biotechnology. PROTEIN ENGINEERING (3-0-0) Module. Protein Engineering. Mechanism of stabilization of proteins from psychrophiles and thermophiles vis-à-vis those from mesophiles. Mass spectroscopy and X-ray crystallography and their application in protein engineering. Computational approaches to protein engineering: sequence and 3D structure analysis. etc. Guided protein recombination. Text Books /References: 1. Alberghina. Fluorescence. Protein structure: A practical approach. Principles and Practice. aggregation propensities. Module shuffling. A practical approach. Lipase and Lysozyme. Oxford university press. Directed evolution like site directed mutagenesis.Protease. specifity and affinity. Humana Press.I Overview of protein structure and its hierarchical architecture. hydrophobic effects. Forces stabilizing proteins – Van der waals. Edited by T E Creighton. Module-III Experimental methods of protein engineering: Rational designing. 2. Protein function.. 2nd Edition. etc.

Bryce. 1989. Measurement of viability and cytotoxicity. Cell type and characterization.Concepts in Biotechnology. animal cloning Text Books: 1. Organ culture technology. 3rd Edition. culture technology. Application of animal cell culture. Module III: Cell transformation. Green and Jayaraman (Eds. Hybridoma technology. Immunology. Transfection of animal cells. ANIMAL AND STEM CELL TECHNOLOGY (3-0-0) Module-I: History of animal cell culture and development. Dharmalingam. Brief discussion on the chemical. perfusion and hollow fibre reactor.. origin of animal cell line. Marker gene characterization. Balasubramanian. Culture media and growth conditions. Oxford.E. 5. & Wilson J. Wiley-Liss publication 2. Equipments and materials for animal cell. 1996. Weissman I. Development of cell line by enzymatic disaggregation. Cell culture in continuous. Hood L.B. Biotol Series – Butterworth and Heineman. maintenance and characterization of different cell lines. stem cell cultures. measuring parameters of growth. Ian Freshney. Wood W. (Eds) Animal Cell culture Techniques Springer Publication 3. Micro-carrier attached growth. Culture of Animal Cells. 4. S Chand publication . Biology and characterization of the cultured cells. Module-II: Cell growth characteristics and kinetics. embryonic stem cells and their applications. R. University Press. Development of primary culture. Future tissue engineering. 1992 6.Benjamin Cummings. physical and metabolic functions of different constituents of culture medium.. A Text Book of Biotechnology R C Dubey. Mass transfer in mammalian cell culture. Martin Clynes.).H.

Viva publications . RAPD. structural proteomics. Pennington SR & Dunn MJ. Yeast two hybrid and three hybrid system. Brown TA. Blackwell. plants and animals. GENOMICS AND PROTEOMICS (3-0-0) Module-I: Genome organization in prokaryotes and eukaryotes. 2-D electrophoresis of proteins. Module-II: Genome sequencing projects. Genome sequencing strategies. Voet JG & Pratt CW. Texts / References Book: 1. Garland Science 3. Proteomics. Accessing and retrieving genome project information from web. Voet D. Functional genomics and Comparative genomics. SAGE and Differential display proteomics. Primrose S & Twyman R. amino- acid composition. Genome analysis using 16S rRNA typing/ sequencing. Concept of TILLING.Microbes. 2nd Edition. Peptide fingerprinting. DNA Chip technology. Wiley 2. High throughput screening in genome for drug discovery-identification of gene targets. Genomes. ASM Press 6. Discovering Genomics. Pharmaco-genomics and drug development. isoelectrofocusing. 2nd Edition. SSR. ESTs and SNPs. Concept of minimal cell genome. Glick BR & Pasternak JJ. 3rd Edition. MALDI-TOF. Proteomics and Bioinformatics. Molecular Biotechnology. 3rd Edition. 5. Campbell AM & Heyer LJ. Principles of Gene Manipulation and Genomics. Protein analysis (includes measurement of concentration. Recognition of coding and non- coding sequences and gene annotation. Tools for genome analysis-Linkage analysis including pedigree. LC/MS-MS for identification of proteins and modified proteins. Protein micro array. Proteomics and Drug delivery. Protein- protein interactions. principles and methodology. Structural genomics. STS). Reverse genetics. Benjamin Cummings 4. Module-III: Introduction to proteome. N-terminal sequencing). Genetic mapping using molecular markers (RFLP. Microscale solution. Physical mapping of the genome. Fundamentals of Biochemistry.

Module-III Applications of Biosensors: Clinical Chemistry & diagnostics. Biomicroelectronics and Nano- biotechnology. Nitrate and phosphate removal. In situ and ex situ remediation strategies. Metabolic pathways for biodegradation of hydrocarbon compounds and other organic pollutants. 2005 BIOSENSOR AND DIAGNOSTICS (3-0-0) Module-I Introduction to biosensors. Molecular Biology and Biotechnology. Commercial Biosensor. Alan Scragg. Phytoremediation. Text Books 1. Ramsay G. biomarker and biosensor technology. definitions and facts. Turner APF et al. Electrochemical. Immunosensors & In-vivo Biosensors. Overview of microbial transformations. bioethahnol production. Module-III: Clean technologies: biofertilizers. Oxford University Press. Piezoelectric biosensors. Environment and pollution monitoring. . Biotechnology of sewage treatment. John Willey & Son 4. biohydrogen.principles and applications. Blum LJ & Coulet PR. Biochemical. Rittmann B and McCarty P. environmental genomics.. Biofuels: biogas. Bioprospecting. Principle. Principles of bioremediation of organic and inorganic contaminants. Thermistor based biosensor. Medicine and health care. Immobilization as key to biosensor construction. Ethical issues in environmental biotechnology. Food preservation & contamination. Components of Biosensor. Biotechnology of fossil fuels: desulfurization of coal. biopesticides. Environmental biotechnology. mechanisms. Walker JM & Rapley R. ENVIRONMENTAL BIOTECHNOLOGY (3-0-0) Module-I: Introduction to environmental biotechnology. Text Books: 1.Biological. Whole cell biosensor. microbial polymer production and bio plastic technology. Biosensors fundamentals & Applications. Module-II: Metagenomics. Conductimetric biosensor. Environmental Biotechnology: Principles and Applications Mc Graw Hill 2001 2. and. construction and applications of Redox mediated (Amperometric & Potentiometric) biosensor. Agriculture and food production. Bioaffinity principle and biosensor. Veterinary. Environmental monitoring: bioreporter. Oxford University Press 2. Field Effect transitor systems (FETs) based biosensor. Calorimetric biosensor & Optoelectric biosensors. oil shales. microbial enhanced oil recovery (MEOR). Marcel & Decker Inc. Microbial interaction with metals and radionuclides. Electronic. 3. Biotechnology of mineral processing. Biosensor Principles & Applications. Panima publishers. Module-II Biosensor diversification.

Artificial Intelligence. Discourse and Pragmatic Processing.Problem Spaces. Iterative Deepening. Cengage Learning. Formal Learning Theory. Logic Programming. Spell Checking. Adding Alpha-beta Cutoffs.Using Rules: Procedural Versus Declarative Knowledge. Augmenting a Problem-solver. Module 3 Learning: Rote Learning. Computable Functions and Predicates. Explanation.. Implementation Issues. Text Book: 1. Hierarchical PlanningOther Planning Techniques. Goal Stack Planning.2009 References: 1. Breadth-first Search. Learning from Examples: Induction. Kevin Knight. Understanding as Constraint Satisfaction. Analogy. Best-first Search.2011  .. Issues in the Design of Search Programs. Learning by Taking Advice. 3rd ed. Approaches to Knowledge Representation. Hill Climbing. Semantic Analysis. Planning: The Blocks World. S Kaushik. & Shivashankar B Nair. Production Systems. Problem Characteristics. 1st ed. Statistical Natural Language Processing. Components of a Planning System. Means-ends Analysis. Using Predicate Logic: Representing Simple Facts in Logic.Knowledge Representation: Representations and Mappings. Syntactic Processing. and Search: Defining the Problem as a State Space Search. Resolution. Production System Characteristics. Constraint Satisfaction.Weak and Strong Slot-and-Filler Structures: Semantic Nets. Knowledge Acquisition. Expert Systems: Representing and Using Domain Knowledge. Conceptual DependencyScripts. ARTIFICIAL INTELLIGENCE Module 1 What is Artificial Intelligence? AI Technique. Explanation-based Learning. PHI. Expert System Shells. Level of the Model. Depth-first Search.Heuristic Search Techniques: Generate-and-Test. Discovery. Problem Reduction. Nonlinear Planning Using Constraint Posting. Representing Instance and ISA Relationships.Understanding: What is Understanding. What Makes Understanding Hard?. CYC. Forward Versus Backward Reasoning. Logics for Nonmonotonic Reasoning. Dan W Patterson. Module 2 Game Playing: The Minimax Search Procedure.Symbolic Reasoning Under Uncertainty: Introduction to Nonmonotonic Reasoning.2010 2. Natural Deduction. McGraw Hill.Natural Language Processing: Introduction. Elaine Rich. Matching. Learning in Problem-solving. Neural Net Learning and Genetic Learning. Introduction to Artificial Intelligence & Expert Systems. Artificial Intelligence. Control Knowledge. Frames.

Motion Artifacts Module – II (13 Hours) Physiological Transducers: Introduction to Physiological Transducers. Ultrasonic Blood Flow meter. Weibell. Electrodes for ECG. General Considerations for Signal Conditioners. Skin Contact Impedance.S. Pfeiffer. Depolarization. Carr. Potentiometric Recorders. Blood Pressure Measurement. PC Based Medical Instrumentation Systems. Biosensors.Khandpur. John M. Phonocardiograph. Biomedical Instrumentation and Measurements-2nd Edition by Leslie Cromwell.18) 2. Fred J. Pearson Education 2007 . Transducers for Body Temperature Measurement. Electroencephalograph (EEG). Microelectrodes. Laser-Doppler Blood Flow meter Patient Safety: Electric Shock Hazards. Leakage Currents. Resting Potential Recording Electrodes – Ag-AgCl Electrodes. Classification of Transducers. Erich A. Biomedical Signal Analysis Techniques. Electromayograph (EMG) Module – III (14 Hours) Patient Monitoring Systems: System Concepts. General Constraints & Regulations of Medical Devices Biomedical Signals & Electrodes: Origin of Bioelectric Signals-Repolarization. Writing Systems: Direct Writing Recorders. Signal Processing Techniques. PHI learning Pvt Ltd 2nd Edition Reference Books: 1. Safety Codes for Biomedical Equipment Text Books: 1. Brown. Measurement of Heart Rate. EMG. Hand Book of Biomedical Instrumentation-2nd Edition by R. Measurement of Respiration Rate Blood Flow meters: Electromagnetic Blood Flow meter. Intelligent Medical Instrumentation Systems. Tata McGraw Hill 2003 (Chapters 1-6. Basic Medical Instrumentation System. Smart Sensors Biomedical Recording Systems: Basic Recording Systems.11. BIOMEDICAL INSTRUMENTATION Module – I (10 Hours) Fundamentals of Biomedical Instrumentation: Sources of Biomedical Signals. Pressure Transducers. Inkjet Recorder. Digital Recorders Biomedical Recorders: Electrocardiograph (ECG). EEG. Introduction to Biomedical Equipment Technology-4th Edition by Joseph J. NMR Blood Flow meter.

Trends in Marketing: Green Marketing. Himalaya Publishing House. Packaging and Labeling.Concept of IMC. Supply Chain Management (Basic only). Saxena. Global Market Research. Targeting and Positioning: Definition. Qualitative tools : Buying Intention Survey. Module -I (10 hours) Marketing Management: Concept. Walker . the marketing communication process. Module . Pricing method and strategies. elements of promotion mix. 2010/e. New Product Development Process. Kotler. special Indian edition. Positioning a Brand. Rural Marketing and Service Marketing (concepts only) Books: Text Book: 1. Promotion Mix. 4/e. ‘Marketing’ Tata McGraw Hill. manufacturing and selling product/ service packages keeping competitive market. “Marketing Management” Tata McGraw Hill. Marketing Planning : Exploring Opportunity. 3.Stanton and Pandit. Branding Strategy. 2. Forecasting Tools: Short term tools: Moving average and Exponential smoothing methods. Identifying and analyzing competitors. Market Demand Forecasting: Key Terms. Consumer Behavior: Factors influencing consumer behavior. E-marketing. Bases of segmenting consumer and Industrial markets. Brand Equity. Grewal. Karunakaran “Marketing Management”. Physical Distribution. Marketing. Marketing Environment: Elements of micro and macro environment Competition Analysis: Factors contributing to competition. Pearson Education. Marketing Planning Process. Customer Relationship Management. Direct marketing. Product Planning : Product Life Cycle. Module. Reference 1. Planned Obsolescence. Integrated Marketing Communication(IMC). The Internet and World Wide Web based Information collection and processing. Target Market strategies: Market Positioning. Data Warehouses and Data Mining. Channels of Distributions: Types of intermediaries. customers and cost in view. . Process. Etzel . Long-term forecasting Tools: Time series analysis. Tata McGraw Hill. 8th Semester MARKETING MANAGEMENT (3-0-0) Objective of the Course: The course aims at introducing the basic concepts of marketing to the undergraduate students in engineering. “Marketing Management”. The learning shall help the students in better designing. Database. Product –market selection. Levy. Designing Distribution Channels. Econometrics methods. porter’s five forces model. Functions and relevance in the current context. 14/e.III (10 hours) Pricing Decision: Objectives and Factors influencing pricing. 2. Product-mix and Product Line. channel levels.II (10 hours) Market Segmentation. Sales Force Opinion and Delphi Techniques. consumer decision process. Organizational buying behavior. Market Research and Information Systems: Research Process. 13/e. Keller. functions of distribution channels.Koshy and Jha.

mushroom. flavour. CBS publishers 5. Module II: Technology for improved process Enzyme in bakery. fungal toxins. Food Microbiology 3. genetically modified food Module III Food spoilage and control Spoilage of food. 1987 2. Food preservatives and additives. Aca. CBS publishers. Microbiology of water. ultrafiltration.Reed. Press . R. fermented cereal products. Food additives colour. Text Books 1.P. enzymes in beverage production. meat. sterilization. vitamins. Introduction to food engineering. 1987 4. Headman. irradiation etc.R. enzymes in sugar syrup. Protease in cheese making. pesticide and herbicide contamination. probotics/ prebiotics in food products. heavy metal. Singh and D. Microbial safety of food products. Modern Food Microbilogy. Technology – canning. oriental foods. Utilization of food waste for production of value added products. Pickling and alcoholic beverages. major ingredients present in different product. Jay. Fermentative production of food. milk. Post-harvest technology for food preservation. Enzymes in fat/oil industries. Teachnology of food preservation. G. CBS Publishers. Desrosier. Prescott and Dunn’s Microbiology. Frazier. FOOD BIOTECHNOLOGY (3-0-0) Module I: Food quality and Production technology Analysis of food. dehydration. Genetically manipulated crop based food. Chemical safety of food products. vegetables. Single cell protein.

Ethics in clinical trials and GCP. Case studies and examples-Rice. International framework for the protection of IP.Genetic testing and screening. Overview of National Regulations and relevant International Agreements including Cartagena Protocol. IPR IN BIOTECHNOLOGY. Definition of GMOs & LMOs. Concept of Bioethics. Wisdom educational services 2. Text Book 1. Prior art and Stae of art. Neem etc. for GMO applications in food and agriculture.meaning. Module-III: Introduction to Biosafety regulations. WIPO and TRIPS.novelty. Biosafety Levels of Specific Microorganisms. Traditional Knowledge. scope. Trademarks. remedies. Role of a Country Patent Office. Environmental release of GMOs. Intellectual property rights and its types-Patents. RCGM. Process patent vs product patent. Geographical Indications. GEAC etc. Ethics in human cloning-a case study. . litigation. Analysis and report formation. Searching International Databases. Patent databases. Recommended Biosafety Levels for Infectious Agents and Infected Animals. Biosafety guidelines . BIOSAFETY & BIOETHICS (3-0-0) Module-I: Concept of property. Protection of new GMOs. IK International Pvt. WIPO Treaties. WTO. Sateesh MK. Industrial Design. Ltd. Copyright & Related Rights. Bioethics. Precautions before patenting-disclosure/non-disclosure. Filing of a patent application. Public concerns on Human genome research and transgenics. Roles of Institutional Biosafety Committee. inventive step. Introduction to History of GATT. duties and their correlation. International patenting- requirement. IPs of relevance to Biotechnology and few Case Studies. Budapest Treaty. rights. Indian Patent Act 1970 and Recent Amendments. PCT and Implications. IP as a factor in R&D. Stanley SA. Module-II: Basic requirement of a patentable invention. Primary Containment for Biohazards and Biosafety Levels. ELSI & Human genome projects. Patent infringement. Procedure for filing a patent. Bioethics and Biosafety.Government of India.

Exhaustive Search: Restriction Mapping. Dynamic Programming Algorithms: The Power of DNA Sequence Comparison. Finding a Median String. DNA Arrays as an Alternative Sequencing Technique. Similarity-Based Approaches to Gene Prediction. Sorting by Reversals. Notations. Pro le HMM Alignment. Suf x Trees. Divide-and-Conquer Algorithms: Divide-and-Conquer Approach to Sorting. Biological Algorithms versus Computer Algorithms. The Motif Finding Problem. Global Sequence Alignment. 2004. Structure of DNA. An Introduction to Bioinformatics Algorithms. Evolutionary Trees. Statistical Approaches to Gene Prediction. Pevzner. Text Book: 1. Longest Common Subsequences. Tractable versus Intractable Problems. Approximate Pattern Matching. Bioinformatics Algorithms: Techniques and Applications Wiley. DNA Sequencing. Algorithms and Complexity: Biological Algorithms versus Computer Algorithms. SBH as an Eulerian Path Problem. Protein Identi cation via Database Search. Molecular Biology Primer: Genes. SBH as a Hamiltonian Path Problem. The Fair Bet Casino and Hidden Markov Models. Module 2 Greedy Algorithms: Genome Rearrangements. Alexander Zelikovsky. Local Sequence Alignment. The Change Problem Revisited. Heuristic Similarity Search Algorithms. Ion Mandoiu. Clustering and Corrupted Cliques. ALGORITHMS IN BIOINFORMATICS Module 1 Introduction. Clustering and Trees: Gene Expression Analysis. Random Projections. Character-Based Tree Reconstruction. Evolutionary Trees and Hierarchical Clustering. Protein Sequencing and Identi cation. Finding Motifs. Fragment Assembly in DNA Sequencing. Biological Algorithms versus Computer Algorithms. CRC Press (Taylor & Francis Group). "Algorithms in Bioinformatics: A Practical Introduction". The Peptide Sequencing Problem. Spectrum Graphs. Keyword Trees. Pro les. Multiple Alignment. 2008. Constructing Alignments in Subquadratic Time. Neil C. Module 3 Combinatorial Pattern Matching: Repeat Finding. Shortest Superstring Problem. Search Trees. Space-Ef cient Sequence Alignment. Hidden Markov Models: CG-Islands and the “Fair Bet Casino”. Proteins. Alignment with Gap Penalties. Algorithm Design Techniques. References: 1. MIT Press. Approximation Algorithms. Hierarchical Clustering . Breakpoints: A Different Face of Greed. Spectral Alignment. Exact Pattern Matching. Scoring Alignments. Spliced Alignment. Sequencing by Hybridization. 2009. Wing-Kin Sung. A Greedy Approach to Motif Finding. Block Alignment and the Four-Russians Speedup. Impractical Restriction Mapping Algorithms. . BLAST: Comparing a Sequence against a Database. Molecules. Distance-Based Tree Reconstruction. Decoding Algorithm. Gene Prediction. Analysis. Regulatory Motifs in DNA Sequences. Hash Tables. Reconstructing Trees from Additive Matrices. k-Means Clustering . Large Parsimony Problem. Spectral Convolution. HMM Parameter Estimation. The Manhattan Tourist Problem. Jones and Pavel A. 2. A Practical Restriction Mapping Algorithm. Small Parsimony Problem. Randomized Algorithms: The Sorting Problem Revisited. Graph Algorithms: Graphs and Genetics. Edit Distance and Alignments. Gibbs Sampling.

series. B. 4. gas phase pressurized and non-isothermal). 1999. isothermal. direct substitution. from process to information flow diagram. Module II Optimization: Single variable optimization (analytical. Recycles. Batch distillation. Equilibrium. Single component vaporizer. Luyben. L. Optimisation Techniques for Chemical Engineers.T. etc. fibonacci. V.R. ************** . Module III Simulation:. Simulation and Control for Chemical Engineers. Reactor with mass transfer. Process Plant Simulation. Bequette. Techniques of digital simulation – Information flow. Babu. Macmillan. Oxford University Press. Essential Reading: 1. S. golden section. B. Process Modelling. Equations of state. S. Multi-component flash drum. 1990. (single. Batch reactor. Suggested Readings: 1. Process Control: Modeling. variable hold up. Lumped and distributed parameter models – Fluid systems. Gangaiah. dichotomous search. Transport equations.S. 3. geometric programming. Rao. A. PROCESS SIMULATION AND MODELLING (3-0-0) Module I Modeling: Fundamentals of mathematical models and formulation – Continuity equation. Engineering Optimization: Theory and practice. Hussain and K. linear programming). 2004. Chemical kinetics and their applications. C. New Age Publishers. 2001. Equation of motion. From information flow diagram to numerical form. Multivariable optimization (analytical. Wegstein’s method). Convergence methods (Newton’s methods. Ideal binary distillation column. Energy equation. Calculation of a recycle set. W. Heat exchanger. McGraw Hill. W. regula falsi). etc. Prentice-Hall India. Design and Simulation. 2006. 2. constant hold up.