Documentos de Académico
Documentos de Profesional
Documentos de Cultura
REPORT
Team InnoS
Ms Amali Ranasinghe, Project Scientist COSTI
Parallel Sessions 10
22
Special Remarks
23
Way Forward and Vote of Thanks
25
Annex
National Conference on Biotechnology
Page 2
National Conference on Biotechnology
Hon. Senior Minister Prof. Tissa Vitarana spoke on the different technology waves that are now
sweeping through the country. One of them being Biotechnology, has been recognized as a very
lucrative means for developing the countrys economy. Taking examples from around the world on
exporting hi-tech products Sri Lanka should also take initiative by increasing value addition on their
exports, which in turn will lead to an increase in the countrys GDP. Globally the Biotechnology sector
increases each year by 11%, and now it is time for Sri Lanka to contribute its part. The Global
biotechnology industry is expected to reach US $450 billion by 2016. Sri Lanka has formed a public
private partnership in developing nanotechnology by establishing the Sri Lanka Institute for
Nanotechnology (SLINTEC). Scientists have to interact with industry in a similar manner to achieve the
economic growth via biotechnology. COSTIs coordinating role could be beneficial in this context to
translate the research into rupees. This conference is aimed at identifying every inch of potential
through value chain analysis for this to be achieved. Hon. Senior Minister Prof. Vitarana then
specifically thanked COSTI for organizing this event and highlighted the role COSTI plays in
developing the biotechnology sector of the country.
Page 3
National Conference on Biotechnology
The welcome address and introduction was delivered by Professor Ajith de Alwis, Project Director,
COSTI. He highlighted in his speech a background on COSTI and the important role it will play in the
future on the economic growth of the country. COSTI was established in 2013 through a cabinet
decision on September 11, 2011 with the mandate to coordinate and monitor scientific efforts,
implement value addition, and facilitate the commercialization of research efforts within the country.
There are 61 research institutes and 24 ministries that need to coordinate in order to convert
Research into Rupees via making our research into tangible products. Prof. de Alwis further went on
to emphasize that monetizing the work shows the economic significance of research and will
encourage more investors to fund research. It was highlighted that the Human Genome Project had
generated $141 for every dollar invested back to the US economy. This exhibition showcases our
capabilities and capacities to develop biotech industry in the country. With a vision to increase the hi-
tech exports a VIDU Sri Lanka was introduced with a way forward for VIDU NEGUMA. The goals
ahead are to increase the percentage of Sri Lankas exports with biotechnology, make a roadmap
for the biotech industry, and to develop National Innovation Programs (NIPs) that will lead to
develop proposals for the 2016 budget. He concluded by saying, We are a biodiversity hotspot
lets make it a biotech hotspot in the future.
Page 4
National Conference on Biotechnology
Mr Rizvi Zaheed, Co-chair, Managing Director, Hayleys Agriculture Holdings Ltd and Director
Hayleys PLC.
Prof. Ranil Dassanayake, University of Colombo and Ceygen Biotech Pvt. Limited
He acknowledged the current contributions by the National Science Foundation, National Research
Council and the Council for Agricultural Research Policy. COSTIs aims through this conference are
to pick a few ideas to bring to fruition. Prof. Perera also pointed out that at the end of the
conference, COSTI aimed to establish the first National Industrial Biotechnology Association to
accelerate the economic development using biotechnology.
Page 5
National Conference on Biotechnology
Mr Ajith Cabraal the Governor of the Central Bank of Sri Lanka highlighted the importance of
science and how todays Scientists can contribute to the countrys wealth creation where research could
be converted to rupees in a positive manner to contribute to Sri Lankas US $ 67 billion economy.
Science can make the country more sustainable, as he pointed out by increasing the countrys exports
and decreasing imports. As he pointed out there needs to be a hunger to innovate, especially since we
are connected to the world and therefore must contribute our share of development to the world. The
21st century is especially for biology. In agriculture, increasing crop production is a necessity while
conserving biodiversity. To protect the environment and reduce CO2 emissions biotechnology related
solutions can be found. In healthcare, we can work on vaccines and pharmaceuticals. He also
mentioned that in industry we can improve energy production by using biotechnology related
products. The Governor highlighted the importance of bringing in more investors to the country to fund
scientific research and in turn the research can be profitable for both the country and the investors in
the long run. Although initial capital required might be high, with incentives and results promised,
people would look to invest more in to scientific research.
Page 6
National Conference on Biotechnology
The industrial exhibition was inaugurated by Mr Ajith Cabraal, the Governor of the Central Bank of
Sri Lanka and Mr Mahinda Madihahewa, Secretary to the Senior Ministers Secretariat. The exhibition
was sponsored by the US Embassy of Sri Lanka.
Page 7
National Conference on Biotechnology
In his speech Igniting Minds through Collaborative Partnerships: The Route to Creating Wealth for All
through Biotechnology, Mr Zaheed, talked about how the private sector can help to jumpstart the
process of partnerships and wealth creation. It was stated, how most of the wealth currently is
concentrated in or around the Western Province and the wealth needs to be spread around the
country. In addition we have to increase the hi-tech exports by contributing towards increasing the
percentage of hi-tech exports to 10% of total. He continued to explain private sector approaches
of fast track, environmental scanning, igniting minds, collaborative partnerships, and institutionalizing
entrepreneurial spirit. As an example; fast track means moving beyond talking and into planning with
responsible regulation through rapid development. He further went on to elaborate that there is a
brain drain where young educated people are leaving Sri Lanka due to a lack of perceived
opportunities within the country and why it is important to retain the skills if we wish to progress in
terms of technology. The biodiversity hotspot needs to be converted to economically benefit Sri
Lanka towards becoming a biotechnology hotspot. Environmental scanning is equally important to
lookout for opportunities in the market. The national requirements need to be addressed keeping in
mind the market needs. When agriculture is considered, the growers requirements need to be
addressed while attending to value addition. He highlighted the enormous export opportunities in
floriculture and horticulture, plus the opportunities in health care. Finally he emphasized the
importance of collaborative partnerships and that incentives need to be enumerated.
Page 8
National Conference on Biotechnology
Page 9
National Conference on Biotechnology
Dr Dharshan De Silva, Director/Senior Scientist, Genetech Research Institute chaired the Health
sessions.
Cutting edge Technologies for the Development and the Manufacture of Antibodies and
Vaccines Prof. Roshan Perera, General Sir Kotelawala Defense University
o Current expenditure for vaccines in Sri Lanka is LKR 400 million per year and they are all
imported from other countries.
o Antibody treatment is also available in Sri Lanka but it is very expensive as the antibodies are
also imported from other countries.
o Therefore he highlighted the importance of developing vaccine technology in the country, and
how it would help make treatment more affordable and available for everyone.
o He also discussed the potential of being able to export our knowledge on vaccines to other
countries if the field was developed within the country.
Current Landscapes for Molecular Diagnostics and Future Trends - Prof. Aresha Manamperi,
University of Kelaniya and Ceygen Biotech
o Medical Diagnostics is important for personalized medicine: The right therapy for the right
patient at the right time at the right dose.
o Current medical diagnostics in Sri Lanka is dominated by infectious disease testing which
accounts to about 50-60% of the market, and 99% of it is service based.
o She then discussed the key markets, the clinical role and current technology that is available
for diagnostics.
o She then highlighted the current limitations in diagnostics and what strategies must be
implemented in order to develop the field in Sri Lanka.
Page 10
National Conference on Biotechnology
Genomic and Regenerative Medicine: The New Frontier in Health Care Prof. Vajira
Dissanayake, Human Genetics Uni, University of Colombo
o He discussed the health challenges in Sri Lanka and why non communicable diseases are
becoming an increasing threat to the Sri Lankan population.
o Statistics were shown on patient populations for which a particular drug is ineffective, and
as he pointed out that the effectiveness of current medicates to any indicates range from
approximately 35 to 75%, and that no as a result many patients do not have medications
that are effective for their illness.
o He highlighted the fact that we are in an ineffective health care system, and adverse
reactions to drugs are one of the leading causes of morbidity and mortality in the world.
o He highlighted the fact the Sri Lankas population is aging and that organ replacement will
become an increasing need in the years to come, and that there is a need invest in stem
cell biology and regenerative medicine.
o The solutions to overcome these problems lie in understanding our genome and increasing
our capacity in regenerative medicine.
o Prof. Dissanayake also pointed out that the current economic impact of the human gene
project, on which 14.5 billion USD was invested, is now estimated to be nearly a trillion
dollars.
Pharmaceutical production: Setting up facilities to produce off patent pharmaceutical products and
to gain experience in manufacturing under Good Manufacturing Practices (GMP) as both an export
and an import replacement. This will allow Sri Lanka to gain experience to build their own R&D base
to make new pharmaceutical products.
Nutraceuticals: Sri Lanka has many traditional products that can be marketed as nutraceuticals. If we
can bring this information to potential investors they can set up facilities to take advantage of these
products that are in high demand in western countries.
Especially Ayurvedic products are in high demand at the moment. If the Ayurvedic sector is to be
developed and marketed, proper standards need to be introduced to evaluate the products. With
Page 11
National Conference on Biotechnology
necessary funding we can prove the effectiveness of ayurvedic therapies, which can help in marketing
these products and expand production.
Vaccines and antibody therapy: Provide funding focused on research for potential vaccines and
antibody therapy for targeted diseases. It is important to build up capacity in areas such as antibody
therapy, which is becoming a cutting edge area of treatment for various diseases. This field has huge
scope going forward.
Page 12
National Conference on Biotechnology
Agriculture session was chaired by Prof. Athula Perera, Co-chair National Council on
Biotechnology
o Dr Hettiarachchi first gave an introduction on what a transgenic crop is and moved towards an
overview on the crop genetic engineering cycle.
Microinjection
Protoplast transformation
o In one of her slides, she highlighted the traits that add value to transgenic crops such as
increase in yield, improved nutritional quality and disease resistance over other crops.
o Dr Hettiarachchi spoke about currently approved GM crops and the increase in its usage. The
global hectarage of biotech crops have increased more than 100 fold from 1.7 million
hectares in 1996 to over 175 million hectares in 2013.
o Current status of transgenic crops around the world was also highlighted, including the 27
countries that have been identified as large-scale users of transgenic crops in the year 2013.
o Further pointed out how BT crops contribute to food security, sustainability and climate change
as well as its perceived downfalls.
o Dr Hettiarachchi also talked about the transgenic research conducted at university of Colombo
by over-expressing BBX21 gene in rice. The productivity of the crop is increased by enhancing
the light-signaling pathway through over expression of BBX21 gene in rice.
Page 13
National Conference on Biotechnology
Formulation of Bio-pesticides and the Mass culture of Natural enemies for Pest Management-
Dr Daya Ahangama, Retired Professor, University of Peradeniya
o Dr Ahangama gave a brief introduction to bio-pesticides, what they are, the different types
and their modes of action against fungi, bacteria and viruses..
o Dr Ahangama also highlighted the unique features and limitations of using bio pesticides with
emphasis on why there is high demand for bio control agents with the increase in resistance by
pests to commercially available pesticides.
o Other reasons for looking to bio pesticides as an alternative include: Effect pesticides have on
human health and the environment, lack of broad spectrum pesticides for many varieties of
pests and the ease of use unlike with other toxic chemicals.
o Some of the research findings she presented were from research work done in Sri Lanka. The
bio pesticides are not yet available for field-testing but the laboratory testing has shown
promising results. There is interest to take things from the lab to field and then to the
commercial market.
o Protein therapeutics represents one of the most widely expanding areas in pharmaceutical
industry. Majority of proteins are glycoproteins, and plans have gained acceptance as a high
quality alternative and economical protein production.
o One case study that was discussed was on the production of Erythropoietin (EPO). It is a highly
glycosylated protein produced in the kidneys. It is an important growth factor and plays a key
role in regulation of erythrocyte maturation.
o Using Biotechnology it is produced in the CHO cell line and is used as an Erythropoiesis
Stimulating Agent (ESA).
o Has a market value of estimated 8 billion US dollars a year. Its application: Anemia and
Cancer
Page 14
National Conference on Biotechnology
Biotechnology a tool for crop development: The aim is to allow scientists to produce more useful and
productive crop varieties by exploiting genes from a wide range of living sources, not just those that
can be found within the crop species.
As identified at the conference, the following working group along with other relevant stakeholders will take-
part in the proposal initiation.
Dr Chamari Hettiarachchi, University of Colombo
Prof. Sriyani Peries, University of Peradeniya
Dr Renuka Attanayake, University of Kelaniya
Dr Thirukumaran, University of Jaffna
Dr Jayantha Senanayake, Department of Agriculture
Non-state sector: Hayleys Plc., Genetech team, CIC Agri Biotech, Serendib Horticulture Pvt Ltd etc.
Improve and enhance the production of bio-products: The government should fund targeted projects
to discover natural bio-fertilizers & bio-pesticides and establish their effectiveness for use as proof in
marketing. This will encourage industries to use these biodegradable products in their manufacturing.
This will further promote the use of environment friendly products in Sri Lanka as well as being able to
export to other countries.
Similarly, the following working group along with other relevant stakeholders will take-part in the proposal
initiation.
Dr Daya Ahangama, University of Peradeniya
Dr Mikunthan, University of Jaffna
Ms Nadeesha Karunaratne, Biotech Lanka Pvt Ltd
Dr Sarojini Fernando, Rubber Research Institute
Dr Vindya Basnayake, Plant Viral Indexing Centre
Non-state sector : Bio-power Lanka Pvt etc.
Development of therapeutics using plants: Fund research to produce therapeutic proteins in plants.
A number of therapeutic proteins have been produced in plants to lower costs and reduce adverse
immunological reactions in patients, e.g. Recent Ebola therapies.
Also, the following working group along with other relevant stakeholders will take-part in the proposal
initiation.
Dr Nimsha Weerakkodi, Open University of Sri Lanka
Human Genetics Unit
Dr Sandun Senerath, University of Sri Jayewardenepura
Dr Pushpa Abeysinghe, University of Ruhuna
Sri Lanka Institute of Nanotechnology
Non-state sector
Page 15
National Conference on Biotechnology
Industry session was chaired by Mrs Sharmalee Wickramasinghe, Managing Director, Ceylon
Biscuits Limited.
o To make them, put gene of interest into vector (plasmid), then transform into bacteria (or other
expression system), the bacteria then transcribes it into RNA, which directs the assembly of
proteins of interest
o Scientists must choose appropriate expression system based on post translational modification
of protein (can even use plants sometimes)
o In Sri Lanka, only University of Colombo Biotech and Ceygen really doing this work. We have
highly skilled people but lack funding
o Biological materials are a component of a biological organism or something that can make a
biological reaction happen
o Bio-economy is the economic output from biological research and from biotech industries
o Sri Lanka should use unconventional thinking and use synthetic biology to make materials we
need
Page 16
National Conference on Biotechnology
o These initiatives will create jobs in various sectors, not just science
o Collaboration is key scientists and policy makers control the direction we head in the future
o Biochemical conversion of biomass into energy is done when biomass is fermented, which
produces energy
o Ethanol fermentation is when cellulose or starch is broken down into simple sugars and then
these sugars are fermented in a process that produces
o Best case scenario is consolidated bioprocessing , which means everything is in one reactor
o Challenges: enzymes are expensive, pretreating raw material takes a long time, Sri Lanka
does not have a lot of plant matter to use, besides straw
Question to keep in mind: How do we use these technologies while preserving Sri Lankas biodiversity?
Pharmaceutical production: As mentioned above providing incentives and funding to research and
establish a nascent pharmaceutical industry with R&D facilities in Sri Lanka.
Synthetic biology: With new molecular biological techniques being developed scientists are able to
produce a wide variety of products using various biological systems. Companies should be
encouraged to partner with scientists from academia and industry in other countries to enhance our
capacity in this area. Using synthetic biology we can then manufacture products that use less energy
and are environmentally friendly. There is a huge global demand for products that are produced
using eco-friendly manufacturing methods and through synthetic biology we are able to accomplish
this. In addition it is important to fund research programmes to understand the various microbial
pathways to make protein production more efficient.
Page 17
National Conference on Biotechnology
Enzyme and food additives are a growing industry. Sri Lanka has a number of natural products in
which these enzymes and natural products can be purified or produced using synthetic biological
techniques.
Biotechnology for green industry: As most of the industrial waste to be managed in an environmental
sustainable way this technology could be utilized for green management.
Page 18
National Conference on Biotechnology
Selected members from respective sectors in Sri Lanka, who exhibited their products gave brief
outlines of their current work in the biotechnology industry as well as their opinion and suggestions on
how things could be improved.
Page 19
National Conference on Biotechnology
Page 20
National Conference on Biotechnology
Open Sessions II was chaired by Prof. Athula Perera and Dr Dharshan De Silva
"Capacity Building in Biotechnology by Prof. Sirimali Fernando, Coordinating Secretariat for
Science, Technology and Innovation.
Ideas fuel R & D, which leads to technology upscale and commercial production that allows market
penetration. There has to be cooperation between industry and university to build capacity of human
resources, and the necessary infrastructure.
Page 21
National Conference on Biotechnology
SPECIAL REMARKS
Prof. Kshanika Hirimuregama, Chairperson of the University Grants Commission announced that the
University Grants Commission will collaborate in future activities with COSTI.
Page 22
National Conference on Biotechnology
COSTI will look through the dreams and aspirations that people wrote down on the notecards
during the parallel sessions. Depending on the idea, its relevance to COSTI goals, and funds
available, some of these suggestions will be picked for future funding. The teams established at the
conference will make proposals and submit within a months time to COSTI.
Page 23
National Conference on Biotechnology
Participants were invited to give their suggestions and comments on the COSTI conference. Some
common themes identified by this were;
a) Developing certain products in Sri Lanka instead of importing them (Enzymes and pharmaceuticals).
b) Discovering/modifying products unique to Sri Lanka (for export).
c) Developing bio pesticides and bio fertilizers, using waste to make biofuel
d) Genetically improving crops like rice and
e) Investigating the mechanism through which ayurvedic herbs work.
Additional suggestions for future work:
Use already available materials, such as agricultural residues, to look for unique proteins that
have niche markets one person has found coconut gene related to somatic embryogenesis,
similarly we can map rice genes
Genetically modify yeast with genes from cellulosic fungi, eventually making a process that
goes from straw to ethanol in one fermenter
Producing reagents/enzymes/primers in Sri Lanka instead of importing them (e.g. Currently
University of Colombo is conducted research into producing avidin).
Introduce biological control against white root disease (which attacks rubber trees) some
antagonistic organisms already found
Improve bacteria in fermented dairy products to increase the probiotic properties and
improve Sri Lankans health
Have awareness programs to educate other researchers and the people using the technology
(farmers) about new innovations and investigate danger to health carefully
Industrial sector should invest in university student research
Industry Biotechnology Park with services and all inclusive facilities for economic development.
Page 24
National Conference on Biotechnology
Annex
ANNEX 01 : LISTS OF INVITEES, PARTICIPANTS
AND EXHIBITORS
No Invitees Institute
1 Prof. Tissa Vittaran Hon. Senior Minister
2 Mr Ajith Niwad Cabraal Governor Central Bank
3 Mr Mahinda Madihahewa Secretary, Senior Minister Secretariat
4 Prof. Kshanika Hirimuregama Chairperson, University Grants Commission
5 Dr Kumara Hirimuregama Vice Chancellor, University of Colombo
6 Prof. Tuley De Silva Link Natural Products
7 Dr Mark Eiteman Keynote Speaker
8 Dr Sirimal Premakumara Ministry of Technology and Research
9 Mrs Padma Abekoon Director Biodiversity
10 Dr A M Mubarak Chairman, Industry open session
11 Dr Arjuna Kumarasuriya Asia Distributor Territories, illumina
Page 25
National Conference on Biotechnology
Page 26
National Conference on Biotechnology
Page 27
National Conference on Biotechnology
Page 28
National Conference on Biotechnology
Page 30
National Conference on Biotechnology
Page 31
National Conference on Biotechnology
Page 32
National Conference on Biotechnology
Page 33
National Conference on Biotechnology
No Company name
1 Analytical Instruments (Pvt) Ltd
2 Bio Power Lanka (Pvt) Ltd.
3 Biotechnology Laboratory, University of Colombo
4 CANN Biotech (Pvt) Ltd
5 Centre for Dengue Research
6 Ceygen Biotech (Pvt)Ltd
7 Credence Genomics (Pvt) Ltd
8 Hayleys Agro Biotech
9 Human Genetics Unit, University of Colombo
10 Lanka Bio Fertilizers (Pvt) Ltd
11 Mega Biotech(Pvt) Ltd
12 Sargam Green Tea Pvt. Ltd.
13 Sri Lanka Aquaculture Development Alliance
14 Asiri Group of Hospitals
15 Genetech
Page 34
National Conference on Biotechnology
ANNEX 02 : AGENDA
National Conference on
Biotechnology
BIOTECHNOLOGY FOR WEALTH CREATION
September 18, 2014
Hilton Colombo Residencies, Union Place, Colombo 02
PROGRAMME
09:00 am 09:30 am Registration
Industry
Agriculture Health Mrs Shamalee Wickramasinghe
Session Chair : Prof. Athula Perera Dr Dharshan De Silva
Parallel Sessions
Page 35
National Conference on Biotechnology
01.30 pm 02.00 pm Exhibition and Demonstration Next Generation Sequencing : A Platform for Scientific Research and
Development
Dr Arjun Kumarasuriyar, Asia Distributor Territories, illumina
Chair : Prof. Athula Perera, Dr Dharshan De Silva and Mrs Shamalee Wickramasinghe
Capacity : Prof. Sirimali Fernando, Coordinating Secretariat for Science, Technology and Innovation
03.00 pm 04.00 pm Safety : Prof. Athula Perera, University of Peradeniya
Scaling up : Dr Aruna Manipura, University of Peradeniya
Regulatory : Dr Vas Gnanam, Credence Genomics Pvt. Ltd.
End
Page 36
National Conference on Biotechnology
ANNEX 03 : ASSISTED BY
Page 37
National Conference on Biotechnology
Page 38