PSL301H Human Physiology II Course Syllabus 2013 Course Coordinator: Dr. Christine Wong E-mail: cjaye.wong@utoronto.

ca Office: Medical Sciences Building room MS3368 Meetings by appointment only Course Lecturers: Dr. Michelle French Dr. Anthony Gramolini Dr. Bob Richardson Dr. Christine Wong Arts & Science Course Overview Principles of respiratory, cardiovascular, gastrointestinal, and renal physiology for students enrolled in Life Science programs. Prerequisites: BIO130H1/BIO150Y1; CHM138H1, One full-course equivalent from: MAT100series and/or PHY100-series. Exclusion: PSL201Y Textbook: Official Reference Textbook: Silverthorn DU. Human Physiology: An Integrated Approach. 6th ed. Boston: Pearson, 2012. Earlier editions are acceptable but any page / figure references will be made to this one. Other Recommended References: Sherwood & Kell: Human Physiology, 1st Cnd ed., Nelson; Rhoades & Tanner: Medical Physiology, Lippincott; and Ganong: Review of Medical Physiology, Lange. Lectures: 3hrs/week - Monday, Wednesday, and Friday, 2 3 pm, Convocation Hall Tutorials: 4hrs/term - Monday, Wednesday, or Friday, 1-2 pm, 3-4 pm, or 4-5 pm, rooms TBA Tutorial Dates: Jan 21, 23, or 25 Blood and immunity Feb 11, 13, or 15 Cardiovascular Feb 25, 27, or Mar 1 Respiratory Mar 22, 25, or 27 Renal Marking Scheme: Mid-Term Test 32% (covers all material from Jan 7 Feb 15, inclusive) Final Exam 68% (covers all course material) Total 100%

Course Schedule BLOOD & IMMUNE SYSTEM (5 lectures) - Dr. French Date Topic January 7 Blood: constituents and functions of plasma 9 Erythrocytes 11 Leukocytes I 14 Leukocytes II 16 Platelets and blood coagulation CARDIOVASCULAR SYSTEM (9 lectures) - Dr. Gramolini Date Topic January 18 The heart: cardiac muscle; excitation; conduction 21 Cardiac action potential 23 From action potential to aortic flow 25 Cardiac cycle 28 Regulation of heart action 30 Venous return February 1 Blood vessels: structure and hemodynamics 4 Regulation of peripheral resistance 6 The microcirculation RESPIRATORY SYSTEM (6 lectures) - Dr. French Date Topic February 8 Structure of respiratory tract, mechanics of respiration 11 Divisions of lung air, ventilation rates 13 Respiratory gas exchange and transport 15 Control: centers, receptors, pathways < 18-22 > READING WEEK - NO LECTURES 25 Respiratory regulation of acid-base balance Exercise: effects on respiratory and cardiovascular systems 27 ELECTROLYTE & WATER BALANCE (8 lectures) - Dr. Richardson Date Topic March 1 Total body water, body fluid compartments 4 Mid-Term Test 6 Fluid exchange: intracellular and extracellular Renal regulation: the nephron, glomerular filtration 8 < 10 > Last day to cancel S section code courses 11 Principles of tubular transport 13 Regulation of sodium balance 15 Regulation of potassium balance 18 Regulation of water balance 20 Renal regulation of acid-base balance

DIGESTIVE SYSTEM (6 lectures) - Dr. Wong Date Topic March 22 Overview: basic structure and function 25 Regulation of G.I. tract activity 27 G.I. tract fluids, composition, function < 29 > UNIVERSITY CLOSED Good Friday April 1 Regulation of digestive processes and reflexes Digestion of proteins and fats: pancreas, pancreatic enzymes, 3
liver, bile

5 EXAM PERIOD Date TBA

Digestion of carbohydrates. Role of fiber, large intestine

Topic Final Exam

Tutorials The tutorials are designed to be both relevant and entertaining, thereby helping you understand the lecture material. There are 4 tutorials scheduled for the course, distributed irregularly (see the Tutorial section of the course website). How to get the most out of the tutorials Before the tutorial Do the suggested background reading/lecture review; Read the tutorial case or description; and Write down an answer for all of the questions. In the tutorial Participate fully in your groups discussion; After the tutorial Review the lecture concepts that you had trouble with. During the entire week following tutorial weeks, a 10-minute on-line quiz will be available: 5 multiple questions based on the previous tutorial material. Always do the quiz, both to assess your progress in learning the material, and to practice doing multiple choice questions. If it takes you longer than 10 minutes to complete the quiz, then you know that you need to improve your performance. Note: Data from previous PSL301H classes shows that students who attended tutorials and complete on-quizzes had significantly higher mean exam marks than those who did not attend any tutorial or who attended only one tutorial. Evaluation The format of the term test is similar to that of the final exam and both are based primarily on the lecture material, but enrichment of your knowledge from recommended texts and the tutorials is advised.
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Mid-Term Test. There will be one mid-term test, of 50 minute duration and containing about 26 questions. The mid-term test is worth 32% of your final mark. All questions are multiple choice, each with only ONE appropriate answer. The score for each question is ONE OR ZERO. The answers will be posted on the course website after the make-up test is written (usually the following week); test results are posted on the website under My Grades a few days after the test. Supplementary (Make-up) Term Test. Students who miss a term test for genuine, documented medical reasons may write the make-up test. An official U of T medical certificate (http://www.economics.utoronto.ca/munro5/UofTMedicalCert.pdf) must be submitted to the course coordinator within one week of the date of the missed test. The make-up test will be scheduled approximately 10 days after the regularly scheduled test. Those students who miss both the test and the make-up will receive a mark of 0 for that portion of their term mark. April (Final) Examination. The date will be scheduled by the Faculty of Arts and Science. The exam covers all of the course material, lasts 2 hours, contains 56-60 multiple choice questions, and is worth 68% of your final mark.

Course Website The schedule of lectures and important announcements will be posted on the course website. For all sections of the course, extensive lecture material in the form of .pdf slides will be available for perusal. Short quizzes will also be posted regularly (after each tutorial). Students are urged to do the quizzes; they provide excellent practice for writing tests. A course Discussion Board is also provided for communication among members of the class. Queries may be posted to lecturers regarding lecture material, but it is preferable that other members of the class answer the questions. This creates the best learning situation for all concerned. The lecturer will respond only when the answers are off-base. The bulletin board is not a place to denigrate individuals or badmouth lecturers; if you have a personal complaint, send an e-mail to the course coordinator. Please maintain appropriate decorum on the Discussion Board. The following is a partial list of the kind of content that is offensive and prohibited on the site. It includes content that: promotes racism, bigotry, hatred or physical harm of any kind against any group or individual; harasses or advocates harassment of another person; involves the transmission of "junk mail", "chain letters", or unsolicited mass mailing or "spamming" promotes information that you know is false, misleading, or promotes illegal activities or conduct, is abusive, threatening, obscene, defamatory or libellous; is or promotes an illegal or unauthorized copy of another person's work, such as providing pirated computer programs or links to them, provides information to circumvent manufactureinstalled copy protect devices;

 contains restricted or password only access pages, or hidden pages or images (those not linked to or from another accessible page) displays pornographic material of any kind; provides instructional information about illegal activities such as making or buying illegal weapons; violating someone's privacy; providing or creating computer viruses; solicits passwords, personal identifying information for commercial or unlawful purposes from other users. To gain access to the Physiology 301H course notes, tutorial quizzes, discussion board and announcements, go to the Blackboard site: http://portal.utoronto.ca/ and login using your UTORid code.