10/24/2014

tumor protein p73 [Rattus norvegicus] - Protein - NCBI

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tumor protein p73 [Rattus norvegicus]

NCBI Reference Sequence: NP_001102166.1
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NP_001102166
684 aa
linear ROD 09-FEB-2014
tumor protein p73 [Rattus norvegicus].
NP_001102166 XP_001077013 XP_342993
NP_001102166.1 GI:157822833
REFSEQ: accession NM_001108696.1
RefSeq.
Rattus norvegicus (Norway rat)
Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
1 (residues 1 to 684)
Carmona-Calero EM, Castaneyra-Ruiz L, Gonzalez-Toledo JM, de
Paz-Carmona H, Brage C, Castaneyra-Ruiz A, Rancel-Torres MN,
Gonzalez-Marrero I and Castaneyra-Perdomo A.
The expression of p73 in the organum vasculosum of the lamina
terminalis and choroid plexus of spontaneously hypertensive rats
Histol. Histopathol. 28 (7), 925-932 (2013)
23354845
GeneRIF: expression of p73 is weaker in the organum vasculosum of
the lamina terminalis and stronger in the choroid plexus of
hypertensive rats than in control rats
2 (residues 1 to 684)
Mouihate A and Al-Bader MD.
Glucocorticoid-induced fetal brain growth restriction is associated
with p73 gene activation
J. Neurosci. Res. 91 (1), 95-104 (2013)
23086675
GeneRIF: glucocorticoids negative impact on fetal brain development
likely is due to the modulation of the pro-survival dominant
negative p63 and p73 gene variants
3 (residues 1 to 684)
Klein A, Maldonado C, Vargas LM, Gonzalez M, Robledo F, Perez de
Arce K, Munoz FJ, Hetz C, Alvarez AR and Zanlungo S.
Oxidative stress activates the c-Abl/p73 proapoptotic pathway in
Niemann-Pick type C neurons
Neurobiol. Dis. 41 (1), 209-218 (2011)
20883783
GeneRIF: The main upstream stimulus activating the c-Abl/p73
pathway and neuronal apoptosis in Niemann-Pick type C neurons is
oxidative stress.
4 (residues 1 to 684)
Bui T, Sequeira J, Wen TC, Sola A, Higashi Y, Kondoh H and Genetta
T.
ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly
induced in response to cortical ischemia
PLoS ONE 4 (2), E4373 (2009)
19194497
GeneRIF: The pro-survival response of neurons, initiated through
the rapid induction of p63, is mediated ultimately by the
transcriptional repression of a pro-apoptotic isoform of p73 by
ZEB1.
5 (residues 1 to 684)
Sayan AE, Sayan BS, Gogvadze V, Dinsdale D, Nyman U, Hansen TM,
Zhivotovsky B, Cohen GM, Knight RA and Melino G.
P73 and caspase-cleaved p73 fragments localize to mitochondria and
augment TRAIL-induced apoptosis
Oncogene 27 (31), 4363-4372 (2008)
18362891
GeneRIF: P73 and caspase-cleaved p73 fragments localize to
mitochondria and augment TRAIL-induced apoptosis
6 (residues 1 to 684)
Hu JF, Ulaner GA, Oruganti H, Ivaturi RD, Balagura KA, Pham J, Vu
TH and Hoffman AR.
Allelic expression of the putative tumor suppressor gene p73 in
human fetal tissues and tumor specimens
Biochim. Biophys. Acta 1491 (1-3), 49-56 (2000)
10760569
7 (residues 1 to 684)
Schwartz DI, Lindor NM, Walsh-Vockley C, Roche PC, Mai M, Smith DI,
Liu W and Couch FJ.
p73 mutations are not detected in sporadic and hereditary breast
cancer
Breast Cancer Res. Treat. 58 (1), 25-29 (1999)

http://www.ncbi.nlm.nih.gov/protein/NP_001102166.1

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tumor protein p73 [Rattus norvegicus] - Protein - NCBI

10634515
8 (residues 1 to 684)
Chi SG, Chang SG, Lee SJ, Lee CH, Kim JI and Park JH.
Elevated and biallelic expression of p73 is associated
withprogression of human bladder cancer
Cancer Res. 59 (12), 2791-2793 (1999)
10383132
9 (residues 1 to 684)
Mai M, Qian C, Yokomizo A, Tindall DJ, Bostwick D, Polychronakos C,
Smith DI and Liu W.
Loss of imprinting and allele switching of p73 in renal cell
carcinoma
Oncogene 17 (13), 1739-1741 (1998)
9796703
10 (residues 1 to 684)
Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty
A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F and Caput D.
Monoallelically expressed gene related to p53 at 1p36, a region
frequently deleted in neuroblastoma and other human cancers
Cell 90 (4), 809-819 (1997)
9288759
PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from CH473968.1.
On or before Oct 4, 2007 this sequence version replaced
gi:109475899, gi:109477775.

Publication Note: This RefSeq record includes a subset of the

publications that are available for this gene. Please see the Gene
record to access additional publications.
FEATURES
Location/Qualifiers
source
1..684
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q36"
Protein
1..684
/product="tumor protein p73"
/note="transformation related protein 73"
/calculated_mol_wt=74448
Region
172..351
/region_name="P53"
/note="P53 DNA-binding domain; cd08367"
/db_xref="CDD:176262"
Site
order(239,242,303,307)
/site_type="other"
/note="zinc binding site [ion binding]"
/db_xref="CDD:176262"
Site
order(240..242,244)
/site_type="other"
/note="dimerization site [polypeptide binding]"
/db_xref="CDD:176262"
Site
order(304,306,313,338,340..342,345)
/site_type="DNA binding"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:176262"
Region
396..431
/region_name="P53_tetramer"
/note="P53 tetramerization motif; pfam07710"
/db_xref="CDD:254376"
Region
534..598
/region_name="SAM_tumor-p73"
/note="SAM domain of tumor-p73 proteins; cd09571"
/db_xref="CDD:188970"
Region
538..598
/region_name="SAM"
/note="Sterile alpha motif; smart00454"
/db_xref="CDD:197735"
CDS
1..684
/gene="Tp73"
/gene_synonym="P73; Trp73"
/coded_by="NM_001108696.1:4..2058"
/db_xref="GeneID:362675"
/db_xref="RGD:1307083"
ORIGIN
1 mssprqlday atalplqatg ppaplpkstd psraqvqprm sngvgemaqs sssssssstf
61 ehlwsslepd styfdlpqps qgnseatgse esnmdvfhlq gmtssvmaqf nllssamdqm
121 gsraapaspy tpehaasapt hspyaqpsst fdtmspapvi psntdypgph hfevtfqqss
181 taksatwtys pllkklycqi aktcpiqikv stppppgtai rampvykkae hvtdivkrcp
241 nhelgrdfne gqsapashli rvegnnlsqy vddpvtgrqs vvvpyeppqv gtefttilyn
301 fmcnsscvgg mnrrpilvii tletrdgqvl grrsfegric acpgrdrkad edhyreqqal
361 nesttkngaa skrafkqspp aipalgtnvk krrhgdedmf ymhvrgrenf eilmkvkesl
421 elmelvpqpl vdsyrqqqqq qllqrpshlq ppsygpvlsp mnkvhggvnk lpsvnqlvgq
481 ppphssaagp nlgsmgsgil nshshsmpan gemngghssq tmvsgshctp pppyhadpsl
541 vsfltglgcp nciecftsqg lqsiyhlqnl tiedlgalki pdqyrmtiwr glqdlkqshd
601 cgqqllrsss naatisiggs gelqrqrvme avhfrvrhti tipnrggagg vtgpdewadf
661 gfdlpdcksr kqpikeefte tesh
//

http://www.ncbi.nlm.nih.gov/protein/NP_001102166.1

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http://www.ncbi.nlm.nih.gov/protein/NP_001102166.1

tumor protein p73 [Rattus norvegicus] - Protein - NCBI

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