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1
Editorial
Future Neurology
Keywords
Alzheimers disease
symptoms
ndementia n diagnosis
nearly-onset
n
natypical
part of
ISSN 1479-6708
575
Editorial
The atypical presentations of AD are more frequent in patients with EOAD. Koedam etal.
described that a third of patients with EOAD
present with nonmemory impairment compared
with only 6% of patients with LOAD, so atypical
AD could be up to five-times more frequent in
EOAD [1] . Our group also described that a third
of pathologically confirmed EOAD patients presented atypically [4] . The frequency of the different atypical presentations of EOAD varies
between different series. Our group found that
the frontal variant, characterized by behavioral
and/or dysexecutive problems, was the most frequent non-memory presentation in a group of 40
patients with pathologically proven EOAD [4] .
Other atypical presentations described in this
series were visuospatial dysfunction, CBS and
language disturbances. Koedam etal. found that
executive dysfunction was more frequent than
behavioral changes in a minority of 270 patients
studied, and none of them fulfilled the criteria for frontotemporal dementia. In this study,
apraxia/visuospatial dysfunction was the most
frequent nonmemory presentation, followed
by language impairment and aphasicapraxic
agnostic syndrome, whereas PCA was diagnosed
less often [1] .
Atypical presentations of EOAD represent a
problem in everyday clinical practice because
of the higher risk of misdiagnosis. Recently,
our group described that more than half of
patients with pathologically confirmed EOAD
and atypical presentations were misdiagnoses.
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Editorial
Bibliography
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