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COSMOS 73
COVER STORY & FEATURES
CONTENTS
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48 56 26
ANTONIO REGALADO reports Climate advocate believes the Our picture of the Red Planet
on the hopes of new cures from private sector is the answer. has never been clearer, by
gene therapy 2.0. LINDA MARSA reports. JAMES MITCHELL CROW .
4 CONTENTS Issue 73
COSMOS 73
DISPATCHES, ESSAYS & REVIEWS
UPFRONT
DIGEST
PAGE 65 VIEWPOINT
SPECTRUM
WHY IS IT SO? 78
GIVE SCIENCE
NOT SOCKS
PUBLISHERS NOTE
customers or at info@cosmosmagazine.com
So thank you for your support and, from everyone
at Cosmos, a happy and prosperous 2017.
COSMOS UPFRONT 7
EDITORS NOTE
Giving us the edge set halfway to the edge of the universe; SKA-low
is aiming for the very edge. To do so, it needs
technology yet to be developed. Thats because its
THE TELESCOPE that goes by the name Square a software telescope. Not majestic dishes like those
Kilometre Array will be the largest global, to be deployed in the Karoo, but a forest of antennae
collaborative science project ever. If all goes to plan, whose signals are combined to achieve sensitivity
in 2018 the first of 130,000 antennae will be rolled and resolution. Together they will multiply into
out on a remote red plain a few hundred kilometres a telescope 168 times more powerful than current
north-east of Geraldton, Western Australia. A sister equivalents such as LOFAR in the Netherlands.
ELIZABETH FINKEL telescope will be built on another remote red plain, To get a clear image of the early universe,
Editor-in-chief the Karoo, about 600 kilometres north-east of Cape SKA-low will have to crunch data at an
Town, South Africa. unprecedented scale greater than the entire
Overall, this is a complex, vast, daunting global internet traffic per day.
project. Myopic journalists struggle to get its Thats the second reason we should be falling off
measure. Its the elephant problem; heres a tail, our chairs. The innovations that will emerge from
theres a tusk, but what is this entire monstrosity this big data project promise huge windfalls. The
all about? Thats a concern because this is an Word Wide Web was the spin-off when CERN the
extraordinary beast: we should all be falling off home of the Large Hadron Collider needed to find
our seats in excitement. a way to manage its big data problem. Wi-Fi was
There are at least two reasons. First, theres the offshoot when CSIRO researchers learnt how
the sheer audacity of it SKA-low, the telescope to realign the scrambled signals from black holes.
to be built in Australia, will fill in a missing chapter Which is why companies are already flocking
in the history of the universe: how did we get from to Western Australias capital city, Perth. Cisco,
a featureless sea of neutral hydrogen to galactic Woodside, Google and Chevron are getting
islands separated by a thin sea of ionised hydrogen? involved.
Theorists have had free rein to model elaborate This conglomerate of astronomers, computer
scenarios on their computers. The SKA-low data, geeks and industry is a far cry from the romance of
expected to come online in 2021, will at last put Galileo, grinding his lenses into a telescope, gazing
these models to the test. heavenward and discovering the moons of Jupiter.
SKA-low is the most ambitious of the two But how he would have swooned to see the first
telescopes. SKA-mid, in the Karoo, has its sights images from the edge of our universe.
ISSUE 73
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8 DIGEST Issue 73
DIGEST
LIFE SCIENCES
The folding on the right side of this mouse LIFE SCIENCES Lucy, social climber 13
embryos cortex reflects the increased growth
EARTH SCIENCES Earths spin is slowing 14
stimulated by the insertion of a human gene into
that side of the brain. LIFE SCIENCES Glimpse into how feathers evolved 15
CREDIT: MARTA FLORIO / WIELAND B. HUTTNER / MAX PLANCK INSTITUTE
TECHNOPHILE The eyes have it 16
OF MOLECULAR CELL BIOLOGY AND GENETICS
10 DIGEST Issue 73
trillions of times faster than lights current foggiest about what caused inflation, nor
30
speed to explain the even temperatures why it stopped. And physicists havent
measured across the early universe. found any direct evidence to back it up.
Imagine switching on a heater in a cold Now, writing in Physical Review D, Weight, in kilograms, the coconut crab
concert hall and having the whole space Magueijo and colleague Niayesh Afshordi, (Birgus latro) the worlds largest
warm instantly. A similar cosmic-scale have hit back with a refined superfast light land-dwelling crustacean
effect has been puzzling physicists since theoryalong with a testable prediction can lift with its powerful claws.
the 1960s, when the the cosmic microwave that seems right on the money. Until recently, no one knew
background (CMB), the oldest light in the The refinement proposes that at first, exactly how much force
universe, was found to be the same colour light travelled far faster than gravity before those pincers could exert.
in all directions. settling down to its current speed.
The new theory spits out an exact
prediction for a feature of the cosmic
microwave background called the spectral 3,300
index. Although the CMB is pretty much The newly calculated pinching force,
the same in all directions, there are some in newtons, of a coconut crabs pincers,
slight variations--the picture is a teensy according to a November PLOS One
bit splotchy. The spectral index captures study by Japanese biologists.
these variations. The prediction proposes
2,200
a precise number for the spectral index.
Laying out a testable prediction
is a badge of honour in the somewhat
A tigers average bite force, in newtons.
nebulous world of theoretical physics,
And humans? Our maximum bite force
where theories can often be retrofitted
is a measly 900 newtons.
to match the latest data. Their predicted
A conundrum: the even temperature of splotchiness is close to the latest data
the early universe, evidenced by this map from the Planck satellite. But Magueijo
of the cosmic microwave background, and Afshordi know better than to get
suggests light once trarvelled much faster too excited: Improved observations will
than it does today. soon vindicate or disprove this model,
CREDIT: ESA / THE PLANCK COLLABORATION they note.
12 DIGEST Issue 73
deep in Earths crust to the surface and Then the researchers compared the
made it behave like a liquid, shooting up models with bone scans of other early
into the air like a geyser before collapsing hominins, modern humans and modern
LIFE SCIENCES
into the basin and settling out into chimpanzees.
a circular ridge around the centre. Lucys arm bones, it turns out, were
The study adds to a small but growing much stronger than her leg bones, and
body of evidence in support of the dynamic Lucy, social climber the weaker structure of the leg bones
collapse theory of peak ring formation in meant she probably had a somewhat
craters. Last October, scientists reported awkward, inefficient gait compared to later
The early hominins strong arms suggest
that the peak rings within Mare Orientale, hominins. It seems likely, then, that she
a life lived aloft. APRIL REESE reports.
a crater on the moon, formed in a similar lived a primarily arboreal life, relying more
way. on her arms to get around than her legs,
Geophysicist Penny Barton from Lucy, the worlds most famous early the researchers conclude.
the University of Cambridge, who was hominin, may have walked on two legs Although bipedal when on the
not involved in the study, writes in a but she preferred to climb among the ground, the limb bone structural
Science commentary on the discovery trees, a recent study suggests. proportions of [Lucy] provide evidence
that it appears to validate the collapse In the decades since the 1974 for substantially more arboreal, i.e.
models while also posing many new discovery of the 3.18-million-year-old climbing behaviour than either modern
questions for further work on these Australopithecus afarensis fossil, scientists humans or Homo erectus, the researchers
exciting samples. have debated whether Lucy lived primarily write in the study, published in PLOS One
on the ground or in the trees. in November.
Hoping to settle that debate, Staying off the ground would have
THE PEAK RINGS WITHIN MARE
a team led by Christopher Ruff at Johns helped keep Lucy safe from predators,
ORIENTALE, A CRATER ON THE MOON,
Hopkins University in the US scanned but it also posed its own risks: an earlier
FORMED IN A SIMILAR WAY.
Lucys arm and leg bones to create study found that she died by falling from
detailed 3-D models of their structure. a tree.
One of those questions is how the
rocks were weakened enough to behave
like a fluid. The team is now attempting
to find out.
How the Chicxulub peak ring formed
isnt the only question researchers
involved in the US$10 million core
drilling project hope to answer. They
also aim to glean other insights into
Earths most famous cataclysm and its
effect on the planet.
Four labs are testing core samples for
iridium, a metal that asteroids sometimes
leave behind. While the space rock would
have vaporised on impact, bits of it likely
settled into the crater.
So far, the search for iridium in the
cores has come up empty, but in December
researchers told a meeting of the American
Geophysical Union they had the next best
thing: nickel, which behaves similarly to
iridium and serves as a kind of proxy for
the presence of asteroid dust.
Researchers hope the hundreds of
metres of core samples from the site will
also reveal more about how the crater
formed, how the material it churned up
was dispersed and how long it took life Recent scans of Lucys skeleton showed the bones of her arms were stonger than those
to rebound at the site. of her legs she was therefore probably a tree-dweller. CREDIT: DAVE EINSEL / GETTY IMAGES
14 DIGEST Issue 73
but not as much as Pluto and its moon Charon, with their
HEART predicted
smaller masses, are already there. Physics
equations tell us Earth will realise this fate
billions of years from now.
But the British astronomers wanted
Scientists used ancient records to calculate
something a little more precise. So they
the slowdown BELINDA SMITH reports.
spent four decades scouring records of
historical eclipses including those of 8th
When ancient astronomers carved century BCE Babylonians, the 2nd century
cuneiform figures recording solar eclipses Almagest penned by the Greek astronomer
on to clay tablets, little did they know they Ptolemy, centuries of Chinese dynastic
were providing baseline data for an epic records and observations from Arab
science experiment. astronomers from about 830 CE to
Some 2,700 years later, a trio of 1020 CE.
British scientists from the University Some of these observations timed
of Durham and Her Majestys Nautical how long it took for the Moon to cross
CREDIT:K H FUNG / SPL / GETTY IMAGES Almanac Office used these and other the path of the Sun a measure of the
historic records to calculate that an Earth Earths rotation speed. They found that,
day grew by an average of just under two- on average, the length of Earths day
A zebrafish is unlikely to die of
thousandths of a second each century. increased at a rate of 1.8 milliseconds
a broken heart. The fish, about the
Their findings appeared in the Proceedings per century somewhat lower than the
size of your pinky, can lose a fifth
of the Royal Society in December 2016. predicted value of 2.3 milliseconds. This
of its heart and grow it back. Now
Earths slowdown is due to a transfer discrepancy, they suggest, may be due to
William Chen and colleagues from
of rotational momentum to the moon; melting glaciers or fluxes in the deepest
the University of Pittsburgh have
it also gives the Moon a little thrust, layers of the Earth, which mitigate the
traced its secret, as reported in
speeding up its orbit and causing it to forces contributing to the slowing of the
Science Advances last November.
recede from Earth by about 4 cm per year. planets spin.
It lies not with the heart cells but
the scaffolding that supports them,
known as extracellular matrix (ECM).
Mice that suffered heart attacks
made a remarkable recovery once
injected with a powder of zebrafish
heart ECM. Normally, mouse heart
cells rarely multiply, but they kicked
in, repopulating the damaged heart
muscle and restoring its elasticity.
Some of the powders properties
appear attributable to neuregulin-1
and ErbB2, proteins which regulate
cell proliferation.
The powder also stimulated
human heart cells growing in a dish
to proliferate. The authors are now
testing to see if the zebrafish powder
can mend the hearts of larger animals.
The Moons pull is slowing the Earths orbit, but not as much as the maths predicts.
CREDIT: NASA / DSCOVR EPIC TEAM
COSMOS DIGEST 15
A close-up view of the first intact feathered dinosaur tail ever to be found.
CREDIT: ROYAL SASKATCHEWAN MUSEUM / R.C. MCKELLAR
glimpse into how dealer. Xing and his team described the
find in Current Biology in December.
lacked the well-developed central shaft,
or rachis, found in feathers used in flight.
feathers evolved The tail was flexible, with eight That supports the theory that animals
articulated vertebrae. This ruled out the first developed feathers not to fly but
possibility that it belonged to an ancestor perhaps for camouflage, or attracting
The amber-encased specimen is the
of birds, whose tail vertebrae, like those mates.
first confirmed to be from a dino.
APRIL REESE reports.
TECHNOPHILE
The eyes have it: by bouncing near-infrared light (so you
cant see it) off your eyes to detect your
treatment, saving a huge amount of
processing power.
looking to the future pupils and work out where youre looking. Tobii rival Oculus sells similar
Its not pixel-perfect. At best, devices technology to the EyeX geared more
such as these can pinpoint where on the for commercial use. Its system, recently
Soon well all have powerful looks.
screen youre looking to an accuracy of purchased from Danish company Eye
By CATHAL OCONNELL .
about one centimetre. If typing, you could Tribe, can analyse how people navigate
highlight a particular word but not a single websites, generating a heatmap showing
I did it with my eyes, Matilda said. I was letter; and to achieve even that level of how the eyes scoot around from pictures to
staring at [the glass] and wishing it to tip and accuracy, new users must go through a text and, of course, adverts.
then my eyes went all hot and funny and some labourious series of calibration steps to The technology can also interface with
sort of power came out of them enable the device to follow their eyes. the front-facing camera on a smartphone
Bullings team, along with researchers or tablet to monitor your gaze. You could
Who hasnt daydreamed about moving at Lancaster University hope to ease that set up the device to automatically scroll
things with their eyes, like the young burden. They developed software that down a web page as your eyes approach the
heroine in Roald Dahls novel Matilda rapidly and automatically calibrates to bottom of the screen. Or you could pause
discovered she could do? Soon, we could new users by observing how the users eyes or rewind a video with your eyes useful
all possess that magical power at least pursue a series of moving targets. for following a recipe with your hands full
when it comes to our digital devices. A more challenging issue with existing in the kitchen. The software could soon
New advances in eye-tracking eye-tracking technologies, Bulling says, add to the simple head-tracking features
technology mean controlling computers is the so-called Midas touch problem. already creeping onto smartphones such
and smartphones with our eyes Our eyes naturally jump around as we as the Samsung Galaxy, which can auto-
could become as routine as tapping a continually scan our environment, pause a video when you look away from
touchscreen is today. meaning eye-trackers can pick up the screen.
As futuristic as it sounds, digital unintended commands. Holding down The technologys most life-changing
technology to track gaze has been around a designated key is one way to let the uses, though, will be in health care, where
since the 1990s, but the bulkiness and cost device know when to pay attention, eye-tracking is already beginning to help
of the equipment limited its use to niche though that limits the technologys people with disabilities control computers,
research applications. Psychologists used hands-free appeal. and could soon enable them to operate
it to study eye movement during reading, Despite the limitations, there is plenty their own wheelchair.
for example, or how a persons eyes scan early adopters can do with todays devices. It may not be Matildas mystical
a new face. Supermarket chains and other Combined with keyboard clicks, they are power, but thats still pretty magical.
stores employed it to check out what good enough to control a web browser,
ILLUSTRATION: ANTHONY CALVERT
products catch a customers eye as they for example, and play games.
scan shelves. Tobii markets the EyeX primarily
Now the technology has advanced as a gaming accessory. Some of the latest
enough to be used on a home computer. games promise an immersive experience,
The latest generation eye-tracking detecting where you are looking and EYEX SPECIFICATIONS
technology is not only much cheaper, panning the view in that direction. You can SIZE: 32 x 2 x 1.5 centimetre
but considerably smaller, says Andreas even use your eyes to target your weapon. sensor bar
Bulling, a technology researcher at the The EyeXs gaming emphasis isnt WEIGHT: 90 grams
Max Planck Institute for Informatics in surprising when you consider that much SENSORS: Three infrared sensors
Saarbrcken, Germany. of the recent progress in eye-tracker PRICE: US$139
Take EyeX, a device that allows you technology was fuelled by research into
to move your mouse cursor around using virtual reality and augmented reality OCULUS SPECIFICATIONS
your eyes. Created by Swedish company headsets (Cosmos issue 62 p32; issue 67, SIZE: 20 1.9 1.9 centimetre
Tobii, this eye-mouse is a thin black p26). By tracking your eyes, VR devices sensor bar
bar, about the length of a ruler, placed just can figure out which parts of a scene WEIGHT: 70 grams
below your computer screen. The device, they should render in high resolution. PRICE: US$199
costing just 109 (about A$145), works The background only needs a cursory
COSMOS DIGEST 17
HEAD-TRACKING
To gain even more
information from the
user, some systems
also monitor where
the head is pointing.
Combined with signals
from the eyes, turning a
wheelchair could become
as simple as looking to
the left or right.
18 DIGEST Issue 73
BROUGHT
TO YOU BY
UNIVERSITY OF
NEW ENGLAND
FROM
THE
FRONT
LINE
The faces of remote
sensing innovation
A unique combination of research expertise PARG, established in 2002, offers Muhammad Moshiur Rahman, Jasmine Muir
and strong industry engagement puts a cutting-edge research and learning and Andrew Robson prepare a sensing
university research team at the global that supports the development and drone. CREDIT: THE UNIVERSITY OF NEW ENGLAND
cutting edge of agricultural innovation. implementation of modern technologies
ANGUS BEZZINA reports . such as satellite and ground-based remote
sensing, geographic information systems, and projected yield. The implications
Andrew Robson, Muhammad Moshiur sensor networks and livestock tracking. of this research are relevant to all
Rahman and Jasmine Muir. Remember Its mandate is to evaluate technologies agricultural commodities, both in
these names, because they belong to three and practices that benefit the agriculture Australia and abroad.
very talented scientists who form the core sector and to work with industry partners Before joining the UNE PARG
of the Agricultural Remote Sensing Team to see them implemented appropriately. group three years ago, Robson started
(ARST) within the University of New his agricultural career picking oranges
Englands Precision Agricultural Research in the Riverina, before being employed
GROWERS CAN OPEN A COMPUTER
Group (PARG). by the Queensland and New South
OR SMARTPHONE FROM ANYWHERE
The trio, with support from other Wales departments of primary industry
IN THE WORLD AND MONITOR CROPS.
PARG members David Lamb, Derek for nearly 20 years. The majority of his
Schneider and Ashley Saint, have research has focused on the development
established themselves as the leading Remote sensing is a key technology of remote sensing applications specific
agricultural remote sensing group in for PARG and ARST. It allows growers to agriculture.
Australia. The team currently leads or to assess crop performance without Rahman joined the group in 2015
collaborates in remote sensing projects physically making contact with it. after completing a doctorate in precision
that span nine Australian agricultural Essentially, it means growers can open agriculture at UNE. Before settling
industries (sugar, rice, avocado, mango, a computer or smartphone from anywhere in NSW, he had completed a Masters
macadamia, banana, peanut, pineapple in the world and monitor crops, assess degrees in farm power and machinery
and multiple vegetable crops). pests and diseases, nutrient levels in Bangladesh and agricultural and
COSMOS DIGEST 19
VIEWPOINT
BODY TALK
ASTRO KATIE
PHILOSOPHERS
CORNER
ORIGINS
HOLODECK:
COMPILED BY JAMES MITCHELL CROW
LESSONS
FROM MARS
GRAVITY MAP
Mars is pockmarked by towering mountains such
as Olympus Mons three times the height of
Mount Everest and craters 9 km deep. The mass
differences in the crust mean spacecraft experience
tiny changes in gravitational tug as they orbit Mars.
These wobbles are measurable and can be used
to calculate the changing gravity and mass. For
instance, they revealed that the mass of the CO2
icecaps varies seasonally by 4 trillion tons.
Scientists pooled measurements from three
orbiters to build this gravity map of the planet
in 2016. Low-gravity canyons like Valles Marineris
in blue (centre) stand out from the high-gravity reds
and whites of Tharsis Montes, the three aligned
volcanoes left of centre and Olympus Mons, above
and left. This gravity map will help future craft chart
their orbit with greater precision.
CREDIT: NASAS SCIENTIFIC VISUALIZATION STUDIO
34 COVER STORY Issue 73
01
SKA will not only take us to
the edge of the universe, it will
revolutionise computing.
COSMOS COVER STORY 35
THE
BIG DATA
TELESCOPE
NEXT-GENERATION TELESCOPES usually aim us to hear the whispers of newborn stars against the
to double the performance of their predecessors. cacophony of the universe doesnt involve grinding
The Australian arm of SKA will deliver a 168-fold mirrors to atom-thin smoothness or constructing
leap on the best technology available today, to dishes the size of sports fields. The disruptive
show us the universe as never before. It will tune technology here is supercomputing.
into signals emitted just a million years after the Once SKA-low is running, it will generate more
Big Bang, when the universe was a sea of hydrogen data every day than the worlds internet traffic.
gas, slowly percolating with the first galaxies. Dealing with this deluge is a challenge being tackled
Their starlight illuminated the fledgling universe by hefty global collaborations of academia and
in what is referred to as the cosmic dawn. private enterprise and it is by no means clear how
It is the last non-understood event in the it will be solved. Its a scale no one has attempted
history of the universe, says Stuart Wyithe, before, says Peter Quinn, a computational
a theoretical astrophysicist at the University of astrophysicist at the University of Western
Melbourne in Australia. Australia, and director of the International Centre
Like any dream, realisation is the hard part. for Radioastronomy Research (ICRAR) in Perth.
In 2018, when the first of 130,000 Christmas- While international mega-science projects
tree-like antennae is deployed on the sandy plains have been tackled before think the European
of Murchison, an almost uninhabited district of Organisation for Nuclear Research (CERN), which
50,000 square kilometres, it will mark 28 years operates the worlds largest particle accelerator, the
since its conception. Large Hadron Collider when it comes to the SKA,
Epic battles have brought the project to this the potential world-changing spin-offs have never
point most famously the six-year contest between been so blazingly obvious.
countries to host the telescope. Australia and CERN didnt just find the Higgs boson
South Africa ended up sharing the prize. The SKAs computer scientist Tim Berners-Lee created
telescope in South Africa will be built on another the World Wide Web to manage its information
flat, red flat plain the Karoo region of the North sharing. Wi-Fi was the spin-off when Australian
Cape. It has somewhat less lofty ambitions its CSIRO astronomers developed ways to realign
dishes will probe only halfway to the edge of the scrambled radio signals from black holes.
universe. Its moniker, SKA-mid, denotes the mid- Mega-corporations such as CISCO, Woodside,
range frequencies of radio waves stretched across Chevron, Rio Tinto and Google are already
this distance. positioned to collaborate with SKA astronomers
Australias SKA-low, by contrast, will tune into around the world.
the low frequencies emanating from the extremities A science project of this grandeur, managed
of the cosmos. Together the two telescopes will across 10 countries, involving dozens of specialist
represent the largest science facility on the planet, technical consortia and thousands of people, is
says SKA director-general and radio astronomer challenging enough. The question of how to divvy
Phil Diamond, who is based at Jodrell Bank up the pie for construction contracts and the
Observatory in the UK. commercial spin-offs that follow adds a whole new,
The game-changing technology that will allow complicated layer.
COSMOS COVER STORY 37
02
IT WILL
GENERATE
MORE DATA
EVERY DAY
THAN THE
WORLDS
INTERNET
TRAFFIC.
The 200 dishes of SKA-mid to be rolled out in South Africa will probe half way
to the edge of the universe. (Artists impression)
Nevertheless, as the gears of the vast project sea of it. Today, things are different the sea
slowly grind into action, Australia is bracing to host is dotted with galaxies. But how did these
its first global mega-science project. It will be our galactic islands form? To find out requires a
CERN downunder, says CSIRO astronomer Sarah telescope that can look back to the rippling
Pearce, Australias science representative to the hydrogen sea of 13 billion years ago. Thats
SKA board. But, she adds, dont expect a tour. Its why the SKA was originally called the hydrogen
here precisely because there are very few people. telescope, Quinn says.
38 COVER STORY Issue 73
Those who imagined the SKA had a lust for How does a forest of radio antennae figure
hydrogen. Their appetite had been whet by the Very out where in the sky a signal has come from?
Large Array (VLA), 27 dishes lying 80km west of Interferometry, a technique developed by British
Socorro, in New Mexico. and Australian radio astronomers in the 1940s, is
Now known as the Jansky VLA, the telescope the key. It relies on the principle that each antenna
generated some of the first detailed maps of atomic in an array receives a signal at a slightly different
hydrogen. The bond between hydrogens electron time. For instance, radio waves coming from
and proton emits a unique 21-centimetre radio the easterly part of the sky hit the eastern-most
wave. Because the universe is expanding, the waves antennae earlier than those lying further west.
emitted from outer space have stretched by the By electronically tweaking the delay on each, the
time they reach us. The futher away, the greater entire forest could be made to point in a particular
the stretching; hydrogen waves emanating from direction of the sky.
the edge of the universe measure 1.5m by the time But using interferometry to tune into signals
they reach Earth. Its known as the Doppler effect; from the edge of the universe would have required
on Earth, we experience it when we hear the sound filtering astronomical amounts of data; and that was
ALGORITHMS of an ambulance siren deepen as it speeds away, its a challenge yet to be mastered.
DEVELOPED sound wave stretching as it goes.
In 1990, on the 10th anniversary of the VLA, the
TO PURSUE worlds radio astronomers met to celebrate one of THE TUSSLE
SKAS GOALS the New Mexico facilitys crowning achievements
mapping hydrogen in nearby galaxies. Ron Ekers, In 2000, a SKA steering committee led by Ekers
MAY BE THE an Australian former director of the array, recalls invited proposals for a home for the telescope.
NEXT WI-FI. that everyone was on a high. Five countries responded. To help their bid, some
Not content to rest on their laurels, a small built serious prototypes known as pathfinders.
group of visionary astronomers wondered how far It resulted in an astronomical bonanza. Australia
the technology could be pushed. Egged on, Peter built the majestic dishes of the Australian Square
Wilkinson from the University of Manchester in Kilometre Array Pathfinder (ASKAP) and the
Britain pitched the idea of reaching out to galaxies antenna forest of the Murchison Widefield Array
at the edge of the universe. A total collecting area of (MWA). South Africa built the seven dishes of
one square kilometre, he figured, should do the job. KAT-7 and is building the larger MeerKAT. China
The audacity of the proposal was amazing, began work on a prototype which paved the way for
Quinn says: Most telescope improvements aim the Five-hundred-metre Aperture Spherical radio
for a two-to-three-fold increase; this proposal Telescope (FAST), the largest single radio dish in
represented a 10,000-fold increase. That figure the world.
reflected a 50-fold increase in sensitivity multiplied Geography worked against some of the
by a 200-fold increase in field of view. The goal contestants. The Chinese site wasnt flat enough.
was to see a milky way at the edge of the universe, The joint Brazilian-Argentinian bid was let down by
Quinn adds and to scour the entire southern sky. a turbulent ionosphere the uppermost layer of the
The breakthrough technology needed to enable atmosphere which distorted the sought-after low
this leap did not lie in fancy new telescope designs, frequency radio waves.
but in the explosion of computing power and By 2006, Australia and South Africa were
techniques able to handle massive amounts of data. the last countries standing. Both laid claim to
The receivers themselves could be little more vast unpopulated regions, free of radio wave
than antennas. Tuned to radio wavelengths, they interference and with relatively placid ionospheres.
would pick up the extra-long waves of distant The South African sites higher elevation was
hydrogen coincidentally the same wavelength in its favour. Australia, on the other hand, had an
used by many FM radio stations. This is where the impressive track record in radio astronomy. It
early universe is broadcasting, says Quinn. You boasted some of the worlds first interferometers,
just cant hear it because its buried in the crackle. built in the 1940s at Dover Heights south of Sydney,
The more antennae, the greater the sensitivity and the iconic CSIRO Parkes telescope, operating
hence the planned one square kilometre of since 1961.
collecting surface. But the antennae dont need to The contest was fierce, and for good reason:
be all in one spot. Indeed, the more spread out they SKAs benefits clearly stretched far beyond
are, the sharper the focus. astronomy. The devices and algorithms developed
COSMOS COVER STORY 39
03
Like a forest of metal pine trees:
an artists impression of some of
the 130,000 antennae of SKA-low
to be assembled on the red plains
of Murchison. They will probe to
the edge of the universe.
40 COVER STORY Issue 73
350 MH z
14 GH z
frequency range
DATA
STATS
150
2
kilometres
200 distance between dishes
Number of dishes
terabytes of raw data
(Including MeerKAT
per second.
dishes already
340,000
operational)
50 mH z
350 MH z 130,000
frequency range
Number of antennas.
They will be spread
across 500 stations.
65 kilometres
the distance between
each station
DATA
STATS
157
terabytes of raw data
per second.
27 million
Number of average laptops filled
with content every day.
42 COVER STORY Issue 73
to pursue SKAs goals may be the next Wi-Fi, the in mid-2013. According to director Randall Wayth,
next multi-trillion dollar technology market, it has blazed the trail for SKA-low. It is tuned to
says Steven Tingay, the former director of the receive signals from the early universe within the
MWA who now leads Italys SKA involvement. bandwidth of 60 to 250 MHz. It does not have the
Whichever country hosted the SKA would be at the sensitivity to detect features of the cosmic dawn,
heart of the action, attracting and training the next but its impressive 30-degree field of view allows it
generation of engineers and scientists in advanced to map the entire visible sky over a few nights. The
manufacturing, telecommunications and high- Galactic and Extragalactic All-sky MWA (GLEAM)
performance computing. survey, for instance, mapped bubbles of ionised
Accompanied by the sort of media attention hydrogen gas and quasars from up to six billion light
usually reserved for a football grand final, a years away.
competitive and secretive bidding process ensued. Two trail-blazing aspects of its operation are
In May 2012, members of the SKA organisation key to SKA-low. The first is that it has pioneered
voted to split the array between the Australian and methods to adjust for the distorting effects of the
African sites. The South African telescope would ionosphere above Murchison. Its like trying to
WE BELIEVE observe radio waves from 350 MHz to 14 gigahertz, see something at the bottom of a rippling pool,
WE KNOW enabling it to detect signals up to six billion light- explains Wayth. Luckily for us, its usually just
years away a still sparse chapter in the universes small ripples.
HOW TO DO life story. It would use dishes like those of the JVLA, Filtering out the ripples of the ionosphere is
IT, BUT IM but dramatically increase speed and sensitivity. just one step in a multipronged data-processing
Australias array would detect frequencies in operation whose ultimate aim is to deliver sharp
NOT HIDING the range of 50 to 350 MHz ideal for detecting images of the ancient universe.
THE FACT hydrogen signals from the edge of the universe. Another early step reduces the noise inherent in
Both would rely on the development of the system. The heart of every radio telescope is an
THAT ITS A disruptive new computation techniques. onsite computer known as a correlator. Developed
CHALLENGE. We believe we know how to do it, but Im not through a partnership with IBM and Cisco, the
hiding the fact that its a challenge, Diamond says. MWAs correlator compares signals from each of
the 2,048 antennae. Noise is random; real signals
are correlated. By accepting only correlated signals,
BUILDING IT this step reduces the data to a manageable 1% of the
initial deluge.
Getting to the Australian site of the SKA gives The next phase takes place off-site. An 800 km
the words isolation and quiet whole new optic fibre ferries the pre-filtered data from the
meanings. First, you make your way to Perth, itself desert to the Pawsey Supercomputing Centre in
one of the most isolated cities in the world. Then its Perth. A mirror link also takes it to collaborators
another one-hour flight to the 35,000-strong port at the Massachusetts Institute of Technology in
town of Geraldton. From there, bump around for Boston, and Victoria University of Wellington
four dusty hours in a four-wheel-drive until finally, in New Zealand, to be used by some 35 different
on the horizon, you see a succession of towering science projects.
white 12-metre telescope dishes. Just as a human brain must process vast
You have arrived at the Murchison Radio- amounts of data into a meaningful representation
astronomy Observatory. The 36 dishes comprise of the world, these supercomputers turn the MWA
ASKAP. Despite the name, they are not the radio wave signals into pictures of the universe.
prototype for SKA-low. That honour goes to the There are data from across different regions of the
MWA, a rather less majestic affair that lies hidden sky, and across tens of thousands of frequencies.
in the nearby mulga scrub: 2,048 squat, wiry It is sifted by setting windows to extract cubes of
antennae, resembling a swarm of giant spiders. information. Like pixels on a screen, they provide
Unlike ASKAP, the MWA has no moving parts to an image of the universe.
point to different parts of the sky. Thats because The MWAs coarse resolution means its cubes
this is a software telescope. It relies on a computer cant produce a sharp image. SKA, with its 100-
to program different delays into the antennae so fold greater sensitivity and 40-fold increase in
signals from the same patch of sky are collected resolution, will provide more cubes to show us what
at the same time. is actually there. But in order to do that, it must
Amid great fanfare, MWA first came online solve the data deluge problem.
COSMOS COVER STORY 43
A TWO DIFFERENT
CLOSER
LOOK TELESCOPES
RADIO TELESCOPE DISH
The aperture array can trace the source By introducing different electronic
of a signal by measuring the delay with delays at each antenna, they can be
which it arrived at each antenna. focused on the same part of the sky.
Interferometer
Signals arrive at different times All signals arrive at the same time
44 COVER STORY Issue 73
04
The Murchison Widefield Array is the prototype for the SKA-low. This image from the GLEAM
survey shows how the Milky Way appears at radio wavelengths.
05
The antenna design selected for SKA is not The computational challenges of the SKA are
the MWAs squat spider, but one that formidable; so too are those involved in building
resembles a pine tree the so-called log periodic and rolling out the infrastructure in the middle
design. Different rung lengths on the tree enable of the Australian outback. Its a perfect job for
it to resonate in a wide range of frequencies a former army tank officer.
from 50 to 650 MHz. (MWA typically manages Tom Booler has been project manager for
60 to 250 MHz.) SKA will deploy 130,000 the MWA and part of the SKA-low team since
of them. 2011. His mission is to plan the construction and
But that wont deliver the eponymous square deployment of 130,000 antennas in the desert
kilometre of collecting area. The 650 million absent a local workforce, with no construction
(about US$690 million) funding for phase 1 will equipment and no power grid. And thats only the
only deliver four-tenths of that. Nevertheless, it first phase of SKA-low. The second, slated for the
should have the sensitivity to detect primordial mid-2020s pending funding, will see the number
galaxies across large patches of sky. of antennas swell to about a million. The scale,
The first phase of SKA-low will churn out cost and remoteness of the site make it one of the
raw data at a daily rate greater than the worlds toughest science projects ever undertaken.
internet traffic; impossible to store, or for human Supplying power is a major hurdle. The MWA
minds to process in real time. Ingenious algorithms is powered by a 1.6 MW hybrid solar-diesel power
will be needed to sift valuable nuggets from the station, parts of which must be shielded to stop the
deluge. radio waves it creates from interfering with the
THE WORLD
The University of Cambridge leads a consortium telescope. Phase 1 of SKA-low will need 2.25 MW. WIDE WEB
of 23 organisations, including Perths ICRAR, Phase 2 will need the power supply of a small city.
to develop new hardware and software systems Extreme weather also has to be factored in.
DEVELOPED
for the task. One of ICRARs major software In 2015, nearby Milly Milly Station bore a years BY CERN
contributions goes by the name DALiuGE an worth of rain in five months. While cattle grazers
acronym for data activated logical graph engine. welcomed it, road closures disrupted plans at the
CHANGED
Its also a bilingual play on the word deluge: liu observatory. Besides sudden downpours, Booler THE WORLD
is a Chinese character meaning flow. also has to reckon with temperatures soaring over
Last June, an ICRAR team successfully ran 40 C in the summer months and then theres the
FOREVER.
the prototype of DALiuGE on the second-most desert death adder. I SUSPECT
powerful supercomputer in the world, Tianhe-2, But one thing the shire of Murchison has going
in Guangzhou, China. Next, the team hopes to for it and a reason it won the bid for the SKA
THE SKA WILL
test it on the most powerful, Sunway TaihuLight is the quiet. Population density is extremely low DO THE SAME.
in Wuxi, eastern China. just 115 people spread over an area the size of the
The computing challenges may be huge, but Netherlands. There are no mobile phone towers or
its not the first time the global community has radio and television transmitters. The shire is also
taken on something so big. To solve CERNs hushed by regulations enforced by the Australian
problem of distributed processing and information Communications and Media Authority.
sharing, its researchers ended up developing Within the observatory, every appliance
the World Wide Web. That changed our world gets stripped of wi-fi hardware before it arrives.
forever, Quinn says. I suspect the SKA will do The observatory control centre, which houses
the same. computers that crunch data from the existing
SKAs rewards are already reaching beyond telescopes, is the radio equivalent of an airlock, with
science into industry. Besides CISCO and IBM, radio-wave-proof double doors and no windows.
other big-name collaborators on the project Inside a radius of 70km around the observatory
include British-Australian mining giant Rio Tinto, authorities can order mobile phones be turned off.
international gas and oil company Chevron, Out to 260km emissions are regulated in key radio
Amazon and Intel. All are highly attuned to new frequency ranges.
ways of solving their big data problems whether The entire area is more than six times bigger
it is crunching data to make images of oil, gas and than the US National Radio Quiet Zone, home to
mineral deposits below the ground, or finding the Green Bank radio telescope and a population
patterns in vast databases. running into hundreds of thousands.
46 COVER STORY Issue 73
BACK TO
THE COSMIC
DAWN
WE KNOW SOMETHING of the first few hydrogen gas disappeared, reionised into a
moments after the violent birth of our plasma of protons and electrons. The era is
universe. A split second after the Big known as the epoch of reionisation.
Bang, it was a tiny mushrooming fireball, How did this happen? It turns out
10 billion degrees hot and filled with a there are lots of theories, and they are
plasma of frenetic charged particles. almost completely unconstrained by data.
Over the next 380,000 years, the Traces of dark matter laid down
expanding universe cooled. Charged in the Big Bang, slightly denser than
particles electrons and protons their surrounds, may have triggered
lost enough of their youthful energy the snowballing of hydrogen into stars.
to bond with each other and form the But why did the intergalactic hydrogen
first hydrogen atoms. In this more staid disappear?
universe, light from the Big Bang could The leading theory is ultraviolet
at last move in uninterrupted straight radiation from the first hot stars stripped
lines. As space continued to expand, the the surrounding hydrogen of its electrons.
Swiss cheese model of ancient universe:
light waves stretched to the length of But there is another contender: quasars.
neutral hydroden (red), reionised hydrogen
microwaves which we see today as the Quasars (quasi-stellar radio sources) are
(holes), galaxies (white). CREDIT: STUART WYITHE
cosmic microwave background. among the brightest and oldest objects
This much we know. The next episode in the universe. They are powered by
remains a mystery. black holes; the source of their light is the possibility is that it was quasars that
At 380,000 years old, the universe radiation emitted by accelerating gases reionised the universe, says astrophysicist
was a peaceful sea of hydrogen. A billion as they are sucked towards the accretion Stuart Wyithe, at the University of
years later, most of it was gone. We know disc. Quasars can be surprisingly ancient, Melbourne, who specialises in trying
a small percentage snowballed under appearing just 770 million years after the to recreate this unknown period of the
the influence of gravity to form stars and Big Bang. history of the universe. The theory also
galaxies. But the vast intergalactic sea of Its controversial, but one exciting suggests that massive black holes may
COSMOS COVER STORY 47
FINAL STRETCH
CAN CRISPR
SAVE
BEN DUPREE?
01
50 FEATURE Issue 73
DOCTORS SAY THE DISEASE is terminal, but they the hospital had modified Duprees cells in a dish,
tell you less about living with it. About the girls cutting through the extra exon. The editing process
who dont see past your wheelchair, or how the required only a single step and had taken three days.
phone stops ringing. Its you and Mum counting the In an image taken with a microscope, Duprees
birthdays and figuring out what you cant do this cells were clouded with green puffs of perfect
year. Dupree says he got by in high school, but in dystrophin.
college depression gripped him. I didnt know I try to be realistic with my expectations,
how I could keep going, he says. he says. But that gave me a sense of, Wow, this
The problem is that Duprees body doesnt is here.
make dystrophin, a protein in muscle fibres that The potential to precisely and easily edit
acts like a shock absorber. Without it, your biceps, any genome using CRISPR is changing the way
calf muscles and diaphragm slowly turn to a fat-like we think about nature. The CRISPR technique is
substance. You end up on a ventilator, and then your often likened to a search and replace function
heart stops. for DNA. To laboratory scientists, it might better
Dystrophin is manufactured by a gene that be compared to the discovery of fire. Every day
is among the largest in the human genome. It they publish an average of eight scientific articles
consists of 79 components known as exons, each describing new uses of the technology or
an instruction for one ingredient of the protein. merely reflecting on its exponentially expanding
Duprees problem, he says, is a pseudo exon possibilities, such as designer babies engineered
as though in the middle of this epic recipe someone with desirable traits and mosquitoes with DNA
added an instruction that read: Stop the cooking. programmed to make them go extinct.
There are thousands of ways a gene this size can go Among these possibilities, the chance to end
wrong, and Duprees mutation a single letter of the pain and suffering of people like Dupree is
DNA that reads G instead of T is unique, CRISPRs most compelling, if still distant, promise.
so far as scientists know. In early-stage lab experiments, academic scientists
Dupree, who majored in biochemistry and hopes are showing that gene editing offers new ways
to become a genetic counsellor, has sometimes to attack cancer, to knock out HIV and hepatitis
imagined what life would be like if that small error infections, even to reverse blindness and deafness.
were not there. Companies arent far behind. Three startups in the
A year ago, in December 2015, he learnt Boston area have already raised a combined
how a technology called CRISPR might make US$1 billion and partnered with some of the
that possible. A scientist named Eric Olson had worlds biggest drug companies such as Bayer and
requested some of Duprees blood a few months Novartis. None of us can anticipate where this
earlier, and Dupree had agreed. Soon he was rolling technology will end up, says Olson. Im operating
through the lab on his TiLite wheelchair so Olson, under the premise that it will take us farther than
a biologist at the University of Texas Southwestern we can imagine.
Medical Centre, could show him the results and Scientists know the gene errors responsible for
what some scientists now predict is the likeliest way about 5,000 inherited disorders and sequencing
to cure Duchenne. labs discover some 300 more each year. Some
Using CRISPR, which makes it possible to snip are one-in-a-billion syndromes. Duchenne is at
DNA open at a precisely chosen spot, a team at the other extreme; it is one of the most common
COSMOS FEATURE 51
inherited diseases, affecting 1 in 4,000 boys. Girls Olson says the very first human test of a CRISPR
are affected rarely and to a lesser degree. therapy in a patient with Duchenne could begin
Gene editing could be a way to erase such in two years in what would be a small, exploratory
diseases with a one-time, permanent alteration of a clinical trial involving just a few boys. Working with
persons DNA. Its a step beyond conventional gene Jerry Mendell of Nationwide Childrens Hospital in
therapy the 30-year-old idea of inserting entire Ohio, a centre for gene-therapy studies, they expect
replacement genes into a persons cells, usually to give the treatment to monkeys during the next 12
using a virus. That approach is impractical for some months, a prelude to human tests. The researchers
diseases. The gene for dystrophin, for instance, is will also be looking to see whether the CRISPR gene
too large to fit inside a virus, as CRISPRs DNA- therapy has unexpected effects. Accidental edits are
snipping proteins can. Sometimes a faulty gene a particular concern.
thats doing harm needs to be silenced, so adding a Dupree, who is following events in the lab, says
new one wont help. CRISPRs ability to delete and hes not expecting much for himself. He knows
swap out genetic letters makes a huge new range of the studies could take years and since his mutation
treatments possible. is unique, hed need a therapy tailored just for
02
I AM MORE
EXCITED
ABOUT THE
IMPLICATIONS
SCIENTIFICALLY
THAN ANY
TREATMENT
FOR ME
Wheelchair bound Ben Dupree is cautiously hoping that the results being cooked up in the lab
will one day help him.
Some doctors are now calling CRISPR gene him. I am more excited about the implications
therapy 2.0. To be sure, even gene therapy 1.0 scientifically than any treatment for me, he says.
has yet to fully arrive. After 30 years of research, But his mother, Debbie Dupree, says chat boards
scientists are still learning how to use viruses to and Facebook pages where parents gather are
move genetic instructions into a living persons already alight with questions. There is a lot of
cells. Only two gene-replacement treatments for talk. People want to know when it will be available,
inherited disease have ever been approved, both she says.
in Europe. Duchenne patients and their families wont
But Olson says he is convinced CRISPR is the be the only ones anxiously asking that question.
most plausible way to stop Duchenne. Early this Countless others facing deadly cancers or HIV,
year, he showed he could repair mutations in mice as well as sickle-cell anemia and numerous other
with muscular dystrophy after sending viruses genetic diseases, could soon be watching the fate of
stuffed with CRISPR ingredients into their veins. those CRISPR-altered cells in Olsons lab. Are they
A mouse is not a boy, but we think we know exactly the beginning of a new era of medicine or merely
what needs to be done, Olson says. If it works, he one more promising research result that will never
adds, this is a cure, not a treatment. make it out of the lab? In particular, researchers
52 FEATURE Issue 73
will need to solve the next challenge: safely Just as bacteria spot and slice the viral genetic
and effectively editing DNA in cells throughout material, CRISPR can zero in on specific stretches
a human body, thus turning CRISPR from an of human DNA. The only ingredients needed are
invaluable lab tool into a medical cure. an editing enzyme one named Cas9 is used most
often and a short guide, or length of genetic
CRISPR EVOLVED INSIDE BACTERIA , over billion- letters, to tell it where to cut.
year time scales, as a form of immunity against
viruses. Bacteria collect and store short snippets of 03
DNA from viruses that have invaded them, spacing
the segments out through their own genome in
a pattern called clustered regularly interspaced
short palindromic repeats the term that gives
CRISPR its acronym. When reinfected with one
of these viruses, bacteria can create copies of these
genetic snippets, which zip up letter for letter with
the new viruss DNA signalling to a specialised
cutting enzyme that it should attach itself and close,
pincer-like, onto the viral genome and sever it.
By 2013, teams of scientists in Boston, Berkeley
and Seoul separately showed this naturally
occurring bacterial immune process could be
simplified and repurposed to cut DNA in human
cells. Though scientists had previously created
gene-editing proteins, these were difficult to design
and build compared with the solution bacteria had A virtuoso gene editor: CRISPR-Cas9 (3d model)
devised. Instead of version 2 or version 3, it was at work on a strand of DNA.
version 3 trillion, says Tom Barnes, chief scientist
of the CRISPR startup Intellia Therapeutics in It seems simple, but using it to create human
Cambridge, Massachusetts. It went from no labs treatments is anything but. And theres one
working on it to everyone working on it. hitch thats often overlooked: editing is a bit
Intellia is one of a trio of startups that have set of a misnomer. Scientists have mastered cutting
up shop around Boston and raised about into DNA, which gives them something akin to
US$300 million each to create CRISPR treatments; a delete key for genes, in addition to the add
the others are Editas Medicine and CRISPR function offered by traditional gene therapy. But
Therapeutics. Barnes says CRISPR vastly simplifies they cant as easily rewrite genes letter for letter,
gene editing because of the way the cutting works. an aspect of the technology still being developed.
For now, that mostly limits them to situations company has opened a study to create supercharged
where deleting genes, or parts of them, is useful. immune cells to battle cancer, and scientists at the
Duchenne is one of those. Another is sickle-cell University of Pennsylvania have announced similar
disease, a condition that in the United States affects plans with the financial backing of the billionaire
mostly African-Americans. Medical researchers internet entrepreneur Sean Parker.
have given it relatively little attention in the past, If youre looking for gene editings Everest, its
but theres an obvious DNA cut that might solve it, probably rewriting DNA in the human brain say,
meaning a potentially elegant cure. to treat Huntingtons disease. Editing muscle cells
Now Mitchell Weiss, a haematologist who treats lies somewhere in the middle of the difficulty scale.
people with sickle-cell at St. Jude Childrens Genetically, its a good candidate. Even with just
Research Hospital in Memphis, says every a delete key, Olson says, up to 80% of muscular
gene-editing company is calling him. The interest dystrophy cases could be treated. Initially, the
right now is incredible, he says. Before, no one editing treatment hes working on will target a hot
was interested. No one cared. But they need a proof spot in the dystrophin gene exon 51, in which
of principle, and this is a good one. Editas has also signalled an interest. Deleting that
In addition to finding the kind of genetic exon could treat about 13% of Duchenne cases.
problem to which CRISPR offers a solution, The most significant unknown is whether it will
companies need a way to get the CRISPR be possible to edit enough muscle cells and make
instructions into the body. Most are counting on enough dystrophin in a human body. I think this
viruses for that job, but Intellias strategy is to represents the most promising strategy, Olson
package CRISPR into fatty blobs that liver cells says. But the thing that has to go right is that it has
suck up, just as if they were cholesterol. In August to be efficient. Muscles, including the heart, glutes,
2016, at the annual CRISPR meeting in Cold Spring and biceps, make up 40% of a persons body mass
Harbor, New York, researchers from the company billions and billions of cells. So far, in his mice,
showed that a single dose could alter the genomes of Olson has succeeded in producing dystrophin in
at least half the cells in a mouses liver. If Intellia can 5-25% of muscle fibres. Its half calculation and half
successfully edit liver cells in a person, that may let speculation, but he thinks that editing 15% of the
the company treat a slew of previously unassailable muscle cells in a boy will be enough to slow, if not
metabolic conditions like a form of hereditary halt, muscular dystrophy.
amyloidosis, in which painful plaques build up in When I last spoke to Olson, he was rushing to
the body. a phone meeting to drum up commercial support
Whats obvious is that it will be easier to get for his idea of starting a human test for a Duchenne
CRISPR to work in some parts of the body than treatment. He has been talking with several
others. The easiest task is probably deleting genes companies including Editas, probably the
in blood cells, since these cells can be removed from best-known of Bostons trio of CRISPR startups.
a patient and then put back. Already, a Chinese drug It has Bill Gates and Google as investors.
US biotechnology firm Scientists in the US and Adding CRISPR to muscle Chinese scientists edit First human tests of
Sangamo BioSciences South Korea demonstrate cells in a lab dish, a the DNA of human CRISPR, as part of
initiates an effort to cure CRISPR as a new, team at Duke University embryos. Within cancer treatments, win
HIV with blood cells from much easier method eliminates a mutation months, the worlds initial approval in the
which it has, for the first of changing human that causes Duchenne scientists condemn US and China.
time, deleted a human genes. Editas Medicine muscular dystrophy. as irresponsible any
gene. is founded in Boston attempt to make
to develop CRISPR gene-edited babies.
treatments.
54 FEATURE Issue 73
The company, founded by several of the inventors dont move for months, yet their muscles arent any
of CRISPR technology, also declared an early worse for it. That is the sort of we might just find
interest in Duchenne, licensing work done at Duke something approach favoured in basic-research
University. But its chief operating officer, Sandra labs. Now, with gene editing, he sees a direct path
Glucksmann, says it isnt providing updates on the to curing someone he knows. Since correcting
Duchenne program. Gavriels cells, Cohns lab has also created a mouse
In fact, Editas has been lying low. CRISPR could model that shares his mutation. Like Duprees, the
potentially treat so many different diseases that the mutation is one of a kind, and within a few weeks
company has been reluctant to announce what its Cohns lab will start treating the mice.
do-or-die project will be, and proving any CRISPR But then what? Cohn says he doesnt know.
drug is effective could easily take a decade. How would you even test a drug designed for one
That puts Glucksmann in a tough position. person? Who would pay for it? He says he visited
On weekends she answers emails from desperate Health Canada, the countrys regulator, and was
parents: Could CRISPR cure my child?. In theory told to come back if he cured the mice. This is
the answer may be yes, but about a quarter of the going to require a significant rethinking, he says.
IT MAY TAKE time Glucksmann has never even heard of the The fact that you and I are having this conversation
A LOT LONGER illness before. The answer Editas has been giving is the beginning of the paradigm shift.
to the parents of boys with muscular dystrophy has
THAN WE been particularly disappointing: I am very sorry to 04
THINK, BUT hear about your son. Unfortunately, we are still in
the very earliest stages of research.
SOONER OR
LATER, GENE ONE THING THATS ALREADY APPARENT is
that many inherited genetic diseases will require
EDITING WILL tailoring a CRISPR treatment to very specific
CHANGE WHAT mutations those affecting small subsets of
patients or even individual people. Take Dupree,
MEDICINE who lives less than a mile from Olson in a Dallas
LOOKS LIKE. suburb. His mutation is unique, and its not near
exon 51, so he wouldnt be helped by the first
CRISPR treatment Olson is developing.
But theres no question in Olsons mind that
Duprees mutation is correctable too, given the
technique can potentially target any spot on the
genome. Dupree now sees at least a glimmer of
a chance that someone could make a CRISPR If CRISPR can reach enough of these wasted
treatment just for him. Its only given once, and muscle cells a one-off treatment could work.
maybe its not that expensive, he says. It made
me think about how it could be done, because I see Cohns approach of correcting individual
things moving closer. mutations has stirred hope among parents of boys
Paediatrician-in-chief Ronald Cohn at Torontos with Duchenne. This is a CURE!!! one wrote on
Hospital for Sick Children, who is also a muscular the web. His lab has used CRISPR to fix mutations
dystrophy doctor, is certain that with CRISPR in cells taken from several boys he knows, and
one-of-a-kind treatments are possible and even a waiting list he keeps in a spreadsheet currently
likely. Last December, he published a paper lists 53 children with muscular dystrophy. The
showing corrections of several rare mutations parents of all of them want to know if their child
again in cells in a lab dish, including some taken could be helped by gene editing.
from a child with dwarfism and others from another If a gene-therapy study like the one Olson plans
boy with Duchenne. That boy, 14-year-old Gavriel is successful, and if CRISPR reaches enough muscle
Rosenfeld, is the son of close friends of Cohns in cells, there might be a strong argument that a one-
London. They run a charitable foundation that off treatment would work. After all, to aim at a new
Cohn advises. mutation all you would do is tweak the component
Cohn is a newcomer to CRISPR. A few years of CRISPR that zeroes in on a specific DNA
ago, he was studying hibernating squirrels. They sequence. The price of manufacturing a single
COSMOS FEATURE 55
dose also might not be an obstacle. Two existing Side effects could also be an obstacle. CRISPR
gene therapies approved in Europe cost has the potential to cause accidental, unwanted
US$1 million and US$665,000. Even if it cost twice edits that could not be erased if they ended
that, a one-time gene fix with CRISPR would be up written into a persons genome. Currently
cheaper than a lifetime of costly drugs, wheelchairs researchers rely on academic computer programs
and dependency. to predict such effects. But a program cant predict
In holding out the hope of individual cures, everything. Two early tests of gene therapy in the
Cohn admits he has created some new problems. 2000s accidentally caused leukemia in several
He has invited parents to the lab, and little boys children. No one had anticipated that consequence
have tottered among the lab stools. But he and of changing the genome. Although Olson says
his students have decided to stop referring to he has not seen ill-effects in his mice, he allows
Gavriels cells or Jakes cells and use numerical that CRISPR can cause inadvertent changes in
code names instead. They still know who is who, but DNA that are important for life. Editing billions
this gives them space to be impartial. I know in the of individual cells in a persons body, scientists
back of my head, but you want to stay unbiased, acknowledge, will be the surest way to discover how
says a graduate student in the lab, Tatianna Wong. CRISPR can go wrong.
I cant work on this case just because I feel bad for It may take a lot longer than we think, but
him. I have scientific questions to answer. sooner or later, gene editing will change what
medicine looks like. The biotechnology industry
SOME VETERANS OF GENE THERAPY roll their began in the 1970s when someone grafted insulin
eyes when they hear what newcomers think into E. coli, showing that a human protein could be
CRISPR will do. I visited the vector development manufactured outside the body. Now theres a way
centre at St. Jude, touring a cramped L-shaped lab to change DNA where it lies, inside your genes.
with Byoung Ryu, an expert in making viruses, who When he looked through a microscope at his
chops the air above his head and says, peoples own cells in Olsons lab, Dupree tried to take the
expectations are up here. Ryu warns that basic, rational view: here was a solution for the next
unresolved biological problems remain. One is generation of boys. His mother, however, allowed
whether editing will work often enough in cells such herself to hope. I was ecstatic. I remember
as those in the bone marrow, the type that need thinking: this could be something that works,
to be changed to correct sickle-cell disease. If too Debbie says. Duchenne is a ticking clock. Parents
few cells end up edited, the treatments wont be cant help making the calculations: this long for
effective. Its a numbers game, he says. animal studies, this many years for the first human
Ryu was the first employee at a Boston-area trial, that much more time until they know if it
gene-therapy company, Bluebird Bio, whose stock really works. Luckily, Duprees disease is the
price staggered down the chart after its first few slow-moving kind. The doctors said hed be gone
patients didnt all respond the same way. Im not by 19, but hes still here. Maybe hell still be here
negative on CRISPR, but there is a reality check, in 10 years, says his mother, so they can try it
Ryu says. Its not coming to people next year. It on him.
works in the petri dish every single time, but my
perspective is that genome editing may happen in
the future but not in the near term. ANTONIO REGALADO is the senior editor for
CRISPRs future as a treatment depends heavily biomedicine for MIT Technology Review.
on the skills of gene therapists like Ryu. Theyve
been making progress, yet so far only two gene
CREDIT
therapies the kind that add an entire gene
MIT technolgy Review, Copyrighted 2016.
have reached the market to address an inherited
126775:1216SH
disorder. One, called Strimvelis, provides an
outright cure for a fatal immune deficiency and was
approved in 2016 in Europe. It took 15 years to IMAGES
test it on 18 children, and similar trials had failed. 01 d1sk / Getty Images
What I learned about gene therapy is that the 02 Supplied by Benjamin Dupree
rabbit does not win the race, says Weiss, who leads 03 Hao Jiang / Getty Images
the St. Jude effort to apply gene editing to sickle-cell 04 CMEABG-UCBL-CHAPON / Phanie /
disease. The tortoise wins the race. Getty Images
56 PROFILE Issue 73
ROSS
GARNAUTS
BRIGHT IDEA
01
58 PROFILE Issue 73
LAST JULY , shortly before his 70th birthday, TALL AND SLENDER with a corona of thinning
Garnaut took the reins of one of the most ambitious gray hair and wire-frame glasses that give him
renewable energy initiatives in the world: a A$100 the appearance of a bookish academic, the mild-
million (about US$75 million) solar energy fund, mannered Garnaut has become one of the southern
part of a larger plan to sink $A1 billion into solar hemispheres most respected and sought-after
infrastructure in Australia by the end of this decade. climate advocates, keynoting conferences where
The year before, the Perth-born economist became he is often surrounded by a scrim of reporters.
chairman of clean tech outfit ZEN Energy, based Yet just a decade ago, environmental rock star
in Adelaide. is something he never thought would be on
A decade ago, as an adviser to the Australian his resume.
government, Garnaut authored a ground-breaking Back then he was a trusted economic advisor
report on the economic impact of climate change to a succession of prime ministers. As a respected
that catapulted him to national prominence. researcher and lecturer at the Australian National
Now determined to steer his country towards University in Canberra, Garnaut was in convenient
a low-emissions future, the grandfather of seven proximity to the nations seat of power. He had
believes the private sector is the best place to served on the board of nearly a dozen different
channel his energies. companies, organisations and academic journals,
The stakes could not be higher: Australia has and chaired four of those businesses, including
been whipsawed by extreme weather throughout a gold mining outfit headquartered in Papua
its history, but global warming is amplifying these New Guinea.
fluctuations. Witness the increased incidence and Hardly the profile of a sandal-wearing
intensity of natural disasters including floods, heat tree hugger.
waves, and bushfires of unimaginable ferocity. But in 2007, in the midst of a harsh, decade-
Warming has also worsened coral bleaching on the long drought that turned the grasslands of the
Great Barrier Reef and threatens unique terrestrial agricultural heartland into dust bowls and forced
species, from Western Australias banded hare water rationing in coastal cities, Kevin Rudd,
wallaby to Queenslands Lumholtzs tree kangaroo. the head of the Australian Labor Party, and state
Yet despite the obvious dangers, Australia and territorial leaders asked Garnaut to put
remains heavily reliant on coal: domestic together a report on the economic fallout from
consumption accounted for more than 61% of a rapidly warming planet. When Rudd became
electricity generation in 2015, according to a prime minister in December 2007, the report was
2015 report from the Australian Department of sanctioned by the Australian government.
Energy and Science. Australia is the worlds largest Garnaut was aware of climate change, but
exporter of this dirtiest of all fossil fuels. he thought of it as merely one of thousands of
With such deeply entrenched vested interests, pressing issues jostling for attention. In the course
Garnaut has no illusions about the difficulty of of researching the report, he had a life-altering
turning the tide. But he will spend the rest of his epiphany: if we failed to mend our carbon-chugging
life trying. ways, we were headed for catastrophic disruption,
No other developed country is as vulnerable to he remembers thinking. The failure of our
the effects of climate change as Australia, he warns, generation on climate change mitigation would lead
and the consequences if humanity fails to deal with to consequences that would haunt humanity until
this issue are very severe. the end of time.
COSMOS PROFILE 59
While Garnaut is a late-comer to the combination of wind and solar, Garnaut says.
complexities of climate change, he has always Up the northeast coast, even in a place like
had an aptitude for science. As a student at Perth Brisbane, and just inside the Great Divide on the
Modern School in the early 1960s, he was torn Eastern Highlands, there is the combination of solar
between pursuing economics or physics, a career and bio-energy fuel derived from sugarcane
path that would have allowed him to explore the waste and other organic materials.
complexities of the universe. He participated in Yet Australia has been a global laggard: while
a summer school for top science students at the almost a quarter of the worlds electricity now
University of Sydney and loved it. But he was comes from renewables, according to a 2017 report
also captivated by the developing nations of Asia; from the International Renewable Energy Agency,
he even took lessons in Malay after school. they account for just 14% of Australias electricity
Ultimately, economics won the day a decision mix. Germany, which is hardly known for abundant
he has never regretted. sunshine, gets about a third of its electricity from
Garnauts lifelong fascination with the region renewables, and its wind farms churn out so much
beyond Australias borders is part of what drives power that the state has to pay companies to switch
his now relentless push for climate protection. off their turbines to avoid overloading the grid.
In a career spanning more than 40 years Garnaut is convinced Australia could be no less
including an early stint helping Papua New Guinea a renewables leader. In a speech this past October
transition to independence and four years as at a renewable energy summit in Adelaide, he
ambassador to China in the 1980s, he has watched said South Australia, in particular, could be a
the developing nations of the Pacific basin undergo superpower of the low carbon world economy.
wrenching upheavals.
OFTEN,
I spent my life working on questions of THE ROAD TO THIS TURNING POINT has IT IS GOOD
development, he says, and that taught me that no been decidedly bumpy. When Garnaut dove
matter how bad things are, things can get worse. into climate change policy a decade ago, there
PEOPLE WHO
He recalls his days as a PhD candidate working was bipartisan support for action to reduce GIVE UP.
in Indonesia in the late 1960s in the aftermath of Australias carbon emissions. Both major parties
the overthrow of the Sukarno regime by General went to the 2007 election promising to introduce
THATS
Suharto, witnessing the country teeter on the an emissions trading scheme, which would allow WHEN THE
precipice of chaos: Often, it is good people who emitters to buy and sell carbon dioxide permits
give up. Thats when the bad people have a very to stay within an overall limit. In his report, called
BAD PEOPLE
big win. the Garnaut Climate Change Review, published HAVE A VERY
Such experiences have given Garnaut a special in September 2008, he calculated the national
sense of urgency in trying to thwart the worst economic costs of failing to take action and laid
BIG WIN.
consequences of climate change. South and out market-based policies to cut emissions
Southeast Asia are particularly vulnerable, he says. at the lowest possible cost.
The biggest damage wont come from the effects But by 2011, when Garnaut undertook an
of drought or flood or extreme weather; the biggest update of the review, consensus had evaporated.
damage will come from the destabilising effects of The Rudd governments attempt to enact emissions
unmitigated climate change when the institutions trading had been thwarted by opposition in the
that keep a society together fall apart. parliament, and his successor, Julia Gillard, was
Australia, with its strategic relations with forced to embrace an alternative scheme a carbon
Indonesia and other South Pacific island nations tax. Garnauts update again provided a roadmap,
likely to be profoundly impacted by climate change, which included a proposed starting price for a
is not immune to these problems. As the largest carbon tax and an analysis of how the scheme could
developed country in the Oceania region, Garnaut help reduce emissions.
says, Australia is a big part of the climate problem, Opposition was fierce. Fossil-fuel interests
but it can also be a major part of the solution. launched a well-funded campaign warning of dire
The irony is that while Australia continues economic consequences. If youve got a problem
to burn its extensive fossil fuel reserves, it is also that requires a difficult and costly response, he
blessed with what Garnaut calls an exceptionally says, choosing his words carefully, some people
rich endowment of largely untapped renewable would prefer not to think about it.
energy sources. Across southern Australia, even Garnaut, who was still on the ANU faculty,
in my home town of Perth, youve got a wonderful found himself the target of death threats and
60 PROFILE Issue 73
astroturfing slick PR campaigns designed and harness Australias vast reservoir of affordable
to create an artificial grassroots opposition renewables. Id have dinners with chief executives
movement. It was deeply contentious and I was of major energy companies and talk about what
under huge pressure, he recalls. Thousands of they could do to position themselves and make
emails condemning the report were sent to every happen the things that could lead the Australian
journalist and politician to create the impression energy transition. Id get a very polite hearing
of a movement in opposition. and have a nice dinner but there wasnt any
Garnaut soldiered on, continuing to support interest, he recalls.
the carbon tax. At the end of 2011, parliament He began to think about what he could do
passed the carbon tax package, which included himself. A friend, Raymond Spencer, who had spent
$13 billion in funding to encourage innovation 20 years in Chicago building up an information
in clean energy technology. It also established the technology business, had returned to his native
Australian Renewable Energy Agency (ARENA) South Australia and bought into ZEN Technologies,
to support early stage research and development. a company that has supplied solar and storage
But the tax did not last long. After the Liberal systems since 2004. A proposed spin-off, ZEN
National coalition, led by carbon-price opponent Energy, had ambitious plans to scale up renewables
Tony Abbott, won government in 2013, it promptly generation from residential and small businesses
set about dismantling the scheme, and in 2014 to a level that could provide energy to entire
it was abolished, much to Garnauts chagrin. communities and industries. I felt the company
The tax seemed to be working: carbon emissions could be part of the story of innovation in the
had declined by about eight percent, he notes energy sector, Garnaut says of his decision to help
(though some of the decline may have been due launch ZEN and become chairman. My motive is
to the economic downturn). We went for a couple to provide a vehicle that can smooth the Australian
of years where emissions were falling, Garnaut transition to zero emissions.
says, but now its all gone in reverse. The centerpiece of ZEN Energys effort are
Frustrated, Garnaut sought other ways to massive battery banks that function a bit like
hasten the move away from fossil fuel dependency mini-power stations. About 200 lithium-ion
CLEAN ELECTRCITY IN AUSTRALIA Globally, renewables account for 23.5% of electricity generation.
At 14.6% Australia is lagging behind.
14.6%
12.1% 4.4% Renewables
Western
Queensland
Australia
7.7%
New South
Wales
41.3% 85.4%
South Australia 12.1% Fossil fuels
Victoria
99.9%
Tasmainia
DATA: CLEAN ENERGY COUNCIL, AUSTRALIA 2015
COSMOS PROFILE 61
cells are stacked inside a 40-foot-long shipping In July 2016, the South Australian government
container and generate about one megawatt of awarded ZEN Energy contracts to install
power enough to power up to 1,000 homes. battery storage demonstration systems at three
For comparison, the capacity of coal-fired power government-owned buildings in Adelaide, with
stations in Australia ranges from 300 to 2,880 the intention to show that the buildings carbon
megawatts. footprint could be reduced while saving money in
While these battery powerhouses may not the long term. If successful, these types of projects
look quite as impressive as an array of sleek, shiny could lay the groundwork for the large-scale rollout
solar panels, theyre key to overcoming a long- of sustainable energy systems.
standing challenge in making renewables such as The geniuses who oppose action on climate
solar and wind reliable. Power has to be available change like to broadcast their discovery that the
on demand at any time, and sunshine and wind are wind doesnt blow all the time and the sun doesnt
not constant. shine all the time so you cant rely on it, Garnaut
The ZEN Energy system combines community- dryly observes during an interview early one
scale battery arrays that can store up solar surpluses Saturday morning from his home in Melbourne,
during the day and wind energy at night with where he is on the faculty of the University of
intelligent software to distribute the banked supply Melbourne. But the right combination of diverse
during times of peak demand. A major advantage renewables and storage in different places can
of ZENs approach, Garnaut says, is that it can give you a reliable supply, and at a lower cost than
integrate diverse sources of renewables, including building a new coal-fired power station.
hydro and biomass energy, into customised systems Batteries themselves are becoming more
that improve energy security and cut energy costs, efficient and affordable. In the past decade, as
allowing some users to meet their needs completely battery storage technology has matured, prices
off-grid. It works for homes, businesses and even have tumbled by 70% for lithium-ion batteries.
large scale industrial operations, such as farms or Teslas second-generation Powerwall, unveiled
sheep or cattle stations even mining companies late in 2016, is a sleek closet-sized battery with
like the one he once worked for. twice the capacity of the original model released
33,000
GWh
2020 target
Hydro Wind Solar < 100 kW Large-scale solar >100 kW
5.9% 4.9% 2.4% 0.12%
of total electricity of total electricity of total electricity of total electricity
generated generated generated generated
15,200
GWh
as at 2015
Bioenergy Marine Geothermal Solar water heating
1.3% 2 1 958,000
of total electricity operational operational total installations
generated plants plant
62 PROFILE Issue 73
less than 12 months before at about the same price. under construction one in Karratha, Western
The battery provides enough backup power to keep Australia, and two near Canberra. The largest of
the lights on and appliances humming in a typical the projects, the 11.2 megawatt Williamsdale Solar
two bedroom home. Farm, is expected to generate enough electricity for
Similar to Tesla, CSIRO has deployed its own 3,600 households.
version of a smart battery system. The federal Were expecting 2017 to be the year when
science research agency has teamed up with large-scale solar really takes off in Australia, says
Evergen, a Sydney-based startup, to sell and Darren Gladman, director of smart energy for the
manage home energy systems based on CSIRO- Clean Energy Council, an industry trade group
developed technology. The systems analyse headquartered in Melbourne.
weather forecasts along with snapshots of typical
household energy-use patterns to select the most ENCOURAGED BY THE MOMENTUM thats
efficient and economical energy source. If you like beginning to build, Garnaut believes the dream
to turn on the air-conditioner at 8am on summer of a low-carbon Australia is achievable within
mornings but the system knows it will be cloudy his lifetime. The share of renewables is steadily
THE US tomorrow, it can charge its battery overnight, climbing there was a 20% increase in wind and
WITHDRAWING drawing power from the grid at the cheaper solar generation in 2015 and costs for solar are
off-peak rate. expected to plummet at least 35% in the next couple
FROM PARIS, This is what we call a managed battery system, of years. Tasmania already has the capacity to
OR PLAYING says Glenn Platt, director of CSIROs Grids and generate all its electricity from renewables (thanks
Energy Efficiency Systems Research Program to hydropower), and more than 40% of electricity
DEAD, and Evergens former chief executive. Evergen in South Australia comes from sustainable sources.
SHOULDNT has an automatic system that learns when you use In states such as Queensland and New South Wales,
electricity in your house, forecasts what the sun though, the percentage of electricity generated by
STOP THE is going to do later in the day and then selects the renewables remains in the single digits.
STRONG most efficient energy source to minimise home Garnaut believes the world is well on the way
energy costs. to a zero carbon future, even with Donald Trump,
MOMENTUM Whats more, several major projects are on who threatened to scrap the Paris climate change
TOWARDS the drawing boards or that are scheduled to break agreement that went into force last year, in the
ground some time this year, that will help form the White House. The US withdrawing from Paris,
MUCH LOWER scaffolding of a 21st century sustainable, reliable or playing dead, shouldnt stop the strong
EMISSIONS energy infrastructure. momentum towards much lower emissions in
ARENA has teamed up with one of Australias China, Europe and other countries in which it
largest electricity suppliers, AGL Energy, to create is now well-established, he says though he
the worlds largest battery storage virtual power adds that the absence of US leadership might be
plant. The $20 million project harnesses the decisive in countries still making up their minds
output of 1,000 batteries in homes and businesses about strong action.
in South Australia. The 1,000 systems, which are But anything less could be cataclysmic, which
connected through centralised monitoring and is why Garnaut feels so compelled to push for a
management software, have a combined storage carbon-free future. I worry about the fate of our
capacity of 5 megawatts. species, he says. I think all of us are capable of
On the generation front, ARENA is funding a doing bad things, but Abraham Lincoln had it right:
dozen new large-scale solar projects in Queensland, this will only work when we appeal to the better
New South Wales and Western Australia that will angels of our nature.
triple the energy output from large-scale solar in
Australia to about 727 megawatts. ARENA also has
launched demonstration projects that use hybrid
LINDA MARSA is a Los Angeles-based journalist and
systemscombining solar, wind and diesel
contributing editor at Discover. She is the author
to power remote islands and hamlets in the bush.
of Fevered: Why a Hotter Planet Will Harm Our
Garnaut also has a hand in large-scale solar,
Health and How We Can Save Ourselves.
as chairman of a fund established by the Impact
Investment Group that plans to acquire and
manage up to A$100 million in solar investment. IMAGES
The fund has rights to three large-scale solar farms 01 David Geraghty / Newspix
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COSMOS SPECTRUM 65
PEOPLE, CULTURE
& REVIEWS
SPECTRUM
ZEITGEIST
More than
memory
The true purpose of the worlds great prehistoric sites were to act
as vast repositories for cultural knowledge, argues Australian oral 01
history researcher Lynne Kelly. JIM ROUNTREE reports.
66 SPECTRUM Issue 73
ZEITGEIST
More than memory from the landscape myths you learnt as a child. The whole
of your country serves as a gigantic mnemonic device for
this knowledge.
The trick of using stories tied to features in a location
Most of us know a place where sculptured rocks, as a memory aid is no secret. Modern speed-memory
majestic trees or perhaps the light give us a feeling the competitors use the technique, linking each card in a deck
place is special. We sense something mysterious and to locations within a familiar place pictured in the minds
wonderful beyond the normality of everyday life. eye a so-called memory palace, a mnemonic device first
Now, imagine you are young and visiting such a place. used in ancient Greece and Rome.
It is in the land of your people, a clan of hunter-gatherers. Ethnologists have known for some time how
Your parents tell you the story of the place. You can see the preliterate societies told stories linked to their
marks left as mythical ancestors fought and played, acting environments. We can see the method in oral cultures of
out momentous, tragic events. Native Americans, Africans, Polynesians and Australian
You will never forget this story, and you will never Aborigines.
forget the place. They are locked together in your mind. Once all peoples must have used systems of this kind.
But the story doesnt stop there. The ancestors In the Western tradition, for example, the Iliad was
roamed clan territory, leaving traces at every point. recited from memory.
Its easy to remember their bizarre, dramatic acts, which
become inseparable from the marks they left behind on 02
the landscape. Story and land merge in a mental map that
means you always know where you are and what lies in
every direction.
Now you are older and ready to be initiated. Back
at the special place you learn there is more to the story.
The ancestor turned into a millipede leaving those marks
one for each verse of a song you must now learn; many
generations old, it holds vital information you cant afford
to get wrong.
Time passes you are an elder. You know a thousand
songs, chants, stories and dances. They tell about the
animals their life cycles, how they feed and breed, how
to hunt them and the rules for dividing the kill. You know
which plants you can eat and how to prepare them. The
songs tell you the clues, on land and in the night sky, of
the passing seasons, so you know when to move as game
becomes abundant or plants fruit. The songs tell you the
laws of your people and the gods and spirits you must Prehistoric animal outlines such as this one on
appease. They contain your peoples history and relations Perus Nasca Plain may have helped early
with neighbouring groups. peopes pass down knowledge.
As an elder you have authority, with others, to create
new stories for events worthy of memory. In her latest book, The Memory Code, Australian
With so much to remember you have songs to list and science writer and La Trobe University oral history
a ceremonial cycle mapped to each of the locations you researcher Lynne Kelly stresses the effectiveness of
visit, so you can be certain that every story is regularly the method to accurately remember and transmit vast
rehearsed. amounts of knowledge. This sets the ground for her
Spread through your mind and the minds of others main thesis: that numerous prehistoric sites around the
in your group is the total knowledge of your people. It is world had a primary function as memory aids, serving as
a repository of incredible detail, containing information knowledge centres for peoples transitioning from hunter-
of practical importance as well as the beliefs that define gatherer to settled agricultural lifestyles. Her list includes
your understanding of the universe and your place within henges, cairns and standing stones in Western Europe,
it. Without a written language, you must keep it ever Gbekli Tepe in Turkey, Neolithic temple complexes in
alive and pass it on completely and accurately. So of Malta, Pueblo great houses in the southwestern United
course, you use the method by which it came to you, States and the giant, geometric animals cut into the Nasca
in interwoven branches of story and song that emanate Plain in Peru.
COSMOS SPECTRUM 67
SNAPSHOT
An Icelandic
crystal cave
IMAGE
Stanson / Getty Images
COSMOS SPECTRUM 69
70 SPECTRUM Issue 73
REVIEWS
NOTED READING
REVIEWS
NON-FICTION
A World of Information
by JAMES BROWN and
RICHARD PLATT
BILL CONDIE
COSMOS SPECTRUM 73
THEORETICAL PHYSICISTS are an idealistic of technical holes in the theory, questioning, in the
lot. Theirs is the noble struggle to understand tone of a bemused schoolmaster, why they have not
the nature of the universe: to know, as Stephen been seriously addressed.
Hawking put it, the mind of God. Yet physicists His next target is an even larger one: quantum
are human too subject to the whims of fashion, mechanics, the best-tested theory in physics, and its
dogmas of unquestioning faith and flights of most perplexing. For Penrose, quantum mechanics
unadulterated fantasy. is faith because its mathematics uses assumptions
These human flaws have led to the present that could never be logically justified and nobody
impasse in physics, warns Sir Roger Penrose. His really understands the theory anyway. For example,
penetrating new book is the long anticipated follow- we dont know why the laws of physics seem to have
up to three eponymous lectures he gave at Princeton two regimes, one for the very small and another for
in 2003. In those talks, he called out the problems, the very large. For Penrose, this disconnect is a sign
NON-FICTION both sociological and technical, in the way physics that quantum physics is incomplete, and we must
Fashion, Faith and is done today. In particular, he calls string theory a search for something deeper.
Fantasy in the New fashion, quantum mechanics faith, and cosmic Fantasy is how Penrose refers to the wild notions
Physics of the Universe inflation a fantasy. describing the universe at the largest scales. Here we
by ROGER PENROSE Penrose is well placed to make such sweeping run through some of the strangest ideas in physics
judgements. He has been a giant of physics and (concerning, for example, what is inside a black hole,
Princeton University mathematics for five decades, making many deep, or what happened before the Big Bang). Penroses
Press (2016) original insights into topics ranging from black hole true quarry is the theory of inflation, a description of
RRP $29.95 physics and the origin of the universe to art and the universes faster-than-light expansion in the first
fundamental geometry. For example, his exploration moments after the Big Bang, which he argues has as
of impossible objects, such as the Penrose Stairs, many serious flaws as its competitors.
inspired the artist M.C. Escher to create some of his When Penrose describes a theory as fantastical
most famous woodcuts, including Ascending and he is not necessarily being disparaging. The universe
Descending and Waterfall. In the estimation of the is full of apparently fantastic notions that are
Perimeter Institutes Lee Smolin, there is no one demonstrably valid the Big Bang origin of the
who has contributed more to our understanding of universe, for example, or the existence of black holes.
the general theory of relativity, save Einstein himself, Wild ideas can be appropriate; but only when they
than Roger Penrose. describe our observations better than rival ones.
Penrose is renowned as a fiercely independent In the final chapter, Penrose lays out two wild
thinker, even a maverick, and its in this role as theories of his own. The first, conformal cyclical
iconoclastic outsider that he tackles the big problems cosmology, is his self-described crazy theory
facing physics today. Fashion has long played a that the universe has no beginning or end; rather
role in science. To remind us of how spurious ideas it iterates through infinite cycles. The heat death
can achieve a status of dogma, he describes several of one universe becomes the Big Bang of the next.
once-fashionable theories of history. For example, Meanwhile, twistor theory is Penroses stab at
Ptolemys theory of epicycles (the idea that the orbits linking general relativity and quantum mechanics.
of the planets could be described by circles upon The twist comes from the idea that quantum spin is
circles) was kept alive through 14 centuries of mental tied up in spacetime. Though Penrose first suggested
gymnastics by proponents who placed Earth at the the theory in the 1960s, it has seen a surge in interest
centre of the universe. in recent years.
Todays modern equivalent, perhaps, is string For technically minded readers keen to achieve
theory, the idea that all of physics is based on a deep appreciation of the problems facing physics,
fundamental vibrating strings, far tinier than any this is an enlightening book. Just dont expect the
quark or electron. The idea, so tantalising in its spoon-feeding of popular science; there are more
simplicity and scope, has dominated theoretical equations than metaphors. (For a more digestible
physics for two decades despite making no testable account, Lee Smolins 2006 book The Trouble with
predictions. Joseph Polchinski, a leading string Physics covers much of the same ground.)
theorist has said there are no alternatives all good This book is a reminder that the universe is a
ideas are part of string theory. weird and wonderful place, and a mind-bending tour
For Penrose, on the other hand, string theorys of one of physics most original and radical minds.
stranglehold on developments in fundamental
physics has been stultifying. He exposes a series CATHAL OCONNELL
74 SPECTRUM Issue 73
REVIEWS
JOHN PICKRELL ISNT VERY HAPPY with the latest to an island would have experienced different
iteration of the Jurassic Park movie franchise, and evolutionary pressures than their mainland
the Sydney-based science writer makes no attempt counterparts, and that perhaps the land on which
to hide it in his new book Weird Dinosaurs, which the bones were found had once been isolated by
explores hundreds of new dino-discoveries made water. Food and space are often scarce in island
in the past couple of decades. In Pickrells previous environments, which means their inhabitants can be
book, Flying Dinosaurs (Cosmos, Issue 58, p89), he naturally selected for dwarfism, because the smaller
examined our new awareness that a vast array of the animal needs less food to survive.
dinosaurs assumed to be scaly were actually fluffy, In 2010, researchers analysed the internal detail
like modern-day Bantam chooks. of the bones to establish beyond doubt that Nopcsa
In his introduction to Weird Dinosaurs, Pickrell had been right these were dwarf versions of some
describes visiting Londons Natural History of the larger dinosaurs found in other parts of the
NON-FICTION Museum and being chuffed to see its famous life-size world, and Transylvania was indeed an island in the
Weird Dinosaurs animatronic Velociraptor had sprouted feathers, in late Cretaceous period.
by JOHN PICKRELL line with the latest science. Jurassic World, released Weird Dinosaurs is full of these fascinating tales,
in 2015, didnt show the same responsiveness. delivered with descriptive aplomb. Pickrell is the
NewSouth Publishing Jurassic World didnt take on board any of the editor of Australian Geographic (and a former deputy
(2016) really exciting new science and I think that was a editor of Cosmos), and his background in science
RRP $29.99 missed opportunity, Pickrell tells me. Not to show journalism allows him to describe prehistoric scenes
dinosaurs as we now know them to have appeared is in vivid colour and minute detail.
spreading misinformation. In the chapter Monster from the Cretaceous
Feathers aside, Weird Dinosaurs tells us there Lagoon, for example, he brings us to a riverbank in
has been a boom in dinosaur finds in the past two northern Africa 95 million years ago the buzzing
decades, including 150 new species uncovered insect soundscape, the beat of the midday sun, and an
in China alone. About half of all known dinosaur enormous predator lurking beneath the water.
genera have been found in the past 10 years, and A fizz of bubbles hints at the presence of giant,
three-quarters since 1990. The explanation is pretty car-sized coelacanths and lungfish lazily moving
simple. We have started to look for dinosaurs in through the waters, he writes. None of these fish
earnest in parts of the world where we havent spent has noticed what is stealthily gliding towards them
much time looking for them before, and there are below the water with a flick of its great tail. Made
also more people looking, Pickrell explains. obvious above the water by a great red sail, which
Broadly, this dinosaur discovery boom is what slices through the surface, this killer moves almost
Weird Dinosaurs is about new animals being added silently and invisibly through the murky waters.
to our prehistoric awareness. More specifically, From Alaska to Australia, Pickrell describes
though, the book is a charming collection of short in vibrant detail the thrill of discovering fossils
stories, depicting the most unique and surprising and ponders the question, what marvels are lying
dinosaurs, and the weird and wonderful people who undiscovered in dark cabinets around the world?
study them the true Indiana Jones characters of the And if weve only just discovered three-quarters of
palaeontology world. the dinosaurs known to science, what might be next?
One story starts with a Transylvania aristocrat, Pickrell says there could be whole new dinosaur
Franz Baron Nopcsa, who among his many fauna waiting to be discovered.
adventures roamed Austria-Hungary on motorbike, This book does its part to pique the interest of
became a World War I spy, and put in a bid to become this nascent army of dinosaur-hunters. Pickrell says
king of Albania before shooting himself and his long- it was his pleasure to take the stories of experts and
time boyfriend in 1933, just after the rise of Hitler. translate them for a broad general audience.
After discovering fossils on his lavish family I spent a lot of time meeting palaeontologists
estate estate in the 1890s, Nopcsa immersed himself in countries all over the world, getting them to tell
in study until he was qualified enough to analyse me about dinosaurs and their own exciting tales of
them himself. He is credited with describing a suite discovery, he says. I found that a great privilege and
of miniature dinosaur species found around his huge fun. The enthusiastic dinosaur hunter is alive
hometown of Haeg. These include a cow-sized and well with this writer. He isnt the first, and this
version of a sauropod that in other parts of the world book suggests he will not be the last.
reached 70 tonnes in weight.
Nopcsa hypothesised that dinosaurs confined AMY MIDDLETON
COSMOS SPECTRUM 75
GADGET
DRONE
AirSelfie
AIRSELFIE HOLDINGS, LONDON
Abacus
This is what they did:
i x i = -1
which, rearranged, reads:
The gleam i = -1
in the i The new species of number here is
symbolised by i because in the early days it
was considered an imaginary number
rather than a real number.
Many mathematicians were suspicious
and even derisory about it. The name
has stuck, even though today we accept
Imaginary numbers make the imaginary numbers are just as real as real
universe real numbers. You can get more imaginary
numbers by multiplying i by real numbers
THE OLD APHORISM my enemys 2i, 3i, 4i and so on and there is no
enemy is my friend has a mathematical problem combining real and imaginary
equivalent: multiplying two negatives numbers. For example, 5 + 3i is a perfectly
makes a positive. In monetary terms, good number. Such combinations are called
where a negative number is definitely complex numbers, though the rules for
the enemy, it is the same as saying that manipulating them are very simple.
reducing a debt is equivalent to making What are imaginary numbers good for?
a gain. It turns out that by embracing i, the scope
The simplest case of two negatives and power of mathematical manipulations
making a positive is: is enormously broadened, opening the way
-1 x -1 = 1 to a plethora of new shortcuts and tricks.
Multiplying a number by itself is Exponential growth and decay (which
known as squaring the number, so the I explained in Cosmos issue 71, p76) when
square of -1 is 1, the square of -2 is 4, raised to the power of i superimposes a
and the square of -3 is 9, etc. However, wave-like oscillation on to the pattern of
the square of 1 is also 1, the square of 2 is 4 growth or decay. The world is replete with
and so on. The square is the same whether quantities that oscillate and either grow
the number is negative or positive. or decay at the same time. For an example
Going backwards, a procedure of how this works, think of a swinging
called taking the square root reverses pendulum that gradually slows it
the result. The square root of 9 is 3, but oscillates as it decays. Using i also greatly
it is also -3; there are two solutions to any simplifies the mathematical description of
square root calculation. systems that use complicated oscillating
All this is well and good, and drummed waveforms, such as acoustic and electronic
into most of us in school, but what happens signals.
if you try to take the square root of a But imaginary numbers are not
negative number, such as -9? No ordinary just a computational convenience.
number, when multiplied by itself, yields Mother Nature got there long before
-9, so how can you do the reverse? mathematicians. We have known since
This question stymied mathematicians Einsteins theory of relativity that
for years. What they finally figured out was space and time are not independent but
the need for a new type of number entirely. fundamentally tied together by the speed of
By the 18th century, they extended the light into a unified spacetime.
number system to include the square root Though related, space and time are not
of negative numbers. the same: it is i that allows us to combine
COSMOS SPECTRUM 77
them. To measure the spacetime interval beauty contest earlier this year when the
between two cosmic events, for instance, BBC asked people to vote for the most
you have to express the time interval in the elegant mathematical relationship of all
same units as spatial distance achieved time. The winner was declared to be
by multiplying by i. One can therefore ei +1=0
say that space is imaginary time (in the where e stands for exponential. This
technical sense of imaginary numbers), formula was discovered in 1748 by the
a term popularised by Stephen Hawking brilliant Leonhard Euler, known as the
in A Brief History of Time. Hawking Mozart of mathematics. By invoking i,
discusses a theory of the Big Bang in which Euler was able to combine e with three
the universe started out with four space of the most basic elements of the entire
dimensions, so time was imaginary (in the number system: 0, 1 and . Eulers formula
-1 sense) at the outset. is a profound relationship that seems
Nature also uses complex numbers in to be speaking to us from some sort of
quantum mechanics. If you were the Great mathematical nirvana.
Cosmic Designer and tried to come up All of which raises the question of
with laws for atomic processes using only how much mathematical beauty still
real numbers, the resulting properties of remains hidden from us because of
atoms would be very different from what limitations on our existing number system.
we observe. Is there a future Euler out there who (to
Theres another reason to appreciate borrow another aphorism) will help us to
the number i: its elegance. It won a public behold it?
78 SPECTRUM Issue 73
WHY IS IT SO?
WHY
IS THE SEA
SALTY?
The water on the Earths surface was once fresh.
JAKE PORT explains how that changed.
COSMOS SPECTRUM 79
IT IS ESTIMATED there is enough salt in the worlds A similar process involves the interaction of
oceans to cover all the planets land surfaces with submarine volcanoes with surrounding seawater.
a layer about 40 stories thick. But seawater wasnt Submarine volcanoes are comparable to their
always so salty; when the Earths oceans first formed above-ground relatives except that their lava cools
about 3.8 billion years ago, as the surface of the planet much more rapidly, allowing for speedy growth.
cooled enough to allow water vapour to liquify, the Magma erupting through submarine fissures boils
oceans were mostly fresh water. So where did all the the surrounding water, which then dissolves salts
salt come from? in the cooling rock to escape in a manner similar to
It came from rock, laden with elemental salts hydrothermal vents. Many of the worlds islands were
including sodium, chlorine and potassium, that formed by this process, releasing thousands of tons
was spewed forth as magmatic material by massive of salt in the process.
volcanos from the depths of the planet. While seawater contains, on average, about
Enter erosion, the process liberating these salts 35 grams of salt per litre, the oceans and seas are not
from their rocky prison, thanks to an atmosphere uniformly salty; generally the closer you get to the
dominated by gases including nitrogen and, poles the less saline the water becomes, as fresh water
importantly, carbon dioxide. released from the ice of the frozen poles dilutes the
When mixed with water (H2O), carbon dioxide concentration of the salt.
(CO2) can form carbonic acid (H2CO3), a weak but There is still one question left: if most of the salt
corrosive acid. This carbonic acid rained down in the sea comes via rivers and streams, why are they
on salt-rich rock, slowly breaking through and not also salty? The simple explanation is that they do
releasing the trapped salt into rainwater. The contain salt, but the concentration is much lower, and
runoff slowly carried the salt to nearby lakes and the salt flows rather than accumulates. It is estimated
rivers, which in turn carried it to the seas. Although that each year four billion tons of dissolved salts are
the amount deposited by any one outlet was small, carried to the sea by rivers.
the contribution of millions of outlets over millions So is the ocean getting saltier? The answer right
of years gradually riased the salinity of the oceans. now is probably not. The input of salts is balanced by
The process continues. salts being buried underground by the movement
Along the way from rock to sea, a fair proportion of tectonic plates, the flow of freshwater and a host
of the salt released from rock is used by living things. of other processes.
Salt is crucial to both plant and animal life, regulating
the amount of fluid in cells and neuron function.
JAKE PORT , a Melbourne-based writer,
When an organism dies and decomposes, the salt
contributes to the explainer series on
is freed to continue its seaward journey.
cosmosmagazine.com
Acid rain isnt the only way the seas are fed with
salt. Ongoing volcanism still has an important role
to play. Hydrothermal vents allow seawater that has IMAGE
seeped though the rock of the oceanic crust to return Tommy Clarke / Getty Images
to the surface. The water is superheated from magma
below, and as it travels up it dissolves minerals locked ILLUSTRATIONS
in the crust, erupting as mineral-rich steam. Jeffrey Phillips
80 SPECTRUM Issue 73
Quiz
Q1. Coconut crabs were found to be able
to lift how much weight, in kilograms,
with their claws?
QUIZ
1. 67P/Churyumov-
Gerasimenko
2. The Rosetta stone,
a tombstone-sized
slab of granite that let
archaeologists translate
Egyptian hieroglyphs.
3. Papua New Guinea
4. 37,000 years
5. Autophagy
6. Lysosome
7. United States
ACROSS 8. Rotaxane
3. Amphibians split from the 15. Just enough starlight 5. Immune cells in the brain 9. Beta amyloid
groups that would give rise reaches planets located that consume waste and 10. Four
to mammals, birds, and in the _ zone to allow debris. 11. Black Sigatoka fungus
reptiles during the end of liquid water to form on 7. One of the two primary 12. Damage suppressor
this geological period. their surface. chemicals used in or Dsup
5. A neutron star with an 16. Words that sound identical deodorants that acts to
extremely powerful but mean different things. kill bacteria.
magnetic field, born from 17. An antibiotic belonging 8. Families of particles WINNERS
a supernova. to the beta-lactam subset identical to those of matter,
6. The ampullae of _ is a shark of antibiotics, used to but with opposite charge. COMPETITION
sensory organ that detects treat infections caused 9. Chemical compounds The year NASA plan to
electrical currents. by multidrug-resistant that enhance the complex send another rover to Mars
10. The name of the planetoid bacteria. flavours of aged red wine. is 2020.
that collided with earth 11. A group of over 50 galaxies
around 4.5 billion years ago in which our own galaxy, Congratulations to our
which led to the formation DOWN the Milky Way, is located winners for answering
of the moon, according the 1. A greenhouse gas 28 times (5, 5) correctly: Andrea Stone,
Giant Impact hypothesis. more powerful than carbon 14. The name given to the Arrawarra, NSW and
12. Alongside humans and dioxide. robot with the highest Matthew Seery, Beaumont
short-finned pilot whales, 2. The part of the brain robotic vertical jumping Hills, NSW. Each will
the only other species that responsible for higher agility ever recorded. receive a copy of
undergoes menopause. cognitive function, such The Best Australian Science
13. Single layers of pure as language. Writing 2016, courtesy of
carbon atoms bonded in 4. Part of the brain associated Answers will be published in New South Books.
a honeycomb formation. with fear and emotion. issue 74.
82 SPECTRUM Issue 73
PORTRAIT
Ivy Wong,
astrophysicist
BELINDA SMITH
IMAGE
f22 Photography
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