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Rev.

001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

APACHE IV Calculations
31TRGEXT000013

INSTRUCTIONS

To Calculate APS Score:

Following the methodology precisely, determine


the physiological variable furthest from the
reference point, whether higher or lower/above
or below. Assign APS points to that single, most
deviant value.
Resources for the correct collection of data
elements:
1. Knaus WA, Wagner DP, Draper EA,
Zimmerman JE. The APACHE III prognostic
system: risk prediction of hospital mortality for
critically ill hospitalized adults. Chest 1991;
100:1619-1636.
2. http://train.apacheweb.com/apacheIIIwebcourse/courselogin/login.
cfm
The accuracy of APACHE predictions is
dependent upon the quality of data upon which
predictions are made. Deviations from the
precise data collection methodology may result
in errors in prediction which Cerner Corporation
cannot be responsible for.

To determine disease category

Using the disease mapping table, select the


single primary reason for ICU admission.
Patients coming to the ICU from the operating
room or post-anesthesia care unit must be
assigned surgical diagnoses. ALL OTHER
PATIENTS will receive a non-operative
diagnosis.
Diseases are categorized by body system, and
then into operative and non-operative
categories for ease of use of this table.

Tab 1, p. 1 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

APACHE IV Calculations
31TRGEXT000013

Determine the disease category associated with


the ICU admitting diagnosis.

To calculate hospital mortality and/or ICU length


of stay

First, select the appropriate worksheet for the


prediction required and the patient (CABG,
Non-CABG) type
Enter the required values or use 1=yes,
blank=no.
For each set of variables, the options within
each color block are mutually exclusive. Select
only one of the options as a "yes" (1), the rest
"no" (0) or blank. More than one selection from
a single group will result in an error message.
Example: If disease category is SCAROTID=1,
all other disease categories=blank.

Additional Notes

Error messages will appear in red if more than


one mutually exclusive variable is selected.
All cells except those that accept data for the
calculations are "locked".

Tab 1, p. 2 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

Tab 2, p. 3 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013

Step 1: Calculate Acute Physiology Score


follows, entering the appropriate point value in the blue box to the right of each category:
Pulse (beats/min)
Select heart rate furthest from 75

<=39
40-49
50-99
100-109
110-119
120-139
140-154
>=155

8
5
0
1
5
7
13
17

Pulse points

Mean Blood Pressure (MAP)


Select MAP furthest from 90

<=39
40-59
60-69
70-79
80-99
100-119
120-129
130-139
>=140

23
15
7
6
0
4
7
9
10

MAP points

<=32.9
33-33.4
33.5-33.9
34-34.9
35-35.9
36-39.9
>=40

20
16
13
8
2
0
4

Temperature points

Respiratory Rate (breaths/min)*


Select respiratory rate furthest from 19
*for patients who are ventilated
no points are given for respiratory
rates of 6-12.

<=5
6-11
12-13
14-24
25-34
35-39
40-49
>=50

17
8
7
0
6
9
11
18

Respiratory rate points

PaO2 (mmHg)*
*Use only for non-intubated patients or
intubated patients with FiO2 <0.5 (50%).

<=49
50-69
70-79
>=80

15
5
2
0

PaO2 points

Temperature (degrees Centigrade)


Select core temperature furthest from 38.
Add 1 degree Centigrade to axillary temps
prior to selecting worst value

OR

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

Tab 2, p. 4 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013
OR

A-aDO2*
*Only use A-aDO2 for intubated patients
with FiO2 >=0.5 (50%). Do not use PaO2
weights for these patients.

<100
100-249
250-349
350-499
>=500

0
7
9
11
14

<=40.9
41-49
>=50

3
0
3

WBC (cu/mm)
Select WBC furthest from 11.5.

<1.0
1.0-2.9
3.0-19.9
20-24.9
>=25

19
5
0
1
5

Creatinine without ARF* (mg/dl)


Select creatinine furthest from 1.0.

<=0.4
0.5-1.4
1.5-1.94
>=1.95

3
0
4
7

0-1.4
>=1.5

0
10

Creatinine with ARF points

<=399
400-599
600-899
900-1499
1500-1999
2000-3999
>=4000

15
8
7
5
4
0
1

Urine output points

<=16.9
17-19
20-39
40-79
>=80

0
2
7
11
12

BUN points

<=119

Hematocrit (%)
Select hematocrit furthest from 45.5.

OR
Creatinine with ARF* (mg/dl)
*Acute Renal Failure (ARF) is defined as creatinine >=1.5 mg/dl
as creatinine >=1.5 mg/dl
and urine output <410 cc/day and no
chronic dialysis
Urine Output (cc/day)
Enter total for day

BUN (mg/dl)
Select highest BUN (furthest from 0)

Sodium (mEq/L)

A-aDO2 points

Hematocrit points

WBC points

Creatinine without ARF points

OR

Sodium points

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
Select Sodium furthest from 145.5.

Tab 2, p. 5 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
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120-134
135-154
>=155

2
0
4

Albumin (g/dl)
Select albumin furthest from 3.5.

<=1.9
2.0-2.4
2.5-4.4
>=4.5

11
6
0
4

Albumin points

Bilirubin (mg/dl)
Select highest bilirubin (furthest from 0)

<=1.9
2.0-2.9
3.0-4.9
5.0-7.9
>=8.0

0
5
6
8
16

Bilirubin points

<=39
40-59
60-199
200-349
>=350

8
9
0
3
5

Glucose points

Glucose (mg/dl)*
Select glucose furthest from 130
*Glucose <=39 mg/dl is lower
weight than 40-59

Acid-Base points (see below)


GCS points (see below)

TOTAL APS Score


Acid-Base Abnormalities*
*Assign score based upon pH-pCO2
relationship

pCO2<25 25-<30
pH <7.15
7.15-<7.2
7.20-<7.25
7.25-<7.30
7.30-<7.35
7.35-<7.40
7.40-<7.45
7.45-<7.50
7.50-<7.55
7.55-<7.60
7.60-<7.65
>=7.65

30-<35

0
35-<40 40-<45 45-<50 50-<55 55-<60 >=60

12

9
0
5

Neurological Abnormalities*
*If a patient is anesthetized, under the influence of anesthesia, or totally paralyzed/sedated during the ENTIRE data collection period,
attempt to obtain a GCS from the twelve-hour period prior to ICU admission when GCS was able to be assessed. If no assessable GCS
is documented during that time period, zero points shhould be assigned. If unable to determine verbal score (due to intubation status or
similar barriers), use clinical judgement and assign Glasgow Verbal Score according to the following scale:

1
2

12

Rev. 001
APACHE IV Calculations
Eff. Date: June 17, 2005
31TRGEXT000013
*If a patient
is anesthetized,
Owner:
Critical
Outcomes under the influence of anesthesia, or totally paralyzed/sedated during the ENTIRE data collection period,
attempt to obtain a GCS from the twelve-hour period prior to ICU admission when GCS was able to be assessed. If no assessable GCS
is documented during that time period, zero points shhould be assigned. If unable to determine verbal score (due to intubation status or
similar barriers), use clinical judgement and assign Glasgow Verbal Score according to the following scale:
alert, oriented 5
confused 3
nonresponsive 1
If patient's eyes open spontaneously (4) or to
painful/verbal stimulation (2,3), use scale:

verbal
motor

Note: shaded areas represent unlikely clinical combinations. Placing a patient


in any of these cells should be done after careful confirmation of clinical
findings.

Tab 2, p. 6 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

inappropriate
words, incomp.
sounds (3,2) no response (1)

oriented,
converses (5)

confused conversation (4)

obeys verbal
commands
(6)

10

15

localizes
pain (5)

13

15

flexion
withdrawal/de
corticate
rigidity (4,3)

13

24

24

decerebrate
rigidity/no
response
(2,1)

13

29

29

inappropriate
words, incomp.
sounds (3,2) no response (1)

If patient's eyes do not open spontaneously


or to painful/verbal stimulation (1), use scale:

verbal
motor

Note: shaded areas represent extremely unlikely clinical combinations, and


should not be used. If these combinations are verified in a clinical setting, no
prediction should be generated for the patient.

obeys verbal
commands
(6)

16

localizes
pain (5)

16

oriented,
converses (5)

confused conversation (4)

flexion
withdrawal/de
corticate
rigidity (4,3)

24

33

decerebrate
rigidity/no
response (1)

29

48

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

Tab 3, p. 7 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

(Document title: APACHE IV Calculations)

APACHE III Calculations


31TRGEXT000013

The APACHE III Score is the sum of points assigned to Acute Physiology (the APS Score, Age, and Chronic Health.
The predictive models use each of these three components individually, as separate and distinct
variables. Therefore the APACHE III Score is not required for mortality prediction. However, some
may find it valuable for other purposes. Enter appropriate point values in the blue box to the right.
Fill in blue shaded areas to obtain APACHE III Score
Age of patient
Select one

Under age 16
<=44
45-59
60-64
65-69
70-74
75-84
>=85

Chronic Health Items present on admission


If more than one is present, apply
the one with highest point value.
Select for non-operative or
emergency surgical patients
only, otherwise 0

AIDS
Hepatic Failure
Lymphoma
Metastatic cancer
Leukemia/multiple myeloma
Immunosuppression
Cirrhosis
None/not available

Acute Physiology Score (from previous worksheet)

Points
do not score
0
5
11
13
16
17
24

Total age points:

Points

Total chronic health points


23
16
13
11
10
10
4
0

Total APS score

APACHE III Score


0

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
APACHE Disease
Mapping
AMI_ANT
AMI_INFLAT
AMI_NONQ
AMI_OTHER
CVOTH
MEDAORT
PERIART
CHESTPAIN
USTAANG
CARDARR
CARDIOMY
CVOTH
CHESTPAIN
CHESTPAIN
CHESTPAIN
CHESTPAIN
CHESTPAIN
CHFD
CVOTH
MULTRAUM
CVOTH
CVOTH
CVOTH
HEMORRHAE
HYPERT
HYPOVOLEM
CVOTH
CVOTH
CARDIOG
CVOTH
RHYTHM
RHYTHM
RHYTHM

APACHE IV Calculations
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Cardiovascular (CARDIOVASC)
Non-Operative

Infarction, acute myocardial (MI), ANTERIOR


Infarction, acute myocardial (MI), INFEROLATERAL
Infarction, acute myocardial (MI), NON Q Wave
Infarction, acute myocardial (MI), none of the above
Anaphylaxis
Aneurysm, dissecting aortic
Aneurysm/pseudoaneurysm, other
Angina, stable (asymp or stable pattern of symptoms w/meds)
Angina, unstable (angina interferes w/quality of life or meds are tolerated poorly)
Cardiac arrest (with or without respiratory arrest; for respiratory arrest see Respiratory System)
Cardiomyopathy
Cardiovascular medical, other
Chest pain, atypical (noncardiac chest pain)
Chest pain, epigastric
Chest pain, musculoskeletal
Chest pain, respiratory
Chest pain, unknown origin
CHF, congestive heart failure
Complications of previous open heart
Contusion, myocardial (include R/O)
Efffusion, pericardial
Endocarditis
Hematomas
Hemorrhage (for gastrointestinal bleeding GI-see GI system) (for trauma see Trauma)
Hypertension, uncontrolled (for cerebrovascular
Hypovolemia (including dehydration. Do NOT include shock states.)
MI admitted > 24hrs after onset of ischemia
Monitoring, hemodynamic (pre-operative evaluation)
Papillary muscle rupture
Pericarditis
Rhythm disturbance (atrial, supraventricular)
Rhythm disturbance (conduction defect)
Rhythm disturbance (ventricular)

Tab 4, P. 8 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
APACHE IV Calculations
Eff. Date: June 17, 2005
31TRGEXT000013
Owner: Critical Outcomes
SEPSISCUT
Sepsis, cutaneous/soft tissue
SEPSISGI
Sepsis, GI
SEPTICUT
Sepsis, gynecologic
SEPSISOTH
Sepsis, other
SEPSISPULM
Sepsis, pulmonary
SEPTICUT
Sepsis, renal/UTI (including bladder)
SEPSISUNK
Sepsis, unknown
CARDIOG
Shock, cardiogenic
CVOTH
Tamponade, pericardial
CVOTH
Thrombosis, vascular (deep vein)
PERIART
Thrombus,arterial
DRUGTOXIC
Toxicity, drug (i.e., beta blockers, calcium channel blockers, etc.)
CVOTH
Vascular medical, other
APACHE Disease
Mapping
SCARDOTH
SCARDOTH
SELAORT
SAORTDIS
SRUPAOR
SELAORT
SAORTDIS
SRUPAORT
SCARDOTH
SVALVE
SVALVE
SCARDOTH
SVHDCABG
SCABGVALV
SVHDCABG
SCABGVALV
SCABGVALV
SCABGVALV
SCARDOTH
SCARDOTH

Cardiovascular (CARDIOVASC)
Post-Operative
Ablation or mapping of cardiac conduction pathway
Aneurysm repair, ventricular
Aneurysm, abdominal aortic
Aneurysm, abdominal aortic; with dissection
Aneurysm, abdominal aortic; with rupture
Aneurysm, thoracic aortic
Aneurysm, thoracic aortic; with dissection
Aneurysm, thoracic aortic; with rupture
Aneurysms, repair of other (except ventricular)
Aortic and Mitral valve replacement
Aortic valve replacement (isolated)
Atrial Septal Defect (ASD) Repair
CABG redo with valve repair/replacement
CABG with aortic valve replacement
CABG with double valve repair/replacement
CABG with mitral valve repair
CABG with mitral valve replacement
CABG with pulmonic or tricuspid valve repair or replacement.
CABG, Minimally invasive; Mid-CABG
Cardiovascular surgery, other

Tab 4, P. 9 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
APACHE IV Calculations
Eff. Date: June 17, 2005
31TRGEXT000013
Owner: Critical Outcomes
Complications of prev. peripheral vasc. surgery,surgery for (i.e.ligation of bleeder, exploration
SCARDOTH
and evacuation of hematoma, debridement, pseudoaneurysms, clots, fistula, etc.)
Complications of previous open-heart surgery, surgery for (i.e. bleeding, infection,
SCARDOTH
mediastinal rewiring,leaking aortic graft etc.)
SCARDOTH
Congenital Defect Repair (Other)
SCARDOTH
Defibrillator, automatic implantable cardiac; insertion of
SPERISC
Dilatation (with general anesthesia)
SPERISC
Dilatation (without general anesthesia)
SPERISC
Embolectomy (with general anesthesia)
SPERISC
Embolectomy (without general anesthesia)
SCARDOTH
Endarterectomy (other vessels)
SCAROTID
Endarterectomy, carotid
SCARDOTH
Graft for dialysis, insertion of
SAGRAFT
Graft, aorto-femoral bypass
SAGRAFT
Graft, aorto-iliac bypass
SCARDOTH
Graft, femoral-femoral bypass
SFEMPGRAF
Graft, femoral-popliteal bypass
SPERISC
Grafts, all other bypass (except renal)
SPERISC
Grafts, all renal bypass
SCARDOTH
Grafts, removal of infected vascular
SVALVE
Mitral valve repair
SVALVE
Mitral valve replacement
SCARDOTH
Pericardial effusion/tamponade
SCARDOTH
Pericardiectomy (total/subtotal)
SVALVE
Pulmonary valve surgery
SPERISC
Thrombectomy (with general anesthesia)
SPERISC
Thrombectomy (without general anesthesia)
SVALVE
Tricuspid valve surgery
SCARDOTH
Tumor removal, intracardiac
SCARDOTH
Vascular surgery, other
SCARDOTH
Vena cava clipping
SCARDOTH
Vena cava filter insertion
SCARDOTH
Ventricular Septal Defect (VSD) Repair
APACHE Disease
Mapping
RENOTH

Genitourinary (GENITOURIN)
Non-Operative
Genitourinary medical, other

Tab 4, P. 10 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
CVOTH
Hemorrhage, postpartum (female only)
HEPATF
Hepato-renal syndrome
HYPERT
Pre-eclampsia/eclampsia (female only)
RENOTH
Renal bleeding
RENOTH
Renal failure, acute
RENOTH
Renal infection/abscess
RENOTH
Renal neoplasm, cancer
RENOTH
Renal obstruction
APACHE Disease
Mapping
SRENOTH
GENOTH
GENOTH
SRENOTH
SRENCA
GENOTH
GENOTH
GENOTH
GENOTH
SOBHYST
SOBHYST
GENOTH
GENOTH
GENOTH
SRENOTH
SRENCA
SRENCA
SRENOTH
SRENOTH
GENOTH
SRENOTH
GENOTH
SRENOTH
SRENCA
SRENOTH
SRENCA

APACHE IV Calculations
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Genitourinary (GENITOURIN)
Post-Operative
Bladder repair for perforation/rupture
Cesarean section
Cyst, ruptured ovarian
Cystectomy (other reasons)
Cystectomy for neoplasm
Ectopic pregnancy (all)
Exenteration, pelvic -male
Exenteration, pelvic-female
Genitourinary surgery, other
Hysterectomy for cancer with or without lymph node dissection
Hysterectomy for other benign neoplasm/fibroids
Lymph node dissection, pelvic or retroperitoneal(female)
Lymph node dissection, pelvic or retroperitoneal(male)
Mastectomy (all)
Nephrectomy (other reasons)
Nephrectomy for neoplasm
Obstruction due to neoplasm ,surgery for; (with or without ileal-conduit)
Obstruction due to nephrolithiasis, surgery for (with or without ileal-conduit)
Obstruction/other, surgery for (with or without ileal-conduit)
Oophorectomy with/without salpingectomy with/without lymph node dissection
Orchiectomy with/without pelvic lymph node dissection
Pelvic relaxation (cystocele, rectocele, etc.)
Prostatectomy, suprapubic; for benign prostatic hypertrophy
Prostatectomy, suprapubic; for cancer
TURP, transurethral prostate resection for benign prostatic hypertrophy
TURP, transurethral prostate resection for cancer

Tab 4, P. 11 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
APACHE Disease
Mapping
OD
GIBLVAR
GIBLEED
GIBLEUL
GIBLEED
GINEOP
GINEOP
GINEOP
GINEOP
GINEOP
GIINFLA
GIINFLA
HEPATF
GIINFLA
GIOTHER
GIOBSTR
GIPERF
GIVASC
PERITOHEM
HEPATF
GIINFLA
PANCRE
GIINFLA
GIOTHER
APACHE Disease
Mapping
SGIOTH
SGIBLEE
SGIBLEE
SGIBLEE
SGIBLEE
SGICA
SGICA
SGICA

APACHE IV Calculations
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Gastrointestinal (GI)
Non-Operative

Alcohol withdrawal
Bleeding, GI from esophageal varices/portal hpertension
Bleeding, GI-location unknown
Bleeding, lower GI
Bleeding, upper GI
Cancer, colon/rectal
Cancer, esophageal
Cancer, other GI
Cancer, pancreatic
Cancer, stomach
Cholangitis
Diverticular disease
Encephalopathy, hepatic
GI Abscess/cyst
GI medical, other
GI Obstruction
GI Perforation/rupture
GI Vascular insufficiency
Hemorrhage, intra/retroperitoneal
Hepatic failure, acute
Inflammatory bowel disease
Pancreatitis
Peritonitis
Ulcer disease, peptic
Gastrointestinal (GI)
Post-Operative
Appendectomy
Bleeding-lower GI, surgery for
Bleeding-other GI, surgery for
Bleeding-upper GI, surgery for
Bleeding-variceal, surgery for (excluding vascular shunting-see surgery for portosystemic shunt)
Cancer-colon/rectal, surgery for (including abdominoperineal resections)
Cancer-esophageal, surgery for (abdominal approach)
Cancer-other GI tract, surgery for (i.e. hepatoma, gallbladder etc.)

Tab 4, P. 12 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
Tab 4, P. 13 of 36
APACHE IV Calculations
Eff. Date: June 17, 2005
Reviewer: Fern Malila
31TRGEXT000013
Owner: Critical Outcomes
Approver: Kim Hlobik
SGICA
Cancer-small intestinal, surgery for
SGICA
Cancer-stomach, surgery for
SGIOTH
CAPD catheter insertion
SGICHOL
Cholecystectomy/cholangitis, surgery for (gallbladder removal)
SGIOTH
Complications of previous GI surgery; surgery for (anastomotic leak, bleeding, abscess, infection, dehiscence, etc.)
SGIINFL
Diverticular disease, surgery for
SGIOTH
Esophageal surgery, other
SGIABCES
Fistula/abscess, surgery for (not inflammatory bowel disease)
SGIOTH
Gastrostomy
SGIABCES
GI Abscess/cyst-primary, surgery for (for complications of GI surgery see below)
SGIOBS
GI Obstruction, surgery for (including lysis of adhesions)
SGIPERF
GI Perforation/rupture, surgery for
SGIOTH
GI surgery, other
SGIVASC
GI Vascular ischemia, surgery for (resection)
SGIOTH
Hernia-hiatal, esophageal surgery for
SGIOTH
Herniorrhaphy
SGIINFL
Inflammatory bowel disease, surgery for
SGIOTH
Obesity-morbid, surgery for
SGIOTH
Pancreatitis, surgery for
SGIOTH
Peritoneal lavage
SGIPERF
Peritonitis, surgery for
SGIOTH
Shunt, peritoneal-venous;surgery for
SGIOTH
Shunt-portosystemic, surgery for
SGIOTH
Splenectomy
SGICA
Whipple-surgery for pancreatic cancer
APACHE Disease
Mapping
HEMAMISC
HEMAMISC
COAGTHRO
HEMAMISC
HEMAMISC
HEMAMISC
HEMAMISC
HEMAMISC
HEMAMISC

Hematology (HEMATO)
Non-Operative
Anemia
Blood transfusion reaction
Coagulopathy
Hematologic medical, other
Leukemia, acute lymphocytic
Leukemia, acute myelocytic
Leukemia, chronic lymphocytic
Leukemia, chronic myelocytic
Leukemia, other

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
HEMAMISC
Lymphoma, Hodgkins
HEMAMISC
Lymphoma, non-Hodgkins
COAGTHRO
Neutropenia
COAGTHRO
Pancytopenia
HEMAMISC
Sickle cell crisis
COAGTHRO
Thrombocytopenia
APACHE Disease
Mapping
HEMAMISC
HEMAMISC
HEMAMISC
APACHE Disease
Mapping
ACIDBASE
METAMISC
GIOTHER
COMAMETU
DIABETIC
METAMISC
METAMISC
METAMISC
METAMISC
METAMISC
METAMISC
METAMISC
METAMISC
APACHE Disease
Mapping
HEMAMISC
HEMAMISC
HEMAMISC
HEMAMISC
HEMAMISC

APACHE IV Calculations
31TRGEXT000013

Hematology (HEMATO)
Post-Operative
Hematologic surgery, other
Lymphoma Hodgkins, surgery for (including staging)
Lymphoma, non-Hodgkins; surgery for (including staging)
Metabolic/Endocrine (METAB/ENDO)
Non-Operative
Acid-base electrolyte disturbance
Addisons disease
Adrenal neoplasm (including pheochromocytoma)
Diabetic hyperglycemic hyperosmolar nonketotic coma (HHNC)
Diabetic ketoacidosis
Heat exhaustion/stroke
Hyperthermia
Hyperthyroid storm/crisis
Hypoglycemia
Hypothermia
Hypothyroid/myxedema
Metabolic/endocrine medical, other
Thyroid neoplasm
Metabolic/Endocrine (METAB/ENDO)
Post-Operative
Adrenalectomy
Metabolic/endocrine surgery, other
Parathyroidectomy
Thyroidectomy and parathyroidectomy
Thyroidectomy

APACHE Disease
Mapping
GENOTH
Arthritis, rheumatoid

Musculoskeletal/Skin (MUSKELSKIN)
Non-Operative

Tab 4, P. 14 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
APACHE IV Calculations
Eff. Date: June 17, 2005
31TRGEXT000013
Owner: Critical Outcomes
GENOTH
Arthritis, septic
PERIART
Cellulitis and localized soft tissue infections
GENOTH
Connective tissue disease (mixed)
GENOTH
Lupus, systemic
GENOTH
Musculoskeletal medical, other
GENOTH
Myositis, viral
GENOTH
Rhabdomyolysis
GENOTH
Scleroderma
GENOTH
Vasculitis
APACHE Disease
Mapping
SAMPUTATE
SPERISC
GENOTH
GENOTH
GENOTH
GENOTH
GENOTH
GENOTH
GENOTH
APACHE Disease
Mapping
NEURINF
NEURMUS
COMAMETU
STROKE
OD
NEURINF
COMAMETU
NEURMUS
SAHMED
SAHMED
ICHMED
NEUROTH
NEURINF
NEURMUS

Tab 4, P. 15 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Musculoskeletal/Skin (MUSKELSKIN)
Post-Operative
Amputation (non-traumatic)
Cellulitis and localized soft tissue infections, surgery for
Cosmetic surgery (all)
Fracture-pathological, non-union, non-traumatic, for fractures due to trauma see Trauma
Grafting, skin (all)
Hip replacement, total (non-traumatic)
Knee replacement, total (non-traumatic)
Orthopedic surgery, other
Skin surgery, other
Neurologic (NEUROLOGIC)
Non-Operative
Abscess, neurologic
Amyotrophic lateral sclerosis
Coma/change in level of consciousness (for hepatic see GI, for diabetic see Endocrine, if related to cardiac arrest, see CV)
CVA, cerebrovascular accident/stroke
Drug withdrawal
Encephalitis
Encephalopathies (excluding hepatic)
Guillian-Barre syndrome
Hematoma, epidural
Hematoma, subdural
Hemorrhage/hematoma, intracranial
Hydrocephalus, obstructive
Meningitis
Myasthenia gravis

Rev. 001
APACHE IV Calculations
Eff. Date: June 17, 2005
31TRGEXT000013
Owner: Critical Outcomes
NEONEUR
Neoplasm, neurologic
NEUROTH
Neurologic medical, other
NEURMUS
Neuromuscular medical, other
CARDARR
Nontraumatic coma due to anoxia/ischemia
OD
Overdose, alcohols (bethanol, methanol, ethylene glycol)
OD
Overdose, analgesic (aspirin, acetaminophen)
OD
Overdose, antidepressants (cyclic, lithium)
OD
Overdose, other toxin, poison or drug
OD
Overdose, sedatives, hypnotics, antipsychotics, benzodiazepines
OD
Overdose, street drugs (opiates, cocaine, amphetamine)
CARDARR
Poisoning, carbon monoxide, arsenic, cyanide
SEIZ
Seizures (primary-no structural brain disease)
SAHICH
Subarachnoid hemorrhage/arteriovenous malformation
SAHICH
Subarachnoid hemorrhage/intracranial aneurysm
APACHE Disease
Mapping
SNEUROTH
SNEUROTH
SNEUROTH
SNEUROTH
SNEUROTH
SNEUROTH
SLAMINE
SNEUROTH
SNEUROTH
SLAMINE
SLAMINE
SSDH
SSDH
SICH
SLAMINE
SCRANNEO
SLAMINE
SNEUROTH
SNEUROTH
SNEUROTH

Neurologic (NEUROLOGIC)
Post-Operative
Abscess/infection-cranial, surgery for
Anastomosis, vascular
Arteriovenous malformation, surgery for
Biopsy, brain
Burr hole placement
Cerebrospinal fluid leak, surgery for
Complications of previous spinal cord surgery, surgery for
Cranial nerve, decompression/ligation
Cranioplasty and complications from previous craniotomies
Devices for spine fracture/dislocation
Fusion-spinal/Harrington rods
Hematoma, epidural, surgery for
Hematoma, subdural, surgery for
Hemorrhage/hematoma-intracranial, surgery for
Laminectomy/spinal cord decompression (excluding malignancies)
Neoplasm-cranial, surgery for (excluding transphenoidal)
Neoplasm-spinal cord surgery or other related procedures
Neurologic surgery, other
Seizures-intractable, surgery for
Shunts and revisions

Tab 4, P. 16 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
APACHE IV Calculations
Eff. Date: June 17, 2005
31TRGEXT000013
Owner: Critical Outcomes
SLAMINE
Spinal cord sugery, other
SNEUROTH
Stereotactic procedure
SSAH
Subarachnoid hemorrhage/intracranial aneurysm, surgery for
SLAMINE
Sympathectomy
SCRANNEO
Transphenoidal surgery
SNEUROTH
Ventriculostomy
APACHE Disease
Mapping
RESPOTH
PULEDEM
RESPARR
ALLERGY
RESPOTH
RESPCA
RESPCA
RESPCA
RESPCA
PLEUREFFUS
PULEMB
COPD
RESPOTH
RESPOTH
RESPOTH
RESPOTH
AIROBS
ASPPNEU
BACPNEU
PARAPNEU
BACPNEU
PARAPNEU
BACVPNEU
RESPOTH
RESPOTH
RESLUNGDIS
RESPOTH
RESPOTH

Respiratory (RESPIRAT)
Non-Operative
Apnea, sleep
ARDS-adult respiratory distress syndrome, non-cardiogenic pulmonary edema
Arrest, respiratory (without cardiac arrest)
Asthma
Atelectasis
Cancer, laryngeal
Cancer, lung
Cancer, oral
Cancer, tracheal
Effusions, pleural
Embolus, pulmonary
Emphysema/bronchitis
Hemorrhage/hemoptysis, pulmonary
Hemothorax
Hypertension-pulmonary, primary/idiopathic
Near drowning accident
Obstruction-airway (i.e. acute epiglottitis, post-extubation edema, foreign body, etc.)
Pneumonia, aspiration
Pneumonia, bacterial
Pneumonia, fungal
Pneumonia, other
Pneumonia, parasitic (i.e. Pneumocystis pneumonia)
Pneumonia, viral
Pneumothorax
Respiratory- medical, other
Restrictive lung disease (i.e. sarcoidosis, pulmonary fibrosis)
Smoke inhalation
Weaning from mechanical ventilation (transfer from other unit or hospital only)

Tab 4, P. 17 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
APACHE Disease
Mapping
SRESTOTH
SLUNG
SRESOTH
SRESPLAR
SRESPLAR
SRESOTH
SRESPINF
SRESOTH
SRESPCA
SRESOTH
SGICA
SRESPCA
SRESOTH
SRESPCA
SRESOTH
SLUNG
SRESPINF
SRESOTH

APACHE IV Calculations
31TRGEXT000013

Respiratory (RESPIRAT)
Post-Operative
Apnea-sleep; surgery for (i.e. UPPP -uvulopalatopharyngoplasty)
Biopsy, open lung
Bullectomy
Cancer oral/sinus, surgery for
Cancer-laryngeal/tracheal, surgery for
Facial surgery (if related to trauma, see Trauma)
Infection/abscess, other surgery for
Respiratory surgery, other
Thoracotomy for benign tumor (i.e. mediastinal chest wall mass, thymectomy
Thoracotomy for bronchopleural fistula
Thoracotomy for esophageal cancer
Thoracotomy for lung cancer
Thoracotomy for lung reduction
Thoracotomy for other malignancy in chest
Thoracotomy for other reasons
Thoracotomy for pleural disease
Thoracotomy for thoracic/respiratory infection
Tracheostomy

APACHE Disease
Transplant (TRANSPLANT)
Mapping
Non-Operative
RENOTH
Kidney transplant
HEPATF
Liver transplant
NON-PREDICTIVE ALL OTHER NON_OPERATIVE TRANSPLANTS
APACHE Disease
Transplant (TRANSPLANT)
Mapping
Post-Operative
SRENTRAN
Kidney transplant
SLIVERTR
Liver transplant
NON-PREDICTIVE ALL OTHER POST-OPERATIVE TRANSPLANTS
APACHE Disease
Mapping
MULTRAUM
MULTRAUM
MULTRAUM
MULTRAUM

Trauma (TRAUMA)
Non-Operative
Abdomen only trauma
Abdomen/extremity trauma
Abdomen/face trauma
Abdomen/multiple trauma

Tab 4, P. 18 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
MULTRAUM
Abdomen/pelvis trauma
MULTRAUM
Abdomen/spinal trauma
MULTRAUM
Chest/abdomen trauma
MULTRAUM
Chest/extremity trauma
MULTRAUM
Chest/face trauma
TRAUMCHSP
Chest/multiple trauma
MULTRAUM
Chest/pelvis trauma
TRAUMCHSP
Chest/spinal trauma
MULTRAUM
Chest/thorax only trauma
MULTRAUM
Extremity only trauma
MULTRAUM
Extremity/face trauma
MULTRAUM
Extremity/multiple trauma
MULTRAUM
Face only trauma
MULTRAUM
Face/multiple trauma
TRHEADONLY
Head (CNS) only trauma
HEADTR
Head/abdomen trauma
HEADTR
Head/chest trauma
TRHEADEXF
Head/extremity trauma
TRHEADEXF
Head/face trauma
TRHEADMULT
Head/multiple trauma
HEADTR
Head/pelvis trauma
HEADTR
Head/spinal trauma
MULTRAUM
Pelvis/extremity trauma
MULTRAUM
Pelvis/face trauma
MULTRAUM
Pelvis/hip only trauma
MULTRAUM
Pelvis/multiple trauma
MULTRAUM
Pelvis/spinal trauma
TRAUMSPINE
Spinal cord only trauma
MULTRAUM
Spinal/extremity trauma
MULTRAUM
Spinal/face trauma
MULTRAUM
Spinal/multiple trauma
MULTRAUM
Trauma medical, other
APACHE Disease
Mapping
SMULTR
Abdomen only trauma, surgery for
SMULTR
Abdomen/extremity trauma, surgery for

APACHE IV Calculations
31TRGEXT000013

Trauma (TRAUMA)
Post-Operative

Tab 4, P. 19 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
SMULTR
Abdomen/face trauma, surgery for
SMULTR
Abdomen/multiple trauma, surgery for
SMULTR
Abdomen/pelvis trauma, surgery for
SMULTR
Abdomen/spinal trauma, surgery for
SMULTR
Chest/abdomen trauma, surgery for
SMULTR
Chest/extremity trauma, surgery for
SMULTR
Chest/face trauma, surgery for
SMULTR
Chest/multiple trauma, surgery for
SMULTR
Chest/pelvis trauma, surgery for
SMULTR
Chest/spinal trauma, surgery for
SMULTR
Chest/thorax only trauma, surgery for
STRAUMEXT
Extremity only trauma, surgery for
SMULTR
Extremity/face trauma, surgery for
SMULTR
Extremity/multiple trauma, surgery for
SMULTR
Face only trauma, surgery for
SMULTR
Face/multiple trauma, surgery for
STRHDONLY
Head (CNS) only trauma, surgery for
SHEADTR
Head/abdomen trauma, surgery for
SHEADTR
Head/chest trauma, surgery for
SHEADTR
Head/extremity trauma, surgery for
SHEADTR
Head/face trauma, surgery for
SHEADTR
Head/multiple trauma, surgery for
SHEADTR
Head/pelvis trauma, surgery for
SHEADTR
Head/spinal trauma, surgery for
SMULTR
Pelvis/extremity trauma, surgery for
SMULTR
Pelvis/face trauma, surgery for
SMULTR
Pelvis/hip only trauma,surgery for
SMULTR
Pelvis/multiple trauma, surgery for
SMULTR
Pelvis/spinal trauma, surgery for
SMULTR
Spinal cord only trauma, surgery for
SMULTR
Spinal/extremity trauma, surgery for
SMULTR
Spinal/face trauma, surgery for
SMULTR
Spinal/multiple trauma, surgery for
SMULTR
Trauma surgery, other

APACHE IV Calculations
31TRGEXT000013

Tab 4, P. 20 of 36
Reviewer: Fern Malila
Approver: Kim Hlobik

Rev. 001
Eff. Date: June 17, 2005
Owener: Critical Outcomes

APACHE IV HOSPITAL MORTALITY


Intercept
Age

Tab 5, p. 21 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013

NON-CABG PATIENT OValue


1
0
0
0
0
0
0

Age
AGE1
AGE2
AGE3
AGE4
AGE5

Chronic Health (0/1)*


None
AIDS
For non-op and emergency
Hepatic Failure
surgery pts., select item used
Lymphoma
to calculate APACHE III score.
If multiple chronic health items are presenMetastatic Cancer
use the one with the highest point value (Leukemia/Multiple Myeloma
APACHE IV spreadsheet), NOT the one wit Immunosuppression
the highest coefficient.
Cirrhosis

Coefficient
Knot Points Cross Product
-5.950471952
-5.9504719516
0.0241774552
0
-4.3886E-006
27
0
5.01422E-005
51
0
-0.000127787
64
0
0.000109606
74
0
-2.7572E-005
86
0
0
0
0
0
0
0
0
0

0.9581005157
1.0373799253
0.743471748
1.0864237522
0.9693082989
0.4355810827
0.8146650877

0
Acute Physiology Score
Enter the Acute Physiology
Score. Splining of this variable
will autocalculate APS3ALL

APS
APS3ALL1
APS3ALL2
APS3ALL3
APS3ALL4
APS3ALL5

0 0.0556349159
0 8.71852E-006
0 -4.5110E-005
0.00005038
0
0 -1.3123E-005
0 -8.6535E-007
-0.000397068

PA/FI Ratio

10
22
32
48
89

0
0
0
0
0
0
0

Ventilated at any time during ICU Day 1

1=Yes

0.2717600356

ICU Admission Information (0/1)

Adm to ICU from floor


Transfer to ICU from
other hospital
Admit to ICU from OR/PACU

0.0171491928

0.0221062655
-0.583828121

0
0

Select only one

Rev. 001
Eff. Date: June 17, 2005
Owener: Critical Outcomes

Emergency Surgery

PreICU LOS in days

Admitting Diagnosis*
*See mapping table
*Select only one

Tab 5, p. 22 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013

0.2490734585

0/1
# Days between ICU
and Hosp Admission
square root of days (aut
PRELOS21
PRELOS22
PRELOS23
PRELOS24

ACIDBASE
AIROBS
ALLERGY
AMI_ANT
AMI_INFRLATR
AMI_NONQ
ASPPNEU
BACPNEU
BACVPNEU
CARDARR
CARDIOG
CARDIOMY
CHESTPAIN
CHFD
COAGTHRO
COMAMETU
COPDD
CVOTH
DIABETIC
DRUGTOXIC
GENOTH
GIBLEED

0
0
0
0
0

-0.310487496
1.4746725115
-2.8618857
1.4216590103
-0.034445822

-0.640575517
-0.977669154
-1.540678498
0.1029497654
-0.152525079
-0.270872458
-0.37223658
-0.043365914
0.2543749044
0.4169191406
0.2397114719
0.0599624438
-1.122354572
-0.422587793
0.2581724351
-0.927156778
-0.398697453
-0.369658509
-1.775702142
-0.690943246
-0.667576408
-0.551832894

0.121
0.423
0.794
2.806

0
0
0
0
0

0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0

Rev. 001
Eff. Date: June 17, 2005
Owener: Critical Outcomes

Tab 5, p. 23 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013

GIBLEUL
GIBLVAR
GIINFLA
GINEOP
GIOBSTR
GIOTHER
GIPERF
GIVASC
HEADTR
HEMAMISC
HEMORRHAGE
HEPATF
HYPERT
HYPOVOLEM
ICHMED
MEDAORT
METAMISC
MULTRAUM
NEONEUR
NEURINF
NEURMUS
NEUROTH
OD
PANCRE
PARAPNEU
PERIART
PERITOHEM
PLEUREFFUS
PULEDEM
PULEMB
RENOTH
RESLUNGDIS

-0.579471867
-0.527719358
-0.211771894
0.1951302908
-0.369945003
-0.252586643
-0.327171182
0.714879336
-0.372350315
-0.342352862
-0.656757432
-0.119675791
-0.813921325
-0.622592285
0.9450561547
0.6491493051
-0.986438209
-0.678110274
0.0189527274
-0.535783229
-0.550653067
-0.176828697
-1.55261952
-0.513627563
1.0561873472
-0.502752032
-0.659544401
0.1899005237
-0.2416873
-0.051527401
-0.54158014
1.5552965796

0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0

Rev. 001
Eff. Date: June 17, 2005
Owener: Critical Outcomes

Tab 5, p. 24 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013

RESPARR
RESPCA
RESPOTH
RHYTHM
SAGRAFT
SAHICH
SAHMED
SAMPUTATE
SAORTDIS
SCABGVALV
SCARDOTH
SCAROTID
SCRANNEO
SEIZ
SELAORT
SEPSISCUT
SEPSISGI
SEPSISOTH
SEPSISPULM
SEPSISUNK
SEPTICUT
SFEMPGRAF
SGIABCES
SGIBLEE
SGICA
SGICHOL
SGIINFL
SGIOBS
SGIOTH
SGIPERF
SGIVASC
SHEADTR

-0.390631425
0.966313802
-0.202823617
-0.603060945
-0.831194514
0.6159503846
0.2950939014
0.604910303
-0.178456475
-1.199434806
-0.59044574
-1.332642438
-0.437737676
-0.942170992
-0.760703396
0.1264403154
-0.13010935
-0.04233671
-0.258766455
-0.093377498
-0.732788506
-0.786571016
-0.556661177
-0.329679773
0.1362826618
-0.593293673
-0.165585527
-0.189005132
-0.295894316
-0.189960264
0.4983280142
0.3577977348

0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0

Rev. 001
Eff. Date: June 17, 2005
Owener: Critical Outcomes

SICH
SLAMINE
SLIVERTR
SLUNG
SMULTR
SNEUROTH
SOBHYST
SPERISC
SRENCA
SRENOTH
SRENTRAN
SRESOTH
SRESPCA
SRESPINF
SRESPLAR
SRUPAOR
SSAH
SSDH
STRAUMEXT
STRHDONLY
STROKE
SVALVE
SVHDCABG
TRAUMCHSP
TRAUMSPINE
TRHEADEXF
TRHEADMULT
TRHEADONLY
USTAANG

0.5267174102
-0.628609547
-1.370278559
0.4057380077
-0.377807998
0.0039963394
-0.795847883
-0.504208244
-1.397212695
-0.693574061
-1.308449407
-0.249217228
0.086933576
-0.005937516
-1.152870135
0.204404736
0.318905704
0.7156826217
-0.180386981
1.0888193243
0.5194530354
-1.371763972
-0.155141644
-0.717432122
0.0337694835
-0.364128015
-0.067960926
0.5958694161
-1.212730735
0

IF diagnosis is ACUTEMI

Tab 5, p. 25 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013

Thrombolytic Therapy

0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0

-0.579874039

Rev. 001
Eff. Date: June 17, 2005
Owener: Critical Outcomes

Unable to obtain GCS


due to meds, sedation, or anesthesia.
See methodology for rules.

(Unable = 1)

GCS

Eyes + Motor + Verbal

Adjusted GCS (autocalc)

Sum of cross products


Natural antilog of sum =x

Prediction = x/(1+x)

Tab 5, p. 26 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013

0.7857643165

0 0.0391175318

-5.9504719516
0.002604611

0.26%

Note: Predictions after the initial day contain an additional variable that updates the patient's APACHE III score for changes in physiological status,
and the relative contributions of age and comorbidities are also different on subsequent days. These equations are intended to be used to generate
hospital mortality prediction on Day 1 of the patient's ICU stay ONLY. Using these coefficients for other days is inappropriate and will yield erroneous
predictions.

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
HOSPITAL MORTALITY-CABG Only

Tab 6, p.27 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013
CABG Patient Only
Intercept

Age (0/1) Select one

<45
45-54
55-59
60-64
65-69
70-74
75-84
>=85

Chronic Health

Do not use chronic


health items for
CABG mortality
prediction.

Acute Physiology Score


Enter the Acute Physiology
Score. Splining of this variable
will autocalculate APS3ALL
Internal calculations,
do not change

APS
EQ18_APS3ALL1
EQ18_APS3ALL2
EQ18_APS3ALL3
EQ18_APS3ALL4
kd
diff

Emergency Surgery

CABG-Specific Variables
Enter all that apply

Value
1

Coefficient
Knot PointCross Product
-7.246664
-7.246664

0
0

0
-0.737078
-0.765009
-0.529345
-0.222009
0.107859
0.169567
0.765707

0
0
0
0
0
0
0
0

0
0
0
0
0
17.784467
30

0.044207
0.17313
-0.041316
-1.145473
1.713847

0/1

0.76644

Female (yes=1)
Redo CABG (yes=1)
Number of grafts

0.861304
1.206335
0.082575

0
0
0

15
30
40
50
60
90

0 Internal calculations, do not change


0
0
0
0
0
0
0
0
0
0
0
0

0
0
0
0

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
Sum of cross products
Natural antilog of sum =x

Prediction = x/(1+x)

Tab 6, p.28 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013
-7.246664
0.00071255

0.07%

Note: Predictions after the initial day contain an additional variable that updates the patient's APACHE III score for changes in physiological status,
and the relative contributions of age and comorbidities are also different on subsequent days. This equation is intended to be used to generate
hospital mortality prediction on Day 1 of the patient's ICU stay ONLY. Using these coefficients for other days is inappropriate and will yield erroneous
predictions.

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
APACHE IV ICU LENGTH OF STAY
Intercept
Age (0/1) Select one

Tab 7, p. 29 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013
NON CABG Patient Only

Value

Age
AGE1
AGE2
AGE3
AGE4
AGE5

Coefficient
Knot Points Cross Product
1 1.6738879246
1.6738879246
0.0176033952
0
27
0 -7.6826E-006
0
51
0 3.95667E-005
0
64
0 -0.000166793
0
74
0 0.0002281564
0
86
0 -9.3248E-005
0
0
-0.10285942
-0.16012995
-0.28079854
-0.491932974
-0.803754341
-0.07438064
0.3626586131

Chronic Health (0/1)*


None
For non-op and emergency
AIDS
surgery pts., select item used
Hepatic Failure
to calculate APACHE III score.
Lymphoma
If multiple chronic health items are present,Metastatic Cancer
use the one with the highest point value (seLeukemia/Multiple Myeloma
APACHE IV spreadsheet), NOT the one with Immunosuppression
the highest coefficient.
Cirrhosis

0
0
0
0
0
0
0
0

0
Acute Physiology Score
Enter the Acute Physiology
Score. Splining of this variable
will autocalculate APS3ALL

APS
APS3ALL1
APS3ALL2
APS3ALL3
APS3ALL4
APS3ALL5

PaO2/FIO2 Ratio

0.0444269895
0 -5.8305E-005
0 0.0002970084
0 -0.000404434
0 0.0001892508
0 -2.3520E-005

10
22
32
48
89

0
0
0
0
0
0

-0.004581842

Ventilated at any time during ICU Day 1

1=Yes

1.8353095408

ICU Admission Information (0/1)

Adm to ICU from floor

0.0065293818

Select only one

Transfer to ICU from other


hospital
Admit to ICU from OR/PACU

0.8555050425
-0.599591763

0
0

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

Tab 7, p. 30 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013
0

Readmit

0/1

0.5403684594

Emergency Surgery

0/1

1.0406906318

0.4598231293
0.3977919374
-0.945210953
0.5886512665
-0.041232251

0
0
0
0
0
0

PreICU LOS in days

Admitting Diagnosis*
*See mapping table
*Select only one

# Days between ICU and Hosp


Admission
square root of days (autocalc)
PRELOS21
PRELOS22
PRELOS23
PRELOS24
ACIDBASE
AIROBS
ALLERGY
AMI_ANT
AMI_INFRLATR
AMI_NONQ
ASPPNEU
BACPNEU
BACVPNEU
CARDARR
CARDIOG
CARDIOMY
CHESTPAIN
CHFD
COAGTHRO
COMAMETU
COPDD
CVOTH
DIABETIC
DRUGTOXIC

0
0
0
0
0

-0.382017407
0.3471484637
-0.542185912
0.0857685121
-0.036016015
-0.057916835
0.8602584271
1.3067446009
1.1560647567
-0.751470488
0.3299898856
0.5570053879
-0.520128136
-0.219091549
0.3998174157
-0.081962609
-0.446092483
-0.132883369
-0.58421484
-0.882634505

0.121
0.423
0.794
2.806

0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

Tab 7, p. 31 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013
GENOTH
GIBLEED
GIBLEUL
GIBLVAR
GIINFLA
GINEOP
GIOBSTR
GIOTHER
GIPERF
GIVASC
HEADTR
HEMAMISC
HEMORRHAGE
HEPATF
HYPERT
HYPOVOLEM
ICHMED
MEDAORT
METAMISC
MULTRAUM
NEONEUR
NEURINF
NEURMUS
NEUROTH
OD
PANCRE
PARAPNEU
PERIART
PERITOHEM
PLEUREFFUS
PULEDEM
PULEMB

-0.420843422
0.0213604052
0.1856965939
-0.083385343
0.532982522
1.3368312875
2.0686144603
0.5565887447
2.2086995672
1.9440608345
2.1289081715
-0.126173954
-0.381155309
0.1949458349
-0.067961418
-0.389881468
0.8632948203
1.3106215068
-0.363969853
1.5211879362
0.9748471868
1.1655653196
3.9256604297
0.3575043808
-0.89006849
2.7626886748
1.6197005464
0.8443265288
0.1652656354
0.8100930286
1.4427509398
0.1068340489

0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

Tab 7, p. 32 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013
RENOTH
RESLUNGDIS
RESPARR
RESPCA
RESPOTH
RHYTHM
SAGRAFT
SAHICH
SAHMED
SAMPUTATE
SAORTDIS
SCABGVALV
SCARDOTH
SCAROTID
SCRANNEO
SEIZ
SELAORT
SEPSISCUT
SEPSISGI
SEPSISOTH
SEPSISPULM
SEPSISUNK
SEPTICUT
SFEMPGRAF
SGIABCES
SGIBLEE
SGICA
SGICHOL
SGIINFL
SGIOBS
SGIOTH
SGIPERF

-0.152233731
1.024903996
-0.053291846
-0.140474342
0.2404909089
-0.302546395
0.5239223901
3.0086087597
1.1953150967
-0.325703861
1.1100214568
-1.358289429
-1.28358348
-0.14649332
0.319065119
-0.330810671
0.7739464631
1.5642195701
1.2453136733
0.6490771069
1.9266479992
0.4025902569
0.4531372416
-0.204188913
0.7199377967
-0.045403893
0.3248658754
-0.588512311
0.6869364416
0.1873047354
0.2170447191
1.0553746251

0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

Tab 7, p. 33 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013
SGIVASC
SHEADTR
SICH
SLAMINE
SLIVERTR
SLUNG
SMULTR
SNEUROTH
SOBHYST
SPERISC
SRENCA
SRENOTH
SRENTRAN
SRESOTH
SRESPCA
SRESPINF
SRESPLAR
SRUPAOR
SSAH
SSDH
STRAUMEXT
STRHDONLY
STROKE
SVALVE
SVHDCABG
TRAUMCHSP
TRAUMSPINE
TRHEADEXF
TRHEADMULT
TRHEADONLY
USTAANG

0.6206952495
3.20631279
2.9498695693
-0.251392367
-0.848656603
0.1859748668
1.4854303079
0.5513312249
-0.162493249
0.1022934618
-0.423760975
-0.58901834
-0.556650506
-0.359443815
0.1999254548
0.044451048
-0.053892181
2.7766388797
2.599592539
1.3423449617
-0.481004907
2.1021826433
0.3132337931
-2.076438218
-0.332456954
2.574268317
2.1681426709
0.8600333425
3.6375602953
0.834081141
-0.368981979
0

0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

Tab 7, p. 34 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013

IF diagnosis is ACUTEMI

Thrombolytic Therapy

Unable to obtain GCS

(Unable = 1)

0.062385214

1.7893266131

0 -0.015182904

due to meds, sedation, or anesthesia. See


methodology for rules.
GCS

Eyes + Motor + Verbal


Adjusted GCS (autocalc)

Sum of cross products

Prediction (days)
Note: Length of Stay predictions are intended to be used to generate ICU length of stay predictions on
Day 1 of the patient's stay ONLY.
Using these coefficients for other days is inappropriate and will yield erroneous predictions.

1.6738879246

1.67

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes
ICU Length of Stay-CABG ONLY
Age (0/1) Select one

Tab 8, p. 35 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013
CABG Patient Only
Intercept
AGE
EQ18_AGE1
EQ18_AGE2
EQ18_AGE3
EQ18_AGE4
EQ18_AGE5

Value

Coefficien Knot PointCross Product


1 2.004583
2.004583
0.012994
0
0 -8.19E-06
46
0
0 5.92E-05
59
0
0 -0.000181
67
0
0 0.000189
73
0
0 -5.94E-05
81
0

Chronic Health

Do not use chronic health health items for


CABG mortality prediction.

Diabetes (medication dependent)

(yes=1)

0 0.159896

Acute Physiology Score


Enter the Acute Physiology
Score. Splining of this variable
will autocalculate APS3ALL

APS
EQ18_APS3ALL1
EQ18_APS3ALL2
EQ18_APS3ALL3
EQ18_APS3ALL4
EQ18_APS3ALL5

0
0
0
0
0

Emergency Surgery

0/1

0 0.284642

Creatinine

CREA
EQ18_CREA1
EQ18_CREA2
EQ18_CREA3
EQ18_CREA4
EQ18_CREA5

0
0
0
0
0

-0.02843
0.000126
-0.000295
0.000167
-1.04E-06
2.85E-06

-0.004945
-3.581329
21.94124
-608.0213
591.272
-1.610631

15
25
32
40
61

0
0
0
0
0
0
0

0.6
0.8
1.09
1.1
1.9

0
0
0
0
0
0

Rev. 001
Eff. Date: June 17, 2005
Owner: Critical Outcomes

Tab 8, p. 36 of 36
Reviewed by: Fern Malila
Approved by: Kim Hlobik

APACHE IV Calculations
31TRGEXT000013

Ejection Fraction

PLVEJECT
EQ18_PLVEJECT1
EQ18_PLVEJECT2
EQ18_PLVEJECT3
EQ18_PLVEJECT4
EQ18_PLVEJECT5

0
0
0
0
0
0

-0.005927
-7.65E-06
20
0.000136
45
-0.000334 54.21552
0.000211
60
5.06E-06
99

CABG-Specific Variables
Enter all that apply

Female (yes=1)
Redo CABG (yes=1)
IMA used (yes=1)
MIDUR (yes=1)
Number of grafts = 2
Number of grafts = 3
Number of grafts = 4
Number of grafts = 5
Number of grafts = 6
Number of grafts >=7

0.278597
0.336221
-0.197821
0.214881
0.052944
0.111277
-0.053388
-0.233051
-0.437164
0 -0.482726

0
0
0
0
0
0

0
0
0
0
0
0
0
0
0
0

0
Sum of cross products

Prediction =

2.004583

2.00

Note: Predictions after the initial day contain an additional variable that updates the patient's APACHE III score for changes in physiological status,
and the relative contributions of age and comorbidities are also different on subsequent days. This equation is intended to be used to generate
hospital mortality prediction on Day 1 of the patient's ICU stay ONLY. Using these coefficients for other days is inappropriate

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