Serracor-NK for Circulatory Support

Did you know cardiovascular disease is the biggest killer in America in Men
& Women?
Arterial plaque build-up, excessive fibrin levels, as well as metabolic waste matter, can all slow-down normal blood
circulation. A healthy vascular system must supply oxygenated blood to vital organs including the heart and brain.

Serracor-NK is a fibrinolytic enzyme blend that exhibits natural anti-inflammatory

properties, helps normalize fibrin levels in the circulatory system, reduces C-reactive protein
and normalizes both blood viscosity and platelet stickiness.*

SEBkinase-CV brings together two enteric coated, fibrinolytic proteases: Peptizyme SP

(Serrapeptase) and NattoSEB (our Nattokinase is Vitamin K Free, since it assists in blood
coagulation). Serracor-NK further supports the activity of SEBkinase-CV with a complete array
of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a
comprehensive systemic enzyme blend designed to support maximum cardiovascular health.*
Fibrin performs an important function in the body, including clotting and wound healing.
However, excessive fibrin can impede normal blood flow, which may lead to increased blood
viscosity, swelling, edema, pain, inflammation and more serious cardiovascular events. The
proteases in Serracor-NK reduce fibrin levels and improve viscosity and over all blood
circulation.*
Nattokinase Research - Fibrinoyltic Activity

In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1 Research
with nattokinase demonstrates that it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac
infarction, pulmonary emboli and stroke. It appears to accomplish this via its finbrinolytic, anti-inflammatory and
modulating effect on blood pressure. Studies on hypertension demonstrate an average drop of 10.9% in Systolic Blood
Pressure and a 9.7 percent drop in Diastolic Blood Pressure.2,3,4
A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to
demonstrate fibrinolytic activity. The volunteers were given 200 grams of natto (the food) before breakfast, then their
fibrinolytic activity was tested over time. The results indicate natto generates an increased ability to dissolve blood
clots. As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their
fibrinolytic activity. The tests showed no significant change.5
The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a
cardiovascular event. For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted. The
physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo
has been further identified.6,7

Nattokinase and Blood Clots

Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system. These clots can
cause blockage of blood flow. If blood flow is blocked, the oxygen supply to that tissue is cut off and it
eventually dies. In the heart, this can result in myocardial infarction (heart attack). In the brain, it can result
in strokes or mini-strokes. Deep vein thrombosis can result in pulmonary emboli. All these events can be
life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but
also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood
viscosity. The net results are vascular conditions that are less likely to produce blood clots. The authors
suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8
The process of forming a clot is complex and involves several enzymes. However, the body mainly produces
one central enzyme for dissolving a clot, plasmin. It happens that the properties of nattokinase are very
similar to plasmin. Nattokinase is particularly effective because it enhances the body's natural ability to fight
blood clots in several different ways. It dissolves fibrin directly and appears to enhance the body's natural

production of both plasmin and other clot-dissolving enzymes like urokinase. An in vivo study was
undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in
the common carotid artery of laboratory rats. The results indicate that the thrombolytic activity of nattokinase
is stronger than that of plasmin or elastase in vivo in this model.9
A fascinating study was conducted to measure the effect of nattokinase in the
prevention of deep vein thrombosis and superficial vein thrombosis on extended flights
of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses. The
placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6%
of 94 individuals. After the flight, the degree of edema was increased by 12% in the
placebo group and decreased by 15% in the nattokinase group. The authors
concluded that nattokinase was effective in reducing thrombotic events and in
controlling edema in high-risk subjects on long flights.10

Serracor-NK contains the following ingredients:

SEBkinase is a systemic enzyme blend of two enteric coated, fibrinolytic proteases: Peptizyme SP (Serrapeptase) & NattoSEB

(our Nattokinase contains NO Vitamin K).

NATTOKINASE (NattoSEB) is derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries
for its positive medicinal properties, particularly for cardiovascular disorders. To make natt, soybeans are fermented with the beneficial
bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important
of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties,
including fibrinolytic activity. A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular
blood clots. He called this enzyme "nattokinase"-meaning "enzyme in natto."
SERRAPEPTASE (Peptizyme SP) is an enzyme derived from a species of bacteria originally found in the intestine of silkworms. The
bacteria,Serratia mercesans produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is
now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase's formidable antiinflammatory, proteolytic (protein dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and
proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over
four decades for its anti-inflammatory activity.
BROMELAIN is a collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus), and is known for
its digestive as well its anti-inflammatory properties. Because of its activity across a wide pH range, bromelain is a good substitute for pepsin and
trypsin for both digestive and systemic support.*
PAPAIN is a widely used enzyme obtained from the latex of the fruit of the Papaya tree (Carica papaya). Papain has been used for centuries as an
effective digestive aid.
LIPASE catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells.*
PROTEASES are enzymes that hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller
chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body.
RUTIN is a bioflavonoid that strengthens and tones arteries and veins and provides antioxidant support against free-radicals and inflammation.*
AMLA, or Indian gooseberry (Emblica officinalis), is a natural and efficacious antioxidant. It is one of the richest sources of absorbable vitamin C
available.
COENZYME Q10 is an essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys, and heart. It is a vital
part of energy production and overall cell health.*
MAGNESIUM is an essential mineral used as a cofactor by over 350 enzymes in the body. Magnesium is critical part of cardiovascular and nerve
physiology. It helps relax arteries and assists in proper nerve impulse function.*
References
1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of Nattokinases
Acta Haematol 1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime Hiratanic
aDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;
bDepartment of Biochemistry, Oklahoma State University, Okla., USA;
cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan
2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences Institute, March 2002.
3. Effect of Natto Diet on Blood Pressure. JTTAS, 1995. Maruyama M, Sumi H..
4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583-1588
(2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5,

5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented
Food inJapan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K.,
Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan
6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo.
Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132
7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006
Tai MW , Sweet BV
8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(12):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ
9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10
(1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3
10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled
Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al.