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Original Paper
Neuropsychobiology 2004;50:102107
DOI: 10.1159/000077947
Hostility-Aggressiveness, Sensation
Seeking, and Sex Hormones in Men:
Re-Exploring Their Relationship
Anton Aluja a Rafael Torrubia b
a University
Key Words
Luteinizing hormone W Aggressiveness W Testosterone W
Sensation seeking W Sex hormone-binding globulin
Aggression and Verbal Aggression obtained significantly higher scores in SHBG and TT. These findings support
Zuckermans personality model for the sensation-seeking trait.
Copyright 2004 S. Karger AG, Basel
Abstract
To evaluate the relationship between sex hormones and
aggressiveness, hostility and sensation seeking we studied 30 healthy males. Using a standardised technique of
radioimmunoassay, we obtained blood values of luteinizing hormone (LH), follicle-stimulating hormone (FSH),
17-estradiol (E2), total testosterone (TT), sex hormonebinding globulin (SHBG) and the free androgen index
(FAI). Personality was evaluated by the Buss-Durkee
Hostility Inventory and the Sensation-Seeking Scale,
form V. The results showed a lack of significant correlations between the measures of aggressiveness-hostility
and hormones. Nevertheless, Spearman and Pearson
correlations between Sensation Seeking and testosterone were positive and significant after controlling for
age. Considerably higher correlations were obtained after controlling for LH and SHBG. A group of subjects with
high scores in a factor made up of Experience Seeking,
Disinhibition and Boredom Susceptibility obtained significantly higher scores on TT and FAI. Subjects with
high scores in a factor made up of Assault, Indirect
ABC
Fax + 41 61 306 12 34
E-Mail karger@karger.ch
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Introduction
A. Aluja
Department of Pedagogy and Psychology
University of Lleida, Complex de la Caparrella, s/n
ES25192 Lleida (Spain)
Tel. +34 973 702326, Fax +34 973 702305, E-Mail aluja@pip.udl.es
Method
Sample
The sample consisted of 30 males who volunteered to participate
in the study; they were recruited among hospital sanitary staff and
final year undergraduate medical students. Age ranged between 21
and 40 years (mean age 27.9 B 4.9 SEM). All measures were
collected anonymously. Two questionnaires had missing data, so
both were excluded from statistical analyses. Furthermore, SHBG
measures from two participants were missing. Finally, one participant was also excluded because he had an abnormal FSH level
(25 mU/ml).
Personality Measures
The Spanish version of the Sensation-Seeking Scale, form V [28]
has 40 items and includes the subscales of Thrill and Adventure
Neuropsychobiology 2004;50:102107
103
Seeking (TAS), Experience Seeking (ES), Dis, Boredom Susceptibility (BS), and a total Sensation-Seeking score [29]. Reliability alpha
coefficients were between 0.62 and 0.82, very similar to those
obtained in English-speaking samples [29].
The BDHI has the following subscales: Assault (Ass), Indirect
Aggression (Ind), Negativism (Neg), Resentment (Res), Suspicion
(Sus), Verbal Aggression (Ver), Irritability (Irr) and Guilt [1]. Five of
these scales measure aggression (Ass, Ind, Irr, Neg and Ver) and two
measure hostility (Res and Sus). The Guilt subscale was added subsequently. The inventory was adapted to Spanish by De Flores [30].
The split-half reliability was calculated by means of the SpearmanBrown method, obtaining an index of 0.96.
Blood Samples for Hormone Measures
In order to minimize the pulsatile effects on hormone levels,
blood samples were drawn three times (10 ml ! 3) from the antecubital vein between 08.00 and 09.00 h at 20-min intervals. They were
then pooled and transferred to heparinized tubes and centrifuged.
Supernatant plasma was withdrawn and stored in a freezer (20 )
before proceeding with each determination. These samples were
radioimmunoassayed for LH, FSH, E2 (Medgenix, Brussels, Belgium; note that for the calculation of E2, cases with values lower than
11 were deleted because the sensitivity of the kit only yielded measures above 10 pg/ml), TT (Immunotech, Marseille, France) and
SHBG, measured using the IRMA method (Farmos Diagnostics,
Turku, Finland). The FAI was also calculated with the following formula: [testosterone in nmol/l divided by SHBG in nmol/l] ! 100. To
change the ng/ml TT into nmol/l, it was multiplied by a constant
value of 0.0347 [31]. Kurtosis and Skewness values indicated that
hormone values met distributional assumptions, except for SHBG.
Statistical Evaluations
Firstly, a combined factor analysis of the SSS-V and the BDHI
was performed in order to reduce the number of variables. To examine the association between hormone levels and personality factors,
we used Spearmans correlations to avoid biases from the low size of
the sample and the non-normality of the SHBG distribution. We also
performed partial correlations controlling for age, LH, FSH and
SHBG because of the changes in testosterone level due to those variables. However, non-significant correlations may obscure differences
between high and low scorers. Therefore we additionally used the
non-parametric Mann-Whitney U test (one tailed) to compare hormone levels in extreme groups. We performed all analyses using the
Statistical Package for the Social Science, edition 10.
Results
104
Neuropsychobiology 2004;50:102107
Aluja/Torrubia
Table 1. Spearmans rho (#) and partial correlations between personality factors and hormones (correlations including 17-estradiol were
only calculated for the 17 cases with values 1 10 pg/ml)
LH
FSH
E2
SHBG
TT
FAI
Aggressivity factor
Hostility factor
(#)
Controlling for
(#)
Controlling for
(#)
SSF
Age
AggF
Age
0.05
0.04
0.40
0.11
0.35
0.40*
0.11
0.05
0.26
0.10
0.36
0.40*
Age +
LH
0.01 0.21
0.26
0.33 0.28 0.30
0.08
0.08
0.11
0.47** 0.36 0.45* 0.39*
0.46** 0.42*
0.49*
AggF +
age
0.11
0.05
0.27
0.09
0.38
0.41*
0.03 0.10
0.23 0.07 0.06
0.33 0.43 0.22
0.28 0.22 0.20
0.33 0.28 0.26
0.14 0.18 0.16
SSF +
age
Controlling for
HosF age
0.06
0.12
0.29
0.16
0.00
0.12
0.03
0.23
0.35
0.27
0.15
0.02
0.23
0.36
0.27
0.16
0.01
SSF +
age
LH = Luteinizing hormone; FSH = follicle-stimulating hormone; E2 = 17-estradiol; SHBG = sex hormone-binding globulin; TT = total testosterone; FAI = free androgen index.
* p ! 0.05; ** p ! 0.01.
Discussion
Neuropsychobiology 2004;50:102107
105
Acknowledgements
This research was supported by grants from the Comissio Interdepartamental de Recerca i Innovacio Tecnolgica (CIRIT) of the
Autonomous Government of Catalonia, Spain. We also thank Dr.
M.J. Martnez de Osaba, endocrinologist at Barcelona Clinical Hospital, and Dr. L.F. Garca for his help in the statistical analysis.
References
1 Buss A, Durkee A: An inventory for assessing
different kinds of hostility. J Consult Clin
Psych 1957;21:343349.
2 Persky H, Smith KD, Basu GK: Relation of
psychological measures of aggression and hostility to testosterone production in man. Psychosom Med 1971;33:265277.
3 Meyer-Bahlburg HFL, Boon DA, Sharma M,
Edwards JA: Aggressiveness and testosterone
measures in man. Psychosom Med 1974;36:
269274.
106
Neuropsychobiology 2004;50:102107
Aluja/Torrubia
11 Harris JA: Review and methodological considerations in research on testosterone and aggression. Aggress Violent Behav 1999;4:273291.
12 Aromki AS, Lindman RE, Ericksson CJP:
Testosterone, aggressiveness, and antisocial
personality. Aggress Behav 1999;25:113123.
13 Gerra G: Neurottransmitter-neuroendocrine
responses to aggression: Personality influences;
in Raine A, Brennan P (eds): Biosocial bases of
violence. NATO ASI Series. Life Sciences,
292.1997 (pp. 333335). NY: Plenum Press.
14 Archer J: The influence of testosterone on human aggression. Br J Psychol 1991;82:128.
15 Daitzman R, Zuckerman M, Sammelwitz P,
Ganjam V: Sensation seeking and gonodal hormones. J Biosoc Sci 1978;10:401408.
16 Daitzman R, Zuckerman M: Disinhibitory sensation seeking, personality and gonadal hormones. Pers Individ Differ 1980;1:103110.
17 Galligani N, Renck A, Hansen S: Personality
profile of men using anabolic androgenic steroids. Horm Behav 1996;30:170175.
18 Bogaert, AF, Fisher WA: Predictors of university mens number of sexual partners. J Sex Res
1995;32:119130.
19 Rosenblitt JC, Soler H, Johnson SE, Quadagno
DM: Sensation seeking and hormones in men
and women: Exploring the link. Horm Behav
2001;40:396402.
Neuropsychobiology 2004;50:102107
107