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4o"5!

, 1*^S;fffi,ffitr BoSic Scien@

.:
Skin
bvh -
cutoneo vJ
15'2}oh dori totot betp+ bodon -{'t
B. -,:'

/jd =

- EPidvrnis mrrnyr: epidernnl


- Derrnts )
) ridge d6n Epi)tq derrniJ

- Hypoderrntt / rubcrr0nqrvl fiJ.rvg

S\Ed pore

Ep*rffiEl ri4s
Derrnal paparla

Afidor pim nE.Gcle

Sebco6 (og gnd


Sh,Bsl gtard dwt
[trerffiine sral g[and

\enl
Aftery

fubcutgtcsrs
bYq
Adiroffi cofirednrs ftss{6
Hair b{icle Sn$ry A'alat ealsory
gctive Ussue nerve tib6

EPI D R,M15,
- Jtrorifi 9d squomoui xerarinized gpithaliurn dengon re,' ,<erqtrnoQrg
- Adq 3 jenis rgl epiderrnor lqin : melqr!ocale,sQl ' Langerhonr, merxglcelB
- merhbenlur ttricx rrin ( di ielopok iongon don xarr ) ,rerlo ihin Jxin ( di bogion tubvh ,qinnyq )
- kerebolon ihicK rBin I qoo- l{@^rn, thin 52in: 75- l5ONm
- Dori dotom Fe ruor, epidermiJ tergtrl9glll xerof ino(yto cPodo rhr'ck
t. Strolurn bosqlis
- boJoPhr'lfs columnor '/ Oead ksdjimcjis
cvboidorl
- rcrdopoi h0 midesrfios0m g
ul mengrxorroh re bosol
iorhiho
- +r@pat desm0lome ,l
hengrkAf,(on te brer@l
don te vpperJ1/,to re,
Uviog ltrAtfiGlfa
,. s

d cell '
d$driLbce[
BasgrE rt trrmbrarle
nucleoli , cyloplorrn oKhf
cec
,nq65i61esi r f{lomen
, ,(efOlin ,Ec{rdftg
- odo iovlo hombDoli dtteh/t
irrolurn gerrn I nqtivv m
- rrolih rherhbenJuk
ronofibrr I + resirt frictiorr I Strotun lvcrdvm
- bogisnlvbvh y9 poting -honyo rehliho'f podo +hickskin
ser jng terrQkqnrpl ,elopdK - lop'Uon tipu,fanslucenl, rerdopot e(tremely FtorrenBd eojinophilac cefJ
Kori memtl,Kr Strol \rn1
6plnos'rrn tebOl dgn bnyB 5. Jtrotvrn Corneum
+on of i bv i ! dq n desrnosorne - 15,/d 20 lapiJ n Flottenod, non nutjeOl sd kerqfi ni Zed CellJ
O
3' sir Tlorysonol
- ,(erohn fitomeh, morniI Ki >, 6 porupeptide pg berbedo

' oPot rroto -


hyOlr ne 9rOnUl95
- Ado larnelbrgronules !
erocytoJ'ts {
mengeluorkon
lipra-.V9 berperon Olm epiderrnot
borrier
- Jel'Podo ep)derrn'E :

), Pheomelon)n ( di rornttrt npgroh)


rn bo3oJe
r ho , idk odo dgmojorne

JE
w TyrOsih
I ryrosino.e
3' u'dihgdrolgPhe'nyloloni ne cDop A )
J
Melonin
J
ArurnrrloEi di gronule yg di'rQbui melonGorne
J
ffansport vio xihesin Jeponiong microiubr'|9
J
0ahdril melan ocyre
J
lYohJ Port vio dYnoi n 19 huOlgvs
J
AQleose m lonerarh e
J
t n cdhoSo { Dro}exsihw}o. fivr
ori sbg t\)Ptonvdeot c(tp
Di xerorihocyte, okurnvl ffiXal8rlii"meru'eborlo
\. rahning lwl 2 PToJe( i
- reohsi'erjodi
pny si cochem i co I m enggglo Pr1 oh prce s t i ng)[ne,o ni n
- melanin synthsis don tronsf Qr r.e xerqt'nocy'er ^i (?
t odonyo UV rtnggDor-n ;91'6li'lrocyl! mertsQltejakon f(trror: porotrine -o Silmutosi me,ono(yre)

;gnot Fodo dedr,tc ceur don rdntriiBerre6pon imua


ilos odoplif
'(u,ri
,. IOCtile , *a7xg1cetU
\. rnechdho.ro(epior yO mirlp dgrn pdle-srdinins xrollrrocurg agn xeror in-)orngll' d, cyroplqtm
\. chorocteriJricfoorue: neurqrecretorygronuler beriJiPgfides'Golgl'df,\veddt}rE.forp'
\. tetox nyo di boJol epldgTDql lqlrer

DERMIS
'
w GonhQclive tissu ,9 rrensvpporr Ppidolmis don fiensittotl7n hwode/nu'
u pcrmuroohnJo irTegu|or dsn bdngdx proygr.li (dgriot '(e yg lerinterdigito'i drn lfoyeFJr epidgrnrl
popi,loeJ
CePidQrrnolr'rdge )
\. Terdiri
l. to lopiron l\ror)
i&tttffi1J:till"r?rr r.
d sn ti bro b )o5 t. m o( r c e, t'. n o* q hose

- rerdopof ,oJement melnbrone ) boJo lornino dln retiadqr,ornino


- odo onchori n9 fibril dori (ollo9n type Vl l. mosulr ro bOJo, tamrno'
mehgiFo, dermE re epidQrmt,
:. - iobihreliculorgbentvx
uopi$on C topison dolom)
febot, dor ; fu regVtor dgrrs conn ecf, vp fl rJve L bv n del t Loll ogen ty? e t)
-,ebih Uony-oh giberdon,ebihsedihi, ,tU, Oori 0opifiaw 1*",
\o permtj rneruporo4
releDor
- Et[cJor ngfYe : po
- JehJory aPPered n 'y 4oh tokrtorhoir{o[icJe-

HYPOg[ffiI$:
\. ,ooie conneCtiVe liSug
w bqnlpk Fat (Pt)J
.r eXteruiv vo5lulor r.rpp)y ropld uploke tolau oboi dii rUeksi kqn ke,,'oringon ini.
-

VPss15:
u a mOjgr plerv, : (u/ nvtritive f.rnr,ri Ofl )
- deQp podq interfoce ontoro hUpodermiJ don de/rnjs, superficiot drqntoro DaFillo,c donrtiqior
- ,vbpopillqry ptsXvJ
v v/ |hrrr)oregutql oru +unclion: onosrornose qrteriwenost dionlalo plexvr major

: ffii::h*, iLH? i i$,'li#


:l ii:fi;:fi [8l,llii
fr'"Ty I E I
(on6'1on, o odv terrlrohrG,
SenSory recep?otrJ :
r ilnencopvldl 8d:
. roclilG rJisCs ; vl l,ghr'to\rch
' irPe nerve ending; vl hi$hqnd louu ,e'nPgrofu'r' Po'n'
itchtnl
- Aool hoi(plgxuJei r dgekJ, pergerohgn rornbvl
r. Encoprv,ated ctocft)e meahanwecepor )
' ra.lile @nNscje CMeiJSner f,orpus O e ) I

\ eliipr t 30'l$ Pll


v regik I unru epl d errnjr dt derrno I po4ifi oe don opi so o I

popit)crfu podoiotiz, plopdx iohgln don xokt


\ detekSi lighr io\rch
- lamenolod Corp,l@t (Potcinrn corpvrder
..Qvol ,0r5-t mrf]
w dl reric^rlardermir /hypoderyniJ
14 v/ coorJe lovch ,presSure, vibf0riOn
li*lr$ @r$le
- trrovJse vJrpvsde 6f6 Ruffini corpvr c,e
\o pr Ssut! -seruih g rne(hdnore Cq, tor

hidenYol Denvatives ( Skin


HotR
rotntui = pilv-r
- io'tu heloi
rEIL
- iigojwrlsrornbyl: - @gion rerqr podo io i , xetohn Podo)
\ lorugo < holus, tdk berplgmen , lut.h i(er,-kq lqhir - u/ melindungi bogianylongjori ygWrsifal lvnoh dori trovt'tfr
rylekonil<
v l -o rO m b\JI utd mo.rg1 rrno n' d\rP, pd gxslrErnitqJ
vellv
a"ios don bonaeh - dsrlvot strgturn corneurn epidermir
* ierrnirUl |riir n Xosctr, fsrplgmerrloJi ; pd lQrrlO ' Oli,t , - bogion,(uku:
bulu rnolq v noilmatny '. *n*6gr,llt nail p)aie, Tunvela@ Sf,/,@

- \. no,l plfie : letdiri dan nott bdvi nail to6S' 77ee Qdg
pd moso Fvbgrlos I tonninol hoir menggantiron vellvJ
PdoYillqdon PvbiJ rm ondrogen - rvil body,. ngian KuKu Wwotm pinx
- JTfvX'hJr rornbtJt : shojl ros, : Rrianam dlm kuht,'ldK {'f/lilro't
.o folrkgf rOmbvt { invogi norl epidermi.t \. f/ee edge | ?onng diltc/l , batwQrno pvh h . tdk Jerd opat xaprler
* hoir bvlb * ep,?el h'tdJp yg d*elilthgi rambuJ lql rr lunvlo : prc, I Nl dah Nvkv
BoPtua
\. r00l I aKo r < dl rn foh x el, rerl onom dlm h pi,ro n kvlit v ?oqldrtvm : oetdh Ke.c l pd , ntQmoru-ortg
bolos nail
hinspa noit bctdy ^o11
'o s h of I * ro m bul yg rnemarj q ng hi n gg o xglwr pr rnvkoon, w htpongchivm : penebdan srrarumcnrneurn
rcrdiri aari oulA :Aide ddn jnner meduDo di qivog
- rerOopOl OnCior pili rnLlJ<,le .o Fukv.
menyebdbxon romb\fi berdjri
il okan
ot dirptin, vl
r1.oP wqrm air di deficlt,(uri, ) nertn-ding

SE8nf,hts crreno5 swEfrrGulluS


- podo dsrrnir podo hamplr.re/Uruh pprmulKc.crn fubuh, xec,urli " EccrirFsvil&ldatfi
relary tanganddnt<(,Ki. v poling bongqx dl i'dopof kokt
- )ronched ooityr flards, rcupper porhon dailnr{dltde .. odo u(retoG, porl,on don dugl , xedvongo (ol)d don &t lun:F/n
- prDd_uxsi JehJh vgterdn don wot QslwJ t2;olD), Joualgn Keq,
t,suL ), cho losf grol esler.r ( ) % ), tng s Jeclefury m: c,eaf col,J - Ptods!il hen)ro!
L,cg/ide a 5l "1, ). dan
pg-,)i
choleJrerot (, fro ) 4qlAcells
- se,<rpJi ,reavm O sool pubefio! < lwgaruh+es+oJrcrcfp rnyq4hdiol 69/lr -* ronlro$t vldttcloryn
-
Podo pno. ondrceBn P1@won;rq
Je!'vm + ul rr]@,ntra ioJffqfum cofnwm, romb.ti, da1
t ,yt?o, on: Ttopisqnochphi)ic l\i?&iwlrhr
v obSotb ion No+ v/ rrrch6pg6h Xeirg/ngan
fu ngsl cnti bo<.1ri ol - ant i{ur\so) eleqtbli"t
- FOKIoT y6n9 rrhgKItur ururcln reniar aan prOdvXSi .febufn :
w diry.ra7sln cholinegic fibvs
" 6ndr09n
C0HEAJ ) 4 mehingxorrgn . Apocrineuwoat flond
o refrnod i
mehghqrnbrJ )
. melan0c0f6n - rneningkc"KoD gilatr o n tcle t tebih besor aori exrine
ffi;u .*; grol\f sroro? q cti /ot ed Yece*tol { m Qn t n
re,hoftno)e
"
' Fibro DioSJ lrowih lo clor recePlo ".ffi r " tuidc') ' eorinqphlljc cgtb
ill';:ffi \0 diporrurqfi odrsnerBt c rerwhi ngs

7. Functions of Skin
5eCsro urYrurh . ?vtllSt f ulil odolOh uptUK:
'Prorchli fJbuh
- pehg olur s..t hv lu buh
- intorrnosi iDsorrk
. ekJKrSi don obsorbsi
- rnen)ctgo Keseimbongon coirOo
' rnehjo 90 berot ,\, b uh d) rc,opok tonguh dcln xori
-perborkon joringon i rrround heoling
Protksi Tubuh Ektlresi dan Absapi
\r Ruti, = rirsl ljne of aefenre \ 2@ ml cir dlm benhrk kgitgdj <IreAeritsr ps hcri
v melindvngi fubvhdorj: w rccrndurupn kvingaf: ttaCt, C$. r*lr . rE
-rotklrnro - olh rerdtin (memuvoJ eptdermis m.1U ., obsorpfi vJ vitamin A,D,E.K. 6t, (02 , obattpirtrJrEftil
imPer{neo ble .)
' rodiosirnCrlOhsri + oteh mebnin (meDogqqKrlviloj
Olrt A pd teroinocylo )
- inleb, - oEh Longsrhqru ceDf \o filogtDre t lCerboboJrld,
l, eldetmir memiliki.irtprnoniiohJidon entyrnohc don \a MsEiardng fipiU, T,Utein.gucot. podrr eff3d65,
no n- enryho ti c outo kod or p H sel m bong vg terbgtfvu BesoimD onp h dtiuan, uhrh tl? ftg!3p, arli t lll gpJi r
dQh osorn to,\iat pd xeringal, rneloboli, rnicrob)o), don
ssom lernok beasl .Jebvm

Thermuegulalor \, Jet. kulR rnensihtpru vttorrfn Oa


- Y rehDil(tnepgi2
dan pembp*lt&anlulshg
\ ponos dahqntorlon d9n rondvxli ,ne|d,ur joringon don
rcnverJi o,a1"' 6o roh' di mono panot avan rnv,gqlir dori
Joringc,n 99 Nnqs re,)<rrinBlon dgrr svhv lbh rendoh . Jexuol lignolln 9
'" se(nro redgFhono : rr Frr*none dpmduf it opDcD'neJw@lgbnd lwnjait
- pengeluorron reriryot'{ rneni^grol eaot pw:oJ - stttacl
- alirOn dorah re xuLt vcodihlali wql Panqs
-
hforrnqri Jensorik
rogsongqn didopof do, med(q ceg
?i;yffiix3:"
3. Norlnol Floro of Skin
r + populosi Kroorgonirme y0 datemuKon turnbvh podoitbvh orgng oehol
Nolmql{tOr6 mi
o6pecie5mrkroorganiimetsbrnendvdqfiBulir,muKoJom0rnbronP.6anfempot hoh-sre/i,elqinDo,norrnolngrrfonPo
rnenYe bOb ran PenY<rKit'
. oisebulJugkl norrhal rnicro{loro olou norrnol rnicrobiotq
. nlormol floro be.raJcll dori lodobocjllvr di vogi/lol *racl yg ditraumisik6n k n$ttborn r dlggrJivt troCl .
' NoYtnol 4Jevo ierbogi rnid 2 ienif :
t. ReEidQht floro 'o selqlu odo Podq iubuh
2. TronSiht florq - tinosal dlrn t1,bvh sglomo beheropo Periud, lolu dpt Eerpindoh cternporer- alm xen611,ierrenfu)
. Hubungon ontOrq horrnol Ooro don manvJio /hort:
- simbiosi, : mutvoliJmgr cofifirQnSoli.lm, PoroJirilm
- opportunis : podo xondisi normo,. tdl menygbobton penyoxil, topi poao rondiri vg rondvsi{ dpt rrr[bobFon
penyoKil.
" PQrqr'Qo rpsrdeni kcro: l mencgoh rdonijori pofhogen don rcnyotft rnetolr.li;hrerferen(e.
ueKanirme intQr{erpnce : rohpgfiri Tpceptor donnvJrui. muluor lnhibfion oleh rodur DQtqtrqlis.to*r'n.dop
ontr-brolix r bo$e riocjn
" roKlor vs 5grperoh dlm lYihgetiminosi non ruJid ent tniKroorgoni.rmC , pH O, Fotlg ood tdseDvm, odenyg lSo?rme
" Ternpot -Iempot qgfrnol florc di ruli, odo ? regf6n; oxrll o, periheurn, .itri,

[;#;H".h]."_i'
' Mlcroffgonism vg rherurolron normot flor0 KUlif :
r.r Bo(f eri : Jlophv,ococcuJ epidef midir. J.ovreul , Jirepto4gLLvrsp., Proprionrl2gltgrivrn o(/ne5,
rvllcrococcur rp . 9i ptrtgroidr
vo YuJt I PilyrosPorum
-. u[i es i Dernode i JP '

\. ?rirnorg ond Sercndong WSion


Pr.irnor [e si on
olh lgnYoxa, )
\ hetotnon B vg porrornq ferjodi (lecsro tgsg dtse,bobhon
xul
v JQniJl pr'fnorv leSion :
r. .oscvro < bervpo pQrvbohon t,ornq , oda y9 hyperPrymehred , hypoPigmeofed, dePignehtPd, erythernolou.,.
2. papule * nenonjot6n podot di otor Ferrhvhoon Kuli,, bqtoenyo regor. diorneler ( I orn
3. Plogug { l^vmp\,lon PoPvlg ( bergObvng) ' Penompc,ns> tcJn
q. Urtico -n edemo seternpOt y9 timtvt rnendodol don hilong perlohOn'?
5. Nodus - tYlo5$O podot, ciroumjcribQd, ,etoKnycl di JUbxulon,nenonjol' >lcnl
6, NsdulrJt r noduj dgn 0 ( I cl"r
l, Vesicte t pgtemlvv1g beriri coirqn Jervm ' 6 < tltOn
8. gullOe * wticle y9 uxuronnyq lbh beJOr
g. pvltvle * VS\cle U9 Ue.mri Pv5
lo, CVS; - penonjolon di oroJ permurdon rulit berupoKqnlong beriri ca;roa,,Jgl,otouJi(o rO
..*f f+fd firn I ieii ot-tl t
*F-er**+r*.#d's'qg
\o ,(ehnjUlan primOrJ tesion y9 berutoh xrn lfvjes p1lologi.t ,lfQvtflQ' olOv Obal
\. .lehlJ. Je@rUoo, leslon'.
r. .tsvsrno * strqJufn cohneufn teftepo, dOn rulit
2. cruJlo - coironbadonyg nrenper)ng,dpt bgrvpg reroJo afuvdoroh
3. Emsioh jonngon trilonglrrpifdk metqrnpgvirrrolurn bo$te
-o
l. ?rCoriqtlon .o xhi)ohgoh rqringqn ernpOixe dermot ppillae.
S. ul(er + hilongnyqjarlngon yg lbh dalarndai ex coribtlon
6. Jcqr -tvmbuhnyo joringon Potvl, pilo monodolqtau atrophV
T. febid- hgperlrophy yg Prfumbuhonnyo melebihi ta+oJ
8. *btcerl v ronlong .tens j hohoh<llrnjoringon
jelOJ.
9. Uxe64inori .o penebql6p lcvhf .rehiIrggo gafisz ltpolon /re[ ol ru,t} ,Lh

5. Acne vulgOn S

oeeinlsi ygbiota
ttogrnrit
.
. i(loinqn inft nd HiJrorJ,tdKrlgdon ?E
irletqk podo , dodQ'
ng * odo lesi (ttmedonpr 'Pvsflte' POPde '
. Jtf -limiled, leJ; PolJmoff ^rpuron
nod\r,e)Pd olnv &dO
'h;i;i'Punggvng'
+ermojuk romedo popvle'pvrfule' don nodulg'
' fdfiOlqgicolfrndmg
'
E1iot"ey "" i*H'fJ.H{,3$:X}'l?J:?+'amrnqrioo
i Ueffi,ffiffi2#''''o^'
. fogmelik . PeKUOn \n tCaffi}:,g
n M61ltdn o Eetoihon endoKnn ,. Lob reJf +dX dion,Jurlqn rpcuolif,utpedhy@randuogen
o gJeKon rneronir " Jltuj "o?neffipQrburvlrrojq
rt ^.-.-_.iriat OiafnOSjf
@
.-ffi -. /,-mr.^h
"cuoca?onor nembob w;l'Jt:'J'X'
foniculilrs
\ r,,n, tenns
:f*#rntJi&do^ornr,;, " ifl#l ,g
J
Jr-vpvr-miriais aister^inqtv'r
\?JeniJr ktin a1.11.?yg :

GlOSSif iGAfiOn - mpco, o(nB


--fr?,'Jl'X*
rrecrrolicp :,',f"'ffi[':::
'oc/le rfiecan|co
bentrr lesi aiboei.ro!^: - excorldro d ocna - ocne sfen,d
e oslta opsli\,oliJ
'
,. Acne vvtgorir comedone n plvg r0rofn dlm - qcrle - 4619 -indvced aene
ferbemvF pusiulP
folliouior agn ervth erno ddn '
* '+tdl)edthdt tf
cnmedone closedz,'rriieheOd
'{ ;HI:fl:',J; -' -h
ri'i:::,:,
bei"bentuk -.,r,.---
ro sc,Frilre 'ie 'hological fffwt+sd('inogsz
r. Acne wrgdris ,"r"1*rr*;;.-;:;r;gl'u.;
^-...1^ eryfietnO .".tr dqn
.1.t6 ra pru{1 orna*arrr
erythemolovJ -eStggfn Q)
poPuli, pvituto, inocvje ^E.r-hA ,tcor,
.
'"
wojo h Dprm,nydK .

3.Achewl9c,nJrcdulo@utrc-lnf,gmqJithenyebobxdn@
nooute dqn cJrr .n lccah - nvQh. I
^au6..,? L
{ nembpsor
dlmrorgf! a.-9:
ffi;;olnl';lri popuio'puitv,or w henoorer.i ior6 olfUiosipolo xe;ct}niJosi
uenoiJ - noauior,yStii. v menurunrgn arfiufaS.regoc@uJglond
r mehurvnron populoJi ?,Oche'
Glinicol teotul ',u memrroduiri efe,( oni'infrlarrf.si
t. tocol Theropy
onJ sile r w{oh tlutlB$lt$, dodo' Donv'
tlutrB$lt$' dodo, or
Dohv' xolqu di \ooeqhJing
bodah+ ferKohrentfoja dt deKor mldllne rr ropicOl o9ontr : rgtinOjd (tfelinoin,tQTarotehP'
odqPcr'eh^)
v lehrr lesi: onn -miuobroil t UentO I Peloilde'
c Noo. inf lomm orory: bmedoneJ
httoto erylhrDmyun' chndolllyan)
- opehcornedoheo 0BahelevoJl .worllo
iZct itotoiipoi'. 2' Jvstemic rheropg
- closed ornedone - 09oX eleVoJi pv.ot,dome -
, \o Anhblotic & ontiaOcf eriOl
Jhoped,tdrodo lvbong vtetr0cvclin0, erylh.romJcjn' doxycgCline,
. thflornlhofory -+ popv)e,7vsttrle, rntnoCycJin ' clindOmyCrn Per0ro,l' ofnptci))in,
a6dvl tn rnetho Pn m- surfo rhe. tnolq ?o)
*':T:g?Lil
Groding
Y #;ycohfroceptivpJ, grucocorriroid'
w E"rl'osn'0rol
cnBH agontJt' antionofuign' e'iiyme-inhhiior'
lrhe^cqr
NurhelCql :
:
) 25 - , -.- \ ar
, : open r <Josed compdo 3;: pustv.lor
nodvlocys}ic \'l -.-:'o*rinoio
t.'. Po?vlor ) r.g tosi { oiet
phyilCqt theropy +jgrqng_
Sevenfe v:cnesurgQ[9-iqtourcropi dgnobo'] lotDehhc/lil
mild * tdxodonodu)e,beberopopopvlotPujlule -'lntroleslondgtvcocorxc0'rd lOiectr0n
61edBr@t { beberoponoclu)e,banvot<;;;'t''p*;'e
severe - bonyoK hod\,te,0o0vrE, rullule enoono$i3 * boi|(,resolverponrsneovrle
6,. ?hqfrnocglogiCanl Properlier of ecng VvlgOriS' freortfnenl
Irgtirroin creoln Bentogl rerD(tde
." clo53: toPicot 4cne oge^t v CJa{5 : qotboclQfior and ierainotjtt gc9eil
q rndiccari 00 : {gp 0ch9 vu)gorls X FrclQl wnnKgt *rndicqfiOn : tuPiccltreqlrncnt For oq6g v,.tlgar^l
\4 conlroi ndicati o6 ; hypersensiti vit g .o contraind igl'taa : hype^nri,
v,ly
." AdrnlntjlroI on I opply ,o minvrpJ oflr sKio " Adwrinlstrqflon: qpp)red dlto rhe k*tUsrn r .6151,
is cleonsed ond cornplelQly dv)ed nnjed yJerfn
t9
\- h 6rrn a<orin gtiris : qbs ordfoa' FlOlAf dndsEnr! F+.H
Avoi d lips 9, dir961ly under e90J , ols0 uV erp "
P
r; o','i olrr (srr uo.l -
* Phorrnocoldnerc; rninirnolcrbsof pti 0n , ^
rnro tr.'1ococd
ekrcled
vrro\40r la*n'a *rl rvr
Mo A . ihhibir-s tnicrocomedo&nnot)on '+ MOH , redvcirlg
" $lr.in
decfot je J corrBgl y969,1'l
in of rerAtjnocyr0.J
_oAof! rcm7yal
turnoVe=rond ^rrfiJ rsl pglng
qftli 'o AdV60 effecf, drvnesj, ro
" Adve[e eFF heg, eryrherno, /SL ttn1" )/l
itvr, hvpgr/lUpo - twrcedolY
Ptgrngnfoiioo , OdE mO i '
'{ Dosoge i oegi'nthef6Py* 0,02506 ,6.2am/ o,Og% ,0 /20'1. ) / /
mict\csphere sl /o,or%sel , ihh
cfronger. we0k 9f t\eropy
dosags r:

Dorycyclin e
\ oqs, \ +elroLYdine ontrbi oltcJ
"Jhdicr^tioh: booleridlin fecrlon , ulemi.ltp; , bvmps, ocne.!iF lesion
-+c,ontroindicqlioh j qnoKr (8 +ohvn, pel'sfnilon , tKxtg11i, lrs,perugn"ritlvify
.+ Admihiltrdtlon
: 0rot / IV
\. phorrfloc0rinelicj: qbJorbod dar\ Gt
troct .pfbtefn blndihg Bo-gsolo,iip)dlolvblo, inatfivasi ,dt
ttuer,eKjFpri
-, iq uine
"Jj;',l:"[r,r,, ;r;;;
MoA : beriKdron
1.t'rrl _'",*ro,,,nnnbrq6 3;11
don orsanisme
: |::il'3:ifr;-;'i';S'tr',[T:H,",,J^'J1',9:*:;:ij:iii,t'j"#,i#H[fl,f,fi3i:
7. Irrilont Conto(i Oermatitis

lnf bmos xslil J9 non-irrvnrnologic, disebobko 7t . Ecl.emq " Mrlioho .Alopci


o
9!Ql rontox d9n agen chemicoi,physicst.atou . utcerai 0n o PQnubohon pigrngrrfoJl . uriCono
biologil ' Diklojifrkdsixon xe oorbri aoJenovJ hyper/hyx:lptglrrrlrrqsi
derrnotifis ,
" Follicul'n J o GrohrrtCrfi o

, i-clKtor eKJogen -t irritqnt don langRungon Jub.lactiv:


o rqrqKlerirrih ex posure .. vtoJor
" Ioftor lingkungan + ru[s, retembobdn -onsgi symprDrn wtlhi n mlnuiel -hours don clposu ra
' Faklo r endogen { genefik , ggrderr urovr - pain, bvrning,sringrng , ot(u drtcom{orJ me,lebihr iichrng
ro Mingr
- onsel drrylo*iiit wilhin I m'r nggu erpoSv re
- 0onyok 6yon9 di {Ekitor ju961 nrengolaml xot yg sona
o xOJmEfik . rnotonon
o$eoivB
. en
DgErg . reternhoUon@ :
.o Mojor
" D.rJtltrjcton
:
o toplcot rnediCoti on - moculor oryrfremo , hypenKerolo5\l , <ttou $JJut)ng
- rl(tEd, porch Pd.Jcd,ded epi de/mii
- p^2.(pj pohyernbvhon muloi poOo withdroy\roJerpoS,rrs OAn ogen
y9 menggonggu
" Acute irrilqnt contc/Lt derrnotitlj - pqlch lesrjng -o hegotif
" 0elqged ecr;te lq,g .o minof l
' Irrrtont reocli qr
. Lhrohi( IcD -.rhorp drcvmjpecfioh
- evi6p6.t d6fl penBorvh grovttolj spI Efek droe ptl\g
' Trovmoti c IcD - xUr0n9nJo ,ehdenJi rr, ,,nehJebOr
" Acnei(orrn Ic, - ferubohon morfiologij I conto(}liroe rne?nplpdukli pervboho nb*<t
' Non arylhe rnalous tsuberylherrqfovj)
irritoti oo
' 5\, bi ecI{ ve t5ensorY ) irrito"Ii on , qliergrc (ontoct derrnotiri! "sriDrolderrnaiiiit
' Frrclion dermolilis v exclude dgn.polch tpsl ylo pIp 16derrnOI1J
. ph
" olopic derrnohllJ .5p5e11holc dermahJiJ
. eryfh efrr, th FQcfioJurn

r Momaroi noiecnW crolhing lb(rrief Lredrn


. (olou udo onto(, dyn ogen pehyDbog, cuo l glv66qorYlcoid
dgo o\r / nreo[ neu*rqliting Jolulion "r A(rrJe : nemg\re efiologic ogehr,,fDpi(ololoSS /
qchronr: topicotglucocorlicojd potnr.pt biomefVrosone4f rcp cne.
clobeJololFroptonole, dan ltrbfrkoli cao creom/ arnrrnsr
E. phorfnocologi@,t ?{owngs o$ icD' rmtmen+

I rftcafi c./a'd \o cla$ I @rautgfic and dejf ructi\e 6pen,


b rn mol orJ 4io nt'' f D Pi ca co
nD - i rrf
Kulif rednp'
: cohlo(, Oefinafirij iollerint firrilant )' qloqic vtrdiia]i ) hyperrcrotuit ,61y6st1' p,torioJit '
defnai.,)J , soDorrl-eiC ded{fl1it'J ' Ptorialis ,cqah dp,nbeBrik
\o fiofrlmindiXoti I hyper,reruif ?Otg s con+loi ndi @ti on : Ptagno n cY
." Rdminiltro si : opllv podoatg vg re\,finggr1lth'rub in e Aohiniclrqr : oppty po6aKNlit ys wengpruh
gsrrb donc.omplellv v Ph a1x6qc1o1i nqics : mi ni nql qbtoffh A, disn bv i di
u Pho rmocotinett cs l m jn rmt qbJorprim, wrJ -h igh fIJto@llvarsrye, ersktasi di uine'
i
elFico cy
* Moff : mening(ot lon 4q6 tlrofutn comatrb)
v MoA; ) Fu ngfli rct ofifu^plerq)rg^1
b &n rete,nb vr, rnahgq lteta',
Kerain cEeru1flyfis )
., Mwrse {fect : p\rnting, ni n gi n g
mengvrcno permeoui lilo.l drd/ing kq/ilv don \. ,ajoge t 2-2o% cteorn /lohon.l-lxsahdri
PerrDentvroD odgrno.
b Adrerso aitr'l t

v DoSo9 : C/pam /
ernollienl o/Og ob, u Jchorf
g gHP, ?tlo?,CRP
OH? PH OP

ogn e+i cen ce, non' molQfi cencP'iusr


ice'0 ulon 0m9 . rrornoTihg imponlqnce o{ penonothJ,gjgne < woJhin$lOc
'
. cr; re ond cor ' Educa+r ng ra+ional ute ol dru%
Prornoting qbwl occu poti onq I contqcl derroali s
' elploin medic.ofiions given deorlv "
' m{ormed consenl be+ore Pqlchrcll " PrQvQni ICD by hporing profecri ve cloll'tgt
o civEruggetllon; rnodifg wortinghabil or cMrEQ
CRP
.lb ;
" Folloru -vp o Acfl vuJg0DJ q ?}',t" o0 yr,ungpeop'e,Jeverp ih mole - Dge of o^te+
. encovroje pqt'Pnt 1o hol loing self- irnogel evD9rly ( 10'tl Y-O ? , tY-t9 Ya tl )
self. esteem . trCD -t {,5 / p -o@ di Gernshy
Cose Revtlv
r{5,D9OQSrl9Y'o I
I o9O
cHlEt @MftFlNT: comedo n65, grsrlhPmoiws IoPUB , pinlvl ?!5!de5, scarS onfoce since ' !qrj

qNArvl Nt5r5 PH}sI(A[ 6XAM t/l.b ElAl'n


- comedonejdndpopuloj WofP rgcurrehl . e? fi ol olo giL O I tt otv t
, O
' ororn j Jto:,.:tir]u Crctn Nsivle;
qppeorPd becorp rnensfrvoli on -oifl)bulon r rpgione/
h0 ca6ge5 I bocilli
_ - Locofion : pce adbth Polrns
on Fqcg: * roH exam trompolmt : no
chorocrcrilfits of ,psion : m.rriprc, drcroTp, hyphae /cpOrpr
1-rrnm,ercvored, dry
dei0gent rJpe ot,eSlmi torne dorE , eryrhemorowpoDtJ/g.
puJtUEJ fioduJp, g(orr
olrophiC,
on both polrru ,l

ch 016 6ts 7iI 1ic 0f ,ef, on : rnrrrip, e,,rsn e corVl u pncd,


2x1 crn - 5^3 ctrt, @vQl ed,
try
Tl PP o0 lesi K.olps,$ tsvte
on : erythernotu/ fi1ocvl 9J,

DlAcNo5ts,ffNEwtceFSlctlBohllcculh'mrluE Tl S
i l-P iia rrr Cor'lracr oEPMe Tl

- clobsl orolPIoponale oinTmglf


6o9. dayaid ntihrfor l wwk
- ro% vrco Ueom 3r dTilg
a5 gtnoliglnl

L.l
PRo6t..pst5 : A0 BoNAM
*. q month lafpr- comedcneJ ,e(lthln'rrlw; PoPuJ @, pvsf ure@
ro tlin of pdrns .rfnooth , rcole! f piOvrRO
Acr wlgnrtS
.r0ung o9e
MJ. Agnes , 19 Y.o I

unKno^rn in l+i ofi ing wclor andagglO


J
J gtsrl
,irmJt4re oclivtly of ,ebo(eo\, t
Allerallon jn *he remtini?olion
pailem wlth)n 6eboceouJ folliole J
J reUtrmleclghmO
rqu llg deseuama'tion oq follic,ulor J
onice rrigycerido on rxrn@
J J
Pl\,9 forfnofi0n P-qcher O' ' -
J
Comedo co rn p Jenc nt OChvotisft rnetotplrZPl
Jeggfe cherno - lr,gUcende
prod vcPs Proteole
+ocfic foctort J,
& hgolurodinoJe
j qnfi r.qmE dnribodff)
q+troc+ PMN
J
leuKocute neutrophil0
{ J
enter folliole
d e5tru ct ive hy drolole G)
J
rcleose tuarDtylc J
eh +gm e pro inf K Inmoloru medi olon
(.rt -a -l
J
Foilrcuior epiHnelio!
do rnoge

I
in{lorn motron
J
edemo in folliculor dl
chnicoldP&l .
otqr ,oru,n',puifute --- - -@
I
\
dirrended PtlicJ wolll b'Pol
I
\ J
,
- - - - I Hinolog!, of
\ I
conlenlsof {ot)ideederdermis
,o EpUrris r
t- \
inflarnrnqtory l' furogn bodyroiponre \ hrni,,
t \ I
J?r'Pod +o rurror,rrrdirg

I .l\r_ J
-- nodu)Q,
sL oF I
. Trefinoih creorn o 'ozs I *rurture
so(e nighl . , ^
[o(e ot niohl
I
JcOr for rnoli 0n - ..
benuryr ldrori
de gel Y'lo
oog9 night setondorg l,c$on
' oo-ry(yqline 21100 mg'doy

I
eMWnotologl, ot
medlcctimr
Ililall@nlorsl EllrulrIis conceo, Ivbspino

cootact ./defergehl 005,ffier, tgy'o g handt


J
dornqgeto vuoter -profein-l\pid
- rmfix o
of o urer byer of rKl n
J
.lrinborderd)rrvplion - e -- Furrlion of*in -

transeP\ dermol wqter loJ,


renhnG)
J
lager becomP rhln
J
drynPlr

J
JCAling
; J
-l_ fiJsudng
i
I
- -- Imtanf "f** oermahttt - - clintcat fis
I @
o.roSohd}v t ni$w for 1 wreI
I
lrpairnenl I clobotoso I pwpionote
Dol- ureq c?am 3/,
I

urio]l

Angelo Gro@
laoilor0066