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DOI: 10.5114/pm.2014.

46472

Prz Menopauzalny 2014; 13(5): 298-304 Review paper

Cellulite in menopause

Marta Leszko

Department of Cosmetology, Regional Unit of Physical Education and Sport Department in Biaa Podlaska,
Jzef Pisudski Physical Education Academy in Warsaw, Poland

Abstract

Menopause is aphysiological process related to the increasing insufficiency of the hypothalamic-hypophy-


seal-ovarian axis. The pool of ovarian follicles capable of synthesizing female sex hormones becomes gradually
depleted. In response to the sequence of endocrine changes of premenopause, perimenopause, and postmeno-
pause, systemic somatic and emotional disturbances appear. Skin is the target organ for sex hormones. In
women, the trophicity and appearance of the skin are most significantly affected by female sex hormones,
estrogens and progesterone. However, this review also emphasizes the influences of other hormones on the
skin and subcutaneous tissue.
During menopause, alow estrogen concentration is responsible for increased vascular permeability and de-
creased vascular tone, which lead to microcirculation impairment and are important factors predisposing to the
development of cellulite. The effects of estrogen deficiency on the skin connective tissue include adecreased
production and topical content of both type Iand III collagen and elastin fibers, which also contributes to cellulite.
This paper presents diagnostic methods and clinical types of cellulite, as well as principal instrumental and
manual treatments used for the reduction of the condition. Preparations containing ingredients which help to
improve the metabolism of subcutaneous fat and enhance blood and lymphatic circulation, applied in cosmetol-
ogy and esthetic medicine practice, have been reviewed. Furthermore, we provide an array of opinions regarding
the effectiveness of treatment modalities presented here.
Key words: menopause, cellulite, hormones, microcirculation, oestrogen(s).

Introduction
because of disorders of the microcirculation, degenera-
The period of menopause is usually along-standing tive changes of the connective tissue occur. Cellulite is
running process with stormy hormone changes which more and more often treated as illness, since as the
are manifested with somatic systemic disorders and definition of WHO demonstrates, it more and more of-
the lability of the emotional sphere. Apool of Graafian ten negatively influences amental state of both women
follicles, responsible for the production of female sex and men [3].
hormones, yields to the exhaustion. Hormone deficien-
cies can result in many dermatoses and may as well
increase already existing manifestations. Frequently Cellulite aetiology
appearing skin defects are a consequence of these Hormonal imbalances are regarded as the crucial
disorders, so are discolourations, hirsutism or cellulite. cause of the cellulite, and more precisely too high
Correctly selected therapy is able to improve the ap- concentration of oestrogens compared to the pro-
pearance of the skin, and through that increase the gesterone, that is relative hyperestrogenism [4]. Such
quality of life of menopausal women. ahormone situation can appear physiologically in the
period of pregnancy, maturation, menopause, as well
as while taking the systemic hormone contraceptive or
Definition of cellulite
in the course of the hormone replacement therapy. De-
The notion of cellulite was first defined by French velopment of cellulite is significantly influenced by two
doctors in 1922 [1]. From amedical point of view, these processes constantly occurring in fat cells lipogenesis
are fibrous and oedematous changes of the subcuta- and lipolysis.
neous layer, lipodystrophy or oedemetical, fibrosing In the fatty tissue built from adipocytes, synthesis
deviation of the connective tissue [2]. In this disease, and disintegration occur. Lipogenesis is supporting the

Corresponding author:
Marta Leszko, MSc, Department of Cosmetology, Regional Unit of Physical Education and Sport Department in Submitted: 17.02.2013
Biaa Podlaska, Jzef Pisudski Physical Education Academy in Warsaw, 15/30 Sokola St., 20-336 Lublin, Poland, Accepted: 01.10.2014
phone: 501 067 177, e-mail: marta.leszko@gazeta.pl

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accretion of the fatty tissue, however lipolysis is amet- creased secretion of neuroendocrine can be aresult of
abolic process which causes the decomposition of the stress, affecting women in their menopause. Increasing
stored-up fat. Exogenous and endogenic factors affect the secretion of the noradrenalin shows the lack of the
both processes. In the prevention of cellulite, it is im- stability of the autonomous nervous system. In the pe-
portant to keep balance between both processes. Local riod, the increased production of cortisol is connected
therapy is aimed at achange of the adipocyte metabo- with the climacteric and at the same time with agreat
lism and should limit lipogenesis and activate lipolysis. concentration of adrenaline and noradrenalin [9].
Lipolysis is aprocess of destruction, disintegration Mostly oestrogens are the hormones responsible for
and the reduction of lipids stored up in cells of the fatty the development of cellulite, as they are responsible for
tissue and muscle occurring with the participation of li- arranging the fatty tissue. In women, the production of
pases. Endogenic factors regulating the lipolysis include the fatty tissue is independent of the amount of food
such hormones and neurotransmitters as adrenaline eaten. The development of the fatty tissue is subject
and noradrenalin (demonstrating poorer action than to an adjustment of local hormone mechanisms. Aro-
adrenaline), estradiol and testosterone, adrenocorti- matase, which is elevated in the period of the meno-
cotropic hormone (ACTH), growth hormone (GH), thy- pause activity, modifies the deficiency of ovarian oestro-
rotropin (TSH, thyroid stimulating hormone) and lep- gens [10], as well as it influences the lipid and glucose
tine, antidiuretic hormone and glucagon. Adrenaline metabolism. This process causes the increase in adi-
being connected with receptors on the surface of 3 pocytes, which under the influence of the pressure on
adipocytes activates G protein which excites adenyl blood vessels and lymphatic vessels causes the growth
cyclase and in the end increases cyclical AMP (cAMP). of the local pressure, burdening, and also microcircula-
Protein kinase activated by cAMP stimulates the HSL tion. Shortage of the sex hormone in the menopause
(hormone-sensitive lipase) causing the disintegration exerts an adverse influence on the vasculature [8]. It
of stored up lipids. was proved that there is aclose relationship between
Neutral fat lipase (known as desnutrin) hydrolyzes disorders of the venous circulation and pathological
triglycerides (TG) to diglycerides, and HSL decomposes changes in the fatty tissue [3].
diglycerides to monoglycerides [5]. Glycerol and free PPAR nuclear receptor affects the metabolism of the
fatty acids are final products of the lipolysis (free fatty fatty tissue. Receptors are one of three kinds of PPAR
acids), being energy sources for cells. gamma receptors which influence the maturing and
Insulin which is suppressing the initiative of cyklase diversifying of adipocytes. They stimulate the accumu-
is the hormone blocking the process of lipolysis and it lation of lipids and increase the synthesis of adiponec-
stimulates activity of lipoprotein lipase (LPL), respon- tin [6]. PPAR-a receptors are the second kind of units
sible for the synthesis of lipids and the capture of free which influence -oxidation of free fatty acids and
fatty acids. The process of lipogenesis is also depend- serve as adjusters in lipogenesis [11]. Activated recep-
ent on SREBP-1 transcripting factor whose expression tors through peroxisome proliferators of PPAR retinal
is increased by insulin. For this reason, alow concen- acid and conjugated linoleic acid (CLA) influence the
tration of this hormone can support the lipolysis pro- lipolysis process [2]. Oestrogens activate the action of
cess [6]. adrenergic receptors of the a type, and support the ac-
According to the theory of adipocytary receptors, cumulation of fatty tissue in the region of thighs, hips
a receptors intensify lipogenesis, however b receptors and the pelvis, as well as influence the extension and
support lipolysis. Adrenaline, belonging to catecho- increase the permeability of blood vessels. This results
lamines, comes mainly from adrenal medullae and in the occurrence of microembolisms and microswell-
fibres of the sympathetic nervous system, and the ings. Oestrogens hinder the process of lipolysis and el-
stimulation of fat cells is one of its roles with a- and evate lipogenesis. They influence the increased amount
b-adrenergic receptors. An influence on both kinds of of glycosaminoglicans (Gag) which is contributing to
receptors is an effect of its acting. The amount of b adr- impairment of the microcirculation (accumulating liq-
energic receptors is reduced under the influence of such uid in the intercellular space creates swelling which
factors as age increasing the amount of the fatty tis- causes disorders in the microcirculation).
sue which extorts the response of a receptors. It can Progesterone has arelaxing effect on the fibres of
be the reason for the accumulation of fatty tissue in smooth muscles and can cause the venostasis trig-
menopausal women. This relation causes the potential gering disadvantageous morphological and functional
undesirable effect of anti-cellulite therapies [7]. changes [3]. Disorders in the microcirculation may
Catechol amines speed up the process of the me- cause alocal rise in pressure and support the increased
tabolism via b receptors, affecting carbohydrates and permeability of veins which is supplying the slow blood
fats economy [8]. The consequence of hypoestrogenism flow and increases the viscosity, creating the leuko-
is the upset in the balance between noradrenalin, do- cytary trap. In individual periods of the menopause, an
pamine, serotonin or endorphins in the menopause. In- impact of subtle interactions on development of the

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cellulite is also being considered, namely the impact of Improperly selected clothes and footwear, especially
oestrogens and other hormones, such as progesterone, wearing too close-fitting clothes, is definitely disturbing
growth hormone, melatonin, dehydroepiandrosteron, the venous outflow. Also high-heeled shoes, through the
androgens or insulin which can additionally entail adverse impact on muscles of calves, disturb the good
changes associated with the wrong transformation of posture and weaken the function of the muscle pump
fats and carbohydrates. of shins in transferring the venous blood to the heart.
In the premenopause, in spite of lowering concen- In the prevention of cellulite, it is very important to
trations of the plasmatic estradiol, escalating luteal de- pay attention to all factors predisposing to its formation.
ficiency caused by more and more rare ovulations can Some factors having asignificant influence on cellulite,
translate into the state relative to hyperestrogenism, as for example genetic factors, are outside the range
and this creates conditions for initiation of growth of of any possible alteration, therefore it is worthwhile to
the fatty cellulite along with the tendency of swellings. concentrate on the elimination of factors, which we can
Another issue is strongly expressed postmenopau- have areal influence, like the change of the inappropri-
sal hypoestrogenism, as the maintained peripheral ate diet or introducing amore active lifestyle.
production of androgens, can cause relative hyperan-
drogenism in older women [12], which can influence
the change of arranging of the fatty tissue which sur- Clinical image of cellulite
renders to reduction among others in places typical of Clinically, nodular, uneven forming of the surface
women, and develops in the belly and torso regions as of the skin is asign of cellulite. From amedical point
well as supports androidal (visceral) type of the build of view, the structure of the tissue with cellulite differs
[13]. With age, reduced stimulation of oestrogens wors- from the fatty tissue above all with the increased num-
ens the blood supply to the skin, suppresses the initia- ber and the hypertrophy of adipocytes and with dis-
tive of fibroblasts, disadvantages normal synthesis of turbed proportion between saturated and unsaturated
collagen fibres and reduces the number of elastin fibres. fatty acids included in these cells, unfortunately to the
Under the skin there can occur perceptible palpable ir- advantage of saturated fatty acids [7].
regularities conglomerations of the bruised connec- Characteristic of both sexes, differences associated
tive tissue underlined with the lack of the skin elastic- with the structure of the subcutaneous fatty tissue
ity. Such changes are characteristic of the slender figure cause that lipodystrophy appears mainly in women, and
of the cellulite. in men exclusively in pathological states and while ap-
Amongst factors predisposing to the development plying anti-androgen therapy (e.g. in the prostate can-
of cellulite, rather than resulting directly from hormo- cer treatment). The cellulite in men is located within the
nal disorders, one should mention mostly the genetic neck and belly [7].
factors. Family tendencies exist to wrong deposition of In women cellulite most often appears in regions
the fatty tissue and its characteristic organization at of thighs, the belly and buttocks, in places, which have
simultaneously underdeveloped muscle mass. Bad eat- alot of the receptors responsible for the lipogenesis [2].
ing habits are other non-hormone risk factors for the So far no one has managed to prove the connec-
development of cellulite. The increased supply of car- tion between cellulite and obesity, since cellulite also
bohydrates and fats supports hyperinsulinemia which, appears in slim and active persons.
among others, intensifies the process of lipogenesis and It is possible to distinguish three main clinical types
is one of deciding aetiological factors. Badly balanced of the cellulite:
diet with alot of preservatives and salt in the food sup- fatty by the overdeveloped fatty tissue;
ports retention of liquids which results in swellings. lymphatic transitional, intensified mainly before
Other factors are low physical activity and aseden- the menstruation;
tary lifestyle which disturb correct functioning of the alleged appearing because of weakened ten-
microcirculation and support the accumulation of fatty sion of the gluteus muscle, visible on the back of
tissue. thighs; it is possible to improve this state through
Nicotine and many other substances contained in the right exercises [14].
the cigarette smoke cause constriction of blood vessels On account of character of skin changes it is pos-
which supports tissue hypoxia. After certain time, loos- sible to divide cellulite into:
ened vessels and the improvement in oxidation condi- tough type (in women practising sports where the
tions result in allowing reactive oxygen species to act in great cohesion of the skin and the well-developed
the process of hypoxia the reoxygenation. musculature are characteristic);
Dilators of the peripheral blood vessels applied in slender form (in women of the perimenopausal
the arterial hypertension can affect the development of age, is also appearing after dieting; pliability of
the cellulite: b-blocking agents, antihistamine and ex- muscles is characteristic, the skin is poorly tense
ogenous oestrogens [4]. and loose);

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Tab. I. Photonumerical scale of cellulite intensification

Clinical morphological features of cellulite advancement Result


1. Number of visible thickenings 0 = absence of thickenings
1 = small number; 1-4 visible thickenings
2 = average number; 5-9 visible thickenings
3 = high number; 10 and more visible thickenings
2. Depth of the thickenings 0 no changes
1 superficially deep changes
2 mild deep changes
3 deep changes
3. Various morphological models of superficial models of skin changes 0 no affected areas
1 orange skin look
2 cottage cheese look
3 mattress look
4. Level of loosening and relaxation of the skin 0 absence of visible changes or skin creasings
1 light creasings
2 mild creasings
3 numerous creasings
5. Nrnberger and Mllers classification scale in the standing position 0 zero degree
subjected to pinching test (at the relaxed buttock muscle there may
1 first degree
not be visible creases; this allows to differentiate 0 from 1)
2 second degree
3 third degree

hydropic form (the most severe form, appears in tion assesses the state of the filling of capillaries: in the
women with serious disorders of the cardiovascu- place of the advanced cellulite the tissue is poorly sup-
lar system) [2]. plied with blood), electric bioimpedance (determines
content of the fatty tissue and water in the body).
However in the diagnosis of cellulite, computed axial
Cellulite diagnosis tomography, magnetic resonance and ultrasonography
Cellulite is diagnosed by acosmetologist or ader- turned out to be extremely useful.
matologist. Apalpable medical examination and avis- But neither the computed axial tomography nor the
ual evaluation are the basis of assessment of cellulite. magnetic resonance can be universally used on account
There are many scales of the evaluation of cellulite of their costs and in the case of the computed axial to-
(Table I). Ascale that is universally used is Nrnberger- mography as for the radiation exposure to X-ray. There-
Mllers scale. The scale of 2009 Doris Maria Hexsels fore, ultrasonography is more and more general and
photonumerical scale of cellulite intensification is objective than the palpable scale. The research on the
newer and regarded more exact (Table II). Based on pho- evaluation of cellulite is performed basing on classical
tographs of 55 patients with cellulite, five key aspects ultrasound scanners and of high frequencies.
were distinguished in the assessment of this problem. Classical ultrasonography assesses such parameters
A new classification mentions three stages of cel- as fatness of the corium and, of the subcutaneous layer,
lulite advancement: echogenicity of both structures, and the border between
Aphotonumeric scale of intensifying changes in cel- the corium and subcutaneous layer [16]. In the high
lulite is extremely valuable in monitoring therapeutic frequency ultrasonography it is possible to assess the
anti-cellulite methods and can be applied for examin-
ing affected patients [15]. Tab. II. Structure of cellulite intensification scale and its new
It is also possible to assess cellulite basing on spe- typology
cialist examinations: thermography (it determines the
Cellulite intensification scale New typology
temperature of the surface of the body, and colours are
indicating the temperature of the tissue), macrography, 1-5 Mild form
TEWL determination (measurement of transcutaneous 6-10 Average form
dehydration), the apparatus measurement of greasing
or the skin elasticity, videocapillaroscopy (the examina- 11-15 Advanced form

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following parameters: the fatness of the cuticle and co- method, in which three energy sources are used:
rium, presence of swellings, echogenicity of corium and infrared, bipolar electricity of high frequency (RF),
what is most essential, the advanced process of forming the impulse suction and massage. Their cooperation
the root of the corium in the subcutaneous layer [17]. considerably increases the effect in comparison to
results obtained when using single energy sources.
All three energies are being administered to the tis-
Methods of cellulite treatment sue simultaneously, using one therapeutic head. The
Treatments aimed at reduction of cellulite should be treatment comprises 10-12 sessions which are taken
conducted comprehensively and should have a multi- twice aweek for 5-6 weeks [20].
directional action. One should be aware that they will Triactive three various methods are being used
not eliminate the problem, and they will only slightly re- for the treatment: the diode laser, cryotherapy, deep
duce its area and therefore will affect the temporary im- massage and lymphatic drainage. The diode laser
provement in the appearance of the skin. Nevertheless, stimulates the reconstruction of vessels in the sub-
this result can be essential for menopausal women. cutaneous layer, cryotherapy reduces swelling and
Methods reducing cellulite are cosmetic procedures, lymphatic drainage and massage stimulate blocked
cosmetic surgery, pharmacology, and surgeons pro- circulation of lymph expelling water and unnecessary
ceedings. products of metabolism from the organism. Series are
The basis of home therapy is: usually applied in about 10-15 treatments 1-2 times
1. Application of cosmeceutics, containing active in- aweek [20].
gredients: SmoothShapes the device is using three techno
Improving the tightness of blood and lymphatic ves- logies connecting the laser, biostimulating light,
sels, e.g. flavonoids, antioxidants, saponins, tannins, massage with rolls and vacuum [20].
which also help eliminate unnecessary products of Alma Accent RF system the device is asource of
metabolism. The above-mentioned group of sub- high frequency waves for collagen remodelling, im-
stances appear in extracts from arnica, and seeds and proving texture of the skin and cellulite reduction. It
leaves of the horse chestnut. uses two types of radio frequency: unipolar and bipo-
Intake of compounds of plant origin increases the lar. By proper applying different heads for heating (of
process of lipolysis, but suppresses lipogenesis such heat treatment), appropriate layers of the skin and
as caffeine, extracts from guarana, Garcinia gummi- the subcutaneous layer are treated.
gutta, theophylline, xanthine (come from coffee, the IR rays trigger thermogenesis after which the reduc-
green tea and the Paraguayan tea). tion in fat cells takes place.
Toning and moistening substances applied in anti- The techniques of the cellulite reduction include
cellulite cosmetology: hyaluronic acid, vitamin A and strictly medical aesthetic treatments:
E, urea, plant extracts, amino acids and hydroxyacids. Liposuction during the treatment alocal excess of
2. Supplementation is based above all on products fat is removed operation performed by surgeons.
containing caffeine and vitamin B1s, B5, B9 and B12. Liposuction can be made with the help of lasers and
Physical activity, sport, appropriate diet. Apreventive apparatuses producing airwaves. In medicine, apply-
program containing information about factors affect- ing high frequency waves causes effects of the over-
ing the development of cellulite and methods of its heating of tissues. Modern apparatuses are equipped
elimination. The basis of precaution and also of elimi- with the cooling system that prevents burns of the
nation of risk factors is: skin (cryogenic liquid) and exchangeable treatment
preventing the development of the advanced heads. The treatment consists in the proper dosage
stage of the cellulite, most resistant to therapy. It of airwaves, of which the energy is turned into the
is also important to make women aware of the central heating, stimulating cells to produce collagen;
need of periodic medical check-ups. waves work on the corium and the subcutaneous
The most popular treatments in the cosmetic and layer. The treatment improves firmness and density
cosmetic surgery areas applied to reduce the cellulite are: of the skin [20].
Lymphatic drainage works positively on lymphatic Mesotherapy method consisting in applying subcu-
vessels, eliminates swellings, is also beneficial for taneous injections with nutrients and healing agents
deep layers of the skin. (silica, caffeine, tiratricol). It assists the lipolysis which
Endermology apparatus massage; increases oxida- reduces cellulite, but it does not directly affect the fat
tion of tissues, improves skin elasticity, hastens the tissue causing cellulite.
apoptosis of fat cells, however does not strengthen Injection lipolysis lipolysis can be applied to sup-
the corium [18-20]. plement liposuction, but cannot replace it; the treat-
Velasmooth is at present the most effective appli- ment consists in the reduction in the local fatty tissue
ance in the treatment of cellulite in a non-invasive with the injection; phosphatidylcholine has most of-

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ten been applied and sodium deoxycholate, but both Good effects are obtained by combined therapy.
are registered for this purpose. At present for the These are most often treatments from the cosmetic
injection lipolysis surgery, one uses a new injection area, connected with applying cosmeceutics, with an
technique intralipotherapy which was registered increased physical activity and appropriate diet. Even
in 2007 and popularised by Professor Motolese as though they will not get rid of the cellulite permanent-
Aqualyx preparation. Gel is also applicable in the no- ly, they will improve the general state of the skin, and
needle mesotherapy against defluvium Dermaheal hence improve self-assessment of women in the period
HR. Professor Maurizio Ceccarelli is using vitamin C of the menopause.
and iron for the lipolysis which causes the apoptosis
of fat cells.
Cryolipolysis consists in exploiting cryotherapy and is Conclusions
applied for the reduction of the fatty tissue. Under the Cellulite is a clinical state stirring up a lot of con-
influence of the low temperature, cell membranes of troversy. There is explicitly no effective method of get-
adipocytes are yielding to injury. Next, lipids undergo ting rid of this disease [22]. From the point of view of
crystallization, what in the end leads to their apop- physiology, preparations recommended by producers as
tosis. Lipids from adipocytes are consumed by mac- those getting rid of cellulite demonstrate limited effica-
rophages. During one treatment not always we can cy. By definition, cosmetic substances crossing border
destroy all cells treatment performed by dermatolo- layers of the cuticle do not demonstrate the effective
gists and surgeons [14]. action towards changed tissues. Cosmetic substances
Same as all medical treatments, anti-cellulite treat- apriori cannot reach changed tissues.
ments should always be preceded by athorough inter- Only products including in their composition accel-
view and medical consultation. When choosing treat- erators of percutaneous passage, such as ethanol, iso-
ment, especially for menopausal women, one should propanol, propylene glycol or -hydroxyacids can facili-
take the current medical condition into account, be- tate transport of active ingredients which can affect the
cause diseases coexisting in this period can often make metabolism of the fatty tissue. Assuming that cellulite is
the treatment impossible. The contraindication for in- astate resulting from changes of the structure of the fatty
tensive manual and apparatuses treatments is diseases tissue, it is understandable that the motor activity cannot
already frequent in this lifespan, including arterial hy- be an effective method in itself of getting rid of the cel-
pertension, osteoporosis, type 2 diabetes and the ve- lulite. This problem affects both slim and obese women.
nous failure. Regularly applied treatments made with the help
Pharmacological therapy is considerably popular for of apparatus, provide satisfactory, but short-lived, ef-
improving the appearance of the skin with the cellu- fects. Amongst methods listed in the article, abenefi-
lite. In women applying hormone replacement therapy cial effect of massage should be mentioned, and more
(HRT), by no means, quality and an amount of the ac- precisely the fact that exerted pressure on adipocytes
cepted gestagenic component, or the route of admin- blocks their diversification, which makes the accumu-
istration, should be considered as marginal. In oral lation of fatty tissue impossible [23]. Gentle massage
administration, mineral corticosteroid activity of ge- with elements of aromatherapy is peculiarly recom-
stagen can stimulate the system: renin-angiotensin- mended for women in the menopausal period, since
aldosterone which stops water and electrolytes in the added oils not only work favourably on the state of the
system. Activity of glycocorticoid may cause contrac- skin, but also improve the psychological condition.
tion of blood vessels, dismissal of the blood flow and One should nurse ahope that research works of the
venostasis, as well as blood coagulability among others nearest years will verify the effectiveness of new thera-
[17]. Androgenic activity of gestagen entails negative pies and will allow us to gain more information about
changes in the profile of lipids of blood, increasing local the cellulite.
atherosclerotic processes [21].
In other words, disorders of the microcirculation
Disclosure
are common characteristics of adverse reactions of
the gestagenic hormone replacement therapy, one of Author reports no conflict of interest.
important factors in the aetiology of cellulite. The per-
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