Documentos de Académico
Documentos de Profesional
Documentos de Cultura
IC2
Tropical Medicine
TM
Immunisation: past and future
Prof. Samuel McConkey
10th September 2015
Objectives
To understand, through examples, the success
of vaccines
The concept of vaccines
History of vaccines
Future of vaccine development e.g. Ebola
100
80
60
40
20
2011
2009
2007
2005
2003
2001
1999
1997
1995
1993
1991
1989
1987
Figure. 1. Number of Meningococcal C events on CIDR by Year & Quarter, Q11999 to Q2-2014
From Health Protection Surveillance Centre, Dublin Sept 2014
$332b
$25.1b
Organo-inorganic compounds
$ 87b
$23.6b
$134b
$ 9.5b
$ 68b
$ 3.6b
Pfizer Ringaskiddy
Organic Synthesis Plant No 4
Neonatal tetanus
Future
Ebola vaccine
Source: kenyon.edu
DNA plasmids
Vectored- Chimpanzee adenovirus
Correlates of protection
Use studies of partial protection
Antibodies correlation with survival
Neutralising Ab, how much? to which antigen?
Passive transfer experiments
Animal model
Mice
Guinea pig
Hamster
Non-human primates
cynomolgus
rhesus
baboons
African green
Subunits
Glycoprotein
Plasmid DNA
Works in Guinea pigs
Adenovirus 5
Has gone to Phase I study
Clinical trials
Phase I- immunogenicity in human, tolerability
Phase II- efficacy, likely no trials in humans
Deployment based on safety and
immunogenicity in humans and
efficacy in animal models
Licensing
Manufacturing and distribution