Documentos de Académico
Documentos de Profesional
Documentos de Cultura
Declaracin de intenciones
- Glaucoma experimental
- Glaucoma humano
Apoptosis/Necrosis
neuronal
Ca2+ Autoinmunidad
Factores
neurotrficos
Apoptosis de las CGR. Va intrnseca y extrnseca
Base molecular de la muerte de las CGR en glaucoma
Proneurotrofinas txicas
Disfuncin mitocondrial
Excitotoxicidad
Stress oxidativo
Gla reactiva
ANTIAPOPTOTICAS
Factores neurotrficos
PROAPOPTOTICAS
Protenas BID agonista del dominio de muerte que interacta con BH3
NCT00168350
Antagonista del recptor NMDA. Glaucoma primario
Allergan (completado)
Memantina Protege a las CGR y a sus sinapsis de ngulo abierto
a nivel del NGL (Fase III)
Neuroprotection for treatment of glaucoma in adults.
Sena DF, Lindsley K. The Cochrane Library 2013.
Data collection and analysis: One trial was identified for this review, thus we
performed no meta-analysis. Two studies comparing memantine to placebo are
currently awaiting classification until additional study details are provided. We
documented reasons for excluding studies from the review.
LoGTS. Timolol vs Brimonidina
LoGTS. Timolol vs Brimonidina
At present, there is not enough evidence to show whether medicines used to protect the
optic nerve and optic cells work. (Cochrane, 2013)
Frmacos hipotensores tpicos con potencial efecto neuroprotector
- Apraclonidina - Bimatoprost
- Latanoprost
- Brimonidina
- Tafluprost
Bloqueantes :
- Travoprost
- Betaxolol
Inhibidores de la anhidrasa carbnica :
- Levobetaxolol - Apraclonidina
- Brimonidina
Dianas en Neuroproteccin
Frmacos hipotensores. Bimonidina
- Fototoxicidad INL
- PI3K/Akt
Se ha sugerido un efecto a nivel de los
receptores NMDA
At present, there is not enough evidence to show whether medicines used to protect the
optic nerve and optic cells work. (Cochrane, 2013)
At present, there is not enough evidence to show whether medicines used to protect the
optic nerve and optic cells work. (Cochrane, 2013)
Glutamato
Na+ Estimula la formacin de
Dao Membrana fosfatidilcolina
Na+ Despolarizacion (Lopez Coviella, 1995; Wang, 2000)
Fracaso bomba ION
Fracaso Muerte celular aguda
produccin energa
receptores
mitocondrial radicales
NMDA Perdida ATP libres
Glutamato Ca2+ Inhibe la activacin de fosfolipasa A2
fracaso
Energa y previene la acumulacin de cidos
transicin de (prdida ATP) grasos libres
permeabilidad
Na+-glutamato
co-transporter
NOS (Rao, 2001)
Citocromo C
Glutamato ON
At present, there is not enough evidence to show whether medicines used to protect the
optic nerve and optic cells work. (Cochrane, 2013)
The supplementation with citicoline might significantly slow down glaucomatous rates of
progression. (Ottobelli et al, 2013)