LIST OF PUBLICATIONS

(110 in PubMed search keyword Kempuraj and Duraisamy K)

1.
2.

3.

4.
5.

6.

7.
8.
9.

10.
11.
12.
13.

14.

15.

16.

17.

18.

Kempuraj D, Thangavel R, Natteru PA, Selvakumar GP, Saeed D, Zahoor H, Zaheer S, Iyer SS and
Zaheer A. Neuroinflammation induces neurodegeneration. J Neurol Neurosurg and Spine 1:2016
Conti P, Ronconi G, Caraffa A, Lessiani G, Duraisamy K, IL-37 a new IL-1 family member emerges
as a key suppressor of asthma mediated by mast cells. Immunol Invest Dec 16: 1-12, 2016 [Epub ahead
of print].
Kempuraj D, Thangavel R, Fattal R, Pattani S, Yang E, Zaheer S, Santillan DA, Santillan MK, Zaheer
A. Mast cells release chemokine CCL2 in response to Parkinsonian toxin 1-methyl-4-phenyl-pyridinium
(MPP+). Neurochem Res 41(5):1042-1049, 2016.
Conti P, Kempuraj D. Important role of mast cells in multiple sclerosis. Multi Scler Relat Disord 5:7780, 2016.
Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan DA, Santillan MK, Zaheer A.
Dopaminergic toxin 1-methyl-4-phenylpyridinium, proteins alpha synuclein and glia maturation factor
activate mast cells and release inflammatory mediators. PLoS One 10:e135776, 2015.
Khan MM, Zaheer S, Thangavel R, Patel M, Kempuraj D, Zaheer A. Absence of Glia maturation factor
protects dopaminergic neurons and improves motor behavior in mouse model of Parkinsonism.
Neurochem Res 40(5):980-990, 2015.
Xiong Z, Thangavel R, Kempuraj D, Zaheer A. Alzheimers disease: Evidence for the expression of
inflammatory interleukin-33 and its receptor ST2 in brain. J Alzheimers Dis 40(2):297-308, 2014.
Khan MM, Kempuraj D, Zaheer S, Zaheer A. Glia maturation factor deficiency suppresses 1-Methyl4-Phenylpyridinium-induced oxidative stress in astrocytes. J Mol Neurosci 53(4):590-599, 2014.
Kempuraj D, Khan MM, Thangavel R, Xiong Z, Yang E, Zaheer A. Glia Maturation Factor Induces
Interleukin-33 Release from Astrocytes: Implications for Neurodegenerative Diseases. J Neuroimmune
Pharmacol. 8:643-650, 2013.
Thangavel R, Kempuraj D, Stolmeier D, Anantharam P, Khan MM, Zaheer A. Glia maturation factor
expression in entorhinal cortex of Alzheimers disease brain. Neurochem Res. 38:1777-1784, 2013.
Stolmeier D, Thangavel R, Anantharam P, Khan MM, Kempuraj D, Zaheer A. Glia maturation factor
expression in hippocampus of human Alzheimers disease. Neurochem Res. 38:1580-1589, 2013.
Khan MM, Kempuraj D, Thangavel R, Zaheer A. Protection of MPTP-induced neuroinflammation and
neurodegeneration by Pycnogenol. Neurochem Int. 62:379-388, 2013.
Zaheer S, Thangavel R, Wu Y, Khan MM, Kempuraj D, Zaheer A. Enhanced expression of glia
maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease
mice. Neurochem Res. 38(1):218-25, 2013.
Yuan Z, Meyerholz D, Twait E, Kempuraj D, Williard D, Samuel I. Systemic inflammation with
multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis. J Gastrointest
Surg 15(10):1670-1678, 2011.
Clemons A, Vasiadi M, Kempuraj D, Kourelis T, Vandoros G, Theoharides TC. Amitriptyline and
Prochlorperazine Inhibit Proinflammatory Mediator Release from Human Mast Cells: Possible
Relevance to Chronic Fatigue Syndrome. J Clin Psychopharmacol. 31:385-387, 2011.
Asadi S, Zhang B, Weng Z, Angelidou A, Kempuraj D, Alysandratos KD, Theoharides TC. Luteolin
and thiosalicylate inhibit HgCl2 and thimerosal-induced VEGF release from human mast cells. Int J
Immunopathol Pharmacol. 23(4):1015-20, 2010.
Castellani ML, Shaik-Dasthagirisaheb YB, Tripodi D, Anogeianaki A, Felaco P, Toniato E, De Lutiis
MA, Fulcheri M, Tet S, Galzio R, Salini V, Caraffa A, Antinolfi P, Frydas I, Sabatino G, Kempuraj
D. Interrelationship between vitamins and cytokines in immunity. J Biol Regul Homeost Agents
24(4):385-90, 2010.
Kempuraj D, Conti P, Vasiadi M, Alysandratos KD, Tagen M, Kalogeromitros D, Kourelis T,
Gregoriou S, Makris M, Stavrianeas NG, Theoharides TC. IL-32 is increased along with tryptase in

19.

20.

21.

22.

23.
24.

25.

26.

27.

28.
29.
30.

31.

32.

33.

lesional psoriatic skin and is up-regulated by substance P in human mast cells. Eur J Dermatol.
20(6):865-7, 2010.
Samuel I, Yuan Z, Meyerholz DK, Twait E, Williard DE, Kempuraj D. A novel model of severe
gallstone pancreatitis: murine pancreatic duct ligation results in systemic inflammation and substantial
mortality. Pancreatology 10(5):536-44, 2010.
Rozniecki JJ, Sahagian GG, Kempuraj D, Tao K, Jocobson S, Zhang B, Theoharides TC. Brain
metastases of mouse mammary adenocarcinoma is increased by acute stress. Brain Res. 1366:204-10,
2010.
Castellani ML, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Shaik B, Fulcheri M, Vecchiet J,
Tet S, Salini V, Theoharides TC, Caraffa A, Antinolfi P, Frydas I, Conti P, Cuccurullo C, Ciampoli C,
Cerulli G, Kempuraj D. IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells.
J Biol Regul Homeost Agents 24(2):131-5, 2010.
Castellani ML, De Lutiis MA, Toniato E, Conti F, Felaco P, Fulcheri M, Theoharides TC, Caraffa A,
Antinolfi P, Conti P, Cuccurullo C, Ciampoli C, Felaco M, Orso C, Salini V, Cerulli G, Kempuraj D,
Tet S, Shaik B. Impact of RANTES, MCP-1 and IL-8 in mast cells. J Biol Regul Homeost Agents
24(1):1-6, 2010.
Kempuraj D, Asadi S, Zhang B, Manola A, Hogan J, Peterson E, Theoharides TC. Mercury induces
inflammatory mediator release from human mast cells. J Neuroinflammation 7:20, 2010.
Boucher W, Kempuraj D, Michaelian M, Theoharides TC. Corticotropin-releasing hormone-receptor
2 is required for acute stress-induced bladder vascular permeability and release of vascular endothelial
growth factor. BJU Int. 106(9):1394-9, 2010.
Theoharides TC, Zhang B, Kempuraj D, Tagen M, Vasiadi M, Angelidou A, Alysandratos KD,
Kalogeromitros D, Asadi S, Stavrianeas N, Peterson E, Leeman S, Conti P. IL-33 augments substance
P-induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci
U S A 107(9):4448-53, 2010.
Tagen M, Elorza A, Kempuraj D, Boucher W, Kepley CL, Shirihai OS, Theoharides TC. Mitochondrial
uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J
Immunol.183(10):6313-9, 2009.
Felaco P, Castellani ML, De Lutiis MA, Felaco M, Pandolfi F, Salini V, De Amicis D, Vecchiet J, Tete
S, Ciampoli C, Conti F, Cerulli G, Caraffa A, Antinolfi P, Cuccurullo C, Perrella A, Theoharides TC,
Conti P, Toniato E, Kempuraj D, Shaik YB. IL-32: a newly-discovered proinflammatory cytokine. J
Biol Regul Homeost Agents 23(3):141-7, 2009.
Vasiadi M, Kalogeromitros D, Kempuraj D, Clemons A, Theoharides TC. Rupatadine Inhibits
Secretion from HMC-1 and LAD2 Human Mast Cells Int Arch Allergy Immunol. 151(1):38-45, 2009.
Theoharides TC, Kempuraj D, Redwood L. Autism - an emerging neuroimmune disorder in search
of therapy. Expert Opin on Pharmacother 10(13):2127-43, 2009.
Castellani ML, Kempuraj D, Salini V, Vecchiet J, Tete S, Ciampoli C, Conti F, Cerulli G, Caraffa A,
Antinolfi P, Theoharides TC, De Amicis D, Perrella A, Cuccurullo C, Boscolo P, Shaik Y. The latest
interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator. J Biol Regul Homeost
Agents 23(1):11-4, 2009.
Castellani ML, Conti CM, Kempuraj D, Salini V, Vecchiet J, Tete S, Ciampoli C, Conti F, Cerulli G,
Caraffa A, Antinolfi P, Galzio R, Shaik Y, Theoharides TC, De Amicis D, Perrella A, Cuccurullo C,
Boscolo P, Felaco M, Doyle R, Verrocchio C, Fulcheri M. Autism and immunity: revisited study. Int J
Immunopathol Pharmacol. 22(1):15-9, 2009.
Huang M, Kempuraj D, Papadopoulou N, Kourelis T, Donelan J, Manola A, Theoharides T. Urocortin
induces IL-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-{kappa}B
activation. J Mol Endocrinol. 42:397-405, 2009.
Theoharides TC, Kempuraj D, Marchand J, Tzianoumis L, Vasiadi M, Katsarou-Katsari A, Makris M,
Kalogeromitros D. Urticaria pigmentosa associated with acute stress and lesional skin mast-cell
expression of CRF-R1. Clin Exp Dermatol. 34(5): e163-6, 2008.

34.
35.

36.
37.

38.

39.

40.

41.

42.
43.
44.

45.

46.
47.

48.

49.
50.
51.

Theoharides TC, Kempuraj D, Kourelis T, Manola A. Human mast cells stimulate activated T cells:
Implications for multiple sclerosis. Ann N Y Acad Sci. 1144:74-82, 2008.
Theoharides TC, Kempuraj D, Vakali S, Sant GR. Treatment refractory interstitial cystitis/painful
bladder syndrome with cystoprotek an oral multi-agent natural supplement. Can J Urol. 15(6):44104414, 2008.
Theoharides TC, Rozniecki JJ, Sahagian G, Jocobson S, Kempuraj D, Conti P, Kalogeromitros D.
Impact of stress and mast cell on brain metastases. J Neuroimmunol. 205(1-2):1-7, 2008.
Kalogeromitros D, Makris M, Chliva C, Aggelides X, Kempuraj D, Theoharides TC. A quercetin
containing supplement reduces niacin-induced flush in humans. Int J Immunopathol Pharmacol.
21(3):509-14, 2008.
Kempuraj D, Tagen M, Iliopoulou B, Clemons A, Vasiadi M, Boucher W, House M, Wolfberg A,
Theoharides TC. Luteolin inhibits myelin basic protein-induced human mast cells activation and mast
cell-dependent stimulation of T cells. Br J Pharmacol.155:1076-84, 2008.
Papaliodis D, Boucher W, Kempuraj D, Michaelian M, Wolfberg A, House M, Theroharides TC.
Niacin-induced flush involves release of prostaglandin D2 from mast cells and serotonin from
platelets: evidence from human cells in vitro and an animal model. J Pharmacol Exp Ther. 327 (3): 665672, 2008.
Katsanos GS, Anogianaki A, Castellani ML, Ciampoli C, De Amicis D, Orso C, Pollice R, Vecchiet J,
Tete S, Salini V, Caraffa A, Patruno A, Shail YB, Kempuraj D, Doyle R, Antinolfi PL, Cerulli G, Conti
CM, Fulcheri M, Neri G, Sabatino G. Biology of neurotensin: revisited study. Int J Immunopathol
Pharmacol. 21:255-259, 2008.
Boucher W, Stern JM, Kotsinyan V, Kempuraj D, Papaliodis D, Cohen MS, Theroharides TC.
Intravesical nanocrystalline silver decreases experimental bladder inflammation. J Urol. 179(4):1598602, 2008.
Papaliodis D, Boucher W, Kempuraj D, Theoharides TC. The flavonoid luteolin inhibits niacin-induced
flush. Br J Pharmacol. 153:1382-1387, 2008.
Karapanou V, Kempuraj D, Theoharides TC. Interleukin-8 is increased in gingival crevicular fluid from
patients with acute pulpitis. J Endod. 34(2):148-51, 2008.
Castellani ML, Ciampoli C, Felaco M, Tet S, Conti CM, Salini V, De Amicis D, Orso C, Antinolfi PL,
Caraffa A, Cerulli G, Boscolo P, Theoharides TC, Conti P, Kempuraj D. Neuropeptide substance P
induces mRNA expression and secretion of CXCL8 chemokine, and HDC in human umbilical cord
blood mast cells. Clin Invest Med. 31(6): E362-372, 2008.
Conti P, Castellani ML, Kempuraj D, Salini V, Vecchiet J, Tet S, Mastrangelo F, Perrella A, De Lutiis
MA, Tagen M, Theoharides TC. Role of mast cells in tumor growth. Ann Clin Lab Sci. 37(4):315-22,
2007.
Sugimoto K, Theoharides TC, Kempuraj D, Conti P. Response of spinal myoclonus to a combination
therapy of autogenic training and biofeedback. Biopsychosoc Med. 1:18, 2007.
Castellani ML, Bhattacharya K, Tagen M, Kempuraj D, Perrella A, De Lutiis M, Boucher W, Conti P,
Theoharides TC, Cerulli G, Salini V, Neri G. Anti-chemokine therapy for inflammatory diseases. Int J
Immunopathol Pharmacol. 20(3):447-53, 2007.
Theoharides TC, Kempuraj D, Iliopoulou BP. Mast cells, T cells, and inhibition by luteolin:
implications for the pathogenesis and treatment of multiple sclerosis. Adv Exp Med Biol. 601:423-30,
2007.
Theoharides TC, Kempuraj D, Tagen M, Conti P, Kalogeromitros D. Differential release of mast cell
mediators and the pathogenesis of inflammation. Immunol Rev. 217:65-78, 2007.
Sant GR, Kempuraj D, Marchand JE, Theoharides TC. The mast cell in interstitial cystitis: role in
pathophysiology and pathogenesis. Urology 69(4 Suppl):34-40, 2007.
Kalogeromitros D, Syrigou EK, Makris M, Kempuraj D, Stavrianeas NG, Vasiadi M, Theoharides TC.
Nasal provocation of patients with allergic rhinitis and the ypothalamic-pituitary-adrenal axis. Ann
Allergy Asthma Immunol. 98(3):269-73, 2007.

52.

53.

54.
55.

56.
57.

58.

59.

60.
61.

62.

63.

64.

65.

66.

67.

68.

Bhattacharya K, Farwell K, Huang M, Kempuraj D, Donelan J, Papaliodis D, Vasiadi M, Theoharides

TC. Mast cell deficient W/Wv mice have lower serum IL-6 and less cardiac tissue necrosis than their
normal littermates following myocardial ischemia- eperfusion. Int J Immunopathol Pharmacol.
20(1):69-74, 2007.
Tagen M, Stiles L, Kalogeromitros D, Gregoriou S, Kempuraj D, Makris M, Donelan J, Vasiadi M,
Staurianeas NG, Theoharides TC. Skin Corticotropin-Releasing Hormone Receptor Expression in
Psoriasis. J Invest Dermatol. 127 (7):1789-91, 2007.
Boucher W, Kempuraj D, Cao J, Papaliodis D, Theoharides TC. Intravesical suplatast tosilate (IPD1151T) inhibits experimental bladder inflammation. J Urol. 177(3):1186-90, 2007.
Castellani ML, Perrella A, Kempuraj D, Boucher W, Tagen M, Salini V, Vecchiet J, Tete S, Frydas S,
Theoharides TC, Conti P. Immunological activation of human umbilical cord blood mast cells induces
tryptase secretion and interleukin-6, and histidine decarboxilase mRNA gene expression. Pharmacol
Res. 55(1):57-63, 2007.
Kalogeromitros D, Gregoriou S, Makris M, Georgala S, Kempuraj D, Theoharides TC. Secondary
anetoderma associated with mastocytosis. Int Arch Allergy Immunol. 142(1):86-8, 2007.
Theoharides TC, Kempuraj D, Tagen M, Vasiadi M, Cetrulo CL. Human umbilical cord blood-derived
mast cells: a unique model for the study of neuro-immuno-endocrine interactions. Stem Cell Rev.
2(2):143-54 2006.
Kempuraj D, Castellani ML, Petrarca C, Frydas S, Conti P, Theoharides TC, Vecchiet J. Inhibitory
effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA
transcription by human mast cell-1 cell line. Clin Exp Med. 6(4):150-6, 2006.
Castellani ML, Kempuraj D, Frydas S, Theoharides TC, Simeonidou I, Conti P, Vecchiet J. Inhibitory
effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA
transcription by human mast cell-1 cell line. Neuroimmunomodulation 13(3):179-86, 2006.
Vasiadi M, Kempuraj D, Boucher W, Kalogeromitros D, Theoharides TC. Progesterone inhibits mast
cell secretion. Int J Immunopathol Pharmacol. 19(4):787-94, 2006.
Cao J, Boucher W, Kempuraj D, Donelan JM, Theoharides TC. Acute stress and intravesical
corticotropin-releasing hormone induces mast cell dependent vascular endothelial growth factor release
from mouse bladder explants. J Urol.176(3):1208-13, 2006.
Kandere-Grzybowska K, Kempuraj D, Cao J, Cetrulo CL, Theoharides TC. Regulation of IL-1induced selective IL-6 release from human mast cells and inhibition by quercetin. Br J Pharmacol.
148(2):208-15, 2006.
Kalogeromitros D, Kempuraj D, Katsarou-Katsari A, Makris M, Gregoriou S, Papaliodis D,
Theoharides TC. Theophylline as 'add-on' therapy to cetirizine in patients with chronic idiopathic
urticaria. A randomized, double-blind, placebo-controlled pilot study. Int Arch Allergy Immunol.
139(3):258-64, 2006.
Donelan J, Marchand JE, Kempuraj D, Papadopoulou N, Papaliodis D, Theoharides TC. Perifollicular
and perivascular mouse skin mast cells express corticotropin-releasing hormone receptor. J Invest
Dermatol.126(4):929-32, 2006.
Kempuraj D, Petrarca C, Frydas S, Riccioni G, Conti P, Tete S, Vecchiet J. Rat peritoneal mast cells
release regulated upon activation normal T cell expressed and secreted (RANTES) after TNF-alpha
activation. J Biol Regul Homeost Agents 19(3-4):130-5, 2005.
Trakatelli C, Frydas S, Hatzistilianou M, Papadopoulos E, Simeonidou I, Founta A, Paludi D, Petrarca
C, Castellani ML, Papaioannou N, Salini V, Conti P, Kempuraj D, Vecchiet J. Chemokines as markers
for parasite-induced inflammation and tumors. Int J Biol Markers 20(4):197-203, 2005.
Papadopoulou NG, Oleson L, Kempuraj D, Donelan J, Cetrulo CL, Theoharides TC. Regulation of
corticotropin-releasing hormone receptor-2 expression in human cord blood-derived cultured mast cells.
J Mol Endocrinol. 35(3): R1-8, 2005.
Theoharides TC, Papaliodis D, Tagen M, Konstantinidou A, Kempuraj D, Clemons A. Chronic fatigue
syndrome, mast cells, and tricyclic antidepressants. J Clin Psychopharmacol. 25(6):515-20, 2005.

69.

70.

71.

72.

73.

74.

75.

76.
77.

78.

79.

80.

81.

82.

83.

84.

Kalogeromitros D, Kempuraj D, Katsarou-Katsari A, Gregoriou S, Makris M, Boucher W, Theoharides

TC. Theophylline as "add-on" therapy in patients with delayed pressure urticaria: a prospective selfcontrolled study. Int J Immunopathol Pharmacol. 18(3):595-602, 2005.
Ramakrishnan R, Kempuraj D, Prabhakaran K, Jayakumar AR, Devi RS, Suthanthirarajan N,
Namasivayam A. A short-term diabetes induced changes of catecholamines and p38-MAPK in discrete
areas of rat brain. Life Sci. 77(15):1825-35, 2005.
Cao J, Papadopoulou N, Kempuraj D, Boucher WS, Sugimoto K, Cetrulo CL, Theoharides TC. Human
mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective
secretion of vascular endothelial growth factor. J Immunol. 174(12):7665-75, 2005.
Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo CL,
Theoharides TC. Flavonols inhibit proinflammatory mediator release, ntracellular calcium ion levels
and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol. 145(7):934-44, 2005.
Petrarca C, Frydas S, Donelan J, Boucher W, Papadopoulou N, Cao J, Castellani ML, Conti P, Toniato
E, Robuffo I, Vecchiet J, Iezzi T, Madhappan B, Kempuraj D. Interleukin 27 (IL-27): A novel
pleiotropic cytokine involved in T cell differentiation and T cell response modulation. Int J
Immunopathol Pharmacol. 18(2):191-4, 2005.
Di Giannantonio M, Frydas S, Kempuraj D, Karagouni E, Hatzistilianou M, Conti CM, Boucher W,
Papadopoulou N, Donelan J, Cao J, Madhappan B, Boscolo P, Petrarca C, Castellani L, Quartesan L,
Doyle R, Ferro FM. Cytokines in stress. Int J Immunopathol Pharmacol. 18(1):1-5, 2005.
Kempuraj D, Papadopoulou N, Stanford EJ, Christodoulou S, Madhappan B, Sant GR, Solage K,
Adams T, Theoharides TC. Increased numbers of activated mast cells in endometriosis lesions positive
for corticotropin-releasing hormone and urocortin. Am J Reprod Immunol. 52(4):267-75, 2004.
Theoharides TC, Donelan JM, Papadopoulou N, Cao J, Kempuraj D, Conti P. Mast cells as targets of
corticotropin-releasing factor and related peptides. Trends Pharmacol Sci. 25(11):563-8, 2004.
Frydas S, Karagouni E, Hatzistilianou M, Kempuraj D, Comani S, Petrarca C, Iezzi T, Verna N, Conti
P, Castellani ML. Cytokines and allergic disorders: revisited study. Int J Immunopathol Pharmacol.
17(3):233-5, 2004.
Kempuraj D, Konstantinidou A, Boscolo P, Ferro F, Di Giannantonio M, Conti CM, Merlitti D,
Petrarca C, Castellani ML, Doyle R, Theoharides TC. Cytokines and the brain. Int J Immunopathol
Pharmacol. 17(3):229-32, 2004.
Kempuraj D, Donelan J, Frydas S, Iezzi T, Conti F, Boucher W, Papadopoulou NG, Madhappan B,
Letourneau L, Cao J, Sabatino G, Meneghini F, Stellin L, Verna N, Riccioni G, Theoharides TC.
Interleukin-28 and 29 (IL-28 and IL-29): new cytokines with anti-viral activities. Int J Immunopathol
Pharmacol. 17(2):103-6, 2004.
Huang SH, Frydas S, Kempuraj D, Barbacane RC, Grilli A, Boucher W, Letourneau R, Madhappan B,
Papadopoulou N, Verna N, De Lutiis MA, Iezzi T, Riccioni G, Theoharides TC, Conti P. Interleukin17 and the interleukin-17 family member network. Allergy Asthma Proc. 25(1):17-21, 2004.
Kempuraj D, Devi RS, Madhappan B, Conti P, Nazer MY, Christodoulou S, Reginald J,
Suthinthirarajan N, Namasivayam A. T lymphocyte subsets and immunoglobulins in intracranial tumor
patients before and after treatment, and based on histological type of tumors. Int J Immunopathol
Pharmacol. 17(1):57-64, 2004.
Huang SH, Frydas S, Conti P, Kempuraj D, Barbacane RC, Grilli A, Boucher W, Letourneau R,
Papadopoulou N, Donelan J, Madhappan B, Theoharides TC, De Lutiis MA, Riccioni G, Sabatino G.
Interleukin-17: a revisited study. Int J Immunopathol Pharmacol. 17(1):1-4, 2004.
Kempuraj D, Papadopoulou NG, Lytinas M, Huang M, Kandere-Grzybowska K,
Madhappan B, Boucher W, Christodoulou S, Athanassiou A, Theoharides TC. Corticotropin-releasing
hormone and its structurally related urocortin are synthesized and secreted by human mast cells.
Endocrinology 145(1):43-8, 2004.
Alexandrakis M, Letourneau R, Kempuraj D, Kandere-Grzybowska K, Huang M, Christodoulou S,
Boucher W, Seretakis D, Theoharides TC. Flavones inhibit proliferation and increase mediator content
in human leukemic mast cells (HMC-1). Eur J Haematol. 71(6):448-54, 2003.

85.

Kempuraj D, Huang M, Kandere-Grzybowska K, Basu S, Boucher W, Letourneau R,

Athanassiou A, Theoharides TC. Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as
NF-kappaB activation and intracellular calcium ion levels in normal human mast cells. Int Arch Allergy
Immunol. 132(3):231-9, 2003.
86. Alexandrakis MG, Kyriakou DS, Kempuraj D, Huang M, Boucher W, Seretakis D,
Theoharides TC. The isoflavone genistein inhibits proliferation and increases histamine content in
human leukemic mast cells. Allergy Asthma Proc. 24(5):373-7, 2003.
87. Frydas S, Hatzistilianou M, Karagouni E, Madhappan B, D'Orazio N, Riccioni G, Conti F, Carratelli G,
Kempuraj D. Chemokines and parasites. Int J Immunopathol Pharmacol. 16(3):221-4, 2003.
88. Kempuraj D, Frydas S, Conti P, Kandere- Grzybowska K, Boucher W, Letourneau
R, Madhappan B, Huang SH, Sugimoto K, Papadopoulou NG, Christodoulou S, Theoharides TC.
Interleukin-25 (or IL-17E): a new IL-17 family member with growth factor/inflammatory actions. Int J
Immunopathol Pharmacol. 16(3):185-8, 2003.
89. Kandere-Grzybowska K, Letourneau R, Kempuraj D, Donelan J, Poplawski S, Boucher W,
Athanassiou A, Theoharides TC. IL-1 induces vesicular secretion of IL-6 without degranulation from
human mast cells. J Immunol. 171(9):4830-6, 2003.
90. Conti P, Kempuraj D, Frydas S, Kandere K, Boucher W, Letourneau R, Madhappan B, Sagimoto K,
Christodoulou S, Theoharides TC. IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26.
Immunol Lett. 88(3):171-4, 2003.
91. Kempuraj D, Frydas S, Kandere K, Madhappan B, Letourneau R, Christodoulou S, Boucher W,
Riccioni G, Conti P, Theoharides TC. Interleukin-19 (IL-19) network revisited. Int J Immunopathol
Pharmacol. 16(2):95-7, 2003.
92. Madhappan B, Kempuraj D, Christodoulou S, Tsapikidis S, Boucher W, Karagiannis V, Athanassiou
A, Theoharides TC. High levels of intrauterine corticotropin-releasing hormone, urocortin, tryptase, and
interleukin-8 in spontaneous abortions. Endocrinology 144(6):2285-90, 2003.
93. Lytinas M, Kempuraj D, Huang M, Boucher W, Esposito P, Theoharides TC. Acute stress results in
skin corticotropin-releasing hormone secretion, mast cell activation and vascular permeability, an effect
mimicked by intradermal corticotropin-releasing hormone and inhibited by histamine-1 receptor
antagonists. Int Arch Allergy Immunol. 130(3):224-31, 2003.
94. Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Barbacane RC, Castellani ML, Felaco M, Boucher
W, Letourneau R, Theoharides TC. IL-10, an inflammatory/inhibitory cytokine, but not always.
Immunol Lett. 86(2):123-9, 2003.
95. Bielory L, Kempuraj D, Theoharides T. Topical immunopharmacology of ocular allergies. Curr Opin
Allergy Clin Immunol. 2(5):435-45, 2002.
96. Alexandrakis MG, Kyriakou DS, Seretakis D, Boucher W, Letourneau R, Kempuraj D, Theoharides
TC. Inhibitory effect of retinoic acid on proliferation, maturation and tryptase level in human leukemic
mast cells (HMC-1). Int J Immunopathol Pharmacol. 16(1):43-7, 2003.
97. Frydas S, Madhappan B, Kempuraj D. Some aspects of Parasitology and Immunology in general
Medicine. Int J Immunopathol Pharmacol. 15(3):165-170, 2002.
98. Conti P, Kempuraj D, Di Gioacchino M, Boucher W, Letourneau R, Kandere K, Barbacane RC, Reale
M, Felaco M, Frydas S, Theoharides TC. Interleukin-6 and mast cells. Allergy Asthma Proc. 23(5):3315, 2002.
99. Kempuraj D, Huang M, Kandere K, Boucher W, Letourneau R, Jeudy S, Fitzgerald K, Spear K,
Athanasiou A, Theoharides TC. Azelastine is more potent than olopatadine n inhibiting interleukin-6
and tryptase release from human umbilical cord blood-derived cultured mast cells. Ann Allergy Asthma
Immunol. 88(5):501-6, 2002.
100. Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Reale M, Barbacane RC, Castellani ML, Mortari
U, Boucher W, Letourneau R, Theoharides TC. Interleukin-16 network in inflammation and allergy.
Allergy Asthma Proc. 23(2):103-8, 2002.

101. Pehlivanidis C, Fotoulaki M, Boucher W, Kempuraj D, Pang X, Konstantinidou A, Theoharides TC.

Acute stress-induced seizures and loss of consciousness in a ten-year-old boy with cutaneous astocytosis.
J Clin Psychopharmacol. 22(2):221-4, 2002.
102. Lytinas M, Kempuraj D, Huang M, Kandere K, Boucher W, Letourneau R, Jeudy S, Fitzgerald K,
Spear K, Athanasiou A, Theoharides TC. Azelastine's inhibition of histamine and tryptase release from
human umbilical cord blood-derived cultured mast cells as well as rat skin mast cell-induced vascular
permeability: comparison with olopatadine. Allergy Asthma Proc. 23(1):45-51, 2002.
103. Boucher WS, Letourneau R, Huang M, Kempuraj D, Green M, Sant GR, Theoharides TC. Intravesical
sodium hyaluronate inhibits the rat urinary mast cell mediator increase triggered by acute immobilization
stress. J Urol. 167(1):380-4, 2002.
104. Theoharides TC, Alexandrakis M, Kempuraj D, Lytinas M. Anti-inflammatory actions of flavonoids
and structural requirements for new design. Int J Immunopathol Pharmacol. 14(3):119-127, 2001.
105. Conti P, Kempuraj D, Boucher W, Letourneau R, Theoharides TC. Mechanism by which IL-16
generated by mast cells mediates allergic inflammation. Int J Immunopathol Pharmacol. 14(1):1-4, 2001.
106. Theoharides TC, Kempuraj D, Sant GR. Massive extracellular tryptase from activated bladder mast
cells in interstitial cystitis. Urology 58(4):605-6, 2001.
107. Theoharides TC, Kempuraj D, Sant GR. Mast cell involvement in interstitial cystitis: a review of
human and experimental evidence. Urology 57(6 Suppl 1):47-55, 2001.
108. heoharides TC, Patra P, Boucher W, Letourneau R, Kempuraj D, Chiang G, Jeudy S, Hesse L,
Athanasiou A. Chondroitin sulphate inhibits connective tissue mast cells. Br J Pharmacol. 131(6):103949, 2000.
109. Ahn K, Takai S, Pawankar R, Kuramasu A, Ohtsu H, Kempuraj D, Tomita H, Iida M, Matsumoto K,
Akasawa A, Miyazaki M, Saito H. Regulation of chymase production in human mast cell progenitors.
J Allergy Clin Immunol. 106(2):321-8, 2000.
110. Kempuraj D, Saito H, Kaneko A, Fukagawa K, Nakayama M, Toru H, Tomikawa M, Tachimoto H,
Ebisawa M, Akasawa A, Miyagi T, Kimura H, Nakajima T, Tsuji K, Nakahata T. Characterization of
mast cell-committed progenitors present in human umbilical cord blood. Blood 93(10):3338-46, 1999.
111. Kanbe N, Kurosawa M, Miyachi Y, Kanbe M, Kempuraj D, Tachimoto H, Saito H. Carnoy's fixative
reduces the number of chymase-positive cells in immunocytochemical staining of cord-blood-derived
human cultured mast cells. Allergy 53(10):981-5, 1998.