Documentos de Académico
Documentos de Profesional
Documentos de Cultura
G R A D U A T E
S C H O O L
A T
S H A R I N G K N O W L E D G E . C R EAT I N G O P P O RT U N I T Y.
N I H
FALL SEMESTER
July 1-Aug. 23
Aug. 19
Aug. 23
Aug. 29 Sept. 7
Sept. 8 Oct. 8
Sept. 12
Sept. 23
Oct. 8
Oct. 10
Oct. 21
Nov. 10
Nov. 11
Nov. 24
Dec. 16
Dec. 30
Jan 4
Jan. 9 18
Jan. 19 Feb. 18
Jan. 24
Feb. 4
Feb. 18
Feb. 20
Mar. 2
April 13
May 11
Online registration
Last day for mail registration
Open House*
Walk-in Registration
Late Walk-in Registration ( ($10.00 late registration fee)
Classes begin
Last day of course transfer -without fee
Last day to register
Columbus Day No classes
Last day to withdraw and Transfer
Last day to change status (credit/audit or vice versa)**
Veterans Day - No classes
Thanksgiving DayNo classes
Close of Fall Semester***
The Registrars Office and Bookstore will be open 5-8 p.m. during the first week of classes, in addition to regular hours.
* PLEASE JOIN US FOR OUR OPEN HOUSE ON AUGUST 23, 2011 FROM 4:00PM-7:00PM AT THE SOCIAL AND ACADEMIC CENTER,
LOCATED AT 9101 OLD GEORGETOWN ROAD, BETHESDA. WALK-IN REGISTRATION WILL BE ACCEPTED.
** Please call Registrars office for deadline to change status or withdraw from courses that are not on the 14 or 16 week schedule.
*** Class meetings that are canceled for any reason will be made up.
Registration by Mail
Advance registration is possible by mail by completing and sending the attached form with tuition check or contract to FAES at NIH, 1 Cloister Court,
(Bldg. 60, Suite 230) until August 19.
Introducing Online Registration for FALL 2011 semester July 1 August 23, 2011. Students who have taken previous FAES courses (including BIOTRAC) will need to email Priyanka Basa at basap@mail.nih.gov to request a new password. New students can create an account at www.
faes.org and follow the online instructions on how to register between July 1st - August 23rd.
Online registrations paying with check, Purchase Order or Training Nomination form will not be completed until payment is received (mail or
walk-in) within five (5) business days. FAES Faculty and family members must register by mail or in person.
Do not send registration card without some form of payment.
Please note: Asking your institute to pay for training does not constitute registration. If you are registering by mail, you need to send the Training
NominationSF182 Form (signed) and a Registration Card (see deadline for mail registration). If you are registering in person, you need to bring the
Training NominationSF182 Form and a Registration Card (see dates for in-person registration).
If you are paying your tuition with a credit card, (Visa, MC or Discover) you may fax your registration to 301-402-0174 up until August 19.
Please note: SF182 forms are available from your Administrative Officer.
Registration in Person
Registration in person will be held in Bldg. 60, Suite 230 in accordance with the dates below.
FALL
SPRING
Catalog Information
Catalogs may be obtained free of charge in the FAES Offices (Bookstore Bldg. 10, Room B1-L-101, Business Office Bldg. 10, Rm. B1-C-18, or
Administrative Office Bldg. 60, Suite 230) or visit our website at www.faes.org
For Further Information
FAES Graduate School 301-496-7976
Business Office 301-496-8064
Bookstore 301-496-5272.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
FAES
Catalog
2011-2012
Dean
Constance Tom Noguchi, Ph.D.
Registrar
Audrey L. Lyons
Postal Address:
One Cloister Court, Suite 230
Bethesda, Maryland 20814-1460
Inter-Office Address:
Building 60
Suite 230
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Ex-Officio Member
Administrative Staff
Alexis Alleyne, B.A ...........................................................................................................................................................Insurance Program/HR Manager
Nancy Avent .................................................................................................................................................................................... Insurance Supervisor
Priyanka Basa, B.S...............................................................................................................................................................Communications Coordinator
Shawna Clay, A.A ................................................................................................................................................................................ Insurance Assistant
Carline Coote, B.S .............................................................................................................................................................................Conference Manager
Shawn Foreman ....................................................................................................................................................................................... Staff Accountant
Jaleh Gormley, B.A ................................................................................................................................................................................... Staff Accountant
Audrey Lyons ........................................................................................................................................................................................................Registrar
Manny Mekonnen, B.S ........................................................................................................................................................................Bookstore Assistant
Rose McNeeley, B.S. ....................................................................................................................................................................................SAC Manager
Darlissa Musgrove ...............................................................................................................................................................................Bookstore Assistant
Elizabeth Perkins, B.A ......................................................................................................................................................................... Bookstore Manager
Marie Perng, B.A., CPA ......................................................................................................................................................................... Senior Accountant
Jennifer Schultze, B.S.......................................................................................................................................................................... Insurance Assistant
Paul Schwobel, CPA ............................................................................................................................................................................................Controller
Beatrice Sonnenberg ............................................................................................................................................................................ Assistant Registrar
Danita Waker, MPH ..................................................................................................................................................................... Administrative Assistant
Melissa Zhong, B.A. ............................................................................................................................................................................ Insurance Assistant
This is the catalog for the 2011-2012 Academic Year. A schedule giving only the day and hour for Spring 2012 courses will be published.
Please retain this catalog for all other information; copies are limited in number.
ii
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Table of Contents
Fall 2011 Semester Schedule ........................................................................................................................................................................................1
Regulations and Procedures .........................................................................................................................................................................................3
Lists of Board Review Courses ...................................................................................................................................................................................38
Biochemistry and Biophysics .......................................................................................................................................................................................6
BIOC 301
Biochemistry I
BIOC 302
Biochemistry II
BIOC 315
Protein Biochemistry
BIOC 316
Structure and Function of Biological Macromolecules
BIOC 433
Current Methodology in Nucleic Acid Structure and Function Research
BIOC 505
Cell Membrane and Intracellular Trafficking
BIOC 527
Biochemistry and Metabolism of Lipids
BIOC 533
The Molecular and Cellular Basis of Intercellular Communication
BIOC 539
Recent Discoveries in Molecular Biology
Bioinformatics ................................................................................................................................................................................................................ 8
BIOF 309
Introduction to Python
BIOF 312
Introduction to Perl
BIOF 411
Introduction to Genomics
BIOF 429
Practical Bioinformatics
BIOF 502
Medical Genomics for Clinicians and Researchers
BIOF 518
Theoretical and Applied Bioinformatics
BIOF 537
Computational Biology
BIOF 538
Biological Database Design
BIOF 552
Medical Genomics for Clinicians and Researchers
Biology and Genetics ..................................................................................................................................................................................................10
BIOL 101
Introductory Biology
BIOL 102
Introductory Biology-Genetics
BIOL 262
Molecular Approaches to Studying Diseases
BIOL 317
Molecular Cell Biology
BIOL 319
Stem Cells and Their Niches
BIOL 325
Basic Human Neuroanatomy
BIOL 327
Modern Developmental Biology
BIOL 338
Epigenetics and Medical Disorders
BIOL 435
Current Trends in the Neurobiology of Mental Illness
BIOL 504
Developmental and Synaptic Neuroplasticity
GENE 415
Control of Gene Expression
GENE 500
Introduction to Medical Genetics
GENE 505
Embryology, Developmental Biology and Human Malformations
GENE 510
Genetic Counseling: Professional Topics Seminar
GENE 514
Current Concepts in Clinical Molecular Genetics and Molecular Diagnostics
GENE 644
A Review of Medical Genetics
Biotechnology (BIO-TRAC) ..........................................................................................................................................................................................14
TRAC 1
Biotechnology Techniques
TRAC 2
Recombinant DNA Methodology I
TRAC 3
Recombinant DNA Methodology II
TRAC 4
Cellular Immunology: Principles and Methods
TRAC 5
Separation Techniques
TRAC 6
Cellular and Molecular Basis for Understanding, Diagnosis and Therapy of Cancer
TRAC 7
Animal and Human Cell Culture: Methods and Applications
TRAC 8
Immunochemistry and Monoclonal Antibody Production
TRAC 9
Polymerase Chain Reaction and Molecular Hybridization Technology
TRAC 10
Protein DNA Interactions: Gene Specific and Epigenetic Regulation of Expression of the Mammalian Genome
TRAC 11
Genome Analysis
TRAC 12
Transgenic Technology: Methods and Application
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
iii
TRAC 15
TRAC 16
TRAC 18
TRAC 19
TRAC 20
TRAC 21
TRAC 22
TRAC 23
TRAC 24
TRAC 25
TRAC 26
TRAC 28
TRAC 29
TRAC 30
TRAC 31
TRAC 32
TRAC 33
TRAC 34
TRAC 35
TRAC 36
TRAC 37
TRAC 38
TRAC 39
TRAC 40
TRAC 41
TRAC 42
TRAC 43
iv
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Languages..................................................................................................................................................................................................................... 29
CHIN 101
Introduction to Chinese
CHIN 102
Intermediate Chinese
CHIN 301
Practical Chinese I
CHIN 302
Practical Chinese II
CHIN 401
Chinese Literature I
CHIN 402
Chinese Literature II
ENGL 105
Fundamental English Conversation I
ENGL 108
Fundamental English Conversation II
ENGL 205
Intermediate English I
ENGL 207
Intermediate English II
ENGL 302
Advanced English Conversation I
ENGL 304
Advanced English Conversation II
ENGL 305
Advanced English Structure I
ENGL 306
Advanced English Structure II
FRCH 101
French for Beginners I
FRCH 102
French for Beginners II
FRCH 201
Intermediate French I
ITAL 101
Italian for Beginners I
ITAL 102
Italian for Beginners II
JAPN 101
Introduction to Japanese I
JAPN 102
Introduction to Japanese II
JAPN 203
Intermediate Japanese I
JAPN 204
Intermediate Japanese II
JAPN 305
Advanced Japanese I
JAPN 306
Advanced Japanese II
JAPN 407
Advanced Japanese III
JAPN 408
Advanced Japanese IV
SPAN 101
Spanish for Beginners I
SPAN 102
Spanish for Beginners II
SPAN 203
Intermediate Spanish I
SPAN 204
Intermediate Spanish II
SPAN 208
Spanish for Healthcare Providers
Mathematics, Epidemiology & Statistics .................................................................................................................................................................. 33
MATH 127
Elementary Calculus I
MATH 128
Elementary Calculus II
STAT 200
Introduction to Experimental Statistics
STAT 317
Introduction to Epidemiology
STAT 318
Statistical Methods in Epidemiology
STAT 321
Methodology in Clinical Trials
STAT 322
Intermediate Epidemiology
STAT 435
Genetic Epidemiology
STAT 500
Statistics for Biomedical Scientists
STAT 518
Categorical Data Analysis
STAT 525
Nonparametric and Robust Methods
STAT 529
Survival Data Analysis
Medicine and Physiology.............................................................................................................................................................................................35
MEDI 211
Introduction to the Principles of Endocrinology
MEDI 217
Human Physiology I: Neural, Cardiovascular, Pulmonary, Sensory, and Neonatal Systems
MEDI 302
Introduction to Chinese Acupunctology
MEDI 303
Regenerative Medicine: Considering Applications and Treatments
MEDI 316
Biology of Cancer
MEDI 326
Introduction to Global Health
MEDI 329
Advanced Topics in Cancer: Tumor Microenvironment and Metastasis
MEDI 507
Inborn Errors of Metabolism
MEDI 522
Neural Immune Interactions in Health and Disease
MEDI 550
Introduction to the Principles of Clinical Research
MEDI 552
Demystifying Medicine for Ph.D. Students, Fellows and Staff
Medical Subspecialty Review Courses.......................................................................................................................................................................37
MEDI 723
A Review of Endocrinology: Diagnosis and Treatment
MEDI 725
Psychopharmacology and Neuroscience Course: Update 2011
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
NOTES:
In the case of a full year course, registration may be made for the entire year or for each semester separately. Failure to reregister for the
second semester could result in cancellation of that semester due to lack of enrollment.
Classes are not held on days when government offices are closed early or all day due to hazardous weather conditions, or when evening weather
conditions are predicted to worsen. If in doubt, contact the school office (301-496-7976) or the instructor.
Biotechnology (TRAC) courses do not follow semester schedules. For exact dates, refer to course descriptions.
vi
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
vii
viii
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Title
Instructor
Time
Tuition
Introductory Biochemistry I
Introduction to Python (7 weeks Sept. 26 Nov. 7)
Epigenetics and Medical Disorders (7 weeks Oct. 17-Dec.16)
Organic Chemistry I (Wed. required)
Introduction to Chinese
Fundamental English I
Advanced English Conversation I
GRE Review (7 weeks)
Principles and Applications of Magnetic
Resonance Imaging (MRI) in Biomedicine
Elementary Calculus
Introduction to Chinese Acupunctology
Introductory and General Microbiology
Introduction to Molecular Virology
Introduction to Experimental Statistics I
Survival Data Analysis
Tools for Technology Transfer
(Class will be held at Executive Boulevard)*
Introductory Toxicology
Ho
Cherry
Gebert
Freedberg
Lum
Miller
Miller
Ou
Komlosh
5:30-8:40
5:30-7:40
5:30-7:40
5:30-7:00
5:30-8:40
4:15-7:10
7:10-10:05
5:30-7:40
5:30-7:40
$435
145
145
435
435
435
435
145
290
Momenan
Wu
Tang
Arya
Ghebregiorgis
Hung
Goldstein
5:30-8:40
5:30-8:40
5:30-8:40
5:30-7:40
5:30-8:40
5:30-8:40
5:30-7:40
435
435
435
290
435
435
290
Mitkus
5:30-7:40
290
Title
Instructor
Time
Introduction to Genomics
Basic Human Neuroanatomy (Thur. Required)
Current Trends in the Neurobiology of Mental Illness
General Chemistry I
Advances in Synthetic Organic Chemistry I
Practical Chinese
Fundamental English Conversation I
Intermediate English I
Advanced English Conversation I
French for Beginners I
Intermediate French I
Introduction to Medical Genetics I
Art Songs: Chamber Music with Words
Basic Principles of Immunology and
Hypersensitivity (also offered Wed.)
Communicating Science to Lay Audiences
Introductory Physics I
Introduction to Epidemiology
Methodology in Clinical Trials
Statistics for Biomedical Scientists I
International Strategic Partnering and Business Development
(Class will be held at Executive Boulevard)*
Business Finance and Accounting Principles
for Scientists Introduction (Class will be held at Executive Boulevard)
Capstone Course in Technology Transfer
(Class will be held at Executive Boulevard)*
Malone
Herkenham
Zarate
Metaferia
Appella
Lum
Miller
Jorgenson
Miller
King
Banu
Hart
Epstein/Krash
Finerty
5:30-840
5:30-7:00
5:30-8:40
5:30-8:40
5:30-7:40
5:30-8:40
7:10-10:05
5:30-8:40
4:15-7:10
5:30-8:40
5:30-8:40
5:30-7:40
7:00-9:00
5:30-7:40
$435
435
435
435
290
435
435
435
435
435
435
290
290
290
Kwon/Nelson
Eresian
Patel
Rosenberg
Shah
Khanna
5:30-7:40
5:30-8:40
5:30-8:40
5:30-8:40
5:30-8:40
5:30-7:40
290
435
435
435
435
290
Reichman
5:30-7:40
290
Ferguson//Provorny 5:30-8:40
435
TUESDAY
Course
BIOF 411
BIOL 325
BIOL 435
CHEM 101
CHEM 341
CHIN 301
ENGL 105T
ENGL 205
ENGL 302T
FRCH 101
FRCH 201
GENE 500
GENL 161
IMMU 403T
PBHL 507
PHYS 201
STAT 317
STAT 321
STAT 500
TECH 567
TECH 575
TECH 607
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Tuition
WEDNESDAY
Course
BIOC 527
BIOF 429
CHEM 211
CHEM 220
CHIN 401
ENGL 305
GENE 505
GENL 163
IMMU 403W
MEDI 303
MEDI 329
PBHL 517
PHYS 245
SPAN 101
TECH 503
Title
Instructor
Time
Tuition
Francis
Bhagwat
Freedberg
Nyden
Lum
Miller
Biesecker
Momenan
5:30-8:40
5:00-8:00
5:30-7:00
5:30-7:40
5:30-8:40
4:15-7:10
5:30-6:30
5:30-7:30
$435
290
435
290
435
435
145
145
Finerty
5:30-7:40
290
Hunsberger
5:30-7:40
290
Rittler/
Shuman Moss
Hafner-Eaton
Eresian
5:30-7:30
290
5:30-8:40
5:30-7:40
435
145
Rodriguez
Provorny/Vepa
5:30-7:40
5:30-7:40
290
290
Title
Instructor
Time
Computational Biology
Molecular Cell Biology
Basic Human Neuroanatomy (Tues. required)
Molecular and Cellular Mechanisms of Immunity I
Italian for Beginners
Introduction to Japanese I
Introduction to the Principles of Endocrinology
Human Physiology I: Neural, Cardiovascular, Pulmonary,
Sensory & Neonatal Systems
Introduction to Applied Public Health Nutrition
Strategies to Improve Population Health
Principles of Clinical Pharmacology I (Sept. 1 Dec 15)
Intermediate Spanish I
Genetic Epidemiology
Biomedical Business Development for
Scientists (Class will be held at Executive Boulevard)*
Negotiation Workshop
Medical Product Development
(Class will be held at Executive Boulevard)*
Busby
Espey
Herkenham
Henkart
Tecuta
Moorman
Celi
Sinnarajah
5:30-8:50
5:30-7:50
5:30-7:00
5:30-7:50
5:30-8:50
5:30-8:50
5:30-7:50
5:30-7:50
$435
290
435
290
435
435
290
290
McDowell
5:30-7:50
290
Lertora
Roman
Major
Ferguson/Salagaller
6:30-7:45
5:30-8:50
5:30-8:50
5:30-7:50
290
435
435
290
Muroff
Smith
5:30-7:50
5:30-7:50
290
290
Title
Instructor
Time
Biesecker/Madeo
Truman
2:30-5:30
2:00-4:00
THURSDAY
Course
BIOF 537
BIOL 317
BIOL 325
IMMU 521
ITAL 101
JAPN 101
MEDI 211
MEDI 217
PBHL 511
PHAR 500
SPAN 203
STAT 435
TECH 565
TECH 579
TECH 584
Tuition
FRIDAY
Course
GENE 510
TECH 587
Tuition
$580
290
Please note: During the semester, a number of Monday and Thursday classes are not held because of Federal holidays. Monday and Thursday
class times have been adjusted accordingly.
* Please note: Students attending classes at Executive Boulevard will be responsible for paying parking fees directly to the attendant.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
The Foundation for Advanced Education in the Sciences is organized to foster scientific research and education by facilitating communication among scientists and by sponsoring formal instruction in the sciences. It was founded by scientists who believe learning,
research and teaching are mutually reinforcing processes essential to the evolution of science; that research receives a powerful impetus from the activities and enterprise of scientists who combine and interchange roles as student, investigator and teacher; and that
throughout the search for truth, education must be a continuing, central theme.
Sponsorship and management of The FAES Graduate School at NIH represent one aspect of the Foundations educational activities. We
are especially grateful to the outstanding scientists and teachers who have taught and continue to teach these courses.
Entrance Requirements
Entrance requirements differ with the level of the course for which the
student is registering. Undergraduate courses, in general, are open to
persons who are graduates of high school or equivalent, or who qualify
for the course because of satisfactory work experience. For admission
to more advanced courses, college work in the same or related field is
specified or understood. For some courses, definite prerequisites may
be stated. Registration for the second half of a year course requires
completion of the first semester or permission of the instructor.
When consent of the instructor is given as a necessary prerequisite
for a course, the instructor must be consulted before registration.
Any student who does not have a clear financial record with FAES will
not be permitted to register.
Accreditation
The FAES Programs operate with the approval of the Maryland Higher
Education Commission.
Transfer of Credit
(see Certificate in Technology Transfer Program)
FAES courses do not currently lead to degrees.
A student should not assume that credit for work done in FAES courses
at NIH will be granted by any particular college or university, although
such credit is generally given. The student who wishes to work for an
undergraduate or higher degree should consult in advance the dean or
departmental chairman of the institution from which he expects to receive
the degree, and receive approval for any courses in the FAES Programs
at NIH that he plans to use toward his degree.
Courses in the FAES Programs at NIH do not include laboratory work
unless this activity is stated specifically in the course description.
The Office of Personnel Management accepts certain course work in
these programs for examination and qualification purposes, on the same
basis as that from full-time colleges and universities.
The Master of Public Health Program at The George Washington
University recognizes certain courses within the FAES as substitutes for
those offered in the MPH Program. Successful completion of those FAES
courses allow students to apply for transfer of credit in the MPH Program.
For further information about the MPH Program and currently eligible
FAES courses, contact the Program office at 202-994-2807.
Registration
The registration period is shown on the school calendar on the inside
front cover. Registration is not complete until the required fees have been
paid. Registration for full year courses may be made for the entire year or
for each semester separately; failure to reregister for the second semester
could result in cancellation of that semester due to lack of enrollment.
Courses that are not on the 14 or 16 week semester schedule may
have a different registration period.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Financial Assistance
The Gerald D. Aurbach Memorial Scholarship Fund (Guest
Researchers)/FAES Student Scholarship Fund (Postbacs and Graudate
Students) provides a limited number of full or partial scholarships for
students at the NIH with restricted income. The deadline for applications
is the same as that for mail registration. Students interested in further
information should call 301-496-7976. The Pierre Renault Memorial
Scholarship Fund (sponsored by R/M Nardone Associates Inc.) provides
financial aid for qualified Biotechnology students.
Course Load
Students employed full-time may carry more than two courses only
with the permission of the Registrar.
Fees
Tuition is $145.00 per credit (except for certain courses, e.g.
biotechnology courses and 600 level courses. See schedule of classes
for specific tuition charges). Students 65 years and over are eligible for
50% reduced tuition (for evening classes only).
Late Registration Fees: $10.00 late fee through the 4th week of the
term. Registration is not possible after the 4th week. See calendar for
dates.
Late Transfer Fee: There is a $3.00 late transfer fee for each course.
See calendar for dates.
Withdrawal Fee: See paragraph on Withdrawals and Refunds.
Change from Credit or Audit: A student may request from the Registrar
that his status in a course be changed from credit to audit, or vice versa,
provided the request is submitted in writing and is accompanied by the
$3.00 fee, no later than the end of the ninth week of the fall semester
(see Calendar) and no later than the twelfth week of the semester
Spring Semester*. Reporting a credit-audit change to the instructor
does not constitute an official change. Students not paying their own
fees must submit written approval from their Administrative Offices
when requesting a change. Grades: At the close of the semester,
students taking courses for credit will receive written notice by mail of
grades received. Upon request of the student or sponsor, grades will be
forwarded to Personnel or University office. The following grades are used:
AExcellent
BGood
CAverage
DPassable
FFailure
I**Incomplete
AUDAuditor
**The symbol I indicates that the required course work has not been
completed, and may be changed to another grade if the student provides
the instructor with a satisfactory explanation, and arranges to complete
the work within a reasonable time.
Transcript of Credit
Students may obtain official transcripts for their Personnel files or for
other purposes by requesting them in writing from the Registrar, with the
payment of $5.00 per copy. No transcripts are issued during registration.
Change of Status Fee: There is a $3.00 fee for a change from credit
to audit or vice versa.
From the time of registration through the second week of term: tuition
less $20.00 per course.
Transcript Fee: A fee of $5.00 per transcript will be charged for the
first 10 copies. Additional transcripts will be charged at $3.00 per copy,
whenever multiple transcripts are requested at one time. A students
record will be supplied on the regular Foundation form. Fee must
accompany request.
During third and fourth weeks of term: 60% of total tuition will be
refunded.
Returned Check Fee: There will be a $25.00 fee for checks returned
from the bank for any reason.
Attendance at Classes
A student may not attend classes until registration has been
completed and fees due are paid. The student is expected to attend all
class sessions, and even unavoidable absences do not relieve him/her
from responsibility for work assigned during his/her absence.
During fifth and sixth weeks of term: 40% of total tuition will be refunded.
After the sixth week: no refund, and withdrawal is not possible.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Courses of Instruction
Courses sponsored by FAES as a part of its regularly established
curriculum are listed for 2011-2012 in the following pages by departments
of instruction.
The words Fall and Spring show the semester in which the course
is offered. ***The word Year indicates that the course is a two-semester
course. The number of credits shows the value of the course in semester
hours. One credit corresponds to 16 standard contact hours.
Courses numbered from 1 to 99 are intended for general adult
education and may not be of college level.
Courses numbered from 100 to 199 are offered at lower college level
(Freshman/Sophomore).
Courses numbered from 200 to 299 are intended for upper college
level, requiring at least one college level prerequisite (Junior/Senior).
Courses numbered from 300 to 399 are for the senior and graduate
levels and are open to both (Post-baccalaureate or graduate student).
Book Service
Courses numbered from 400 to 499 are offered for graduate students
and qualified seniors.
Courses numbered from 500 and above are for graduate and
professional students only; where indicated, they may be open to others
who qualify.
Phone: 301-496-5272
Every effort has been made to describe the level and content of each
course as accurately as possible. Should there be any uncertainty on
the part of the student, it is his responsibility to consult the instructor for
clarification.
EXTENDED HOURS
Tuesday, September 6
Tuesday, January 17
5:00 p.m. 7:00 p.m.
Extension Programs
In efforts to enrich the intellectual environment for the NIH community,
to promote science and the welfare of scientists, the Foundation sponsors
the following activities (for further information call 301-496-7976):
1. FAES MembershipMembership in the FAES is open to anyone with
an interest in the promotion of scientific research and education. An
annual fee of $15 entitles the member to vote for representation on the
Board of Directors, to a 5% discount on Bookstore purchases, and use
of the Social and Academic Center. (See paragraph 5).
2. Cultural ProgramsIn the belief that research and advanced education
flourish best in a broad intellectual climate, the FAES encourages and
sponsors nonscientific programs of interest to the NIH community.
FAES sponsors the Manchester String Quartet for their monthly
Monday noontime concerts at the NIH Masur Auditorium. Through
gifts and purchases, the FAES has assembled a collection of graphics
and paintings, which are on display in the cafeterias of the NIH. Other
cultural activities are being planned for the future.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Henry Levin
Gail Seabold
Jean Tiong
Roberto Weigert
John E. Weldon
Wei Yang
BIOC 316
Structure and Function of
Biological Macromolecules
BIOC 301
Fall, 3 credits
Biochemistry I
Mitchell Ho*
Gail Seabold
Jean Tiong
John E. Weldon
BIOC 301and BIOC 302 are comprehensive survey of biochemistry at the graduate
level. BIOC 301 will cover structure and function of biological macromolecules,
as well as topics on metabolic pathways including glycolysis, citric acid cycle
and oxidative phosphorylation. It will also cover the current methods used in
biochemistry and medicine.
Textbook: Lehninger Principles of Biochemistry, 5th edition.
Course website: http://tech.groups.yahoo.com/group/bioc300/
BIOC 302
Spring, 3 credits
Biochemistry II
Mitchell Ho*
Gail Seabold
Jean Tiong
John E. Weldon
Protein Biochemistry
Spring, 2 creditsP
Paul K. Goldsmith
The course materials cover concepts, methods, and practical procedures for
the development of analytical reagents for the isolation, characterization and
quantitative analysis of proteins. The course is designed for researchers who
have not had great experience with proteins. The lectures will begin with analytical
assay theory. Protein determination methods will be discussed. The lectures will
then focus on the production of peptide specific antibodies for use as analytical
reagents. Methods such as electrophoresis, western blotting, low and high
pressure chromatography, immunoprecipitation and ELISA will then be discussed.
Protein derivitization, protocols for mass spec analysis will also be presented in
the lectures.
There are no exams in the course. Each student will be required to evaluate and
present a paper to the class which utilizes one of the techniques that have been
Wei Yang*
David Davies
BIOC 315
BIOC 433
Spring, 2 credits
BIOC 505
Cell Membranes and Intracellular
Trafficking
Spring, 2 credits
Leonid V. Chernomordik*
Roberto Weigert
The course will consider modern concepts relating to the structure and function of
cell membranes. Starting from the physical properties of membranes, the course
will examine membrane biogenesis, membrane dynamics, and intracellular
trafficking. Examples will be drawn from specific membrane functions in the
various organelles. Topics will include nuclear transport, ER to golgi transport,
endocytosis, carbohydrate and lipid trafficking.
Minimum of 15 students must register for course to be held.
Prerequisite: CHEM 220 and BIOC 300 or equivalent.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
BIOC 527
Fall, 3 credits
Fouad Francis
The objectives of this course are to address the in vivo and in vitro biochemical,
physiological and clinical characteristics of lipids and lipoproteins. The first portion
of the course will involve topics that include properties of lipids, lipid markers of
subcellular membranes, and lipid, prostaglandins and lipoprotein metabolism. The
second portion of the course will consider the current concepts relating to specific
lipid functions, lipid-protein interaction, and disorders of lipid metabolism.
Prerequisite: BIOC 300 or equivalent, and permission of instructor.
BIOC 533
Joan Cmarik
BIOF 312
Introduction to Perl
(See page 8)
BIOF 411
Introduction to Genomics
(See page 8)
BIOF 429
Practical Bioinformatics
(See page 8)
BIOF 518
Theoretical and Applied Bioinformatics
(See page 9)
BIOF 537
Computational Biology
(See page 9)
BIOF 538
Biological Databases Design
(See page 9)
Prerequisite: M.D., Ph.D., prior course work (e.g. MEDI 211, or BIOC
301/302), or extensive experience in the field.
BIOC 539
Henry Levin
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Bioinformatics
Introduction to Genomics
David Kristensen
Jacqueline Major
John Malone
Aurelie Neveol
John Pepper
Pere Puigbo
Joseph Ryan
Kai Wang
Sijung Yun
_______________________________________
This course will introduce students to the Python programming language and to
general principles of computer programming. Topics will include fundamental
elements of programming such as variables, control structures, functions, and
data types; principles of good programming design and practice; introductions to
advanced topics such as algorithmic complexity, recursion, and object-oriented
programming; and the mechanics of using the Python interpreter interactively and
for executing programs. Many examples and exercises will be oriented toward
computational biology, but the course will aim to provide a firm foundation in
general programming.
Students must bring their own laptops to class and will be required to
install the Python interpreter on their laptops. This course is intended for
students with no prior computer programming experience.
Registration is limited to 15 students.
This course will introduce students to the Perl programming language and
to general principles of computer programming. Class exercises will focus
on using Perl to parse, analyze, and process large bioinformatics data sets,
especially FASTA sequence data and BLAST results, as well as .bed files
derived from RNAseq data. Topics will include fundamental elements of
programming such as variables, control structures, functions; elements of
the Perl programming language used for as regular expressions and reading
and writing to files; basic program design techniques; and the use of the
Perl debugger.
Students must bring their own laptops to class and will be required to
install the Perl interpreter on their laptops. This course is intended for
students with no prior computerprogramming experience.
Registration is limited to 15 students.
Tuesdays and Thursdays* in August, 2012 5:30-7:30
(*there will be no Thursday class on the last week)
Fall, 3 credits
Carlo Artieri
Ben Busby
John Malone*
The genome contains the blueprint from which cells, tissues, organs, and
organisms are built. Recently, advances in technology have allowed rapid
and cost-effective gathering of genomic sequences from cells, individuals,
populations, and different species. In a relatively short time, these advances have
birthed the field of genomics. While the building blocks of DNA consist of just 4
nucleotide types, the millions or even billions of nucleotides contained within a
genome make it a challenge to understand the complex information it contains.
This course provides a foundation for understanding the biology of the
genome. Topics covered will include DNA sequencing, genome analysis, the
structure and diversity of genome structure, evolutionary analysis of genome
biology, transcriptome and proteomic analysis, systems genomics, and the
relevance of genomics to medicine. Students will present research papers relevant
to weekly topics and conduct exercises that test concepts in genomics.
Registration is limited to 30 students.
BIOF 429
Practical Bioinformatics
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Computational Biology
Medha Bhagwat*
Ben Busby
Jacqueline Major
John Pepper
This two-part course will begin with an introduction to basic concepts of genomics and informatics as they may be applied in the clinic (first eight weeks
BIOF 502), and continue with an intensive treatment of data acquisition and
analysis relevant to most of these topics (final eight weeks BIOF 552).
Introductory sessions will provide a condensed review of the biological foundations
of bioinformatics and common resources in the field. Following that, topics
covered in the first half of the course will be epidemiology, population genomics
(with a focus on the 1000- and 100,000-genomes projects), genotype phenotype
relationships, evolution of cancer, toxico(pharmaco)genomics, immunogenomics,
bacterial and viral genomes, clinical decision support, and ethics of medical
genomics.
Registration is limited to 50 students.
BIOF 518
Theoretical and Applied Bioinformatics
BIOF 537
Spring, 3 credits
Ben Busby
Rezarta Islamaj
Yoo-ah Kim
Aurelie Neveol
Pere Puigbo*
Joseph Ryan
Sijung Yun
Colleen Bollin
Ben Busby*
Aaron Gussman
Yang Huang
Web based bioinformatic tools are useful for analysis of individual molecules
or very small datasets, but do not give researchers the accuracy and flexibility
of manipulating raw datasets required for study of biological systems. With this
in mind, we have designed a 16 week course where students will analyze large
biological datasets. Experimental design and biological project integration will be
a major theme of the course. After meeting with Dr. Busby to design an individual
biologically oriented
research project before the class begins, students will acquire and organize raw
datasets (shell scripting) and annotations into databases (mySql); output data
from databases as well as multiple web hits into files, and do higher order analysis
(such as tree building) with perl; followed by Bayesian, Boolean, and multifactorial
analysis of datasets using R, and use MATLAB as a way to describe/evaluate
trends originating from large datasets.
Prerequisites: This will be an intense and challenging course. Please take it
only if you have some basic experience with bioinformatics (or have taken Biol
518).
Students will be expected to have their own laptop computers preferably
pre-equipped with a way to run linux. If that is not possible, special
arrangements must be made with the instructors before the first class.
When registering for the course, please submit a non-governmental email
address to the registrar.
The objective of this course is to give students an introduction into the theory and
practice of a wide range of bioinformatic techniques and applications, enabling
them to use these tools in their own research. This course will be divided into
four modules: acquisition and analysis of sequence datasets, analysis of genomic
datasets from an evolutionary perspective, network analysis of genomic and
systems datasets (including natural language processing, and analysis and
prediction of protein structure. Three of the four sessions in each module will
be divided roughly 50 percent theoretical lecture and 50 percent learning to
use relevant computational tools. The final session of each module will be split
between a journal club, and commencement of work on a project assigned for
each module. By the end of the course, students should be able to acquire many
types of sequence data, identify similar genes, domains and motifs, identify gene
transfer events and alternative splicing, generate and analyze transcriptional and
gene expression networks, analyze proteomic data and make a prediction of
peptide structure from primary sequence.
Fall, 3 credits
Spring, 3 credits
Medha Bhagwat
Ben Busby
Aaron Gussman*
Kai Wang
This course will introduce students to a broad range of techniques and tools useful
for the design and management of innovative biological databases.
Introductory sessions will provide a condensed review of the biological foundations
of bioinformatics and common resources in the field. Subsequent classes will
cover a mix of technical issues as well as non-computational skills. Technical
issues will include hardware requirements, data capture using ontologies, and
database optimization and efficiency. Non-computational classes will cover
topics such as requirements analysis and user support. Later classes will
explore newer technologies in boinformatics, such as virtualization and cloud
computing, GIS, and non-relational databases. Students will explore the practical
application of these technologies to bioinformatics and computational biology.
Audience: The course is intended for students familiar with programming
and basic database design who would like to improve their understanding of
technologies useful for developing bioinformatics databases. Students will be
expected to participate in a class blog.
Prerequisites: Course participation is limited to students with previous
experience creating and using databases in a UNIX/LINUX environment, or by
instructor permission (completion of **Computational Biology 537** is also an
acceptable prerequisite). Students are expected to bring a laptop to class and to
install an Ubuntu Virtual Machine on said laptop.
Registration is limited to 25 students.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Bioinformatics continued
Medha Bhagwat*
Ben Busby
Jacqueline Major
John Pepper
This is the second half of the course (BIOF 502 first half) and will include a
hands-on treatment of GWAS, expression and proteomics, current mathematical
issues in epidemiology, comparative analysis of microbial and viral genomes, and
systems biology.
Audience: The first half of the course (BIOF 502) is intended for clinicians and
researchers interested in medical genomics. The second half of the course is
intended for students familiar with programming who would like to learn how to
query and analyze data from large medically relevant datasets. Students will be
expected to participate in class surveys, projects and journal article presentations.
Prerequisites: A basic understanding of genetics would be very helpful in the
first half of the course. For the second half of the course, participation is limited
to students with previous experience parsing large flat files, or by instructor
permission (completion of **Computational Biology 537** is also an acceptable
prerequisite). For the second part of the course, students are expected to
bring a laptop to class. Students taking the second half of the course will likely
benefit greatly from taking the first half, and therefore are required to take it,
except in exceptional circumstances, with permission of instructor.
Registration is limited to 20 students ( first half is BIOF 502).
BIOL 101
Miles Herkenham
Deborah Hinton
Susan Mackem
Anne Madeo
Maximillan Muenke
Yosuke Mukoyama
Constance T. Noguchi
Vicente Notario
Erik Read
Philip Wang
Matthew Wenham
Xuehua Xu
Carlos A. Zarate, Jr
Fall, 2 credits, Alternate Years, 2012
IIntroductory Biology
Vicente Notario
In
Introductory Biology will be conducted at the level of a first year college course. It
is intended to provide a broad understanding of biological principles sufficient to
pprepare the beginning student for more advanced courses in biology and molecular
bbiology. The focus of the course emphasizes molecular and classical biology.
BIOL 102
Spring, 2 credits
I
Introductory
Molecular
Biology-Genetics
B
Ruth Chia
Fanette Fontaine
Erik Read*
BIOL 262
M
Molecular
Approaches
tto Studying Diseases
Philip Wang
This
lecture discussion based course is designed to help students gain an
T
appreciation
of techniques including molecular, cellular, biochemical, transgenic
a
animal
models, and imaging techniques. Students will learn a historical perspective
a
of
o technique development, discuss applications and explore recent advances
using
these specific approaches. Diseases that will be addressed include both
u
monogenic
and polygenic diseases of complex origin.
m
Prerequisites: Undergraduate Biology and Chemistry.
10
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
BIOL 317
Molecular and Cell Biology
Fall, 2 credits
Mawadda Al-Naeeli
Lijin Dong
Michael G. Espey*
Matt Wenham
Xuehua Xu
This course offers a broad overview of cell biology, exploring the molecular basis
of cellular structure and function. Sample topics include cellular metabolism,
organelle structure and function, gene expression, cell signaling, and the cell
cycle. The course will also address experimental approaches to studying cell
biology and the pathological consequences of abnormal cellular function.
Textbook content will be supplemented with recent literature.
There is a suggested prerequisite of biology 101 or one semester of
college-level biology.
BIOL 319
This course introduces students to stem cells and their associated niches. Topics
include types of stem cell niches and signaling pathways used. The different
types of stem cells covered will include embryonic, hematopoietic, mesenchymal,
germline, epidermal and neural stem cells. This course will cover techniques used
to study stem cells in the laboratory, applications of stem cells and potential for
the treatment of diseases.
Fall, 3 credits
Miles Herkenham
This course will review the major structures and neuronal pathways of the human
brain starting with those found in the spinal cord and moving to medulla, pons,
cerebellum, midbrain, hypothalamus and thalamus, and finishing with the limbic
system, basal ganglia, hippocampus and cerebral cortex. Brain development will
be used as an aid in appreciation of structures and connectivity. A functional
neuroanatomical description will be given to sensory (somatic and autonomic),
motor, association, extrapyramidal, and limbic systems. Some consideration
will be given to the relationship between cortical areas defined on the basis
of cytoarchitectonics and areas of the human brain as parceled out by brain
imaging techniques. The major differences in the anatomy of brains of humans
as compared to other species more commonly used in research settings will be
covered. The goal of this course is to educate those doing animal and human
brain research who want to become familiar with basic neuroanatomy.
Prerequisite: BIOL 101 or equivalent.
Robert S. Adelstein*
Susan Mackem
Yosuke Mukoyama
Constance T. Noguchi
This course will survey the fundamentals as well as recent progress in vertebrate
development including stem cell biology. The first half of each class will consist
of a lecture based on a relevant chapter in the latest edition of Scott Gilberts
textbook, Developmental Biology. The second half of each class will be devoted to
presentation and discussion of important articles from the current literature, based
on the lecture. The emphasis will be on the mechanisms underlying vertebrate
development.
Course objective: After attending this course, the participant should be able to
discuss the developmental processes that can be affected by genetic mutations
giving rise to genetic diseases.
Prerequisite: Biology 101 or college level biology.
BIOL 338
BIOL 325
BIOL 327
Claudia Gebert
Aberrant regulation of the epigenome has been associated with the onset of many
human diseases including development disorders and cancer. The objective of
this course are to give students an overview of the most common epigenetic
mechanisms known to date and how, if gone awry, they relate to the pathogenesis
of a particular disease. Each class will focus on a human medical disorder and
discuss the epigenetic mechanisms involved in the pathogenesis of this disorder
as well as diagnostic tools and available treatment options. By the end of the
course, students can expect to have a basic understanding of DNA methylation,
histone modifications, genomic imprinting, and X chromosome inactivation, and
disorders associated with aberrations in epigenetic regulatory mechanisms.
Prerequisites: Prior particular knowledge on epigenetics is not required to
attend this course, however, introductory biology knowledge is desired.
Registration is limited to 25 students.
BIOL 435
Current Trends in the
Neurobiology of Mental Illness
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
11
BIOL 504
Developmental and
Synaptic Neuroplasticity
Andres Buonanno*
Monique Dubois-Dalcq
GENE 415
Sankar Adhya*
Deborah Hinton
This course examines the ways in which cells regulate gene expression using
model systems, including E.coli and bacteriophages. The course emphasizes
the genetic and biochemical approaches that are used to study regulation.
Mechanisms of transcriptional, translational, and post-translational control will be
included, and comparisons made between mechanisms used in prokaryotes and
eukaryotes. The interaction of regulatory mechanisms into complex regulatory
circuits will be discussed, using both classic examples and selected topics from
the latest lectures.
Prerequisites: Microbial genetics and biochemistry.
GENE 500
Suzanne Hart*
Maximillian Muenke
GENE 505
Leslie G. Biesecker
12
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
GENE 510
GENE 644
Tuition: $580
Class will meet Wednesdays 5:30pm-7:30pm
GENE 514
Current Concepts in Clinical Molecular
Genetics and Molecular Diagnostics
Spring, 1 credit
BIOC 539
Recent Discoveries in
Molecular Biology
(See page 7)
BIOF 312
Introduction to Perl
(See page 8)
BIOF 411
Introduction to Genomics
(See page 8)
Suzanne Hart
Tuition: $145.00
Class will meet Thursdays 5:30pm-6:30pm
The objective of this course is to provide a review of molecular diagnosis of
common hereditary or neoplastic disorders for which DNA based diagnosis is now
in routine use. Topics include FGFR3 disorders, fetal blood typing, thrombophilias,
hemochromatosis, fragile X syndrome, polyglutamine disorders, hereditary breast
cancers, Charcot Marie Tooth and spinal muscular atrophy, PraderWilli and
Angelman syndromes, mitochondrial diseases, Duchenne and Becker muscular
dystrophy, cystic fibrosis, and Smith-Lemli-Opitz Syndrome. There will also be
sessions on genetic risk prediction using linkage and Bayesian analysis as well
as a class on DNA forensics and paternity testing. The course is designed as part
of the required curriculum for Clinical Genetics residents and fellows preparing for
the Clinical Molecular Genetics boards given by the American Board of Medical
Genetics.
Prerequisite: GENE 500 and permission of the instructor.
The objective of this course is to provide a review for candidates for the American
Board of Medical Genetics Subspecialty examinations (clinical genetics, molecular
genetics, biochemical genetics, cytogenetics, and genetic counseling). Topics
to be covered include statistical and mathematical subjects in clinical genetics
and population genetics, clinical cytogenetics, dysmorphology, ophthalmologic
genetics, and general treatment and management of genetic diseases.
BIOF 429
Practical Bioinformatics
(See page 8)
BIOF 502
Medical Genomics for
Clinicians and Researchers
(See page 9)
BIOF 518
Theoretical and Applied Bioinformatics
(See page 9)
BIOF 537
Computational Biology
(See page 9)
BIOF 538
Biology Databases Design
(See page 9)
BIOF 552
Medical Genomics for Clinicians and Researchers
(See page 10)
STAT 435
Genetic Epidemiology
(See page 34)
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
13
Biotechnology (BIO-TRAC)
R/M Nardone Associates, Inc. 301-496-8290
(Course Content) www.biotrac.com
nardonem@mail.nih.gov
301-496-2316
14
Biotechnology Techniques
FAES
(Registration Information)
TRAC 1
TRAC 2
TRAC 3
Recombinant DNA Methodology II
This workshop is only available on a contract basis only.
Contact Mark Nardone at nardonem@mail.nih.gov for further information.
This lecture and laboratory course complements TRAC 2 and is intended for
those who are familiar with basic methods of recombinant DNA using plasmids
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
and prokaryotic cells. This course will build on that information and focus on the
use of eukaryotic recombinant DNA systems including newer vectors, selected
host systems, and specialized techniques and applications which stem from
opportunities created by recombinant DNA.
Topics: Construction of cDNA Libraries in Lambda Phage Vectors; Special
Vectors and Hybrid Vectors; Synthesis of Gene Probes; Yeast: Cloning Systems
and Host of Foreign DNA; Transient and Stable Expression of Recombinant DNA
in Mammalian Cells; Viral Expression Vectors; Baculovirus System for Protein
Synthesis; PCR - Methods and Applications; Eukaryotic Gene Expression:
Analysis of Control Mechanisms; Nucleic Acid Probe Technology; Mapping
and Characterization of Complex Genomes; Nucleic Acid Cycle Sequencing;
Applications of Antisense DNA; Current and Future Applications of Recombinant
DNA; Screening of Phage Using Oligonucleotide Probes; In Vitro Mutagenesis;
Transient Transfection Assays; Two-Hybrid System to Identify Protein Interaction In
Vivo; Microarray Construction and Use; Proteomics.
Registration limited to 28 students.
TRAC 4
TRAC 5
Separation Techniques
This workshop is only available on a contract basis only.
Contact Mark Nardone at nardonem@mail.nih.gov for further information.
This lecture and laboratory course is designed to provide theoretical and practical
knowledge of current methods of separation and detection of the components in
biological samples.
Lecture and Laboratory Topics Include: Separation Strategies; Ion
Exchange and Gel Permeation Chromatography; Affinity Chromatography and
Chromatofocusing; Denaturing and Non-Denaturing Gel Electrophoresis; Agarose
Gel Electrophoresis; Pulse Field Gel Electrophoresis; PAGE; Separation and
Purification Strategies; Analytical and Preparative Centrifugation; Protein and
Nucleic Acid Detection and Determination; Immunoblotting and ELISA Procedures;
Medium and High Pressure Liquid Chromatography (HPLC) of Proteins and
TRAC 6
Cellular and Molecular Basis for the
Understanding, Diagnosis and
Therapy of Cancer
This workshop is only available on a contract basis only.
Contact Mark Nardone at nardonem@mail.nih.gov for further information.
The objective of this lecture/lab course is to present an integrated view of cancer
studies at the cellular and molecular level with human cancer diagnosis and
therapy in a clinical setting.
Lecture and Laboratory Topics Include: Human Carcinogenesis: An overview
of Symptomology, Pathological Sequalae, Diagnosis, and Therapeutic Strategies;
Genetic and Epigenetic Events in Carcinogenesis; Cell Transformation:
Cytogenetic, Behavioral, Oncogene and Tumor Suppressor Gene Changes;
Protooncogenes, Oncogenes, Signal Transduction and Cell Cycle Regulation;
Non-Random Chromosome Aberrations and Cancer; Use of in Situ Hybridization
with Tissue Sections and Chromosome Preparations for Diagnosis; Model
Systems for the Study of Receptors and Cancer: Interleukin2, Colony Stimulating
Factor, and Epidermal Growth Receptors; Molecular Genetic Analysis of Breast
and Colorectal Cancer; Apoptosis and Prostate Cancer; Angiogenesis and
Metastasis; Application of Microarray and siRNA Technologies; Cancer Cell
Markers and Screening.
Registration limited to 28 students.
TRAC 7
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
15
TRAC 8
TRAC 9
Polymerase Chain Reaction and
Molecular Hybridization Technology
TRAC 10
TRAC 11
Genome Analysis
This lecture and laboratory course will focus on two important technologies which
share strong interfaces with basic molecular biology research, genetics, molecular
pathology (including cancer and genetic diseases), and identification of viral,
bacterial and protozoan pathogens, namely the polymerase chain reaction and
molecular hybridization technology.
TBA
Lecture and Laboratory Topics Include: The Polymerase Chain Reaction Topics
include PCR and its Optimization, Thermostable DNA Polymerases; Amplification
of Genomic DNA and cDNA; Use for RNA Amplification and mRNA Quantitation;
Probes and Primers: Primer Design; Synthesis and Labeling; Research
Applications: Recombinant PCR, Cloning, Sequencing, DNA Polymorphisms,
Screening of Libraries; Clinical and Forensic Applications; Sample Preparation;
Detection of Viruses and Bacteria; Oncogenes and Cancer; Familial Relationships;
in situ PCR and PRINS; Contamination Control.
The Molecular Hybridization Topics include Probe Design, Optimization, and
Application at the Chemical and Cytological Levels; Principles of Hybridization;
Base Structure, Modification, Stability and Specificity; Tm and Cot1/2; Preparation
16
TRAC 12
Transgenic Technology:
Methods and Applications
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
The objective of this course is to provide the student with a good theoretical
background as well as practical information and laboratory experience in the
design, expression, detection and purification of recombinant proteins from a
variety of expression systems.
Lecture and Laboratory Topics Include: Introduction to Protein Purification
Techniques; Expression of Proteins in Prokaryotic and Eukaryotic Cells;
Requirements, Advantages and Disadvantages; Prokaryotic Expression Systems;
Strains, Tags and Purification Systems; Expression in Insect Cells: Baculovirus and
Drosophila Systems; Expression in Mammalian Cells: Detection and Purification
(Immunohistochemistry, Reporter Gene Assays, GFP, Tags for Expression/
Purification Systems); Generation of Antibodies to Recombinant Proteins: System
Considerations and Antibody Purification; Expression in Yeast Cells (Pichia).
Registration limited to 24 students.
TRAC 18
Stem Cells
TRAC 15
The emergence of stem cells as important tools for biomedical research prompts
this offering of a 5 day, lecture-lab training course on stem cells.
The lectures will cover the importance, origin, and fate of diverse stem cells
(hematopoietic, muscle, nerve, skin and embryonal) and the factors that control
their differentiation. Special emphasis will be on isolation, identification, culture,
and use of stem cells and their progeny.
TRAC 16
Lecture and Laboratory Topics Include: Bone Marrow Stem Cell Plasticity;
Hematopoietic Stem Cells; Cell Lines as Models of Stem Cells; Flow Cytometry
and Stem Cell Isolation and Characterization; Murine embryonic Stem Cells;
Mesenchymal Stem Cells; Differentiation of Stem Cells into Bone; Isolation of
Cells from Bone Marrow Collection; Histology Marrow vs. Peripheral Blood; Liver
Stem Cells; Stem Cells in CNS; Differentiation of Hemotopoietic Cells; Stem Cell
Transplantation: Re-engineering the Immune System; Regulatory Perspective
Regarding Stem Cells and Gene Therapy.
Registration limited to 28 students.
TRAC 19
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
17
TRAC 20
Immunocytochemistry
TRAC 23
Flow Cytometry:
Principles and Methods
TRAC 21
TRAC 24
TRAC 22
Hybridization Techniques:
18
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
TRAC 25
Cycle; Primer Design and Usage including Tools for Primer Design; Thermostable
DNA Polymerases; Optimization; PCR Additives; Contamination Control; Reverse
Transcription PCR (RT-PCR); PCR Mutagenesis; Cycle Sequencing; Long
Range PCR; 5- and 3-RACE PCR; Clinical and Forensic Applications; Practical
Modifications to PCR.
Registration limited to 28 students.
TRAC 28
TRAC 29
TRAC 26
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
19
TRAC 32
Nanotechnology in Medicine
TRAC 31
TRAC 30
Nanotechnology has exploded onto the scientific scene in the last few years and has
impacted nearly every area of scientific research. The infancy of nanotechnology
began in materials science laboratories. The field of nanotechnology has matured
and is now at the forefront of medical research. Nanomedicine has been heralded
as the next big thing. Popular literature promises tiny machines that will have
a huge impact on disease and aging. The reality is that nanomedicine can be
divided into three basic categories: tiny machines, diagnostics, and therapeutic
delivery. This course will discuss all of these nanotechnology applications and
focus on preparation and use of different nanotechnologies.
Next generation nanomedicine technologies are being developed to provide
continuous and linked molecular diagnostics and therapeutics. Research is being
performed to develop nano-engineered systems which will seek out diseased
(e.g. cancerous) cells, enter those living cells, and either perform repairs or
induce those cells to die through apoptosis. These nanomedicine systems
are being constructed to be autonomous, much like present-day vaccines,
but will have sophisticated targeting, sensing, and feedback control systems
superior to conventional antibody-based therapies. The fundamental concept of
nanomedicine is not to just kill all aberrant cells by surgery, radiation therapy, or
chemotherapy. Rather it is to fix cells, when appropriate, one cell-at-a time, to
preserve and re-build organ systems. This technology is currently being developed
to treat diseases such as cancer, retinopathy of prematurity, and diabetes.
In this three-day training program, participants will learn the history of
nanotechnology in medicine through reading and discussing the primary
literature. Participants will learn about the preparation and clinical use of
different nanotechnologies. In laboratory sessions, participants will prepare
and characterize two such systems. These techniques will then be used to in a
bioassay to deliver material to cells in vitro. Lecture and detailed instructions to
generate and characterize nanoparticles for diagnostics and therapeutic delivery
will also be included.
Topics: Introduction to nanotechnology in cancer; Dendrimer MRI contrast agents:
synthesis and application; Nanomaterial characterization: Light scattering and
EM; Synthesis and application of liposomes for drug delivery; Silica nanotubes
for drug delivery; Application of nanotechnology for clinical diagnosis; Analysis of
nanomaterial interaction with biological systems; PEGylated colloidal gold-TNF
nanomedicine - from manufacturing to pre-clinical assessment.
Registration limited to 28 students.
Topics: Overview of the immune system and the induction of an immune response
highlighting crucial factors for vaccinology; protein and peptide vaccines, viral
vaccines (pox and avipox viruses; adenoviruses), bacterial vaccines; Cutting edge
vaccines such as DNA vaccines, pulsed dendritic cells, nanoparticles; Purpose of
adjuvants, classes of adjuvants with in depth discussion of adjuvants used in the
20
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
TRAC 33
TRAC 34
TRAC 36
(28 hours of lecture and laboratory training)
Immunofluorescence and
Confocal Microscopy
TRAC 35
21
$795.00 (1 credit)
PCR;
PCR;
using
PCR;
TRAC 38
TRAC 39
Epigenetics
TRAC 40
Protein Informatics
22
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
TRAC 41
TRAC 42
TRAC 43
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
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CHEM 212
Organic Chemistry II
For students wishing to take a complete program in chemistry without prior studies
in this field, the following sequence is recommended, at the rate of one course per
semester:
CHEM 101
General Chemistry I
General Chemistry II
Marc Nyden
Fall, 3 credits
Belhu Metaferia
Spring, 3 credits
Belhu Metaferia
Organic Chemistry I
This is a continuation of CHEM 211. This semester will cover alcohols, esters,
carboxylic acids, amides, ethers, amines, aldehydes, and ketones with a brief
overview of some biologically relevant structures such as carbohydrates, amino
acids, DNA, RNA and lipids.
CHEM 220
This course is a continuation of CHEM 101 and will cover the following topics:
Chemical equilibrum, pH, Reaction kinetics, Redox reactions, Solubility, an
introduction to organic and biochemistry. As in CHEM 101, we will emphasize a
conceptual understanding and show how the chemistry learned here can apply to
health related situations. The course will be taught at a chemistry major level, and
will provide the background for organic chemistry, biochemistry and other health
sciences where chemistry is utilized.
CHEM 211
Darn I. Freedberg
This course is an introduction to Chemistry and will cover the following topics:
properties of matter, units of measurement, elements, compounds, mixtures,
conservation of mass, symbols and formulae, stoichiometry and balancing
chemical reactions, the periodic table, electronic structure, covalent bonding,
molecular structure, acid base reactions, gas laws, states of matter and solution
properties. We will emphasize a conceptual understanding and show how the
chemistry learned here can apply to health related situations. The course will be
taught at a chemistry major level, and will provide the background for organic
chemistry, biochemistry and other health sciences where chemistry is utilized.
CHEM 102
Spring, 3 credits
CHEM 220A: In the first semester of this course we will focus on the principles
of thermodynamics and their basis in kinetic theory and statistical mechanics.
The major topics will be the first and second laws of thermodynamics, chemical
and phase equilibria, solutions, transport properties and the rates of chemical
reactions. These topics will be applied to problems of biological interest including
protein structure and binding and enzyme kinetics.
CHEM 220B: In the second semester of this course we will cover the theory of
quantum mechanics and its application to chemistry. This will include an overview
of spectroscopy (IR, UV-VIS, NMR) and X-ray diffraction methods. An exposition
of modern computational techniques, which are used to study the conformations
and dynamics of biological molecules will also be presented.
Prerequisites: General chemistry and physics.
CHEM 244
Practical NMR Spectroscopy:
Basic Methods for Characterizing
Molecules
Fall, 3 credits
Darn Freedberg
The goal of the course is to introduce and flesh out the concepts already familiar
to students who may have studied them in Organic Chemistry. This course will
focus on the use and application of basic NMR concepts and methods. We will
cover chemical shifts, couplings, data acquisition, dynamic NMR, one-and-two
dimensional NMR and NOE with a practical and generally non-mathematical
focus. These will then be applied to solving problems and choosing the best
techniques for different types of molecules.
Prerequisite: One year of Organic Chemistry
Fall, 3 credits
Darn I. Freedberg
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FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
CHEM 327
Spring, 2 credits
CHEM 341
Advances in Synthetic
Organic Chemistry I
Daniel Appella
IMAG 409
Fall, 2 credits
Michal Komlosh
PHYS 201
Introductory Physics I
Fall, 3 credits
Warren J. Eresian
This first part of a two semester course in general physics will cover topics in
kinematics, mechanics, work and energy, fluids, vibrations and waves, and sound.
Together with PHYS 202, this may satisfy the minimum requirement of medical and
dental schools. Knowledge of trigonometry and elementary calculus is required.
This course has no laboratory.
The first semester of this two semester review of new developments in synthetic
organic chemistry will deal with carbanion chemistry, ylids, chemistry of organo
boranes, organo cuprates, organo palladium and other organo metallics, including
Grubbs olefin metathesis. Diasterioselective and enantioselective reactions,
particularly as applied to complex syntheses, will be stressed. Methods and
examples will be taken from the recent literature.
Prerequisite: One year of organic chemistry
PHYS 202
Introductory Physics II
Spring, 3 credits
Warren J.Eresian
CHEM 342
Advances in Synthetic
Organic Chemistry II
Daniel Appella
PHYS 245
Topics in Modern Physics Relativity,
Quantum Mechanics and Cosmology
Warren J. Eresian
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
25
completed the requirements for taking the MCAT and have questions about this
course please contact the instructor. This course extends beyond a review of
general knowledge of biology, chemistry, and physics. It also reviews problem
solving, critical thinking, writing skills, and knowledge of science concepts and
principles prerequisite to the study of medicine.
Jos Cceres
Jeff Chyatte
Suzanne Epstein
Jessica Krash
Reza Momenan
Patrick ODonnell
Oliver Ou
Ralitza Patheva
Katherine B. Szarama
GENL 161
The course provides you with rigorous coursework and extracurricular reading to
expand your vocabulary, develop your reading pace, and increase your familiarity
with texts and arguments in various disciplines. It enables you to spend time
devoted to reviewing the relevant material.
Art Songs:
Chamber Music with Words
Lecture with LIVE performances
Jos Cceres
Suzanne Epstein
Jessica Krash
Patrick O Donnell
Ralitza Patcheva
This course will explore art songs as chamber music for voice and piano, covering
European and American repertoire from the classical period to the 20th century.
In each session, the songs will be performed live in the original languages, both
as examples during the lecture and as an uninterrupted performance following the
lecture. Lectures will discuss the lives and times of the composers and poets, as
well as features of the particular songs. Listeners will learn to hear and appreciate
the interplay between voice and piano, differences between musical styles, and
the relationship between the music and text. These lectures are intended for music
lovers of all kinds, whether they have formal music training, a little background, or
none at all.
Limited opportunities for registered students to perform in class may be available
by special arrangement. Singers and pianists who wish to perform in class should
contact Jessica Krash.
GENL 163
Qi Guang and Tai Chi with
a Brief Review of Chinese Martial Arts
Fall, 1 credit
Reza Momenan
The course has 14 units. One unit will be covered each week. Each unit covers
a portion of Physical Sciences, Verbal Reasoning and Biological Science sections
of the exam. This is a systematic review, going through all aspects of each unit in
an organized way using an online power point slide format. Students are expected
to participate. Extensive homework will be presented in the online, multiple choice
format of the MCAT and is suitable for class, group, and individual instruction.
Students will be expected to bring a hard copy of online power point slides and
online homework to each class. They are expected to identify topics that are
unfamiliar, and use their graduate textbooks and notes where available. A study
partner may be chosen. Scores are reported in Verbal Reasoning, Physical
Sciences, Writing Sample, and Biological Sciences.
Registration is limited to 15 students. No students will be admitted after the
first day of class.
GENL 322
GRE-Review
This review course will prepare students for the Graduate Record Examinations
(GRE) General Test. We will cover the Quantitative, Verbal, and Analytical Writing
portions of the General Test with a primary focus on test content. Brief discussions
of test-taking strategies will also be included. Students will have access to a
variety of math, verbal and analytical writing practice material. The lectures will be
interactive, with student participation strongly encouraged.
Registration is limited to 15 students.
GENL 511
Boot Camp for University Teaching
A brief review of the origin and history of classical martial arts in the world, with
particular focus on Chinese Martial Arts is presented in this course. Through a
series of theoretical and practical sessions, the principles of what are referred
to as internal and external martial arts are briefly reviewed. In this course,
various aspects of cultivating internal energy (Qi-pronounced Chi) through static
and dynamic meditations are discussed and practiced. Scientific evidence and
research on physiological effects of these exercises are also discussed. Several
sessions will be devoted to training various self-defense techniques. Physics and
mechanics of external martial arts are also exercised. This course will include
30% theory and 70% practical workshop. No prior experience is required.
Oliver Ou*
Katherine B. Szarama
GENL 319
MCAT Review
This is a review course that prepares students for the Medical College Admission
Test (MCAT) given by the American Medical College Application Service. For
a description of who should take the MCAT and whether or not you meet the
requirements for taking the MCAT, please visit www.aamc.org. If you have not
26
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
IMMU 521
Molecular and Cellular Mechanisms
of Immunity I
IMMU 403
Fall, 2 credits
John F. Finerty
B. J. Fowlkes
Pierre Henkart*
IMMU 522
Spring, 2 credits
IMMU 419
Fall, 2 credits
Vaccines 2012
Ira Berkower
Howard Streicher*
In the 200 years since Edward Jenner introduced vaccination to replace the older
less effective practice of variolation, vaccines have become the bargain basement
of medicine: cheap, safe, and effective. This course is designed to provide detailed
survey of modern vaccinology, beginning with an examination of the traditional
vaccines. The course will identify the factors that distinguish successful from failed
vaccines, integrating coverage of molecular and immunobiology with clinical and
public health questions and provide a detailed structure for understanding how
innovative vaccines are developed. This course will cover vaccine approaches to
infectious disease, cancer vaccines, and HIV and selected topics of current interest.
Knowledge of basic immunology or consent of the instructor is recommended.
IMMU 504
Allergy and Clinical Immunology
The objective of this course is to correlate basic immunopathologic mechanisms
and human disease states. The major emphasis will be on the understanding of
mechanisms by which immunologic effector systems prevent or produce clinical
disease. Each lecturer will focus on the immunologic events involved in selected
organs, diseases or types of immune responses. The course is designed to bridge
the gap between immunologic principles and the maintenance of human health
or disease states. It is aimed principally at students with graduate degrees in the
medical sciences (M.D., Ph.D., D.D.S, R.N.) although students with extensive
experience in immunology may find the medical applications rewarding. Students
Scott Durum*
Joshua Farber
MICR 211
Introductory and General Microbiology
Fall, 3 credits
Jane Tang
This course provides an overview of the microbial world the largest biodiversity
on earth. Identification and characterization of microorganisms will be discussed,
as well as their cellular structures, physiology and genetics. Also included are
topics in emerging diseases; infectious agents affecting humans, animals and
plants; bioterrorism, microbial ecosystems; and biotechnological applications such
as food production and bioremediation.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
27
Fall, 2 credits
Suresh K. Arya
This course provides an introduction to the molecular virology of virus infection and
progeny virus production and spread. It details molecular mechanisms of virus
entry, replication, transcription, translation, and propagation in the host. Starting
with the molecular structure of select viruses, the course will focus on strategies
used by various viruses for successful infection and propagation, including
molecular mechanism of host defense and its evasion by the viruses. Select
viruses important to human health (e.g., influenza virus, papillomavirus, HIV), will
be considered in some details, highlighting recent advances in the understanding
their biology and pathogenesis. The lectures will include discussion of current
strategies for vaccine development and viruses as vectors for gene transfer in
functional genomics and gene therapy.
MICR 418
Emerging Infectious Diseases
Spring, 3 credits
Robert H. Hall
Suresh K. Arya
This course will begin with the description of the diseases that turned out to be
caused by viruses, such as cancer and AIDS, from antiquity to the present. This
will lead into (the methods) of discovery of viruses, their general properties, mode
of infection and propagations, genetics and evolution, viral pathogenesis, and host
defense. This will be followed by consideration of the select viruses and diseases
they cause in organ systems, such as respiratory tract, nervous system, bloodborn infections, sexually transmitted infections.
MICR 527
Spring, 2 credits
HIV/AIDS remains one of the greatest research and public health challenges
facing our nation and the world. This three credit course is designed to provide
a complete overview of the spectrum of AIDS research being performed today.
Examples of topics to be covered by guest lecturers include: epidemiology,
social and behavioral science, virology and biochemistry of HIV; how HIV causes
disease; the current snapshot of the global epidemic; the discovery, development,
and evaluation of anti-HIV drugs and vaccines; and the design and implementation
of methods to prevent the spread of HIV. We will also examine the current scientific
and ethical issues facing AIDS research.
28
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Languages
Clark Lum, Chairperson
Anamaria Banu
Nancy Jorgenson
Donna King
Maria Suarez Lissi
Clark K. L. Lum
CHIN 402
Chinese Literature II
CHIN 101
Introduction to Chinese
Fall, 3 credits
Clark K. L. Lum
Intermediate Chinese
Clark K. L. Lum
CHIN 102
Spring, 3 credits
Spring, 3 credits
Clark K. L. Lum
ENGL 105
Fundamental English Conversation I
Fall, 3 credits
Fran Miller
This course is designed for those who have studied a large amount of English
grammar and vocabulary, but whose ability to understand and speak English is
limited. Emphasis on listening to natural American English and basic techniques of
modern conversation. Prepared and spontaneous oral presentations are required.
Discussion of American culture and customs.
Registration limited to 10 students
ENGL 108
CHIN 301
Fall, 3 credits
Practical Chinese
Clark K. L. Lum
Practical Chinese
ENGL 205
Intermediate English I
Clark K. L. Lum
Fall, 3 credits
Nancy Jorgenson
Chinese Literature I
Spring, 3 credits
CHIN 401
Fran Miller
CHIN 302
Spring, 3 credits
Fall, 3 credits
Clark K. L. Lum
ENGL 207
Intermediate English II
Spring, 3 credits
Nancy Jorgenson
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
29
Languages continued
ENGL 302
Advanced English Conversation I
Fall, 3 credits
Fran Miller
Spring, 3 credits
Fran Miller
ENGL 305
Advanced English Structure I
Fall, 3 credits
Fran Miller
Advanced grammatical forms and structures are taught. Usage and variety of
tenses, modals expressing degrees of necessity and certainty, other auxiliaries,
nouns, noun modification, quantifiers, adjective clauses and phrases are studied
thoroughly on the advanced level.
Donna King
FRCH 201
Intermediate French I
Fall, 3 credits
Anamaria Banu
This course will help students develop a more fluent communication in French
through a thorough review and interactive practice of French language structures.
Reading and writing assignments held students develop analytical and critical
thinking skills. Internet and computer aided activities, as well as audio and video
assignments provide students with cultural knowledge and ensure continued
development of functional communication in French in the four skill areas: reading,
writing, listening, and speaking.
(Text: Controverses, L. Oukada, D. Bertrand, J.L. Solberg; Heinle 2011)
(Controverses Student Activities Manual)
Prerequisite: One year of French at university level or two years of high school
ITAL 101
Italian for Beginners I
Fall, 3 credits
Illie Tecuta
ENGL 306
Spring, 3 credits
ENGL 304
FRCH 102
This course is a continuation of ENGL 305. Passive voice, adverb clauses and
phrases, noun clauses, direct and indirect speech, conditionals and subjunctive
are studied thoroughly on the advanced level.
ITAL 102
Italian for Beginners II
Spring, 3 credits
Illie Tecuta
FRCH 101
French for Beginners I
Fall, 3 credits
Donna King
30
JAPN 101
Fall, 3 credits
Introduction to Japanese I
Yuki Moorman
An Introductory course in Japanese language and culture. Focus on the useful
oral communication, basic grammatical structure, and the Japanese writing
system are introduced. Use emails and chat sites for reading, writing and
listening exercise along with conventional textbook. Section of anime and movies
are used for conversation practice and cultural understanding.
Failure to re-register for the second semester could result in cancellation
of that semester due to low enrollment.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
JAPN 102
Introduction to Japanese II
Spring, 3 credits
Yuki Moorman
JAPN 203
Intermediate Japanese I
Continued study of basic sentence patterns and their use in oral communication
and simple writing. Reading comprehension and vocabulary building are also
emphasized. 80 basic Kanji are introduced.
Prerequisite: JAPN 102 or equivalent.
Failure to re-register for the second semester could result in cancellation
of that semester due to low enrollment.
JAPN 204
Intermediate Japanese II
Continuation of JAPN 203.
Prerequisite: JAPN 203 or equivalent.
Failure to re-register for the second semester could result in cancellation
of that semester due to low enrollment.
JAPN 407
Advanced Japanese III
Vocabulary expansion, reading comprehension, and discussion of cultural and
cross-cultural topics. This course is conducted in Japanese.
Prerequisite: JAPN 306 or equivalent.
Failure to re-register for the second semester could result in cancellation
of that semester due to low enrollment.
JAPN 408
Advanced Japanese IV
Continuation of JAPN 407.
Prerequisite: JAPN 407 or equivalent.
Failure to re-register for the second semester could result in cancellation
of that semester due to low enrollment.
SPAN 101
Spanish for Beginners I
Fall, 3 credits
Angela Rodriguez
JAPN 305
Advanced Japanese I
Intermediate to advanced grammar, vocabulary expansion and reading
comprehension. Discussion of cultural and cross-cultural topics.
Prerequisite: JAPN 204 or equivalent.
Failure to re-register for the second semester could result in cancellation
of that semester due to low enrollment.
JAPN 306
Advanced Japanese II
Continuation of JAPN 305.
Prerequisite: JAPN 305 or equivalent.
Failure to re-register for the second semester could result in cancellation
of that semester due to low enrollment.
SPAN 102
Spanish for Beginners II
Spring, 3 credits
Angela Rodriguez
SPAN 203
Intermediate Spanish I
Fall, 3 credits
Juana Roman Maquiera
31
Languages continued
SPAN 204
Intermediate Spanish II
Spring, 3 credits
Juana Roman Maquiera
SPAN 208
Spanish for Health Care Providers
Spring, 3 credits
Maria Suarez Lissi
32
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
STAT 317
Introduction to Epidemiology
Kushang V. Patel
Yves Rosenberg
Deven Shah
Fatma Shebl
Sue-Jane Wang
MATH 127
Elementary Calculus I
Fall, 3 credits
Reza Momenan
This course is an introduction to calculus and is aimed at students who have not
taken calculus in their previous education. The course will begin with a review of
precalculus topics including graphing, functions and algebra which are then used
as the groundwork for exploring the core topics of limits, continuity, differentiation
and integration. Where possible, problems considered in class will be of a
biological nature and problem sets will be available to promote understanding.
Together with MATH 128, this course may satisfy the minimum requirement of
medical and dental schools.
Required textbook: Calculus for Biology and Medicine, 2nd edition, Claudia
Neuhauser
Prerequisites: Knowledge of trigonometry, basic algebra and graphing are
required
MATH 128
Elementary Calculus II
Spring, 3 credits
Reza Momenan
STAT 200
Introduction to
Experimental Statistics
Fall, 3 credits
Kushang G. Patel
STAT 318
H. M. James Hung*
Sue-Jane Wang
The objective of this course is to learn more about the statistical methods used
in epidemiologic research. Particular emphasis is given to the analysis of data
derived from case-control and cohort studies. Procedures for adjusting for effect
modifiers and confounding factors, in log linear models and life table methods are
discussed.
STAT 321
Methodology in Clinical Trials
Fall, 3 credits
Yves Rosenberg
The objective of this course is to learn the concepts and methodology used in the
design and conduct of randomized clinical trials. Topics to be covered will include
a description of the main types of trial designs, principles of randomization and
stratification, issues in protocol development (defining objectives and endpoints,
blinding, choice of control), recruitment and retention, data collection and quality
control issues, monitoring, and analyses of trials reports. Textbook material will
be supplemented frequently by material from the literature. Guest lecturers will
give lectures on power and sample size calculations, life table analysis, quality
of life and cost evaluation. Examples from the cardiovascular, pulmonary and
cancer areas will be used when appropriate. The course is intended for biomedical
researchers desiring exposure to the clinical trial area.
Prerequisite: STAT 500 or equivalent, or consent of the instructor.
STAT 322
Intermediate Epidemiology
Spring, 3 credits
Fatma Shebl
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
33
New
STAT 435
Fall, 3 credits
Genetic Epidemiology
Jacqueline Major
This course surveys the epidemiological approaches used to uncover genetic risk
factors for common diseases. Students should completed introductory courses
in epidemiology and biostatistics. No genetics is required, but background
in biological sciences will be helpful. The course will focus on the design and
implementation of genetic epidemiology studies for application in basic research,
diagnostics and pharmacogenetics. We will explore concepts of inheritance and
molecular genetics; evidence for genetic component in disease; family-based and
case-control study designs for finding genes associated with disease; analytical
concepts such as haplotype determination, linkage disequilibrium, population
stratification and gene-environment interaction and interpretation of the literature.
We will be discussing these and many other issues surrounding this fascinating
and relatively young branch of epidemiology that is rapidly growing to bridge the
gap between epidemiological practice and genetic knowledge.
STAT 500
Deven Shah
STAT 518
H. M. James Hung*
Sue-Jane Wang
epidemiological data are emphasized. The interpretation of models and fits, rather
than mathematical details of computational procedures is emphasized.
Prerequisite: STAT 200, or STAT 500 or equivalent.
STAT 525
H. M. James Hung*
Sue-Jane Wang
STAT 529
H. M. James Hung*
Sue-Jane Wang
This course covers statistical methods for the analysis of censored time event
data. Topics include introduction to survival analysis and failure-time data; survival,
hazard, cumulative hazard function; failure time models; nonparametric methods,
product limit (Kaplan-Meier) estimator, Greenwoods formula; proportional hazards
(Cox) regression model; accelerated failure time model and rank regression;
graphical methods for survival distribution fitting and assessing goodness of fit.
The theoretical motivation and interpretation of computational procedures are
emphasized.
Prerequisite: STAT 200, or STAT 500, or equivalent.
BIOF 309
Introduction to Python
(See page 8)
BIOF 312
Introduction to Perl
(See page 8)
BIOF 518
Theoretical and Applied Bioinformatics
(See page 9)
BIOF 537
Computational Biology
(See page 9)
This course covers statistical methods for the analysis of structured, counted data.
Topics include Poisson, multinomial, and product-multinomial sampling models;
exact and asymptotic chi-square and likelihood ratio tests; log-linear models for
cross-classified counted data, including models for data with ordinal categories;
data of repeated categorical response; logistic regression and generalized linear
models; and measures of association. Applications to biological, clinical, and
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FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
MEDI 303
Matthew Rittler
Laurie Shuman Moss
Marni N. Silverman
Srikumar Sinnarajah
Esther M. Sternberg
Kuei-Meng Wu
MEDI 211
Fall, 2 credits
Francesco S. Celi
The objective of this course is to provide the student with elementary knowledge
on the principles of endocrine physiology and pathophysiology. This is an
elementary course that presumes only a modest background in general biology
and general chemistry. Holders of a graduate degree in any area of vertebrate
biology are discouraged from enrolling. The course will describe problems that
the organism solves by means of hormones and deals with the biochemical
mechanisms by which the different families of hormones (peptides, steroids, and
tyrosine derivatives) are synthesized, stored, released, transported, act on their
target tissues, and are degraded.
MEDI 217
Human Physiology I: Neural,
Cardiovascular, Pulmonary,
Sensory, and Neonatal Systems
Fall, 2 credits
Srikumar Sinnarajah
Basic Human Physiology from an integrated function and a health and disease
perspective. The relationships between normal function and disease are
examined; the impact of history and physiological research on medicine and
physiology is discussed. No laboratory included.
Fall, 3 credits
Kuei-Meng Wu
Joshua Hunsberger
And Guest Lecturers
MEDI 316
Biology of Cancer
This course introduces the student to important and timely concepts in Cancer
Biology. Initial lectures will focus on the hallmarks of cancer, basic terminology,
and the profile of cancer cell, as well as a discussion on the causes of cancer
including genetics, infectious agents (viruses) and environmental/chemical/
radiation exposure. Subsequent lectures will focus on the mechanisms of cancer
including an overview of oncogenes and tumor suppressors, cell control by signal
transduction pathways and their role in cancer, discussing the role of cell cycle,
cell death/survival pathways and DNA damage and check-point/DNA repair. The
course will also include lectures on rapidly evolving topics such as understanding
the tumor microenvironment, current models for studying cancer, miRNAs and
their role in cancer, epigenetic control of the cell, current opinions on cancer stem
cells, and the rationale behind cancer treatments.
Registration is limited to 25 students.
MEDI 326
Introduction to Global Health
MEDI 302
Fall, 2 credits
Spring, 2 credits
Linda Kupfer
and Guest Lecturers
Global Health has been described as an area for study, research and practice
that places a priority on improving health and achieving equity in health for all
people worldwide (Koplan J, 2009. Lancet. 373:1993). Within the course, a
broad snapshot of global health will be presented, providing students with
insight into the challenges currently facing global health. Participants will also
gain an understanding of why tackling global health issues is such an important
endeavor with the potential to reduce poverty, build stronger economies and
promote peace. Students will not only be exposed to the major communicable
and non-communicable diseases posing a profound effect on health (especially
within the developing world) but will also discover how socio-economic and
demographic differences can influence the burden of disease. A number of
other critical underlying factors including environmental, behavioral and cultural
influences will also be presented. Through the use of case reports from around
the world, the course will also explore how research findings are transferred into
policy and practice. Students will be encouraged to understand that solving global
health problems requires the input of multiple disciplines. To emphasize this
point, speakers will be drawn from multiple fields including the sciences, ethics
economics and diplomacy.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
35
Fall, 2 credits
Matthew Rittler*
Laurie Shuman Moss
This is a 14 week starter course that will cover the initiation and progression
of cancer, focusing on the tumor microenvironment and metastasis. Topics will
include primary tumor growth, the metastatic process, secondary tumor growth,
epithelial to mesenchymal transition, adhesion , and angiogenesis. This course
will also have a journal club component, which will enable students to read and
present a scientific journal article related to the course.
Note: Advanced does not refer to the difficulty of the course, but rather the more
specific topics covered in the course. The material presented is for all background
levels.
MEDI 507
William Gahl*
Meral Gunay-Aygun
The objective of this course is to learn the principles and practice of human
biochemical genetics. Students will research a topic and present the lectures. The
faculty will add to the class by offering experience, and when possible, presenting
individual cases. Topics to be covered include amino acidopathies, organic
acidoses, disorders of carbohydrate metabolism and lipid metabolism, lysosomal
storage diseases, peroxisomal diseases, purine and pyrimidine disorders, and a
variety of other inborn errors of metabolism. Several quizzes are planned and
student participation will be strongly encouraged.
This is an advanced course, largely geared toward PhDs and MDs.
Prerequisite: Graduate degree
MEDI 522
Neural-Immune Interactions
in Health and Disease
Spring, 2 credits
Marni N. Silverman*
Esther M. Sternberg
This newly recognized discipline studies interactions between the immune and
nervous systems at all levels from molecular and cellular to neuroanatomical,
neuroendocrine, behavioral and clinical. The course will cover molecular aspects
of these interactions, including neural and immune mediators and their receptors,
which may be members of the same superfamily or may regulate each others
expression or function. The course will also cover mechanisms and effects
of interactions between cytokines, neuropeptides and neurotransmitters. An
important focus will be the physiological role of cytokines expressed within the
brain and the pathological consequences of their over-expression in the CNS. The
course will also cover mechanisms by which peripheral cytokines signal the brain,
via transport across the blood brain barrier and second messenger signaling. It
will address the physiological effects of peripheral cytokines signaling the CNS,
and the pathophysiological consequences of disruptions or perturbations of
these communications on expression of autoimmune/inflammatory and infectious
diseases. The course will also cover non-hormonal, sympathetic, parasympathetic
and peripheral nerve mechanisms of communication between the nervous and
immune systems, and the pathophysiological effects of these communications.
Also covered will be aspects of human clinical conditions in which these
communications play a role: illnesses of the stress response; the effects of stress
36
MEDI 550
Introduction to the Principles and
Practice of Clinical Research
Frederick P. Ognibene
John I. Gallin
and Guest Lectures
MEDI 552
Demystifying Medicine for PhD Students,
Fellows and Staff
Spring, 2 credits
Irwin M. Arias
The goal of this novel course is to demystify medicine primarily, but not exclusively,
for PhD scientists through clinical presentations, analysis of the pathobiology
of major human diseases and bridging this information with advances in basic
biology. Clinician students, fellows and staff are also encouraged to participate.
Participants will interview selected patients, see pathologic specimens and
learn about major current diagnostic and therapeutic procedures. The class
will be heterogeneous in composition. The teaching staff will include clinicians,
pathologists and basic scientists. Three preview and two additional supplemental
lectures are being offered outside of the regularly scheduled semester. The course
is based on a highly successful venture conducted at Tufts University School of
Medicine for the past 19 years and for the past four years at NIH. To receive
academic credit for this course the student must register with FAES, pay tuition,
attend the sessions and complete a final takehome exam. Those wishing to audit
this course, can register directly with the instructor by email with no tuition charge.
This course is an elective for the Technology Transfer Certificate Program.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
BIOF 502
Medical Genomics for Clinicians and Researchers
(See page 9)
MEDICAL SUBSPECIALTY
REVIEW COURSES
A series of review courses covering textbook material with special emphasis on
recent developments. These courses are designed specifically as preparation for
forthcoming Subspecialty Board Examinations.
MEDI 723
A Review of Endocrinology:
Diagnosis and Treatment
BIOF 552
Medical Genomics for Clinicians and Researchers
(See page 10)
Lee Weinstein
and Guest Lecturers
MEDI 725
Guest Lecturers
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
37
38
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Prerequisite: Calculus.
Spring - This course includes the topics of drug transport mechanisms and
their relevance in pharmacokinetics and drug metabolism, dose response and
concentration response analysis, biological markers of drug effect, and adverse
drug reactions. In addition, emphasis is given to optimizing and evaluating the
clinical use of drugs, as well as drug therapy in special populations (children,
elderly adults, pregnant and nursing women). A special course module focuses on
the processes of drug discovery and development, and the regulatory role of the
FDA. January 5 April 26, 2012.
PHAR 359
Spring, 3 credits
Kuei-Meng Wu
PHAR 511
Current Concepts in Pharmacology
and Therapeutics
Spring, 3 credits
Fredrick Lombardo
Frank Pucino*
PHAR 400
Pharmacology
Chhanda Dutta
S.N. Dutta
Robert S. K. Young*
PHAR 500
Juan Lertora
and Guest Lecturers
TOXI 303
Introductory Toxicology
Fall, 2 credits
Robert Mitkus
Thursdays 6:30-7:45 pm
Tuition: $290 per semester
Fall - This course provides a basis for understanding the scientific principles
of rational drug therapy and contemporary drug development, with emphasis
on pharmacokinetics, methods for drug analysis, drug metabolism, and
pharmacogenetics. Topics include the physiologic and pathophysiologic
factors involved in drug absorption, distribution, metabolism and elimination,
determinants of variability in drug responses, inter- and intra-patient variability
in pharmacokinetics and pharmacodynamics, and drug interactions. This course
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
39
Spring, 3 credits
Fred Lombardo
Arvind K.N. Nandedkar*
40
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
The overall goals of the Certificate in Public Health Program are to give
professionals an overview of and build competencies in the five core
disciplines of public health (as defined by the Association of Schools of
Public Health (ASPH) (http://www.asph.org/userfiles/version2.3.pdf) -epidemiology, biostatistics, environmental health sciences, health policy
and management, and social and behavioral sciences. In addition, students
will demonstrate their understanding of this core disciplinary knowledge
and practice by conducting a Capstone Project. Upon completion of this
program, a graduate will be able to:
EPIDEMIOLOGY
Epidemiology is the study of patterns of disease and injury in human
populations and the application of this study to the control of health
problems. (http://www.asph.org/userfiles/version2.3.pdf, page 10)
BIOSTATISTICS
Biostatistics is the development and application of statistical reasoning
and methods in addressing, analyzing and solving problems in public
health; health care; and biomedical, clinical and population-based
research. (http://www.asph.org/userfiles/version2.3.pdf, page 10)
HEALTH POLICY AND MANAGEMENT
Health policy and management is a multidisciplinary field of inquiry and
practice concerned with the delivery, quality and costs of health care for
individuals and populations. This definition assumes both a managerial
and a policy concern with the structure, process and outcomes of health
services including the costs, financing, organization, outcomes and
accessibility of care. (http://www.asph.org/userfiles/version2.3.pdf,
page 10)
SOCIAL AND BEHAVIORAL SCIENCES
The social and behavioral sciences in public health address the behavioral,
social and cultural factors related to individual and population health and
health disparities over the life course. Research and practice in this area
contributes to the development, administration and evaluation of programs
and policies in public health and health services to promote and sustain
healthy environments and healthy lives for individuals and populations.
(http://www.asph.org/userfiles/version2.3.pdf, page 10)
ENVIRONMENTAL HEALTH SCIENCES
Environmental health sciences represent the study of environmental
factors including biological, physical and chemical factors that affect the
health of a community. (http://www.asph.org/userfiles/version2.3.pdf,
page 10).
Required Courses:
PBHL/STAT 317 - Introduction to Epidemiology (offered by the Department
of Mathematics, Epidemiology and Statistics) - Using lectures, problem
sets, and outside reading, this course provides an introduction to the
principles and methods of epidemiology, defined as the study of the
distribution and determinants of disease frequency in man.
PBHL/STAT 500 - Statistics for Biomedical Scientists (Year course)
(offered by the Department of Mathematics, Epidemiology and Statistics)
- The objective of this course is to provide an overview of statistics for
biomedical researchers, clinicians, and students in public health who
are interested in the interpretation of results of statistical analyses. This
course uses a series of integrated lectures on analysis and interpretation
of medical and public health research data. Emphasis is on ideas and
understanding rather than on mechanics. Topics covered in the first
semester include the foundation of statistical logic and the most commonly
encountered statistical procedures in medical and public health research.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
41
42
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Public Health
Stephen E. Marcus, Chairperson
David A. Broniatowski
Paula Goodwin
Chris Hafner-Eaton
Harry T. Kwon
Margaret A. McDowell
David E. Nelson
John Parascandola
Sarah M. Pope
PBHL 507
PBHL 501
New
Fall, 2 credits
Harry T. Kwon
David E. Nelson
New
PBHL 511
Fall, 2 credits
Introduction to
Margaret A. McDowell
Applied Public Nutrition
Strategies to Improve Population Health
This course will introduce the student to the concepts and principles
of public health nutrition. Emphasis will be on population health and
the methods, policies, and strategies to assess and alleviate diet-related
chronic diseases. A socio-ecological framework will be used to explore
the societal, economic, environmental, and institutional barriers to optimal
nutritional status and health among diverse populations. Case studies will
be used to illustrate innovative strategies, policies, and programs that have
been developed to improve the nutritional status of diverse communities.
The course will be conducted in a seminar style and will include readings,
guest lectures, web-based activities, and interactive discussion.
PBHL 512
Social and Behavioral Sciences
Spring, 3 credits
Paula Goodwin
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
43
New
PBHL 517
Fall, 3 credits
PBHL 519
Health Disparities
Paula Goodwin
New
PBHL 5xx
John Parascandola
Chris Hafner-Eaton
44
New
New
PBHL 5xx
One basic principle that the field of public health is based on is that
every person has the right to a standard of living adequate for the health
and well-being of himself and his family (Article 25 of the Universal
Declaration of Human Rights). This course will explore historic and
contemporary ethical issues raised in public health. Upon completing this
course, students will be able to identify and critically analyze key ethical
dilemmas and the relevant stakeholders in public health while exploring
the societal, cultural, religious, and moral values that influence the ethical
decision-making process.
New
PBHL 602
Spring, 3 credits
David A. Broniatowski
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
New
PBHL 607
Stephen E. Marcus
PBHL/MICR 418
(See page 28)
Emerging Infectious Diseases
PBHL/MEDI 326
(See page 35)
Introduction to Global Health
PBHL/STAT 318
(See page 33)
Statistical Methods in Epidemiology
PBHL/STAT 321
(See page 33)
Methodology in Clinical Trials.
PBHL/STAT 322
(See page 33)
Intermediate Epidemiology
PBHL/STAT 500
(See page 34)
Statistics for Biomedical Scientists
PBHL/TECH 512
(See page 49)
Global Bioethics for Scientists and Administrators
PBHL/TECH 586
(See Page 52)
International Science Technology and Innovation Policy
PBHL/TOXI 303
(See page 39)
Introductory Toxicology
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
45
General Requirements:
The Certificate Program will be open to anyone with a degree in Science
or Engineering, and may be completed in approximately 2 years. Courses
are offered in the evenings, making it convenient for working professionals
and Post-doctoral Fellows contemplating non-traditional careers.
Students who wish to receive the Certification will be required to take a
total of 15 credit units, with 12 units of in-class coursework, and a final
independent project of 3 units. The required courses include: TECH 513,
TECH 565, and TECH 607. The elective courses include: TECH 512,
TECH 521, TECH 566, TECH 567, TECH 572, TECH 575, TECH 576,
TECH 579, TECH 584, TECH 592, TECH 501,TECH 503, TECH 504,
CHEM 327, PHAR 511 and MEDI 552. For students who have already
completed some of these courses, such credits can be applied towards
the Certificate. At the end of all the coursework, students can receive the
Certificate by contacting Ms. Audrey Lyons, the Registrar of the Graduate
School.
46
Required Courses:
TECH 513- Introduction to Technology Transfer- An introductory course
that covers the history of the field and provides an overview of patenting,
licensing, collaborative agreements and other fundamental intellectual
property transactions.
TECH 565- Biomedical Business Development for Scientists- A practical
hands-on course intended to expose students to the concepts of business
planning, venture capital, technology transactions and commercialization.
TECH 607- Capstone Course in Technology Transfer- Through this
mentored course, the student would be required to spend approximately
one day per week for the duration of the semester at an appropriate
professional office where they would put some of their classroom learning
into practice.
Elective Courses:
TECH 501 Inside and Outside the FDA This course provides an
introduction to various elements and strategies used in navigating FDA
regulatory requirements with a perspective from both inside the FDA and
inside industry to FDA regulations.
TECH 503 Business Law Primer for Life Science Entrepreneurs This
course provides the student with a working practical knowledge of certain
essential substantive areas of the law and the ability to select, work with
and use lawyers effectively.
TECH 504 FDA Regulatory, Industry, and Hidden Intellectual Property
This course provides a deeper exploration of how FDA regulation shapes
business decisions inside of industry as well as the cost-analysis that
industry used to make regulatory decisions and the intellectual property
that is generated in-house throughout the product life.
TECH 512 Global Bioethics for Scientists and Administrators - The
purpose of this interdisciplinary course is to conduct ethical analyses of
a cluster of cutting edge issues in order to understand the human values
and policy issues at stake.
TECH 521 Tools for Technology Transfer- This course will focus on the
nuts and bolts of technology transfer. A team of NIH technology transfer
professionals will focus on the various types of agreements, contracts and
collaboration mechanisms used in the field and address potential issues
or problems that one may encounter when negotiating the agreements.
TECH 566 Biotechnology Business Leadership and Management
Strategies- Through on-site visits, review of company literature and
lectures, the students will study the strategies and management of various
life science companies. A number of managerial functions such as senior
management, finance, R&D, manufacturing, marketing and human
resources will be examined and each student will be required to present a
summary of their findings and recommendations.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
47
Julie Muroff
Frederick Provorny
Uri Reichman
Michael Salgaller
Luis A. Salicrup
Erika R. Smith
Brian R. Stanton
Rosemarie Truman
Jeff Walenta
Sury Vepa
New
TECH 501
Inside and Outside the FDA
This course provides an introduction to various elements and strategies
used in navigating FDA regulatory requirements with a perspective
from both inside the FDA and inside industry to FDA regulations. It
explores the organization of the FDA, what is regulated by the FDA,
and how the FDA enforces those regulations. The course also covers
how the industry complies with the FDA, what happens when they do
not, and how compliance effects internal business decisions. In most
biotech organizations today, medical technology created is subject to
FDA regulation. This course will discuss the product life cycle, regulatory
requirements pre-market and post-market, and other elements of
compliance necessary for corporate success. Students will learn the role
the FDA plays in the development of new medical technologies and how
corporations big and small are affected.
This course is an elective for the Technology Transfer Certificate Program
TECH 503
Business Law Primer for
Life Science Entrepreneurs
Fall, 2 credits
Frederick Provorny
Sury Vepa
48
TECH 504
TECH 506
Researcher Commercialization
Steve Ferguson
Webinar Course: The Essentialsand the National
Center for Entrepreneurial Tech Transfer (NCET2)
This online webinar course is designed for researchers in research
institutions (e.g., grad students, post-docs, professional staff and
faculty) and researchers in commercial companies (e.g., startups, SBIRfunded firms, research-based small businesses and Global 1000). It
allows attendees to make an informed decision as to how to better plan
their commercialization efforts, be it through employment, licensing,
consulting, joint venturing, or startup creation. The course itself will deal
with successfully commercializing any type of research activity, whether
focused on engineering, physical sciences or life sciences, and not specific
to just NIH. The topics themselves will introduce the practical business and
legal issues that researchers need to understand to commercialize their
research. The course will start with the different ways to commercialize
research, ranging from the traditional (i.e., employment and licensing)
to the more entrepreneurial (i.e. consulting, joint venturing/strategic
alliance and startup company). It will show how these commercialization
methods overlap and how they differ. These sessions will also deal
with fundamental topics like intellectual property, licensing agreements,
employment agreements and consulting agreements, which researchers
must understand regardless of whether they intend to be researchers at a
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
university lab or the founder of the next great public company. The second
half of the course will give an introduction to the advance topics of creating
and funding companies. The main difference between the fundamental
and advance topics is that the fundamental are basically personal topics
that every researcher needs to know in their commercialization efforts. The
advance topics deal with commercializing as a group, with the resulting
complexities of understanding the relationships and expectations of the
other team members in the company, be they other employees, founders,
executives, board members, shareholders, investors or partners.
Each lecture is a 90-minute webinar that can be viewed live or off-line on
at www.ncet2.org. There will be expert guest speakers for each session.
FAES registration will be necessary only to take the course for academic
credit.
This course is an elective for the Technology Transfer Certificate Program.
TECH 512
Gladys White
TECH 513
Introduction to Technology Transfer
Spring, 2 credits
Susan Ano
Steven M. Ferguson*
TECH 521
Tools for Technology Transfer
Fall, 2 credits
Bruce Goldstein
TECH 565
Biomedical Business Development
for Scientists
Fall, 2 credits
Steve Ferguson*
Michael Salgaller
Jeff Walenta
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
49
Spring, 2 credits
Steve Ferguson
Yali Friedman*
Jeff Walenta
This course will take a practical, hands-on approach to study the strategies
and management of biotechnology and biomedical firms. There will be
a review of specific businesses and their development, funding options
(financial markets, venture capital etc.) and technology transactions
(including royalty arrangements and strategic partnering). Focus will be
on critical thinking and management/human capital decisions during
times of conflict and growth. Senior management and scientists will
offer their individual stories about their operational challenges. The
course will include onsite visits and lectures relating to various sized
biotechnology companies in the region. Students will critically review
company annual reports and business write-ups as background prior to
these presentations and visits. Firms chosen to understand operational
perspectives will include companies from a wide variety of biomedical
business sectors: medical devices, laboratory reagents, diagnostics,
drug discovery, pharmaceuticals and service providers. A wide variety of
managerial functions within these organizations will be examined, such
as senior management, human resources, finance, R&D, marketing and
manufacturing. Students will provide oral presentations after such visits
and engage in group discussions on the issues identified and potential
solutions to business/science problems. The students will provide written
feed back to the management of these companies that summarize their
discussions.
Registration limited to 15 students.
Prerequisites: Basic or advanced knowledge of science. TECH 565 helpful,
but not required. No business credit required.
This course is an elective for the Technology Transfer Certificate Program.
Preference will be given to students taking the course for credit toward a
certificate in Technology Transfer.
TECH 567
International Strategic Partnering and
Business Development
Fall, 2 credits
TECH 572
Marketing Strategies for Scientific
Organizations
Spring, 2 credits
Barry Datlof
Rita Khanna
This course will take a practical look at the growing global market place for
innovative biomedical products and research with a focus on the business
planning, market development, venture capital, technology transactions,
and relevant international partnerships. Using current examples from the
active global portfolio of NIH or other organizations, the students will be
able to compare activities coming out of US and foreign countries to learn
and to review scientific innovation and to determine whether a particular
discovery constitutes a realistic business proposal from an international
perspective.
This course seeks to understand international S&T cooperation. It also
seeks to understand the dynamics of U.S. foreign policy, especially
where cooperative S&T is used as an important tool in promoting U.S.
international health, economy, and trade objectives. Case studies will be
featured. Topics include: definition of international S&T cooperation, its
past and present applications; U.S. strategic objectives associated with
it; and the major forms and types of international agreements particularly
those involving NIH. The course will look at the history of international
50
venture capital and its relation to science and technology. The course will
emphasize technology transfer issues related to the new world royalty
structures, technology partnerships and venture capital investments.
Students will be expected to assess a technology of their choice, and
develop a draft executive summary of a new bio business concept with
potential commercial advantage in the international market place or write
a research paper on one of the topics covered. Such student efforts may
be selected for use in commercialization efforts by the NIH Office of
Technology Transfer, presentation to international business plan groups,
or for publishing in an international journal. The course will provide a
real world flavor by including lectures by seasoned scientists, CEOs,
investors and other executives that play major roles in international or
global markets.
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
TECH 575
Fall, 2 credits
TECH 576
Topics in Business Management
For Scientists
Spring, 2 credits
Uri Reichman
TECH 582
Intellectual Property and Patent
Prosecution for Scientists
Spring, 2 credits
Lee Heiman*
Brian Stanton
TECH 579
Negotiation Workshop
Fall, 2 credits
Julie A. Muroff
TECH 584
Medical Product Development
Spring, 2 credits
Sabarni Chatterjee
Tara Kirby
Erika R. Smith*
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
51
New
TECH 586
Spring, 2 credits
Luis A. Salicrup
New
TECH 587
Fall, 2 credits
52
TECH 592
Spring, 2 credits
Public-Private Partnerships
Barbara B. Mittleman
TECH 607
Steve Ferguson*
Frederick Provorny
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
Busby, Benjamin, Ph.D., University of Maryland at Baltimore; Postdoctoral Fellow, Evolutionary Genomics Research Group, National
Center for Biotechnology Information, National Library of Medicine,
National Institutes of Health. 301-594-2698.email:ben.busby@gmail.com
Cceres, Jos, M.M., University of Maryland, Pianist, teacher, master
class leader, adjudicator (private studio). 202-289-8353.
email:caceres@josecaceres.com
Celi, Francesco S., M.D., University of Rome La Sapienza, Rome,
Italy; Staff Clinician, Clinical Endocrinology Branch, National Institute
of Diabetes and Digestive and Kidney Diseases, National Institutes of
Health. 301-435-9267. email: fc93@nih.gov
Chatterjee, Sabarni, Ph.D., State University of New York, Binghamton;
Licensing and Patenting Associate, Office of Technology Transfer,
National Institutes of Health. 301-435-5587.
email: chatterjeesa@mail.nih.gov
Chernomordik, Leonid V., Ph.D., The A.N. Frumkin Institute of
Electrochemistry, Russian Academy of Sciences; Section Head, Senior
Investigator, Section on Membrane Biology, Laboratory of Cellular and
Molecular Biophysics, Eunice Kennedy Shriver National Institute of Child
Health and Human Development, National Institutes of Health.
301-594-1128. e-mail: lchern@helix.nih.gov
Chyatte, Jeffrey, DDS., University of Maryland, Professor of Anatomy
and Physiology, Montgomery College 301-650-1453,
email: Jeff.Chyatte@montgomerycollege.edu
Datlof, Barry, M.B.A., University of Chicago; Managing Partner,
Pregmama LLC. 301-332-2548. email:FAES@datlof.com
Davies, David, Ph.D., Oxford University; Section Chief, Laboratory
of Molecular Biology, National Institute of Diabetes and Digestive and
Kidney Diseases, National Institutes of Health. 301-496-4295.
email: david.davies@nih.gov.
Dogan Islamaj, Rezarta, Ph.D., University of Maryland at College
Park; Research Fellow, National Center for Biotechnology Information,
National Library of Medicine, National Institutes of Health. 301-435-8779.
email:Rezarta@gmail.com
Dong, Lijin, Ph.D., University of Pittsburgh; Staff Scientist, Genetic
Engineering Core, National Eye Institute, National Institutes of Health.
301-402-5296.email:dongl@nei.nih.gov
Durum, Scott K., Ph.D., Oak Ridge Associated Universities; Senior
Investigator, Laboratory of Molecular Immunoregulation, Frederick
Cancer Research Center, National Cancer Institute, National Institutes of
Health. 301-846-1545. email: durums@ncifcrf.gov
Dutta, Chhanda, Ph.D., Uniformed Services University of the Health
Sciences; Director, Musculoskeletal Research, Geriatric Program,
National Institute on Aging, National Institutes of Health. 301-435-3048.
email: cd232@nih.gov
Dutta, S.N., M.D., Calcutta University; Ph.D., Howard University; Food
and Drug Administration (retired)
FA E S G R A D U AT E A N D U N D E R G R A D U AT E C O U R S E S AT N I H 2 0 1 1 - 2 0 1 2
53
Gallin, John I., M.D., Cornell University; Director, NIH Clinical Center;
Laboratory of Host Defenses, National Institute of Allergy and Infectious
Diseases, National Institutes of Health. 301-496-4114.
email: jig@cc.nih.gov
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Major, Jacqueline, Ph.D., University of California-San Diego; Postdoctoral Fellow, Division of Cancer Epidemiology and Genetics, National
Cancer Institute, National Institutes of Health, 301-451-9873.
email:gsph.jm@gmail.com
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Sorlie, Paul D., Ph.D., Johns Hopkins University School of Hygiene and
Public Health; Epidemiologist-Statistician, Epidemiology and Biometry
Program, National Heart, Lung and Blood Institute, National Institutes of
Health. 301-435-0456. email: sorliep@nih.gov
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White,
Gladys B., Ph.D., Georgetown University; Adjunct Professor,
W
Georgetown
University and Montgomery College.
G
Email:gladys.white@comcast.net
E
Wu,
W Kuei-Meng, Ph.D., University of Kentucky; Senior Expert
Pharmacologist,
Department of Health and Human Services. 301-796P
0835.
email: drkmwu@gmail.com
0
Xu,
X Xuehua, Ph.D., Tsukuba University, Japan; Staff Scientist, NIAID,
National
Institutes of Health. 301-594-0692. email:xxu@niaid.nih.gov
N
Yang,
Wei, Ph.D., Columbia University; Section Chief, Laboratory of
Y
Molecular
Biology, National Institute of Diabetes and Digestive and
M
Kidney
Diseases, National Institutes of Health. 301-402-4645. e-mail:
K
wei.yang@nih.gov
w
Young,
Robert S. K., M.D., Ph.D., Yale University; J.D., LL. M.,
Y
Georgetown
University; Center for Drug Evaluation and Research, Food
G
and
a Drug Administration. 301-594-1032. email: bob.young@fda.hhs.gov
Yun,
Y Sijun, Ph.D., Boston University; Postdoctoral Fellow, Laboratory of
Cell
C Biology, National Cancer Institute, National Institutes of Health.
301-496-1397.
email:yuns@mail.nih.gov
3
Zarate,
Jr., Carlos A., M.D., Faculty of Medicine, Catholic University of
Z
Cordoba,
Argentina; Chief, Mood Disorders Research Unit, , Mood and
C
Anxiety
Disorders Program, National Institute of Mental Health, National
A
Institutes
of Health. 301-451-0861. email: zaratec@mail.nih.gov.
In
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