Supplemental Material: Annu. Rev. Pathol. Mech. Dis.

Supplemental Material: Annu. Rev. Pathol. Mech. Dis. 2009.
4:199-227
doi: 10.1146/annurev.pathol.4.110807.092222
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Lee and Dutta
Supplemental Table 1. MicroRNAs (miRNAs) up- or downregulated in various
tumors relative to normal tissues
miRNA Up/down Cancer Reference

Up Colon cancer 1
Down Breast cancer 2
Down Prostate cancer 3
Down Hepatocellular cancer 4
Down Gastric tumor 5
let-7
Up Uterine leiomyoma 6
Up Pancreatic cancer 7
Up Hepatocelluar carcinoma 8
Down Lung cancer 9
Down Lung cancer 10
miR-9 Up Breast cancer 12
Down Neuroblastoma 13
Up Breast cancer 12
miR-10b
Up Glioblastoma 14
Up Neuroblastoma 15
miR-17-5p
miR-18 Up Hepatocellular carcinoma 17
Up Breast cancer 2
Up Colorectal cancer 18
Up Ovarian cancer 19
Up Hepatocellular cancer 20
Up Cervical cancer 21
Up Chronic lymphocytic leukemia 23
Up Uterine leiomyoma 6
miR-21 Up Pancreatic cancer 7
Down Pituitary adenomas 24
Up Breast tumor 25
Up Pancreatic tumor 26
Up Hepatocelluar carcinoma 8
Up Cholangiocarcinoma 27
Up Lung cancer 28
Up Breast cancer 29
Up Glioblastoma 30
miR-23a Up Pancreatic tumor 26
Supplemental Material: Annu. Rev. Pathol. Mech. Dis. 2009. 4:199-227
MicroRNAs in Cancer
Lee and Dutta
miR-23b Up Uterine leiomyoma 6

miR-23 Up Hepatocelluar carcinoma 8
miR-26a Down Thyroid cancer 31
miR-26b Up Pancreatic tumor 26
miR-27a Up Breast cancer 32
miR-27b Down Breast cancer 33
miR-29s Down Cholangiocarcinoma 34
miR-30a Down Thyroid cancer 31
miR-30d Down Thyroid cancer 31
miR-31 Up Colorectal cancer 35
Down Lung cancer 36
Down Pancreatic cancers 38
miR-34s
Up Renal cell carcinoma 39
Up Colon cancers 40
Up Hepatocellular carcinoma 20
Up Neuroblastoma 15
miR-92
Down Chronic lymphocytic leukemia 23
miR-103 Up Pancreatic tumor 26
miR-122a Down Hepatocellular cancer 4
miR-122 Down Hepatocelluar carcinoma 8
miR-124a Down Colon cancer, lung cancer 41
miR-125a Down Neuroblastoma 13
Up Prostate cancer 42
Down Ovarian cancer 19
miR-125b Down Thyroid cancer 31
miR-126* Down Lung cancer 28
miR-128 Down Glioblastoma 14
miR-130 Up Hepatocelluar carcinoma 8
miR-133b Down Colorectal cancer 35
miR-135b Up Colorectal cancer 35
miR-140 Down Ovarian cancer 19
miR-141
Down Pituitary adenomas 24
miR-143 Down B cell maligancies 43
Down Cervical cancer 21
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Down Colorectal neoplasia 44

miR-144 Down Pituitary adenomas 24
Down B cell maligancies 43
miR-145
Down Colorectal cancer 35
Down Colorectal neoplasia 44
miR-146b Up Papillary thyroid carcinoma 45
miR-149 Up Pituitary adenomas 24
miR-150 Up Chronic lymphocytic leukemia 23
Up Breast cancer 12
Up Chronic lymphocytic leukemia 23
miR-155 Down Pancreatic tumor 26
Up Hodgkin's lymphomas, diffuse large B cell lymphoma, 46
primary mediastinal B cell lymphoma
Up Diffuse large B cell lymphoma 47
Up Burkitt lymphoma 48
miR-181a Up Pancreatic cancer 7
Down Glioblastoma 14
Up Colon cancer 1
miR-181b
Up Papillary thyroid carcinoma 49
Down Glioblastoma 14
miR-181d Up Pancreatic cancer 22
miR-184 Down Neuroblastoma 50
miR-196a Up Pancreatic ductal adenocarcinoma 51
miR-197 Up Thyroid cancer 52
miR-199a
Down Hepatocellular carcinoma 17
miR- Down Hepatocellular carcinoma 17
199a*
miR-200a
Down Hepatocellular carcinoma 17
miR-200c Up Colon cancer 1
miR-205 Up Lung cancer 28
miR-217 Down Pancreatic ductal adenocarcinoma 51
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Up Glioblastoma 53
Up Hepatocellular cancer 4
Up Glioblastoma 14
Up Glioblastoma 53
miR-222 Up Papillary thyroid carcinoma 49
miR-224 Up Hepatocellular carcinoma 17
miR-320 Up Neuroblastoma 15
miR-346 Up Thyroid cancer 52
miR-372 Up Testicular germ cell tumor 54
miR-373 Up Testicular germ cell tumor 54
miR-375 Down Pancreatic cancer 7
miR-376a Up Pancreatic cancer 7
miR-16-1,- Down Chronic lymphocytic leukemia 56
15a cluster Down Pituitary adenomas 57
Down B-cell chronic lymphocytic leukemias 58
Up Erythroleukemia 59
miR-17 Up Lung cancer cell line 60
cluster Up Lung cancer 61
Up B cell lymphomas 62
miR-106a Up T cell leukemia 63
cluster
MicroRNAs in Cancer
Lee and Dutta
Supplemental Table 2. MicroRNAs (miRNAs) that affect the properties of cancer
cells
miRNA +/- Effect on cell growth Note Reference

let-7 + Inhibition of cell growth Lung cancer cell lines 10
+ Inhibition of cell growth G1 arrest A549 lung cancer line or
let-7 hepg2 cell line 64
− Enhanced cell growth A549 lung cancer line
let-7c + Inhibition of cell growth G1 accumulation Hepa-1 65
let-7 + Inhibition of cell growth Lung cancer cell lines 66
+ Inhibition of cell growth
let-7g 67
− Enhanced cell growth
let-7a-3 + Increased anchorage independent growth A549 lung cancer line 68
soft agar assay
let-7 − Enhanced cytotoxicity more apoptosis by Cholangiocarcinoma cell lines 69
gemcitabine, 5-FU, camptothecin
miR-9, - + Inhibition of cell growth decreased brdu
125a, - incorporation Neuroblastoma 13
125b − Enhanced cell growth rescue of RA-induced
growth arrest
+ Increased migration, invasion, intravasation,
miR-10b metastasis 12
− Decreased invasion
miR-16-1,- + Increased apoptosis Megakaryocytic cell line 56
15a MEG-01
+ Inhibition of cell growth adhesion
miR-17-5p independent growth Breast cancer 16
− Enhanced cell growth
miR-17-5p − Inhibition of cell growth increased apoptosis Lung cancer cell line Calu-6 60
and 20a and ACC-LC-172
miR-17- + Enhanced cell growth adhesion independent 70
5p, -20 growth, in vitro culture and engrafted tumor
miR-20a − Increased apoptosis in combination with 71
doxorubicin
miR-17-92 + Enhanced cell growth Chronic myeloid leukemia cell 72
cluster line
miR-17-92 + Increased angiogenesis Colon cancer model 73
cluster
miR-17-92 + Enhanced cell growth Lung cancer cell line 61
cluster
+ Increased invasion, intravasation, metastasis
miR-21 Decreased invasion, intravasation, Colorectal cancer 18
− metastasis
miR-21 − Increased apoptosis reduced tumor growth Glioblastoma 74
upon inhibition by modified LNA in vivo
+ Enhanced cell growth, increased migration Hepatocellular cancer cell
miR-21 Inhibition of cell growth, decreased cell 20
− migration and invasion
lines and normal hepatocytes
miR-21 + Decreased apoptosis upon IL-6 removal Myeloma cell line 75

miR-21 − Inhibition of cell growth in vitro culture and Breast tumor 25
engrafted tumor, increased apoptosis
miR-21 + Decreased cytotoxicity and less apoptosis Cholangiocarcinoma 27
upon gemcitabine treatment in vitro culture
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− Increased cytotoxicity and more apoptosis

upon gemcitabine treatment in vitro culture
miR-21 − Increased apoptosis Glioblastoma cell line 30
miR-26, - + Increased apoptosis
HIF hypoxia-induced mirnas 76
210, -107 − Decreased apoptosis
miR-27a − Increased apoptosis, inhibition of cell Breast cancer cell lines 32
growth
miR-29a, + Inhibition of cell growth in vitro culture and Lung cancer cells 77
b, c engrafted tumor, increased apoptosis
+ Increased apoptosis Cholangiocarcinoma cell line
miR-29b 34
− Decreased apoptosis TRAIL-induced cell death
miR-34a + Inhibition of cell growth in vitro culture and 40

engrafted tumor, senescence-like phenotype
miR-34a + Inhibition of cell growth G1 accumulation 78
miR-34a + Inhibition of cell growth increased apoptosis 38
+ Inhibition of cell growth increased apoptosis
miR-34a Decreased apoptosis induced by genotoxic 79
− stress
miR-34a + G1 accumulation 36
miR-34a + Inhibition of cell growth increased apoptosis Neuroblastoma cell lines 37
miR-34a, - + Inhibition of cell growth G1 accumulation 80
34b, -34c and senescence
miR-34b + Inhibition of cell growth adhesion 81
and -34c independent growth
miR-98 + More resistant to doxorubicin Primary human oral squamous 82
cell carcinoma cell lines
miR-106a + Transformation of NIH3T3 colony 63
cluster formation assay
miR-125a, + Inhibition of cell growth, decreased Breast cancer 83
-125b migration and invasion
+ Enhanced cell growth
miR-125b Prostate cancer cell lines 42
− Inhibition of cell growth
miR-125b − Inhibition of cell growth Differentiated cell lines 84
miR-125b, + Inhibition of cell growth FB-1 cells, thyroid cancer cell 31
-26a line
miR-143, - + Inhibition of cell growth B cell malignancies, Raji cell 43
145
miR-184 + Inhibition of cell growth increased apoptosis Neuroblastoma cell lines 50
miR-197, - − Inhibition of cell growth Thyroid cancer 52
346
miR-221, - − Inhibition of cell growth Glioblastoma 85
222
miR-221, - − Inhibition of cell growth G1 block Glioblastoma 53
222
+ Enhanced cell growth adhesion independent Lncap prostate cancer cell line
miR-221, - growth 86
222 Inhibition of cell growth adhesion
− independent growth PC3 prostate cancer cell line
+ Enhanced cell growth
miR-221 Papillary thyroid carcinoma 49
miR-372, - + Increased cell growth adhesion independent Testicular germ cell tumor 54
373 growth, decreased senescence
Increased cell growth in vitro culture and
+ engrafted tumor, reduced apoptosis,
miR-378 enhanced angiogenesis U87 glioblastoma cell line 87
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EBV-
encoded + Decreased apoptosis Nasopharyngeal carcinoma 88
BART
miRNAs
Phenotypes of cells are described after ectopic expression (denoted as “+” in the second column) or inhibition (“-” in the second
column) of a miRNA.
Abbreviations: EBV, Epstein-Barr virus; TRAIL, tumor necrosis factor--related apoptosis-inducing ligand.
MicroRNAs in Cancer
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SUPPLEMENTAL REFERENCES
1. Nakajima G, Hayashi K, Xi Y, Kudo K, Uchida K, et al. 2006. Non-coding

microRNAs hsa-let-7g and hsa-miR-181b are associated with chemoresponse to
S-1 in colon cancer. Cancer Genomics Proteomics 3:317--24
2. Sempere LF, Christensen M, Silahtaroglu A, Bak M, Heath CV, et al. 2007.
Altered microRNA expression confined to specific epithelial cell subpopulations
in breast cancer. Cancer Res. 67:11612--20
3. Ozen M, Creighton CJ, Ozdemir M, Ittmann M. 2007. Widespread deregulation
of microRNA expression in human prostate cancer. Oncogene 27:1788--93
4. Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, et al. 2007.
Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in
human hepatocellular carcinoma. Cancer Res. 67:6092--99
5. Zhang HH, Wang XJ, Li GX, Yang E, Yang NM. 2007. Detection of let-7a
microRNA by real-time PCR in gastric carcinoma. World J. Gastroenterol.
13:2883--88
6. Wang T, Zhang X, Obijuru L, Laser J, Aris V, et al. 2007. A micro-RNA
signature associated with race, tumor size, and target gene activity in human
uterine leiomyomas. Genes Chromosomes Cancer 46:336--47
7. Lee EJ, Gusev Y, Jiang J, Nuovo GJ, Lerner MR, et al. 2007. Expression
profiling identifies microRNA signature in pancreatic cancer. Int. J. Cancer
120:1046--54
8. Kutay H, Bai S, Datta J, Motiwala T, Pogribny I, et al. 2006. Downregulation of
miR-122 in the rodent and human hepatocellular carcinomas. J. Cell. Biochem.
99:671--78
9. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, et al. 2005. RAS is
regulated by the let-7 microRNA family. Cell 120:635--47
10. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, et al. 2004.
Reduced expression of the let-7 microRNAs in human lung cancers in
association with shortened postoperative survival. Cancer Res. 64:3753--56
11. Lehmann U, Hasemeier B, Christgen M, Müller M, Römermann D, et al. 2007.
Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer.
J. Pathol. 214:17--24
12. Ma L, Teruya-Feldstein J, Weinberg RA. 2007. Tumour invasion and metastasis
initiated by microRNA-10b in breast cancer. Nature 449:682--88
13. Laneve P, Di Marcotullio L, Gioia U, Fiori ME, Ferretti E, et al. 2007. The
MicroRNAs in Cancer
Lee and Dutta
interplay between microRNAs and the neurotrophin receptor tropomyosin-

related kinase C controls proliferation of human neuroblastoma cells. Proc. Natl.
Acad. Sci. USA 104:7957--62
14. Ciafre SA, Galardi S, Mangiola A, Ferracin M, Liu CG, et al. 2005. Extensive
modulation of a set of microRNAs in primary glioblastoma. Biochem. Biophys.
Res. Commun. 334:1351--58
15. Schulte JH, Horn S, Otto T, Samans B, Heukamp LC, et al. 2007. MYCN
regulates oncogenic MicroRNAs in neuroblastoma. Int. J. Cancer 122:699--704
16. Hossain A, Kuo MT, Saunders GF. 2006. Mir-17-5p regulates breast cancer cell
proliferation by inhibiting translation of AIB1 mRNA. Mol. Cell. Biol. 26:8191--
201
17. Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, et al. 2006.
Comprehensive analysis of microRNA expression patterns in hepatocellular
carcinoma and non-tumorous tissues. Oncogene 25:2537--45
18. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, et al. 2007.
MicroRNA-21 miR-21 post-transcriptionally downregulates tumor suppressor
Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.
Oncogene 27:2128--36
19. Iorio MV, Visone R, Di Leva G, Donati V, Petrocca F, et al. 2007. MicroRNA
signatures in human ovarian cancer. Cancer Res. 67:8699--707
20. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. 2007.
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in
human hepatocellular cancer. Gastroenterology 133:647--58
21. Lui WO, Pourmand N, Patterson BK, Fire A. 2007. Patterns of known and novel
small RNAs in human cervical cancer. Cancer Res. 67:6031--43
22. Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, et al. 2007.
MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from
normal pancreas and chronic pancreatitis. JAMA 297:1901--8
23. Fulci V, Chiaretti S, Goldoni M, Azzalin G, Carucci N, et al. 2007. Quantitative
technologies establish a novel microRNA profile of chronic lymphocytic
leukemia. Blood 109:4944--51
24. Bottoni A, Zatelli MC, Ferracin M, Tagliati F, Piccin D, et al. 2007.
Identification of differentially expressed microRNAs by microarray: a possible
role for microRNA genes in pituitary adenomas. J. Cell Physiol. 210:370--77
25. Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY. 2007. miR-21-mediated tumor
growth. Oncogene 26:2799--803
MicroRNAs in Cancer
Lee and Dutta
26. Roldo C, Missiaglia E, Hagan JP, Falconi M, Capelli P, et al. 2006. MicroRNA
expression abnormalities in pancreatic endocrine and acinar tumors are
associated with distinctive pathologic features and clinical behavior. J. Clin.
Oncol. 24:4677--84
27. Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, et al. 2006. Involvement
of human micro-RNA in growth and response to chemotherapy in human
cholangiocarcinoma cell lines. Gastroenterology 130:2113--29
28. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, et al. 2006. Unique
microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer
Cell 9:189--98
29. Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, et al. 2005. MicroRNA
gene expression deregulation in human breast cancer. Cancer Res. 65:7065--70
30. Chan JA, Krichevsky AM, Kosik KS. 2005. MicroRNA-21 is an antiapoptotic
factor in human glioblastoma cells. Cancer Res. 65:6029--33
31. Visone R, Pallante P, Vecchione A, Cirombella R, Ferracin M, et al. 2007.
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
Oncogene 26:7590--95
32. Mertens-Talcott SU, Chintharlapalli S, Li X, Safe S. 2007. The oncogenic
microRNA-27a targets genes that regulate specificity protein transcription
factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer
Res. 67:11001--11
33. Tsuchiya Y, Nakajima M, Takagi S, Taniya T, Yokoi T. 2006. MicroRNA
regulates the expression of human cytochrome P450 1B1. Cancer Res. 66:9090-
-98
34. Mott JL, Kobayashi S, Bronk SF, Gores GJ. 2007. mir-29 regulates Mcl-1
protein expression and apoptosis. Oncogene 26:6133--40
35. Bandrés E, Cubedo E, Agirre X, Malumbres R, Zárate R, et al. 2006.
Identification by Real-time PCR of 13 mature microRNAs differentially
expressed in colorectal cancer and non-tumoral tissues. Mol. Cancer 5:29
36. Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, et al. 2007. p53-
mediated activation of miRNA34 candidate tumor-suppressor genes. Curr. Biol.
17:1298--307
37. Welch C, Chen Y, Stallings RL. 2007. MicroRNA-34a functions as a potential
tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene
26:5017--22
38. Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, et al. 2007.
MicroRNAs in Cancer
Lee and Dutta
Transactivation of miR-34a by p53 broadly influences gene expression and

promotes apoptosis. Mol. Cell 26:745--52
39. Dutta KK, Zhong Y, Liu YT, Yamada T, Akatsuka S, et al. 2007. Association of
microRNA-34a overexpression with proliferation is cell type-dependent. Cancer
Sci. 98:1845--52
40. Tazawa H, Tsuchiya N, Izumiya M, Nakagama H. 2007. Tumor-suppressive
miR-34a induces senescence-like growth arrest through modulation of the E2F
pathway in human colon cancer cells. Proc. Natl. Acad. Sci. USA 104:15472--77
41. Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, et al. 2007. Genetic
unmasking of an epigenetically silenced microRNA in human cancer cells.
Cancer Res. 67:1424--29
42. Shi XB, Xue L, Yang J, Ma AH, Zhao J, et al. 2007. An androgen-regulated
miRNA suppresses Bak1 expression and induces androgen-independent growth
of prostate cancer cells. Proc. Natl. Acad. Sci. USA 104:19983--88
43. Akao Y, Nakagawa Y, Kitade Y, Kinoshita T, Naoe T. 2007. Downregulation of
microRNAs-143 and -145 in B-cell malignancies. Cancer Sci. 98:1914--20
44. Michael MZ, O’Connor SM, van Holst Pellekaan NG, Young GP, James RJ.
2003. Reduced accumulation of specific microRNAs in colorectal neoplasia.
Mol. Cancer Res. 1:882--91
45. He H, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, et al. 2005. The role of
microRNA genes in papillary thyroid carcinoma. Proc. Natl. Acad. Sci. USA
102:19075--80
46. Kluiver J, Poppema S, de Jong D, Blokzijl T, Harms G, et al. 2005. BIC and
miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large
B cell lymphomas. J. Pathol. 207:243--49
47. Eis PS, Tam W, Sun L, Chadburn A, Li Z, et al. 2005. Accumulation of miR-155
and BIC RNA in human B cell lymphomas. Proc. Natl. Acad. Sci. USA
102:3627--32
48. Metzler M, Wilda M, Busch K, Viehmann S, Borkhardt A. 2004. High
expression of precursor microRNA-155/BIC RNA in children with Burkitt
lymphoma. Genes Chromosomes Cancer 39:167--69
49. Pallante P, Visone R, Ferracin M, Ferraro A, Berlingieri MT, et al. 2006.
MicroRNA deregulation in human thyroid papillary carcinomas. Endocr. Relat.
Cancer 13:497--508
50. Chen Y, Stallings RL. 2007. Differential patterns of microRNA expression in
neuroblastoma are correlated with prognosis, differentiation, and apoptosis.
MicroRNAs in Cancer
Lee and Dutta
Cancer Res. 67:976--83

51. Szafranska AE, Davison TS, John J, Cannon T, Sipos B, et al. 2007. MicroRNA
expression alterations are linked to tumorigenesis and non-neoplastic processes
in pancreatic ductal adenocarcinoma. Oncogene 26:4442--52
52. Weber F, Teresi RE, Broelsch CE, Frilling A, Eng C. 2006. A limited set of
human MicroRNA is deregulated in follicular thyroid carcinoma. J. Clin.
Endocrinol. Metab. 91:3584--91
53. le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, et al. 2007. Regulation of
the p27Kip1 tumor suppressor by miR-221 and miR-222 promotes cancer cell
proliferation. EMBO J. 26:3699--708
54. Voorhoeve PM, le Sage C, Schrier M, Gillis AJ, Stoop H, et al. 2006. A genetic
screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ
cell tumors. Cell 124:1169--81
55. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, et al. 2005. A
MicroRNA signature associated with prognosis and progression in chronic
lymphocytic leukemia. N. Engl. J. Med. 353:1793--801
56. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, et al. 2005. miR-15 and
miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. USA
102:13944--49
57. Bottoni A, Piccin D, Tagliati F, Luchin A, Zatelli MC, degli Uberti EC. 2005.
miR-15a and miR-16-1 down-regulation in pituitary adenomas. J. Cell Physiol.
204:280--85
58. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, et al. 2002. Frequent
deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14
in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 99:15524--29
59. Cui JW, Li YJ, Sarkar A, Brown J, Tan YH, et al. 2007. Retroviral insertional
activation of the Fli-3 locus in erythroleukemias encoding a cluster of
microRNAs that convert Epo-induced differentiation to proliferation. Blood
110:2631--40
60. Matsubara H, Takeuchi T, Nishikawa E, Yanagisawa K, Hayashita Y, et al. 2007.
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-
20a in lung cancers overexpressing miR-17-92. Oncogene 26:6099--105
61. Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, et al. 2005. A
polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung
cancers and enhances cell proliferation. Cancer Res. 65:9628--32
62. He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, et al. 2005. A
MicroRNAs in Cancer
Lee and Dutta
microRNA polycistron as a potential human oncogene. Nature 435:828--33

63. Landais S, Landry S, Legault P, Rassart E. 2007. Oncogenic potential of the
miR-106-363 cluster and its implication in human T-cell leukemia. Cancer Res.
67:5699--707
64. Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, et al. 2007.
The let-7 microRNA represses cell proliferation pathways in human cells.
Cancer Res. 67:7713--22
65. Shah YM, Morimura K, Yang Q, Tanabe T, Takagi M, Gonzalez FJ. 2007.
Peroxisome proliferator-activated receptor alpha regulates a microRNA-
mediated signaling cascade responsible for hepatocellular proliferation. Mol.
Cell. Biol. 27:4238--47
66. Lee YS, Dutta A. 2007. The tumor suppressor microRNA let-7 represses the
HMGA2 oncogene. Genes Dev. 21:1025--30
67. Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. 2007. Impaired microRNA
processing enhances cellular transformation and tumorigenesis. Nat. Genet.
39:673--77
68. Brueckner B, Stresemann C, Kuner R, Mund C, Musch T, et al. 2007. The
human let-7a-3 locus contains an epigenetically regulated microRNA gene with
oncogenic function. Cancer Res. 67:1419--23
69. Meng F, Henson R, Wehbe-Janek H, Smith H, Ueno Y, Patel T. 2007. The
MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling
in malignant human cholangiocytes. J. Biol. Chem. 282:8256--64
70. Tagawa H, Karube K, Tsuzuki S, Ohshima K, Seto M. 2007. Synergistic action
of the microRNA-17 polycistron and Myc in aggressive cancer development.
Cancer Sci. 98:1482--90
71. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, et al.
2007. An E2F/miR-20a autoregulatory feedback loop. J. Biol. Chem. 282:2135--
43
72. Venturini L, Battmer K, Castoldi M, Schultheis B, Hochhaus A, et al. 2007.
Expression of the miR-17-92 polycistron in chronic myeloid leukemia CML
CD34+ cells. Blood 109:4399--405
73. Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, et al. 2006.
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat.
Genet. 38:1060--65
74. Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K.
2007. MicroRNA-21 knockdown disrupts glioma growth in vivo and displays
MicroRNAs in Cancer
Lee and Dutta
synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human

gliomas. Cancer Res. 67:8994--9000
75. Löffler D, Brocke-Heidrich K, Pfeifer G, Stocsits C, Hackermüller J, et al. 2007.
Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-
mediated induction of microRNA-21 through a highly conserved enhancer.
Blood 110:1330--33
76. Kulshreshtha R, Ferracin M, Wojcik SE, Garzon R, Alder H, et al. 2007. A
microRNA signature of hypoxia. Mol. Cell. Biol. 27:1859--67
77. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, et al. 2007. MicroRNA-29
family reverts aberrant methylation in lung cancer by targeting DNA
methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. USA 104:15805--10
78. Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A, et al. 2007.
Differential regulation of microRNAs by p53 revealed by massively parallel
sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell
Cycle 6:1586--93
79. Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, et al. 2007.
Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.
Mol. Cell 26:731--43
80. He L, He X, Lim LP, de Stanchina E, Xuan Z, et al. 2007. A microRNA
component of the p53 tumour suppressor network. Nature 447:1130--34
81. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY. 2007.
MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control
of cell proliferation and adhesion-independent growth. Cancer Res. 67:8433--38
82. Hebert C, Norris K, Scheper MA, Nikitakis N, Sauk JJ. 2007. High mobility
group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma.
Mol. Cancer 6:5
83. Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC. 2007.
Coordinate suppression of ERBB2 and ERBB3 by enforced expression of
micro-RNA miR-125a or miR-125b. J. Biol. Chem. 282:1479--86
84. Lee YS, Kim HK, Chung S, Kim KS, Dutta A. 2005. Depletion of human micro-
RNA miR-125b reveals that it is critical for the proliferation of differentiated
cells but not for the down-regulation of putative targets during differentiation. J.
Biol. Chem. 280:16635--41
85. Gillies JK, Lorimer IA. 2007. Regulation of p27Kip1 by miRNA 221/222 in
glioblastoma. Cell Cycle 6:2005--9
86. Galardi S, Mercatelli N, Giorda E, Massalini S, Frajese GV, et al. 2007. miR-221
MicroRNAs in Cancer
Lee and Dutta
and miR-222 expression affects the proliferation potential of human prostate

carcinoma cell lines by targeting p27Kip1. J. Biol. Chem. 282:23716--24
87. Lee DY, Deng Z, Wang CH, Yang BB. 2007. MicroRNA-378 promotes cell
survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1
expression. Proc. Natl. Acad. Sci. USA 104:20350--55
88. Lo AK, To KF, Lo KW, Lung RW, Hui JW, et al. 2007. Modulation of LMP1
protein expression by EBV-encoded microRNAs. Proc. Natl. Acad. Sci. USA
104:16164--69

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Supplemental Material: Annu. Rev. Pathol. Mech. Dis.

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Supplemental Material: Annu. Rev. Pathol. Mech. Dis. 2009.

Supplemental Table 1. MicroRNAs (miRNAs) up- or downregulated in various

tumors relative to normal tissues

miRNA Up/down Cancer Reference

miR-23b Up Uterine leiomyoma 6

Down Colorectal neoplasia 44

Supplemental Table 2. MicroRNAs (miRNAs) that affect the properties of cancer

miRNA +/- Effect on cell growth Note Reference

miR-21 + Decreased apoptosis upon IL-6 removal Myeloma cell line 75

− Increased cytotoxicity and more apoptosis

miR-34a + Inhibition of cell growth in vitro culture and 40

1. Nakajima G, Hayashi K, Xi Y, Kudo K, Uchida K, et al. 2006. Non-coding

interplay between microRNAs and the neurotrophin receptor tropomyosin-

Transactivation of miR-34a by p53 broadly influences gene expression and

Cancer Res. 67:976--83

microRNA polycistron as a potential human oncogene. Nature 435:828--33

synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human

and miR-222 expression affects the proliferation potential of human prostate

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