Robert Willner

Robert Willner (died 15 April 1995) was a doctor from Florida who became famous for his role in AIDS
denialism - the view that AIDS is not caused by the HIV virus.
Willner authored a book presenting his point of view on the relation between HIV and AIDS, titled "Deadly
Deception: the Proof That Sex And HIV Absolutely Do Not Cause AIDS". The book was published shortly
after Willner's medical license was revoked for, among other things, treating an AIDS patient with ozone
therapy.
The following month, on October 28, 1994, in a press conference at a North Carolina hotel, Willner jabbed
[2]
his finger with blood he said was from an HIV-infected patient. Willner died six months later, on April 15,
1995, of a heart attack.
It is historical fact that the pharmaceutical industry (the oil and chemical industry) has been the major force
responsible for the narrow, arrogant and simple minded path that has brought physicians success in less
than ten percent (<10%) of the diseases they are called upon to treat.
The pharmaceutical complex provides research grants, contracts and advertising support responsible for the
existence of many thousands of journals published each year. This guarantees virtual control over scientific
and medical direction and thought. The result has been highly profitable.
By creating a dogmatic religious zeal in search of the "Holy Grail" the cure of all disease by drugs, the
average physician has become totally intolerant of all other schools of thought and practice. The great
majority of physicians are honest, dedicated and sincere scientists. They truly believe that they are on the
"cutting edge" of medicine and that anyone who pursues another path is either misguided, ill-informed, a
charlatan, or a quack. The modern day inquisitions, which take the form of administrative hearings, deny
victims of their constitutional rights. They have resulted in the loss of license to practice medicine the heavy
fines for many physicians searching for safer and better ways to treat disease. A period of probation is
always added to insure that the victim repents and does not revert to the use of heretical measures in the
treatment of patients. There are many thousands of physicians who practice what they believe to be a better
brand of medicine, but they have to do so in constant fear of discovery. There would be hundreds of
thousands more if they were ever given the chance to learn of the non-toxic and effective (by historical
usage) therapies available.
I mourn for Hippocrates, whose admonitions to "Above all, do not harm" and "let your food be your medicine
and your medicine be your food" have been discarded in favour of the doctrine of the "lesser of the evils." As
long as physicians pursue the "magic bullet" and ignore the lessons of thousands of years of knowledge and
experience, iatrogenic (medically caused) illness and death will become more prevalent than ever. The food
and Drug Administration is continuously adding, eliminating or revising information on the use of medicines
because of serious problems noted long after the FDA cleared them for safety and effectiveness. In spite of
the fact that they were born of the "double-blind" birth process, these changes interestingly enough were
discovered, not by double-blind techniques, but by anecdotal evidence. The actual occurrence of the coverup and masking of the failures in the "infallibility" of the double-blind criteria of proof is much greater than
admitted or known, because of the limitations inherent in the allopathic philosophy and its intolerance to any
other point of view. As long as the dictatorship of allopathic medicine reigns, fostered by the powerful and
politically influential pharmaceutical industry, the public will be denied the right of informed freedom of choice
in health and disease care.
THE DOUBLE-EDGED SWORD
Modern medicine has excelled in advancing the technology for diagnosis and for the treatment of crisis
situations (trauma). Surgical procedures have been developed that accomplish miraculous results and have
not only saved many lives, they have brought or restored a decent quality of life to millions. When analyzed

carefully, these advances have been mechanical in character, but still ultimately rely on the natural healing
processes for success.
Sadly, these technological miracles have, in many instances, been abused because of ignorance and the
lust for profit. It is in the area of crisis medicine that physicians can boast of most of their achievements. Yet
it represents only a pitifully small part of the problems it faces. Lest undue credit be sought for antibiotics and
vaccines, it should be pointed out that the great advances in sanitation and hygiene have been far more
responsible for the control of infectious disease. In these instances, only those methods which utilize natural
means are ultimately safe and effective.
The incredible gains in the interest of public health in the area of hygiene and sanitation are now being
overshadowed and lost. A new disaster has been in the making and is being caused by the industrial
revolution that brought us the technologies of improved sanitation. Like the surgeons knife, most scientific,
medical and technological advances have proven to be a double-edged sword. We learn daily that some
drug, chemical, pesticide, or food additive is being removed form the marketplace or is under serious
suspicion after many years of use. We now know, without any doubt, that millions more are dying form the
"advances" of modern medicine and science than from all the forces of nature and mankinds war machines
combined.
Dr. Robert E. Willner was an independent physician and author

Dr Willner was the author of The Cancer Solution & Deadly Deception, and an outspoken critic of the AIDS
industry. He appeared on Spanish TV where he mixed his blood with the blood of an HIV positive man to
demonstrate his belief that HIV was not the cause of AIDS. (Dr. WIllner established that AZT was toxic and
mortal to those with HIV/AIDS)
His suggested prime therapies were Budwig Diet, Chelation therapy, Laetrile, Ozone therapy, Pulsed
Magnetic therapy, 714X, Glyoxide, Proteolytic enzymes, rectal Coffee instillation (used commonly in
mainstream medicine for decades until the mid 1970s), Colonic cleansing, Cryogenic and Live cell therapy,
Mind-spiritual support, Therapeutic vitamin/minerals, Rene Caisse's herbal cancer remedy.
"During the last 10 years of my practice I utilised many therapies that were not in the
mainstream of medicine. They were safe, non-toxic and very effective. When I retired I
travelled and researched other therapies...I spoke with many doctors and patients who were
getting excellent results from these alternative therapies and witnessed their success first
hand. It is time to seriously question and reject the standard orthodox cancer treatments of
surgery, radiation and chemotherapy, except in a very few instances.
You may have difficulty in obtaining some of these therapies because the FDA has
literally pressured Congress, under the guise of protecting the public, to keep time-honoured
cultural and natural therapies out of the hands of the general public. If you look at the record
of the FDA, it becomes obvious they are serving interests other than yours and mine.
The 'cancer establishment' is a network of extremely powerful and wealthy companies
whose members sit on the boards of many non-profit organisations. They literally control
and direct all cancer research within the USA and throughout the world......Although these
centres are non-profit they serve their masters by suppressing most, if not all, nonpatentable treatments in favour of the expensive treatments therapies that have wrought
havoc with patients while losing the war against cancer."
---Dr Willner
References

1. Willner, Robert (September 1994). Deadly Deception: the Proof That Sex And HIV Absolutely Do
Not Cause AIDS. Peltec Publishing Company Inc. ISBN 978-0964231610.
http://www.amazon.com/Deadly-Deception-Proof-Absolutely-Cause/dp/0964231611.
2. Cohen, J. (1994). "The Duesberg phenomenon" (PDF). Science 266 (5191): 16421644.
doi:10.1126/science.7992043. PMID 7992043. http://www.sciencemag.org/feature/data/cohen/2665191-1642a.pdf.
3. Bugl, Paul. "The Rise of HIV/AIDS". Department of Mathematics, University of Hartford.
http://uhavax.hartford.edu/bugl/rise.htm. Retrieved 2007-01-22.
4. http://en.wikipedia.org/wiki/Robert_Willner

Many scientists, doctors and researchers and African Traditional Healers contend that AIDS is not a new
disease, having been around much longer than people believe.
Dr. Robert Willnerauthor of Deadly Deception: He claims that nearly 500 hundred top scientists of the
world have challenged the hypothesis of Robert Gallowho patented the HIV test the day after the HIV virus
was discovered.
HIV is a virus, Aids is a condition Sometimes they occur together and some times separately.
( Dr Hulda R Clark)

Cancer and Alternative medicines ( South Africa RSA Pretoria

(Tshwane) )
"Most of what you have heard over your lifetime about cancer treatments is not the truth.
At the very least, you have received an incomplete picture. - John Diamond MD,
In opinion of our Healer cancer is not a localized condition. To heal cancer , the whole body
needs to be healed. There is also an emotional, psychological and nutritional factor involve.
We use intensive non-toxic, highly bioavailable nutraceuticals that induce the body to fight
cancer cells.

We Suggest special diet to clean the body from many toxins and heavy metals. A few dietary
supplements and a custom design Magnetic therapy. Also unblocking body's glands and immune
system, to remove parasites, viruses and funguses and replace them with friendly bacteria.
There are several African plants known for their properties against cancer one of them is
Agricultural soils have been depleted due to practices that have failed to replenish the
minerals after repeated planting.
Diet, Detox Formula, Hypoxis , Kombucha, Potassium, Selenium, Beta
Free Consultation
and Alfa Carotene, Vitamin A&E, Omega 3, Essiac Tea, Southerlandia, Green tea extract
Cancer and sugar

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Cancer and Sugar

Cancer Cells Preferentially
use Sugars. References
by Patrick Quillin, PHD, RD, CNSfrom the book Beating Cancer with Nutrition Highly
recommended reading.
During the last 10 years I have worked with more than 500 cancer patients as director of
nutrition for Cancer Treatment Centers of America in Tulsa, Okla. It puzzles me why the
simple concept "sugar feeds cancer" can be so dramatically overlooked as part of a
comprehensive cancer treatment plan.
Of the 4 million cancer patients being treated in America today, hardly any are offered any
scientifically guided nutrition therapy beyond being told to "just eat good foods." Most
patients I work with arrive with a complete lack of nutritional advice. I believe many cancer

patients would have a major improvement in their outcome if they controlled the supply of
cancer's preferred fuel, glucose. By slowing the cancer's growth, patients allow their immune
systems and medical debulking therapies--chemotherapy, radiation and surgery to reduce
the bulk of the tumor mass--to catch up to the disease. Controlling one's blood-glucose
levels through diet, supplements, exercise, meditation and prescription drugs when
necessary can be one of the most crucial components to a cancer recovery program. The
sound bite--sugar feeds cancer--is simple. The explanation is a little more complex.
The 1931 Nobel laureate in medicine, German Otto Warburg, Ph.D., first discovered that
cancer cells have a fundamentally different energy metabolism compared to healthy cells.
The crux of his Nobel thesis was that malignant tumors frequently exhibit an increase in
anaerobic glycolysis--a process whereby glucose is used as a fuel by cancer cells with lactic
acid as an anaerobic byproduct--compared to normal tissues.1 The large amount of lactic
acid produced by this fermentation of glucose from cancer cells is then transported to the
liver. This conversion of glucose to lactate generates a lower, more acidic pH in cancerous
tissues as well as overall physical fatigue from lactic acid buildup.2,3 Thus, larger tumors
tend to exhibit a more acidic pH.4
This inefficient pathway for energy metabolism yields only 2 moles of adenosine
triphosphate (ATP) energy per mole of glucose, compared to 38 moles of ATP in the
complete aerobic oxidation of glucose. By extracting only about 5 percent (2 vs. 38 moles of
ATP) of the available energy in the food supply and the body's calorie stores, the cancer is
"wasting" energy, and the patient becomes tired and undernourished. This vicious cycle
increases body wasting.5 It is one reason why 40 percent of cancer patients die from
malnutrition, or cachexia.6
Hence, cancer therapies should encompass regulating blood-glucose levels via diet,
supplements, non-oral solutions for cachectic patients who lose their appetite, medication,
exercise, gradual weight loss and stress reduction. Professional guidance and patient selfdiscipline are crucial at this point in the cancer process. The quest is not to eliminate sugars
or carbohydrates from the diet but rather to control blood glucose within a narrow range to
help starve the cancer and bolster immune function.
The glycemic index is a measure of how a given food affects blood-glucose levels, with each
food assigned a numbered rating. The lower the rating, the slower the digestion and

absorption process, which provides a healthier, more gradual infusion of sugars into the
bloodstream. Conversely, a high rating means blood-glucose levels are increased quickly,
which stimulates the pancreas to secrete insulin to drop blood-sugar levels. This rapid
fluctuation of blood-sugar levels is unhealthy because of the stress it places on the body
(see glycemic index chart, p. 166).

Sugar in the Body and Diet

Sugar is a generic term used to identify simple carbohydrates, which includes
monosaccharides such as fructose, glucose and galactose; and disaccharides such as
maltose and sucrose (white table sugar). Think of these sugars as different-shaped bricks in
a wall. When fructose is the primary monosaccharide brick in the wall, the glycemic index
registers as healthier, since this simple sugar is slowly absorbed in the gut, then converted
to glucose in the liver. This makes for "time-release foods," which offer a more gradual rise
and fall in blood-glucose levels. If glucose is the primary monosaccharide brick in the wall,
the glycemic index will be higher and less healthy for the individual. As the brick wall is torn
apart in digestion, the glucose is pumped across the intestinal wall directly into the
bloodstream, rapidly raising blood-glucose levels. In other words, there is a "window of
efficacy" for glucose in the blood: levels too low make one feel lethargic and can create
clinical hypoglycemia; levels too high start creating the rippling effect of diabetic health
problems.
The 1997 American Diabetes Association blood-glucose standards consider 126 mg
glucose/dL blood or greater to be diabetic; 111125 mg/dL is impaired glucose tolerance
and less than 110 mg/dL is considered normal. Meanwhile, the Paleolithic diet of our
ancestors, which consisted of lean meats, vegetables and small amounts of whole grains,
nuts, seeds and fruits, is estimated to have generated blood glucose levels between 60 and
90 mg/dL.7 Obviously, today's high-sugar diets are having unhealthy effects as far as bloodsugar is concerned. Excess blood glucose may initiate yeast overgrowth, blood vessel
deterioration, heart disease and other health conditions.8
Understanding and using the glycemic index is an important aspect of diet modification for
cancer patients. However, there is also evidence that sugars may feed cancer more
efficiently than starches (comprised of long chains of simple sugars), making the index

slightly misleading. A study of rats fed diets with equal calories from sugars and starches,
for example, found the animals on the high-sugar diet developed more cases of breast
cancer.9 The glycemic index is a useful tool in guiding the cancer patient toward a healthier
diet, but it is not infallible. By using the glycemic index alone, one could be led to thinking a
cup of white sugar is healthier than a baked potato. This is because the glycemic index
rating of a sugary food may be lower than that of a starchy food. To be safe, I recommend
less fruit, more vegetables, and little to no refined sugars in the diet of cancer patients.

What the litreature Says

A mouse model of human breast cancer demonstrated that tumors are sensitive to bloodglucose levels. Sixty-eight mice were injected with an aggressive strain of breast cancer,
then fed diets to induce either high blood-sugar (hyperglycemia), normoglycemia or low
blood-sugar (hypoglycemia). There was a dose-dependent response in which the lower the
blood glucose, the greater the survival rate. After 70 days, 8 of 24 hyperglycemic mice
survived compared to 16 of 24 normoglycemic and 19 of 20 hypoglycemic.10 This suggests
that regulating sugar intake is key to slowing breast tumor growth (see chart, p. 164).
In a human study, 10 healthy people were assessed for fasting blood-glucose levels and the
phagocytic index of neutrophils, which measures immune-cell ability to envelop and destroy
invaders such as cancer. Eating 100 g carbohydrates from glucose, sucrose, honey and
orange juice all significantly decreased the capacity of neutrophils to engulf bacteria. Starch
did not have this effect.11
A four-year study at the National Institute of Public Health and Environmental Protection in
the Netherlands compared 111 biliary tract cancer patients with 480 controls. Cancer risk
associated with the intake of sugars, independent of other energy sources, more than
doubled for the cancer patients.12 Furthermore, an epidemiological study in 21 modern
countries that keep track of morbidity and mortality (Europe, North America, Japan and
others) revealed that sugar intake is a strong risk factor that contributes to higher breast
cancer rates, particularly in older women.13
Limiting sugar consumption may not be the only line of defense. In fact, an interesting
botanical extract from the avocado plant (Persea americana) is showing promise as a new
cancer adjunct. When a purified avocado extract called mannoheptulose was added to a

number of tumor cell lines tested in vitro by researchers in the Department of Biochemistry
at Oxford University in Britain, they found it inhibited tumor cell glucose uptake by 25 to 75
percent, and it inhibited the enzyme glucokinase responsible for glycolysis. It also inhibited
the growth rate of the cultured tumor cell lines. The same researchers gave lab animals a
1.7 mg/g body weight dose of mannoheptulose for five days; it reduced tumors by 65 to 79
percent.14 Based on these studies, there is good reason to believe that avocado extract
could help cancer patients by limiting glucose to the tumor cells.
Since cancer cells derive most of their energy from anaerobic glycolysis, Joseph Gold, M.D.,
director of the Syracuse (N.Y.) Cancer Research Institute and former U.S. Air Force
research physician, surmised that a chemical called hydrazine sulfate, used in rocket fuel,
could inhibit the excessive gluconeogenesis (making sugar from amino acids) that occurs in
cachectic cancer patients. Gold's work demonstrated hydrazine sulfate's ability to slow and
reverse cachexia in advanced cancer patients. A placebo-controlled trial followed 101
cancer patients taking either 6 mg hydrazine sulfate three times/day or placebo. After one
month, 83 percent of hydrazine sulfate patients increased their weight, compared to 53
percent on placebo.15 A similar study by the same principal researchers, partly funded by
the National Cancer Institute in Bethesda, Md., followed 65 patients. Those who took
hydrazine sulfate and were in good physical condition before the study began lived an
average of 17 weeks longer.16
In 1990, I called the major cancer hospitals in the country looking for some information on
the crucial role of total parenteral nutrition (TPN) in cancer patients. Some 40 percent of
cancer patients die from cachexia.5 Yet many starving cancer patients are offered either no
nutritional support or the standard TPN solution developed for intensive care units. The
solution provides 70 percent of the calories going into the bloodstream in the form of
glucose. All too often, I believe, these high-glucose solutions for cachectic cancer patients
do not help as much as would TPN solutions with lower levels of glucose and higher levels
of amino acids and lipids. These solutions would allow the patient to build strength and
would not feed the tumor.17
The medical establishment may be missing the connection between sugar and its role in
tumorigenesis. Consider the million-dollar positive emission tomography device, or PET
scan, regarded as one of the ultimate cancer-detection tools. PET scans use radioactively

labeled glucose to detect sugar-hungry tumor cells. PET scans are used to plot the progress
of cancer patients and to assess whether present protocols are effective.18
In Europe, the "sugar feeds cancer" concept is so well accepted that oncologists, or cancer
doctors, use the Systemic Cancer Multistep Therapy (SCMT) protocol. Conceived by
Manfred von Ardenne in Germany in 1965, SCMT entails injecting patients with glucose to
increase blood-glucose concentrations. This lowers pH values in cancer tissues via lactic
acid formation. In turn, this intensifies the thermal sensitivity of the malignant tumors and
also induces rapid growth of the cancer. Patients are then given whole-body hyperthermia
(42 C core temperature) to further stress the cancer cells, followed by chemotherapy or
radiation.19 SCMT was tested on 103 patients with metastasized cancer or recurrent
primary tumors in a clinical phase-I study at the Von Ardenne Institute of Applied Medical
Research in Dresden, Germany. Five-year survival rates in SCMT-treated patients
increased by 25 to 50 percent, and the complete rate of tumor regression increased by 30 to
50 percent.20 The protocol induces rapid growth of the cancer, then treats the tumor with
toxic therapies for a dramatic improvement in outcome.
The irrefutable role of glucose in the growth and metastasis of cancer cells can enhance
many therapies. Some of these include diets designed with the glycemic index in mind to
regulate increases in blood glucose, hence selectively starving the cancer cells; low-glucose
TPN solutions; avocado extract to inhibit glucose uptake in cancer cells; hydrazine sulfate to
inhibit gluconeogenesis in cancer cells; and SCMT.
A female patient in her 50s, with lung cancer, came to our clinic, having been given a death
sentence by her Florida oncologist. She was cooperative and understood the connection
between nutrition and cancer. She changed her diet considerably, leaving out 90 percent of
the sugar she used to eat. She found that wheat bread and oat cereal now had their own
wild sweetness, even without added sugar. With appropriately restrained medical therapy-including high-dose radiation targeted to tumor sites and fractionated chemotherapy, a
technique that distributes the normal one large weekly chemo dose into a 60-hour infusion
lasting days--a good attitude and an optimal nutrition program, she beat her terminal lung
cancer. I saw her the other day, five years later and still disease-free, probably looking
better than the doctor who told her there was no hope.
Patrick Quillin, Ph.D., R.D., C.N.S., is director of nutrition for Cancer Treatment Centers of

America in Tulsa, Okla., and author of Beating Cancer With Nutrition (Nutrition Times Press,
1998).

Cancer and alternative medicines

Do not forget to bookmark the site.
Although we are providing a lots of free information we have to keep some
information back. The reason is that we have to make a living and to keep the site active.
These information shall be provided to the clients that are paying for consultation service and
purchasing our products.

If we write the whole information it become a book. Online consultation for alternative
treatments.
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References
1. Warburg O. On the origin of cancer cells. Science 1956 Feb;123:309-14.
2. Volk T, et al. pH in human tumor xenografts: effect of intravenous administration of glucose.
Br J Cancer 1993 Sep;68(3):492-500.
3.Digirolamo M. Diet and cancer: markers, prevention and treatment. New York: Plenum
Press; 1994. p 203.
4. Leeper DB, et al. Effect of i.v. glucose versus combined i.v. plus oral glucose on human
tumor extracellular pH for potential sensitization to thermoradiotherapy. Int J Hyperthermia
1998 May-Jun;14(3):257-69.
5. Rossi-Fanelli F, et al. Abnormal substrate metabolism and nutritional strategies in cancer
management. JPEN J Parenter Enteral Nutr 1991 Nov-Dec;15(6):680-3.
6. Grant JP. Proper use and recognized role of TPN in the cancer patient. Nutrition 1990 JulAug;6(4 Suppl):6S-7S, 10S.
7. Brand-Miller J, et al. The glucose revolution. Newport (RI) Marlowe and Co.; 1999.
8. Mooradian AD, et al. Glucotoxicity: potential mechanisms. Clin Geriatr Med 1999
May;15(2):255.

9. Hoehn, SK, et al. Complex versus simple carbohydrates and mammary tumors in mice. Nutr
Cancer 1979;1(3):27.
10. Santisteban GA, et al. Glycemic modulation of tumor tolerance in a mouse model of breast
cancer. Biochem Biophys Res Commun 1985 Nov 15;132(3):1174-9.
11. Sanchez A, et al. Role of sugars in human neutrophilic phagocytosis. Am J Clin Nutr 1973
Nov;26(11):1180-4.
12. Moerman CJ, et al. Dietary sugar intake in the aetiology of biliary tract cancer. Int J
Epidemiol 1993 Apr;22(2):207-14.
13. Seeley S. Diet and breast cancer: the possible connection with sugar consumption. Med
Hypotheses 1983 Jul;11(3):319-27.
14. Board M, et al. High Km glucose-phosphorylating (glucokinase) activities in a range of
tumor cell lines and inhibition of rates of tumor growth by the specific enzyme inhibitor
mannoheptulose. Cancer Res 1995 Aug 1;55(15):3278-85.
15. Chlebowski RT, et al. Hydrazine sulfate in cancer patients with weight loss. A placebocontrolled clinical experience. Cancer 1987 Feb 1;59(3):406-10.
16. Chlebowski RT, et al. Hydrazine sulfate influence on nutritional status and survival in nonsmall-cell lung cancer. J Clin Oncol 1990 Jan;8(1):9-15.
17. American College of Physicians. Parenteral nutrition in patients receiving cancer
chemotherapy. Ann Intern Med 1989 May;110(9):734.
18. Gatenby RA. Potential role of FDG-PET imaging in understanding tumor-host interaction. J
Nucl Med 1995 May;36(5):893-9.
19. von Ardenne M. Principles and concept 1993 of the Systemic Cancer Multistep Therapy
(SCMT). Extreme whole-body hyperthermia using the infrared-A technique IRATHERM 2000-selective thermosensitisation by hyperglycemia--circulatory back-up by adapted hyperoxemia.
Strahlenther Onkol 1994 Oct;170(10):581-9.
20. Steinhausen D, et al. Evaluation of systemic tolerance of 42.0 degrees C infrared-A wholebody hyperthermia in combination with hyperglycemia and hyperoxemia. A Phase-I study.
Strahlenther Onkol 1994 Jun;170(6):322-34.

Does Blood Sugar Affect Breast Cancer Survival?

Hyperglycemic

33% Survival Rate

Normoglycemic

67% Survival Rate

Hypoglycemic

95% Survival Rate

Conclusion: Higher blood glucose yields shorter survival time in a dose-dependent response.
Survival after 70 days was 8 of 24(hyper), 16 of 24 (normo) and 19 of 20 (hypo).
Study design: Mice were injected with aggressive breast cancer and then placed on 3 different
diets to alter blood glucose.

Santisteban GA, Biochem Biophys Res Comm 1985 Nov; 132(3): 1174-9.

African herbal medicines in the

treatment of HIV: Hypoxis and
Sutherlandia. An overview of
evidence and pharmacology
Edward Mills1
1

, Curtis Cooper2

, Dugald Seely3

and Izzy Kanfer4

Department of Clinical Epidemiology & Biostatistics, McMaster University, 1200 Main

Street West Hamilton, L8N 3Z5, Canada

2

Division of Infectious Diseases, University of Ottawa, 501 Smyth Rd., Ottawa, K1H 8L6,

Canada
3

Department of Clinical Epidemiology, Canadian College of Naturopathic Medicine, 1255

Sheppard Ave. East, North York, M2K1M2, Canada

4

Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa

author email

corresponding author email

Nutrition Journal 2005, 4:19doi:10.1186/1475-2891-4-19

The electronic version of this article is the complete one and can be found online at:
http://www.nutritionj.com/content/4/1/19

Received: 18 February 2005

Accepted: 31 May 2005
Published: 31 May 2005

2005 Mills et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits
unrestricted use, distribution, and reproduction in any medium, provided the original work
is properly cited.

Abstract
In Africa, herbal medicines are often used as primary treatment for HIV/AIDS and for HIVrelated problems. In general, traditional medicines are not well researched, and are poorly
regulated. We review the evidence and safety concerns related to the use of two specific
African herbals, which are currently recommended by the Ministry of Health in South Africa
and member states for use in HIV: African Potato and Sutherlandia. We review the
pharmacology, toxicology and pharmacokinetics of these herbal medicines. Despite the
popularity of their use and the support of Ministries of Health and NGOs in some African
countries, no clinical trials of efficacy exist, and low-level evidence of harm identifies the
potential for drug interactions with antiretroviral drugs. Efforts should be made by
mainstream health professionals to provide validated information to traditional healers and
patients on the judicious use of herbal remedies. This may reduce harm through failed
expectations, pharmacologic adverse events including possible drug/herb interactions and
unnecessary added therapeutic costs. Efforts should also be directed at evaluating the
possible benefits of natural products in HIV/AIDS treatment.

Review
The use of traditional medicine and Natural Health Products is widespread among those
living with HIV infection [1]. Many patients take a broad range of natural health products
(NHPs) in addition to their conventional therapeutic products [2-4]. In Africa, traditional
herbal medicines are often used as primary treatment for HIV/AIDS and for HIV-related
problems including dermatological disorders, nausea, depression, insomnia, and
weakness[2,5-8]. Some herbal and traditional medicines are not well-researched, poorly

regulated, may contain adulterated products, and may produce adverse effects [8-13].
Notwithstanding these concerns, the use of traditional medicines by Africans living with
HIV is believed to be widespread, although insufficiently documented [14-16].
Despite a paucity of evidence on effectiveness, and the possibility of harm, the Ministries
of Health of several African nations currently promote traditional medicines for the
treatment of HIV and associated symptoms [12,17]. In the case of South Africa, the
Ministry of Health is actively promoting the use of traditional medicines with antiretroviral
treatments[18].
Two principal African herbal compounds used for HIV/AIDS treatment in sub-Saharan
Africa include Hypoxis hemerocallidea (common name: African potato), and Sutherlandia.
These two herbal remedies are currently recommended by the South African Ministry of
Health for HIV management [17]. The 14 member states of the South African Development
Community (SADC) which includes Angola, Botswana, Democratic Republic of Congo,
Lesotho, Malawi, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Swaziland,
Tanzania, Zambia, and Zimbabwe, also support their use [19]. Responding to the
compelling need for evidence regarding traditional medicines, we reviewed the current
evidence for the use of these herbal remedies in HIV care.

Methods
With the aid of an information specialist, we searched the following databases
independently, in duplicate (from inception to December 2004):AltHealthWatch, AMED,
CancerLit, CinAhl, Cochrane Controlled Trials Register (CENTRAL), MedLine, and
EMBASE. In order to identify unpublished research, we searched Clinical trials.gov,
National Research Register (UK) and the Meta-Register. Searches were not limited by
language. We additionally searched bibliographies of identified reviews and contacted
experts in the field. The following search terms were used, but not limited to: "Medicine,
African Traditional", "Hypox*", "Sutherlandia", and "HIV."
Hypoxis hemerocallidea
Common names

Magic muthi, yellow stars, star lily, African potato (Eng.); sterretjie, Afrika-patat (Afr.);
inkomfe, ilabatheka, sterblom, gifbol, lotsane, molikharatsa[20,21]

Hypoxis is a well-known genus of the family Hypoxidaceae. Easily recognizable by its

bright yellow star-shaped flowers and strap-like leaves, it has a long history of medicinal
use on the African continent. The South African primary health care community is currently
using hypoxis as an immunostimulant for patients with HIV/AIDS. A daily dose of 2,400 mg
of raw plant is purported to be therapeutically effective [22]. Within the genus, two species,

H. hemerocallidea and H. colchicifolia are particularly popular both as African traditional

remedies and for the preparation of herbal teas and tinctures.
Rootstocks of this plant have been used by Zulu traditional healers for centuries in the
treatment of urinary infections, heart weakness, internal tumors, and nervous disorders
[21]. Other unproven uses for this herb include benign prostatic hypertrophy, cancer and
hyperglycemia [23-25]. The corms of H. hemerocallidea are being used for immune related
illnesses such as the common cold, flu, arthritis, cancer and HIV/AIDS. There is some
indirect evidence that sterols and sterolins, which are found in the root of Hypoxis, have
the potential to enhance immunity [26-28]. The popular press in South Africa is promoting
preparations of Hypoxis as an agent that can boost immunity in HIV/AIDS patients [29,30].
Multiple websites, popular magazines, and even the South African Ministry of Health have
supported this assertion [29-32]. Irrespective of the evidence, many Africans claim benefit
from eating the root of H. hemerocallidea [7,14].
Chemical constituents
An important constituent of the plant is a nor-lignan glycoside called hypoxoside, which
once in the human gut, readily converts to the aglycone, rooperol, a biologically active
compound that is purported to have medicinal properties [22,33]. The plant also contains
various sterols (-sitosterol, stigmasterol) and their glycosides (sterolins) such as sitosterol glycoside and stanols such as sitostanol also called stigmastanol, which have
also been purported to have important biological activity [26,28].
Pharmacology and Pharmacokinetics
Hypoxoside

Hypoxoside is not absorbed intact into the blood stream. Once in the body, hypoxoside is
converted into its aglycone, rooperol, a potent antioxidant [34]. This conversion is
mediated by beta-glucosidase, an enzyme found predominantly in the gastrointestinal
tract. This particular enzyme is released by rapidly dividing cancer cells.
Phase I biotransformation of both Hypoxoside and rooperol likely occurs via the P450
system and most likely by CYP 3A4 [35]. A multi-dosage trial found only diglucuronide,
disulphate, and mixed glucuronide-sulphate metabolites of these two principal constituents
in the serum of recipients. Elimination of the metabolites follows first order kinetics with
half lives ranging from 20 hours for the two minor metabolites (i.e., diglucuronide and
disulphate), to 50 hours for the major metabolite (i.e., the mixed glucuronide-sulphate)[22].
Our group recently reported Hypoxis' effect on the P-450 system CYP 3A4 enzyme, the
drug transporter P-glycoprotein (P-gp), and the pregnane X receptor (PXR) [35]. Hypoxis
inhibited up to 86% of the normal CYP 3A4 isoform activity. P-glycoprotein showed
moderate activity from exposure to Hypoxis, showing 4251% of the activity strength
relative to the known P-gp inhibitor verapamil. Exposure to Hypoxis resulted in an almost
2-fold activation of the PXR (p < 0.05). This activation was dose-dependent. Whilst the
concentrations used in the in vitro experiments were relatively high, the study nevertheless
demonstrated that Hypoxis possesses the potential to interact with HIV drug metabolizing
enzymes, which could subsequently lead to drug resistance, drug toxicity and/or treatment
failure. It should be noted, however that this evidence is only from one in vitro model and
may not translate to the same effect in vivo.
Toxicity
A Phase I trial in cancer patients failed to establish any clinical, hematological, or
biochemical toxicities that could be ascribed to the ingestion of hypoxoside [24]. One
recipient did experience an episode of anxiety, nausea, vomiting and diarrhea which was
possibly hypoxoside related. The data and safety monitoring committee recently
terminated a clinical trial of therapeutic effectiveness in HIV/AIDS patients citing apparent
bone marrow suppression [36]. Supporters of this herbal medicine have disputed these
inferences [37].

Hypoxoside, when infused in anaesthetized chacma baboons, had no effect on the

cardiovascular system, whereas rooperol exerted moderate stimulation during drug
administration. The cardiac output increased together with systemic and pulmonary arterial
pressures and these changes were not accompanied by changes in heart rate, vascular
resistances or in the filling pressures of the heart. These findings are suggestive of
increased myocardial contractility, possibly related to rooperol's catechol structure. It is
likely that these cardio stimulatory effects will prove to be clinically benign [22]. The
molecular basis of rooperol toxicity still needs to be clarified. Biochemical studies have
shown that rooperol is a potent inhibitor of leukotriene synthesis in polymorphonuclear
leucocytes at a concentration of 1 M or less [22].
Sutherlandia Frutescens subspecies Microphylla
Common names
Insiswa, Unwele, Mukakana, Phetola, Lerumo-lamadi, cancer bush, kankerbos,
kankerbossie [38,39]
Background
The flowering shrub S. frutescens is a member of the Fabacea family. The recommended
therapeutic dose of Sutherlandia in humans is 9 mg/kg/day[40]. Sutherlandia has been
used in the treatment of cancer, tuberculosis, diabetes, chronic fatigue syndrome,
influenza, rheumatoid arthritis, osteoarthritis, peptic ulcers, gastritis, reflux esophagitis,
menopausal symptoms, anxiety, clinical depression and HIV infection [38,39]. The South
African Ministry of Health has concluded that this product is safe based on primate safety
studies.
However, scientific data relating to the mechanism whereby Sutherlandia acts on the
immune system has not been comprehensively documented. Fernandes et al [41] recently
described the antioxidant potential of Sutherlandia frutescens where extracts from hot
water possessed superoxide as well as hydrogen peroxide scavenging activities which
could account for anti-inflammatory properties. In a study by Tai et al, [42] ethanolic
extracts were shown to have an anti-proliferative effect on several human tumor cell lines
but did not show significant antioxidant activity.

Phyto Nova, of South Africa, is the principal distributor of both the powdered and
encapsulated forms of this herb, and has attempted to evaluate the purported benefits of
this remedy in HIV/AIDS treatment[38]. A definitive conclusion has not yet been reached.
Despite the paucity of data, the South African Ministry of Health and member states
currently recommend the use of this herbal remedy for HIV/AIDS treatment[17,40].
Constituents
The principal constituents of S. frutescens purported to be active include L-canavanine,
GABA, and D-pinitol. L-canavanine is a non-protein amino acid that is the L-2-amino-4guanidinooxy structural analogue of L-arginine. There is about 3040 mg of L-canavanine
per dry gram of the S. frutescens leaf[38]. D-pinitol is a type of sugar found in many types
of legumes and is classified as a chiro-inositol. It is also known as 3-O-methyl-D-chiroinositol, or 3-0-methyl-1,2,4 cis-3,5,6 trans-hexahydroxy-cyclohexanol. GABA (gabbaamino butyric acid) is both an amino acid and inhibitory neurotransmitter. It is found at
levels of 14 mg per gram dry leaf of S. frutescens[38].
One of the chemical constituents of Sutherlandia, L-canavanine, is an arginine analogue.
L-canavanine has been reported to have anti-viral activity against influenza and
retroviruses, including HIV [43]. A US patent registered in 1988 claimed that 95% of HIVinfected lymphocytes were selectively destroyed in vitro. Unfortunately, no further studies
of the effect of this herb on HIV have confirmed this claim. D-pinitol another important
constituent of Sutherlandia has also been suggested for the treatment of wasting in cancer
and AIDS patients although evidence is scant[44].
Pharmacokinetics and pharmacology
The pharmacokinetic properties of Sutherlandia have largely not been assessed[40]. We
have demonstrated in vitro effects of Sutherlandia on CYP3A4, P-gp, and PXR [35].

Sutherlandia produced near complete inhibition of CYP3A4 (96%). P-gp activity was
moderate under exposure of Sutherlandia, showing 1931% of the activity strength relative
to verapamil. A PXR assay demonstrated a greater than 2-fold activation with exposure to

Sutherlandia which was dose-dependent (P < 0.01). Once again, in spite of the relatively
high concentrations used in the in vitro experiments, these results tentatively suggest that

human consumption of Sutherlandia could affect antiretroviral drug metabolism leading to

bi-directional drug interactions and loss of therapeutic efficacy. In vivo human studies are
required to determine if there is a clinically relevant drug/herb interaction and if so what the
true extent of the interaction is.
Toxicity

Sutherlandia has a relatively long history of seemingly safe usage in Africa. Known side
effects include occasional mild diarrhea, dry mouth, mild diuresis, and dizzyness in
cachectic patients [38,39]. An extensive toxicology screening in a primate model using
dosages up to 9 times greater than the recommended dose of 9 mg/kg/day did not identify
clinical, hematological or physiologic toxicity with Sutherlandia [45].
L-canavanine may be associated with important toxicities including a systemic lupus
erythematous syndrome [46]. The non-protein amino acid can be incorporated into protein
in place of arginine and may, after long term usage, result in autoimmunity [47,48]. Rare
reports of teratogenicity and induction of abortion exist [49].

Discussion
The widespread use of herbal compounds by Africans living with HIV/AIDS should be of
concern to clinicians and policy makers. Clearly, patients will continue to access traditional
healing systems as it is important to local cultural values and beliefs. Therefore, efforts
should be made by mainstream health professionals to provide validated information to
traditional healers and patients on the judicious use of herbal remedies. This may reduce
harm through failed expectations, pharmacologic adverse events and unnecessary added
therapeutic costs. Efforts should also be directed at evaluating the possible benefits of
natural products in HIV treatment.
It is not unreasonable to suggest that some products may have therapeutic benefits as
examples from history and the recent past have provided us with effective anti-malarials
[50] and cancer treatments[51]. Indeed, some of the earliest forms of protease inhibitors
were derived from natural products [52-54]. Efforts should be directed at determining the
therapeutic efficacy of these remedies as well as the possibility of interactions through
systematic research and clinical trials.

Several studies have highlighted key problems related to primary care delivery by
traditional healers in Africa [8,55,56]. Key issues include hygiene, toxicity and financial
cost. Traditional healers have been implicated in the spread of blood borne diseases
including HIV and other infectious disease by the re-use of medical instruments and lack of
hand washing [8,55,56]. Prescriptions to take toxic plants for HIV treatment have also
resulted in severe adverse events, including death[56]. Recent policy efforts have
recognized the substantial use of traditional medicines and several African nations have
included traditional healers in educational campaigns in order to instruct them on safe and
hygienic practices, condom distribution and knowledge dissemination[2,5,6,14,57].
Despite the relatively high concentrations of herbals used in our in vitro work, the results
serve as a warning and suggest that biologically active constituents of these herbal
remedies clearly may have an effect on HIV drug metabolism as a result of their inhibitory
activity on enzymes and efflux drug transporter systems. These results highlight the need
for in vivo investigations and circumspection when utilizing herbal drugs as routine care for
HIV patients and underscores the need for clinical studies in humans to unveil any
possible drug interaction of these herbal agents with antiretrovirals. Failure to do this may
result in bi-directional drug interactions that may put patients at risk for treatment failure,
viral resistance or drug toxicity.
Cultural values are an inherent part of healthcare and an important component of
practicing evidence-based healthcare [58]. In the context of HIV treatment in Africa,
patients often choose traditional healing systems as primary care. This, coupled with the
difficulties in accessing antiretroviral treatment, justify further efforts to determine the
scope of traditional medicine use, identify the negative consequences of this practice and
evaluate the benefits of herbal remedies. In addition, it is important to understand the
values of those providing mainstream healthcare and those practicing traditional medicine
as their perspectives provide highly relevant social inferences and should be interpreted
with an attempt to understand their cultural worldviews and practices.
In conclusion, given the Global Fund's recent announcement of funds to make antiretroviral therapy widely available in Africa, and the South African Ministry of Health, along
with member states and NGO's endorsement of the use of traditional African herbs such
as Hypoxis and Sutherlandia as HIV/AIDS remedies [17], initiating policy on herbal

medicines should be based on research evidence. Efforts are required to determine the
safety, efficacy and pharmacological profile of the many herbal compounds used in Africa.
Collaboration with traditional healers is justified to fully understand what remedies are in
use for HIV and to educate those providing alternative medical services against unsafe
practices.

References
1. Fairfield KM, Eisenberg DM, Davis RB, Libman H, Phillips RS: Patterns of use,
expenditures, and perceived efficacy of complementary and alternative therapies in
HIV-infected patients.

Arch Intern Med 1998 , 158:2257-2264. PubMed Abstract | Publisher Full Text
Return to text

2. Babb DA, Pemba L, Seatlanyane P, Charalambous S, Curchyard G, Grant AD: Use

of traditional medicine in the era of antiretroviral therapy: experience from South
Africa.

eJIAS 2004, MedGenMed 2004 , 6:B10640.

[eJIAS. 2004 Jul 11;1(1):B10640].
Return to text

3. Colebunders R, Dreezen C, Florence E, Pelgrom Y, Schrooten W: The use of

complementary and alternative medicine by persons with HIV infection in Europe.

Int J STD AIDS 2003 , 14:672-674. PubMed Abstract | Publisher Full Text
Return to text

4. Duggan J, Peterson WS, Schutz M, Khuder S, Charkraborty J: Use of

complementary and alternative therapies in HIV-infected patients.

AIDS Patient Care STDS 2001 , 15:159-167. PubMed Abstract | Publisher Full Text
Return to text

5. Fleming J: Mozambican healers join government in fight against AIDS.

J Int Assoc Physicians AIDS Care 1995 , 1:32. PubMed Abstract

Return to text

6. Homsy J, King R, Balaba D, Kabatesi D: Traditional health practitioners are key to

scaling up comprehensive care for HIV/AIDS in sub-Saharan Africa.

Aids 2004 , 18:1723-1725. PubMed Abstract | Publisher Full Text

Return to text

7. McMillen H: The adapting healer: pioneering through shifting epidemiological and

sociocultural landscapes.

Soc Sci Med 2004 , 59:889-902. PubMed Abstract | Publisher Full Text
Return to text

8. Peters EJ, Immananagha KK, Essien OE, Ekott JU: Traditional healers' practices
and the spread of HIV/AIDS in south eastern Nigeria.

Trop Doct 2004 , 34:79-82. PubMed Abstract

Return to text

9. Ernst E: Heavy metals in traditional Indian remedies.

Eur J Clin Pharmacol 2002 , 57:891-896. PubMed Abstract | Publisher Full Text
Return to text

10. Ernst E: Toxic heavy metals and undeclared drugs in Asian herbal medicines.

Trends Pharmacol Sci 2002 , 23:136-139. PubMed Abstract | Publisher Full Text
Return to text

11. Ernst E, Thompson Coon J: Heavy metals in traditional Chinese medicines: a

systematic review.

Clin Pharmacol Ther 2001 , 70:497-504. PubMed Abstract

Return to text

12. Morris K: South Africa tests traditional medicines.

Lancet Infect Dis 2002 , 2:319. PubMed Abstract | Publisher Full Text
Return to text

13. Wittenstein B, Rogers V, Novelli V, Clayton PT, Kenny MB, Peters MJ: "African
medicine" and Reye's syndrome.

Lancet 2004 , 363:860. PubMed Abstract | Publisher Full Text

Return to text

14. MacPhail CL, Campbell CM, Pitts M: Operationalizing the dual use of traditional and
Western health care for STIs and HIV.

XIV International AIDS Conference: 2002; Barcelona: MoPeB3209 2002.

Return to text

15. Sebit MB, Chandiwana SK, Latif AS, Gomo E, Acuda SW, Makoni F, Vushe J:
Quality of life evaluation in patients with HIV-I infection: the impact of traditional
medicine in Zimbabwe.

Cent Afr J Med 2000 , 46:208-213. PubMed Abstract

Return to text

16. Zachariah R, Nkhoma W, Harries AD, Arendt V, Chantulo A, Spielmann MP,

Mbereko MP, Buhendwa L: Health seeking and sexual behaviour in patients with
sexually transmitted infections: the importance of traditional healers in Thyolo,
Malawi.

Sex Transm Infect 2002 , 78:127-129. PubMed Abstract | Publisher Full Text
Return to text

17. SADC: SADC Ministerial Consultative meeting on Nutrition and HIV/AIDS.

Johannesburg
20 January 2002
Return to text

18. ARV roll-out begins today

[http://www.sundaytimes.co.za/zones/sundaytimes/newsst/newsst1080795554]
webcite

Sunday Times (South Africa)

March 1 2003
Return to text

19. Giraldo R: Brief report. [http://www.laleva.cc/choice/aids/aids_giraldo.html]

webcite

SOUTHERN AFRICAN DEVELOPMENT COMMUNITY (SADC) MEETING ON

NUTRITION AND HIV/AIDS: 2002; Johannesburg 2002.
Return to text

20. Snijman D: Hypoxidacea: cape plants a conspectus of the cape flora of South
Africa.

Strelitzia 2000 , 9:108-110.

Return to text

21. Singh Y: Hypoxis: yellow stars of horticulture, folk remedies and conventional
medicine.

Veld & Flora 1999 , 85:123-125.

Return to text

22. Albrecht CF, Kruger PB, Smit BJ, Freestone M, Gouws L, Miller R, van Jaarsveld
PP: The pharmacokinetic behaviour of hypoxoside taken orally by patients with lung
cancer in a phase I trial.

S Afr Med J 1995 , 85:861-865. PubMed Abstract

Return to text

23. Wilt TJ, Ishani A, Rutks I, MacDonald R: Phytotherapy for benign prostatic
hyperplasia.

Public Health Nutr 2000 , 3:459-472. PubMed Abstract

Return to text

24. Smit BJ, Albrecht CF, Liebenberg RW, Kruger PB, Freestone M, Gouws L, Theron
E, Bouic PJ, Etsebeth S, van Jaarsveld PP: A phase I trial of hypoxoside as an oral
prodrug for cancer therapy absence of toxicity.

S Afr Med J 1995 , 85:865-870. PubMed Abstract

Return to text

25. Mahomed IM, Ojewole JA: Hypoglycemic effect of Hypoxis hemerocallidea corm
(African potato) aqueous extract in rats.

Methods Find Exp Clin Pharmacol 2003 , 25:617-623. PubMed Abstract | Publisher
Full Text
Return to text

26. Bouic PJ, Clark A, Brittle W, Lamprecht JH, Freestone M, Liebenberg RW: Plant
sterol/sterolin supplement use in a cohort of South African HIV-infected patients
effects on immunological and virological surrogate markers.

S Afr Med J 2001 , 91:848-850. PubMed Abstract

Return to text

27. Bouic PJ, Clark A, Lamprecht J, Freestone M, Pool EJ, Liebenberg RW, Kotze D,
van Jaarsveld PP: The effects of B-sitosterol (BSS) and B-sitosterol glucoside
(BSSG) mixture on selected immune parameters of marathon runners: inhibition of
post marathon immune suppression and inflammation.

Int J Sports Med 1999 , 20:258-262. PubMed Abstract

Return to text

28. Bouic PJ, Etsebeth S, Liebenberg RW, Albrecht CF, Pegel K, Van Jaarsveld PP:
beta-Sitosterol and beta-sitosterol glucoside stimulate human peripheral blood
lymphocyte proliferation: implications for their use as an immunomodulatory vitamin
combination.

Int J Immunopharmacol 1996 , 18:693-700. PubMed Abstract | Publisher Full Text

Return to text

29. Whitney JR, Billoski TV, Jones VR: Evidence for Triceratops in Antarctica. In New

Directions in Paleontology. Edited by: Billoski TV. New York: Academic Press;
1997:24-27.
Return to text

30. "I read it in the paper" Spud magic?

THE SA RETAIL CHEMIST

1997, 1 AUGUST
Return to text

31. Sengupta SSR, DeVillis R, Crouse Quinn S, DeVillis B, Ware WB: Factors Affecting
African-American Participation in AIDS Research.

JAIDS 2000 , 24:275-284. PubMed Abstract

Return to text

32. Aids conference starts [http:/ / www.news24.com/ News24/ South_Africa/

Aids_Focus/ 0,2-7-659_1396465,00.html]

webcite

33. Albrecht CF, Theron EJ, Kruger PB: Morphological characterisation of the cellgrowth inhibitory activity of rooperol and pharmacokinetic aspects of hypoxoside as
an oral prodrug for cancer therapy.

S Afr Med J 1995 , 85:853-860. PubMed Abstract

Return to text

34. Dietzsch E, Albrecht CF, Parker MI: Effect of rooperol on collagen synthesis and
cell growth.

IUBMB Life 1999 , 48:321-325. PubMed Abstract

Return to text

35. Mills EJ, Foster BC, van Heeswijk RP, Wilson K, E P, Kosuge K, Leonard B, Kanfer
I: Impact of African herbal medicines on antiretroviral metabolism.

AIDS 2005 , 19:95-7. PubMed Abstract | Publisher Full Text

Return to text

36. Terreblanche C: HIV warning on African potato. [http:/ / www.iol.co.za/

index.php?sf=125&click_id=31&art_id =vn20030715134316530C349682&set_id= 1]
webcite

IOL 2003.
Return to text

37. Clarke L: African potato gets bum rap as vital remedy. [http:/ / www.iol.co.za/
index.php?set_id=1&click_id=31&art_ id=ct20030726175801155P4532454]

webcite

Sunday Independent 2003.

Return to text

38. Gericke N, Albrecht CF, Van Wyk B, Mayeng B, Mutwa C, Hutchings A:

Sutherlandia frutescens.

Australian Journal of Medical Herbalism 2001 , 13:9-15. Publisher Full Text

Return to text

39. Dalvi S: Sutherlandia for immune support.

Positive Health 2003 , 23-25.

Return to text

40. Seier JV, Mdhuli M, Dhansay MA, Loza J, Laubschner R, Matsabisa G: A toxicity
study of Sutherlandia leaf powder (sutherlandia microphylla) consumption.
[http://www.sahealthinfo.org/traditionalmeds/cancerbush2.pdf]

webcite

South African Ministry of Health Document 2002.

Return to text

41. Fernandes AC, Cromarty AD, Albrecht C, van Rensburg CE: The antioxidant
potential of Sutherlandia frutescens.

J Ethnopharmacol 2004 , 95:1-5. PubMed Abstract | Publisher Full Text

Return to text

42. Tai J, Cheung S, Chan E, Hasman D: In vitro culture studies of Sutherlandia

frutescens on human tumor cell lines.

J Ethnopharmacol 2004 , 93:9-19. PubMed Abstract | Publisher Full Text

Return to text

43. Green M: Method of treating viral infections with amino acid analogue.

US Patent 5110,600
Jan 25 1988.
Return to text

44. Oslund R, Sherman W: Pinotol and derivatives thereof for the treatment of
metabolic disorders. US Patent. 5,882,896. March 4, 1996.
45. A toxicity study of Sutherlandia leaf powder (sutherlandia microphylla) consumption
[http://www.saheatlhinfo.org/traditionalmeds/cancerbush2.pdf]

webcite

46. Capasso R, Izzo AA, Pinto L, Bifulco T, Vitobello C, Mascolo N: Phytotherapy and
quality of herbal medicines.

Fitoterapia 2000 , 71(Suppl 1):S58-65. PubMed Abstract | Publisher Full Text

Return to text

47. Prete PE: Effects of L-canavanine on immune function in normal and autoimmune
mice: disordered B-cell function by a dietary amino acid in the immunoregulation of
autoimmune disease.

Can J Physiol Pharmacol 1985 , 63:843-854. PubMed Abstract

Return to text

48. Prete PE: The mechanism of action of L-canavanine in inducing autoimmune

phenomena.

Arthritis Rheum 1985 , 28:1198-1200. PubMed Abstract

Return to text

49. Van Wyk B, Gericke N: People's plants a guide to the useful plants in South
Africa.

Pretoria: Briza 2000.

Return to text

50. Adjuik M, Babiker A, Garner P, Olliaro P, Taylor W, White N: Artesunate

combinations for treatment of malaria: meta-analysis.

Lancet 2004 , 363:9-17. PubMed Abstract | Publisher Full Text

Return to text

51. Slichenmyer WJ, Von Hoff DD: Taxol: a new and effective anti-cancer drug.

Anticancer Drugs 1991 , 2:519-530. PubMed Abstract

Return to text

52. Egberg DC, Potter RH, Honold GR: The semiautomated determination of trypsin
inhibitors in textured soy protein.

J Agric Food Chem 1975 , 23:603-605. PubMed Abstract | Publisher Full Text
Return to text

53. Egeblad K: Effects of soy bean trypsin inhibitor on fibrin clot lysis.

Thromb Diath Haemorrh 1966 , 15:542-553. PubMed Abstract

Return to text

54. Rabek V, Mansfield V: Gel filtration of protease inhibitors from potatoes.

Experientia 1963 , 19:151-152. PubMed Abstract

Return to text

55. Miles SH, Ololo H: Traditional surgeons in sub-Saharan Africa: images from south
Sudan.

Int J STD AIDS 2003 , 14:505-508. PubMed Abstract | Publisher Full Text
Return to text

56. Munk K: Traditional healers, traditional hospitals and HIV / AIDS: a case study in
KwaZulu-Natal.

AIDS Anal Afr 1997 , 7:10-12. PubMed Abstract

Return to text

57. Sidley P: South Africa to regulate healers.

BMJ 2004 , 329:758. PubMed Abstract | Publisher Full Text

Return to text

58. Haynes RB, Devereaux PJ, Guyatt GH: Physicians' and patients' choices in
evidence based practice.

BMJ 2002 , 324:1350. PubMed Abstract | Publisher Full Text

Return to text
More information about controversial AIDS books.
VIRUSMYTH HOMEPAGE

BOOKSHELF

Robert E. Willner, 'Deathly Deception' Peltec Publishing Co. USA 1994, 266
pages, ISBN 0-9642316-1-1.

In 1993, Dr. Willner stunned Spain by inoculating himself with the blood of
Pedro Tocino, an HIV positive hemophiliac. This demonstration of devotion
to the truth and the Hippocratic Oath he took, nearly 40 years before, was
reported on the front page of every major newspaper in Spain. His
appearance on Spain's most popular television show envoked a 4 to 1
response by the viewing audience in favor of his position against the "AIDS
hypothesis." When asked why he would put his life on the line to make a
point, Dr. Willner replied: "I do this to put a stop to the greatest murderous
fraud in medical history. By injecting myself with HIV positive blood, I am
proving the point as Dr. Walter Reed did to prove the truth about yellow
fever. In this way it is my hope to expose the truth about HIV in the interest of
all mankind."
In Deadly Deception Dr. Willner proves:

The AIDS hypothesis is totally fraudulent.

Its perpetrators are guilty of criminal fraud and murder!
The HIV virus does not and could not possibly cause AIDS or any serious
disease.
AIDS is not transmitted sexually nor is it contagious by any method!

Each day healthy individuals continue to be diagnosed "positive" by a totally

inaccurate HIV test. They are then treated for an imaginary, non-existent
disease with AZT (Zidovudine) - the drug that was shelved because it was
too toxic to treat cancer! AZT actually causes Acquired Immune Deficiency
Syndrome and thereby fulfils the prophecy of death by "AIDS.
Backed by scientific and factual proof you learn the truth:

What really causes AIDS, how it can be avoided and even cured.
How the HIV test can be positive because of having a simple "Flu"
vaccination, the measles or many other common infections!
Why AIDS is not an epidemic but a total myth based on false projections and
disproved by time and the statistics.
Why the homosexual community erroneously became identified as AIDS
carriers.

Why AIDS is a syndrome and not a transmittable disease.

Why 25 to 30 diseases were, for the first time in recorded history, lumped
together under a new name in an attempt to give the appearance of an
epidemic!
Acquired Immune Deficiency is not new; it has been known and written
about in medical books for almost seventy years.

All of this and much, much more are revealed in: Deadly Deception!

Article from The Washington Post

Article from the Charlotte Observer.
Article by the author.
VIRUSMYTH HOMEPAGE

Dr ROBERT E. WILLNER M.D., Ph.D.

[back] Cancer Industry critics

[Dr Willner (a medical doctor of 40 years experience) was the author of The Cancer
Solution & Deadly Deception, and an outspoken whistleblower of the AIDS hoax. He
appeared on Spanish TV where he mixed his blood with the blood of an HIV positive man
to demonstrate his belief that HIV was not the cause of AIDS. His suggested prime
therapies were Budwig Diet, Chelation therapy, Laetrile, Ozone therapy, Pulsed Magnetic
therapy, 714X, Glyoxide, Proteolytic enzymes, rectal Coffee instillation, Colonic cleansing,
Mind-spiritual support, Therapeutic vitamin/minerals. Died afore his time like many critics
of Allopathy Inc.]
CURRICULUM VITAE
Dr Sodi Pallares
The Budwig Diet by Robert Willner, M.D., Ph.D.
The Beginning of the End (The Needle Stick)

[1994] DOCTOR PUTS WIDELY DISPUTED AIDS VIEW ON DISPLAY HE SAYS HIV
NOT CAUSE; NONSENSE, SAY OTHERS
[1994] Interview

Books
Deadly Deception by Robert E. Willner M.D., Ph.D.
The Cancer Solution by Robert E. Willner M.D., Ph.D.

Quotes
"My opinion, however, is that they (herbs) are superior 95% of the time to any
pharmaceutical drug!"---Willner, M.D.
"During the last 10 years of my practice I utilised many therapies that were not in the
mainstream of medicine. they were safe, non-toxic and very effective. When I retired I
travelled and researched other therapies...I spoke with many doctors and patients who
were getting excellent results from these alternative therapies and witnessed their success
first hand. It is time to seriously question and reject the standard orthodox cancer
treatments of surgery, radiation and chemotherapy, except in a very few instances.
You may have difficulty in obtaining some of these therapies..because the FDA has
literally pressured Congress, under the guise of protecting the public, to keep timehonoured cultural and natural therapies out of the hands of the general public. If you look
at the record of the FDA, it becomes obvious they are serving interessts other than yours
and mine
The 'cancer establishment' is a network of extremely powerful and wealthy
companies whose members sit on the boards of many non-profit organisations. They
literally control and direct all cancer research within the USA and throughout the
world......Although these centres are non-profit they serve their masters by suppressing
most, if not all, non-patentable treatments in favour of the expensive treatments therapies
that have wrought havoc with patients while losing the war against cancer."---Deadly
Deception by Dr Willner

"The anti-cancer effect of

amygdalin was demonstrated in
Mexico by government sponsored
reserach under Dr. Mario Soto De
Leon and its use is legal. Dr Soto
was the first medical director of the
Cydel Clinic in Tijuana (taken over by Dr Manner) .It is very important that it be prepared
and administred correctly in sufficient dosage or it will not be effective. The trial performed
at the Mayo Clinic in the early 80's involved the use of the racemic mixture rather than the
levo-rotary form and thus was only 10% of the strength required. In spite of this, towards
the end of the experiment, the patients began to show improvement, but it was
discontinued and declared ineffectual."--Deadly Deception by Dr Willner
Doctors truly believe that they have a monopoly on "state of the art" weapons at their
disposal, and that all other approaches are the products of ignorance or downright fraud.
This inbred arrogance and ignorance has hindered the advance of good medical practice
more than any other factor -I know, I once believed in the same myth. Deadly Deception
by Dr Willner
The second reason lies in the economic comforts and privilege that this allopathic medical
monopoly provides. The Physician has enjoyed a unique status of wealth, power and
prestige, unchallenged until recent years. The public is becoming educated and medicine
has failed to deliver on one promise after another. Having spent close to forty years in
medicine, I know that there are very few physicians who perpetuate the myth knowingly.
The rewards tend to dull one's ability to be critical. It is also very difficult to challenge or
search for the flaws in the basic meaning of an entire life's work. Can you imagine looking
back and having to say to yourself, "I did it all wrong!" ? Deadly Deception by Dr Willner
Lastly, we have a corrupt, self-serving and often inept government bureaucracy that
protects these special powerful interests. They can be vicious and fanatic in their
zealousness. The result: pain and suffering, needless deaths and a waste of resources

beyond imagination, which has been the greatest single contributing factor responsible for
the huge national debt threatening to cripple our nation. Deadly Deception by Dr Willner
Chelation has not only improved heart disease, stroke, high blood pressure, arthritis,
Parkinson's and Alzheimer's disease, but also, Studies indicate a 50% reduction in the
occurrence of cancer in individuals who have received EDTA! Chelation has been reported
to improve asthma, emphysema, brain function, muscular coordination, Multiple Sclerosis
and impotence Deadly Deception by Dr Willner
I spent several days in Freudenstadt visiting Dr. Budwig and each evening I returned to my
hotel with papers she gave me to read. In one of the papers, where she referred to the
work of Szent-Gyorgi and Popp, it stated that they both mentioned growth regulation in the
red field of light. That information was based on the work that Dr. Budwig had done
involving her use of ruby laser (laser in the red spectrum of light) in the treatment of cancer
and its relationship to the fatty acids. This especially interested me, because I had
performed the world's first double-blind study on the use of low power helium neon and
infrared laser, both in the red spectrum of light, which demonstrated definite therapeutic
benefit in the treatment of arthritis of the hands. My paper was presented at the highly
respected World Congress of Pain (1984) in Seattle, Washington. This carefully controlled
scientific study, using an extremely safe level of laser light similar to that used to read
labels on products in millions of stores throughout the world, was repeated and confirmed
by two fully accredited, well-known American universities. The FDA has not given the
needed recognition to these studies that would make this therapy readily available and
reimbursable by health insurance. This inexpensive, completely safe therapy would
naturally pose a serious threat to the multi-billion dollar market in the potentially dangerous
anti-inflammatory steroidal and non-steroidal drugs. These drugs comprise the largest,
most profitable segment of drug sales. Deadly Deception by Dr Willner
I listened to the cases of physicians who brought their family members for successful nonestablishment treatments, but renounced and refused those same remedies to their
patients. I was angered at one story about a physician who had treated a child with
leukemia with non-toxic natural remedies and was brought to court by the medical

establishment. The parents had refused chemotherapy from another doctor and had
requested the alternative therapy from the doctor who was now being charged with
depriving the child of proper medical treatment. The child survived the same amount of
time she would have on chemotherapy, without any of the debilitating, painful and
dehumanizing effects. Deadly Deception by Dr Willner
Establishment medicine, with little or no evidence to support their barbaric use of these
highly toxic drugs, continues to make fortunes while their patients spend their last days
vomiting, debilitated, baldheaded and without dignity. While patients suffer from "cutting
edge" therapy, the physician places his head comfortably on his pillow at night, content
that he has served humanity with the best "anyone" has to offer. His dreams and his
waking hours know nothing of the other world out there that has existed for five thousand
years. Besides, how dare anyone suggest that a tribal medicine man or a dissident
colleague could accomplish more. It is incredible to me that physicians could accept the
fact that a single artificial chemical compound created in a laboratory could cure or control
a disease and reject the idea that a natural food, with its many chemical compounds, could
do the same or infinitely better.
S. Fukushima, Nagoya City University Medical School -Demonstrated that 5 times the
vitamin C dose recommended by Pauling could accelerate the effects of bladder cancer.
He originally used the sodium form of vitamin C, but then later reported that the same
extremely high dose of ordinary ascorbic acid did not have an adverse effect on bladder
cancer! Deadly Deception by Dr Willner
In spite of all the claims that vitamin C promotes kidney stones, D. du Bruyn demonstrated
that very high doses of ascorbic acid over a 20 months period did not cause any
deposition of crystals (stones) in 16 baboons. Deadly Deception by Dr Willner
Vitamin D requires exposure to sunlight in order to be manufactured by the body. The
Garland brothers proposed that sunlight is actually protective against the dreaded skin
cancer, malignant melanoma. This is of course contrary to what is commonly thought
about cancers of the skin and sunlight. Their premise was based on the fact the
melanomas occurred mostly in sailors who worked indoors and far less in those who

worked outdoors. Laboratory work had already shown that vitamin D suppressed
melanoma growth! Their findings are represented in the Archives of Environmental Health,
1990. Deadly Deception by Dr Willner
Ovarian cancer responded three times better to Iscador than to standard chemotherapy
involving Cytobal (W. Hassauer, et al., Onkologie, 1979). No wonder the American Cancer
Society condemned it! Deadly Deception by Dr Willner
As an interesting addition to the on-going expose of the great AIDS-AZT fraud, documents
of the National Cancer Institute in 1991 revealed that Maitake mushrooms were as
effective in inhibiting the growth of the so-called HIV virus equally as well as the toxic killer
drug AZT. Incredibly, the National Cancer Institute converted the natural Maitaki extract
into a sulphate and thus rendered it toxic. AZT continues to make billions for the Wellcome
Company, while committing mass murder. Other mushroom products have been
obstructed by the FDA in spite of the fact that they have proved effective against cancer in
other parts of the world. PSK, widely used throughout the world, has been blocked by the
FDA. (You are better off with the Maitake mushroom itself, so, Bon appetit!) Deadly
Deception by Dr Willner
Dr. Max Gerson takes his place of honor in the history of modern medicine because he
has, like many other notable physicians, been attacked by the American Medical
Association. It will be recorded one day, that if you wish to find a list of scientists who have
truly contributed most to the development of effective non-toxic therapies, you simply have
to look at a list of the victims of AMA treachery and viciousness (fostered by the
pharmaceutical industry and aided and abetted by our unfaithful servants at the FDA). Max
Gerson's "crime" was that he advocated the use of coffee enemas which, surprisingly, has
a scientific rationale and is based on research done in Germany in the 1920's. It could
even be found in the Merck Manual during its first twenty years of publication. The
American Medical Association, in its usual attitude of arrogance and ignorance, claimed
that there was no scientific evidence that the "modification of the dietary intake of food or
other nutritional essentials was of any specific use in the control of cancer." Today the

AMA still lobbies the United States Congress as the

outstanding authority on what is good for the health of
the American public. Deadly Deception by Dr Willner

The Budwig Diet by Robert Willner, M.D., Ph.D. (author of The Cancer Solution)
Six time nobel award nominated doctor says this essential nutrient combination actually
prevents and cures cancer!

A top European cancer research scientist, Dr Johanna Budwig, has discovered a totally
natural formula that not only protects against the development of cancer but people all
over the world who have been diagnosed with incurable cancer and sent home to die have
actually been cured and now lead normal healthy lives.
After three decades of research Dr. Budwig, six-time nominee for the Nobel Award, found
that the blood of seriously ill cancer patients was always, without exception, deficient in
certain important essential ingredients which included substances called phosphatides and
lipoproteins. (The blood of a healthy person always contains sufficient quantities of these
essential ingredients. However, without these natural ingredients cancer cells grow wild
and out of control.)
Blood analysis showed a strange greenish-yellow substance in place of the healthy red
oxygen carrying hemoglobin that belongs there. This explained why cancer patients
weaken and become anemic This startling discovery led Dr. Budwig to test her theory.
She found that when these natural ingredients where replaced over approximately a three
month period, tumors gradually receded. The strange greenish elements in the blood were
replaced with healthy red blood cells as the phosphatides and lipoproteins almost
miraculously reappeared. Weakness and anemia disappeared and life energy was
restored. Symptoms of cancer, liver dysfunction and diabetes were completely alleviated.
Dr. Budwig then discovered an all natural way for people to replace those essential
ingredients their bodies so desperately needed in their daily diet. By simply eating a
combination of just two natural and delicious foods not only can cancer be prevented but in
case after case it was actually cured. (These two natural foods, organic flax seed oil &
cottage cheese) must be eaten together to be effective since one triggers the properties of
the other to be released.)
After more than 10 years of solid clinical application, Dr. Budwig's natural formula has
proven successful where many orthodox remedies have failed. Dr. Budwig's formula has
been used therapeutically in Europe for prevention of: Cancer! Arteriosclerosis, Strokes,
Cardiac Infarction, Heartbeat (irregular), Liver (fatty degeneration), Lungs (reduces

bronchial spasms), Intestines (regulates activity). Stomach Ulcers (normalizes gastric

juices), Prostate (hypertopic), Arthritis (exerts a favorable influence), Eczema (assists all
skin diseases), Old age (improves many common afflictions), Brain (strenghthens activity),
Immune Deficiency Syndromes (multiple sclerosis, auto-immune illnesses)
Thousands have flocked 10 hear Dr. Budwig lecture all over Europe. The many people Dr.
Budwig's formula has helped testify to the benefits of her remarkable discovery. Following
are a few examples: In one of my interviews with Dr. Budwig I was introduced to Siegried
Ernst, M.D.. He is a rare and dedicated man who counts among his personal friends the
current Pope as well as many other dignitaries.
Seventeen years ago Dr. Ernst had developed cancer for which he had major surgery
requiring removal of his stomach. Two years later he had a recurrence of the cancer and
was offered chemotherapy as the only available remedy. There was little hope for survival
as virtually all individuals with recurrence of this type of cancer rarely last a year.
Dr. Ernst knew that chemotherapy was not only ineffective for his type of cancer but
completaly destructive of the quality of life, so he refused.
He turned to Dr. Budwig and her formula for help. He religiously followed Dr. Budwig's
formula and fifteen years later has not had any recurrence of cancer. As a matter of fact he
seemed to me to be in perfect health and is tireless for a man in his late seventies.
Maria W. tells her story in her own words: "I was told by the most expert of doctors that I
would have to be operated on to cut out the cancerous tumor that was causing a swelling
under my eye. They explained that the size of the tumor was much greater inside and that
there was very serious bone involvement. The malignancy was too far advanced to
respond to radiation treatment. The doctors planned to remove considerable facial tissue
and bone. I was afraid for my life, but being a young woman, couldn't bear the thought of
such disfigurement.
When I heard about Dr. Budwig's natural formula, I was skeptical but desperate for help.
After four months on this regimen, the swelling under my left eye completely disappeared.

The doctors at the University hospital gave me many exhausting tests. One told me, 'If I
didn't have your previous x-rays and medical history in front of me, I wouldn't believe that
you ever had cancer. There is hardly any indication of a tumor remaining.' I never thought
using Dr, Budwig's formula would be so successful. My whole family and I are very
grateful."
An examination of Sandy A. revealed arachnoidal bleeding due to an inoperable brain
tumor. The doctors informed Sandy that he was beyond medical help. At his expressed
wish, Sandy was discharged from the hospital and sent home to die in peace.
A friend brought Dr. Budwigs formula to Sandys attention. Sandy writes. "Since I went on
the Budwig regimen, the paralysis is of my eyes, arms, and legs has receded daily. After
only a short period of time, I was able to urinate normally. My health improved so rapidly
that I was soon able to return to my work part-time. Shortly after that, I was again
examined at the Research Center and my reflexes were completely normal. The Budwig
diet saved my life! Ten years later, I was given a thorough examination at the Center as a
follow-up. My incredible recovery has been written up In many medical journals and I have
become what they call a 'text-book case,' and all because of Dr. Johanna Budwig's simple
diet."
Seven years ago Timmy G. was diagnosed as having Hodgkins disease. The child was
operated on and underwent 24 radiation treatments, plus additional experimental therapies
that the experts hoped would be of some small help. When Timmy failed to respond
favorably to these heroic measures, he was discharged as incurable, and given six months
to live and sent home to die.
The desperate parents contacted specialists all over the world. A famous newspaper took
up Timmy's cause and ran editorials pleading for someone to come forth who could offer
hope for the life of a child. All the specialists who replied confirmed the cruel prognosis:
There was no hope or help for Timmy. At this dark hour the miracle the family had prayed
for happened! Timmy's mother told her story to the press:

"A friend sent me a printed piece about one of Dr. Budwig's speeches. This material gave
us hope and I contacted Dr. Budwig.
In just five days, (on the Budwig regimen) Timmy's breathing became normal for the first
lime In almost two years. From this day on, Timmy began to feel good again. He went
back to school, started swimming and by winter he was doing craft work. Everyone who
knows him says how well he looks." At age 18 Timmy is showing great promise in his
university work. He knows he owes his life to Dr. Budwig and thanks her daily in his
prayers.
One of the two foods in on Budwig's formula, cottage cheese, is available in nearly every
grocery store in America. The other, pure organic linseed oil, however comes primarily
from Europe and can only be found in certain health food stores throughout the United
States.
By simply mixing these two delicious foods together and eating them you will be providing
yourself and your family with the optimal preventive nutritional protection against cancer
and other disease.
The Budwig Diet