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GENOMICS; BIOL-5381/4341

Spring 2006

Genomics is a graduate level biology elective in which the fundamentals of how the human genome sequence was
acquired and the impact of the human genome era on biomedical research, medical care and genetic testing will be
explored. We will also cover new tools such as DNA microarray, realtime PCR, mass spectrometry and data mining
using bioinformatics. The class will be a mixture of didactic lectures and paper presentations representing applied
genomic approaches. Undergraduates are not required to present a paper and exams will be modified.

PREREQUISITES Biology 3301 with a Grade of C or better

TIME AND LOCATION MW 5:30 – 6:45 PM
FO 3.616

INSTRUCTOR Betty Pace, MD (bpace@utdallas.edu)
BE3. 204; Ext. 6240
OFFICE HOURS T 10-11 AM and by appointment

REQUIRED TEXT How the Human Genome Works
Edwin H McConkey
Jones and Barlett Publishers
Sudbury, MA 01776

RECOMMENDED/RESERVE TEXTS Reserve Book: Fundamental Concepts of Bioinformatics
Dan E. Krane & Michael L. Raymer
Benjamín Cummings, San Francisco CA

GRADING Four Exams (25% each), Essay Style

ACADEMIC HONESTY POLICY Students are required to abide by UT-Dallas policies concerning
academic integrity (for details, see
http://www.utdallas.edu/student
/slife/scholastic.html). Failure to comply with these terms will be
subject to appropriate disciplinary action

STUDENTS WITH DISABILITIES If you have a disability that required accommodation, you must
notify the instructor and file a request through Disability Services
(SU 1.610, ext 2098) on or before the first day of class. By doing
so, you can be assured of full cooperation in making appropriate
arrangements
CLASS SCHEDULE

Date Class # Lecture Topic Assigned Reading Pages

January
9 1 The Human Genome Project Lecture 1: 1-18
11 2 DNA/RNA Structure and Function Lecture 2: 19-34
16 - Martin Luther King Holiday NO CLASS
18 3 Human Mutations Lecture 2: 19-34
23 4 Gene Expression Reserve text, p1-12
25 5 Molecular Biology Tools Reserve text, p19-30
30 6 EXAM #1 (25%)

February
1 7 *Paper Presentation I
6 8 Genetic Diseases Lecture 3: 35-52
8 9 The Human Genome and Medicine Lecture 4: 53-68
13 10 Bioinformatics I (Dr. BU) Reserve text, p33-55
15 11 Database Searches (DR. BU)
20 12 Evolution/Phylogenetic (DR. ZEIN) Reserve text, p57-96
22 13 *Paper Presentation II
27 14 EXAM #2 (25%)

March
1 15 *Paper Presentation III
12 SPRING BREAK NO CLASS
13 16 *Paper Presentation IV
15 17 Gene Profiling & Microarray Handout #1
20 18 Disease Modifiers, SNP Handout #2
22 19 *Paper Presentation V
27 20 Protein Structure Reserve text, p 155-178
29 21 Proteomics (Dr. ZEIN) Reserve text, p 180-191
April
3 22 EXAM # 3 (25%)
5 23 The Mitochondrial Genome Lecture 5: 69-78
10 24 Genetic Basis of Cancer (DR. ZEIN) Lecture 6: 79-94
12 25 *Paper Presentation VI
17 26 Molecular Diagnostic/ Pharmocogenomics Handout #3
19 27 Human Genome & Development Lecture 7: 95-106
24 28 *Paper Presentation VII

26 29 FINAL EXAM (25%) 5:00 PM

* Graduate Students Only
**Final grades will be assigned using a curve based on the overall class performance