5/11/2011

Nanotechnology

Nano Technology in Cosmetics

What is nanotechnology
Nanotechnology manipulates materials at an incredibly
small scale.

Esti Hendradi
Department of Pharmaceutics
Faculty of Pharmacy Airlangga University

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Nanotechnology
Surface Area

Rute of penetration of drug

Easy penetration through

skin
Effectivity

Nanoparticle 1m

Particle 1m

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Nano Technology in Cosmetics

Where is the application in many cosmetic products?

The applications of nanotechnology and nanomaterials can

be found in many cosmetic products including
moisturisers, hair care products, make up and sunscreen.

Schematic representation of stratum corneum and its

intercellular and transcellular pathways of drug permeation.

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

5/11/2011

The main uses for nanotechnology in cosmetics

nanoparticles

Nanoparticles as UV
filters
Titanium dioxide
(TiO2) and zinc oxide
(ZnO)

nanotechnology for
delivery

Nanotechnology for delivery cosmetics

Liposome

Niosome

-Small unilamellar vesicles

(SUVs): 100nm
-Multilamellar vesicles
(MLVs): 100 nm- 3 m
- Large unilamellar vesicles
(LUVs)

-Small unilamellar vesicles

(SUVs): 100nm
-Multilamellar vesicles
(MLVs): 100 nm- 3 m
- Large unilamellar vesicles
(LUVs)

Transfersome

Liposome
Niosome
Transfersom
Nano Emulsion
Solid Lipid Nanoparticle
Nanostructured lipid
carriers
Dendrimer
Nanocrystal
Nanoencapsulation

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

-Each transfersome consists of

at least one inner aqueous
compartment.
- Size 200-300 nm

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Nanotechnology for delivery cosmetics

Nanotechnology for delivery cosmetics
The advantages of liposome
-Biocompatibility
-Biodegradablelity
-Relatively low toxicity

Liposome
Liposomes are vesicular
structures with an aqueous
core surrounded by a
hydrophobic lipid bilayer,
created by the extrusion of
phospholipids.
The advantages
- ease of preparation
-to improve the absorption of
active ingredients by skin
-ease of scale up
Preparation:
-Skin care product
- Shampo (for treatment hair
loss)
-Vitamin2 (A and E)
-Softening and conditioning

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Niosome
Niosomes are non-ionic
surfactant based vesicles that
have a similar structure to that
of phospholipid vesicles like
liposome
The advantages
They can be used to
encapsulate aqueous solutes
and act as drug and cosmetic
carrier
Preparation:
-Skin care products

Transfersome
Trasfersome are vesicles which
are more elastic than liposomes
and have improved efficiency.
The advantages
These self assembled lipid droplets
with elastic bilayers are capable of
spontaneous penetration of the
stratum corneum through
intracellular or transcellular routes
and have potential applications in
cosmetics and drug delivery

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

5/11/2011

Nanotechnology for delivery cosmetics

Nanotechnology for delivery cosmetics

Emulsion
Preparation:
-Hair sunscreen, sun care ect

Microemulsion/Nanoemulsion

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Nanotechnology for delivery cosmetics

Solid Lipid Nano Particle (SLN)

Symposium Healthy and Beauty Skin, Surabaya, May 14-15

th,

2011

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

5/11/2011

Nanotechnology for delivery cosmetics

Nanotechnology for delivery cosmetics

Nanostructure Lipid Carrier (NLC)

Solid Lipid Nano Particle (SLN)

Preparation: - Sunscreen,

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Nano Technology in Cosmetics

Characterisa
tion
techniques

Scanning Electron Microscopy (SEM) to explore shape and

morphology
SEM coupled with Energy Dispersive X-Ray diffraction
(EDAX) allows elemental information to be gained for
individual particles
Surface area measurements and Powder X-ray Diffraction
(XRD) for crystallinity/ morpholoyg and size
Particle size determination (PSD) technology such as Disc
centrifugation
Dynamic Light Scattering and other PSD methods to
measure size of the dispersed liposomes
Cryo-SEM and cryo preparation preserve nano-liposome
microstructure and allows imaging
Wide range of HPLC/UPLC detection systems to quantify the
levels of active present
Sensitive ICP-MS and ICP-OES to determine trace metals
and quantify nanoactives such as nanosilver

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Type of NLC :
-imperfect structure type
-structureless/amorphous
-multiple type
Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Nano Gold in Cosmetics

What is the main properties of Nano Gold in beauty care compositions?
- It vitalizes the fiber tissues under the skin.
accelerates blood circulation.
- Releases the natural active ingredient
transported by the surface of the nano
particles
- Powerful antioxidant against free radicals
- Antiseptic and anti-inflammatory properties
-

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

5/11/2011

Nano Gold
- Reduces fine lines and wrinkles.
- Improves the firmness and elasticity of
the skin.
- Vitalizes skin metabolism.
- Synergists in absorption of collagens,
nutrients and essences of herbal and
botanical extracts.
- Delays aging process and maintain skin
youthful appearan

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

One popular question is that Nanotechnology

used has any potential risk to envelopment or to
human health or not?.

Disadvantages

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011

Thank you !!
Terimakasih !!

Symposium Healthy and Beauty Skin, Surabaya, May 14-15 th, 2011