Arjuna supplement health benefit and side effects, dosage and research studies by Ray Sahelian, M.D.

500 mg tablets Ancient medical scientists have mentioned the properties of arjuna herb. Indian medical knowledge known as Ayurveda goes back millennia. The Vedas and Puranas refer various materials of medical importance including herbs, plants and trees. Modern research has discovered that arjuna has antioxidant properties and may be clinically helpful in cardiovascular health. Substances found in arjuna herb Triterpene glycosides, arjunetin, arjunetoside, arjunaphthanoloside, together with oleanolic and arjunic acids, terminic acid, a cardenolide, and strong antioxidants (flavones, tannins, oligomeric proanthocyanidins), have been isolated from the root bark of terminalia arjuna. buy Arjuna, 550 mg dosage, 120 Tablets - Planetary Formulas Supplement Facts Serving Size 1 Tablet Amount Per Serving Calcium - 30 mg Terminalia arjuna Bark - 500 mg Terminalia arjuna Bark extract - 50 mg (standardized 10:1 extract, meaning it is 10 times more concentrated than the plain bark powder)
Suggested use: Take one Arjuna tablet once a day or as recommended by your health care provider.

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Benefit for health Angina pectoris Arjuna has been tested in patients with angina. The herb dilates blood vessels, even in cigarette smokers.

Efficacy of Terminalia arjuna in chronic stable angina: a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbide mononitrate. Indian Heart J. 2002. Fifty-eight males with chronic stable angina (NYHA class II-III) with evidence of provocable ischemia on treadmill exercise test received Terminalia arjuna (500 mg 8 hourly), isosorbide

mononitrate (40 mg/daily) or a matching placebo for one week each. Arjuna therapy was associated with significant decrease in the frequency of angina and need for isosorbide dinitrate. The total duration of exercise increased, maximal ST depression during the longest equivalent stages of submaximal exercise decreased, time to recovery decreased, and higher double products were achieved. Terminalia arjuna bark extract, 500 mg 8 hourly, given to patients with stable angina with provocable ischemia on treadmill exercise, led to improvement in clinical and treadmill exercise parameters as compared to placebo therapy. Antioxidant benefit Antioxidant and hypocholesterolaemic effects of Terminalia arjuna tree-bark powder: a randomised placebo-controlled trial. J Assoc Physicians India. 2001. We found this tree bark powder has significant antioxidant action that is comparable to vitamin E. In addition, it also has a significant cholesterol lowering effect. Antiplatelet actions
Substances in this plant have anti-platelet activity, meaning they can thin the blood.

Inhibitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets. 2009; Malik N. Department of Experimental Medicine & Biotechnology, Chandigarh, India. Twenty patients of angiographically proven coronary artery disease were included in Group I and 20 age and sex-matched controls were included in Group II. The bark extract is able to significantly inhibit platelet aggregation both in patient and control groups. Our data clearly demonstrates that the bark extract of terminalia arjuna decreases platelet activation and may possess anti-thrombotic properties. Cancer
Substance in the plant protect against certain forms of cancer.

Effects of Terminalia arjuna bark extract on apoptosis of human hepatoma cell line HepG2. World J Gastroenterol 2006. To investigate the effects of Terminalia arjuna extract on human hepatoma cell line (HepG2) and its possible role in induction of apoptosis. T. arjuna induced cytotoxicity in HepG2 cells in vitro. Apoptosis of HepG2 cells may be due to the DNA damage and expression of apoptotic proteins. Depletion of GSH may be involved in the induction of apoptosis of HepG2 cells. Casuarinin from the Bark of Terminalia arjuna Induces Apoptosis and Cell Cycle Arrest in Human Breast Adenocarcinoma MCF-7 Cells. Planta Med. 2005. Casuarinin, a hydrolyzable tannin isolated from the bark of Terminalia arjuna, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. The results showed that casuarinininhibited the proliferation of MCF-7 by blocking cell cycle progression in the G0/G1 phase and inducing apoptosis.

Cholesterol metabolism
Compounds in Arjuna may help reduce cholesterol levels.

DNA protection
Arjuna has compounds that protect against DNA damage from toxins.

Effect of Terminalia arjuna extract on adriamycin-induced DNA damage. Phytother Res. 2008; Reddy TK, Seshadri P. Division of Cancer Biology, Sugen Life Sciences, Tirupati, AP, India. The effect of a bark extract of Terminalia arjuna was studied on the alteration of adriamycin (ADR)-induced micronuclei formation in cultured human peripheral blood lymphocytes. Our results demonstrate that it protects DNA against ADR-induced damage. Hardening of the arteries Terminalia arjuna reverses impaired endothelial function in chronic smokers. Indian Heart J. 2004. Smoking, largely through increased oxidative stress, causes endothelial dysfunction which is an early key event in atherosclerosis. The present study was aimed to determine whether Terminalia arjuna would improve endothelial dysfunction in smokers. Smokers have impaired endothelium-dependent but normal endothelium-independent vasodilation as determined by brachial artery reactivity studies. Arjuna therapy for two weeks leads to significant regression of this endothelial abnormality amongst smokers. Heart attack, myocardial infarction
Arjunolic acid, a new triterpene and a potent extract from the bark of Terminalia arjuna, has been shown to provide significant cardiac protection in myocardial necrosis in rats. Arjunolic acid treatment prevents the decrease in the levels of powerful antioxidants such as superoxide dismutase, catalase, glutathione, alpha-tocopherol, and ascorbic acid.

Terminalia arjuna protects rabbit heart against ischemic-reperfusion injury: role of antioxidant enzymes and heat shock protein. J Ethnopharmacol. 2005. The bark of Terminalia arjuna is widely recommended for the treatment of ischemic heart disease (IHD) in Indian system of medicine. Oral administration for 12 weeks in rabbits caused augmentation of myocardial antioxidants; superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) along with induction of heat shock protein72. In vivo ischemicreperfusion injury induced oxidative stress, tissue injury of heart and haemodynamic effects were prevented in the Terminalia arjuna treated rabbit hearts. Cardioprotective effect of the alcoholic extract of Terminalia arjuna bark in an in vivo model of myocardial ischemic reperfusion injury. Life Sci. 2003. The present study was designed to investigate the effects of chronic administration of the alcoholic extract of terminalia arjuna bark on isoproterenol induced myocardial injury given orally to Wistar albino rats 6 days/week for 4 weeks. At the end of this period, all the animals, except the normal untreated rats that served as the control group, were administered isoproterenol for two consecutive days to induce in vivo myocardial injury. A significant rise in myocardial thiobarbituric acid reactive substances (TBARS) and loss of

reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (suggestive of increased oxidative stress) occurred in the hearts subjected to in vivo myocardial ischemic reperfusion injury. In vivo ischemic reperfusion injury of the arjuna treated rats there was a significant decrease in TBARS in all the groups. The present study demonstrates that arjuna augments endogenous antioxidant compounds of the rat heart and also prevents the myocardium from isoproterenol induced myocardial ischemic reperfusion injury. Hypertension, lowering of blood pressure Possible mechanisms of hypotension produced 70% alcoholic extract of Terminalia arjuna in anaesthetized dogs. BMC Complement Altern Med. 2003. Intravenous administration produced dose-dependent hypotension in anaesthetized dogs. My husband and I have used arjuna supplements for the past few months and we both believe it has lowered our blood pressure. I was diagnosed with hypertension many years ago and since then have been prescribed various allopathic drugs, most recently Atenolol. I reduced the dosage of Atenolol and replaced it gradually with arjuna which we purchased online from you. I have been taking arjuna exclusively for a few week. My blood pressure seems to have been as well controlled by arjuna as it was previously by allopathic drugs and from this aspect, I see no reason why I should not continue taking it exclusively. However, I am concerned about the seeming lack of any documentation regarding its long term effects. Information on such effects is readily available in respect of allopathic anti-hypertensives. If arjuna terminalia has such a long history of use in such conditions, surely there must be some data on the effects of long term use - even if the conclusion is that there is no traceable effect. Even though Arjuna has a long history of use, this was probably recorded in India and has not make it to the Western medical research information base. As soon as we get any info on this topic we will mention it in our newsletter. Mitral regurgitation Role of Terminalia arjuna in ischaemic mitral regurgitation. Int J Cardiol. 2005. Dwivedi S, Aggarwal A. We planned a study to evaluate the role of T. arjuna in ischemic mitral regurgitation (IMR) following acute myocardial infarction (AMI). 40 patients with fresh AMI showing IMR were randomly divided into 2 groups of 20 each. They were given placebo or 500 mg of T. arjuna in addition to anti-ischemic treatment. After 1 and 3 months of follow up, patients receiving adjuvant T. arjuna showed significant decrease in IMR and considerable reduction in anginal frequency. Stroke I had 2 strokes, can not take Plavix, I have started on natural remedies. I am no longer on Lipitor, Lopressor, or Lotrel. My doctor knows that I am taking natural remedies, and he checks me out, and feel I am o.k. Will Arjuna work with natural products that I am taking to lower my blood pressure and reduce the risk for stroke? I have not seen studies in relation to stroke incidence reduction, but it is possible.

Side effects, adverse reactions No significant side effects have been published in medical journals as of 2012. There may be a slight feeling of warmth or increased body temperature after taking a pill. Other brands I have been ordering my Arjuna from Himalaya for quite some time. I just happened to look at the bottle today and noticed, among its ingredients colloidal silicon dioxide. Im no scientist but that doesnt sound like a good thing to be taking. Is this a natural ingredient? I was wondering if your Arjuna has that ingredient in it? If it doesnt, maybe I should be buying my this herbal product from your company. We do not think colloidal silicon dioxide is harmful, the amounts in the capsules are often very very small. The product we carry has Other Ingredients: microcrystalline cellulose, dibasic calcium phosphate, stearic acid, hydroxypropyl cellulose, colloidal silicon dioxide and modified cellulose gum. These are also safe. You may wish to keep using the product you have or try another.

Phyllanthus Niruri
Ask for price Botanical Name : Phyllanthus Niruri Sanskrit Name: Bhumi Amla English Name : Niruri Family : Euphorbiaceae Part used: Whole Plant Description of Phyllanthus Niruri: It is a small, erect, annual herb that grows 3040 cm in height. It is indigenous to the rainforests of the Amazon and other tropical areas throughout the world, including the Bahamas, southern India, and China. P. niruri is quite prevalent in the Amazon and other wet rainforests, growing and spreading freely (much like a weed). P. amarus and P. sellowianus are closely related to P. niruri in appearance, phytochemical structure, and history of use, but typically are found in the drier tropical climates of India, Brazil, and even Florida and Texas. Uses : Phyllanthus blocks DNA polymerase, the enzyme needed for the hepatitis B virus to reproduce. It also prevent from jaundice,diabetes, dyspepsia, ulcers, sores, swellings, ophthalmia and chronic dysentery. Whole plant is useful for the treatment of some forms of gonorrhea, menorrhagia, dropsy, menorrhagia and other genito- urinary affections of a similar type. A poultice of the leaves mixed with salt cures itch and other skin affections. It is bitter, astringent, cold, anti-inflammatory, hepatoprotective and useful in liver disorders, cough, asthma, jaundice, spleen disorders. Phyllanthus may help decrease the amount of hepatitis B virus found in the blood stream. Principal Constituents: Phyllanthin (bitter constituent) and hypophyllanthin (non-bitter compound) are isolated from the leaves. From the aerial parts phyllanthine (4-methoxy-securinine) and 4- methoxy-norsecurinine are identified 1. From the roots glycoflavones were isolated. Lintetralin was also isolated from the plant 3. Amariin, a novel hydrolysable tannin together with geraniin, corilagin, 1,6-digalloyl-glucopyranoside as well as a rutin and quercetin- 3-O-lucopyranoside have been isolated from the polar fraction. An unusual hydrolysable tannin, phyllanthusiin D has also been isolated from the biologically active polar fraction. Pharmacology: The alcoholic extract of the whole plant has anti-cancer activity against Freund virus Leukaemia (solid) in the mouse and antispasmodic activity on isolated guinea pig ileum. Aqueous extract of whole plant has hypoglycaemic action in normal and alloxan-diabetic rabbits and leaves to be higher than that of tolbutamide. Clinical Studies It is effective in treatment of infective hepatitis without any adverse effect. It shown to be effective with other Siddha drugs in the treatment of jaundice due to infective hepatitis . .
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