DR.

MAMMEN CHANDY
Name
:
Sex
:
Designation :

Dr Mammen Chandy
Male.
Director, Tata Medical Centre

Contact Details:

Dr. Mammen Chandy MD, FRACP, FRCPA

Director
Tata Medical Center
1, Bishop Lefroy Road, Kolkata - 700020
T : (91) 9894481640, 033 22810175
E : mammen.chandy@tmckolkata.com

Educational Qualifications.
1.
Undergraduate
M.B.B.S. 1971 CMC Vellore Madras University.
2.
Post Graduate M.D.[Medicine] 1978 CMC Vellore Madras University.
3.
Speciality
FRACP.*,FRCPA**, [Hematology] 1985 Sydney, Australia
* Fellow of the Royal Australasian College of Physicians.
** Fellow of the Royal College of Pathologists of Australasia.

Details of Training and Experience.

1. Undergraduate.
Five and a half years of undergraduate medical education at the Christian Medical College and
Hospital .One year rotating internship in medicine, surgery, obstetrics and gynecology and
community medicine.
2. Post Graduate
Three years training in internal medicine with postings in specialties: cardiology, neurology,
nephrology, psychiatry and dermatology.
3. Specialty Training.
Two and a half years at the Westmead Centre Sydney Australia. Training in general hematology
and clinical management of patients with hematologic malignancy, coagulation disorders and
general hematology problems. Laboratory experience with immunophenotyping and soft agar
bone marrow cultures. Experience in clinical bone marrow transplantation and experimental work
on T cell depletion in marrow transplants in beagles.

Academic Appointments
1979-1980: Junior Lecturer, Department of Medicine, Christian Medical College Hospital,
Vellore.
1980-1983: Lecturer, Department of Medicine, Christian Medical College Hospital, Vellore.
During this period completed specialty training at the Westmead Center,
Sydney, Australia.
1983-1985: Reader, Department of Hematology, Christian Medical College Hospital,
Vellore.
1985-1987: Associate Professor, Department of Hematology Christian Medical College
Hospital, Vellore.
1987- 31st March 2010: Professor, Department of Hematology Christian Medical College
Hospital, Vellore.
1994-1996: Appointed as Professor of Hematology, Sultan Qaboos University Hospital,
Muscat, Oman. [On sabbatical]
1st April 2010: Director, Tata medical Center, Kolkata, India

Administrative Appointments
Head Department of Hematology: 1987 to 2007
Associate Director HRD, CMCH Vellore: February 2000 to Jan 2004

Research Projects:
1. Evaluation of the National Nutritional Anemia Prophylaxis Program. Indian Council of Medical
Research Grant 5/9/6/10/1984.
2. Field Supplementation Trial with 60.120,180 and 240 mg of iron with 500mcg of Folic acid.
Indian Council of Medical Research. Grant 5/9/6/18/1984.
3. Collaborative study on Hemophilia. Indian Council of Medical Research Grant 46/2/1985.
4. Evaluation of Immunosupression with anti T cell monoclonal antibody WM48 in the treatment
of severe Aplastic anemia. Indian Council of Medical Research.Grant5/3-2(7)/1987-BMS II.
5..Advanced center for Bone Marrow Transplantation in Thalassemia in India. Dennison D, Chandy
M and Srivastava A. Indian Council of Medical Research. Grant
6. Center for molecular genetics for the diagnosis of hematological disorders at the Christian
Medical College, Vellore. Department of Biotechnology. 1998.
7. Molecular remission with Arsenic trioxide in acute Promyelocytic leukemia (Indian APML Study
Group IASG) Department of Biotechnology Grant No BT/PR 4460/MED/14/531/2003

8. Molecular genetics of Thalassemia, hereditary Bleeding Disorders and Leukemia. Department of

Biotechnology Grant BT/MB/04/2004.
9. Training Center for Molecular genetics in hematological Disorders at Christian medical College
Vellore. Department of Biotechnology Grant BT/PR6022/MED/12/241/2005
MEMBER
1. Chair Task Force on Human Genetics and Genome analysis. Department of Biotechnology.
Government of India. Ministry of Science and Technology. 2005
2. Member Medical Biotechnology Development Board Department of Biotechnology.
Government of India. Ministry of Science and Technology. 2005
3. Scientific advisory committee .Basic Medical Sciences Division. Indian Council of Medical
Research.
4. Scientific advisory committee: Institute of Immunohaematology.
5. Scientific advisory committee; Tata Memorial Hospital.
6. Editorial Board. Indian Journal of Haematology.
7. Reviewer : Indian Journal of Medical Research.
8. Reviewer: National Medical Journal of India.
9. Member: .Indian Society of Hematology and Blood Transfusion.
10 Member of Executive Committee of the World federation of hemophilia
11. Member American Society of Hematology

PUBLICATIONS
1. Pothen J,Chandy M,Padmanabhan N,Richard J,Pulimood BM. Systemic lupus eryhtematosus.A
study from South India. JAPI.1982:30,8;485-499.
2. Date A,Chandy M and Pulimood BM. .Filarial chyluria with opportunistic infections Trans Royal
Soc Trop Med Hyg.1983;77,1:112-113.

3. Jose J,Alexander T,Mathai D,Chandy M and Pulimood BM. Blast crisis in Chronic Myeloid
leukaemia.JAPI.1987;135,2:127-129.
4. Koshy G,Anandi V,Chandy M,and Jeyaray PS. Development of a co-agglutination technique to
detect candida antigenaemia; CoA versus candida isolation.Am J Clin Path.
5. Chandy M. Everyday Practice : Blood component therapy. National Medical Journal of India.
1991;4,4:191-193.
6. Chudgar U,Shah RV,Krishnaswamy H and Chandy M. Hairy Cell leukaemia - a review of nine
cases. Indian Journal of Cancer. 1991;28:155-161.
7. Dennison D,Vaughan WP,Chandy M.Srivastava A and Pulimood BM. Bone Marrow
Transplantation in India: Appropriate or Inappropriate technology ? International Third World
Studies and Review.1990;2:1-5.
8. Hariharan J,Muralidharan M, Korula R and Chandy M. Hickman Catheter implantation in the
treatment of acute leukaemia.JAPI.1991;39,2:168-170.
9. Chudgar UH, Chandy M, Pulimood RBP and Khanduri U. Slow thaw siphon technique for
cryoprecipitate production. Ind J Med Res.1989;90:295-299.
10. Jasper MP, Khanduri U and Chandy M. Von Willebrand's disease complicating pregnancy and
labor. Ind Jr Obst Gyn 1990.203-206.
11. Chandy M, George Babu P. Saraswathy NK, Ishida T and Jacob John T. HTLV-1 infection in
patients with leukaemia in southern India. Lancet.1991;338:380-381.
12. Patel AP, Chandy M, Sudarsanam A. Refractory chronic pure red cell aplasia [PRCA] treated
with Vincristine and Daunorubicin. Br J Haematology.1991.78:3,457-458.
13. Chandy M. Bone Marrow Transplantation - A review. Ind J Haematology. 1989;VII,4:149-159.
14. 14.Chandy M. Report of the Collaborative study on Haemophilia.Indian Council of Medical
Research.1991.Editor.
15. Chandy M. Symposium on Inherited Coagulation Disorders.Clinical Approach :Ind J of
Haemat.1991;IX,2:53-56.
16. Patel AP, Chandy M. Raghupathy P,Kirubakaran C,Khanduri U. Hereditary Factor XIII Deficiency.
Indian J Pediatr 1993;60:441-444.

17. Chandy M. Disordered Haemostasis

Haematology.1991;IX,4:157-158.

in

Leukaemia.Editorial.

Indian

of

18. Mansoor AM, Bharadwaj TPR, Sethuraman S, Chandy M, Pushpa V, Kamada N and
Balakrishnamurthy P. Analysis of karyotype, SCE and Point mutation of RAS oncogene in India
MDS patients. Cancer Genet Cytogenet.1993.65;12-20.
19. Chandy M. Childhood Acute Lymphoblastic Leukaemia in India: An approach to management
in a three-tier society. Medical and Paediatric Oncology.1995, 25: 197-203
20. Sequence analysis of human T-cell lymphotropic virus type I strains from southern India: gene
amplification and direct sequencing from whole blood blotted onto filter paper. Nerurkar VR,
Babu GP, Song KJ, Melland RR, Gnanamuthu G, Saraswathi NK, Chandy M, Godec MS, Jacob
John T, Yanagihara R. Journal of General Virology.1993,74:2799-2805.
21. In vitro evaluation of newer beta lactam antibiotoics against gram negative bacilli isolated from
neutropaenic patients.Ebenezer S, Lalitha MK, Jesudason MV, Chandy M. Indian Journal of
Cancer.
22. Selective decontamination of the digestive tract with Ofloxacin.
Ramanathan M, Chandy M, Lalitha MK. submitted Indian Journal of Cancer.
23. Kudva G, Chandy M, Dennison D, Srivastava A, Bhushan V. .Treatment of acute lymphoblastic
leukaemia in adults with modified BFM regimen. Ind J Cancer.1994,31: 1-7.
24. Kudva G, Chandy M, Raghupathy P, Dennison D, Srivastava A, Bhushan V, Singh R. Treatment
of childhood acute lymphoblastc leukaemia with BFM regimen. Ind J Cancer. 1994, 31: 78-75.
25. Bhushan V, Chandy M, Babu GP, Dennison D, Srivastava A, Saraswathi NK, Jacob John T.
Transfusion associated HIV infection in patients with haematologic disorders in southern India.
Ind Jr Med Res 1994, 99: 57-60
26. Bhushan V, Chandy M, Khanduri U, Dennison D, Srivastava A, Apte S. Surgery in patients with
congenital coagulation disorders. Natl Med J Ind 1994, 7: 8-12.
27. Poonkuzhli B, Victoria J, Selvakumar R, Dennison D, Srivastava A, Jeyaseelan L, Chandy M,
Kanagasabapathy AS. Comparison of HPLC and EMIT methods of Cyclosporine assay in blood
after bone marrow transplantation. Ind Jr Med Res 1995, 102: 39-41.
28. Ramani P, Krishnaswami H, Srivastava A, Dennison D, Chandy M. Infections in bone marrow
transplant recipients in South India - a post mortem study.
Jr Trop Med Hyg 1994,97: 354356.

29. Dennison D, Srivastava A, Chandy M, Jasper P, Korula G, Nair A. Elective caesarian splenectomy
in the management of chronic idiopathic thrombocytopenia in pregnancy. Blood 1989,74
(suppl 1): 1527
30. Chandy M, Khanduri U, Dennison D. Developing Hemophilia services in India. Southeast Asian J
Trop Med and Pub Health 1993,24 (suppl1): 66-68.
31. Bhave A, Chandy M, Jacob John T, Sudarsanam A, Christopher S and Dennison D.
Cytomegalovirus (CMV) Mononucleosis Syndrome. Ind J Pediatr 1994, 61: 584-585.
32. Chandy M. Management of haemophilia in developing countries with available resources.
Haemophilia 1995, 1 (suppl.1), 44-48.
33. Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bachkov NP, Boulyjenkov V, Chandy M,
Dahlback B, Ginter EK, Miletich JP, Rosendaal FR, Seligsohn U. Inherited Thrombophilia : Part I
Thrombosis and Haemostasis 1996,76(5) 651-62.
34. Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bachkov NP, Boulyjenkov V, Chandy M,
Dahlback B, Ginter EK, Miletich JP, Rosendaal FR, Seligsohn U. Inherited Thrombophilia : Part II
Thrombosis and Haemostasis 1996,76(6) 824-34.
35. Chandy M, Bradstock KF, Srivastava A, Apte S. Treatment of severe aplastic anaemia with anti
T-cell monoclonal antibody (WM48). Blood 1994,81[suppl 1]:9.
36. Quernin MH, Poonkuzhali B, Montes C, Krishnamoorthy R, Dennison D, Srivastava A, Vilmer E,
Chandy M, Jacqz-Aigrain E. Quantification of busulfan in plasma by gas chromatography-mass
spectrometry following derivatization with tetrafluorothiophenol. J Chromatography B,709
(1998) 47- 56
37. Transvaginal Chorionic Villus Sampling an Alternative Approach. Goeorge K, George SS,
Janes C, Fernandez HA, Shaji RV, Srivastava A, Chandy M. Aust NZ Obstet Gynaecol 1999:4:
489-491.
38. Poonkuzhali B, Srivastava A, Quernin MH, Dennison D, Aigrain EJ, Kanagasabapathy AS,
Krishnamoorthy R, Chandy M Pharmacokinetics of oral busulphan in children with beta
thalassaemia major undergoing allogeneic bone marrow transplantation.. Bone Marrow
Transplantation 1999; 24, 5-11.
39. Successful Bone Marrow Transplantation in an Infant with Wiskott-Aldrich Syndrome
Mathew JG, Chandy M, Dennison D, Srivastava A, Ganapathy K, Cherian T. Indian Pediatrics
(1999) 36: 707-710.

40. Evaluation of uroprotective efficacy of amifostine against cyclophosphamide induced

hemorrhagic cystitis. Srivastava A, Nair SC, Srivastava VM, Balamurugan AN, Jeyaseelan L,
Chandy M and Gunasekaran S. Bone Marrow Transplantation 1999; 23: 463-467.
41. High-performance liquid chromatographic method for quantification of busulfan in plasma
after derivatization by tetrafluorothiophenol. MH.Quernin, B.Poonkuzhali, Y.Medard,
D.Dennison, A.Srivastava, R.Krishnamoorthy, M.Chandy & EJ Aigrain. J Chromatogr 1999;
721: 147-152.
42. Prevalence of Factor V G 1691 A mutation and prothrombin variant G20210 A in India.
A.Srivastava, NEJ Remington, RV.Shaji, M.Chandy. Thromb Haemost (Suppl 73)1999; 219a.
43. Role of Arsenic trioxide in the management of APML. V Mathews, Srivastava A, Biju George,
Mammen Chandy. Ind J Hematol Blood Trans Dec 1999.
44. Fludarabine, busulfan and anti-thymocyte globulin conditioning for allogeneic bone marrow
transplantation for severe aplastic anaemia.Sharma A, Srivastava A, Mathews V, George B,
Chandy M. Ind J Haematol Blood Trans 1999; 17 (Suppl. 1):15.
45. A single tube multiplex PCR for detection of common + thalassaemia alleles. R.V.Shaji,
A.Srivastava, M.Chandy, R.Krishnamoorthy (letter) Blood 2000; 95;1879-1880.
46. Hemostasis with cryoprecipitate in patients undergoing surgery for severe von Willebrands
disease. V.Mathews , A Srivastava, SC Nair, M Chandy Natl Med J Ind 13: 188-190, 2000
47. M.Chandy. Autologous bone marrow transplantation. Natl Med J of India 2000; 13: 55-57.
48. B. Poonkuzhali, M. Chandy, A. Srivastav, D. Denniso, A.S. Kanagasabapathy, R.
Krishnamoorthy.Glutathione S-transferase levels influence busulfan pharmacokinetics in
patients with beta thalassemia major undergoing Bone Marrow Transplantation. Drug
Metab Dispos 2001; March; 29:
49. Poonkuzhali Balasubramanian, Alok Srivastava, & Mammen Chandy. Stability of busulfan in
frozen plasma and whole blood samples. Clin Chem 2001; April
50. V.Mathews, B.Poonkuzhali, Shaji R.V, B.George, M.Chandy & A.Srivastava. Central Nervous
system relapse in a patient with acute promyelocytic leukemia treated with arsenic trioxide.
British J Haematol (In press).
51. B. Poonkuzhali, M. Chandy, A. Srivastava, D. Dennison, R. Krishnamoorthy. Glutathione Stransferase levels influences busulfan pharmacokinetics in patients with beta thalassemia
major undergoing Bone Marrow Transplantation. Drug Metab Dispos 2001; 29: 264-267.

52. Poonkuzhali B, Srivastava A, & Chandy M. Stability of busulfan in frozen plasma and whole
blood samples. Clin Chem 2001; 47: 766-768.
53. V.Mathews, B.Poonkuzhali, Shaji R.V, B.George, M.Chandy & A.Srivastava. Central Nervous
system relapse in a patient with acute promyelocytic leukemia treated with arsenic trioxide.
Brit J Haematol 2001; 113: 257-258.
54. George B, Danda D, Mathews V, Srivastava A, Chandy M. Poliomyelitis: An unusual
manifestation of chronic graft vs host disease. Rheumatol Int 2001; 20: 169-170.
55. George B, Mathews V, Srivastava V, Srivastava A, Chandy M. Tuberculosis among allogeneic
bone marrow transplant recipients in India. Bone Marrow Transplant 2001; 27: 973-976.
56. Chandy M, Srivastava A, Dennison D, Mathews V, George B. Allogeneic bone marrow
transplantation in the developing world: experience from a center in India. Bone Marrow
Transplant 2001; 27: 785-790.
57. Mathews V, Chandy M, Srivastava A. Arsenic trioxide in the management of acute
promyelocytic leukemia. Natl Med J India 2001; 14: 215-222.
58. Shaji R.V, Srivastava A, Krishnamoorthy R, Chandy M. A novel beta thalassaemia mutation in
an Asian Indian. Haemoglobin 2001 (In Press).
59. Poonkuzhali B, Chandy M, Krishnamoorthy R, Srivastava A. Evaluation of existing limited
sampling models for busulfan kinetics in children with beta thalassaemia major undergoing
bone marrow transplantation. Bone Marrow Transplant 2001 Nov;28 (9):821-5.
60. Simon A, Pillai S, Raghupathy P, Chandy M. Leucocyte adhesion deficiency-1.
Indian Pediatr. 2002 Oct;39(10):963-6.
61. Shaji RV, Srivastava A, Krishnamoorthy R, Chandy M. Coexistence of a novel beta-globin
gene deletion (codons 81-87) with the codon 30 (G-->C) mutation in an Indian patient with
beta0-thalassemia.Hemoglobin. 2002 Aug; 26(3):237-43.
62. Shivakumara S, Mathew S, Dalton J, Chandy M, Srivastava A.
A complex karyotype involving chromosomes 3, 6, 11, 12, and 22 in adult acute
lymphoblastic leukemia.Leuk Lymphoma. 2002 Aug; 43(8):1673-7.
63. Mathews V, Balasubramanian P, Shaji RV, George B, Chandy M, Srivastava A. Arsenic
trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: a single center
experience.Am J Hematol. 2002 Aug;70 (4):292-9.
64. Shivakumar S, Poonkhuzhali B, Gunasekaran S, Srivastava A, Chandy M.

Cytogenetic, fluorescent in situ hybridization & reverse transcriptase-polymerase chain

reaction analysis in acute promyelocytic leukaemia patients.Indian J Med Res. 2002
Feb;115:59-67.
65. Vezhappilly Kunjali Naina H, Nair SC, Daniel D, George B, Chandy M.
Asymptomatic constitutional macrothrombocytopenia among West Bengal blood donors.
Am J Med. 2002 Jun 15;112(9):742-3.
66. Chandy M. Ethics of haemophilia care in the developing world.
Haemophilia. 2002 May;8(3):439-40.

67. Kang G, Srivastava A, Pulimood AB, Dennison D, Chandy M.

Etiology of diarrhea in patients undergoing allogeneic bone marrow transplantation in
South India.Transplantation. 2002 Apr 27;73(8):1247-51.
68. Shaji RV, Gerard N, Krishnamoorthy R, Srivastava A, Chandy M.
A novel beta-thalassemia mutation in an Asian Indian.
Hemoglobin. 2002 Feb;26(1):49-57.
69. Srivastava A, Mathews V, Bhurani D, Baidya S, Chandy M.
Successful surgical hemostasis in patients with von Willebrand disease following infusion of
Koate DVI. Thromb Haemost. 2002 Mar;87(3):541-3.
70. George B, Mathews V, Srivastava A, Chandy M. Infections among allogeneic bone marrow
transplant recipients in India. Bone Marrow Transplant. 2003 Dec 1
71. Shaji RV, Eunice SE, Baidya S, Srivastava A, Chandy M. Determination of the breakpoint and
molecular diagnosis of a common alpha-thalassaemia-1 deletion in the Indian population. Br
J Haematol. 2003 Dec;123(5):942-7.
72. Srivastava A, Usher S, Nelson EJ, Jayandharan G, Shaji RV, Chandy M, Seligsohn U, Peretz H.
Prenatal diagnosis of Glanzmann thrombasthenia. Natl Med J India. 2003 Jul-Aug;16(4):2078.
73. Jayandharan G, Shaji RV, Chandy M, Srivastava A.
Identification of factor IX gene defects using a multiplex PCR and CSGE strategy-a first
report.J Thromb Haemost. 2003 Sep;1(9):2051-4
74. Shaji RV, Edison ES, Poonkuzhali B, Srivastava A, Chandy M. Rapid detection of beta-globin
gene mutations and polymorphisms by temporal temperature gradient gel electrophoresis.
Clin Chem. 2003 May;49(5):777-81.

75. Shaji RV, Edison ES, Krishnamoorthy R, Chandy M, Srivastava A. Hb Lepore in the Indian
population. Hemoglobin. 2003 Feb;27(1):7-14.
76. George B, Mathews V, Srivastava A, Chandy M. Infections among allogeneic bone marrow
transplant recipients in India.Bone Marrow Transplant. 2004 Feb;33(3):311-5.
77. George B, Mathews L, Balasubramanian P, Shaji RV, Srivastava A, Chandy M. Molecular
remission with arsenic trioxide in patients with newly diagnosed acute promyelocytic
leukemia. Haematologica. 2004 Oct;89(10):1266-7.
78. George B, Mathews V, Poonkuzhali B, Shaji RV, Srivastava A, Chandy M. Treatment of
children with newly diagnosed acute promyelocytic leukemia with arsenic trioxide: a single
center experience. Leukemia. 2004 Oct;18(10):1587-90.

79. Lee V, Srivastava A, PalaniKumar C, Daniel AJ, Mathews V, Babu N, Chandy M,

Sundararaj GD. External fixators in haemophilia. Haemophilia. 2004 Jan;10(1):52-7.
80. Srivastava A, Poonkuzhali B, Shaji RV, George B, Mathews V, Chandy M,
Krishnamoorthy R. Glutathione S-Transferase M1 Polymorphism- A Risk Factor for
Hepatic Venoocclusive Disease In Bone Marrow Transplantation. Blood. 2004 Sep
1;104(5):1574-7.
81. Eapen CE, Santhosh S, Shaji RV, Chandy M, Chandy GM. Gene symbol: ATP7B.Disease:
Wilson's disease. Hum Genet. 2004 May;114(6):606.
82. Jayandharan G, Shaji RV, George B, Chandy M, Srivastava A. Informativeness of linkage
analysis for genetic diagnosis of haemophilia A in India. Haemophilia. 2004 Sep;10(5):553-9.
83. Damodar S, Viswabandya A, George B, Mathews V, Chandy M, Srivastava A. Dapsone for
chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90
patients. Eur J Haematol. 2005 Oct; 75(4):328-31.
84. Edison ES, Shaji RV, Srivastava A, Chandy M. Compound heterozygosity for Hb E and Hb
Lepore-Hollandia in India; first report and potential diagnostic pitfalls.
Hemoglobin. 2005;29(3):221-4.

85. Edison ES, Shaji RV, Srivastava A, Chandy M. Hyperbilirubinemia in homozygous HbE
disease is associated with the UGT1A1 gene polymorphism. Hemoglobin. 2005;29(3):18995.

86. Edison ES, Shaji RV, Devi SG, Kumar SS, Srivastava A, Chandy M. Hb Showa-Yakushiji
[beta110(G12)Leu-->Pro] in four unrelated patients from west Bengal. Hemoglobin.
2005;29(1):19-25.
87. Chandy M, Balasubramanian P, Ramachandran SV, Mathews V, George B, Dennison D,
Krishnamoorthy R, Srivastava A. Randomized trial of two different conditioning regimens
for bone marrow transplantation in thalassemia - the role of busulfan pharmacokinetics in
determining outcome. Bone Marrow Transplant. 2005 Sep 5; 1-7.
88. Jayandharan G, Shaji RV, Baidya S, Nair SC, Chandy M, Srivastava A. Identification of factor
VIII gene mutations in 101 patients with haemophilia A: mutation analysis by inversion
screening and multiplex PCR and CSGE and molecular modelling of 10 novel missense
substitutions. Haemophilia. 2005 Sep;11(5):481-91.
89. Damodar S, George B, Mammen J, Mathews V, Srivastava A, Chandy M. Pre-transplant
reduction of isohaemagglutinin titres by donor group plasma infusion does not reduce the
incidence of pure red cell aplasia in major ABO-mismatched transplants. Bone Marrow
Transplant. 2005 Aug;36(3):233-5.
90. Jayandharan G, Viswabandya A, Baidya S, Nair SC, Shaji RV, George B, Chandy M, Srivastava
A. Six novel mutations including triple heterozygosity for Phe31Ser, 514delT and 516T-->G
factor X gene mutations are responsible for congenital factor X deficiency in patients of
Nepali and Indian origin. J Thromb Haemost. 2005 Jul;3(7):1482-7.
91. Jayandharan G, Viswabandya A, Baidya S, Nair SC, Shaji RV, Chandy M, Srivastava A.
Molecular genetics of hereditary prothrombin deficiency in Indian patients: identification of
a novel Ala362 --> Thr (Prothrombin Vellore 1) mutation. J Thromb Haemost. 2005
Jul;3(7):1446-53.
92. Jayandharan G, Shaji RV, Nair SC, Chandy M, Srivastava A. Novel missense mutations in two
patients with factor XI deficiency (Val271Leu and Tyr351Ser) and one patient with combined
factor XI and factor IX deficiency (Phe349Val). J Thromb Haemost. 2005 Apr;3(4):808-11.
93. George B, Mathews V, Shaji RV, Srivastava V, Srivastava A, Chandy M. Fludarabine-based
conditioning for allogeneic stem cell transplantation for multiply transfused patients with
Fanconi's anemia. Bone Marrow Transplant. 2005 Feb; 35(4):341-3.
94. George B, Poonkuzhali B, Srivastava VM, Chandy M, Srivastava A. Hematological and
molecular remission with combination chemotherapy in a patient with PLZF-RARalpha acute
promyelocytic leukemia (APML). Ann Hematol. 2005 Jun;84(6):406-8.
95. Edison ES, Melinkeri SR, Chandy M. A novel missense mutation in glucose-6-phosphate
dehydrogenase gene causing chronic nonspherocytic hemolytic anemia in an Indian
family.Ann Hematol. 2006 Aug 31;

96. Nelson EJ, Nair SC, Peretz H, Coller BS, Seligsohn U, Chandy M, Srivastava A. Diversity of
Glanzmann thrombasthenia in southern India: 10 novel mutations identified among 15
unrelated patients. J Thromb Haemost. 2006 Aug;4(8):1730-7.
97. Chandy M. An approach to the management of leukemia in the developing world. Clin Lab
Haematol. 2006 Jun;28(3):147-53.
98. Deotare UR, Vishwabandya A, Mathews V, George B, Srivastava A, Chandy M. Response to
high-dose dexamethasone for acquired pure red cell aplasia following ABO-mismatched
allogeneic stem cell transplantation. Bone Marrow Transplant. 2006 Jun;37(12):1149-50.
99. Peyvandi F, Jayandharan G, Chandy M, Srivastava A, Nakaya SM, Johnson MJ, Thompson
AR, Goodeve A, Garagiola I, Lavoretano S, Menegatti M, Palla R, Spreafico M, Tagliabue L,
Asselta R, Duga S, Mannucci PM. Genetic diagnosis of haemophilia and other inherited
bleeding disorders. Haemophilia. 2006 Jul;12 Suppl 3:82-9.
100. Jayandharan GR, Viswabandya A, Baidya S, Nair SC, George B, Mathews V, Chandy M,
Srivastava A. Mutations in coagulation factor XIII A gene in eight unrelated Indians. Five
novel mutations identified by a novel PCR-CSGE approach. Thromb Haemost. 2006
Mar;95(3):551-6.
101. Mathews V, Desire S, George B, Lakshmi KM, Rao JG, Viswabandya A, Bajel A, Srivastava
VM, Srivastava A, Chandy M. Hepatotoxicity profile of single agent arsenic trioxide in the
treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome
and the effect of genetic polymorphisms on the incidence of hepatotoxicity. Leukemia. 2006
May;20(5):881-3.
102. Sellathamby S, Balasubramanian P, Sivalingam S, Shaji RV, Mathews V, George B,
Viswabandya A, Srivastava A, Chandy M. Developing an algorithm of informative markers
for evaluation of chimerism after allogeneic bone marrow transplantation. Bone Marrow
Transplant. 2006 Apr;37(8):751-5.
103. George B, Mathews V, Viswabandya A, Srivastava A, Chandy M. Infections in children
undergoing allogeneic bone marrow transplantation in India. Pediatr Transplant. 2006
Feb;10(1):48-54.
104. Peretz H, Rosenberg N, Landau M, Usher S, Nelson EJ, Mor-Cohen R, French DL, Mitchell
BW, Nair SC, Chandy M, Coller BS, Srivastava A, Seligsohn U. Molecular diversity of
Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and
structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3). Hum Mutat. 2006
Apr;27(4):359-69.

105. Nelson EJ, Li J, Mitchell WB, Chandy M, Srivastava A, Coller BS. Three novel betapropeller mutations causing Glanzmann thrombasthenia result in production of normally
stable pro-alphaIIb, but variably impaired progression of pro-alphaIIbbeta3 from
endoplasmic reticulum to Golgi. J Thromb Haemost. 2005 Dec;3(12):2773-83.
106. Mathews V, George B, Lakshmi KM, Viswabandya A, Bajel A, Balasubramanian P, Shaji
RV, Srivastava VM, Srivastava A, Chandy M. Single-agent arsenic trioxide in the treatment
of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity.
Blood. 2006 Apr 1;107(7):2627-32.
107. Mathews V, George B, Deotare U, Lakshmi KM, Viswabandya A, Daniel D, Chandy M,
Srivastava A. A new stratification strategy that identifies a subset of class III patients with an
adverse prognosis among children with beta thalassemia major undergoing a matched
related allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2007
Aug;13(8):889-94.
108. Jayandharan G, Spreafico M, Viswabandya A, Chandy M, Srivastava A, Peyvandi F.
Mutations in the MCFD2 gene are predominant among patients with hereditary combined
FV and FVIII deficiency (F5F8D) in India. Haemophilia. 2007 Jul;13(4):413-9.
109. Lee VN, Srivastava A, Nithyananth M, Kumar P, Cherian VM, Viswabandya A, Mathews V,
George B, Venkatesh K, Nair SC, Chandy M, Sundararaj GD. Fracture neck of femur in
haemophilia A - experience from a cohort of 11 patients from a tertiary centre in India.
Haemophilia. 2007 Jul;13(4):391-4.
110. Jayandharan GR, Viswabandya A, Nair SC, Chandy M, Srivastava A. Molecular basis of
hereditary factor VII deficiency in India: five novel mutations including a double missense
mutation (Ala191Glu; Trp364Cys) in 11 unrelated patients. Haematologica. 2007
Jul;92(7):1002-3.
111. Mathews V, Thomas M, Srivastava VM, George B, Srivastava A, Chandy M.
Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with
newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic trioxide
regimen. Haematologica. 2007 Jul;92(7):994-5.
112. Bajel A, George B, Mathews V, Viswabandya A, Kavitha ML, Srivastava A, Chandy M.
Adult ALL: treatment outcome and prognostic factors in an Indian population using a modified
German ALL (GMALL) protocol. Leukemia. 2007 Oct;21(10):2230-3.
113. George B, Mathews V, Viswabandya A, Kavitha ML, Srivastava A, Chandy M.
Fludarabine and cyclophosphamide based reduced intensity conditioning (RIC) regimens
reduce rejection and improve outcome in Indian patients undergoing allogeneic stem cell
transplantation for severe aplastic anemia. Bone Marrow Transplant. 2007 Jul;40(1):13-8.

114. Sundaresan S, Eapen CE, Shaji RV, Chandy M, Kurian G, Chandy G. Screening for
mutations in ATP7B gene using conformation-sensitive gel electrophoresis in a family with
Wilson's disease. Med Sci Monit. 2007 Mar;13(3):CS38-40.
115. Santhosh S, Shaji RV, Eapen CE, Jayanthi V, Malathi S, Chandy M, Stanley M, Selvi S,
Kurian G, Chandy GM. ATP7B mutations in families in a predominantly Southern Indian
cohort of Wilson's disease patients. Indian J Gastroenterol. 2006 Nov-Dec;25(6):277-82.
116. Subramaniam K, George B, Mathews V, Viswabandya A, Srivastava A, Chandy M. Salvage
with a mini-allograft after primary engraftment failure following autologous transplant for
multiple myeloma. Bone Marrow Transplant. 2007 Feb;39(4):239-40.
117. Chandy M. Stem cell transplantation in India. Bone Marrow Transplant. 2008 Aug;42
Suppl 1:S81-S84.
118. Edison ES, Bajel A, Chandy M. Iron homeostasis: new players, newer insights. Eur J
Haematol. 2008 Dec;81(6):411-24.
119. Santhosh S, Shaji RV, Eapen CE, Jayanthi V, Malathi S, Finny P, Thomas N, Chandy M,
Kurian G, Chandy GM. Genotype phenotype correlation in Wilson's disease within families-a report on four south Indian families. World J Gastroenterol. 2008 Aug 7;14(29):4672-6.
120. Bajel A, George B, Mathews V, Viswabandya A, Kavitha ML, Srivastava A, Chandy M.
Treatment of children with acute lymphoblastic leukemia in India using a BFM protocol.
Pediatr Blood Cancer. 2008 Nov;51(5):621-5.
121. Mathews V, George B, Lakshmi KM, Viswabandya A, John JM, Sitaram U, Daniel D,
Chandy M, Srivastava A. : Impact of pretransplant splenectomy on patients with betathalassemia major undergoing a matched-related allogeneic stem cell transplantation.
Pediatr Transplant. 2008 May 14.
122. Viswabandya A, Mathews V, George B, Nair SC, Baidya S, Mammen JJ, Chandy M,
Srivastava A. Successful surgical haemostasis in patients with von Willebrand disease with
Koate((R))DVI. Haemophilia. 2008 Apr 27.
123. Edison ES, Shaji RV, Devi SG, Moses A, Viswabandhya A, Mathews V, George B,
Srivastava A, Chandy M. Analysis of beta globin mutations in the Indian population:
presence of rare and novel mutations and region-wise heterogeneity. Clin Genet. 2008
Apr;73(4):331-7..
124. Rajasekar R, Mathews V, Lakshmi KM, Sellathamby S, George B, Viswabandya A, Daniel
D, Chandy M, Srivastava A. Plasmacytoid dendritic cell count on day 28 in HLA-matched
related allogeneic peripheral blood stem cell transplant predicts the incidence of acute and
chronic GVHD. Biol Blood Marrow Transplant. 2008 Mar;14(3):344-50.

125. George B, Mathews V, Viswabandya A, Kavitha ML, Srivastava A, Chandy M. Fludarabine

based reduced intensity conditioning regimens in children undergoing allogeneic stem cell
transplantation for severe aplastic anemia.Pediatr Transplant. 2008 Feb;12(1):14-9.
126. Markose P, Chendamarai E, Balasubramanian P, Velayudhan SR, Srivastava VM,
Mathews V, George B, Viswabandya A, Srivastava A, Chandy M. Spectrum of BCR-ABL kinase
domain mutations in patients with chronic myeloid leukemia from India with suspected
resistance to imatinib-mutations are rare and have different distributions. Leuk Lymphoma.
2009 Dec;50(12):2092-5.
127. Desire S, Balasubramanian P, Bajel A, George B, Viswabandya A, Mathews V, Srivastava
A, Chandy M. Frequency of TPMT alleles in Indian patients with acute lymphatic leukemia
and effect on the dose of 6-mercaptopurine. Med Oncol. 2009 Oct 15.
128. Thirugnanam R, George B, Chendamarai E, Lakshmi KM, Balasubramanian P,
Viswabandya A, Srivastava A, Chandy M, Mathews V. .Comparison of clinical outcomes of
patients with relapsed acute promyelocytic leukemia induced with arsenic trioxide and
consolidated with either an autologous stem cell transplant or an arsenic trioxide-based
regimen. Biol Blood Marrow Transplant. 2009 Nov;15(11):1479-84.
129. Edison ES, Athiyarath R, Rajasekar T, Westerman M, Srivastava A, Chandy M. A novel
splice site mutation c.2278 (-1) G>C in the TMPRSS6 gene causes deletion of the substrate
binding site of the serine protease resulting in refractory iron deficiency anaemia. Br J
Haematol. 2009 Dec;147(5):766-9.
130. Jayandharan GR, Nair SC, Poonnoose PM, Thomas R, John J, Keshav SK, Cherian RS,
Devadarishini M, Lakshmi KM, Shaji RV, Viswabandya A, George B, Mathews V, Chandy M,
Srivastava A.Polymorphism in factor VII gene modifies phenotype of severe haemophilia.
Haemophilia. 2009 Nov;15(6):1228-36.
131. Rajasekar R, Mathews V, Lakshmi KM, George B, Viswabandya A, Chandy M, Srivastava
A. Cellular immune reconstitution and its impact on clinical outcome in children with beta
thalassemia major undergoing a matched related myeloablative allogeneic bone marrow
transplant. Biol Blood Marrow Transplant. 2009 May;15(5):597-609.
132. George B, Mathews V, Viswabandya A, Srivastava A, Chandy M. 8.Fludarabine-based
reduced intensity conditioning regimens for allogeneic hematopoietic stem cell
transplantation in patients with aplastic anemia and fungal infections Clin Transplant. 2009
Mar;23(2):228-32
133. Chandy M. .Innovative supportive care practices for stem cell transplantation in India.
Biol Blood Marrow Transplant. 2009 Jan;15(1 Suppl):95-8.

134. George B, Mathews V, Viswabandya A, Lakshmi KM, Srivastava A, Chandy M. Allogeneic

hematopoietic stem cell transplantation is superior to immunosuppressive therapy in Indian
children with aplastic anemia--a single-center analysis of 100 patients Pediatr Hematol
Oncol. 2010 Mar;27(2):122-31.
135. Rajasekar R, Lakshmi KM, George B, Viswabandya A, Thirugnanam R, Abraham A,
Chandy M, Srivastava A, Mathews V. Dendritic cell count in the graft predicts relapse in
patients with hematological malignancies undergoing a HLA-matched related allogeneic
peripheral blood stem cell transplant. Biol Blood Marrow Transplant. 2010.

Awards:
Kutumbiah Gold medal in Medicine.
John S Carman medal in Surgery.
TCF medal in Paediatrics.
Ida Scudder medal in Obstetrics and Gynaecology.
Medal for the best outgoing student.CMC,Vellore.
University medal for the first rank in MBBS 1971.
University Medal for the first rank in MD 1978
Manorama Sapre Oration, Indian Society of Haematology and Blood Transfusion, Bombay
1993.
Bhatia Oration, Institute of Immunohaematology, Bombay 1997.
Dr B.N.Dara Award for outstanding contribution to Thalassaemia in India, Delhi 1997.
Ranbaxy Research Award 2003 in the field of Medical Science Clinical Research
Arosenius Lecture Ethics of Hemophilia Care Finland 2004
Indian Doctors Forum-Kuwait Medical Association Oration 2006
Best Clinical Teacher Award. Christian Medical College Vellore. 2006