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PH~E: l,14) 694-1000

March 20, 2015 .
Dr. Margaret Chan j) f tl
World Health Organization
Avenue Appia 20
1211 Geneva 27
Telephone:+ 41 22 791 2111
Facsimile(fax): + 41 22 791 3111

Dear Dr. Chan:

It has come to our attention that the International Agency fo r Research on Cancer (IARC) has
classified glyphosate as a probable human carcinogen (Group 2A). Dur ing its review, it is our
understanding that IARC part icipants purposefully chose t o disregar d dozens of studies and
publically available regulatory assessments t hat support the conclus ion that glyphosa te does not
pose a human health risk.

IARC'sfindings are contrary to robus t scientific assessments conducted by regulatory agencies in
the EU, Canada, US,Japan and even other bodies w ith in the Wo rld Health Organization. All of
these agencies concluded glyphosate is not a carcinogen . It is doubtful tha t a scientific process
could have reached a conclusion t hat so dramatically differs from regulatory agencies around the

Conclusions about a herbicide such as glyphosaite, the most widely used crop protection product
in the world, which is used on crops grown for food and feed purposes, must be non-biased,
thorough and based on quality science t hat adheres to internationally recognized standards. As
a manufact urer of glyphosate, we would like to req uest an urgen t meeting with appropriate
personnel from your organization to address the fo llowing:

What steps can be immed iately taken to rectify this highly questionable review and
conclusion as compared to all othe r reviews tha t have been conducted with regulatory
agencies around t he glo be;
An account i ng of all studies tha t were conside red dur ing t he rev iew process, and equally
as important, an account ing of those studies tha t were disregarded;
An understand ing as to why glyphosate was selected for review in April 2014, but only
made known to the public in Septembe r 2014;
An understa nding of how part icipants and specialists were selected for participation in
this monograph; and
An accounting of all funding for the classificat ion of glyphosate by IARC,including donors.

Director -Genera. Thank you very much for your assistance .varmus@nih . Christopher P. 2015 Page 2 Safety is our number one priority . HaroldVarmus. We are very anxious to determ ine a path forward to address these clear inconsistencies . Food and Agriculture Organization of the United Nations Foodand Agriculture Organization of the United Nations VialedelleTerme di Caracalla 00153Rome. IARC Director IARC.D.D. Sincerely. Dr. Director of the National Institutes of Health National Institutes of Health {NIH). Global Regulatory Affairs Cc: Dr.:. and we know that IARC's conclusions will likely cause a great deal of concern w ith growers and consumers alike Dr.Office of the Director 150Cours Albert Thoma s 69372 Lyon CEDEX08. Wild . Ph. and potential dates and times . ·' Dr.Phil .gov Jose Grazianoda Silva. Margaret Chan March 20.. ' : Vice President . Miller '/.. Director of the National Cancer Institute NCI(National Cancer Insti t ute) BG31 RM 11A48 Mail Stop: 2590 31CENTER DR BETHESDA MO 20814 haro1d. FrancisS.D. I will be in contact with your office to inqu ire who may be available to meet with me.Italy Tel:(+39)06 57051 . France Tel: +33 {0)4 72 73 84 85 Fax:+33 (0)4 72 73 85 75 Dr.colllns@nih. M . M . Office of the Director BG1 RM 126 l CENTER DR BETHESDA MD 20814 francis. Coll ins.