LEF April 2013

The ULTIMATE Source For New Health And Medical Findings From Around The World April 2013
WHY DOCTORS ARENT CURING HEART DISEASE

FRAN DRESCHERS
Mission to Defeat Cancer
Beans and Barley
Slow Glucose
Absorption
A Better Form
of Astaxanthin
Preempt Cancer with
Cruciferous Vegetables
Rejuvenate Aged
Neck Tissues
OMEGA-3s
UNDER ATTACK!
Scientic Rebuttal to
Flawed AMA Report
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Supports Cellular Energy Metabolism!
A common complaint among older adults is loss of physical and mental energy.
As people age, their cells ability to produce energy is diminished. Many scientists believe
that cellular energy defcit is a critical factor in the onset of many problems.
Unlike other rhodiola supplements on the market
today, Rhodiola Extract uses only the authentic Rhodiola
rosea species and is standardized to contain 3% rosavins
and not less than 1% salidrosidesmatching the concen-
trations of active adaptogens used in clinical trials.
Rhodiola Extract is an extremely
low-cost supplement. The retail price of
a bottle of 60 vegetarian capsules (a
two- month supply) of Rhodiola Extract
is just $11.75. If a member orders four
bottles, the price is reduced to only
$7.94 per bottle!
Caution: Individuals with manic or bipolar
disorder should not use Rhodiola. Take early in the
day if Rhodiola Extract interferes with your sleep.
The Russian herb rhodiola (Rhodiola rosea) has
demonstrated a remarkable ability to support cellular
energy metabolism.* Rhodiola promotes higher levels
of ATP (adenosine triphosphate) and CP (creatine
phosphate) in the cellular power plants known as the
mitochondria, thus providing more of the energy
molecules need to power many daily activities.
1
In a human trial, rhodiola aided exercise endur-
ance after just a single dose.
2
In another double-blind,
crossover human trial, rhodiola increased several
measures of mental performance, including associa-
tive thinking, short-term memory, calculation,
concentration, and speed of audiovisual perception.
Statistically signifcant improvements were reported
after just two weeks of supplementation.
3
Life Extension has formulated a Rhodiola Extract
that provides 250 mg of Rhodiola rosea extract in each
capsule.
To order Rhodiola Extract,
call 1-800-544-4440 or
visit www.LifeExtension.com
References
1. Proceedings Institute of Cytology of Russian Academy of Science. 1971;89-92.
2. Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307.
3. Phytomedicine. 2000 Oct;7(5):365-71.
Item # 00889 I 00889

APRIL 2013 | LIFE EXTENSION | 1
24 ENHANCED ASTAXANTHIN FOR BETTER ABSORPTION
Over the past decade, researchers have recognized that astaxan-
thins unique molecular structure traps more free radicals compared
to most other nutrients. Its full benets, however, have been limited
due to its relatively poor absorption ability. By combining carot-
enoids like astaxanthin with phospholipids, their bio-availability
increases by nearly 12-fold for more potent systemic protection.
36 FOODS THAT SAFELY REDUCE BLOOD GLUCOSE
Maintaining optimal blood sugar levels is a powerful predictor of
longevity. In addition to the proven strategies used by Life Extension

members, certain foodsnotably barley and black beanscan
lower blood glucose levels. Incorporating these foods into your diet
can help prevent glycemic-related disorders such as diabetes, heart
disease, cancer, and obesity.
54 SHIELD YOURSELF FROM ENVIRONMENTAL CANCER RISKS
On a daily basis we are surrounded by environmental toxins found
in drinking water, pesticides, and plastics that can trigger the onset
of cancer. Decades of research have shown that cruciferous
vegetables help your body neutralize these toxins and slash your
risk of cancer by up to 54%.
68 MISCONCEPTIONS ABOUT ATHEROSCLEROSIS
Cardiovascular disease causes one of every three deaths in the
United States. Most heart attacks and strokes are caused by athero-
sclerosis. Because mainstream doctors only treat one or two of the
multifactorial causes of this disease, heart attacks remain the leading
cause of death. Reduce your risk by taking steps to manage and
eliminate all 17 proven causes of arterial disease.
78 HOW ATHEROSCLEROSIS DEVELOPS IN AGING HUMANS
At least one of every two Americans over the age of 65 has athero-
sclerosis. By understanding the development of this disease and
controlling the risk factors, you can potentially reverse dangerous
occlusions of vital arteries.
86 REJUVENATE YOUR AGING NECK
Most skin care regimens target the face in order to reduce the signs
of aging. However, the thin skin on your neck quickly reveals the pas-
sage of time through accelerated sagging and wrinkles. Formulators
have combined specic cell-communicating compounds that reacti-
vate aging skin cells to repair and tighten the necks delicate skin.
TABLE OF CONTENTS
17 IN THE NEWS
Grape seed extract protects against
colorectal cancer; magnesium intake low-
ers fasting glucose and insulin; anthocya-
nins reduce heart attack risk up to 32%;
curcumin lowers rheumatoid arthritis pain
better than common medication; partici-
pants sought for study examining calorie
restrictions effect on telomere length;
and more.
95 AUTHOR INTERVIEW
In his new book, Dr. Neal Barnard reveals
how new imag ing techniques allow
scientists to better understand the aging
brain. Here, he reveals his groundbreak-
ing 3-step plan that incorporates spe-
cic foods, nutrients, and environmental
factors to help you prevent Alzheimers
disease and dementia.
ON THE COVER
7 REBUTTAL TO ATTACK
AGAINST FISH OIL
Despite improvements in
prevention and treatment,
heart disease kills 600,000
Americans each year, and
stroke nearly 130,000. In the
face of this epidemic carnage,
the American Medical
Association published a report
questioning the value of sh
oil in cardiovascular disease
patients. This rebuttal
exposes the many aws in the
American Medical Association
report, the inaccurate portrayal
of it by the media, and the
inability of most doctors to
understand that successful
treatment of atherosclerotic
disease requires more
than one intervention.
46 FRAN DRESCHERS
CRUSADE TO END CANCER
After eight doctors and as
many misdiagnosis, TV
star Fran Drescher nally
discovered that she had
gynecological cancer. Based
on this medical ordeal,
Drescher founded the Cancer
Schmancer movement, which
focuses on early diagnosis,
prevention through healthy
choices, and avoiding
cancer-causing environmental
toxins. Her mission is to have all
Americans either prevent cancer
or be diagnosed no later
than stage one.

LifeExtension
VOLUME NINETEEN / NUMBER FOUR Q April 2013

R E P O RT S

D E PART ME NT S
2 | LIFE EXTENSION | APRIL 2013
LifeExtension
VOLUME NINETEEN / NUMBER FOUR Q APRIL 2013

LIFE EXTENSION (ISSN 1524-198X) Vol. 19, No.4 2013 is published monthly except semi-monthly in April by LE Publications, Inc. at 3600 West Commercial Blvd., Fort Lauderdale, FL
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EDITORIAL
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SCIENTIFIC ADVISORY BOARD
rn Adalsteinsson, PhD Pussell L. Blaylock, MD 1ohn Boik, PhD
Eric P. Braverman, MD Aubrey de Grey, PhD Frank Eichorn, MD
Deborah F. Harding, MD Steven B. Harris, MD Stanley W. 1acob, MD
Pichard Kratz, MD, DSci Peter H. Langsjoen, MD, FACC Palph W. Moss, PhD
Michael D. Ozner, MD, FACC Pobert Pastore, PhD, CNS
1onathan Treasure, AHG, MNlMH 1onathan v. Wright, MD
CONTRIBUTORS
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To order Optimized Cran-Max
with UTIRose,
call 1-800-544-4440 or visit www.LifeExtension.com
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The anatomy of the female
urinary tract diers greatly from
men, resulting in the need for
additional nutritional support
for women.
A wealth of published studies indicates that
cranberry polyphenols may help to support a
healthy urinary tract.
1-5
Of particular importance is the avonoid content
of the cranberry, including anthocyanins and proantho-
cyanidins. These natural compounds exert powerful
antioxidant eects that can reduce oxidative stress.
Recent clinical data suggest that the proantho-
cyanidins found only in cranberries also possess unique
molecular features that specically promote urinary
system health.
6-8
A Synergistic Compound Available
Only in EuropeUntil Now
In a signicant advance, Life Extension
has
identied a unique compound available overseas
but little-known in the United States that provides a
synergistic complement to the whole cranberrys
phytonutrient prole.
UTIRose

is derived from Hibiscus sabdaria, a
species native to Europe, Asia, and Africa. Scientic
analysis has shown that this species ower and calyx
(the green oral envelope surrounding the blossom)
are rich in active polyphenols, including avonoids,
sambubiosides, and anthocyanins.
Optimized Cran-Max
with UTIRose

Featuring a Novel High-Concentration
Hibiscus Polyphenol Blend
NEXT-GENERATION FORMULA
Life Extension
uses a unique, patented

process in the manufacture of Optimized Cran-Max

with UTIRose. Each daily serving supplies the
complete phenolic prole of the whole cranberry plus
hibiscus polyphenols in a standardized, highly absorb-
able, concentrated form. Two capsules of Optimized
Cran-Max
with UTIRose contain:

UTIRose (Hibiscus sabdaria) 200 mg
extract (ower, calyx)
Cran-Max
Cranberry infused 500 mg

whole fruit extract
The suggested daily amount of
Cran-Max
in this formula alone

(500 mg) was demonstrated to provide
the anthocyanin equivalent of seven
8 oz glasses of Ocean Spray
Cranberry
Juice Cocktail.
9
The price for one bottle of Optimized
Cran-Max
with UTIRose containing

60 vegetarian capsules is $18. If a member
buys four bottles, the price is reduced to
$12 per bottle.
References
1. Cochrane Database Syst Rev. 2004;(2):CD001321
2. Mol Nutr Food Res. 2007 Jun;51(6):732-7.
3. Evid Based Med. 2008 Aug;13(4):105.
4. BMJ. 2001;322:1-5.
5. Phytomedicine. 2007;14(4):237-41.
6. J Med Food. 2009 Apr;12(2):259-70.
7. Crit Rev Food Sci Nutr. 2002;42(3 Suppl):273-8.
8. Wien Med Wochenschr. 2007;157(13-14):325-30.
9. Cran-Max
versus Ocean Spray Cranberry Juice cocktail

bioactive comparison. Independent laboratory analysis.
Tucson, AZ: Atlas Bioscience, Inc.; 2006.
Cran-Max
registered trademark of BDM Technologies, LLC. UTIrose is a trademark of Burgundy Botanical Extract. Bio-Shield
is a registered trademark of Bio-Nutra Technologies, LLC.

Item # 01424
MEDI CAL ADVISORY BOARD
Gustavo Tovar Baez, MD, operates the
Life Extension Clinic in Caracas, Venezuela.
He is the rst physician in Caracas to
specialize in anti-aging medicine.
Ricardo Bernales, MD, is a board-certied
pediatrician and general practitioner in
Chicago, IL, focusing on allergies, bronchial asthma,
and immunodeciency.
Thomas F. Crais, MD, FACS, a board-certied
plastic surgeon, was medical director of the
microsurgical research and training lab at
Southern Baptist Hospital in New Orleans, LA, and
currently practices in Sun Valley, ID.
William Davis, MD, is a preventive cardiologist and
author of Wheat Belly: Lose the Wheat, Lose the
Weight and Find Your Path Back to Health. He is
also medical director of the online heart disease
prevention and reversal program, Track Your Plaque
(www.trackyourplaque.com).
Martin Dayton, MD, DO, practices at the Sunny
Isles Medical Center in North Miami Beach, FL. His
focus is on nutrition, aging, chelation
therapy, holistic medicine, and oxidative medicine.
John DeLuca, MD, DC, is a 2005 graduate of St.
Georges University School of Medicine. He com-
pleted his Internal Medicine residency at Monmouth
Medical Center in Long Branch, New Jersey, in
2008 and is board certied by the American Board
of Internal Medicine. Dr. DeLuca is a Diplomate of
the American Academy of Anti-Aging Medicine and
has obtained certications in hyperbaric medicine,
pain management, nutrition, strength and condition-
ing, and manipulation under anesthesia.
Sergey A. Dzugan, MD, PhD, was formerly chief
of cardiovascular surgery at the Donetsk Regional
Medical Center in Donetsk, Ukraine. Dr. Dzugans
current primary interests are anti-aging and biologi-
cal therapy for cancer, cholesterol, and hormonal
disorders.
Patrick M. Fratellone, MD, RH, is the founder and
executive medical director of Fratellone Associates.
He completed his Internal Medicine and Cardiology
Fellowship at Lenox Hill Hospital in 1994, before
becoming the medical director for the Atkins Cen-
ter for Complementary Medicine.
Carmen Fusco, MS, RN, CNS, is a research sci-
entist and clinical nutritionist in New York City who
has lectured and written numerous articles on the
biochemical approach to the prevention of aging
and degenerative diseases.
Norman R. Gay, MD, is proprietor of the Bahamas
Anti-Aging Medical Institute in Nassau, Bahamas.
A former member of the Bahamian Parliament, he
served as Minister of Health and Minister of Youth
and Sports.
Mitchell J. Ghen, DO, PhD, holds a doctorate
in holistic health and anti-aging and serves
on the faculty of medicine at the Benemerita
Universidad Autonoma De Puebla, Mexico,
as a professor of cellular hemapoetic studies.
Gary Goldfaden, MD, is a clinical dermatologist
and a lifetime member of the American Academy of
Dermatology. He is the founder of Academy
Dermatology of Hollywood, FL, and COSMESIS
Skin Care.
Miguelangelo Gonzalez, MD, is a certied
plastic and reconstructive surgeon at the Miguelan-
gelo Plastic Surgery Clinic, Cabo San Lucas.
Garry F. Gordon, MD, DO, is a Payson, AZ-based
researcher of alternative approaches to medical
problems that are unresponsive to traditional thera-
pies. He is president of the International
College of Advanced Longevity Medicine.
Richard Heifetz, MD, is a board-certied
anesthesiologist in Santa Rosa, CA, specializing
in the delivery of anesthesia for ofce-based
plastic/cosmetic surgery, chelation therapy, and
pain management.
Roberto Marasi, MD, is a psychiatrist in Brescia
and in Piacenza, Italy. He is involved in anti-aging
strategies and weight management.
Maurice D. Marholin, DDC, DO, is a licensed os-
teopathic physician and chiropractor. He completed
a NIH Fellowship in nutrition at UAB. Board certi-
ed in family medicine with a CNS
in nutrition, he is currently the medical
director at Leon County Jail. He is responsible
for 1,1001,200 inmates medical needs.
Prof. Francesco Marotta, MD, PhD, gastroenterolo-
gist and nutrigenomics expert with extensive inter-
national university experience. Consulting Professor,
WHO-afliated Center for Biotech & Traditional
Medicine, University of Milano, Italy. Hon. Res. Pro-
fessor, Human Nutrition Dept, TWU, USA. Author of
over 130 papers and 400 congress lectures.
Philip Lee Miller, MD, is founder and medical
director of the Los Gatos Longevity Institute in
Los Gatos, CA.
Michele G. Morrow, DO, FAAFP, is a
board-certied family physician who merges
mainstream and alternative medicine using
functional medicine concepts, nutrition, and natural
approaches.
Herbert Pardell, DO, FAAIM, practices internal
medicine at the Emerald Hills Medical Center in
Hollywood, FL. He is a medical director of the
Life Extension Foundation.
Lambert Titus K. Parker, MD, practices internal
medicine at the Integrative Longevity Institute of
Virginia in Virginia Beach, VA.
Ross Pelton, RPh, PhD, CCN, is director of
nutrition and anti-aging research for Intramedicine,
Inc.
Patrick Quillin, PhD, RD, CNS, is a clinical
nutritionist in Carlsbad, CA, and formerly served as
vice president of nutrition for Cancer
Treatment Centers of America, where he was a
consultant to the National Institutes of Health.
Allan Rashford, MD, graduated from the University
of Iowa Medical School. Upon completing medical
training, he became chief of medicine at St. Francis
Hospital in South Carolina, and he was later named
president of the Charleston Medical Society.
Marc R. Rose, MD, practices ophthalmology in
Los Angeles, CA, and is president of the Rose
Eye Medical Group. He is on the staffs of Pacic
Alliance Medical Center, Los Angeles, and other
area hospitals.
Michael R. Rose, MD, a board-certied
ophthalmologist with the Rose Eye Medical
Group in Los Angeles, CA, is on the staffs of
the University of Southern California and UCLA.
Ron Rothenberg, MD, is a full clinical professor
at the University of California San Diego School of
Medicine and founder of California
HealthSpan Institute in San Diego, CA.
Roman Rozencwaig, MD, is a pioneer in
research on melatonin and aging. He practices
in Montreal, Canada, as research associate at
Montreal General Hospital, Department of
Medicine, McGill University.
Carol Ann Ryser, MD, FAAP, is medical director of
Health Centers of America in Kansas City, MO, and
focuses on pediatrics and mental health.
Michael D. Seidman, MD, is the regional coordina-
tor of otolaryngology-head and neck surgery for the
Bloomeld satellite of Henry Ford Health System
(HFHS), Detroit, MI, co-director of the Tinnitus
Center, and co-chair of the Complementary/Alterna-
tive Medicine Initiative for HFHS.
Ronald L. Shuler, BS, DDS, CCN, LN, is involved
in immunoncology for the prevention and treatment
of cancer, human growth hormone secretagogues,
and osteoporosis. Board certied in Anti-Aging
medicine.
Herbert R. Slavin, MD, is medical director of the
Institute of Advanced Medicine in Lauderhill, FL,
specializing in anti-aging medicine, disease
prevention, chelation therapy, and natural
hormone replacement therapy.
Stephen L. Smith, MD, Richland, WA, focuses
on treating allergies and is a member of the Ameri-
can Society for Lasers in Medicine and Surgery.
Stephen Strum, MD, is a medical oncologist
who has specialized in prostate cancer treatment
since 1983. He is co-founder and past medical
director of the Prostate Cancer Research Institute.
Currently, he directs a practice for prostate cancer
patients in Ashland, OR.
Javier Torres, MD, is a member of the
American Academy of Physical Medicine and
Rehabilitation and is on the medical staffs of
Sunrise Hospital, Desert Springs Hospital,
Valley Hospital, and Mountain View Hospital,
all in Las Vegas, NV.
Paul Wand, MD, Fort Lauderdale, FL, is a clinical
neurologist with special expertise in treating and
reversing diabetic peripheral neuropathy and brain
injuries from various causes.
Charles E. Williamson, MD, Boca Raton, FL,
focuses on anti-aging, longevity, and pain
management.
Jonathan V. Wright, MD, is medical director of the
Tahoma Clinic in Renton, WA. He received his MD
from the University of Michigan and has taught
natural biochemical medical treatments since
1983. Dr. Wright pioneered the use of bioidentical
estrogens and DHEA in daily medical practice. He
has authored 11 books and publishes Nutrition
and Healing, a monthly newsletter with a worldwide
circulation of more than 100,000.
LifeExtension

SCI ENTI FI C ADVISORY BOARD
Aubrey de Grey, PhD, is a biomedical gerontologist and
Editor-in-Chief of Rejuvenation Research, the worlds highest-
impact peer-reviewed journal focused on intervention in aging.
He received his BA and PhD from the University of Cambridge
in 1985 and 2000 respectively. Dr. de Grey is a Fellow of
both the Gerontological Society of America and the American
Aging Association, and sits on the editorial and scientic
advisory boards of numerous journals and organisations.
rn Adalsteinsson, PhD, holds a masters and doctorate
from the Massachusetts Institute of Technology (MIT). He
has specialized in human therapeutics including vaccines,
monoclonal antibodies, product development, nutraceuticals,
formulations, articial intelligence, hormones, and nutritional
supplementation. He has also authored articles and contributed
to peer-reviewed publications and served as an editor for the
Journal of Medicinal Food.
Russell L. Blaylock, MD, is a board-certied neurosurgeon,
author, and lecturer. He recently retired from his neurosurgical
practice to devote his time to nutritional studies and research.
He has written numerous journal articles and three books
(Excitotoxins: The Taste That Kills, Health and Nutrition
Secrets That Can Save Your Life, and Natural Strategies for
the Cancer Patient) and currently publishes a monthly
nutrition newsletter, The Blaylock Wellness Report.
John Boik, PhD, is the author of two books on cancer
therapy, Cancer and Natural Medicine (1996) and Natural
Compounds in Cancer Therapy (2001). He obtained his
doctorate at the University of Texas Graduate School of Bio-
medical Sciences with research at the MD Anderson Cancer
Center, focusing on screening models to identify promising
new anticancer drugs. He conducted his postdoctoral training
at Stanford University Department of Statistics. He is currently
president of New Earth BioMed, a nonprot cancer research
corporation that studies mixtures of natural products.
Eric R. Braverman, MD, is director of the Place for Achiev-
ing Total Health (PATH Medical and the PATH Foundation) in
New York City. Dr. Braverman received his BA from Brandeis
University Summa Cum Laude/ Phi Beta Kappa and his MD
from New York University Medical School with honors. He is
the author of Younger You (2006) and Younger Thinner You
(2009) and over 100 research papers and is clinical assistant
professor of integrative medicine in the Department of Neuro-
surgery at Cornell Weill Medical College, as well as a lecturer
on mild cognitive decline.
Frank Eichorn, MD, is a urologist specializing in pros-
tate cancer for 10 years. He has a private practice in Bad
Reichenhall, Germany, and is prostate cancer consultant at
the Urologische Klinik Castringius, Planegg, Munich. In his
integrative approach to prostate cancer he is working together
with an international network of experts to improve treatment
outcomes for prostate cancer patients with a special focus on
natural and translational medicine.
Deborah F. Harding, MD, is founder of the Harding Anti-
Aging Center. She is double board-certied in internal medicine
and sleep disorder medicine. She also earned the Cenegenics
certication in age management medicine. She is a faculty
member of the new University of Central Florida Medical School.
Steven B. Harris, MD, is president and director of research
at Critical Care Research, a company that grew out of 21st
Century Medicine in Rancho Cucamonga, CA. Dr. Harris
participates in groundbreaking hypothermia, cryothermia, and
ischemia research. His research interests include antioxidant
and dietary-restriction effects in animals and humans.
Stanley W. Jacob, MD, is Gerlinger Distinguished Professor,
Department of Surgery, Oregon Health and Science University.
He has authored 175 scientic articles and 15 books and
holds 3 patents, including the initial patent on the therapeutic
implications of dimethyl sulfoxide (DMSO).
Richard Kratz, MD, DSci, is clinical professor of ophthalmol-
ogy at the University of California, Irvine, and the University
of Southern California (Los Angeles). Dr. Kratz pioneered the
cataract-removal technique called phacoemulsication and
developed intraocular lenses to replace the crystalline lens. He
is currently involved in projects relating to glaucoma, cataract
extraction, and facilitating eyesight for the totally blind.
Peter H. Langsjoen, MD, FACC, is a cardiologist special-
izing in congestive heart failure, primary and statin-induced
diastolic dysfunction, and other heart diseases. A leading
authority on coenzyme Q10, Dr. Langsjoen has been involved
with its clinical application since 1983. He is a founding mem-
ber of the executive committee of the International Coenzyme
Q10 Association, a fellow of the American College of Cardiol-
ogy, and a member of numerous other medical associations.
Ralph W. Moss, PhD, is the author of books such as
Antioxidants Against Cancer, Cancer Therapy, Questioning
Chemotherapy, and The Cancer Industry, as well as the
award-winning PBS documentary The Cancer War.
Dr. Moss has independently evaluated the claims of various
cancer treatments and currently directs The Moss Reports, an
updated library of detailed reports on more than 200 varieties
of cancer diagnoses.
Michael D. Ozner, MD, FACC, FAHA, is a board-certied
cardiologist who specializes in cardiovascular disease preven-
tion. He serves as medical director for the Cardiovascular
Prevention Institute of South Florida and is a noted national
speaker on heart disease prevention. Dr. Ozner is also
author of The Great American Heart Hoax and The Miami
Mediterranean Diet (2008, Benbella Books). For more
information visit www.drozner.com.
Robert Pastore, PhD, CNS, is a clinical nutritionist practic-
ing in New York City. Due to his thorough nature and focus
on organic chemistry and biochemistry, his colleagues have
termed his practice forensic nutrition. He is a member of Har-
vard Medical School Postgraduate Association, the American
College of Nutrition, New York Academy of Sciences, and the
American Association of Pharmaceutical Scientists.
Jonathan Treasure, AHG, MNIMH, originally a medical
sciences graduate from Cambridge University, he studied
herbal medicine at the UK School of Phytotherapy. His clinical
specialty is integrative botanical medicine for cancer, and his
principal research interest is herb/drug interactions.
Jonathan V. Wright, MD, is medical director of the Tahoma
Clinic in Renton, WA. He received his MD from the University
of Michigan and has taught natural biochemical medical treat-
ments since 1983. Dr. Wright pioneered the use of bioidenti-
cal estrogens and DHEA in daily medical practice. He has
authored 11 books and publishes Nutrition and Healing, a
monthly newsletter with a worldwide circulation of more than
100,000.
Scientists have known that when blood sugar
combines with fats and proteins the result is known
as glycation which produces accelerated aging.
1

Even those with blood sugar levels within normal
range experience the impact of systemic glycation on
a daily basis.
2
Fortunately, researchers in Japan developed
benfotiamine, a unique form of vitamin B1 (thiamine)
that supports healthy blood sugar metabolism
and protects against glycation.
3-5
What makes
benfotiamine especially efective is that unlike
ordinary vitamin B1, it is fat-soluble and can easily
penetrate the inside of cells.
6
Regular vitamin B1 is
water soluble and has a short lifespan in the body.
7

Mega Benfotiamine helps inhibit the formation
of advanced glycation end products (AGEs), to maintain
healthy endothelial, retinal, kidney and nerve cell
function.
8-12
Each capsule provides 250 milligrams of
benfotiamine and 10 milligrams of vitamin B1 (as
thiamine HCl).
The suggested daily dose is one to four capsules,
taken with or without food. A bottle containing
120 vegetarian capsules of 250 milligrams
Mega Benfotiamine retails for $30. If a
member buys four bottles, the price is reduced
to only $20.25 per bottle. Contains rice.
References
1. Drugs & Aging. 1996 Aug;9(2):69-77.
2. J Biol Chem. 2011 Dec 30; 286(52): 443506.
3. J. Biochem. 1954;41:219-44.
4. Genes Nutr. 2012 Jul;7(3):459-69.
5. Diabetes Metab Res Rev. 2004 Jul-Aug;20(4):330-6.
6. Acta Diabetol. 2001;38(3):135-8.
7. Nutr Res. 2010 Mar;30(3):171-8.
8. Nat Med. 2003 Mar;9(3):294-9.
9. Diabetes Care. 2006 Sep;29(9):2064-71.
10. Ann N Y Acad Sci. 2005 Jun;1043:777-83.
11. Pharmacol Res. 2010 Jun;61(6):482-8.
12. Ann N Y Acad Sci. 2005 Jun;1043:784-92.

To order MEGA BENFOTIAMINE,
call 1-800-544-4440
or visit www.LifeExtension.com
PROTECT AGAINST
SYSTEMIC GLYCATION
MEGA BENFOTIAMINE
ITEM #00925
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The Mitochondrial Energy Optimizer formula provides 150 mg of benfotiamine,
which when combined with other anti-glycation agents like carnosine and
pyridoxal-5-phosphate provides substantial protection at diferent checkpoint
opportunities in the glycation process. The Mitochondrial Energy Optimizer can be
viewed on the inside back cover of this months issue.
AS WE SEE IT
Science
by
Ambush
BY WI LLIAM FALOON
In 1938, Orson Welles fictional broadcast of Earth being invaded by
Martians was aired on CBS Radio. The resulting hysteria drove over a
million Americans to flee into hiding or force open armories so citizens
could defend against the attacking space monsters.
CBSs on-air dramatization of the H.G. Wells novel War of the
Worlds is historys most effective manipulation (by a single broadcast)
of the perception of reality in the consciousness of the masses.
This kind of chaos is not confined to last century. In September 2012,
the American Medical Association published a study by three Greek
doctors that proclaimed there is no value to recommending omega-3
supplements to cardiac patients.
1
Consumers were misled as the media inaccurately represented the
studys findings. This manipulation of reality will cause millions of
needless deaths throughout the world if not retracted.
I titled this piece Science by Ambush because the media turned
this flawed report into headline news and, in the process, failed to
include an objective rebuttal.
This article will expose flaws that discredit this studys conclu-
sions, the medias inappropriate portrayal of this study, the publics lack
of knowledge about how to use omega-3s, and the inability of most
people to understand that the successful treatment of atherosclerotic
disease requires more than one intervention. >
AS WE SEE IT
AS WE SEE IT
The Raging Inferno
If you had to rely on the
medias sensationalist report-
ing of the study published in the
Journal of the American Medical
Association (JAMA), you might
think there is no value to omega-3
supplementation.
Yet the JAMA study itself
reported on published benets of
sh oil as follows:
1
Substantial reduction in
triglycerides (even the FDA
recognizes this benet).
Reduction in serious
arrhythmias (irregular
heartbeat).
Decreased platelet aggrega-
tion (protects against clots
forming in arteries).
Modest reduction in blood
pressure.
There are other ways that sh
oil helps prevent heart attack,
such as protecting against inam-
mation, but just the four benets
outlined in the JAMA study itself
provide a scientic rationale for
anyone concerned about vascu-
lar health to ensure adequate
omega-3 intake.
What most physicians do
not understand, however, is the
magnitude of damage that is
already present in the inner arte-
rial lining of cardiac patients.
These patients already suffered a
heart attack or developed prob-
lems that required intervention
with stents, bypass surgery, and/
or aggressive drug therapy, and
thus had signicant pre-existing
arterial disease.
In my previous career, I was
involved in thousands of autopsy
cases where I could see and feel
the effects of aging in the form of
blocked and hardened arteries
throughout a deceased persons
body. There was often such severe
arterial occlusion that my col-
leagues would question how the
person lived as long as they did.
Arterial disease begins at birth
and progresses as we mature.
Over a certain age, many people
become victims of accelerated
atherosclerosis whereby a cor-
onary artery that was only 30%
occluded three years earlier rap-
idly becomes 90100% blocked.
What is remarkable is how
much damage can be inicted
to our vital circulatory system
before death ensues. The point
Im getting at is that by the time
American Medical
Association
Attack on Fish Oil
The September 12, 2012, issue
of the Journal of the American
Medical Association published
a data analysis of 20 self-selected
prior studies on sh oil and vascu-
lar disease.
Their ndings showed that in
response to a modest daily intake
of sh oil (only 1,370 milligrams
of EPA/DHA), the following posi-
tive effects were observed:
1
9% reduction in cardiac
death
13% reduction in sudden
death
11% reduction in myocar-
dial infarction (heart attack)
4% reduction in all-cause
mortality
The authors of this study
claimed that the data they assem-
bled did not have statistically
significant association and
therefore no likely benets were
observed in the 20 studies they
reviewed where a modest dose of
sh oil was used for a short treat-
ment term (median 2 years).
Not all participants in this anal-
ysis took sh oil capsules. Some
of the estimated daily EPA/DHA
intake was based on food guid-
ance counseling. Omitted from
the authors analysis were studies
showing more robust heart attack
reduction in response to higher
doses of sh oil used by enlight-
ened consumers today.
The authors nonetheless con-
cluded that their observations do
not justify the use of omega-3 as a
structured intervention in every-
day clinical practice or guide-
lines supporting dietary omega-3
administration.
1

people manifest outward signs of
vascular disease (such as needing
a coronary stent), there is a rag-
ing inferno going on inside their
arterial walls that is not going
to be extinguished with sh oil
alone.
Most of the subjects in these
studies analyzed by JAMA had
already suffered a heart attack or
coronary artery blockage and the
sh oil was being used for second-
ary prevention purposes. At this
advanced stage, the window had
long ago closed for a modest dose
of any treatment to be effective.
To clarify, lets say you are bar-
becuing outdoors and you acci-
dentally ignite a bush next to your
house. You turn your garden hose
on full blast and rapidly extin-
guish the re. Based on your expe-
rience, you can categorically state
that garden hoses are effective in
preventing houses from burning
down.
Now lets say you come home
and nd your house engulfed in
ames. You take your garden hose
and turn it only half-way on, but
your house burns to the ground
anyway. At that point you state
that garden hoses are useless in
preventing houses from being
destroyed by re.
While there is solid evidence
to document that sh oil is more
effective than a garden hose in
this analogy, what JAMA has in
essence published are selected
efforts of mainstream doctors
using an inadequate dose of sh
oil, over too short a time period,
to put out a raging inferno going
on inside the arteries of cardiac
patients.
Comparison
With Statin Drugs
By reducing LDL cholesterol,
statin drugs have been shown to
lower heart attack risk.
2

A healthy person without arte-
rial disease can sometimes get by
with using a modest dose (10 mg/
day) of a drug like simvastatin.
Along with healthier dietary pat-
terns, this can slash LDL levels
from a dangerous 140 mg/dL to
the safe range for healthy people
now recognized to be under 100
mg/dL.
This dose of statin drug, how-
ever, will not reduce LDL-C levels
aggressively enough for those with
pre-existing arterial disease. These
individuals need to get their LDL
under 70 mg/dL, which, in the
example cited, may require a daily
dose of simvastatin of 80 mg per
day. It is at these high doses that
statin drugs inict most of their
nasty side effects.
Since the medical establish-
ment recommends that those with
pre-existing arterial disease take
higher doses of statin drugs, it
is ludicrous to think that a mod-
est dose of sh oil would show a
signicant effect on the relatively
unhealthy patient populations
analyzed in the JAMA report.
How Much EPA/DHA
Should Be Consumed
Each Day?
About 60% of your brain mass
consists of fats that comprise vital
cell membranes.
3
DHA is the dom-
inant omega-3 fat in healthy brain
cells. Since people cannot make
DHA internally, it has to come
from diet or supplemental sources.
For the JAMA authors to state
that there is no place in clinical
practice to encourage omega-3
intake borders on medical neg-
ligence. The fact that they hand-
selected studies where inadequate
doses of omega-3s were used hints
at a sizeable bias against non-drug
approaches to treating disease.
Based on the totality of evi-
dence showing multiple health
benets associated with greater
omega-3 intake, Life Extension

long ago recommended that mem-
bers should supplement with
2,400 mg of EPA/DHA each day.
This recommendation was based
on the three assumptions listed on
the next page.
AS WE SEE IT
average daily intake of only 1,370
mg of EPA/DHA in individuals
who mostly suffered signicant
pre-existing arterial disease, i.e.,
atherosclerosis. In fact, half of
the studies included in the meta-
analysis used an omega-3 dose of
less than 1,000 mg daily. This
amount of EPA/DHA is too low to
reverse the underlying progression
of atherosclerosis that most of the
study group suffered.
The unhealthy study subjects
used in the JAMA study consisted
of population groups in countries
throughout the world. Based on
what the JAMA authors wrote,
these study subjects presumably
consumed less than 58% of the
minimum amount of EPA/DHA
that Life Extension members take.
Some of these population groups
took no other supplement to pro-
tect against heart attack since
these nutrients are not openly sold
in those countries.
I use the term presumably
consumed in the previous para-
graph because it is not clear that
study subjects even got 58% of the
EPA/DHA they needed. The JAMA
study results were based either on
patients instructed to take sh oil
capsules or patients provided with
dietary guidance counseling.
This kind of diet counseling is
notoriously unreliable, especially
over the longer term when people
tend to gravitate back to unhealthy
dietary habits. The same is often
true of people who are told to swal-
low large sh oil capsules by their
doctors but fail to comply for all
kinds of reasons including the fact
that they dont like swallowing
large capsules!
As you will read in the sidebar
on page 13, the ndings from the
JAMA study (where lower-dose
EPA/DHA was inconsistently used
on unhealthy patient groups for
a relative short term) have noth-
ing to do with what health-con-
scious people are doing today to
guard against heart attack, which
includes taking the proper dose of
EPA/DHA each day.
Why Most Consumers
Dont Benet From Fish Oil
The environment that we at Life
Extension exist in is far removed
from the mainstream. We are
privileged to interact with excep-
tional physician/scientists and the
worlds most knowledgeable health
consumers (i.e., our members).
Recently, we found ourselves so
out of touch with the mainstream
that we went to considerable
expense to empanel outside focus
groups to educate us on how the
lay public thinks about nutrition
and their health. To participate in
these focus groups, people had to
be health-conscious consumers
who used dietary supplements.
The level of ignorance uncovered
by these focus group sessions
was appalling.
Virtually all the focus group par-
ticipants had heard good things
about omega-3s, but they had no
idea how much they were taking or
how much EPA/DHA they should
use. Most of them claimed to
1. Foundation members are
health-conscious individuals
who consume food sources
of omega-3s like cold-water
sh, thus providing greater
average intake of omega-3
than 2,400 mg daily.
2. Foundation members take
annual blood tests that
measure triglyceride levels.
If triglycerides are over 100
mg/dL of blood, there would
be a greater consumption of
omega-3s, along with life-
style, drug, and other supple-
ment alterations. (Some
people, for instance, require
daily doses of 4,800 mg of
EPA/DHA to suppress artery-
clogging triglycerides.)
3. Findings from Omega Score
blood test results show that
at least 2,400 mg a day
of EPA/DHA is needed to
achieve optimal omega-3
blood levels. (Some people
require more than 2,400 mg
of omega-3s to boost blood
levels.)
The media used the JAMA study
to create headlines like Fish oil
supplements dont prevent heart
attacks, study says.
4
The JAMA
report, however, was based on an
AS WE SEE IT
purchase omega-3 supplements on
a somewhat irregular basis, usu-
ally when they saw them displayed
on a pharmacy or supermarket
shelf. Some claimed to take one
sh oil capsule daily while others
claimed to take them when they
would remember.
If a survey were conducted to
identify people who took omega-3
supplements, virtually every par-
ticipant in these focus groups
would have been categorized as
an omega-3 supplement user. Yet
virtually none of them were tak-
ing the potency needed to stave off
heart disease.
When conventional doctors and
the media claim that people dont
benet from supplements, they are
often correct in that most consum-
ers have no idea how much of what
supplement they should take to
stave off disease. This should not
dissuade knowledgeable individu-
als, who know what to take and
have the discipline to do so on a
consistent basis, from following
an evidence-based program that
includes at least 2,400 mg of sup-
plemental EPA/DHA daily along
with healthy dietary patterns.
Good Ratings for the Media
Just imagine being in the
news business where every day
you have to generate attention-
grabbing headlines to sell newspa-
pers or attract viewers.
You see a study published in the
Journal of the American Medical
Association meant for doctors,
but since it relates to a popular
dietary supplement, you have a
sound-bite headline for the day. No
need to look at details such as
the JAMA study stating that even
subjects who consumed inad-
equate doses of sh oil appeared
to derive some reductions in heart
attack risk.
Just hype up the JAMA studys
conclusion and you have your-
self a startling headline that most
of your audience will want to
know more about, i.e. ambush
journalism.
This is how the general public
makes their life-and-death deci-
sions, which is rather pathetic con-
sidering we live in a world where
most everyone has Internet access
to assess the facts for themselves.
AS WE SEE IT
Methodology Problems
with the JAMA Meta-Analysis
Flaws in the design of the JAMA meta-analysis of 20 self-selected
studies call its findings into question for the following reasons:
Inclusion of trials of poor methodological quality. Nearly half
of the sample size of the meta-analysis came from two open-label trials.
Open-label trials allow both the subjects and researchers to know what
treatment is being provided in the study. This type of study is considered
to be of inferior quality compared to double-blind, placebo-controlled tri-
als, where researchers and subjects do not know which intervention the
subjects are receiving.
High level of variability in the trials cardiovascular event
rates & baseline risk. There was a high degree of variability in the
baseline cardiovascular risk and cardiovascular event rates in the tri-
als included in this meta-analysis. This means it was difficult to assess
which subjects were at greater risk of heart attack at baseline. If those
given fish oil, for instance, also had higher vascular risk at the beginning
of the study, then the validity of the data is severely compromised.
Limited number of studies included. Only 20 of 3,635 studies
the authors examined were used in this meta-analysis. This provides a
very limited view of the research that has been conducted on fish oil for
cardiovascular disease.
There has been a significant amount of research conducted on the
cardiovascular benefits of fish oil beyond what was selected for the
JAMA analysis. For example, in a PubMed.gov (U.S. National Library of
Medicine) search for clinical trials of fish oil and triglycerides, there
were over 500 results.
take months, and some patients
are aficted with lifetime impair-
ments such as memory loss,
chronic inammation, and depres-
sion. Coronary artery stenting has
become more common in recent
years, but this is not a cure for sys-
temic atherosclerosis.
The scientic literature reveals
that atherosclerosis is associated
with high blood levels of C-reactive
protein,
18-26
insulin,
27-32
iron,
33-36
LDL,
37-42
homocysteine,
25,26,43-46

fibrinogen,
25,47-50
and triglycer-
ides,
51-53
along with low levels of
HDL
54-56
and testosterone
57-62
(in
men). Optimizing blood levels of
these substances can dramatically
reduce heart attack and stroke risk.
Cardiologists Only
Partially Correct
Atherogenic Risk Factors
Prescribing a statin drug is what
doctors typically do to prevent and
treat coronary atherosclerosis.
Cholesterol and LDL, however, are
only two players in the atheroscle-
rosis process.
There are now two fish oil
drugs approved by the FDA to
lower triglycerides. Fish oil also
protects against atherosclero-
sis by reducing inammation
63-71
and inhibiting abnormal platelet
aggregation.
72-76
But even sh oil
and statin drugs are not going
to adequately counteract all fac-
tors involved in coronary artery
disease.
Mainstream cardiologists fail
to appreciate that coronary ath-
erosclerosis is a sign of systemic
arterial dysfunction requiring
aggressive therapy to correct.
To read more about the steps
you need to take to reduce your
odds of being stricken with a vas-
cular disorder, refer to the articles
on pages 68 and 78 of this months
issue.
How We Protect You
Life Extensions annual Blood
Test Super Sale commences April
1, 2013. The reason I am alerting
you early is to enable you to start
preparing for your annual compre-
hensive blood tests.
Make sure, for example, that
you take your omega-3 and vita-
min D supplements with the
heaviest meal of the day. These
fat-soluble nutrients absorb far
better when consumed with the
meal of the day that contains the
most fat. A problem we fear occurs
in clinical studies is that partici-
pants take fat-soluble nutrients on
relatively empty stomachs, which
leads to poor absorption and sub-
sequent failure to derive benets.
The extensive focus group
sessions we conducted reveal the
typical consumer has no idea what
they need to do to protect against
the degenerative diseases of aging.
We provide our members with
every means of support possible,
from access to knowledgeable
health advisors and low-cost com-
prehensive blood testing, to accu-
rately reported scientic data and
ongoing clinical research.
The public, on the other hand,
is left to rely on a sound-bite fren-
zied news media for health data,
which often involves outing a
scary medical headline without
assessing a storys veracity. I call
this science by ambush because
it blind sides an established prin-
ciple, and denies an opportunity
for meaningful rebuttal!
For longer life,
William Faloon
Bottom Line: The subjects in
the JAMA report were people with
existing heart problems, the dos-
ages they were taking were too
small, and they probably were not
taking the additional supplements
that have long been recommended
to generate a multi-pronged attack
against heart disease.
What Do Humans
Need To Do To
Prevent Atherosclerosis?
The aging process damages
blood vessels even when conven-
tional risk factors such as cho-
lesterol and blood pressure are
within normal ranges.
Despite aggressive intervention
with diet, exercise, supplements,
and drugs, pathological changes
still occur in the arterial wall that
predispose aging adults to vascular
diseases. The encouraging news is
that validated methods have been
developed to address the underly-
ing reason why arteries become
occluded as people reach the later
stages of their lives.
For the past 40 years, the stan-
dard way to treat coronary ath-
erosclerosis has been to bypass
the blocked arteries. Recuperation
from coronary bypass surgery can
AS WE SEE IT
A coronary artery
with atherosclerosis
Atherosclerotic
plaque
Endothelium
A number of studies have indicated that higher
doses of fish oil leads to beneficial effects in prevent-
ing cardiovascular disease events or reducing risk fac-
tors. For example:
A randomized, placebo-controlled trial found 1,800
mg of combined EPA plus DHA was associated with
a 10% lower rate of cardiac events, 12% lower rate of
non-fatal infarctions, and an almost 11% lower rate of
cardiac deaths.
5
In a large intervention study, 18,000 patients were
randomized to receive either a statin medication alone
or a statin plus 1,800 mg of EPA-fish oil daily. After 5
years, those with a history of coronary artery disease
had a 19% lower rate of major coronary events in the
statin-plus EPA-fish oil group compared to the statin-
only group.
6
A randomized, double-blind, placebo-controlled
trial with chronic hemodialysis patients found that
1,700 mg of omega-3 fatty acids daily was associated
with a 70% reduction in the relative risk of myocardial
infarction.
7
A randomized, controlled trial using 3,300 mg of
EPA and DHA (and then a decreased dosage) found
a trend toward lower cardiovascular event occurrence
with fish oil supplementation. Seven cardiovascular
events occurred in the placebo group (not given fish
oil) while only two cardiovascular events occurred in
the fish oil-supplemented group during the study.
8
A meta-analysis with an average fish oil dose of
3,700 mg found lowered systolic blood pressure by
an average 2.1 mmHg and diastolic by 1.6 mmHg.
9
In a randomized trial with peripheral arterial dis-
ease patients, 2,000 mg of omega-3 fatty acids daily
resulted in a 49% improvement in flow-mediated dila-
tion, a marker of endothelial cell health.
10
In contrast to the findings of the JAMA meta-anal-
ysis, two important studies demonstrated significant
benefits with even moderate fish oil doses:
The GISSI-Prevenzione study (a large, randomized,
controlled trial) found that 1,000 mg/day of EPA and
DHA in 11,323 patients with a history of recent myo-
cardial infarction reduced the risk of total mortality
by 20% and sudden death by 45%.
11,12
The DART study a randomized, controlled trial
that examined the effects of advising 2,033 subjects
to increase dietary fatty fish revealed a 29% reduc-
tion in all-cause mortality compared with those not
advised.
13
The Journal of the American Medical Associ-
ation (JAMA) meta-analysis also conflicts with other
reviews of fish-oil research. Other meta-analyses have
demonstrated a reduced risk of cardiovascular disease
outcomes in those supplemented with omega-3 fatty
acids from fish oil. For example:
A 2009 meta-analysis of randomized, controlled tri-
als found that dietary supplementation with omega-3
fatty acids reduced the incidence of sudden cardiac
death in subjects with prior myocardial infarction.
14

Another 2009 meta-analysis of randomized, con-
trolled trials found that dietary supplementation with
omega-3 fatty acids reduced the risk of cardiovascular
death, sudden cardiac death, all-cause mortality, and
non-fatal cardiovascular events in patients with a his-
tory of certain cardiovascular events or risk factors.
15
A 2008 meta-analysis found a significant reduction
in death from cardiac causes with fish oil supplemen-
tation.
16
A 2002 meta-analysis of randomized, controlled tri-
als concluded that omega-3 fatty acids reduced over-
all mortality, mortality due to myocardial infarction, and
sudden death in patients with coronary heart disease.
17
Higher-Dose Fish Oil Provides Heart Benefits
AS WE SEE IT
13. Burr ML, Fehily AM, Gilbert JF, et al. Ef-
fects of changes in fat, sh, and bre in-
takes on death and myocardial reinfarc-
tion: diet and reinfarction trial (DART).
Lancet. 1989 Sep 30;2(8666):757-61.
14. Zhao YT, Chen Q, Sun YX, et al. Pre-
vention of sudden cardiac death with
omega-3 fatty acids in patients with
coronary artery disease: a meta-analysis
of randomized controlled trials. Ann
Med. 2009;41(4):301-10.
15. Marik PE and Varon J. Omega-3 dietary
supplements and the risk of cardiovas-
cular events: a systematic review. Clin
Cardiol. 2009;32(7):365-72.
16. Len H, Shibata MC, Sivakumaran S,
et al. Effect of sh oil on arrhythmias
and mortality: systematic review. BMJ.
2008;337:a2931.
17. Bucher HC, Hengstler P, Schindler C,
et al. N-3 polyunsaturated fatty acids in
coronary heart disease: a meta-analysis
of randomized controlled trials. Am J
Med. 2002;112(4):298-304.
18. Piechota W, Piechota W. Correlation of
high-sensitivity CRP concentration with
the extent of coronary atherosclerosis
in men with symptoms of ischemic
heart disease. Pol Merkur Lekarski. 2005
May;18(107):511-5.
19. Choi EY, Yan RT, Fernandes VR, et al.
High-sensitivity C-reactive protein as
an independent predictor of progressive
myocardial functional deterioration: the
multiethnic study of atherosclerosis. Am
Heart J. 2012 Aug;164(2):251-8.
20. Van Der Meer IM, De Maat MP, Hak
AE, et al. C-reactive protein predicts
progression of atherosclerosis mea-
sured at various sites in the arterial
tree: the Rotterdam Study. Stroke. 2002
Dec;33(12):2750-5.
21. Masood A, Jafar SS, Akram Z. Serum
high sensitivity C-reactive protein levels
and the severity of coronary athero-
sclerosis assessed by angiographic
gensini score. J Pak Med Assoc. 2011
Apr;61(4):325-7.
22. Ridker PM, Buring JE, Shih J, Matias
M, Hennekens CH. Prospective study of
C- reactive protein and the risk of future
cardiovascular events among apparently
healthy women. Circulation. 1998 Aug
25;98(8):731-3.
23. Auer J, Berent R, Lassnig E, Eber B.
C-reactive protein and coronary artery
disease. Jpn Heart J. 2002 Nov;43(6):
607-19.
24. Agmon Y, Khandheria BK, Meissner I, et
al. C-reactive protein and atherosclerosis
of the thoracic aorta: a population-
based transesophageal echocardio-
graphic study. Arch Intern Med. 2004 Sep
13;164(16):1781-7.
25. Ridker PM, Stampfer MJ, Rifai N. Novel
risk factors for systemic atherosclerosis:
a comparison of C-reactive protein, -
brinogen, homocysteine, lipoprotein(a),
and standard cholesterol screening as
predictors of peripheral arterial disease.
JAMA. 2001 May 16;285(19):2481-5.
26. Jarosz A, Nowicka G. C-reactive protein
and homocysteine as risk factors of
atherosclerosis. Przegl Lek. 2008 65(6):
268-72.
27. Bonora E, Kiechl S, Willeit J, et al. Insu-
lin resistance as estimated by homeosta-
sis model assessment predicts incident
symptomatic cardiovascular disease
in caucasian subjects from the general
population: the Bruneck study. Diabetes
Care. 2007 Feb;30(2):318-24.
28. Sundell J, Luotolahti M. Association
between insulin resistance and reduced
coronary vasoreactivity in healthy
subjects. Can J Cardiol. 2004 May
15;20(7):691-5.
29. Stochmal E, Szurkowska M, Czarnecka
D, et al. Association of coronary athero-
sclerosis with insulin resistance in pa-
tients with impaired glucose tolerance.
Acta Cardiol. 2005 Jun;60(3):325-31.
30. Takahashi F, Hasebe N, Kawashima E,
et al. Hyperinsulinemia is an indepen-
dent predictor for complex atheroscle-
rotic lesion of thoracic aorta in non-
diabetic patients. Atherosclerosis. 2006
Aug;187(2):336-42.
31. Stout RW. The relationship of abnormal
circulating insulin levels to atherosclero-
sis. Atherosclerosis. 1977 May;27(1):1-13.
32. Chien KL, Lee YT, Sung FC, Hsu HC,
Su TC, Lin RS. Hyperinsulinemia and
related atherosclerotic risk factors in
the population at cardiovascular risk:
a community-based study. Clin Chem.
1999 Jun;45(6 Pt 1):838-46.
33. Howes PS, Zacharski LR, Sullivan
J, Chow B. Role of stored iron in
atherosclerosis. J Vasc Nurs. 2000
Dec;18(4):109-14; quiz 115-6.
34. Chau LY. Iron and atherosclerosis. Proc
Natl Sci Counc Repub China B. 2000
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35. Kraml P, Potockova J, Koprivova H,
et al. Ferritin, oxidative stress and
coronary atherosclerosis. Vnitr Lek. 2004
Mar;50(3):197-202.
36. Minqin R, Watt F, Huat BT, Halliwell B.
Correlation of iron and zinc levels with
lesion depth in newly formed atheroscle-
rotic lesions. Free Radic Biol Med. 2003
Mar 15;34(6):746-52.
37. Montalcini T, Gorgone G, Federico D, et
al. Association of LDL cholesterol with
carotid atherosclerosis in menopausal
women affected by the metabolic syn-
drome. Nutr Metab Cardiovasc Dis. 2005
Oct;15(5):368-72.
38. Nissen SE, Tuzcu EM, Schoenhagen P,
et al. Effect of intensive compared with
moderate lipid-lowering therapy on pro-
gression of coronary atherosclerosis: a
randomized controlled trial. JAMA. 2004
Mar 3;291(9):1071-80.
39. Reed DM, Strong JP, Resch J, Hayashi T.
Serum lipids and lipoproteins as predic-
tors of atherosclerosis. An autopsy study.
Arteriosclerosis. 1989 Jul-Aug;9(4):560-4.
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6. Yokoyama M, Origasa H, Matsuzawa M,
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7. Svensson M, Schmidt EB, Jrgensen
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8. von Schacky C, Angerer P, Kothny W,
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9. Geleijnse JM, Giltay EJ, Grobbee DE, et
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10. Schiano V, Laurenzano E, Brevetti G, et
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11. Marchioli R, Barzi F, Bomba E, et al.
Early protection against sudden death
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Prevenzione. Circulation. 2002 Apr
23;105(16):1897-903.
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42. Ridker PM, Rifai N, Rose L, Buring JE,
Cook NR. Comparison of C-reactive
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43. Rasouli ML, Nasir K, Blumenthal RS,
Park R, Aziz DC, Budoff MJ. Plasma
homocysteine predicts progression of
atherosclerosis. Atherosclerosis. 2005
Jul;181(1):159-65.
44. Montalescot G, Ankri A, Chadefaux-
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and the extent of atherosclerosis in
patients with coronary artery disease.
Int J Cardiol. 1997 Aug 8;60(3):295-300.
45. Fernndez-Miranda C, Paz M, Aranda
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46. Cacciapuoti F. Lowering homocyste-
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impairments? Possible therapeutic be-
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47. Liu MY, Hu DY. The predictive value of
serum advanced brinogen and uric acid
for acute coronary event risk. Zhonghua
Yi Xue Za Zhi. 2006 Mar 14;86(10):
678-80.
48. Wattanakit K, Folsom AR, Chambless
LE, Nieto FJ. Risk factors for cardiovas-
cular event recurrence in the Atheroscle-
rosis Risk in Communities (ARIC)study.
Am Heart J. 2005 Apr;149(4):606-12.
49. Maresca G, Di Blasio A, Marchioli R, Di
Minno G. Measuring plasma brinogen
to predict stroke and myocardial infarc-
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Biol. 1999 Jun;19(6):1368-77.
50. Acevedo M, Foody JM, Pearce GL, Spre-
cher DL. Fibrinogen: associations with
cardiovascular events in an outpatient
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277-82.
51. Drexel H, Amann FW, Beran J, et al.
Plasma triglycerides and three lipopro-
tein cholesterol fractions are indepen-
dent predictors of the extent of coronary
atherosclerosis. Circulation. 1994
Nov;90(5):2230-5.
52. Bansal S, Buring JE, Rifai N, Mora S,
Sacks FM, Ridker PM. Fasting com-
pared with nonfasting triglycerides and
risk of cardiovascular events in women.
JAMA. 2007 Jul 18;298(3):309-16.
53. Nordestgaard BG, Benn M, Schnohr P,
Tybjaerg-Hansen A. Nonfasting triglyc-
erides and risk of myocardial infarc-
tion, ischemic heart disease, and death
in men and women. JAMA. 2007 Jul
18;298(3):299-308.
54. Toikka JO, Ahotupa M, Viikari JS, et al.
Constantly low HDL-cholesterol concen-
tration relates to endothelial dysfunction
and increased in vivo LDL-oxidation
in healthy young men. Atherosclerosis.
1999 Nov 1;147(1):133-8.
55. Viles-Gonzalez JF, Fuster V, Corti R,
Badimon JJ. Emerging importance of
HDL cholesterol in developing high-risk
coronary plaques in acute coronary
syndromes. Curr Opin Cardiol. 2003
Jul;18(4):286-94.
56. Spieker LE, Sudano I, Hurlimann D,
et al. High-density lipoprotein restores
endothelial function in hypercholes-
terolemic men. Circulation. 2002 Mar
26;105(12):1399-402.
57. Hak AE, Witteman JC, de Jong FH,
Geerlings MI, Hofman A, Pols HA. Low
levels of endogenous androgens increase
the risk of atherosclerosis in elderly
men: the Rotterdam study. J Clin Endo-
crinol Metab. 2002 Aug;87(8):3632-9.
58. English KM, Mandour O, Steeds RP, et
al. Men with coronary artery disease
have lower levels of androgens than men
with normal coronary angiograms. Eur
Heart J. 2000 Jun;21(11):890-4.
59. Tivesten A, Mellstrm D, Jutberger H,
et al. Low serum testosterone and high
serum estradiol associate with lower
extremity peripheral arterial disease
in elderly men. The MrOS Study in
Sweden. J Am Coll Cardiol. 2007 Sep
11;50(11):1070-6.
60. Dunajska K, Milewicz A, Szymczak J,
et al. Evaluation of sex hormone levels
and some metabolic factors in men with
coronary atherosclerosis. Aging Male.
2004 Sep;7(3):197-204.
61. Phillips GB, Pinkernell BH, Jing TY. The
association of hypotestosteronemia with
coronary artery disease in men. Arterio-
scler Thromb. 1994 May;14(5):701-6.
62. Jones RD, Nettleship JE, Kapoor D,
Jones HT, Channer KS. Testosterone and
atherosclerosis in aging men: purported
association and clinical implications.
Am J Cardiovasc Drugs. 2005;5(3):
141-54.
63. Kiecolt-Glaser JK, Belury MA, Andridge
R, Malarkey WB, Hwang BS, Glaser
R. Omega-3 supplementation lowers
inammation in healthy middle-aged
and older adults: a randomized con-
trolled trial. Brain Behav Immun. 2012
Aug;26(6):988-95.
64. Wu D, Han SN, Meydani M, Meydani
SN. Effect of concomitant consumption
of sh oil and vitamin E on production
of inammatory cytokines in healthy
elderly humans. Ann NY Acad Sci. 2004
Dec;1031:422-4.
65. Pischon T, Hankinson SE, Hotamis-
ligil GS, et al. Habitual dietary intake
of n-3 and n-6 fatty acids in relation
to inammatory markers among US
men and women. Circulation. 2003 Jul
15;108(2):155-60.
66. Mori TA, Beilin LJ. Omega-3 fatty acids
and inammation. Curr Atheroscler Rep.
2004 Nov;6(6):461-7.
67. James MJ, Gibson RA, Cleland LG.
Dietary polyunsaturated fatty acids and
inammatory mediator production. Am
J Clin Nutr. 2000 Jan;71(1 Suppl):
343S-8S.
68. Adam O, Beringer C, Kless T, et al. Anti-
inammatory effects of a low arachi-
donic acid diet and sh oil in patients
with rheumatoid arthritis. Rheumatol
Int. 2003 Jan;23(1):27-36.
69. Lopez-Garcia E, Schulze MB, Manson
JE, et al. Consumption of (n-3) fatty
acids is related to plasma biomarkers of
inammation and endothelial activation
in women. J Nutr. 2004 Jul;134(7):
1806-11.
70. Lorenz R, Weber PC, Szimnau P,
Heldwein W, Strasser T, Loeschke K.
Supplementation with n-3 fatty acids
from sh oil in chronic inammatory
bowel disease: A randomized, placebo-
controlled, double-blind cross-over trial.
J Intern Med Suppl. 1989;225(731):
225-32.
71. Foitzik T, Eibl G, Schneider P, Wenger
FA, Jacobi CA, Buhr HJ. Omega-3 fatty
acid supplementation increases anti-
inammato ry cytokines and attenuates
systemic disease sequelae in experimen-
tal pancreatitis. J Parenter Enteral Nutr.
2002 Nov-Dec;26(6):351-6.
72. Nomura S, Kanazawa S, Fukuhara S.
Effects of eicosapentaenoic acid on
platelet activation markers and cell
adhesion molecules in hyperlipidemic
patients with Type 2 diabetes mellitus.
J Diabetes Complications. 2003 May-
Jun;17(3):153-9.
73. Mori TA, Beilin LJ, Burke V, Morris J,
Ritchie J. Interactions between dietary
fat, sh, and sh oils and their effects on
platelet function in men at risk of car-
diovascular disease. Arterioscler Thromb
Vasc Biol. 1997 Feb;17(2):279-86.
74. Abeywardena MY, Head RJ. Longchain
n-3 polyunsaturated fatty acids and
blood vessel function. Cardiovasc Res.
2001 Dec;52(3):361-71.
75. Thorngren M, Gustafson A. Effects of
11-week increases in dietary eicosapen-
taenoic acid on bleeding time, lipids,
and platelet aggregation. Lancet. 1981
Nov 28;2(8257):1190-3.
76. Vanschoonbeek K, Feijge MAH, Paquay
M, et al. Variable hypocoagulant effect
of sh oil intake in humans: modulation
of brinogen level and thrombin genera-
tion. Arterioscler Thromb Vasc Biol. 2004
Sept;24(9):173440.
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6. J Vet Pharmacol Ther. 2005 Aug,28(4):385-90.
/. J Vet Pharmacol Ther. 200/ 1un,30(3):2/5-8.
8. Toxicol Mech Methods. 200/,!/(4):!89-96.
9. J Anim Physiol Anim Nutr (Berl). Lpub 20!! May 30.
!0. J Vet Pharmacol Ther. 2009 Dec,32(6):5//-84.
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I N THE NEWS I N THE NEWS
I N THE NEWS
Meta-analysis Links
Increased Magnesium Intake
with Fasting Glucose and
Insulin Reductions
The results of a meta-analysis
published in the Journal of
Nutrition reveal an asso-
ciation between diets that
include higher amounts
of magnesium with lower
blood levels of fasting
glucose and insulin.*
Researchers sought to
determine the inuence
of genetic variations asso-
ciated with glycemic traits
or magnesium metabolism on
fasting glucose and insulin levels,
which are elevated in metabolic syndrome
and type II diabetes. They analyzed data from up
to 52,684 nondiabetic men and women who partic-
ipated in 15 studies. Participants were genotyped
for up to 25 single nucleotide polymorphisms
related to fasting glucose, insulin, or magnesium.
Reductions in both fasting glucose and fast-
ing insulin were observed in association with
increased magnesium.
Editors Note: The authors concluded that, Their results indi-
cate that higher dietary magnesium intake is inversely associated
with fasting glucose and fasting insulin in individuals free of
diabetes.
D. Dye
* J Nutr. 2013 Jan 23.
Review Explores Effects of
Curcumin on Life Span
A review published online recently in the jour-
nal BioFactors documents a benet for curcumin,
a compound that occurs in the spice turmeric, in
extending the life of several species.*
In a study involving the roundworm C. elegans,
growth media containing a low concentration of
curcumin increased mean (average) life span by
39% and maximum life span by 21.4%.
In a study with fruit ies, which generally sur-
vive an average of 64 days, an increase of mean
life span to 80 days occurred in curcumin-fed
ies. Another study involving two strains of ies
found varying effects of curcumin in male and
female ies, with females of one strain and males
of another strain experiencing an extension in life
span. A third y study also revealed a variation
in male and female response to
curcumin, although the com-
pound was shown to extend
life in both genders.
Editors Note: The curcumin
metabolite tetrahydrocurcumin
has also been associated with
life span extension. In male
mice supplemented with the
curcumin metabolite beginning
at the age of 13 months, mean
life span was increased by an
average of 84 days in comparison
with unsupplemented mice.
D. Dye
* Biofactors. 2013 Jan 17.
I N THE NEWS
Heart Attack Risk Lower Among
Women with High Anthocyanin Intake
An article in a recent issue of Circulation reported the nding
of a decrease in the risk of myocardial infarction in women with a
high intake of anthocyaninsavonoids that occur in signicant
amounts in such foods as blueberries and strawberries.*
The study included 93,600 women between the ages of 25
and 42 upon enrollment in the Nurses Health Study II in 1989.
Dietary questionnaires completed every four years beginning in
1991 provided information on the intake of anthocyanins. The
participants were followed for 18 years, during which 405 heart
attacks occurred.
Among women whose intake of anthocya-
nins was among the top one-fth of subjects,
there was a 32% lower risk of heart attack
in comparison with those whose intake
was among the lowest fth.
Editors Note: The authors concluded that, Bioac-
tive compounds present in red and blue fruits and
vegetables commonly consumed in the habitual diet
may be associated with a reduced risk of myocardial
infarction in young and middle-aged women.
D. Dye
* Circulation. 2013 Jan 15;127(2):188-96.
Study Conrms CoQ10
Decline in Statin-Treated Patients
The Journal of the American College of Cardiology published the
nding of Danish researchers of reductions in glucose tolerance
and coenzyme Q10 levels in men treated with simvastatin, one of
several statin drugs commonly prescribed to lower cholesterol.*
The current study included ten individuals treated for high cho-
lesterol with simvastatin for at least one year and ten healthy con-
trol subjects. Participants underwent oral glucose tolerance tests,
muscle biopsies, and blood testing for numerous factors. Four of
those in the simvastatin group reported muscle pain, compared
to none of the controls. Among simvastatin-treated subjects, glu-
cose levels were signicantly higher during two-hour oral glucose
tolerance testing in comparison with untreated controls. When
tissue biopsy results were compared, CoQ10 and the antioxidant
enzymes catalase, manganese superox-
ide dismutase, and glutathione peroxi-
dase were lower in those treated with
simvastatin (Zocor
).
Editors Note: While statin drugs are of benet to
millions of people at risk for cardiovascular events,
their effect on coenzyme Q10, an important mito-
chondrial cofactor, has not been well publicized in
mainstream medical media. (Mitochondria are the
cells energy-producing organelles.)
D. Dye
* J Am Coll Cardiol. 2013 Jan 8;61(1):44-53.
Grape Seed Extract
Goes After Aggressive
Cancer Cells
An article published in the
journal Cancer Letters reveals
a potent effect for grape seed
extract against colorectal can-
cer in experiments involving
cultured cancer cells. The nd-
ings indicate a benecial effect
for grape seed extract that
increases with higher stage
cancer.*
Molly Derry of the
University of Colorado and
her associates tested the
effect of grape seed extract in
colorectal cancer cell lines in
various stages of disease. They
observed an increase in several
of grape seed extracts antican-
cer mechanisms in association
with increasing cancer stage.
The effect is in sharp contrast
with that of chemotherapy,
which becomes less potent
in association with increased
metastatic potential.
The discovery is of signi-
cance in view of the increased
prevalence of colorectal can-
cer in Western societies, cou-
pled with the fact that many
of those diagnosed are at an
advanced stage of cancer.
Editors Note: No harmful effects
from the compound occurred in
healthy cells.
D. Dye
* Cancer Lett. 2012 Dec 22.

I N THE NEWS
Calcium Supplementation Increases Fat Loss in
Obese and Overweight Young Adults
In an article published in Nutrition Journal, researchers in
China report a benecial effect for supplementation with calcium
and vitamin D in reducing the body fat of overweight and obese
college students.*
The trial included 43 men and women with a body mass index
(BMI) of 24 or higher. Participants were randomized to receive
an energy restricted diet supplemented with 600 mg of elemental
calcium and 125 IU vitamin D3, or an unsupplemented diet for
12 weeks.
While the amount of weight lost by both groups was similar, a
signicantly greater reduction in fat mass loss and fat percentage
occurred in the participants that received calcium in comparison
with unsupplemented subjects. Men and women who received
calcium and vitamin D experienced a 53.6%
greater decrease in fat mass loss than the con-
trol subjects, and had a greater reduction in
visceral fat mass and fat area.
Editors Note: Among other mechanisms of
body fat reduction, a calcium rich diet has been
demonstrated to increase fat oxidation and fat cell
apoptosis while reducing lipid absorption. Future
research in this area should be oriented toward a
better understanding of the doseresponse effect of
calcium supplementation (with or without vitamin
D) on weight management by administering differ-
ent dosages of this mineral, the authors conclude.
D. Dye
* Nutr J. 2013 Jan 8;12(1):8.

Life Extension
Products
Receive Top Awards!
Once again, Life Extension has received top ratings in
ConsumerLab.coms annual survey! Below are the areas in which
Life Extension took home the number one ranking:
I N THE NEWS
Curcumin Shows
Promise Easing
Arthritis Pain
In the medical journal
Phytotherapy Research, two
researchers, one from the
Nirmala Medical Centre in
India and the other from
Baylor Research Institute and
the Sammons Cancer Center
in Texas, published their work
on curcumin.* They showed
that curcumin is more effec-
tive than the common anti-
inflammatory medication
diclofenac for the pain associ-
ated with mild, active rheuma-
toid arthritis.
In the study, rheumatoid
arthritis patients taking cur-
cumin for eight weeks had a
44% reduction in pain symp-
toms, while those taking diclof-
enac had a 42% reduction. It
may not seem like there is a
big difference between cur-
cumin and diclofenac, but the
difference was signicant.
Interestingly, the curcumin
group also had a greater
reduction in overall inamma-
tion (rheumatoid arthritis may
have slightly improved) com-
pared to the diclofenac group.
Most importantly, there were
no adverse events with cur-
cumin.
This was an initial study,
but was well controlled and
randomized. Larger clinical
trials, however, are needed to
conrm these results.
D. Dye
* Available at: http://www.daily-
herald.com/article/20120416/
entlife/704169972/. Accesssed January.
28, 2013.
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Curcumin is the health-promoting
trace compound derived from the
Indian spice turmeric. But not all
turmeric is alike.
The curcumin found in the vast
majority of dietary supplements is
derived from turmeric that is nutri-
tionally inferior.
Why? Almost all growers harvest
turmeric at the point when the tur-
meric root turns its signature yellow
color, but before it has fully matured.
The turmeric root requires more
time in the ground for highly bene-
cial phytonutrients called curcumi-
noids and sesquiterpenoids to attain
peak concentrations.
Life Extension
s Super Bio-
Curcumin
derives from turmeric

that is grown with organic practices,
cultivated to maturity, then spe-
cially transported and processed to
preserve and deliver the roots most
complete nutritional prole.
In recent studies comparing the
eects of standard curcumin against
turmeric extracts comparable to
Super Bio-Curcumin
, researchers
observed:
1,2
Nearly twice the support for
immune health.
Approximately twice the support
for inammatory issues.
Almost double the antioxidant
support.
A separate study indicated that an
antioxidant-rich curcumin extract
3

provided powerful support for heart
health.
Unrivaled Potency and
Absorbability with BCM-95
Curcumin is neither absorbed nor

retained well in the blood, which is
another challenge facing those who
wish to maximize its benets.
The highly popular Super Bio-
Curcumin
uses BCM-95
, a pat-
ented, bioenhanced preparation of
curcumin. It has been shown to
reach up to 7 times higher concen-
tration in the blood than standard
curcumin.
4

The graphs on this page illustrate
that one 400 mg vegetarian capsule
per day of Super Bio-Curcumin

supplies the equivalent of 2,500-
2,800 mg of commercial curcumin
supplements.
A bottle containing 60
vegetarian capsules of
Super Bio-Curcumin

retails for $38. If a mem-
ber buys four bottles,
the price is reduced to
only $26.25 per bottle.
Contains rice.
References
1. Int J Pharmacol. 2009;5(6):333-45.
2. J Food Nutr Res. 2009;48(3):148-52.
3. Arch Gerontol Geriatr. 2002;34:37-46.
4. Indian J Pharm Sci. 2008 Jul-Aug;70(4):445-9.
5. Bioavailability study of BCM-95
in rats.
Orcas International Inc. 2006.
CAUTION: Do not take if you have gallbladder problems or
gallstones. If you are taking anti-coagulant or anti-platelet
medications, or have a bleeding disorder, consult your
healthcare provider before taking this product.
Bio-Curcumin
and BCM-95
are registered trademarks of

Dolcas-Biotech, LLC.
U.S. Patent Nos. 7,883,728, 7,736,679 and 7,879,373.
Item # 00407
ARE YOU GETTING
Curcumin
s
BENEFITS?
3500
3000
2500
2000
1500
1000
500
0
Curcumin
Standalone Extract
Super Bio-Curcumin
(BCM-95
)
C
u
r
c
u
m
i
n

A
b
s
o
r
b
e
d

b
y

t
h
e

B
o
d
y
(
A
U
C
:

n
g
/
m
L

x

h
)
Absorption of Super Bio-Curcumin
in Humans
Compared with Conventional Curcumin
4
Chart 2. Super Bio-Curcumin
(BCM-95
) showed
6.9 times greater bioavailability (absorption and
sustainability over 8 hours) in humans compared with
conventional curcumin (as measured by the area under
the curve [AUC] in a plot of blood levels against time,
that is, the total amount of curcumin absorbed by the
body over 8 hours).
250
200
150
100
50
0
Curcumin
Standalone Extract
Super Bio-Curcumin
(BCM-95
)
P
l
a
s
m
a

C
u
r
c
u
m
i
n

C
o
n
c
e
n
t
r
a
t
i
o
n

(
n
g
/
m
L
)
in Rats
Compared with Conventional Curcumin
5
Chart 3. Bioavailability in rats fed with BCM-95

is 7.8 times higher than conventional curcumin.
4000
3500
3000
2500
2000
1500
1000
500
0
Plant-Bound Curcumin
with Piperine
Super Bio-Curcumin
(BCM-95
)
C
u
r
c
u
m
i
n

A
b
s
o
r
b
e
d

b
y

t
h
e

B
o
d
y
(
A
U
C
:

n
g
/
m
L

x

h
)
in Humans
Compared with Plant-Bound Curcumin with Piperine
4
Chart 1. Super Bio-Curcumin
(BCM-95
) showed 6.3
times greater bioavailability (absorption and sustain-
ability over 8 hours) in humans compared with plant-
bound curcumin with piperine (as measured by the area
under the curve [AUC] in a plot of blood levels against
time, that is, the total amount of curcumin absorbed by
the body over 8 hours).
How Much Curcumin
Are You Absorbing?
Item # 00407
To order Super Bio-Curcumin

call 1-800-544-4440
Numerous garlic products can be found in health food
stores. Each garlic manufacturer claims that its products are
of the best quality and provide optimal health benefts.
Garlic supplements, however, are not that simple.
When garlic is aged, its harsh and highly odorous
compounds are converted into more benefcial and much
less odorous compounds. Numerous studies have suggested
that supplementing ones diet with aged garlic extract may be
benefcial. Published data about aged garlic extract shows that it:
1. Helps maintain healthy endothelial function and structure.*
1,2
2. Helps maintain healthy immune function.*
3,4

3. Helps maintain healthy cellular DNA structure.*
5,6
Why Life Extension Recommends
Kyolic Aged Garlic Extract
The Life Extension Foundation recommends dietary supplements
based on the published, peer-reviewed scientifc literature. There are more
published studies substantiating the multiple benefts of Kyolic Aged
Garlic Extract than any other brand.
While some other garlic preparations may work as well as Kyolic, we
do not want our members risking their precious health on a supplement that
has not been specifcally documented to work. We therefore recommend
Kyolic over all other brands.
Easy-To-Swallow Kyolic Garlic Capsules
When Kyolic introduced a high-potency tablet two years ago, we at
Life Extension were very pleased. Previous Kyolic supplements required
many capsules to be swallowed to obtain a sufcient quantity of aged
garlic extract powder.
Some people have encountered difculty in swallowing the large Kyolic
tablets. The good news is that Kyolic has a higher-potency capsule available.
Each one of these easy-to-swallow capsules provides 600-mg
of standardized aged garlic extract. The suggested dose for healthy
people is two capsules per day with meals.
The retail price for a bottle containing 120 600-mg capsules of Kyolic
Reserve is $27.95. If a member buys four bottles, the price is reduced to only
$18.75 per bottle.
WHAT IS THE IDEAL
GARLIC
SUPPLEMENT?
Item # 00789
References
1. Planta Med. 1989 Dec;55(6):506-8.
2. Zasshi. 1997 Oct;110 Suppl 1:138P-41P.
3. Cancer Immunol Immunother. 1993
Oct;37(5):316-22.
4. Mol Biother. 1991 Jun;3(2):103-7.
5. Carcinogenesis. 1993 Aug;14(8):1627-31.
6. Carcinogenesis. 1992 Oct;13(10):1847-51.
To order Kyolic Reserve 600-mg capsules,
Remarkable Weight Reduction with
CoffeeGenic

Green Coffee Bean Extract (GCA
)
In a placebo-controlled, human study, subjects
took 350 mg of green cofee extract three times daily
(before meals).
Study subjects were not asked to change their
calorie intake or exercise level, but people participating
in weight loss trials often do make lifestyle changes in
order to increase their odds of shedding body fat.
The impressive fndings, published in January 2012,
noted that men and women lost an average of 17.6
poundsover 10% of body weightafter 12 weeks of
green cofee extract supplementation! There was also
an average 4.44% reduction in body fat percentage!
1
The conclusion is that green cofee extract supports
the ability to lose weight.
1
The form of green cofee
bean extract used in this successful weight loss study
is CofeeGenic Green Cofee Extract (GCA).
How CofeeGenic Works
The active ingredient in green cofee bean extract
is chlorogenic acid.
Published studies on chlorogenic acid demonstrate
a wide range of supportive properties related to insulin
sensitivity
2
and to glucose formation
3,4
and absorption.
5

Clinical research has shown that chlorogenic acid
helps limit after-meal glucose surges, supporting
healthy blood sugar levels for those already within the
normal range.
6
CofeeGenic Green Cofee Extract (GCA).
provides a standardized dose of chlorogenic acid
extracted from green cofee beans.
Comprehensive Formula
The standardized green cofee extract in the
CofeeGenic Weight Management with Green
Cofee Extract (GCA) formula has been enhanced
with the following nutrients to reinforce the ability
to support weight-loss:
1. Green Tea Decafeinated Extract
Green tea contains health-promoting polyphenols,
including epigallocatechin-3-gallate (EGCG).
7
A
number of studies suggest it helps support healthy
metabolic rate and weight loss.
8-13
2. Iodine
This trace element is involved in the production of
thyroid hormones that regulate the basal metabolic
ratewhich afects the bodys rate of calorie burn.
14
3. Chromium
Chromium plays an important role in glucose utili-
zation and is required for the release of energy from
glucose. It is now generally recognized as helping
maintain healthy blood sugar levels for those already
in the normal range.
15-17
4. Integra-Lean African Mango IGOB-131
Fat cells secrete leptin, a hormone that signals
our brain that weve eaten enough.
18
But some
individuals have become resistant to leptin, resulting
in added pounds. An extract from an African mango
called Irvingia gabonensis has been shown to
support leptin sensitivityfollowed by weight loss
and a slimming of the waistline.
19,20
African mango
also helps the body control the rate of carbohydrate
absorption from the intestines, and therefore, the
caloric impact of starchy and sugary foods. And this
extract supports healthy levels of adiponectin, a
hormone that regulates metabolism of lipids and
glucose. Research indicates it has the ability to
promote weight loss.
20
Based on the latest research, CofeeGenic
Weight Management with Green Cofee
Extract (GCA) provides in each capsule:
CofeeGenic Green Cofee Bean Extract 350 mg
[Standardized to 50% chlorogenic acid]
Integra-Lean African Mango 100 mg
(Irvingia gabonensis) proprietary extract (seed)
Chromium 150 mcg
[as Crominex 3+ chromium stabilized with Capros
(Phyllanthus emblica) extract (fruit) and PrimaVie Shilajit]
Iodine (as potassium iodide) 100 mcg
Green Tea decafeinated extract 50 mg
[ 98% polyphenols, 45% EGCG)]
The suggested dose is just one
capsule before each meal.
A bottle of 90 vegetarian
capsules of CofeeGenic Weight
Management with Green Cofee
Extract (GCA) retails for $48.
If a member buys four bottles, the
price is reduced to $31.50 per
bottle.
References
1. Diabetes Metab Syndr Obes. 2012;5:21-7.
2. J Nutr Biochem. 2006 Jan;17(1):63-71.
3. J Agric Food Chem. 2010 Apr 14;58(7):4141-4.
4. Ethnopharmacol. 2010 Jul 6;130(1):93-7.
5. J Nutr Sci Vitaminol (Tokyo). 2007
Apr;53(2):166-73.
6. Nagendran MV. Efect of Green Cofee Bean
Extract (GCE), High in Chlorogenic Acids, on
Glucose Metabolism. Poster presentation
number: 45-LB-P. Obesity 2011,
the 29th Annual Scientifc Meeting of the
Obesity Society. Orlando, Florida. October
1-5, 2011.
7. J Environ Pathol Toxicol Oncol. 1999;18(3):
147-58.
8. Int J Vitam Nutr Res. 2008 Dec;78(6):275-81.
9. Obesity. 2007 Jun;15(6):1473-83.
10. In Vivo. 2004 Jan-Feb;18(1):55-62.
11. Br J Nutr. 2005 Sep;94(3):432-6.
12. Obesity. 2009 Feb;17(2):310-7.
13. J Nutr Biochem. 2011 Jan;22(1):1-7.
14. Available at: http://ods.od.nih.gov/fact-
sheets/Iodine-HealthProfessional/.
Accessed September 24, 2012.
15. Altern Med Rev. 2002 Jun;7(3):218-35.
16. Saudi Med J. 2000 Jan;21(1):45-50.
17. Endocr Pract. 2012 May-Jun;18(3):394-8.
18. Prog Histochem Cytochem. 2010
Sep;45(3):143-200.
19. Lipids Health Dis. 2008 Nov 13;7:44.
20. Lipids Health Dis. 2009 Mar 2;8:7.
Item # 01707
To order CofeeGenic Weight Management
with Green Cofee Extract (GCA),

Caution: This product may lower blood glucose; consult your
healthcare provider before taking this product if you are taking
blood glucose-lowering medication.
This supplement should be taken in conjunction with
a healthy diet and regular exercise program. Results
may vary.
Integra-Lean
Irvingia is protected by U.S. Patent No. 7,537,790.

Other patents pending.
IGOB-131
proprietary extract is a registered trademark of

Gateway Health Alliances, Inc.
CofeeGenic contains GCA which is a registered trademark of
Applied Food Sciences, Inc.
ASTA-
XANTHIN
Provides
Broad Spectrum
Protection
Researchers in Japan have long looked to the sea for sources
of new medications. A big focus has been on astaxanthin found
in microalgae.
1,2

Astaxanthin functions as a natural sunscreen for marine plants.
3

Because astaxanthin is so effective at absorbing solar radiation,

investigators first proposed it would make an effective topical sun-
screen.
1-4
But as researchers looked closer, they discovered that
astaxanthin shields other areas against destructive free radicals.
4,5

Almost every cell in the body, including the eyes, brain, heart,
and kidney, can benefit from astaxanthin.
1,6,7
Recent laboratory
studies show that astaxanthin can even increase life span!
8,9

The discovery of a new way to boost astaxanthin absorption by
12-fold means more of this broad-spectrum nutrient is available
to your entire body. >
BY LIAM HAWKINS
A
S
T
A
X
A
N
T
H
I
N
Astaxanthin is a red pigment molecule that is a member of the carotenoid family
found in certain marine algae. When eaten by shrimp and crustaceans, the pigment
lends its reddish hue to their shells.
10
As astaxanthin makes its way up the food chain,
the color becomes still more concentrated, creating the beautiful reds and pinks we see
in sh such as salmon and in marine birds like amingos.
6,10
Researchers have sought to explore the use of astaxanthin as a topical sunscreen
because of its powerful ultraviolet light-absorbing properties.
5
They soon found, how-
ever, that astaxanthin has many additional benets, including free radical scavenging,
mitochondrial protection, anti-inammatory effects, and protection from glycation.
11-18

ASTAXANTHIN PROVIDES BROAD SPECTRUM PROTECTION
Human studies demonstrate that 6 mg/day of
astaxanthin for 6-8 weeks reduces crows feet wrinkles,
water loss, and age spot size while enhancing mois-
ture content, elasticity, and skin texture in both men
and women, particularly when combined with topical
astaxanthin application.
23
Boosting Immune Function
Your immune system protects you from infections
and routinely patrols your body for emerging can-
cer cells, but when it is over-activated, it can trigger
allergic responses such as asthma and autoimmune
diseases. Studies demonstrate that astaxanthin helps
balance the immune system by stimulating its infec-
tion- and cancer-ghting componentswhile also
helping suppress the overactive immune responses
that create needless inammation.
26

Astaxanthin increases the numbers and activity
of white blood cells called lymphocytes and natural
killer cells that are responsible for creating the bodys
innate immune response to invaders.
27-29
In a mouse
model of breast cancer, astaxanthin-treated animals
showed higher levels of cancer-killing cells and protec-
tive interferon, resulting in delayed tumor growth.
27
Astaxanthin has similar immune-boosting effects
in humans, improving the ability of protective white
blood cells to surround and destroy infecting organ-
isms, especially fungi such as Candida albicans.
30

Astaxanthin also protects human lymphocytes and
neutrophils against the oxidant stresses imposed
by the actions of certain white blood cells without
reducing the killing effects of white blood cells them-
selves.
30,31

Human studies reveal astaxanthins benecial
actions on the over-activated immune system in
patients with allergies and asthma. When astaxan-
In the words of one researcher, astaxanthin shows
demonstrable promise for slowing age-related func-
tional decline.
19
Though the work is only in its infancy, astaxan-
thin has already been shown to extend the life span
of the simple worm called C. elegans.
8,9
Extending life
in primitive organisms like C. elegans is an important
rst test of compounds with the potential for increas-
ing longevity in humans.
Lets examine some of the more compelling lit-
erature on astaxanthin, highlighting its vast ability
to protect and promote healthy immune functioning,
reduce cancer risk, mitigate the impact of diabesity,
protect heart muscle and blood vessels, slow brain
aging, and support eye health.
Astaxanthin: Potent Skin Protection
from the Inside Out
Recent studies show that astaxanthin can rejuve-
native skin from within.
4,11,20
Astaxanthin is among the
most powerful and versatile marine plant antioxidants
known, and as such, it has the ability to scavenge skin-
damaging free radicals.
4,19,21
Even though astaxanthin
is widely distributed through most organs in the body,
it accumulates in the skin, where it makes its way into
all skin layers (topical sunscreens can reach only the
outermost layers).
22,23
This can provide potent protec-
tion against ultraviolet radiation, the most powerful
environmental risk factor for skin cancer.
4
Skin cells that are exposed to ultraviolet light pro-
duce bursts of free radicals that trigger aging effects
such as skin sagging and wrinkles, and promotes
cancer.
4,24
When astaxanthin is applied to skin cells
in culture, it prevents all of those ultraviolet-induced
destructive effects, suggesting that it should signi-
cantly prevent ultraviolet-induced skin aging.
4,24,25
thin (along with ginkgo extract) was applied to white
blood cells from asthmatic patients, it suppressed
reactive cell activation as well as or better than the
antihistamine drugs cetirizine (Zyrtec
) and azelastin
(Astelin
).
32
A subsequent study showed that com-
bining these compounds with the drugs resulted in
improved antihistamine activity.
33
Preventing Cancer at Every Stage
Epidemiological studies reveal that dietary intake
of astaxanthin along with other carotenoids is associ-
ated with the reduced risk of many different types of
cancer. Increased intake of carotenoids such as astax-
anthin typically lowers cancer risk.
34
Unlike many pharmaceuticals, astaxanthin shows
benecial effects against cancer at each stage of its
development.
1. It prevents cancer initiation by protecting
DNA from ultraviolet and oxidant damage.
4,35
2. It promotes early detection and destruction
of cells that have undergone malignant trans-
formation by boosting immune surveillance.
7
3. It prevents cancerous growth in cells that
evade immune detection by reducing inam-
matory changes such as those that appear in
aging.
12,36
4. It blocks the rapid cell replication of tumors
in their growth phase by stopping the cancer
cell reproductive cycle and restoring cancer
cells ability to die off by apoptosis.
37-40
5. It prevents tumors from spreading by
reducing tumor production of tissue-melting
proteins.
36
Animal studies show that these properties of astax-
anthin contribute to a reduced number of precancer-
ous lesions in the colon, and to fewer and smaller
tumors when they do develop in the colon and
breast.
27,41
Reducing Diabesity and Its Consequences
Diabetes and obesity are so closely intertwined that
scientists now speak of them together as one entity,
diabesity. Diabesity is a major component of meta-
bolic syndrome. Astaxanthin holds multiple benets
in managing diabesity, with its resulting oxidant stress,
high levels of chronic inammation, and extensive
tissue damage from protein and lipid glycation.
42
What You Need to Know
Diverse Health Benefits
of Astaxanthin
Japanese scientists developed astaxanthin

from marine algae as a potent oral agent to
protect against ultraviolet damage to skin.
Other appealing properties of astaxanthin

have since emerged, supporting its role
as an antiaging supplement that protects
organs throughout the body from the ravages
of oxidant stress, inflammation, glycation, and
mitochondrial dysfunction.
Astaxanthin promotes healthy immunity and

suppresses inflammation, especially in aller-
gies and asthma, while protecting tissues
from the impact of obesity and diabetes,
shielding blood vessel cells from damage,
preventing changes that lead to cancer,
slowing cognitive decline, and preserving
vital eye functions.
Lab studies reveal that when obese and/or diabetic
animals are supplemented with astaxanthin, they
experience lower blood glucose levels, improved insu-
lin sensitivity, and reduced inammation and oxida-
tive stress.
42-45
In addition, astaxanthin preserved the
ability of the pancreas to secrete insulin.
42

Astaxanthin supplementation also prevents mas-
sive body weight gain in animals fed high-fat or high-
fructose diets.
45,46
Obese animals, like obese humans,
develop dangerous fat accumulations in their liv-
ers, predisposing them to cirrhosis and liver cancer.
Astaxanthin supplements have been found to reduce
liver fats and triglyceride levels.
46
In overweight and
obese humans, astaxanthin suppresses dangerous
lipid peroxidation and stimulates healthy natural anti-
oxidant defenses in the body.
47
In addition to preventing the main elements of
diabesity, astaxanthin helps alleviate the long-term
consequences faced by diabetics. Studies show that
astaxanthin supplementation slows the development
of diabetic nephropathy (kidney disease),
43,48
reduces
cataract formation and diabetic retinopathy (both
preventable forms of blindness in diabetics),
49,50
and
reduces the many cardiovascular complications of
diabesity.
51
Protecting Cardiovascular Health
Astaxanthin has powerful antioxidant effects that
ght cardiovascular diseases at multiple levels. In
hypertensive rats, astaxanthin lowers blood pressure,
improves endothelial function, and delays hyper-
Much as we shun them in our diets, fat molecules
are essential to human life and function. But the fats
that form our cell membranes are a special kind of
molecule called phospholipids. Phospholipid mol-
ecules have electrically charged heads that mix well
with the water inside and outside cells, and neutral
tails that mix with fats to form cell membranes.
These properties make phospholipids ideal as
emulsifiers, agents that help oil molecules mix with
water. Carotenoids like astaxanthin are mostly oil-
soluble and therefore mix poorly with water, limiting
their bioavailability. By emulsifying such molecules,
however, phospholipids have been shown to enhance
absorption by nearly 12-fold, compared with a stan-
dard commercial formula lacking phospholipids.
74
Emulsification of fat-soluble molecules like
astaxanthin is just one of the unique properties of
phospholipids. These versatile molecules give cell
membranes, particularly those of brain and nerve
cells, their special characteristics, which include
the ability to modulate inflammation.
75,76
A molecule
called phosphatidylcholine is the most abundant
phospholipid in such cells.
77
Our bodies can make some phosphatidylcholine,
but still require outside sources (such as choline)
to maintain supplies. Phospholipids, like all fats, are
extremely prone to oxidation (thats why butter and
oil go rancid). Studies show that astaxanthin incorpo-
rates itself perfectly into and across the fat-laden cell
membrane, where it acts as a powerful inhibitor of
lipid oxidation.
78-80
You need phosphatidylcholine to protect nerve
cell function, and you need astaxanthin to protect
phosphatidylcholine from destructive oxidation. As an
added bonus, phosphatidylcholine helps with intesti-
nal absorption of supplemental carotenoids.
To ensure optimal assimilation, take astaxanthin
supplements with the meal that contains the most fat.
How to Enhance the Bioavailability of Astaxanthin
tension-induced strokes.
52-54
In humans and animals,
astaxanthin helps normalize lipid proles, reducing
triglyceride and cholesterol levels while boosting ben-
ecial HDL-cholesterol.
55,56
These effects reduce the
risk of a clot forming within a major vessel.
Astaxanthin also reduces inflammation and
reduces the production of certain enzymes that desta-
bilize plaques and make them vulnerable to rupture
and that block blood ow.
57
In the heart muscle itself, astaxanthin boosts mito-
chondrial energy delivery, which helps the heart mus-
cle contract more powerfully and efciently.
58
This
is especially valuable in the event of a heart attack
because it helps surviving muscle to rapidly take over
from damaged areas.
People with cardiovascular disease are at risk for
vascular dementia, a form of cognitive decline caused
by decreased brain blood ow and damage to cere-
bral vessels. Astaxanthin supplements in such animals
reduce the rate of complications such as strokes, and
improve cognitive performance, allowing the animals
to live more vigorous and active lives.
52
Slowing Brain Aging
Astaxanthin exerts multiple benecial effects in
the brain.
59
Unlike many other antioxidant molecules,
astaxanthin crosses the blood-brain barrier, allowing
it to saturate and protect brain tissue.
14
These features
have led experts to label astaxanthin a natural brain
food.
14
In animal models, astaxanthin has been found to
reduce the risk of stroke, diminish the size of stroke
areas in the brain, and improve motor activity fol-
lowing a stroke.
60-62
One study, in fact, demonstrated
that pre-treatment with astaxanthin completely pre-
vented ischemic brain injury following 2 hours of
blockage of one of the brains largest arteries.
62
Astaxanthin also directly combats the oxidative
impact of abnormal proteins in both Alzheimers
and Parkinsons diseases.
59,63,64
Studies show that
beta-amyloid, the toxic protein found in the brains
of Alzheimers patients, is also found on red blood
cells, where it reduces oxygen delivery to tissues.
65
Supplementation with astaxanthin has been found
to decrease the accumulation of amyloid-beta on red
blood cells.
66
A human study has determined that doses of
astaxanthin as high as 20 mg once daily for 4 weeks
are free of side effects and suggested that the supple-
ment was effective for age-related decline in cogni-
tive and psychomotor functions.
67
And 12 mg/day
astaxanthin improved cognitive health scores and
learning scores in a study of healthy middle-aged
and elderly subjects with age-related forgetfulness.
68
Important Promoter of Eye Health
Age- and diabetes-related eye diseases contribute
to visual impairments and blindness in millions of
Americans. Astaxanthin has been found to prevent
or slow three of the most common eye diseases: age-
related macular degeneration, cataracts, and glaucoma.
The human retina naturally contains the carot-
enoids lutein and zeaxanthin, molecules closely related
to astaxanthin. Supplementation with all three carot-
enoids (astaxanthin 4 mg/day, lutein 10 mg/day, zea-
xanthin 1 mg/day) has been shown to improve visual
acuity and contrast detection in people with early age-
related macular degeneration.
69
In laboratory studies,
astaxanthin supplementation protects retinal cells
against oxidative stress and signicantly reduces the
area of destructive new blood vessel growth on retinas,
a hallmark of advanced macular degeneration.
70,71
Studies of patients with age-related macular degen-
eration reveal signicant improvements in retinal
electrical outputs following supplementation with
astaxanthin and other carotenoids.
72
Glaucoma, an increase in the pressure of uid
inside the eyeball, eventually results in retinal cell
death from oxidant damage and loss of blood ow.
Astaxanthin restores retinal parameters to normal in
eyes with experimentally-induced glaucoma.
73
Summary
Astaxanthin, a red pigment that originates in
marine algae, is one of natures most potent anti-
oxidants. It has numerous other useful properties as
well: it is an efcient blocker of ultraviolet radiation,
it reduces the impact of glycation, and it decreases
inammatory responses.
Studies are revealing astaxanthins remarkable
ability to ght the prime causes of aging, not only in
the skin, where it was rst studied, but in organs and
tissues throughout the body. Astaxanthin protects and
promotes healthy immune functioning, reduces can-
cer risks, mitigates the impact of diabesity, protects
heart muscle and blood vessels, slows brain aging, and
supports eye health.
These multiple benets of astaxanthin, coupled
with its proven safety record, make it a vital compo-
nent of a responsible program of nutritional supple-
mentation.
If you have any questions on the scientific content

of this article, please call a Life Extension
Health Advisor at 1-866-864-3027.
References
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79. Goto S, Kogure K, Abe K, et al. Efcient radical trapping at the
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thin. Biochim Biophys Acta. 2001 Jun 6;1512(2):251-8.
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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
CAUTION: Take at least two hours apart from
medications. Because this product may lower blood
glucose, consult your healthcare provider before taking
this product if you are taking blood glucose-lowering
medication. Taking fber products without adequate
liquid may increase the risk of choking. Consult your
healthcare provider before taking this product if you
have difculty swallowing or esophageal narrowing.
Integra-Lean Irvingia is protected by U.S. Patent
No. 7,537,790. Other patents pending. Phase 2
is used under license. LuraLean is a registered
trademark of AHD International LLC.
CofeeGenic contains GCA which is registered
trademark of Applied Food Sciences, Inc.
References
1. Lancet. 2011 Aug 27;378(9793):826-37.
2. Lipids Health Dis. 2009 Mar 2;8:7.
4. Altern Ther Health Med. 2007 Jul-Aug;13(4):32-7.
5. J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):166-73.
6. Nagendran MV. Efect of Green Cofee Bean Extract
(GCE), High in Chlorogenic Acids, on Glucose Metabo-
lism. Poster presentation number: 45-LB-P. Obesity
2011, the 29th Annual Scientifc Meeting of the
Obesity Society. Orlando, Florida. October 1-5, 2011.
7. Diabetes Metab Syndr Obes. 2012;5:21-7.
Importance of Taking Calorie Control Weight
Management Formula Before Heavy Meals
Once we accept the fact that weight loss requires more
than diet and exercise alone, it becomes easy to understand
the importance of taking the Calorie Control Weight
Management formula before two heaviest meals of the day
to help neutralize the unwanted efects of caloric excess.
Those seeking to emulate the dose used in the 2012 study
that induced an average 17.6 pounds of weight loss
7
might
want to also take a 200 mg capsule of standardized green
cofee bean extract along with a serving of Calorie Control
Weight Management Formula with CofeeGenic Green
Cofee Extract (GCA) before meals.
Each appetizing blueberry favored stick pack or scoop of the Calorie
Control Weight Management Formula with CofeeGenic Green Cofee Extract,
powder provides:
CofeeGenic Green Cofee (Cofea arabica) extract (bean) 200 mg
[std to 50% Chlorogenic acid (100 mg)]
LuraLean propolmannan 2,000 mg
(Amorphophallus konjac K. Koch, ssp. Amorphophallus japonica) fber extract (root)
Phase 2 Phaseolus vulgaris white kidney (bean) extract 445 mg
Integra-Lean African Mango (Irvingia gabonensis) 150 mg
proprietary extract (seed)
Tea Slender Green Tea Phytosome 150 mg
Green Tea (Camellia sinensis) Phytosome decafeinated extract
(leaf ) bound to phosphatidylcholine (from lecithin)

Calorie Control Weight Management
Formula with CoffeeGenic

Green
Coffee Extract (GCA") Item # 01693*
(Each serving contains approximately 6 mg cafeine)
A bottle containing 60 servings of Calorie
Control Weight Management Formula with
CofeeGenic

Green Cofee Extract (GCA)
natural blueberry favor powder retails for $60.
If a member buys four jars, the price is reduced
to just $40.50 per jar.
For added convenience of use, this new
formula also comes in 60 individual stick
packs. Each box containing 60 servings
of Calorie Control Weight Management
Formula with CofeeGenic

Green Cofee
Extract (GCA) natural blueberry favor
powder retails for $64. If a member buys
four boxes, the price is reduced to just $45
per box. Item # 01694*
Contains soybeans. Contains corn.
Item # 01693
Item # 01694
*These supplements should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
CALORIE CONTROL WEIGHT MANAGEMENT FORMULA
Now with CoffeeGenic Green Coffee Bean Extract (GCA)
To order any of the
Calorie Control Weight Management Formulas with
CoffeeGenic Green Coffee Extract (GCA), call 1-800-
544-4440 or visit www.LifeExtension.com
Nearly 80% of highly motivated people fail to achieve
long-lasting weight loss with diet and lifestyle modifca-
tions alone.
1
Thats why the Calorie Control Weight Management
Formula was designed. Clinical studies validate that when
overweight humans take just some of the natural ingre-
dients in this formula combined with reduced calorie
intake, there is a greater loss of body fat compared to diet
alone.
2-4
Calorie Control Weight Management Formula
with CofeeGenic Green Cofee Extract (GCA) can
help give you the winning edge when following a calorie-
modulated weight loss program.
Calorie Control Weight Management Formula comes
in a natural blueberry favor and is available in a 60-serv-
ing bottle or individual stick packs that you can conve-
niently use when away from home.
Each dose has been fortifed with 200 mg of Cofee-
Genic Green Cofee Extract (GCA) to impede rapid
absorption of starches and sugary foods
5
and suppress
after-meal glucose surges.
6
Each bottle of Super K lasts 90 days, so members
pay as little as $6.75 a month for this high-potency
blend of all three active forms of vitamin K. The retail
price for a bottle containing 90 softgels is $30. If a
member buys four bottles, the price is reduced to
$20.25 per bottle.

(The same Super K formula consisting of Vitamin K1, K2 (MK-4)
and K2 (MK-7) can be found in the Life Extension
Super Booster.
If you take the Super Booster, you do not need additional Super K with
Advanced K2 Complex softgels.)

Warning to Coumadin
(warfarin) Drug Users

Patients prescribed vitamin K-antagonist anti-coagulant prescription drugs like warfarin should consult their physician before taking
vitamin K supplements like Super K and Super Booster. There is evidence, however, that users of drugs like warfarin could benet
from a consistent low dose of supplemental vitamin K. Ask your doctor if you can take a low dose (45 mcg a day) of vitamin K2 in
the long-acting MK-7 form for the purpose of stabilizing your INR levels and also protecting your body against long-term vitamin K
decit. Do not initiate any form of vitamin K supplementation without full cooperation of your treating doctor, as your doctor may
need to increase your dose of warfarin to compensate for the vitamin K you supplement with. Life Extension provides several forms
of low-dose vitamin K for physician consideration.
There are three forms of vitamin K that the human
body can utilize to promote arterial health and bone
support.
1-8
Life Extension
s Super K with Advanced K2

Complex provides the dynamic trio of vitamin K forms
in one softgel, including vitamin K1, vitamin K2
(MK-4), and vitamin K2 (MK-7).
VITAMIN K1 is the form of vitamin K that is found
in green vegetables. K1 is tightly bound to plant ber,
so only a fraction is absorbed into the bloodstream.
Supplementation ensures ample K1 blood levels.
VITAMIN K2 is usually found in meats, dairy, and
egg yolks. Since you may be avoiding these foods for
health reasons, ingesting a K2 supplement is essential.
MK-4 is the most rapidly absorbed form of K2, and
MK-7 boasts a very long half-life in the body, making
both forms the perfect complement to any vitamin K
regimen.
9
Super K formula provides in just one daily softgel:

Vitamin K2 (MK-7) 200 mcg
Vitamin K2 (MK-4) 1000 mcg
Vitamin K1 1000 mcg
j t d iil ft l
I
t
e
m

#

0
1
7
2
4
To order
Super K with Advanced K2 Complex
or Super Booster, call 1-800-544-4440 or
References
1. Vitam Horm. 2008;78:393-416.
2. Nutrition. 2006 Jul-Aug;22(7-8):845-52.
3. Calcif Tissue Int. 1996 Nov;59(5):352-6.
4. Z Kardiol. 2001;90 Suppl 3:57-63.
5. Atherosclerosis. 2008 Jul 19.
6. J Bone Miner Metab. 2008;26(3):260-4.
7. Am J Clin Nutr. 2008 Apr;87(4):985-92.
8. J Biol Regul Homeost Agents. 2008
Jan-Mar;22(1):35-44.
9. Blood. 2007 Apr 15;109(8):3279-83.
COMPREHENSIVE VITAMIN K
FORMULA
A bottle of 30 softgels
of Astaxanthin with
Phospholipids retails
for $16. If a member
buys four bottles, the
price is reduced to
$10.50 per bottle.
References
1. Mol Nutr Food Res. 2012
Sep;56(9):1385-97.
2. Eur J Pharm Sci. 2003 Jul;
19(4):299-304.
Astaxanthin is a fat-soluble compound. The
challenge to deriving maximum benefts is its
normally limited absorptionas low as about
50%.
1,2
Assimilation of astaxanthin is impeded by
limited uptake and intestinal degradation.
A new Astaxanthin with Phospholipids
combines 4 milligrams of natural astaxanthin
with a proprietary blend of phospholipids.
By incorporating phospholipids, scientifc
study shows that absorption may be enhanced
several-fold.
2

The new Astaxanthin with Phospholipids
uses four diferent phospholipids to facilitate
maximum absorption of astaxanthin into the
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E
As we age, one of our priorities is maintaining
optimal glucose levels to avoid heart disease,
cancer, and diabetes.
1-5

Fortunately, many Life Extension
members
use supplements, hormones, and drugs to improve
their insulin sensitivity, which facilitates the more
efficient removal of glucose from the blood.
6-12
Less well-known, however, is the fact that there
are certain foods proven to decrease blood sugar
levels!
7,13-16
Specifically, barley and black beans
have been extensively studied for their ability to
maintain glycemic control.
In this article, you will learn how these two foods
have been shown to lower blood sugar and inhibit
diabetes and other glycemic-stress-related prob-
lems such as cardiovascular disease and obesity.
Including these two glucose-lowering foods as
part of your normal diet can help maintain better
blood sugar levels. >
Foods That
Safely Reduce
BLOOD
GLUCOSE
BY MICHAEL DOWNEY
Barley Lowers Blood Sugar
and Insulin Levels
Excessive dietary carbohydrates, such
as white rice and potatoes, trigger surges
in blood glucose, a key factor in the world-
wide epidemic of type II diabetes.
17,18
Aging
increases this effectbeginning as early as
age 20.
17
National Institutes of Health data indi-
cate that 35% of Americans aged 20 or
older have abnormally high blood glucose
levelsknown as prediabetesas do 50%
of those aged 65 years or older!
17
Fortunately, research has established
that consumption of insoluble dietary
berwhich is found in certain whole
grains, including barley
19
is associated
with a reduced risk of type II diabetes.
20
Barley is also a rich source of soluble
ber.
19
In fact, one study conducted on over-
weight women found signicantly lower
insulin and glucose responses following
barley ingestion, compared to ingestion of
oats.
15
The researchers concluded that par-
ticle sizeour versus akesmade little
difference. The reduced glucose effect was
determined to be the result of the higher
content of the soluble ber in the barley.
15
FOODS THAT SAFELY REDUCE BLOOD GLUCOSE
Barley Effects Beyond Blood Sugar
Barley improves risk factors for cardiovascular
disease and stroke.
Barley ber increases the excretion of bile acids
into the intestines. Since these acids are comprised
of oxidized cholesterol, this lowers total serum cho-
lesterol.
29
Studies have conrmed that barley lowers
cholesterol,
30
low-density lipoprotein (LDL),
31,32
and
blood pressure.
33
Barley is a rich source of soluble and insoluble
berboth of which benet gastrointestinal health.
The soluble ber in barley binds with water, add-
ing bulk to stools and promoting regular bowel
movements.
34
Some of the insoluble ber in barley is
digested by colonic bacteria to produce short-chain
fatty acids, which may promote bowel health
35
and
accelerate repair of colonic mucosa in those with
ulcerative colitis.
35
Like other ber-rich foods, barley is associated
with weight control.
Some trials have suggested that greater dietary ber
consumption increases satiety and decreases caloric
intake.
36-38
A diet high in protein and berboth found
in barleyhas been shown to minimize overall daily
calorie ingestion.
39,40
Another study found that, by suppressing free fatty
acid levels in the blood, whole barley regulates blood
sugar better than other grainsand for up to 10
hours after consumption!
21
Our bodies cannot digest the viscous soluble ber
in barley, which binds with water to slow food passage
through the digestive system. This tempers the bodys
glucose and insulin responses after a meal.
22,23
Substantial research has demonstrated that the
soluble ber in barley lowers postprandial glucose and
insulin.
15,23-27
This has been demonstrated not only in
the more common single-meal test studies of limited
duration, but also in a 12-week study that pinpointed
the longer-term effects of barley consumption on non-
diabetic individuals on a weight-neutral diet.
28
This prospective, randomized, placebo controlled,
double blind trial evaluated 50 healthy subjects with-
out prior diagnosis of diabetes. After 12 weeks, the
scientists found that daily ingestion of soluble barley
ber signicantly reduced fasting serum insulin val-
ues and, during oral glucose tolerance tests, signi-
cantly lowered blood glucose responses.
28
The team concluded that soluble barley ber may
slow the deterioration of insulin sensitivity for indi-
viduals at increased risk for diabetes mellitus.
28
Black Beans Also Target Blood Sugar!
Epidemiological studies showed a strong associa-
tion between increased consumption of the common
bean (Phaseolus vulgaris)which includes black
beans, pintos, and othersand a reduced risk of
chronic diseases, including type II diabetes.
41-44
In 2012, this was conrmed in two separate, ran-
domized trials in which beans were demonstrated
to signicantly lower glycemic response in type II
diabetics.
16,45
Scientists believe that the compounds in beans may
slow activity of the alpha-amylase enzymes that help
break down starch into sugar. This would reduce or
slow sugar release.
Also, beans have a low GI (glycemic index), which
by denition means they produce a relatively low rise
in blood glucose after a meal
46-48
compared to high-
glycemic index items such as white rice, which sharply
elevate postprandial glucose and increase oxidative
stress.
49-51
The glucose-lowering effects of beans consumed
alone has been well documented, although at least
one study had measured this effect when beans
were eaten as part of a meal.
16,41,48,52
However, a large
study recently published in the British Journal of
Nutrition found that beans signicantly reduce glyce-
mic response even when combined with othereven
higher glycemic indexfoods.
41
Also, a review and meta-analysis that examined
41 studies found that bean consumptionalone, or
as part of a low-glycemic index or a high-ber diet
improves markers of longer-term glycemic control
in humans.
46
Specically, this review found that beans produced
improvements in HbA1c (glycated hemoglobin) and
fructosamine (glycated serum protein).
46
Both are
markers for longer-term plasma glucose concentra-
tion. These observed improvements indicate that
beans deliver signicant diabetic control over a pro-
longed period.
46
These ndings clearly demonstrate that aging
individualsboth those with, and those at risk for,
type II diabetescan restore glycemic control with
simple diet changes that increase intake of black
beans and barley.
Black Beans Help Prevent
Devastating DNA Damage
A study was designed to evaluate the toxicogenic
(toxin-producing) versus protective effect of cooked
and dehydrated black beans on bone marrow and
peripheral blood cells of mice.
Reduce Blood Glucose
Aging promotes dangerously increased

levels of blood sugar.
In addition to nutrients, hormones, and

drugs, certain foods improve glycemic
control.
Barley and black beans are both excellent

sources of fiber and can not only minimize
the amount of calories consumed, but
can improve feelings of fullness after
meals as well.
Barley and black beans have been shown

to improve blood glucose and insulin levels.
Research demonstrates that these food

items help prevent diabetes and glycemic-
related disorders such as cardiovascular
disease and obesity.
Black beans
Remarkably, these scientists found
that black beans signicantly reduced
the frequency of genetic damage induced
by chemical mutagens in these types of
cells!
53
Although not originally part of the
study, they also observed that black
beans afforded leukocytes the same pro-
tection against induced DNA damage.
53
Beans Lower Cardiovascular
Disease Risk Factors
Research has shown that beans lower
cholesterol.
44,54-56
This effect is largely
attributed to their high soluble-ber
contenta benet also associated with
other soluble-ber-rich foods.
But beans deliver other cardiovascu-
lar effects that ow from their capacity
to affect blood sugar.
Both elevated after-meal glucose and
chronic hyperglycemia can increase
oxidative stress, worsen endothelium-
dependent vasodilation, and raise blood
pressureall serious factors in cardiovascular dis-
ease.
50,57-59
However, by controlling after-meal glucose
responses and promoting prolonged diabetic control,
beans may help prevent these glucose-related cardio-
vascular risk factors.
16,28,46
In fact, research has now conrmed that low gly-
cemic index foods such as beans are associated with
a lower risk for cardiovascular disease, even after
accounting for known risk factors such as smoking,
diabetes, obesity, and family history of heart dis-
ease.
43-45,60
A High-Bean Diet Improves Biomarkers for
Cancer Risk
Scientists have identied mechanisms by which
increased insulin response raises cancer risk.
61,62

Studies have found that higher bean intake, by
reducing insulin, inammatory markers, and altering
cell signaling pathways, is associated with reduced
cancer risk.
63-65
Beans May Inhibit Obesity
Beyond evidence of decreased calorie ingestion
with increased ber diets,
36-40
observational and con-
trolled studies indicate that consumption of beans
improves short-term satiety and weight loss, when
combined with energy restriction.
66,67
Black Beans Promote Healthy
Gastrointestinal Function
The indigestible fractionwhich is a measure of
the level of indigestibility of a foodin black beans
has been shown to be greater than the indigestible
fraction in some other beans such as lentils and chick-
peas.
68
In fact, the indigestible fraction of black beans
provides colonic bacteria with the perfect mixture of
compounds to generate butyric acid, which is used
by colon-lining cells called colonocytes to fuel their
activity and keep the lower digestive tract functioning
smoothly. It affects cellular proliferation, differentia-
tion and apoptosis (programmed cell death), and has
anti-inammatory effects.
69
Summary
Evidence strongly indicates that barley and black
beans provide superior food options to help reduce
blood sugar levels and offer protection from oxidative
stress and chronic diseases. They can be substituted
for unhealthy foods that have become so prevalent in
Western diets.
If you have any questions on the scientific

content of this article, please call a Life Extension

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2012 Aug 30. doi: 10.1002/jsfa.5852. [Epub ahead of print] Barley
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Keep in mind that you may already be
getting 1,000-3,000 IU of vitamin D in
your multi-nutrient formulas.
A new vitamin D is now available in
superior absorbing softgels. A recent
study demonstrated that the use of one
5,000 IU vitamin D softgel daily resulted
in a near 30% increase in vitamin D levels
in just 60 days.
Life Extension members
are well aware that vegetable
soups sold by processed food
companies are loaded with
high-glycemic carbohydrates
rice, potatoes, or pastaand
inexpensive ingredients such as
corn, sugar, and even omega-6
fats such as cottonseed oil. In
other words, they provide virtu-
ally no health benefts.
Thats why theyve come to
rely on the vegetable soups from
Life Extension that contain
only healthy ingredientsloads
of garden-fresh vegetables,
mushrooms, heart-healthy
extra-virgin olive oil, and a host
of other benefcial plant foods.
These soups are made with no
saturated fat, cholesterol, trans
fat, or dairy.
The newest addition to this
family of nutritionally-rich soups
is Rich Rewards
TM
Black Bean
Vegetable Soup. It delivers the
same healthy vegetable ingredi-
entsbut with the additional
health benefts of black beans
and barley and is an excellent
source of fber.
Black Bean
Vegetable
Soup
Rich Rewards
A New
Low-Glycemic
Healthy Soup
without
High-Glycemic
Carbs Found in
Commercial Soups

FIBER
DAILY
VALUE 52
%
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One Smart Bowl of Soup
Contains about 3.5 servings of black beans,
barley, mushrooms, and vegetables per bottle
Only 180 calories per serving
Very low sodium and low fat
No added starches or sugars!
Excellent source of ber and protein
0g trans fat. No saturated fat or cholesterol
BLACK BEANS AND BARLEY
Extensive documentation demonstrates that
the black beans:
- Slgnlcantly support blood sugar levels that are
already within the normal range
1-3
even over a
prolonged period
4
and even when combined
with higher-glycemic foods.
3
- Provlde slgnlcant support for the DNA integrity
of bone marrow and peripheral blood cells.
5
- Are assoclated wlth support for cardiovascular
health.
1,6-8
- |mprove short-term satlety and weight loss,
when combined with a reduced calorie diet.
9-11

- Promote healthy gastrointestinal function,
12

providing healthy colonic bacteria with the
perfect mixture of compounds to promote the
production of butyric acid, which is used by
colon-lining cells to keep the lower digestive
tract functioning smoothly.
13
Barley scientifcally shown to:

- Support the colonlc fermentatlon of lndlgestlble
or insoluble carbohydrates.
14
- Provlde a rlch source of soluble fber,
15
which
promotes bowel function and metabolic
health.
16,17
- Support blood sugar and insulin levels that are
already in the normal range
18
which it does
better than other grains.
15,18,19
- Help malntaln levels of total cholesterol,
20
LDL
cholesterol,
21,22
and blood pressure
23
already in
the normal range.
- Support weight control through increased
satiety and decreased overall caloric ingestion.
24-26
Sultable for vegans, each servlng of Rich
Rewards
TM
Black Bean Vegetable Soup ofers
impressive nutrition: 52% of your daily fber value,
28% of your daily protein value, and a rich supply
of vegetables, all in just 180 calories.
The entire container supplies about 3.5 serv-
ings. And whlle the PDA says the 8PA llnlng ln most
soup cans is safe, we at Life Extension have always
used 8PA-free contalners.
A -ounce contalner of . servlngs of Rich
Rewards
TM
Black Bean Vegetable Soup retails for
$13. If a member buys 6 containers, the price is
reduced to $9.19 per container.
Nutrition Facts
Serving Size 1 cup (245g)
Servings Per Container about 3.5
Amount Per Serving
Calories 180 Calories from Fat 30
% Daily Value *
Total Fat 3g 5%
Saturated Fat 0g 0%
Trans Fat 0g
Cholesterol 0mg 0%
Sodium 25mg 1%
Total Carbohydrate 25g 8%
Dietary Fiber 13g 52%
Sugars 6g
Protein 14g 28%
vitamin A 40% vitamin C 40%
Calcium 8% lron 25%
*Percent Daily values are based on a 2,000
calorie diet. Your daily values may be higher or
lower depending on your calorie needs:
Calories: 2,000 2,500
Total Fat Less than 65g 80g
Saturated Fat Less than 20g 25g
Cholesterol Less than 300mg 300mg
Sodium Less than 2,400mg 2,400mg
Total Carbohydrate 300g 3?5g
Dietary Fiber 25g 30g
Black Bean
Vegetable Soup
To order Rich Rewards
TM

Black Bean Vegetable Soup, call
1-800-544-4440 or visit
www.LifeExtension.com

References
1. Arch Intern Med. 2012 Oct 22:1-8.
2. J Sci Food Agric. 2012 Aug 30.
3. Nutr J.2012Apr 11;11:23.
4. Diabetologia. 2009;52:1479-95.
5. Food Chem Toxicol. 2003 Dec;41(12):1671-6.
6. Am J Clin Nutr. 2000;72:912-21.
7. Br J Nutr. 2012 Aug;108 Suppl 1:S66-73.
8. PLoS One. 2012;7(12):e52182.
9. Adv Nutr. 2010;1:17-30.
10. Br J Nutr.2011 Jul;106(2):196-202.
11. Appetite. 1988 Feb;10(1):1-11.
12. J Sci Food Agric. 2010 Jul;90(9):1417-22.
13. J Med Microbiol. 2010 Feb;59(Pt 2):141-3.
14. J Gastroenterol Hepatol. 2001 Feb;16(2):160-8.
15. J Am Coll Nutr. 2005 Jun;24(3):182-8.
16. J Am Acad Nurse Pract. 2012 Aug;24(8):476-87.
17. J Nutr Metab. 2012;2012:851362.
18. J Clin Nutr. 2006 Sep;60(9):1092-9.
19. Eur J Nutr. 2008;47(6):294-300.
20. Eur J Clin Nutr.2010 Dec;64(12):1472-80.
21. Ann Fam Med.2009 Mar-Apr;7(2):157-63.
22. Br J Nutr. 2007 Jun;97(6):1162-8.
23. Vasc Health Risk Manag. 2008;4(6):1265-72.
24. Appetite. 2009 Dec;53(3):363-9.
25. Appetite. 2009 Dec;53(3):338-44.
26. J Am Coll Nutr. 2010;29(2):113-21.
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FRAN
DRESCHER:
Defeating Cancer
with Hard Work and Humor
The first thing you recognize about Fran
Drescher, obviously, is her voice. Its as distinct
as your own mothers.
Its the voice that carried her to two Emmy
Award nominations for her work on the hit sit-
com, The Nanny. Its the voice that has been
featured on The Simpsons and Law & Order:
Criminal Intent, but lately, Drescher is putting
her extraordinary vocals to use as an activist
for her anti-cancer group, Cancer Schmancer,
whose mission is to end cancer mortality due
to late stage diagnosis by preventing it from
occurring and catching it early.
For Drescher, the genesis of this project
comes from her personal experience as a uter-
ine cancer survivor who was misdiagnosed and
mistreated by doctors for several years.
It took me two years of seeing doctors to
get a diagnosis after being misdiagnosed for
a peri-menopausal condition I didnt have, she
says. It motivated me to write the book Cancer
Schmancer, which became a New York Times
bestseller because I didnt want what happened
to me to happen to other people. When I went
on my book tour, I realized that what happened
to me actually happens to millions of people!
Missed diagnosis, late diagnosis, its far too
common. Thank God I was only stage one when
I was finally diagnosed.
When Drescher looks back on her early years
as a patient she recognizes that she didnt know
what questions to even ask of her doctors. Being
the comedian that she is, she naturally puts a
comedic spin on the entire experience.
It took me two years and eight doctors before
finally being told I had gynecologic cancer, she
says. I got in the stirrups more times than Roy
Rogers! >
BY JON FINKEL
Formulating a Vision
While Drescher was on her lecture tour for the
book, the personal stories of frustration that people
were telling her about their own cancer experience
caused a light bulb to go off in her head.
I just had a vision that everyone should be diag-
nosed at stage one, Drescher says. I think thats
where our healthcare needs to go. I started creat-
ing the Cancer Schmancer movement as an early
detection organization. The cornerstone of the
movement now involves prevention as well because
I think that the nation is too focused on the cure
without thinking about what the causes are and
eliminating them.
FRAN DRESCHER: DEFEATING CANCER
While many of the items on the ingredient list that
may have toxic properties are said to only be detected
in trace elements, theres really no data on the effect
of assaulting your body every day with your particu-
lar combination of chemicals. Whether your toiletries
contain small amounts of formaldehyde or lead, you
may be putting yourself at risk.
Practical Ways to Eliminate Toxic Exposure
As an example, Drescher talks about the use of alu-
minum in most anti-perspirant deodorants.
Many people that end up with Alzheimers disease,
Parkinsons disease, and other neurological problems
are often found to have high levels of aluminum in their
bodies, she explains. When people use aluminum-
based deodorant, they are sealing up one
of the most effective ways the body has
to detox itself through perspiration. So
not only are you sealing toxins in your
body, youre doing it with a toxin: alu-
minum.
Life Extension
mentioned the can-

cer-causing dangers of cooking at high
heat in a recent issue, but compounding
the problem of cooking at high temper-
atures is the problem of scorching food
in aluminum containers. When you use
aluminum baking pans or aluminum
foil on the barbecue, it makes it easy
for dangerous chemicals that we cant
see or smell to seep into our food.
People really need to educate them-
selves and question everything about
how they prepare their food, Drescher
says. Even our most trusted brands
that we grew up with, that our moth-
ers and grandmothers used, may be
bringing harmful substances into your
house.
In addition to health and beauty
products, Drescher says that dangerous
chemicals are lurking in cleaning prod-
ucts, laundry products, dishwashing
detergent, kitchen cleansers, and even
baby products.
Beyond the Household
Ten years ago, Cancer Schmancer
was just a book; now its a full-edged
movement with Fortune 500 company
afliations and an advisory board that
includes doctors from such prestigious
To that end, the Cancer Schmancer movement pro-
motes the Trash Cancer prevention program, which
is dedicated to shifting the trajectory of disease. The
program challenges consumers to question what they
put in, on and around them while theyre at home.
The home is the most constant place we spend the
most time, she says. Its the one place we have the
most control over.
When Drescher mentions the word control, shes
talking about controlling or eliminating our exposure
to carcinogens through environmental toxins that we
sometimes willingly assault our bodies with on a daily
basis. To back this up, she says that before a woman
walks out the door in the morning, on average, she has
used at least 12 personal care items. Men, on average,
use eight.
institutions as the Memorial Sloan Kettering Cancer
Center, the Womans Cancer Research Institute at
Cedars-Sinai Outpatient Cancer Clinic, and even the
Walter Reed Army Medical Center. Yet the movement
is just getting started.
Its a work in progress, Drescher says. There were
times when it was hard, when there was just me and
two other women. It was so much work I thought it
was going to kill me. I thought Id get cancer from
trying to help people not get cancer! We fortunately
now have a staff where we can get by, but were a lean,
mean organization.
Lean, mean, and effective. Drescher and her orga-
nization are responsible for the unanimous passage of
Johannas Law by all 100 senators. Ofcially known as
the Gynecologic Cancer Education and Awareness
Act, the bill is named for Johanna Silver Gordon,
who died from ovarian cancer in 2000. President
George W. Bush signed the bill into law on January
12, 2007, which allocated millions of dollars to the US
Department of Health and Human Services to launch
a national campaign in 2008 to educate American
women and health professionals about the signs and
symptoms of gynecologic cancers.
Were very proud that we successfully passed that
act, Drescher says. All 100 senators said yes! We
are now very excited about our next policy initiative,
which is to come up with a full, deceit-free label for
products. Its a bipartisan bill that will offer manu-
facturers a government seal of approval that they are
selling a carcinogen-free product.
The way this program would work is that compa-
nies would agree to submit their product to a third
party lab at their own expense to determine if the
ingredients in their product are harmful or not.
The goal is to force companies to put out a label
that the average consumer can understand, she says.
Customers shouldnt have to have a degree from MIT
to gure out whats in the product theyre buying.
Changing the Healthcare Landscape
Cancer Schmancer also recently partnered with
Humana Inc., one of the nations leading health and
well-being companies, to promote its Trash Cancer
initiative.
I applaud Humana with what theyre doing with
their own vitality program, Drescher says. Theyre
trying to shift from a health insurance company
to being a company that helps prevent disease and
encourages people not to get sick in the rst place.
They do this by creating incentive programs for peo-
ple to stay healthy. Its a philosophy that I hope other
companies will follow. Hopefully, the dinosaurs who
Cancer Schmancers
Gynecologic
Cancer Cheat Sheet
In the United States, more than 83,000
patients are diagnosed with a gynecologic cancer
annually.
*
The three most common gynecologic
cancers are uterine, ovarian, and cervical cancer.
Each cancer may have a variety of symptoms and
associated risk factors that may include:
Risk Factors:
I am not getting screened regularly with a
Pap test
I am at high-risk for human papillomaviruses
(HPV)
I smoke
I am very overweight
I eat a diet high in fat
I am a woman older than age 60
I started menstruating at an early age
before age 12
I take hormone replacement therapy (HRT)
drugs
Warning Symptoms:
Indigestion, heartburn, nausea, or gas
Abdominal swelling or discomfort
Pelvic pain or cramping
Bloating or a sense of fullness, even after
small meals
Backache
Painful, frequent, or burning urination with
no infection
Diarrhea or constipation
Loss of appetite or unintentional weight
loss or gain
Vaginal bleeding or irregular periods
Unusual vaginal bleeding or discharge after
menopause
Pain during intercourse
These symptoms can often be similar to other
diseases and conditions. However, if you are
experiencing any of the above symptoms, make
an appointment with your doctor right away. You
should discuss which of the following screen-
ing and diagnostic tools may be appropriate for
you: PAP Test, CA 125 Blood Test, Trans-vaginal
Ultrasound, Biopsy.
* Available at: http://www.cdc.gov/cancer/
gynecologic/. Accessed December 20, 2012.
resist this change, the elected ofcials and doctors still
subscribing to 20
th
century ideas about healthcare will
fall by the wayside.
In this regard, Cancer Schmancer and Life
Extension share the common philosophy that the best
way to battle disease and increase longevity is to avoid
getting a disease in the rst place.
Nobody goes through life unscathed, Drescher
says. For me, turning pain into purpose is very heal-
ing. I really feel like I got famous, I got cancer, and
now this is my lifes mission.
To complete her mission, Drescher says that she
takes care of herself now more than ever. She eats
more organic, more vegan, and is more natural in her
lifestyle.
You really need to think of your health rst and
factor in as many stress-reducing, health-boosting
strategies as you can, she says. When you have a
compromised immune system your body cant battle
the way it needs to. The more you deplete your body,
the more youre setting yourself up for failure.
For Drescher, failure, either with her own health, or
concerning her mission with the Cancer Schmancer
movement, is not an option.
Im just an average person who didnt even nish
college, but Im a US citizen and Im very patriotic
and I care about the health of the people in our coun-
try, she explains, the passion coming through in her
voice. The United States is still the beacon of light on
this planet. What were doing to raise awareness with
cancer prevention, through our website, through our
organization, and through articles like this with Life
Extension is hopefully shifting the course of the health
of the American people and having a domino effect on
the rest of the world when it comes to battling cancer.
For more information on Fran Drescher

or the Cancer Schmancer organization,
visit: www.cancerschmancer.org

Women today face a growing number of health issues, including
the need to support DNA gene structure in the breast. Detrimental
factors such as the aging process, along with the daily bombardment
of environmental estrogen-like compounds, demonstrate the need to
support a womans breast cellular structure.
A wealth of research shows that specic botanical extracts can
positively inuence cellular status and remove some of the anxiety
women face about maintaining a healthy balance of estrogens.
Two important metabolites that estrogen is broken down
to in the body are: the good 2-hydroxyestrone and the bad
16 alpha-hydroxyestrone. Scientists have identied nutrients like
indole-3-carbinol (I3C) that can tip the delicate balance of
estrogens in favor of the good form.
Women seeking to proactively restore their youthful hormonal
balance can now take a new, phytonutrient-based formula that
helps support healthy estrogen activity and detoxication. Some of
the active ingredients in the Breast Health Formula are:
Phytoestrogens that function as selective estrogen receptor
modiers help block certain estrogen receptor sites on
cells, thus preventing bad estrogen from exerting its
harmful effects
PIant Iignans that boost benecial enterolactone levels and
favorably alter estrogen metabolism
Cruci!erous VegetabIe Extracts (such as I3C) that effectively
increase 2-hydroxyestrone while reducing undesirable 16
alpha-hydroxyestrone
CaIcium D-GIucarate to safely facilitate the removal of
harmful estrogen from the body
Vitamin D to promote healthy genetic regulatory switching
to aging cells
reast HeaIth formuIa provides nutrients that have
demonstrated broad-spectrum support for preserving optimal
breast health.
The retail price for 60 vegetarian capsules of reast HeaIth
formuIa is $34. If a member buys four bottles, the price is reduced
to only $22.50 per bottle. Contains soybeans.
ActiFlax is a trademark of Pharma Science Nutrients, Inc., all rights reserved;
SoySelect
is a registered trademark of Indena S.p.A.; HMRlignan trademark is used under

license from Linnea SA; Sawasabi is a trademark of B&D Nutritional Ingredients, Inc.
Novasoy
is a registered trademark of Archer Daniels Midland company.

To order, call toll-free
1-800-544-4440 or visit
www.LifeExtension.com/breasthealth
Preserve OptimaI
REA5T HEALTH
The daily dose of two capsules supplies:
Cruciferous Vegetable Proprietary Blend 550 mg
Broccoli (Brassica oleracea I.) GMO-free Extract
[standardized to 4% glucosinolates]
Watercress (Nasturtium ofcinale) 4:1 extract (leaf)
Sawasabi
Wasabi (Wasabia japonica) powder (rhizome)

[standardized to 12,000 ppm Total Isothiocyanate]
Indole-3-Carbinol (I3C) 100 mg
Isoavones (from Novasoy

soy isoavone 35 mg
concentrate)
DIM (3,3-Diindolylmethane) 14 mg
D-Glucarate 137.5 mg
Vitamin D3 (as cholecalciferol) 1000 IU
Enterolactone Precursors Proprietary Blend 25 mg
HMRlignan
Norway spruce (Picea abies) standardized

lignan extract (knot wood) and Secoisolariciresinol
diglucoside from ActiFlax
ax (Linum usitatissimum L.)

lignan extract (seed)
Iodine (as potassium iodide) 2 mg
These statements have not been evaIuated by the food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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The Next-Generation Pomegranate Formula
Life Extension
oers an advanced, cutting-edge pomegranate

formula that brings together novel phytonutrients for the rst
time in a unique, high-potency blend.
Full-Spectrum Pomegranate combines standardized extracts
from the whole fruit and ower, along with pomegranate seed
oil, to support system-wide health. In addition to the highly
absorbable antioxidant powerhouses found in pomegranate fruit,
2-4

Full-Spectrum Pomegranate augments these polyphenols with
newly discovered biologically active compounds from other parts
of the pomegranate plant.
These little-known nutrients include: punicanolic acid, a member
of the triterpene family of essential oils that provides cellular
support to help with inammation,
5
and pomegranatate, to
combat age-related metabolic changes.
6
This superior formula supplies the complete nutritional prole
of the pomegranate plant. Just one softgel of Full-Spectrum
Pomegranate provides polyphenols equivalent to 12.3 ounces
of pomegranate juice concentrate (or 30 pomegranates) plus a
proprietary blend of seed oil and ower extract.
One softgel of Full-Spectrum Pomegranate contains:
POMELLA
Pomegranate .......................................... 400 mg

(Punica granatum) Extract (fruit) [std. to 30%
punicalagins (120 mg)]
PomComplete Pomegranate ............................... 137.5 mg
(Punica granatum) Blend [ower extract and
seed oil (standardized to 22% (30 mg) punicic acid)]
Full-Spectrum Pomegranate
A bottle containing 30 softgels of Full-Spectrum Pomegranate
retails for $24. If a member buys four bottles, the price is reduced
to $15.75 per bottle. Item # 01423
Contains soybeans.
References:
1. J Ethnopharmacol. 2007 Jan 19;109(2):177-206.
2. Eur J Nutr. 2003 Jan;42(1):18-28.
3. J In amm (Lond). 2009;6:1.
5. Chem Pharm Bull (Tokyo). 2008 Nov;56(11):1628-31.
6. Fitoterapia. 2006 Dec;77(7-8):534-7.

Comprehensive Pomegranate Protection!
Few nutritional sources have gained as much scientic
validation as pomegranate.
1
The vast majority of research has focused on extracts
from the fruit. Only recently have scientists identied the
synergistic action of compounds specic to other parts of
the pomegranatemost notably its seeds and owers.
To order Full-Spectrum Pomegranate,
call 1-800-544-4440
POMELLA

extract is covered under U.S. Patent 7,638,640 and POMELLA
is a registered trademark of Verdure Science, Inc.

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e pomegranateeeeeeeeeeeeeeeeeeee
s for the rst
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ed the
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owers.
Item #
DHEA and 7-Keto DHEA Levels Decline with Advancing Age
7-Keto DHEA Levels**
M
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/
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a
y

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e
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i
n

u
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i
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Age 25 30 35 40 45 50 60
40
30
20
10
0
DHEA Levels*
S
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r
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m

l
e
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e
l
s

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0

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)
Age
400
350
300
250
200
150
100
50
0
20 30 40 50 60
*Source: Orentreich, 1984. **Source: Marenich, 1979.
To order 7-Keto DHEA or DHEA Complete,
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For those seeking to combine the multiple
benefits of DHEA and 7-Keto DHEA in a
single formula, DHEA Complete provides 25
mg of regular DHEA and 100 mg of 7-Keto
DHEA per capsule. A bottle containing 60
100-mg vegetarian capsules of 7-Keto DHEA,
along with 25 mg of regular DHEA and a
special antioxidant blend, retails for $48; if
a member orders four bottles, the price is
reduced to only $32.40 per bottle.
A bottle containing 60 100-mg vegetarian
capsules of 7-Keto DHEA, along with a
special antioxidant blend, retails for $40; if
a member orders four bottles, the price is
reduced to only $27 per bottle.
7-KETO
DHEA
These supplements should be taken in conjunction with
a healthy diet and exercise program. Results may vary.
Note: Those with hormone-sensitive cancers should avoid regular
DHEA, but this caution does not apply to 7-Keto DHEA. Unlike
regular DHEA, 7-Keto
does not increase testosterone or estrogen

levels in the body.
References
1. Leowattana W. Clin Chim Acta.2004 Mar;341(1-2):1-15.
2. Labrie F, Belanger A, Cusan L, Gomez JL, Candas B. J Clin Endocrinol Metab. 1997
Aug;82(8):2396-402.
3. Hinson JP, Raven PW. Endocrinol.1999 Oct;163(1):1-5.
4. Kalman DS, Colker CM, Swain MA, Torina GC, Shi Q. Curr Therap Res. 2000;61(7):435-42.
7-Keto DHEA safely increases fat-burning enzymes in the
liver. Human subjects who consumed 200 mg of 7-Keto DHEA
in conjunction with a diet and exercise program lost more
weight than those who took a placebo.
4

To augment the fat-loss benefits of diet and exercise, Life
Extension offers 100-mg 7-Keto DHEA vegetarian capsules
and a supplement called DHEA Complete that contains 25 mg
of DHEA and 100 mg of 7-Keto DHEA in each capsule.
DHEA is the bodys most abundant circulating hormone, but its production peaks in ones twenties and
steadily declines thereafter, leading to age-related hormonal imbalances that can affect quality of life.
1-3
The bodys production of 7-Keto DHEA, a natural metabolite of DHEA, also declines markedly with age.
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7-Keto is a registered trademark of Humanetics Corporation.
C
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R
I
S
K
S
Shampoos, pesticides, drinking water, plastics, and vehicle
emissions contain cancer-causing toxins that we are exposed to
on a daily basis.
These chemicals can ultimately lead to cancer by damaging
our DNA and impeding our detoxification pathways.
1-4
In a cruel
twist, some of these toxins even activate cancer-causing genes
that could otherwise have remained dormant.
5,6
Today, it is impossible to avoid the constant onslaught of envi-
ronmental toxins. But what is possible is to equip your body with
the tools it needs to identify toxins and remove them from your
system before they can cause any damage.
Cruciferous vegetables do just that. They optimize your
bodys detoxification system in order to neutralize many of
these chemical threatsand maintain the integrity of your DNA in
the process.
7-9
Decades of research have shown that ingesting crucifer-
ous vegetables can slash risk of cancer by up to 54%.
10-18

These findings show reduced risk of virtually every major type of
cancer.
19-29
In this article, youll learn about the specific components of
cruciferous vegetables that fight cancerand, more importantly,
youll discover how to harness the powers of cruciferous vegeta-
bles to maximize their cancer-fighting benefits. >
Shield Yourself from
Environmental
CANCER RISKS

BY STEVE FRANKEL
Reducing the Effect of Environmental Toxins
Cruciferous vegetables (cabbage family, broccoli, cauliower, mustard
greens, and Brussels sprouts) are some of the most powerful cancer-ght-
ers nature has to offer. Numerous studies have shown that consuming
cruciferous vegetables can sharply reduce your risk of cancer.
10-18

Theyve been found to be effective against a vast array of cancers
including breast, prostate, colon, lung, bladder, ovarian, kidney, and more.
Compounds in cruciferous vegetables also have been found to provide
long-term anticancer protection even after theyve been cleared from
the body!
30,31
No other food group can boast such powerful, broad-reaching anti-
cancer benets. Weve known for years that people with the highest overall
intake of cruciferous vegetables experience a substantial reduction in the
risk of many kinds of cancernow were starting to understand why.
SHIELD YOURSELF FROM ENVIRONMENTAL CANCER RISKS
Our bodies are equipped with enzyme systems to
ght off toxic threats.
3,38
Unfortunately, if your enzyme
systems arent functioning properly, they can have the
opposite effect: They can activate those toxins, caus-
ing them to become even more lethally carcinogenic.
Making matters worse, some toxins suppress protec-
tive enzymes, impairing their ability to protect us from
cancer.
2,7,38-41
Thats where cruciferous compounds come in.
Cruciferous compounds help support the key enzyme
systems that are so vital for detoxifying your body of
harmful, cancer-causing environmental toxins.
9,42,43

The result is unprecedented protection from many of
the unavoidable cancer-causing toxins we face on a
daily basis.
Glucosinolates:
Powerful Chemoprevention
Among cruciferous vegetables many powerful
components, one group stands out. Theyre called glu-
cosinolates, which are found in broccoli and broccoli
sprouts. They are converted within the body to a num-
ber of active constituents that ght cancer through
multi-targeted mechanisms.
44-47
Research has shown that the compounds in cruci-
ferous vegetables have the ability to control cancers
on/off switch.
32-35
Essentially, they help ght against
cancer either by activating genes that prevent cancer,
or by suppressing genes that cause cancer.
36,37

Environmental toxins affect the growth and
spread of cancer. Pollutants found in air, water, soil,
and a large number of industrial products (espe-
cially plastics) contain toxins with cancer-causing
potential.
1-4
Arugu|a
B|ack and brown
mustard
Bok choy
Brocco|l
Brusse|s sprouts
Cabbage
Cau|lf|ower
Co||ard greens
Horseradlsh
1apanese radlshes
Ka|e
Koh|rabl
Parsnlps
Padlshes
Pape
Putabaga
Turnlps
Watercress
Wasabl
The Most Common
For example:
GIucosInoIaIes reduce IIe carcInogenIcIIy oI
nany envIronnenIaI IoxIns Ly LoosIIng IIe
geneIIc exressIon oI InorIanI deIoxIIyIng
enzynes.
8,48

TIey roIecI DNA Iron oxIdaIIve danage
caused Ly IoxIns (u Io 28% reducIIon In Iunan
researcI), IIereLy revenIIng IIe InIIIaI cIanges
IIaI can Iead Io cancer.
49

GIucosInoIaIe derIvaIIves encourage cancer ceIIs
Io connII suIcIde, and IIey suress genes IIaI
creaIe IIe nev LIood vesseIs IIaI suorI raId
grovII oI Iunors.
50

IInaIIy, IIere's evIdence IIaI gIucosInoIaIe derIva-
IIves can Iurn oII genes IIaI ronoIe IIe sread
oI cancer.
50
Because gIucosInoIaIes dIrecIIy aIIecI IIe IuncIIon
and exressIon oI genes (IIe eIgeneIIc eIIecI), exerIs
oInI ouI IIaI IIeIr roIecIIve eIIecIs are LoII vIde-
rangIng and Iong-IasIIng.
50
Hunan researcI reveaIs IIaI IIgIer dIeIary InIakes
oI glucosinolates are assocIaIed vIII a reducIIon In
rosIaIe cancer rIsk Ly 32%.
45
DerIvaIIves oI IIe gIu-
cosInoIaIes aLundanI In LroccoII srouIs IeI revenI
sIonacI cancer Ly kIIIIng IIe H. yIorI LacIerIun.
TIey aIso reduce synIons and LIonarkers oI Inlan-
naIIon In InIecIed IndIvIduaIs.
51
II's InorIanI Io noIe IIaI cookIng crucIIerous
vegeIaLIes reduces IIe raIe oI gIucosInoIaIe conver-
sIon Io acIIve noIecuIes Ly aLouI 300%, vIIcI Is one
good reason vIy suIenenIaIIon nay oIIer a LeIIer
aIIernaIIve.
52-54

Indole-3 Carbinol (I3C)
IndoIe-3-carLInoI (I3C) Is one oI IIe nosI vIdeIy-
sIudIed cononenIs oI crucIIerous vegeIaLIes. SIudIes
Iave sIovn IIaI II IeIs hgII cancers oI IIe LreasI,
rosIaIe, and reroducIIve IracI, as veII as coIon and
LIood cancers.
55

In cancers oI IIe reroducIIve IracI, I3C IeIs
revenI IIe deveIonenI oI Iunors Ly LeneIII-
IIng InorIanI raIIos oI esIrogen neIaLoIIIes sucI
as IIe 2-IydroxyesIrone:16_-IydroxyesIrone raIIo
and 2-IydroxyesIrone:esIrIoI raIIos.
56-5S
NoIe IIaI
2-IydroxyesIrone Is an esIrogen neIaLoIIIe IIaI seens
Io roIecI agaInsI cancer, vIereas 16-IydroxyesIrone
nay ronoIe cancer.
TreaInenI vIII I3C Ias aIso Leen sIovn Io Iave a
osIIIve eIIecI on recurrenI resIraIory aIIIonaIosIs,
a recancerous condIIIon IIaI roduces grovIIs In
Slash Your Cancer Risk with
Environmental toxins are a growing prob-

lem, threatening to raise already high rates
of preventable cancers.

While our bodies contain systems capable

of detoxifying harmful chemicals, some
enzyme systems in fact activate potential
carcinogens, making them more, not less,
likely to produce malignancy.

Toxins, radiation, and other forces exert

negative epigenetic effects on our chromo-
somes, potentially revealing cancer-caus-
ing genes for activation.

Phytochemicals from cruciferous vegeta-

bles can attack these natural cancer-pro-
moting processes at their root.

Cruciferous components work together

to inhibit toxin-activating enzymes, boost
detoxifying enzymes, and reverse negative
epigenetic changes in our chromosomes.

Because many such compounds are inacti-

vated by cooking, consider using a concen-
trated supplement containing extracts from
multiple types of beneficial cruciferous
plants.

the throat and voice-box. Studies show that treatment
with I3C completely stops the growth of papilloma in
about 33% of patients and reduces the growth rate
and need for surgery in another 33% of patients.
59,60
I3C is also benecial in early cervical cancers
known as carcinoma in situ. In one study, 50% of
the patients receiving 200 mg/day of I3C had com-
plete regression of carcinoma in situ, while none of
the patients in the placebo group were found to be free
of carcinoma in situ after 12 weeks.
61
And in women
with a potentially pre-cancerous condition known as
vulvar intraepithelial neoplasia, treatment with 200
or 400 mg/day of I3C reduced the size and severity of
lesions on the vaginal labia.
62
Animal studies of I3C show a reduction in tumor
number and size in experimental models of cancers
of the breast, lung, and prostate.
63-65
Di-indolyl-methane (DIM)
The compound DIM is produced in the body fol-
lowing ingestion of glucosinolates derived from cru-
ciferous vegetables. Animal models, basic lab studies,
and limited phase 1 clinical trials show that DIM pre-
vents tumors of the prostate, ovary, cervix, and thy-
roid, as well as several types of leukemia.
66-73
DIM also
appears to suppress cancer stem cells, the lingering,
super-potent cells that can cause a cancer to recur
even years after apparently successful treatment.
74,75

Beneficial Anticancer
Hormone Effects of
Many cancers, especially those of the repro-
ductive tissues, depend on the presence of sex
hormones (primarily estrogen and testosterone)
to sustain their growth. Therefore, many treatment
approaches rely on blocking or reducing levels of
sex hormones in cancer victims. The problem is,
conventional drugs can cause side effects and
may harm reproductive potential. Thats where
cruciferous vegetables come in.
Some components of cruciferous vegetables
act more gently and by multiple mechanisms to
impede the growth of such hormone-dependent
cancers, making them an important part of chemo-
prevention strategies.
Phenethyl isothiocyanate (PEITC), a natu-
ral metabolite of glucosinolates from watercress,
has been found, for example, to down-regulate
androgen receptors, minimizing stimulation of
prostate cancer by testosterone.
94
3,3-Diin-
dolylmethane (DIM), another glucosinolate
metabolic product, prevents stimulation of pros-
tate cancer cells by both androgens and estro-
gen.
69,95,96

Breast cancers are commonly estrogen-
dependent; sulforaphane and indole-3-car-
binol (I3C), still other glucosinolate products,
decrease the amounts of cancer-stimulating
estrogen receptor-alpha molecules present on
cells, inhibiting their proliferation.
97,98
This effect
has been shown to be active in thyroid cancers
as well, which are much more common in women
than in men.
66,99
DIM has a complementary effect,
stimulating cancer-suppressing estrogen recep-
tor-beta molecules.
100

Finally, a late 2012 study revealed that I3C
also induces degradation of the pro-cancer estro-
gen receptor alpha, and at the same time reduces
expression of tumor-promoting insulin-like growth
factor receptor-1 in breast cancer cells.
101
Thus, a single serving of a complete crucifer-
ous vegetable supplement can protect reproduc-
tive tissues from a whole array of harmful hormonal
influences, potentially making you much less likely
to develop these devastating malignancies.
Like the other components of cruciferous veg-
etables, DIM induces cancer cell death by apoptosis,
inhibits cancer cell growth, slows or stops new blood
vessel development in tumors, and can inhibit factors
allowing cancer cells to invade healthy tissue.
69

Like I3C, DIM helps prevent the growth of estro-
gen-dependent tumors, such as those of the female
breast and reproductive tract, by boosting the ratio of
2-hydroxyestrone:16_-hydroxyestrone.
66,76

Studies in mice demonstrate that DIM can com-
pletely prevent the progression of pre-cancerous
lesions of the cervix, caused by human papilloma virus
(HPV), to full-blown cancer.
77
In fact, researchers now
theorize that DIM could possibly make the human
papilloma virus vaccine more effective, so that it could
be given to women already infected with the virus.
(Currently it is only effective prior to infection.)
77
DIM
also increases levels of protective interferon gamma in
mouse models of cervical cancer.
68

Watercress Extract
One particular cruciferous vegetable, watercress,
brings together the very best actions of the other cru-
ciferous vegetables and their components weve dis-
cussed so far. Studies have shown that watercress has a
positive effect on lung, colorectal, and prostate cancers.
Watercress is especially rich in another gluco-
sinolate derivative, called phenethyl-isothiocyanate
(PEITC).
78
PEITC inhibits carcinogen-activating
enzymes, induces cancer detoxication enzymes, and
protects against DNA damage.
78,79
PEITC is also a
remarkably specic epigenetic modulator that turns
on genes that suppress cancer.
80,81

Cancer Risk Reduction by Cruciferous Vegetables
Cancer Type Risk Reduction
Colorectal 49%
13
Melanoma Skin Cancer 46%
17
Prostate 42%
20
Pancreas 34%
19
Kidney 32%
15
Bladder 31%
11
Esophagus 28%
12
Ovary 24%
18
Lung 22%
16
Breast 17%
12
Mouth and Throat 17%
12
These effects make watercress extracts particu-
larly appealing in the case of some of our most potent
environmental carcinogens, such as those found in
tobacco smoke.
82-84
Watercress and PEITC are also
showing promise in other malignancies caused by
activated carcinogens, such as colorectal and prostate
cancers.
85-87
Look for supplements that contain watercress
extract, rather than puried PEITC, because the
watercress extracts also contain small amounts of
other detoxifying enzyme inducers with even greater
potency.
78
These substances help prevent cancer
growth by reducing inammatory stimuli such as
nitric oxide.
88
How to Get the Most Benefit
from Cruciferous Vegetables
In order to get the maximum health benets from
cruciferous vegetables, make sure youre consuming
a variety of them. Every member of the cruciferous
family contains a different set of the glucosinolates
that help ght cancer.
For example, broccoli, Brussels sprouts, and
cabbage are good sources of a glucosinolate called
glucoraphanin, the precursor of sulforaphane.
Watercress is an excellent source of the glucosinolate
gluconasturtiin, the precursor of PEITC. And garden
cress, cabbage, and Indian cress are top sources of a
glucosinolate known as glucotropaeolin, the precur-
sor of benzyl isothiocyanate (BITC).
This table shows the reduction in
risk for various cancer types, for
those consuming the highest versus
the lowest amounts of cruciferous
vegetables.
Next, make sure theyre not overcooked.
Boiling, steaming, and microwaving at high
power substantially decreases the bioavail-
ability of cruciferous vegetables cancer-
ghting compounds.
89-92
As benecial for you
as cruciferous vegetables are, there are some
things you need to be aware of: The glucosino-
late content varies greatly even among individ-
ual plants of the same typeand even among
parts of the same plant. Even these relative
concentrations change during the course of a
single plants growth cycle.
93

Thats why, in addition to eating a variety
of cruciferous vegetables, its important to take a
standardized cruciferous compound supplement. A
good cruciferous vegetable supplement should con-
tain I3C, DIM, and PEITCand for even greater
impact, should also include extracts of raw broccoli,
cabbage, watercress, and other plant compounds
such as apigenin.
Several plant extracts complement the detoxify-
ing and epigenetic effects of cruciferous vegetables,
making them valuable additions to a comprehensive
cancer-prevention supplement. The three most potent
ones include apigenin, cats claw, and rosemary.
1. Apigenin is a bioflavonoid found in celery, pars-
ley, and some other plants that has known chemo-
preventive effects. These include stopping the cell
reproductive cycle, inducing cancer cell death by
apoptosis, preventing metastasis, and slowing new
blood vessel formation.
102-105
Clinical studies show
that 20 mg/day of apigenin, in combination with 20
mg/day of the green tea extract EGCG, drastically
reduced the rate of colon cancer recurrence following
surgical treatment (only 7% of treated patients had
recurrences, while 47% of the control patients had
recurrences).
106
Apigenin shows promise in labora-
tory and animal studies of cancers of the mouth, skin,
and pancreas, as well as in leukemia.
102,104,107-109
2. The second extract that can be used to comple-
ment cruciferous compounds is called Cats Claw
(Uncaria tomentosa). Lab studies have shown that
Uncaria extracts are effective against tumor cells from
breast, cervical, lung, thyroid, and colon cancers as
well as leukemia.
110-112
Uncaria extracts contain pow-
erful antioxidants that protectand can even repair
DNA from environmental damage.
113,114
The result is
protection from cancer, especially in organs with a
rapid rate of cell turnover, such as skin, colon, and
lung, where a small amount of DNA damage can have
a rapidly accumulating pro-cancer effect. Uncaria
extracts reduced reductions in immune function after
chemotherapy while inducing programmed cell death
(apoptosis) in malignant cells.
110,111,115-117
3. Rosemary extracts have shown effectiveness in
lab studies of colon, skin, and ovarian cancers, and
leukemia.
118-124
Rosemary is capable of enhancing
the ability of the body to rid itself of potential car-
cinogens.
125,126
In addition, rosemary offers remark-
able protection against radiation, shielding cells of
the blood and gastrointestinal tract in particular from
radiations ionizing and oxidizing effects.
127-130
Rose-
mary slows or stops DNA damage and tumor cell
proliferation, induces apoptosis of tumor cells, and
markedly suppresses genes that enable tissue inva-
sion and metastatic spread.
118,131-133
Currently, oncolo-
gists are giving special attention to the combination
of rosemary extracts plus vitamin D3and for good
reason. Together, these supplements promote normal
cell differentiation into mature, non-cancerous white
blood cells, helping prevent conversion into leukemia
cells.
124,134
Extracts that Complement Cruciferous Vegetables
Summary
Environmental toxins are major causes of cancer.
They cause damage to our DNA and can activate can-
cer-causing genes that would otherwise have remained
dormant. Although its impossible to avoid these tox-
ins, you can arm your body with the tools it needs to
Rosemary
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15. Michaud DS, Spiegelman D, Clinton SK, Rimm EB, Willett WC,
Giovannucci EL. Fruit and vegetable intake and incidence of
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16. Cohen JH, Kristal AR, Stanford JL. Fruit and vegetable intakes
and prostate cancer risk. J Natl Cancer Inst. 2000;92:61-8.
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identify the toxins and remove them from your system
before they can cause any damage.
Cruciferous vegetables neutralize chemical threats
by optimizing your bodys detoxication system, by
maintaining the integrity of your DNA, and by activat-
ing the genes necessary to ght cancer. The result is
unprecedented cancer protection from the unavoid-
able assaults of daily living.
Many of the cruciferous vegetables constituents
hold up poorly under cooking and processing condi-
tions. Thats why the best way to consistently gain the
benets of cruciferous compounds is to lightly steam
the vegetables and/or obtain them in standardized
dietary supplements.


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47. Tian M, Bi W, Row KH. Multi-phase Extraction of glycoraphanin
from broccoli using aminium ionic liquid-based silica. Phytochem
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49. Verhagen H, Poulsen HE, Loft S, van Poppel G, Willems MI, van
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50. Dinkova-Kostova AT. Chemoprotection against cancer by iso-
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51. Yanaka A, Fahey JW, Fukumoto A, et al. Dietary sulforaphane-
rich broccoli sprouts reduce colonization and attenuate gastritis
in Helicobacter pylori-infected mice and humans. Cancer Prev Res
(Phila). 2009 Apr;2(4):353-60.
52. Conaway CC, Getahun SM, Liebes LL, et al. Disposition of gluco-
sinolates and sulforaphane in humans after ingestion of steamed
and fresh broccoli. Nutr Cancer. 2000;38(2):168-78.
53. Rouzaud G, Young SA, Duncan AJ. Hydrolysis of glucosinolates
to isothiocyanates after ingestion of raw or microwaved cabbage
by human volunteers. Cancer Epidemiol Biomarkers Prev. 2004
Jan;13(1):125-31.
54. Rungapamestry V, Duncan AJ, Fuller Z, Ratcliffe B. Effect of meal
composition and cooking duration on the fate of sulforaphane
following consumption of broccoli by healthy human subjects. Br
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Experience
Item # 00987
To order Natural Stress Relief
with Lemon Balm and L-Theanine,
call 1-800-544-4440 or visit
It Item emm###
T d N t l S
Overstressed? Losing sleep?
Left unchecked, the inner turmoil created by
these issues can lead to heart palpitations,
muscle weakness, headaches, and even
increased blood pressure. You need to take
action to halt these symptoms immediately.
Fortunately, Life Extension
has created
Natural Stress Relief, a calming formula
made with lemon balm and L-theanine, two
ingredients clinically proven to help promote
sleep and relaxation.
1-3

The Cyracos
lemon balm extract used in

this product is prepared from a special lemon
balm chosen for its high concentrations of
hydroxycinnamic and rosmarinic acids. These
potent constituents may be mood enhancers that
relieve everyday stress and alleviate sleep problems.
1
L-theanine, an amino acid derived from green tea,
is a natural relaxant that has been used by the Japanese
for years. Those who have taken L-theanine compare it to a
massage, meditation session, and aromatherapy rolled into one.
2
Based on a tremendous amount of published data, Life
Extension
combined these two ingredients with the idea of

providing the ultimate calming experience. Try it today.
Each vegetarian capsule of Natural Stress Relief provides:
300 mg of Cyracos
lemon balm extract

200 mg of Suntheanine
L-Theanine
Note that the amount of L-theanine in this product is
double that of most L-theanine stand-alone supplements.
The reason for this potency increase is reports of greater
benet when at least 200 mg of L-theanine are taken.
The retail price of a 30-count bottle of Natural Stress
Relief is $28. If a member buys four bottles, the price of
this potent stress-relieving formula is reduced to just
$18 per bottle.
BEWARE OF IMITATIONS The L-theanine used in the new Natural Stress Relief is Suntheanine
, the only
pure form of L-theanine available worldwide and the only form protected by 40 internationally recognized
patents and scientically proven in clinical studies to be safe and ecacious. Independent laboratory
analysis has veried that certain other products on the market claiming to contain L-theanine are only
half L-theanine, the other half being a dierent form of theanine known as D-theanine that has not been
scientically evaluated in published studies. Suntheanine
is a registered trademark of Taiyo International,

Inc. Use of Suntheanine
is protected by US Trademark Registration No. 2,548,957. Cyracos
is a registered
trademark of Naturex, Inc.
References:
1. Neuropsychopharmacology. 2003 Oct;28(10):1871-81.
2. J Herb Pharmacother. 2006;6(2):21-30.
3. Biochem Biophys Res Commun. 2004 Jul 16;320(1):116-22.
References:
1. Am J Clin Nutr. 1987;45:1305-12.
2. Clinica Chimica Acta. 2000;294:1-26.
According to the National Institutes of Health,
magnesium is required for more than 300
biochemical reactions in the body. Magnesium
helps maintain normal muscle and nerve
function, keeps heart rhythm steady, supports a
healthy immune system, and keeps bones strong.
Magnesium also helps maintain blood sugar levels
already within normal range, promotes normal
blood pressure, and is known to be involved in
energy metabolism and protein synthesis.
1,2
With so many of our bodys critical functions
dependent upon magnesium, supplementation
can help ensure that you obtain healthy levels
of this vital mineral. The recommended intake
of magnesium to maintain vascular health is
500 mg or more a day. With Life Extension
s
Magnesium Capsules you can easily obtain
500 mg of elemental magnesium in each
vegetarian capsule.
The retail price of a bottle containing 100
500 mg Magnesium Capsules is $10. If a member
buys four bottles, the price is reduced to just
$6.75 per bottle.
MOST AMERICANS DO NOT OBTAIN
SUFFICIENT MAGNESIUM FROM THEIR DIET.
To order Magnesium Capsules,
call 1-800-544-4440 or
Item #01369
Caution: If taken in high doses, magnesium may have a laxative eect. If this
occurs, divide dosing, reduce intake, or discontinue product.
Scientists have identied specic extracts from cruciferous
vegetablessuch as broccoli, cauliower, cabbage and Brus-
sels sproutsthat help maintain healthy hormone metabolite
balance. Triple Action Cruciferous Vegetable Extract com-
bines some of these plant extracts into a comprehensive
formula for optimal DNA protection.
I3C (indole-3-carbinol) and DIM (di-indolyl-methane)
favorably modulate estrogen metabolism and induce liver
detoxication enzymes to help neutralize potentially harmful
estrogen metabolites and xenoestrogens (estrogen-like
environmental chemicals).
1-4
Extracts of broccoli, watercress, and rosemary provide
glucosinolates, isothiocyanates, carnosic acid, and carnosol
bioactive compounds that have a multitude of favorable
eects on estrogen metabolism and cell division.
5-8
Apigenin,
a powerful plant avonoid found in plants such as parsley
and celery, is also added to the formula to boost cell protec-
tion,
9
while 25 mg of a natural source of benzyl isothiocyanate
(BITC), are included to maintain cell health.
10
Consumers should be aware that while consumption of cruci-
ferous vegetables is highly recommended, the cooking process
depletes many of the benecial compounds such as I3C.
For those weighing less than 160 pounds, just one capsule
a day provides optimal potencies. Those weighing over 160
pounds should consider taking two capsules a day. A 60 vege-
tarian capsules bottle of Triple Action Cruciferous Vegetable
Extract retails for $24. If a member buys four bottles, the
price is reduced to $16.50 per bottle.
To order Triple Action Cruciferous
Vegetable Extract, call 1-800-544-4440
Item # 01468 Item # 01469
REFERENCES
1. Biochem Pharm. 2002, 64;393-404.
2. Toxicol Appl Pharm. 2001 Jul 15;174(2):146-52.
3. J Natl Cancer Inst. 1997 May 21;89(10):718-23.
4. Cancer Detect Prevent. 2004;28:72-9.
5. Carcinogenesis. 2002 Apr;23(4):581-6.
6. Mol Cancer Ther. 2003 Oct;2(10):1045-52.
7. Carcinogenesis. 1998 Oct;19(10):1821-7.
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9. J Clin Biochem Nutr. 2009 May;44(3):260-5.
10. Food Chem Toxicol. 2008 Jul;46(7):2358-64.
CRUCIFEROUS
Vegetable Extract with Apigenin
TRIPLE ACTION
Triple Action Cruciferous Vegetable Extract provides the
following concentrates in just one vegetarian capsule:

Broccoli Extract 400 mg
[standardized to 4% glucosinolates (16 mg)]
Watercress 4:1 extract 50 mg
Indole-3-Carbinol (I3C) 80 mg
Rosemary Extract 50 mg
Cats Claw Extract 50 mg
Cabbage Extract 25 mg
DIM (di-indolyl-methane) 14 mg
Apigenin 25 mg
Those who want to obtain the benets of trans-resveratrol
can order Triple Action Cruciferous Vegetable Extract with
Resveratrol. Each capsule provides 20 mg of trans-resveratrol
in addition to the vegetable extracts and retails for $32 per
60-capsule bottle. When a member buys four bottles, the price
is reduced to $22.20 per bottle.
Contains corn.
Misconceptions
About
ATHERO-
SCLEROSIS
Atherosclerosis is the underlying cause of most heart attacks
and strokes, yet doctors remain confused as to how this artery-blocking
process occurs.
Most cardiologists overlook specific mechanisms that inflict arterial
wall damage and the ensuing progression to occlusive atherosclerotic
disease. The result is that only a few of the factors that accelerate
arterial blockage (such as elevated LDL) are addressed in todays
clinical setting.
Doctors think of an atherosclerotic lesion as a clog consisting
of fat, cholesterol, and platelets that have accumulated on an inner
arterial wall. As a result, they tell their patients to eat less fat, take a
statin drug (if cholesterol levels are high), and use a baby aspirin to
prevent arterial platelet aggregation. The problem with these
approaches is that while they may postpone a heart attack or stroke,
they fail to correct the underlying pathologies that cause athero-
sclerotic lesions to form and progress.
If people are to live long lives free of the ravages of athero-
sclerosis, these lethal misconceptions must be cleared up. Otherwise,
there will be an epidemic of aging people receiving coronary stents,
undergoing bypass surgeries, and dropping dead from sudden heart
attacks. >
BY WILLIAM FALOON
A
T
H
E
R
O
S
C
L
E
R
O
S
I
S
Why Arteries Clog as We Age
The aging process damages blood vessels, even when conventional risk
factors such as cholesterol and blood pressure are within normal ranges.
For over 40 years, the standard treatment for coronary atherosclerosis
has been to bypass the blocked arteries. Recuperation from this procedure
can take months, and some patients are aficted with lifetime impairments
such as chronic inammation, memory loss, and depression.
1-11
Stenting open narrowed coronary arteries has become prevalent over the
past decade, but this procedure is not a cure for underlying systemic endo-
thelial dysfunction and atherosclerosis.
MISCONCEPTIONS ABOUT ATHEROSCLEROSIS
endothelial cells whose integrity is crucial if athero-
sclerosis is to be prevented.
Poor health habits and normal aging result in
endothelial dysfunction, a process in which the
endothelium boundary is broken, arterial exibility
is diminished, abnormal platelet aggregation occurs,
and atherosclerotic lesions form in response to arte-
rial wall (endothelium) injuries.
How Do Most Heart Attacks
and Strokes Occur?
The two prime factors involved in occlusive arte-
rial disease are abnormal platelet aggregation and
endothelial dysfunction. When the endothelium is
not functioning properly, our platelets (blood-clotting
cells) become dangerously over-activated. This can
cause a sudden arterial blood clot, or contribute to
progression of atherosclerosis by stimulating inam-
mation.
A primary mechanism involved in endothelial
dysfunction is the depletion of nitric oxide, often
caused from the oxidation of LDL and other blood
components. Nitric oxide is produced by endothelial
cells. It regulates vascular elasticity, maintains cardiac
contraction, prevents vessel injury, and helps protect
against atherosclerosis.
59-62
As humans age, endothelial function becomes
altered. Due to a variety of insults, a depletion of nitric
oxide occurs in the endothelium. One consequence of
nitric oxide depletion is the inability of arteries to
expand and contract with youthful elasticity. The con-
tinual stiffening and occlusion of aged arteries is the
number one health risk that people in Western soci-
eties face.
63-68
In order to maintain healthy arterial
dilation, the endothelium has to manufacture enough
nitric oxide. Impairment in nitric oxide release by the
aging endothelium causes arterial dysfunction.
69,70
Therapies used by todays mainstream cardiologists
(aspirin, statin, and certain anti-hypertensive drugs)
have a benecial effect on the endothelium, but they
may only postpone a serious vascular event. If a per-
son lives long enough, the chronic depletion of endo-
thelial nitric oxide results in impairment of arterial
function and progressive restriction of blood ow to
vital parts of the body.
Summary
Endothelial cells line the arteries, veins, arterioles,
and capillaries of the vascular system. Doctors used
to view the endothelium as a relatively inert struc-
ture that played no active role in vascular function.
Starting around 20 years ago, research has shown that
A review of the scientic literature reveals that
atherosclerosis is associated with high blood levels
of homocysteine,
12-14
brinogen,
15-18
C-reactive pro-
tein,
12,15,19-26
glucose,
27,28
cholesterol,
29-32
insulin,
33-36
iron,
37-40
LDL,
41-44
and triglycerides,
45-48
along with
low levels of HDL
49-52
and testosterone (in men).
53-58
Optimizing blood levels of these substances can dra-
matically reduce heart attack and stroke risk.
Despite thousands of studies validating that ath-
erosclerosis is a multifactorial process, todays doctors
often prescribe a statin drug as the sole therapy to pre-
vent and treat coronary atherosclerosis. Mainstream
cardiologists fail to appreciate that coronary athero-
sclerosis is a sign of systemic arterial dysfunction
requiring aggressive therapy to correct.
Anatomy of the Artery
Arteries are the blood vessels that bear the full
force of each heartbeat. Most people think of arteries
as exible tubes whose only function is to carry blood
that ows continuously throughout the body. In fact,
arteries are dynamic, functioning muscular structures
that, when healthy, expand and contract to facilitate
circulation and maintain optimal blood pressure.
The outer layer of the artery comprises mostly con-
nective tissue and provides structural containment for
the two layers beneath. The middle area comprises
elastic smooth muscle that provides the contractile
strength to make possible the arterys expansion and
contraction with each heartbeat. The inner layer,
known as the endothelium, comprises a thin area of
Cross-section of an artery demonstarting plaque.
Endothelium
Smooth muscle cell
infiltration into
the endothelium
Atherosclerotic
plaque
the endothelium is dynamic and participates in vital
aspects of arterial structure and function.
74
Over the years, Life Extension
has reported
on advances related to protecting the endothelium
against age-related deterioration, such as the remark-
able ability of pomegranate to reverse clinical mea-
surements of systemic atherosclerosis (in both carotid
and coronary arteries).
75-81
A typical 50-year-old human can postpone a major
cardiovascular event by following relatively simple
steps, such as eating healthy and taking a low-dose
statin drug if LDL is over 100 mg/dL. As that same
person ages, however, multiple processes involved in
endothelial dysfunction too often manifest in the
form of a vascular-related disorder.
Endothelial cells that line blood vessels are crucial
to maintaining vascular integrity. Endothelial dys-
function is a critical factor in the initiation and pro-
gression of cardiovascular disease,
82-84
yet mainstream
doctors continue to ignore this dominant underlying
cause of arterial occlusion. Pomegranate extracts
protect against endothelial dysfunction via several
well-dened mechanisms, including protection of
vital endothelial nitric oxide.
85-87

Atherosclerosis remains the number-one cause of
death and disability in the United States.
88
The graphic
on the next page shows 17 independent risk factors
of atherosclerosis, with low EPA/DHA blood levels
being only one of the elements that must be controlled
if heart attack and ischemic stroke are to be averted.
Annual blood testing is critical to identifying ones
individual risk factors. Modest-dose sh oil alone will
not reverse the endothelial dysfunction that exists in
aging humans with preexisting atherosclerosis.
To read specically how atherosclerosis initiates
and progresses, refer to the next article.

Guard Against
Lethal Medical
Misconceptions
Doctors think of an atherosclerotic lesion

as a clog consisting of fat, cholesterol,
and platelets that have accumulated on an
inner arterial wall.
Despite thousands of studies validating

that atherosclerosis is a multifactorial
process, todays doctors often prescribe
a statin drug as the sole therapy to prevent
and treat coronary atherosclerosis.
Stenting open narrowed coronary arteries

has become prevalent over the past
decade, but this procedure is not a cure
for underlying systemic endothelial
dysfunction and atherosclerosis.
The aging process damages blood vessels,

even when conventional risk factors such
as cholesterol and blood pressure are within
normal ranges.
A review of the scientific literature reveals

that atherosclerosis is associated with high
blood levels of homocysteine, fibrinogen,
C-reactive protein, glucose, cholesterol,
insulin, iron, LDL, and triglycerides, along
with low levels of HDL and testosterone
(in men).
Poor health habits and normal aging result

in endothelial dysfunction, a process in
which the endothelium boundary is broken,
arterial flexibility is diminished, abnormal
platelet aggregation occurs, and athero-
sclerotic lesions form in response to arterial
wall (endothelium) injuries.
A primary mechanism involved in endothelial

dysfunction is the depletion of nitric oxide,
often caused from the oxidation of LDL and
other blood components.
Annual blood testing is critical to identifying

ones individual risk factors.
72 | LIFE EXTENSION | APRIL 2013 72 | LIFE EXTENSION | APRIL 2013
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71-73
The reason is simple. Aging arteries are
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Compromised arterial ow
17 DAGGERS OF ARTERIAL DISEASE
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pathologic remodeling from chronic pressure load. J Clin Invest.
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63. Aikawa K, Saitoh S, Muto M, et al. Effects of antioxidants on cor-
onary microvascular spasm induced by epicardial coronary artery
endothelial injury in pigs. Coron Artery Dis. 2004 Feb;15(1):21-30.
64. Angdin M, Settergren G, Starkopf J, Zilmer M, Zilmer K, Vaage J.
Protective effect of antioxidants on pulmonary endothelial func-
tion after cardiopulmonary bypass. J Cardiothorac Vasc Anesth.
2003 Jun;17(3):314-20.
65. Meydani M. Dietary antioxidants modulation of aging and
immune-endothelial cell interaction. Mech Aging Dev. 1999
Nov;111(2-3):123-32.
66. Schubert SY, Neeman I, Resnick N. A novel mechanism for the
inhibition of NF-kappaB activation in vascular endothelial cells
by natural antioxidants. FASEB J. 2002 Dec;16(14):1931-3.
67. Schulz E, Anter E, Keaney JF Jr. Oxidative stress, antioxidants,
and endothelial function. Curr Med Chem. 2004 May;11(9):
1093-104.
68. Taddei S, Virdis A, Ghiadoni L, et al. Age-related reduction of NO
availability and oxidative stress in humans. Hypertension. 2001
Aug;38(2):274-9.
69. Rubio AR, Morales-Segura MA. Nitric oxide, an iceberg in cardio-
vascular physiology: far beyond vessel tone control. Arch Med Res.
2004 Jan-Feb;35(1):1-11.
70. Sugawara J, Komine H, Hayashi K, et al. Effect of systemic nitric
oxide synthase inhibition on arterial stiffness in humans. Hyper-
tens Res. 2007 May;30(5):411-5.
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1-9
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Fish oils (and other fatty acids) have a tendency to oxidize,
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that when added to sh oil, sesame lignans safeguard against
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10
To further emulate the benets of a Mediterranean diet,
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11

Olive also contains the compounds hydroxytyrosol, tyrosol,
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12-15

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Take two softgels twice daily with meals.
A bottle containing 120 softgels of Super Omega-3 EPA/DHA
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If a member buys four bottles, the price is reduced to $21 per
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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
For those with sensitive stomachs, Super Omega-3 is also available
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l ) f SUPER OMEGA 3
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A bottle containing 240 half-size softgels of Super Omega-3
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CAUTION: If you are taking anti-coagulant or anti-platelet medications, or have a bleeding
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Supportive but not conclusive evidence shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary
heart disease. IFOS certifcation mark is a registered trademark of Nutrasource Diagnostics, Inc. These products have been tested
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References
1. Public Health Nutr. 2006 Dec;9(8A):1136-40.
2. Am J Prev Med. 2005 Nov;29(4):335-46.
3. J Am Diet Assoc. 2005 Mar;105(3):428-40.
4. Mini Rev Med Chem. 2004 Oct;4(8):859-71.
5. Nurs Stand. 2004 Aug 11-17;18(48):38-42.
6. Cleve Clin J Med. 2004 Mar;71(3):208-10, 212,
215-8 passim.
7. J Nutr Health Aging. 2001;5(3):144-9.
8. Inamm Res. 2001 Feb;50(2):102-6.
9. Arch Intern Med. 2000 Mar 27;160(6):837-42.
10. Biochem Biophys Acta. 2004 Jun 1;1682(1-3):80-91.
11. Nutrition. 2005 Feb;21(2):131-6.
12. Anal Chim Acta. 2007 Feb 5;583(2):402-10.
13. J Agric Food Chem. 2007 Sep 5;55(18):7609-14.
14. Lipids. 2001 Nov;36(11):1195-202.
15. Eur J Cancer. 2000 Jun;36(10):1235-47.
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1-17
Hawthorn: Peak Cardiotonic Support
Used for centuries in Europe for heart health, the cardiotonic efects of
Hawthorn extract have been well documented in numerous clinical trials.
1,9-12

Hawthorn contains specifc biofavonoid complexes targeted to help
promote normal circulation and efcient heart muscle function.
2,5,13
Studies indicate that the constituents in Hawthorn powerfully support:
- Strong contractile force of human heart muscle.
3
- Protection for heart muscle cells from oxidant damage.
1,2
- Normal gene expression to promote cardiovascular health.
2,4,5
- Improved cardiovascular performance.
11
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References
1. Am J Chin Med. 2005;33(1):1-10.
2. Zhongguo Zhong Yao Za Zhi. 2009 Jan;34(1):96-9.
3. J Cardiovasc Pharmacol. 2000 May;35(5):700-7.
4. Arzneimittelforschung. 1993 Sep;43(9):945-9.
5. Life Sci. 2004 Feb 27;74(15):1945-55.
6. J Assoc Physicians India. 2001 Feb;49:231-5.
7. Indian Heart J. 2004 Mar-Apr;56(2):123-8.
8. Life Sci. 2003 Oct 10;73(21):2727-39.
9. Fortschr Med. 1993 Jul 20;111(20-21):352-4.
10. Eur J Heart Fail. 2008 Dec;10(12):1255-63.
11. Fortschr Med. 1996 Aug 30;114(24):291-6.
12. Phytomedicine. 2011 Nov 15;18(14):1214-9.
13. Arzneimittelforschung. 1997 Jul;47(7):821-5.
14. Indian J Exp Biol. 2011 Apr;49(4):282-8.
15. Evid Based Complement Alternat Med. 2011;2011:487916.
16. J Ethnopharmacol. 2007 Nov 1;114(2):114-29.
17. Indian Heart J. 2002 Mar-Apr;54(2):170-5.

Rejuna is a trademark of Verdure Sciences, Inc
How
ATHERO-
SCLEROSIS
Develops in
Aging Humans
At least one of every two Americans over the age of 65 has
atherosclerosis.
1
It is so common in older people that some
experts used to think that it was part of the normal aging
process.
2
We are going to explain in detail here how atherosclerosis
develops, so you can fully understand why a modest dose of
fish oil alone is not going to reverse this process in those
with preexisting vascular disease.
While we understand that some members may find the
material in this article overly technical, it is important we
publish it so that our many physician members understand
the challenges in treating aging humans with significant
pre-existing atherosclerosis. >
BY WILLIAM FALOON
A
T
H
E
R
O
S
C
L
E
R
O
S
I
S
How Atherosclerotic Lesions Develop
Atherosclerosis begins with changes in endothelial cell function
that cause white blood cells moving through the blood to stick to
the endothelium (inner arterial wall) instead of owing by normally.
The endothelium then becomes weakened. This allows blood cells
and toxic substances circulating in the blood to pass through the
endothelium and enter the arterys sub-endothelial compartment.
Lipid or fat-like substances such as LDL and triglycerides in the blood
then accumulate in this area.
HOW ATHEROSCLEROSIS DEVELOPS IN HUMANS
rupture, can interfere with blood ow and cause an
acute heart attack.
Alternatively, atherosclerotic plaques can grow to
such a degree as to restrict blood ow severely. When
blood ow within an artery is gravely compromised
by a large plaque or blood clot, the cells of tissues
that depend on blood ow from that artery become
damaged or die. Coronary atherosclerosis cuts off the
hearts blood supply by occluding the hearts arteries,
which stops the oxygen supply to the heart, thus caus-
ing a heart attack. An ischemic stroke results when
atherosclerotic processes cut off the oxygen supply to
a portion of the brain.
As you can see, therefore, much more is involved
in the development of atherosclerosis than just high
cholesterol and LDL. We must emphasize, however,
that maintaining optimal LDL and cholesterol levels
is an important component of an atherosclerosis-
prevention program.
Protecting Your Arterial Walls
High blood pressure,
3-7
elevated LDL-cholesterol-
triglycerides,
8-13
low HDL,
14-17
smoking,
18-20
diabetes,
21-25

obesity,
26-30
and lack of exercise
31-33
contribute to endo-
thelial dysfunction and the subsequent development
of atherosclerosis.
Other signicant artery-damaging factors are
high-normal levels of glucose,
34
insulin,
35-39
iron,
40-43

homocysteine,
44-52
and brinogen,
53-55
and any level of
C-reactive protein
14,56-62
that is higher than optimal.
The lipids that accumulate in the broken endothe-
lium become oxidized, causing the smooth muscle
cells to try to repair the damaged endothelium. The
result of this repair process is smooth muscle cell inl-
tration into the endothelium causing the formation
of the initial atherosclerotic lesion. Depending on an
individuals risk factorssuch as poor diet, lack of
exercise, smoking, high blood pressure, and the aging
process itselffat accumulation continues and the
atherosclerotic process accelerates.
Immune cells called macrophages then invade the
damaged arterial area to digest the fat. But smooth
muscle cells that have migrated to the area have
already changed their nature to scavenge fat. These
fat-laden white blood cells and smooth muscle cells
are called foam cells, and provoke a chronic inam-
matory attack by various immune components.
Smooth muscle cells try to curtail the injury to the
endothelium by producing collagen, which forms a
cap over the injury site. Calcium then accumulates
over the injury site to form a material resembling
bone. This is why atherosclerosis used to be referred
to as hardening of the arteries.
This complex array of foam cells, calcication, and
lipid accumulation is called an atherosclerotic plaque.
The plaque grows, and if it becomes unstable, it is
vulnerable to acute rupture that exposes the contents
of the plaque to blood. Platelets can then rapidly accu-
mulate around this ruptured plaque, resulting in an
acute blockage (or blood clot) on the inner surface of
the blood vessel wall. This clot can become very large
and occlude the vessel. Even small plaques, if they
A 3-D spiral CT scan
of carotid atherosclerosis.
Inset: Plaque attached
to the wall of left internal
carotid artery. This
angiogram was taken
with a helicoidal scanner.

P
H
O
T
O
T
A
K
E
U
S
A
.
C
O
M
Homocysteine can induce the initial atheroscle-
rotic injury to the endothelium, then facilitate the oxi-
dation of the fat and LDL that accumulate beneath the
damaged endothelium, and nally contribute to the
abnormal accumulation of blood components around
the atherosclerotic plaque.
Fibrinogen is a clotting factor that accumulates at
the site of the endothelial lesion. Fibrinogen contrib-
utes to plaque buildup and can participate in the arte-
rial blockage after an unstable atherosclerotic plaque
ruptures.
Glucose at high-normal levels may accelerate the
glycation process that causes arterial stiffening, while
high-normal fasting glucose and insulin inicts direct
damage to the endothelium. High levels of iron pro-
mote oxidation of LDL in the damaged endothelium,
while low levels of testosterone (in men) appear to
interfere with normal endothelial function.
C-reactive protein is an inammatory marker and
directly damages the endothelium. Chronic inam-
mation, as evidenced by persistent high levels of
C-reactive protein, not only creates initial injuries to
the endothelium, but also accelerates the progression
of existing atherosclerotic lesions.
In response to a large number of published studies,
enlightened people are taking charge of the health of
their arteries. They are eating better, exercising regu-
larly, and undergoing regular blood testing to identify
the specic drugs, hormones, and dietary supplements
they need to reduce their atherosclerotic risk factors.
The emphasis in treating aging humans with pre-
existing arterial disease is that all risk factors should be
controlled if there is to be an opportunity to reverse the
occlusion of vital arteries. When only a few atherogenic
factors like elevated LDL are lowered, disease progres-
sion is virtually inevitable, albeit at a slower rate.
Summary
At least one of every two Americans over the age of
65 has atherosclerosis.
1
A number of biochemical fac-
tors in the blood can affect the development of athero-
sclerosis such as elevated LDL cholesterol, low HDL
cholesterol, and elevated glucose, homocysteine or
brinogen to name a few. Atherosclerosis begins with
changes in endothelial cell function that cause white
blood cells moving through the blood to stick to the
endothelium (inner arterial wall) instead of owing
by normally. The endothelium then becomes weak-
ened. This allows blood cells and toxic substances
circulating in the blood to pass through the endothe-
lium and enter the arterys sub-endothelial compart-
ment. Lipid or fat-like substances such as LDL and
triglycerides in the blood then accumulate in this area.
Pathway to the
Development of
Deadly Arterial Plaque
At least one of every two Americans over

the age of 65 has atherosclerosis.
Life Extension has identified 17 major risk

factors for atherosclerosis.
Atherosclerosis begins with changes in

endothelial cell function that cause white
blood cells and lipids moving through the
blood to stick to the endothelium (inner
arterial wall) instead of flowing by normally.
The lipids that accumulate in the broken

endothelium become oxidized, causing the
smooth muscle cells to try to repair the
damaged endothelium.
Immune cells called macrophages then

invade the damaged arterial area to digest
the fat.
Smooth muscle cells try to curtail the injury

to the endothelium by producing collagen,
which forms a cap over the injury site.
Fat-laden white blood cells and smooth

muscle cells become foam cells which
provoke a chronic inflammatory attack by
various immune components.
This complex array of foam cells, calcification,

and lipid accumulation is called an athero-
sclerotic plaque.
Immune cells called macrophages then invade the
damaged arterial area to digest the fat. But smooth
muscle cells that have migrated to the area have
already changed their nature to scavenge fat. These
fat-laden white blood cells and smooth muscle cells are
called foam cells, and provoke a chronic inamma-
tory attack by various immune components. Smooth
muscle cells try to curtail the injury to the endothe-
lium by producing collagen, which forms a cap over
the injury site. Calcium then accumulates over the
injury site to form a material resembling bone.
This complex array of foam cells, calcication,
and lipid accumulation is called an atherosclerotic
plaque. This plaque can become unstable resulting
in an increased risk of rupture and clot formation.
Alternatively, the plaque can continue to grow to a size
so large that it impedes or completely blocks blood
ow. Either path can lead to a potentially life-threat-
ening stroke or heart attack.


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41. Howes PS, Zacharski LR, Sullivan J, Chow B. Role of stored iron
in atherosclerosis. J Vasc Nurs. 2000 Dec;18(4):109-14; quiz 115-6.
42. Kraml P, Potockova J, Koprivova H, et al. Ferritin, oxida-
tive stress and coronary atherosclerosis. Vnitr Lek. 2004
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43. Minqin R, Watt F, Huat BT, Halliwell B. Correlation of iron and
zinc levels with lesion depth in newly formed atherosclerotic le-
sions. Free Radic Biol Med. 2003 Mar 15;34(6):746-52.
44. Montalescot G, Ankri A, Chadefaux-Vekemans B, et al. Plasma
homocysteine and the extent of atherosclerosis in patients with
coronary artery disease. Int J Cardiol. 1997 Aug 8;60(3):295-300.
45. Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study
of plasma homocysteine and risk of myocardial infarction in US
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46. Verhoef P, Stampfer MJ, Buring JE, et al. Homocysteine metabo-
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47. Robinson K, Mayer EL, Miller DP, et al. Hyperhomocysteinemia
and low pyridoxal phosphate. Common and independent revers-
ible risk factors for coronary artery disease. Circulation. 1995
Nov 15;92(10):2825-30.
48. Arnesen E, Refsum H, Bonaa KH, Ueland PM, Forde OH,
Nordrehaug JE. Serum total homocysteine and coronary heart
disease. Int J Epidemiol. 1995 Aug;24(4):704-9.
49. Aronow WS, Ahn C. Association between plasma homocysteine
and coronary artery disease in older persons. Am J Cardiol. 1997
Nov 1;80(9):1216-8.
50. Berwanger CS, Jeremy JY, Stansby G. Homocysteine and vascu-
lar disease. Br J Surg. 1995 Jun;82(6):726-31.
51. Bostom AG, Rosenberg IH, Silbershatz H, et al. Nonfasting
plasma total homocysteine levels and stroke incidence in elderly
persons: the Framingham Study. Ann Intern Med. 1999 Sep
7;131(5):352-5.
52. Bots ML, Launer LJ, Lindemans J, Hofman A, Grobbee DE.
Homocysteine, atherosclerosis and prevalent cardiovascular
disease in the elderly: The Rotterdam Study. J Intern Med. 1997
Oct;242(4):339-47.
53. Maresca G, Di Blasio A, Marchioli R, Di Minno G. Measuring
plasma brinogen to predict stroke and myocardial infarction:
an update. Arterioscler Thromb Vasc Biol. 1999 Jun;19(6):
1368-77.
54. Acevedo M, Foody JM, Pearce GL, Sprecher DL. Fibrinogen:
associations with cardiovascular events in an outpatient clinic.
Am Heart J. 2002 Feb;143(2):277-82.
55. Thompson SG, Kienast J, Pyke SD, Haverkate F, van de Loo JC.
Hemostatic factors and the risk of myocardial infarction or sud-
den death in patients with angina pectoris. European Concerted
Action on Thrombosis and Disabilities Angina Pectoris Study
Group. N Engl J Med. 1995 Mar 9;332(10):635-41.
56. Jarosz A, Nowicka G. C-reactive protein and homocysteine as
risk factors of atherosclerosis. Przegl Lek. 2008 65(6):268-72.
57. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive
protein and other markers of inammation in the prediction
of cardiovascular disease in women. N Engl J Med. 2000 Mar
23;342(12):836-43.
58. Kuller LH, Tracy RP, Shaten J, Meilahn EN. Relation of C-re-
active protein and coronary heart disease in the MRFIT nested
case-control study. Multiple Risk Factor Intervention Trial. Am J
Epidemiol. 1996 Sep 15;144(6):537-47.
59. Mendall MA, Strachan DP, Butland BK, et al. C-reactive protein:
relation to total mortality, cardiovascular mortality and cardio-
vascular risk factors in men. Eur Heart J. 2000 Oct;21(19):
1584-90.
60. Pasceri V, Willerson JT, Yeh ET. Direct proinammatory effect of
C-reactive protein on human endothelial cells. Circulation. 2000
Oct 31;102(18):2165-8.
61. Ridker PM, Buring JE, Shih J, Matias M, Hennekens CH. Pro-
spective study of C- reactive protein and the risk of future car-
diovascular events among apparently healthy women. Circula-
tion. 1998 Aug 25;98(8):731-3.
62. Auer J, Berent R, Lassnig E, Eber B. C- reactive protein and
coronary artery disease. Jpn Heart J. 2002 Nov;43(6):607-19.
Back in 1983, Life Extension was the frst to introduce CoQ10 as a
proven method to enhance mitochondrial energy production.
CoQ10 has since gained universal recognition for its role in supporting
cellular performance throughout the body.
1-6
In an unprecedented breakthrough, a compound called PQQ (pyrrolo-
quinoline quinone) has been shown to support mitochondrial biogen-
esisthe spontaneous generation of new mitochondria in aging cells.
7
PQQ is available as a low-cost dietary supplement.
Mitochondria are cellular energy generators that supply virtually all the power your
body requires for a healthy life span. An abundance of published studies underscores
the critical importance of the mitochondria to overall health, especially as we age.
8-14

Energy-intensive organs like the heart and brain are dense with mitochondria.
Until recently, the only natural ways for aging individuals to increase the number of
mitochondria in their bodies were long-term calorie restriction or exhaustive physical
activitywhich are difcult or impractical for most people to implement.
PQQ ofers a viable alternative.
Critical Importance of Mitochondria
Item #01647

PQQ
PROMOTES
Mitochondrial Biogenesis
Vital Protection for
the Aging Heart and Brain
PQQ is an essential nutrient, meaning your body
cannot make it on its own. A growing body of research
indicates that PQQs unique nutritional profle supports
heart health and cognitive functionalone and in
combination with CoQ10.
17,18
This comes as no surprise,
given how much energy these vital organs need.
Research shows that PQQ supports heart cell
function in the presence of free radicals and promotes
blood fow in heart muscle.
19
When taken in combination with CoQ10, just 20 mg
per day of PQQ has been shown to promote memory,
attention, and cognition in maturing individuals.
20
A Breakthrough Weapon
in the Battle Against Aging
Life Extension has identifed a purifed, highly
potent form of PQQ from Japan that is produced
through a unique fermentation process. The result is
the highest quality PQQ available on the market today
called BioPQQ.
A bottle containing 30 20 mg vegetarian capsules
of PQQ Caps with BioPQQ retails for $40. If a
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The recommended daily dose for PQQ is 20 mg.
Those taking Mitochondrial Energy Optimizer or
Mitochondria Basics only require an additional 10 mg
of PQQ since these formulas already provide 10 mg of
PQQ. The retail price for 30 10 mg PQQ caps is $24.
If a member buys four bottles, the price is reduced to
only $16.50 per bottle. (Item #01500)
BioPQQ is a trademark of MGC (Japan).
The Ultimate
Cell Rejuvenator
The enormous amount of energy generated within
the mitochondria exposes them to constant free radical
attack. The resulting mitochondrial decay is a hallmark
of aging.
PQQ protects and augments delicate mitochondrial
structures to promote youthful cellular function in three
distinct ways:
r
Antioxidant power. Like CoQ10, PQQ is a
highly potent antioxidant. Its extraordinary
molecular stability enables it to facilitate
thousands of biochemical reactions in the
mitochondria, without breaking down, for
maximum antioxidant and bioenergetic
support.
15

r
Favorably modulates gene expression.
PQQ activates genes that promote formation
of new mitochondria
7
and benefcially
interacts with genes directly involved in
mitochondrial health. These same genes also
support healthy body weight, normal fat
and sugar metabolism, and youthful
cellular proliferation.
16
r
Mitochondrial defense. Mitochondria
possess their own DNA, distinct from the DNA
contained in the nucleus. Unfortunately, com-
pared to nuclear DNA, mitochondrial DNA is
relatively unprotected. PQQs antioxidant
potency and favorable gene expression
profle act to support mitochondrial defense.
To order PQQ Caps with BioPQQ

standalone or any other PQQ-containing
formula call 1-800-544-4440 or visit
References
1. Mitochondrion. 2007 Jun;7 Suppl:S103-11.
2. Mech Ageing Dev. 1978 Mar;7(3):189-97.
3. Arch Biochem Biophys. 1992 Jun;295(2):230-4.
4. Lipids. 1989 Jul;24(7):579-84.
5. Biogerontology. 2002;3(1-2):37-40.
6. Exp Gerontol. 2004 Feb;39(2):189-94.
7. J Biol Chem. 2010 Jan 1;285:142-52.
8. Biochimie. 1999 Dec;81(12):1131-2.
9. Lancet. 1989 Mar 25;1(8639):642-5.
10. Curr Opin Clin Nutr Metab Care. 2010 Jul 7.
11. Age (Dordr). 2010 Mar 20.
12. Ageing Res Rev. 2010 Jun 25.
13. Cell Mol Life Sci. 2010 Jun 25.
14. Zhonghua Yi Xue Za Zhi (Taipei). 2001
May;64(5):259-70.
15. J Nutr. 2000 Apr;130(4):719-27.
16. Entrez Gene: PARGC1A peroxisome proliferator-
activated receptor gamma, coactivator 1 alpha
[Homo sapiens] GeneID: 10891.
17. Cardiovasc Drugs Ther. 2004 Nov;18(6):421-31.
18. J Cardiovasc Pharmacol Ther. 2006 Jun;11(2):119-28.
19. Biochem Biophys Res Commun. 2007 Nov
16;363(2):257-62.
20. FOOD Style. 2009;21:13(7)50-3. [Tokyo].
A
G
I
N
G
BY GARY GOLDFADEN, MD, AND ROBERT GOLDFADEN
Revitalize Your
Aging Neck
Most skin care regimens are formulated only for fighting the fine
lines and wrinkles on the face. Your neck, however, is a dead give-
away of age.
The thin skin on your neck is especially prone to sagging and
wrinklesand often well before your face shows your age. Youve
seen many women on TV who have had face lifts but take one look
at their neck and you see the visible effects of aging.
In fact, your neck and upper chest/shoulder/torso area (collec-
tively referred to as the dcollet) may be one of the most underap-
preciated features of a youthful appearance.
For years, maturing individuals seeking to rejuvenate their necks
resorted to potentially dangerous cosmetic procedures such as
peels, laser resurfacing, Botox injections, and surgery.
1

But there are safer, effective, more natural approaches to fight-
ing the visible signs of an aging neck. Advances in research have
led to the discovery of compounds that offer novel approachs to
reversing the visible signs of aging. These compounds have been
shown to act as chemical messengers between the dermal layers
of the skin, thus allowing efficient communication to protect, repair,
and strengthen the skin from the inside out.
In this article, you will learn about agents that help restore and
retain a youthful-appearing neck and dcollet. >
APRIL 2013 | LIFE EXTENSION | 87 APR APR APPR PR R APR RRIL IL IL IIII 201 2013 3 | LLLLIFE FE IFEE IFE IFE FEE EX EXTEN TENNNNSI SIO SI SIO IOOO I NNNNNNN ||||| 8888888888888888888777777777
REVITALIZE YOUR AGING NECK
Maintaining Skin Cohesion
The dermo-epidermal junction is an area that
connects the epidermal skin layer with the dermal layer
beneath it. Acting as a communication center between
the two skin layers, it maintains skin cohesion and
distributes essential nutrients to the epidermis for
healthy skin.
2
As we age, the dermo-epidermal junction of the
skin begins to atten out, diminishing the contact
between the epidermis and dermis.
3
As a result, the
skin begins to lose its elasticity and rmness. This is
reected in the skin of the neck with the development
of wrinkles and sagging.
Fortunately, there is a way to rebuild this vital con-
nection between the layers of aging skin. The pep-
tide compound hexapeptide-10 has been shown to
stimulate the formation of laminin-5, _6-integrin, and
hemidesmosomes,
4
vital building blocks of the dermo-
epidermal junction that allow it to reconstruct con-
nectivity between epidermal and dermal cells. This
reinforces the skins tightness and promotes more
elasticity.
In one study, scientists tested the effects of hexa-
peptide-10 on several skin parameters in healthy vol-
unteers for 60 days. The results revealed a 9% boost
in elasticity and a 53% improvement in skin compact-
ness. Skin tone was also enhanced by 46%.
4
Support Vital Skin Structures
Your skin has a network of bers that work to
keep it rm and taut. Collagen type I provides
mechanical strength to the structure, while elastin is
responsible for skins resilience and its ability to recoil
back into position. These elements are continuously
breaking down and being regenerated. However, fac-
tors such as excessive sun exposure, smoking, inam-
mation, and air pollution cause collagen type I and
elastin to break down at a faster pace than theyre
being regenerated.
5
Over time, this accelerates aging,
which manifests itself as wrinkles and loose skin.
Theres one notable ingredient that has been shown
to both slow the breakdown and increase the formation
of these vital skin structures. An in vitro study showed
that the compound acetyl-dipeptide-13 diphenylgly-
cine protected elastin from destruction by decreasing
the activity of elastase by 23%.
6
Additionally, when the
cells that make collagen were exposed to acetyl-dipep-
tide-13 diphenylglycine, they experienced an astonish-
ing 99% increase in collagen type I formation.
6
In a human study, participants who used a topi-
cal application of acetyl-dipeptide-13 for eight weeks
improved their overall skin elasticity by 14% and
tightness by 16%.
6
Fight Free Radical Damage
Free radicals wreak havoc on the skins integrity
and structure, especially in the thin skin of the neck.
Thats why a broad spectrum antioxidant defense is
a cornerstone of any skin care regimen. And when it
comes to antioxidant power, you cant beat the goji
berry.
Goji berries boast an extremely high rating on
the ORAC scale, an indicator of antioxidant potency.
7

Theyve been shown to boost human blood antioxi-
dant activity by up to 57%.
8
A 2004 study showed that
goji berries inhibited the formation of free radicals by
an incredible 82%, further conrming their outstand-
ing antioxidant properties.
9
Goji berries have a tremendous amount of nutri-
ents that nurture and protect the skin. They contain
more collagen-building vitamin C than an orange,
along with vitamin E to reduce wrinkles and seal in
moisture.
10
Goji berries also contain bioactive polysaccharides,
complex carbohydrates that repair and rejuvenate
the skin of the neck by suppressing the elevation of
enzymes involved in collagen destruction.
11
Goji berries
Halt Collage Destruction
The Indian gooseberry (Phyllanthus emblica)
has been celebrated for centuries in India for its high
antioxidant capacity and potent anti-inammatory
effects.
12
These attributes have sparked interest in the
fruits potential as a topical ingredient in skin care
preparations. And as it turns out, Indian gooseberry
has the potential to protect against one of the chief
causes of premature aging: ultraviolet (UV) damage.
Sun damaged skin causes an internal breakdown
of collagen that contributes to ne lines, wrinkles,
age spots, and uneven skin tone. When scientists
investigated the impact of the Indian gooseberry on
UV radiated human skin broblasts, they found that
the fruit extract was effective in protecting against
UV damage by inhibiting the expression of matrix
metalloproteinases in the specialized skin cells.
13
The powerful berry has been found to offer other
benets to the aging skin, including boosting the
synthesis of collagen type I,
14
halting the collagen-
destructive ability of collagenase,
17
and promoting
dermal wound healing.
15
Keep Skin Hydrated
In order for skin to stay healthy and young look-
ing, it must be properly hydrated and nourished.
Hyaluronic acid plays a vital role in creating an
environment in which skin cells obtain proper hydra-
tion and nourishment. Along with water and protein
complexes, hyaluronic acid acts as a ller in between
the spaces of a ber network consisting mostly of col-
lagen and elastin beneath the surface of your skin.
16
The compounds main function is to attract and
retain water, leading the skin to hold moisture and in
return lessens the visibility of ne lines. Whats more,
hyaluronic acid is responsible for transporting essen-
tial nutrients to the skin cells, supplying them with
the weapons required to rejuvenate themselves.
17
Restoring a Youthful-
Appearing Neck and
Dcollet
The skin of the neck and dcollet is

one of the most important features
of a youthful appearance, but is often
the most neglected area in a skin care
regimen.
The thin skin of the neck and dcollet

makes it prone to damage by external
factors such as UV damage and chemi-
cal pollutants, resulting in the formation
of wrinkles, age spots, fine lines, and
uneven skin tone.
Topical ingredients, including hexapep-

itde-10, acetyl-dipeptide-13, goji berries,
Indian gooseberry, and hylauronic acid
are safe and effective weapons in pro-
tecting, repairing and strengthening your
skin, revealing a more youthful-looking
neck and dcollet.
Over time, hyaluronic acid synthesis decreases
due to the unfavorable effects of UV radiation and
free radical damage, severely depleting its reserves.
18
Replenishing hylauronic acid can nourish your aging
neck, providing increased skin hydration and rmer
skin tone.
Summary
A youthful-looking neck and dcollet is the hall-
mark of a youthful appearance. Novel agents, includ-
ing hexapepitde-10, acetyl-dipeptide-13, goji berry,
Indian gooseberry, and hylauronic acid work together
to repair the dermo-epidermal junction, strengthen the
underlying skin structure, and increase hydration to
help restore a youthful-appearing neck and dcollet.


References
1. Caplin DA, Perlyn CA. Rejuvenation of the aging neck: current
principles, techniques, and newer modications. Facial Plast Surg
Clin North Am. 2009 Nov;17(4):589-601.
2. Le Varlet B, Chaudagne C, Saunois A, et al. Age-related functional
and structural changes in human dermo-epidermal junction com-
ponents. J Investig Dermatol Symp Proc. 1998 Aug;3(2):172-9.
3. Lavker RM, Zheng PS, Dong G. Morphology of aged skin. Clin
Geriatr Med. 1989 Feb;5(1):53-67.
4. Available at: http://www.lotioncrafter.com/reference/tech_data_ser-
ilesine_solution.pdf. Accessed August 17, 2012.
5. Gogly B, Ferre FC, Cheri H, Naveau A, Fournier BP. Inhibition
of elastin and collagen networks degradation in human skin by
gingival broblast. In vitro, ex vivo and in vivo studies. Journal
of Cosmetics, Dermatological Sciences and Applications. 2011
March;1(1):4-14.
6. Available at: http://www.lotioncrafter.com/reference/tech_data_
relistase.pdf. Accessed August 17, 2012.
7. Available at: http://www.oracvalues.com/. Accessed December 18,
2013.
8. Bucheli P, Vidal K, Shen L, et al. Goji berry effects on macular
characteristics and plasma antioxidant levels. Optom Vis Sci. 2011
Feb;88(2):257-62.
9. Wu SJ, Ng LT, Lin CC. Antioxidant activities of some common in-
gredients of traditional chinese medicine, Angelica sinensis, Lycium
barbarum and Poria cocos. Phytother Res. 2004 Dec;18(12):1008-12.
10. Potterat O. Goji (Lycium barbarum and L. chinense): Phytochemis-
try, pharmacology and safety in the perspective of traditional uses
and recent popularity. Planta Med. 2010 Jan;76(1):7-19.
11. H. Zhaoa, A. Alexeeva, E. Changa,b, G. Greenburgc, K.
Bojanowskia, Lycium barbarum glycoconjugates: effect on
human skin and cultured dermal broblasts. Phytomedicine. 2005
Jan;12(1-2):131-7.
12. Krishnaveni M, Mirunalini S. Therapeutic potential of Phyllanthus
emblica (amla): the ayurvedic wonder. J Basic Clin Physiol Pharma-
col. 2010;21(1):93-105.
13. Adil MD, Kaiser P, Satti NK, et al. Effect of Emblica offcinalis (fruit)
against UVB-induced photo-aging in human skin broblasts. J Eth-
nopharmacol. 2010 Oct 28;132(1):109-14.
14. Chanvorachote P, Pongrakhananon V, Luanpitpong S, et al. Type
1 pro-collagen promoting and anti-collagenase activites of Phyl-
lanthus emblica extract in mouse broblasts. J Cosmet Sci. 2009
Jul-Aug;60(4):395-403.
15. Sumitra M, Manikandan P, Gayathri VS, Mahendran P, Suguna L.
Emblica ofcinalis exerts wound healing action through up-regula-
tion of collagen and extracellular signal-regulated kinases (ERK1/2).
Wound Repair Regen. 2009 Jan-Feb;17(1):99-107.
16. Tzellos TG, Klagas I, Vahtsevanos K. Extrinsic ageing in the
human skin is associated with alterations in the expression of
hyaluronic acid and its metabolizing enzymes. Exp Dermatol. 2009
Dec;18(12):1028-35.
17. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair.
Wound Repair Regen. 1999 Mar-Apr;7(2):79-89.
18. Dai G, Freudenberger T, Zipper P, et al. Chronic ultraviolet B irradia-
tion causes loss of hyaluronic acid from mouse dermis because of
down-regulation of hyaluronic acid synthases. Am J Pathol. 2007
Nov;171(5):1451-61.
5 Ingredients for Firmer,
Younger Skin
Hexapeptide-10 reconstructs the connectivity
of the dermo-epidermal junction, thereby rein-
forcing the skins elasticity and firmness.
AcetyI-dipeptide-13 diphenyIgIycine
improves skins tightness by halting the break-
down of elastin and stimulating the synthesis of
collagen type I synthesis.
Goji berries have unparalleled antioxidant
power that protects the skins integrity and
internal structure from free radical damage.
Indian gooseberry defends against UV dam-
age that leads to an early loss of elasticity.
HyaIuronic acid provides increased skin
hydration and firmer skin tone.
Indian gooseberry
The Moisturizing Pill the Japanese
Have Enjoyed for a Decade!
Lipowheat

ceramides have been available to
Japanese women as a functional food since 2000.
5

The hydrating action of Lipowheat

ceramides have
proven efective in clinical trials.
To take one example, after just three months ingesting
200 mg per day of Lipowheat, a group of people
reported dramatic improvement in the look and feel of
their skin. These results were verifed by electrochemical
analysis showing that 95% of participants exhibited
improved skin hydration. Even better, all subjects who at
the onset of the study experienced chronic itching
reported sharply decreased itching or complete elimina-
tion of the problem by the end of the study!
5
Aging Americans can now ofset the visible impact
of the gradual decline in their ability to produce enough
ceramides by using Skin Restoring Phytoceramides
with Lipowheat.
One bottle containing 30 350 mg vegetarian liquid
capsules of Skin Restoring Phytoceramides with
Lipowheat

retails for $25. If a member buys four
bottles, the price is reduced to $17.25.
Contains wheat.
Lipowheat
is a trademark of LAVIPHARM Group of Companies.

Item # 01596
To order Skin Restoring Phytoceramides with Lipowheat
Your Skins Internal
Moisturizer
Ceramides are essential for preserving healthy-looking
skin.
1,2
Thats why theyre included in so many anti-aging
face creams.
Your bodys production of ceramides declines with
age.
3
Thats bad news, since ceramides make up 35-40%
of the binding matrix that maintains moisture balance
and protects the skins surface.
4
Its therefore critical that
ceramides lost to aging are replaced.
Restore Ceramides Naturally from Within!
The ceramides that young skin naturally produces
to retain its supple appearance are identical to those
present in wheat!
Wheat-derived oils have been used topically for
centuries as a natural moisturizer. But you cant get
enough ceramides from topically applied wheat oil to
have a long-term impact on your skins appearance. And
they dont appear in sufcient concentration in your diet.
Thats why Life Extension brought together these
skin-nourishing oils in a concentrated oral formula called
Skin Restoring Phytoceramides with Lipowheat.
Lipowheat

is a proprietary ceramide blend that
ofers nutritional support for aging skin to complement
the topical products you may already be using.
References
1. Biophys Chem. 2010 Aug;150(1-3):144-56.
2. Chemistry and Physics of Lipids. Apr
2007;146(2):67-75.
3. Baran R, Maibach H, eds. Textbook of Cosmetic
Dermatology. 3
rd
ed. Taylor & Francis;2005:177.
4. Int J Cosmet Sci. 2010 Jul 14. .
5. www.fda.gov/ohrms/dockets/dockets/95s0316/
95s-0316-rpt0275-04-Udell-vol211.pdf
Accessed August 10, 2010.
6. J Med Esth et Chir Derm. 2007 Dec; 34(136):239-42.
RejuveneX

Factor provides 28 active ingredients in a deep-penetrating serum.
To get these skin protecting and rejuvenating compounds elsewhere, youd
need to layer on a dozen expensive creamseach providing only 2 or 3 of these
active ingredients.
The good news is thatfor a fraction of the costRejuveneX Factor Firming
Serum delivers optimal dosages of the full range of clinically proven technologies
to promote the appearance of youthful, frmer, and more vibrant skin.
SERUM VS. CREAM
RejuveneX Factor is a seruma more concentrated format that is thinner than
a cream and ensures superior absorption of its 28 skin enhancing compounds.
RejuveneX Factor Firming Serum comes in an airless pump to protect the
integrity of the bioactives, and utilizes a patented deep-layer delivery system that
provides sustained release for 6 to 8 hours!
RejuveneX Factor Firming Serum is uniquely free of paraben, irritants,
estrogenic chemicals, mineral oil, and synthetic fragrances.
HUGE SAVINGS
A 1.7 oz bottle of RejuveneX Factor Firming Serum retails for $65. If a member
buys two bottles, the price is reduced to $38 a bottle. If six bottles are purchased,
the price is only $28.89 a bottle.
To order Rejuvenex
Factor Firming Serum call 1-800-544-4440 or visit www.LifeExtension.com

QuSome and Advanced Efficacy are registered trademarks of BioZone Laboratories, Inc. US Patent No. 6.610.322, 6.958.160, 7,150.883, 6.998.421. HylasomeTM is a trademark of Genzyme Corporation, the use of which is licensed to HylaMed Research Inc.
Worlds Most Comprehensive
ANTI-AGING SKIN SERUM
Taurine: Helps neutralize free radicals and inhibit
premature aging of the skin.

Salicylic acid: Supports production of new skin cells.

Ceramide-2: Promotes the shedding of old skin cells
and helps retain moisture.

Thioctic acid (alpha lipoic acid): Supports the skins
normal antioxidant protection.

Lactic acid: Helps the body shed dead skin cells.

Vitamin C (ascorbyl phosphate): Helps strengthen
the skin barrier and promote collagen production.

Hylasome EG10 (hyaluronate crosspolymer):
Holds more moisture in skin cells and targets free
radicals.

Glycerin: Minimizes the appearance of wrinkles by
supporting elasticity and moisture retention.

Avobenzone: Helps protect the skin from the visible
efects of sunlight exposure.

Glycine soja (soybean) oil: Promotes collagen
production and skin elasticity
11
and supports UV
defense.

Panthenol: Potent support for skins normal
moisturizing ability.

DMAE (dimethylaminoethanol): Helps smoothe
and frm skin.

Botanimoist AMS (Pyrus malus): Helps boost
hydration of skin cells.

Botanistat PF-64: Helps preserves serum against
environmental toxins (avoiding the preservative
paraben).

Pomegranate (Punica granatum) extract: Reduces
visible signs of aging by promoting skin cell turnover.
Green tea (Camellia sinensis) extract: Provides
antioxidant support to help prevent signs of premature
aging.

White tea (Camellia sinensis) extract: Protects the skin
from visible signs of UV exposure.

QuSome delivery system: Breakthrough delivery
system delivers maximum active ingredients directly
into the skin.

Matrixyl synthe6
TM
: Helps minimize the appearance
of fne lines and wrinkles.

Vegetal Filling Spheres
TM
: Expand with moisture to
allow plumping of wrinkles.

PolyP (sodium polyphosphate): Supports production
of collagen.

Pichia-fermented Resveratrol extract: Increases
hydration, diminishing the appearance of lines.

Tocopherol (vitamin E): Superior penetration helps
reduce the appearance of fne lines and wrinkles.

Tocopheryl acetate (vitamin E): Promotes skin repair
and natural defenses against premature skin aging.

Beta-glucan: Supports collagen formation, defense
against UV exposure,

and healthy skin.
RNA: Promotes production and turnover of new skin
cells.

Sodium PCA: Helps skin stay moisturized, soft, supple,
and frm, and helps prevent breakouts.

Hydroxydecyl ubiquinone (CoQ10): Supports collagen
and elastin for smoother, younger-looking skin.

ITEM# 01621
Rejuvenex
Factor Firming Serum Provides 28 Active Compounds:

A line of skin care products developed by
renowned dermatologist Gary Goldfaden, MD
Developed Exclusively for Life Extension
If youre not targeting the thin skin of your neck area, then
youre overlooking one of the most obvious signs of aging.
Your neck and upper chest/shoulder/torso area is a dead
giveaway of your age because its thin skin is especially prone
to sagging and wrinkles.
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References
1. Available at: http://www.lotioncrafter.com/reference/
tech_data_serilesine_solution.pdf.
2. Available at: http://www.lotioncrafter.com/reference/
tech_data_relistase.pdf.
3. J Ethnopharmacol. 2007 May 22;111(3):504-11.
4. Phytother Res. 2004 Dec;18(12):1008-12.
5. J Ethnopharmacol. 2010 Oct 28;132(1):109-14.
6. Am J Pathol. 2007 Nov;171(5):1451-61.
7. Wound Repair Regen. 1999 Mar-Apr;7(2):79-89.
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References
1. Paper: Making Sense of Digestive Enzymes: ProThera, Inc.;2008.
2. Altern Med Rev. 2004 Mar;9(1):63-9.
3. Available at: http://www.us.elsevierhealth.com/media/us/
samplechapters/9781437709599/Sample-Chapter-04.pdf.
Accessed October 3, 2012.
4. J Int Soc Sports Nutr. 2008 Jul 24;5:10.
5. Available at: http://chemistry-today.teknoscienze.com/pdf/
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AUTHOR INTERVIEW
Power Foods
for the Brain
An Effective 3-Step Plan to
Protect Your Mind and
Strengthen Your Memory
AUTHOR INTERVIEW
Losing memory and brainpower is not
just a part of life that everyone must
endure as part of the aging process. Just
as diet, environment, and lifestyle play
an integral role in the health of the body,
the same goes for the brain. Research-
ers from around the world have uncovered
specific nutrients that either endanger or
offer protection to the brain. New imag-
ing techniques have been developed that
allow scientists to study the brain as a liv-
ing systemto learn how it functions and
how the brain is affected by time, nutri-
tion, and lifestyle. Cutting edge test-
ing has begun to offer clues as to who is
most at risk for cognitive disease as time
passes. As this body of research has
amassed, it has become clear that spe-
cific foods, eating behaviors, lifestyle, and
environmental factors can have a pow-
erful effect on the function of the brain.
The following is an exclusive Life Exten-
sion
interview about Dr. Neal Barnards

new book, Power Foods for the BrainAn
Effective 3-Step Plan to Protect Your Mind
and Strengthen Your Memory, which uni-
fies this growing body of data and offers a
groundbreaking 3-step plan to safeguard
your brain function now and in the future.

LE: Early in your book, you explain the
concept of building a shield for your
brain and you mention it when talking
AUTHOR INTERVIEW
LE: What are rusty brain cells
and how did you come up with that
description?
NB: If you were to leave a cast
iron pan on your backyard picnic
table for a day or two and a bit of
rain happened to fall, what hap-
pens? Iron rusts. Thats oxidation.
And iron oxidizes in your body,
too. When that oxidation process
occurs, it tends to produce free
radicals. A free radical starts out
as an innocent molecule. It could
be oxygenoxygen that your body
needs for health. But if the oxy-
gen molecule loses an electron or
an electron gets into an unstable
orbit, it becomes a free radical.
Free radicals form in your blood-
stream, in your cells, and even in
your brain. And each one is like a
spark, burning holes in your brain.
As iron oxidizes, it encourages free
radicals to form. Most Americans
get too much iron, because of the
meaty diets that are part of the
culture. The iron in meat is called
heme iron, and it tends to be a bit
too absorbable; it can overload
you with iron. The very best foods
for iron are our neglected friends,
beans and green leafy vegetables.
These foods have a special form of
iron called non-heme iron, which
is more absorbable when your
body needs more and less absorb-
able when your body has enough
iron already. They help prevent the
lows and highs in iron that can be
bad for your brain.
LE: While were talking about
this, are these metals lurking in
everyday use?
NB: Well, lets start in the
kitchen. Is there a cast-iron pan
on your stove? How about copper
pipes. They became popular in the
early part of the 20
th
century, and
if your drinking water has been
sitting in copper pipes overnight,
there is copper in the water youre
drinking. Red meats tend to be
high in metals, especially iron. And
the mother lode of copper is a plate
of liver. It might surprise you that
one of the biggest sources of met-
als is a typical multiple vitamin.
Now, the vitamins themselves are
ne. But in many formulations,
manufacturers add iron that you
may not need. It pays to look for
a vitamin without added met-
als. Beans and greens, along with
fruits and grains, give you the iron
and copper you need, without the
risk of overdoing it. When water
passes through a municipal treat-
ment plant, aluminum is typically
added as part of the process of
making impurities settle out. And
unfortunately, traces of aluminum
remain. You turn on your tap and
out comes the water mixed with
aluminum. Aluminum pots and
pans can leak some aluminum into
foods. The baking powder used in
the pancakes you may have had for
breakfast probably has aluminum
in it, unless you used aluminum-
free baking powder, which is avail-
able at any grocery store. Frozen
pizzas may have aluminum in the
cheese or the crust. Those little
single-serve salt and sugar pack-
ets often have aluminum to keep
the salt or sugar from caking. If
you buy antacids, read the labels.
Some have aluminum; others are
aluminum-free.
Editors Note: There is a debate as to
whether people should take a small
amount of copper in their multi-nutrient
formulas. Deciency of copper can cre-
ate serious problems, including loss of
communication (synaptic transmission)
between brain cells. Once copper is used
to facilitate synaptic transmission it can
turn into a neurotoxin that the brain must
buffer against. Protection against copper
toxicity to brain cells can be obtained by
supplementing with 1,000 milligrams a
day of carnosine.*
* Available at: http://www.lef.org/magazine/
mag2001/jan2001_report_carnosine_4.html.
Accessed January 29, 2013.
about protecting your brain from
toxic metals. What metals would
people be surprised are actually
found in the brain and what nega-
tive impact do they have?
NB: Many people experience
memory lapses from time to time.
And memory problems grow more
severe as the years catch up with
us. Alzheimers disease attacks half
of Americans by age 85. It is nan-
cially devastating, of course, but the
personal costs are incalculable. We
need to be able to shield ourselves
from the threats to brain health.
These include toxic metals, as well
as unhealthy fats, certain prescrip-
tion drugs and their side effects, as
well as many other things. Metals
are particularly important. When
researchers study individuals who
have died with Alzheimers disease,
their brains contain beta-amyloid
plaques. Under the microscope,
they look a bit like tiny meatballs
in between the brain cells. When
researchers tease these plaques
apart, they nd not only beta-amy-
loid protein, but also certain met-
als. Iron, for starters. Of course,
we need a certain amount of iron.
Traces of iron are part of the hemo-
globin molecules that your red
blood cells use to carry oxygen in
your bloodstream. If you didnt
have iron, you would be anemic.
But excess iron threatens brain
health. That is also true for copper.
Aluminum is also under suspicion.
Back in the 1980s, researchers in
England noticed that Alzheimers
disease cases tended to be clus-
tered in those counties that had
more aluminum in the drinking
water. They had as much as 50%
higher risk of Alzheimers com-
pared to the lower-aluminum
counties. Studies elsewhere had
similar ndings. This area remains
controversial, but while research-
ers ght it out, it makes sense to
protect yourself.
AUTHOR INTERVIEW
green leafy vegetables, surpris-
ingly enough. We dont think of
broccoli or other green vegetables
as having any fat. And they dont
have very muchnot nearly as
much as beef or chicken breast or
salmon. But about 8% of the calo-
ries in broccoli are from fat, and
proportionately, they are high in
ALA. The take-home message is
that there are traces of good fats,
not just in broccoli but in kale, col-
lards, and other green vegetables.
There is more of it in walnuts and
axseeds, and in certain oils, espe-
cially canola oil, and even supple-
ments that you can buy at the store.
If you include green vegetables
and nuts in your routine, youll get
good fats for your brain. Also, it
pays to avoid other fats, because
they can tie up the enzymes that
lengthen ALA to the other forms.
So overall, you want to reduce
your fat intake, especially the bad
fats, but you want to get traces of
good fats from healthy sources.
LE: At the beginning of Chapter
5 in your book, you list a few vita-
mins and nutrients that play crucial
roles in building a vitamin shield
for your brain. Can you name a few
and why theyre so vital?
NB: Vitamin E is a powerful
antioxidant. That means that it
knocks out free radicals. It is in
spinach, in mangoes, in sweet pota-
toes, and in much larger amounts
of nuts and seeds. It makes a real
difference. Earlier I mentioned the
Chicago Health and Aging Project,
which looked at how foods affect
the brain. In that study, those
who got more vitamin E had less
than half the risk of Alzheimers
disease, compared with people
who were missing vitamin E. So
vitamin E plays a huge role. The
bottom line is that iron and cop-
per make sparksfree radicals.
Vitamin E is the re extinguisher
that blows all those sparks away.
studied a group of 9,844 people,
measuring their cholesterol levels
in the 1960s and 1970s when their
average age was around 40. Then
three decades later, they looked to
see who developed memory prob-
lems. It turned out that the higher
the cholesterol, the higher the risk
of Alzheimers disease. But there
is more to it. Fatty diets and high
cholesterol levels seem to cause
the brain to produce more beta-
amyloid. A team of researchers
took blood samples immediately
after death from individuals who
had had Alzheimers disease, and
then at autopsy they looked inside
the brain. They found that the
higher the level of cholesterol in
the blood, the more beta-amyloid
was inside the brain. The best
advice for protecting your brain
not to mention your heart and
your health overall, is to avoid
animal products. I did not grow
up with a vegan diet, but having
seen its powernot to mention
how delightful the foods can be
Ive adopted an entirely vegan diet,
and I only wish Id done it earlier.
LE: You are quick to point
out that some fats are essential,
namely the omega-3 fat, alpha-lin-
olenic acid. Why is that so impor-
tant and how do they play a role in
brain function?
NB: Alpha-linolenic acid is one
of two essential fats. In our bod-
ies, it is lengthened to other fats
that are essential to brain func-
tion. The healthiest source is
LE: Turning our attention to the
American diet for a second, how do
saturated fats negatively affect the
brain?
NB: In 2003, researchers with
the Chicago Health and Aging
Project found that saturated fat
the kind of fat that predominates
in animal productsis linked to
Alzheimers disease. Some study
participants ate a lot of saturated
fatabout 25 grams a day. Others
ate only about half that amount,
about 13 grams per day. It turned
out those who got about 25 grams
of saturated fat each day had more
than 3 times the risk of develop-
ing Alzheimers disease, compared
with those who ate less bad fat.
If you add it up, it is easy to get to
the 25 grams of bad fat per day
that was a problem in the Chicago
study: a couple of eggs, one strip of
bacon, one chicken thigh (without
the skin), a glass of milk, a small
pizza. All together, thats more than
25 grams of saturated fat. Trans
fatspartially hydrogenated oils
are a problem, too.
LE: So why do these fats cause
problems for the brain?
NB: Well, weve known for a
long time that bad fats tend to
increase your cholesterol level.
And if you have too many cho-
lesterol particles owing through
your arteries, they can lead to
artery blockages, not just in the
heart, but in the arteries to the
brain, too. California researchers
AUTHOR INTERVIEW
LE: And nally, Power Foods for
the Brain is an outstanding resource
for anyone interested in improving
mental health through their diet.
If people followed your guidance,
could we prevent Alzheimers dis-
ease and other forms of dementia?
NB: Evidence suggests we could
cut the risk of these conditions dra-
matically. In the same way that the
previous generation learned how
to use foods to tackle heart disease
and reduce cancer risk, the current
generation is learning that foods
can protect the brain, too.
If you have any questions on the

scientific content of this article, please
call a Life Extension
Health Advisor
at 1-866-864-3027.
Dr. Neal Barnard is president of the
Physicians Committee for Responsible
Medicine, a faculty member of
the George Washington School of
Medicine, and the founding member
of the Whole Foods Medical Advisory
Board. He is a New York Times best-
selling author and a monthly columnist
for the Vegetarian Times. He is featured
in the new, nationally released docu-
mentary, Forks Over Knives, and has
previously appeared on Today, Good
Morning America, Ellen, and Dr. Oz.
For more information visit:
http://www.nealbarnard.org/.

To order Power Foods for the Brain,
call 1-800-544-4440 or visit
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avoid natural sugars or starches
the usual nave approach that has
gotten a lot of attention. Rather,
the answer is to avoid animal prod-
ucts and other fatty foods. As fat
enters the cells, it interferes with
insulins ability to work. So it pays
to emphasize vegetables, beans,
whole grains, and fruit, and skip
animal products and greasy foods
in general. Avoiding fats is a much
more powerful step than avoiding
healthful carbohydrates.
LE: How important is exercise to
maintaining a healthy brain? What
have studies shown?
NB: It protects the brain, just
as it protects the heart. At the
University of Illinois, researchers
asked 120 adults to take a brisk
walk for 10 minutes, 3 times a
week. And then they increased
the length of each walk to 15 min-
utes the next week, then to 20
minutes the following week, and
so on, until they got to about 40
minutes, three times a week. Over
time, this simple exercise program
actually reversed the age-related
shrinking of the brain that occurs
in most sedentary people. Memory
improved as well.
LE: Aside from supplements,
what are a few ways that people
can actually strengthen their
brains?
NB: These are the key steps:
1. Avoid bad fats. That means
saturated fat and trans fats.
2. Emphasize vegetables, fruits,
whole grains, and beans.
3. Take a vitamin B12 supplement
daily.
4. Be on the lookout for excess
iron, copper, and aluminum.
5. Get plenty of exercisephysical
and mental.
6. Get plenty of rest and sleep.
Three B-vitamins play key roles,
too. At the University of Oxford,
researchers tested folate, B6, and
B12 in a research study. Half the
participants got these vitamins,
while the other half got a dummy
pilla placebo. The people who
received the placebo had the usual
problems with memory as the years
went by. But those who got the three
B-vitamins did much better; they
generally preserved their memories
as the years went by. The research-
ers also did an MRI scan to actually
measure the brain, and found that
those who were getting a dummy
pill had continuing brain atrophy,
something that is often seen in
older people. They lost about 2.5%
of their brain volume per year. But
in the B-vitamin group, atrophy
was reduced to just 0.5% per year.
The vitamins work, we believe,
by knocking out a toxic chemical
called homocysteine, which can be
very rough on the brain. Your doc-
tor can check your homocysteine
level, and if youre high, these vita-
mins can remove it and that can
make a big difference. Folate is in
green leafy vegetables. Vitamin B6
is in beans and bananas, and many
other foods. Vitamin B12 is sup-
plemented in many foods such as
cereals. It is also in vitamin supple-
ments. These vitamins protect you.
LE: Since our diets inuence
more than one part of our bodies,
how does something as common
as excess blood sugar affect the
brain? And how important is man-
aging blood sugar for brain health
and what would be a solid blood
glucose management strategy?
NB: Some researchers have
begun to speak of a role of insu-
lin in memory problems, includ-
ing Alzheimers disease. While that
research is underway, it certainly
makes sense to control blood sugar.
But the way to do this is not to
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References
1. Vinson J. The potential health benefts of
antioxidants. American Chemical Society
symposium. Aug 28, 2005. Washington, DC.
2. Am J Clin Nutr. 2006 May;83(5)1039-46.
3. Int J Cardiol. 2009; 137:216-25.
4. Am Heart J. 2009 Mar;157(3):495-501.
5. Arch Intern Med. 2009;169:2053-63.
6. J Intern Med. 2004;255(1):89-95.
7. JAMA. 2004;291:1213-9.
8. J Natl Cancer Inst. 2011 Jun 8;103(11):876-84.
9. Breast Cancer Res. 2011 May 14;13(3):R49.
10. JNCI Journal of the National Cancer Institute.
2005 Feb;97(4):293-300.
11. Eur J Neurol. 2002 Jul;9(4):377-82.
12. J Alzheimers Dis. 2011;25(2):323-35.
13. J Alzheimers Dis. 2010;20 Suppl 1:S117-26.
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* US Patent 6,723,368.
Chlorogenic Acid Chlorogenic Acid
Conventional Cofee 92 mg Rich Rewards Cofee Blend 172 mg
(Cafeinated) (Cafeinated)

Conventional Cofee 46 mg Rich Rewards Cofee Blend 132 mg
(Decafeinated) (Decafeinated)

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References
1. Anal Chim Acta. 2007 Feb 5;583(2):402-10.
2. J Agric Food Chem. 2007 Sep 5;55(18):7609-14.
3. Lipids. 2001 Nov;36(11):1195-202.
4. Eur J Cancer. 2000 Jun;36(10):1235-47.
5. Phytother Res. 2008;22:1239-42.
6. Benolea
EFLA 943. Unpublished study. October 11, 2011.

7. J Ethnopharmacol. 2008 Nov 22;120(2):233-40.
8. Int J Food Sci Nutr. 2005 Dec;56(8):613-20.
9. Handbuch Phytotherapie. Stuttgart,
Germany: Wissenschaftliche Verlagsgesellschaft; 2003.
10. J Pharm Belg. 1996 Mar-Apr;51(2):69-71.
11. Therapie. 1999 Nov-Dec;54(6):717-23.
12. Ann Pharm Fr. 2000 Jul;58(4):271-7.
13. Arznei-forschung. 1972 Sep;22(9):1476-86.
14. Phytomedicine. 2011 Feb 15;18(4):251-8.
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Many of the validated benefts of the Mediterranean
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lood testing provides the ultimate
information regarding correctable risk
factors that may predispose you to disorders
such as cancer, diabetes, cardiovascular
disease, and more. Information about
general health and nutritional status can
also be gained through standard blood
analysis. Standing behind the belief that
blood testing is an essential component
of any program designed to attain optimal
health and longevity, Life Extension
offers
this innovative and convenient service
at a very affordable price. Not only is
comprehensive blood testing an important
step in safeguarding your health, it is a
simple process from virtually anywhere in
the United States.
Five Easy Steps:
1. Call 1-800-208-3444 to discuss
and place your order with one of our
knowledgeable health advisors.
(This order form can also be faxed
to 1-866-728-1050 or mailed).
Online orders can also be placed at
www.lifeextension.com.
2. After your order is placed, you will be
mailed either a requisition form to take
to your local LabCorp Patient Service
Center or a Blood Draw Kit; whichever is
applicable (Please note: If a blood draw
kit is used, an additional local draw fee
may be incurred.)
3. Have your blood drawn.
4. Your blood test results will be sent directly
to you by Life Extension.
5. Take the opportunity to discuss the results
with one of our knowledgeable health
advisors by calling 1-800-226-2370;
or review the results with your personal
physician.
Its that simple! Dont delaycall today!
For Our Local Members:
For those residing in the Ft. Lauderdale,
Florida area, blood-draws are also
performed at the Life Extension Nutrition
Center from 9:00 am to 2:00 pm Monday
through Saturday. Simply purchase the blood
test and have it drawn with no wait!
Our address is 5990 North Federal Highway,
Ft. Lauderdale, FL, 33308-2633.
MOST POPULAR PANELS
Life Extension Member Pricing
THE CBC/CHEMISTRY PROFILE (LC381822) $35
OVER 40 PARAMETERS TESTED
CARDIOVASCULAR RISK PROFILE
Total Cholesterol Cholesterol/HDL Ratio
HDL Cholesterol Estimated CHD Risk
LDL Cholesterol Glucose
Triglycerides Iron
LIVER FUNCTION PANEL
AST (SGOT) Total Bilirubin
ALT (SGPT) Alkaline Phosphatase
LDH
KIDNEY FUNCTION PANEL
BUN BUN/Creatinine Ratio
Creatinine Uric Acid
BLOOD PROTEIN LEVELS
Total Protein Globulin
Albumin Albumin/Globulin Ratio
BLOOD COUNT/RED AND WHITE BLOOD
CELL PROFILE
Red Blood Cell Count Monocytes
White Blood Cell Count Lymphocytes
Eosinophils Platelet Count
Basophils Hemoglobin
Polys (Absolute) Hematocrit
Lymphs (Absolute) MCV
Monocytes (Absolute) MCH
Eos (Absolute) MCHC
Baso (Absolute) Polynucleated Cells
RDW
BLOOD MINERAL PANEL
Calcium Sodium
Potassium Chloride
Phosphorus Iron
NOTE: CBC/Chemistry prole is included in the Male
and Female Life Extension panels and Weight Loss Panels.
GENERAL HEALTH
HEMOGLOBIN A1C (HBA1C) (LC001453) $31
Hemoglobin A1C evaluates long-term blood
sugar control. Serum glucose sometimes reacts
with important proteins in the body rendering
them nonfunctional. Since this process, known
as glycation is one of the leading theories of
aging, Life Extension
believes everyone
should check their A1C level.
VITAMIN D (250H) (LC081950) $47
This test is used to rule out vitamin D
deciency as a cause of bone disease.
It can also be used to identify hypercalcemia.
FOOD SAFE ALLERGY TEST** (LCM73001) $198
This test measures delayed (IgG) food
allergies for 95 common foods.
ASPIRINWORKS* (LC501620) $149
Taking aspirin to prevent heart attack?
Is it working? This is a random urine test
used to measure your resistance to aspirin.
OMEGA SCORE
** (LCOMEGA) $131.25
Provides valuable information on your risk
of developing heart disease, sudden heart
attack, and cardiac death. The Omega
Score also includes your AA:EPA ratio,
allowing you to determine and track a major
factor in total body inammation.
COQ10* (COENZYME Q10) (LC120251) $145
This test is used to check the blood level
of CoQ10 and will enable more precise
dosing for anyone seeking to achieve and
maintain high levels of this critical antioxidant.
The Ultimate Information
* This test requires samples to be shipped to the lab on dry ice for customers using a Blood Draw Kit and will incur an
additional $35 charge. If the customer is having blood drawn at a LabCorp facility, this extra charge does not apply.
** This test is packaged as a kit, requiring a nger stick performed at home.
COMPREHENSIVE PANELS
MALE LIFE EXTENSION PANEL (LC322582) $269
Chemistry Prole includes glucose, cholesterol,
LDL, HDL, triglycerides, liver and-kidney function
tests PLUS 20 additional tests. CBC includes immune
(white) cell count, red blood cell count and platelet
count. Also includes: C-Reactive Protein
DHEA-S Homocysteine
TSH for thyroid function Free Testosterone
Estradiol Total Testosterone
Vitamin D 25- hydroxy PSA (prostate-specic antigen)
LIMITED TIME OFFER (February 1-March 25, 2013)
now includes: Fibrinogen and HbA1C
FEMALE LIFE EXTENSION PANEL (LC322535) $269
DHEA-S Homocysteine
TSH for thyroid function Free Testosterone
Progesterone Vitamin D 25- hydroxy
LIMITED TIME OFFER (February 1-March 25, 2013)
now includes: Fibrinogen and HbA1C
MALE WEIGHT LOSS PANEL (LCWLM) $299
DHEA-S Insulin
SHBG Free Testosterone
Free T3 Free T4
TSH for thyroid function PSA (prostate-specic antigen)
FEMALE WEIGHT LOSS PANEL (LCWLF) $299
DHEA-S Insulin
Progesterone Free Testosterone
Free T3 Free T4
TSH for thyroid function SHBG
MALE HORMONE ADD-ON PANEL (LCADDM)* $155
Pregnenolone and Dihydrotestosterone (DHT)
To provide an even more in-depth analysis of a mans
hormone status, Life Extension has created this panel
as an addition to the Male Life Extension Panel.
This panel provides valuable information about a
testosterone metabolite that can affect the prostate,
and the mother hormone that acts as a precursor
to all other hormones.
FEMALE HORMONE ADD-ON PANEL (LCADDF)* $125
Pregnenolone and Total Estrogens
To provide an even more in-depth analysis of a womans
hormone status, Life Extension has created this panel
as an addition to the Female Life Extension Panel.
This panel provides valuable information about total
estrogen status, and the mother hormone that
acts as a precursor to all other hormones.
LIFE EXTENSION THYROID PANEL (LC304131) $75
TSH, T4, Free T3, Free T4.
FEMALE COMPREHENSIVE HORMONE PANEL* $299
(LC100011) CBC/Chemistry Prole
(see description above), DHEA-S, Estradiol,
Total Estrogens, Progesterone, Pregnenolone,
Total and Free Testosterone, SHBG, TSH, Free T3.
MALE COMPREHENSIVE HORMONE PANEL* $299
(LC100010) CBC/Chemistry Prole
(see description above), DHEA-S, Estradiol,
DHT, PSA, Pregnenolone, Total and
Free Testosterone, SHBG, TSH, Free T3.
TERMS AND CONDITIONS
This blood test service is for informational
purposes only and no specic medical
advice will be provided. National Diagnostics,
Inc., and the Life Extension Foundation
contract with a physician who will order
your test(s), but will not diagnose or treat
you. Both the physician and the testing
laboratory are independent contractors and
neither National Diagnostics, Inc., nor the
Life Extension Foundation
will be liable
for their acts or omissions. Always seek the
advice of a trained health professional for
medical advice, diagnosis, or treatment.
When you purchase a blood test from Life
Extension/National Diagnostics, Inc., you
are doing so with the understanding that
you are privately paying for these tests.
There will be absolutely no billing to
Medicare, Medicaid, or private insurance.
I have read the above Terms and Conditions
and understand and agree to them.

Signature of Life Extension Member
X
Life Extension Foundation Members only
MEMBER NO.
Male Female
Mail your order form to:
3600 West Commercial Boulevard
Fort Lauderdale, FL 33309
Phone your order to: 1-800-208-3444
Fax your order to: 1-866-728-1050
NATIONAL DIAGNOSTICS, INC.
ORDER LIFE-SAVING
BLOOD TESTS
FROM VIRTUALLY
ANYWHERE IN THE US!
Name
Date of Birth
/ /
Address
City
State Zip
Phone
Credit Card No.
Expiration Date /
(required)
ENERGY PROFILE (LC100005) $375
CBC/Chemistry Prole (see description),
Epstein Barr Virus antibodies (IgG and IgM),
Cytomegalovirus Antibodies (IgG and IgM), Ferritin,
Total and Free Testosterone, DHEA-S, Free T3, Free T4,
Cortisol, C-Reactive Protein (high sensitivity),
Vitamin B12, Folate, Insulin.
ANEMIA PANEL (LC100006) $86
CBC/Chemistry Prole (see description),
Ferritin, Total Iron Binding Capacity (TIBC),
Vitamin B12, Folate, Reticulocyte Count.
INFLAMMATION PANEL (LC100007) $135
CBC/Chemistry Prole (see description above),
C-Reactive Protein (high sensitivity),
Sedimentation Rate, Rheumatoid (RA) Factor,
Antinuclear Antibodies (ANA) Screen.
THYROID ANTIBODY PROFILE (LC100004) $99
Thyroid Antithyroglobulin Antibody (ATA) and
Thyroid Peroxidase Antibody (TPO).
Popular Single Tests
HORMONES
CORTISOL (LC004051) $39
This test is to measure adrenal function.

DHEA-SULFATE (LC004020) $61
This test shows if you are taking the proper
amount of DHEA. This test normally costs $100
or more at commercial laboratories.
DIHYDROTESTOSTERONE (DHT)* (LC500142) $99
Measures serum concentrations of DHT.
ESTRADIOL (LC004515) $33
For men and women. Determines the proper
amount in the body.
INSULIN FASTING (LC004333) $42
Can predict those at risk of diabetes,
obesity, and heart and other diseases.
PREGNENOLONE* (LC140707) $116
Used to determine ovarian failure, hirsutism,
adrenal carcinoma, and Cushings syndrome.
PROGESTERONE (LC004317) $55
Primarily for women. Determines the proper
amount in the body.
SEX HORMONE BINDING GLOBULIN (SHBG) $33
(LC082016)
This test is used to monitor SHBG levels which
are under the positive control of estrogens and
thyroid hormones, and suppressed by androgens.
SOMATOMEDIN C (IGF-1) (LC010363) $75
Indicates growth hormone secretion levels. Low
levels have been associated with atherosclerosis
as well as all-cause mortality.
Other Popular Panels
Life Extension Member Pricing
For non-member prices
call 1-800-208-3444
This is NOT a complete listing of
LE blood test services. Call 1-800-208-3444
for additional information.
CARDIAC RISK
Lp-PLA2 (PLAC TEST)* (LC123240) $125
This test is used to aid in predicting risk for
coronary heart disease, and ischemic stroke
associated with atherosclerosis. Lp-PLA2 is a
cardiovascular risk factor that provides unique
information about the stability of the plaque
inside your arteries.
C-REACTIVE PROTEIN (HIGH-SENSITIVITY) $42
(LC120766)
Measures inammation factors in arteries.
Recent studies indicate that C-reactive protein
may be the most accurate risk factor for predicting
heart attack and stroke.
CARDIAC PLUS
(LC100008) $145
CBC/Chemistry prole (see description),
Vitamin D 25-hydroxy, C-Reactive Protein
(high sensitivity), Fibrinogen, Homocysteine.
VAP PLUS* (LC100009) $330
VAP, C-Reactive Protein (high sensitivity),
Homocysteine, Fibrinogen, PLAC
Test (Lp-PLA2),
Vitamin D 25-hydroxy.
FIBRINOGEN* (LC001610) $31
High levels of this blood-clotting factor
increase the risk of heart attack and stroke.
HOMOCYSTEINE (LC706994) $64
Can indicate if you are likely to have a heart attack
or stroke. Even if you take folic acid, you still may
have dangerously high levels of this artery-clotting
metabolic debris that can be lowered with high
doses of TMG, vitamin B6, and vitamin B12.
VAP TEST* (LC804500) $90
The VAP cholesterol test provides a more
comprehensive coronary heart disease (CHD) risk
assessment than the conventional lipid prole.
Direct measurements, not estimations, are
provided for total cholesterol, LDL, HDL, VLDL,
and cholesterol subclasses.
MALE HEALTH
PSA (PROSTATE-SPECIFIC ANTIGEN) $31
(LC010322)
Can provide an early warning sign for prostate
disorders and possible cancer.
FREE-PSA (INCLUDES TOTAL PSA)* (LC480780) $61
Recommended to determine if an elevated PSA
is indicative of prostate cancer.
BONE HEALTH
OSTEOCALCIN* (LC010249) $91
Osteocalcin is often used as a biochemical
marker, or biomarker, for the bone formation
process. It has been routinely observed that
higher serum osteocalcin levels are relatively
well correlated with bone diseases characterized
by increased bone turnover, especially osteoporosis.
DPD CROSS LINK URINE TEST (LC511105) $79
The deoxypyridinoline (DPD) urine test can be
used to measure bone re-absorption rates in
healthy individuals and in those with enhanced
risk of developing metabolic bone diseases.
Deoxypyridinoline can be used to monitor
therapies (which may include bisphosphonate
drugs) in people diagnosed with osteoporosis.
Blood tests available only in
the continental United States.
Not avaiable in Maryland.
AMINO ACIDS
Acetyl-L-Carnitine
Acetyl-L-Carnitine-Arginate
Branched Chain Amino Acids
D, L-Phenylalanine Capsules
Glycine Capsules
L-Arginine Capsules
Arginine/L-Ornithine Capsules
L-Carnitine Capsules
L-Carnitine Powder Natural Lemon Flavor
L-Glutathione, L-Cysteine & C
L-Glutamine Capsules
L-Glutamine Powder
L-Lysine Capsules
L-Tyrosine Tablets
Mega L-Glutathione Capsules
N-Acetyl-L-Cysteine Capsules
Optimized Carnitine with GlycoCarn
PharmaGABA
Super Carnosine Capsules
Taurine Capsules
BONE & JOINT HEALTH
ArthroMax with Theaavins and AprsFlex
ArthroMax Advanced with UC-II
and
AprsFlex
Bone-Up
Bone Restore
Bone Restore w/Vitamin K2
Bone Strength Formula w/KoAct
Chondrox
Fast Acting Joint Formula
Glucosamine Chondroitin Capsules
BRAIN HEALTH
Acetyl-L-Carnitine
CDP Choline Capsules
Cognitex
with NeuroProtection Complex

Cognitex
with Pregnenolone &

NeuroProtection Complex
Cognitex
Basics
DMAE
Ginkgo Biloba Certied Extract
Huperzine A
Lecithin with B5 and BHA
Lecithin Granules
Methylcobalamin Lozenges
Neuro-Mag Magnesium L-Threonate
Optimized Ashwagandha Extract
Phosphatidylserine Capsules
Rhodiola Extract
Super Ginkgo Extract
Vinpocetine
DIGESTIVE
Bido GI Balance
Carnosoothe w/PicroProtect
Digest RC
Enhanced Super Digestive Enzymes
Extraordinary Enzymes
Life Flora
Natural EsophaGuard
Pancreatin
Probiotic All-Flora
Probiotic Anti-Aging
Regimint
Theralac Probiotics
DURK AND SANDY PRODUCTS
Blast
Dual-C
Inner Power
Memory Upgrade
EYE CARE
Bilberry Extract
Brite Eyes III
Eye Pressure Support with Mirtogenol
Overxcast Polarized Sunglasses

Solarshield Sunglasses
Super Zeaxanthin with Lutein &
Meso-Zeaxanthin Plus Astaxanthin and C3G
Super Zeaxanthin with Lutein &
Meso-Zeaxanthin and C3G
FIBER
AppleWise Polyphenol
Fiber Food
Hi-Lignan
Nutri-Flax
TruFiber
WellBetX PGX
Soluble Fiber Blend

FOOD
Rich Rewards Black Bean Vegetable Soup
Rich Rewards Spicy Cruciferous Vegetable Soup
Rich Rewards Cruciferous Vegetable Soup
Rich Rewards Lentil Soup
Rich Rewards Coffee
HAIR CARE
Dr. Proctors Advanced Hair Formula
Dr. Proctors Shampoo
Super-Absorbable Tocotrienols
HEART HEALTH
AppleWise Polyphenol
Advanced Lipid Control
Aspirin (Enteric Coated)
Cardio Peak w/Standarized Hawthorn and Arjuna
Cho-Less
D-Ribose Capsules
D-Ribose Powder
Endothelial Defense with
Fibrinogen Resist
Forskolin
Homocysteine Resist
Krill Healthy Joint Formula
Natural BP Management
Olive Leaf Vascular Support
Peak ATP
with GlycoCarn
PhosphOmega
Policosanol
Pycnogenol
French Maritime Pine Bark Extract

Red Yeast Rice
Super Absorbable CoQ10 with d-Limonene
Super Omega-3 EPA/DHA with Sesame
Lignans & Olive Fruit Extract
Super Ubiquinol CoQ10
Super Ubiquinol CoQ10 with Enhanced
Mitochondrial Support
Sytrinol
Theaavin Standardized Extract
TMG Powder
TMG Tablets
HERBAL/PHYTO PRODUCTS
Artichoke Leaf Extract
Astaxanthin
Berry Complete
Bio-Enhanced Astaxanthin w/Phospholipids
Blueberry Extract
Blueberry Extract w/Pomegranate
Butterbur Extract w/Standardized
Rosmarinic Acid
Calcium D-Glucarate
Cilantro Herbal Extract
Enhanced Berry Complete with RZD Acai
Grapeseed Extract with Resveratrol &
Pterostilbene
Huperzine A
Kyolic
Garlic Formula 105

Kyolic
Reserve
Mega Green Tea Extract
Mega Green Tea Extract (Decaffeinated)
(also w/ CoffeeGenic Green Coffee Extract)
Mega Lycopene Extract
Nutrim
Optimized Ashwagandha Extract
Optimized Garlic
Pomegranate Extract
Pomegranate Juice Concentrate
ProGreens
Pure-Gar
Pycnogenol
Optimized Quercetin
Resveratrol with Synergistic Grape-Berry Actives
Rhodiola Extract
Rosmarinic Acid Extract
Silymarin
SODzyme with GliSODin
Stevia Extract
Super Bio-Curcumin
Super Ginkgo Extract

Triple Action Cruciferous Vegetable Extract
Venotone
Whole Grape Extract
HORMONES
Advanced Natural Sex for Women

50+
Cordyceps CS-4
7-Keto
DHEA
DHEA
DHEA Complete
GH Pituitary Support Day Formula
GH Pituitary Support Night Formula
Melatonin
Melatonin Timed Release
Natural Estrogen with Pomegranate Extract
Pregnenolone
ProgestaCare for Women
Pure IGF
Super Miraforte with Standarized Lignans
IMMUNE ENHANCEMENT
AHCC
(Active Hexose Correlated Compound)

Black Cumin Seed Oil
Black Cumin Seed Oil w/Bio-Curcumin
Buffered Vitamin C Powder

Echinacea Extract
Enhanced Life Extension Whey Protein
i26 Hyperimmune Egg
Immune Protect with PARACTIN
Lactoferrin
Norwegian Shark Liver Oil
Optimized Fucoidan w/Maritech

926
Primal Defense
ProBoost Thymic Protein A
Pure Gar
Reishi Extract Mushroom Complex
Vitamin C with Dihydroquercetin
Zinc Lozenges with Vitamin C
INFLAMMATORY REACTIONS
Arthro-Immune Joint Support
ArthroMax with Theaavins
Boswella
Boswella Topical Cream
Bromelain (Specially-coated)
DHA (Vegetarian Sourced)
Fast Acting Joint Formula
Ginger Force
Krill Oil
5-LOX

Inhibitor w/AprsFlex
Mega EPA/DHA
Mega GLA with Sesame Lignans
MSM
Natural Relief 1222 Cream
Omega-3 Whirl
Serraazyme
SODzyme with GliSODin
and Wolfberry
Super Omega-3 EPA/DHA with Sesame
Lignans & Olive Fruit Extract
Tart Cherry
Zyamend
Whole Body
LIVER HEALTH
Branch Chain Amino Acids
N-Acetyl Cysteine
Liver Efciency Formula
Certied European Milk Thistle
Hepatopro
SAMe
Silymarin
PRODUCTS
MINERALS
Biosil
Bone Restore
Bone Strength Formula w/KoAct
Bone-Up
Boron Capsules
Calcium Citrate with D3
Chromium Ultra
Copper
Iodoral
Iron Protein Plus
Magnesium
Magnesium Citrate
Only Trace Minerals
Optimized Chromium w/Crominex
3+
OptiZinc
Sea-Iodine
Selenium
Se-Methyl L-Selenocysteine
Strontium
Vanadyl Sulfate
Zinc/Vitamin C Lozenges
MISCELLANEOUS
Blender
Blood Pressure Monitor Arm Cuff Medium
Cell Sensor Gauss Meter
CR Way Edition Advanced Dietary Software
The Capsule Filler Machine
MITOCHONDRIAL SUPPORT
Acetyl-L-Carnitine
Mitochondrial Basics w/BioPQQ
Mitochondrial Energy Optimizer w/BioPQQ
Optimized Carnitine with GlycoCarn
Super Absorbable CoQ10 with d-Limonene

Super Alpha Lipoic Acid with Biotin
Super R-Lipoic Acid
Super Ubiquinol CoQ10 with Enhanced
Mitochondrial Support
MOOD RELIEF
Adrenal Energy Formula
Bioactive Milk Peptides
L-Theanine
5 HTP
Enhanced Natural Sleep
w/ Melatonin
Enhanced Natural Sleep
w/o Melatonin
Natural Stress Relief
Stabilium
200
SAMe
St. Johns Wort Extract
MOUTH CARE
Advanced Oral Hygiene
Mist Oral III with CoQ10
Mouthwash w/Pomegranate
Toothpaste
MULTIVITAMIN
Childrens Formula Life Extension Mix
Comprehensive Nutrient Packs Basic
Comprehensive Nutrient Packs Advanced
Life Extension Booster
Life Extension Mix Capsules
Life Extension Mix Powder
Life Extension Mix Tablets
Life Extension Mix w/o Copper Capsules
Life Extension Mix w/o Copper Tablets
Life Extension Mix w/Extra Niacin
Life Extension Mix w/Extra Niacin w/o Copper
Life Extension Mix w/Stevia Powder
Life Extension Mix w/Stevia w/o Copper Powder
Life Extension One-Per-Day
Life Extension Two-Per-Day
Super Booster Softgels w/Advanced K2 Complex
PET CARE
Cat Mix
Dog Mix
PROSTATE & URINARY HEALTH
BetterWOMAN
Optimized Cran-Max
with UTIRose
5-LOXIN
(Water-Soluble) Pumpkin Seed Extract

Super Saw Palmetto with Beta-Sitosterol
Super Saw Palmetto/Nettle Root Formula
w/Beta-Sitosterol
Ultra Natural Prostate Formula
SKIN CARE
Advanced Under Eye Serum with Stem Cells
Amber Self MicroDermAbrasion
Anti-Aging Mask
Anti-Glycation Serum
Antioxidant Rejuvenating Foot Cream
Antioxidant Rejuvenating Foot Scrub
Antioxidant Rejuvenating Hand Cream
Antioxidant Rejuvenating Hand Scrub
Anti-Redness & Blemish Lotion
Bio-Collagen w/Patented UC-II
Bioavonoid Cream
Broccoli Sprout
Corrective Clearing Mask
DermaWhey
DNA Repair Cream
Dual-Action MicroDermAbrasion
Essential Plant Lipids Reparative Serum
Face Master

Platinum
Face Rejuvenating Antioxidant Cream
Enhanced FernBlock

with Sendara
Fine Line-Less
Hair Suppress Formula
Healing Formula All-in-One Cream
Healing Mask
Hyaluronic Facial Moisturizer
Hydrating Anti-oxidant Face Mist
Hydroderm
Lavilin Underarm Deodorant

Lifting & Tightening Complex
Lycopene Cream
Melatonin Cream
Mild Facial Cleanser
Neck Rejuvenating Antioxidant Cream
Peel Off Cleansing Mask
Pigment Correcting Cream
(Ultra) Rejuvenex
Rejuvenex
Body Lotion
RejuveneX
Factor
RejuveneX
Factor Firming Serum

Rejuvenating Serum
Resveratrol Anti-Oxidant Serum
Skin Lightening Serum
Skin Restoring Phytoceramides w/Lipowheat
Skin Stem Cell Serum
Stem Cell Cream w/Alpine Rose
Supercritical Omega 7
Total Sun Protection Cream
Ultra Rejuvenex
Ultra RejuveNight
w/o Progesterone
Ultra Lip Plumper
Ultra Wrinkle Relaxer
Under Eye Rening Serum
Under Eye Rescue Cream
Vitamin C Serum
Vitamin D Lotion
Vitamin E-ssential Cream
Vitamin K Healing Cream
SOY
Natural Estrogen w/Pomegranate
Super Absorbable Soy Isoavones
SPECIAL PURPOSE FORMULA
Anti-Alcohol Antioxidants w/HepatoProtection
Complex
Benfotiamine w/Thiamine
Breast Health Formula
Butterbur Extract w/Standardized
Rosmarinic Acid
Chlorella
Chlorophyllin w/Zinc
Green Coffee Extract CoffeeGenic
(also w/Glucose control)
Coriolus Super Strength
CR Mimetic Longevity Formula
Cinsulin
w/InSea
2

and Crominex

3+
European Leg Solution Diosmin 95
Fem Dophilus
Femmenessence MacaPause
Hearos Ear Plugs

Migra-eeze
Natural Female Support
Organic Total Body Cleanse
Pecta-Sol
Potassium Iodide
PQQ Caps with BioPQQ
PteroPure
Prelox

Natural Sex for Men
Pyridoxal 5 - Phosphate
Rosmarinic Acid Extract
Ultra Natural Prostate w/AprsFlex
and Standardized Lignans
SPORTS PERFORMANCE
Creatine Capsules
Enhanced Life Extension Protein
DMG (N, N-dimethylglycine)
L-Glutamine Capsules
L-Glutamine Powder
VITAMINS
Ascorbyl Palmitate Capsules
B2
B12
Beta-Carotene
Biotin Capsules
Buffered Vitamin C Powder
Complete B Complex
Folic Acid + B12
Gamma E Tocopherol w/Sesame Lignans
Gamma E Tocopherol/Tocotrienols
Inositol Capsules
Mega Lycopene Extract
Methylcobalamin
MK-7
No-Flush Niacin
Optimized Folate
Super Ascorbate C Capsules
Super Ascorbate C Powder
Super K w/Advanced K2 Complex
Tocotrienols w/Sesame Lignans
Vitamin A Nutrisorb
Vitamin B3 (Niacin) Capsules
Vitamin B6
Vitamin B12 Tablets
Vitamin C
Vitamin D
Vitamin D3
Vitamin D3 w/Sea-Iodine
Vitamins D and K w/Sea-Iodine
Vitamin E
Vitamin K1
WEIGHT MANAGEMENT
Alli

Rell Pack
Advanced Anti-Adipocyte Formula
w/AdipoStat & Integra Lean
Calorie Control Weight Management Formula

w/CoffeeGenic Green Coffee Extract
CoffeeGenic Weight Management with
Green Coffee Extract
7-Keto DHEA
DHEA
Complete
Fucoxanthin Slim
HCA
Integra-Lean
Irvingia
LuraLean
Caps Special Propolmannan

Particle Size
Optimized Irvingia w/Phase 3 Calorie
Control Complex
Optimized Saffron with Satiereal
Natural Appetite Control

Natural Glucose Absorption Control
Stevia Liquid Extract
Super CLA Blend w/Guarana and
Sesame Lignans
Super CLA Blend w/Sesame Lignans
WellBetX PGX
Soluble Fiber Blend

PRODUCTS
Buyers Club Order Form
APRIL 2013 LIFE EXTENSION MEMBERS RECEIVE 25% OFF THE RETAIL PRICE OF ALL PRODUCTS
SUB-TOTAL OF COLUMN 1 SUB-TOTAL OF COLUMN 1
To order call: 1.954.766.8433 or 1.800.544.4440
No. Retail Member Qty Total
Each Each
Each Each
01206 BERRY COMPLETE - 30 veg. caps $21.00 $15.75
Buy 4 bottles, price each 18.67 14.00
01406 BERRY COMPLETE w/RZD
TM
ACAI (ENHANCED) - 60 veg. caps 29.00 21.75
00664 BETA-CAROTENE - 25,000 IU, 100 softgels 11.25 8.44
00653 BETTERWOMAN
- 40 caps 40.00 30.00

01622 BIFIDO GI BALANCE - 60 veg. caps 20.00 15.00
01073 BILBERRY EXTRACT - 100 mg, 100 veg. caps 42.00 31.50
01512 BIOACTIVE MILK PEPTIDES - 30 caps 18.00 13.50
01631 BIO-COLLAGEN w/PATENTED UC-II
- 60 caps 36.00 27.00

*01006 BIOSIL
TM
- 5 mg, 30 veg. caps 18.95 15.16
*01007 BIOSIL
TM
- 1 oz 29.99 23.99
00102 BIOTIN - 600 mcg, 100 caps 7.50 5.63
01709 BLACK CUMIN SEED OIL - 60 softgels 16.00 12.00
01710 BLACK CUMIN SEED OIL w/BIO-CURCUMIN
- 60 softgels 32.00 24.00

01008 BLAST
TM
- 600 grams of powder 26.95 20.21
51526 BLENDER - 28 oz bottle 8.99 6.74
70000 BLOOD PRESSURE MONITOR - ARM CUFF (medium) 99.95 64.97
70004 BLOOD PRESSURE MONITOR - WRIST (travel size) 69.95 52.46
01214 BLUEBERRY EXTRACT - 60 veg. caps 22.50 16.88
01438 BLUEBERRY EXTRACT w/ POMEGRANATE - 60 veg. caps 30.00 22.50
01611 BONE RESTORE - 150 caps 22.50 16.88
01711 BONE RESTORE W/VITAMIN K2 - 150 caps 26.00 19.50
01211 BONE STRENGTH FORMULA w/KOACT
- 120 caps 42.00 31.50

00313 BONE-UP
- 240 caps 24.95 18.71

01379 BOOSTER - 60 softgels 48.00 36.00
01680 BOOSTER w/ADVANCED K2 COMPLEX (SUPER) - 60 softgels 42.00 31.50
01661 BORON - 3 mg, 100 veg. caps 5.95 4.46
00202 BOSWELLA - 100 caps 38.00 28.50
00258 BOSWELLA TOPICAL CREAM - 4 oz 15.00 11.25
Buy 4 jars, price each 13.00 9.75
01253 BRANCHED CHAIN AMINO ACIDS - 90 veg. caps 19.50 14.63
A
01524 ACETYL-L-CARNITINE - 500 mg, 100 veg. caps $34.00 $25.50
01525 ACETYL-L-CARNITINE ARGINATE - 100 veg. caps 59.00 44.25
01628 ADRENAL ENERGY FORMULA - 60 veg. caps 24.00 18.00
01630 ADRENAL ENERGY FORMULA - 120 veg. caps 46.00 34.50
01308 ADVANCED LIPID CONTROL - 60 veg. caps 30.00 22.50
01521 ADVANCED ORAL HYGIENE - 60 veg. mint lozenges 20.00 15.00
00681 AHCC - 500 mg, 30 caps 59.98 44.99
*46925 ALLI
REFILL PACK - 120 caps 69.95 58.00

00457 ALPHA-LIPOIC ACID W/BIOTIN (SUPER) - 250 mg, 60 caps 37.00 27.75
01440 ANTI-ALCOHOL ANTIOXIDANTS w/HEPATOPRO - 100 caps 26.00 19.50
01509 ANTI-ADIPOCYTE FORMULA w/ADIPOSTAT 39.00 29.25
& INTEGRA LEAN
(ADVANCED) - 60 veg. caps

01625 APPLEWISE POLYPHENOL EXTRACT - 600 mg, 30 veg. caps 21.00 15.75
01039 ARGININE/ORNITHINE - 500/250, 100 caps 16.00 12.00
00038 ARGININE/ORNITHINE POWDER - 150 grams 22.95 17.21
01624 (L)-ARGININE CAPS - 700 mg, 200 veg. caps 26.50 19.88
01617 ARTHROMAX
TM
w/THEAFLAVINS & APRESFLEX
TM
- 120 veg. caps 44.00 33.00
01618 ARTHROMAX
TM
ADVANCED w/UC-II
& APRESFLEX
TM
- 60 caps 36.00 27.00
01404 ARTHRO-IMMUNE JOINT SUPPORT - 60 veg. caps 32.00 24.00
00919 ARTICHOKE LEAF EXTRACT - 500 mg, 180 veg. caps 28.00 21.00
01533 ASCORBYL PALMITATE - 500 mg, 100 veg. caps 22.50 16.88
00888 ASHWAGANDHA EXTRACT (OPTIMIZED) - 60 veg. caps 10.00 7.50
01066 ASPIRIN - 81 mg, 300 enteric coated tablets 6.00 4.50
00708 ASTAXANTHIN - 2 mg, 30 softgels 10.25 7.69
01720 ASTAXANTHIN WITH PHOSPHOLIPIDS (BIO-ENHANCED) - 4 mg, 30 softgels 16.00 12.00
B
00920 BENFOTIAMINE W/ THIAMINE - 100 mg, 120 veg. caps $19.95 $14.96
00925 BENFOTIAMINE (MEGA) - 250 mg, 120 veg. caps 30.00 22.50
`
`
LIFE EXTENSION MEMBERS RECEIVE 25% OFF THE RETAIL PRICE OF ALL PRODUCTS APRIL 2013
To order online visit: www.LifeExtension.com
Each Each
Each Each
SUB-TOTAL OF COLUMN 4
01477 CHROMIUM ULTRA - 100 veg. caps $24.00 $18.00
01504 CHROMIUM W/CROMINEX
3+ (OPTIMIZED) - 500 mcg, 60 veg. caps 9.00 6.75

00551 CILANTRO HERBAL EXTRACT - 1 oz 12.00 9.00
01503 CINSULIN
W/INSEA
2
AND CROMINEX
3+- 90 veg. caps 38.00 28.50

00818 CLA BLEND W/SESAME LIGNANS (SUPER) - 1000 mg, 120 softgels 36.00 27.00
00819 CLA BLEND w/GUARANA & SESAME (SUPER)-1000 mg, 120 softgels 42.00 31.50
01707 COFFEEGENIC
TM
WEIGHT MANAGEMENT
TM
48.00 36.00
w/GREEN COFFEE EXTRACT - 90 veg. caps
01697 COGNITEX
w/PREGNENOLONE & 74.00 55.50

NEUROPROTECTION COMPLEX - 90 softgels
01696 COGNITEX
w/o PREGNENOLONE 72.00 54.00

w/NEUROPROTECTION COMPLEX - 90 softgels
01421 COGNITEX
BASICS - 60 softgels 38.00 28.50

00110 COMPLETE B-COMPLEX - 180 caps 21.50 16.13
01795 COMPREHENSIVE NUTRIENT PACKS BASIC - 30 packs 48.00 36.00
Buy 4 boxes, price each 44.00 33.00
01796 COMPREHENSIVE NUTRIENT PACKS ADVANCED - 30 packs 90.00 67.50
00119 COPPER CAPSULES - 2 mg, 100 caps 9.91 7.43
00949 COQ10
TM
w/ d-LIMONENE (SUPER ABSORBABLE) - 50 mg, 60 softgels 25.00 18.75
00950 COQ10
TM
w/ d-LIMONENE (SUPER ABSORBABLE) - 100 mg, 100 softgels 66.00 49.50
01226 COQ10 (SUPER UBIQUINOL) - 100 mg, 60 softgels 56.00 42.00
01426 COQ10 W/ENH MITOCHONDRIAL SUPPORT (SUPER UBIQUINOL)-100 mg, 60 softgels 62.00 46.50
01425 COQ10 w/ENH MITOCHONDRIAL SUPPORT (SUPER UBIQUINOL)-50 mg, 100 softgels 58.00 43.50
01427 COQ10 w/ENH MITOCHONDRIAL SUPPORT(SUPER UBIQUINOL)-50 mg, 30 softgels 20.00 15.00
01699 BREAST HEALTH FORMULA - 60 veg. caps $34.00 $25.50
00893 BRITE EYES III - 2 vials, 5 ml each 34.00 25.50
01203 BROMELAIN (SPECIALLY-COATED) - 500 mg, 60 enteric coated tablets 21.00 15.75
00884 BUTTERBUR EXT. w/STANDARDIZED ROSMARINIC ACID - 60 softgels 44.00 33.00
C
01653 CALCIUM CITRATE w/VITAMIN D - 300 veg. caps $24.00 $18.00
01651 CALCIUM D-GLUCARATE - 200 mg, 60 veg. caps 18.00 13.50
01693 CALORIE CONTROL WEIGHT MANAGEMENT FORMULA 60.00 45.00
w/COFFEEGENIC
TM
GREEN COFFEE EXTRACT
BLUEBERRY FLAVOR - 414 grams powder
01694 CALORIE CONTROL WEIGHT MANAGEMENT FORMULA 64.00 48.00
w/COFFEEGENIC GREEN COFFEE EXTRACT
BLUEBERRY FLAVOR - 60 individual packs
00118 CAPSULE FILLER MACHINE FOR 00 CAPSULES 18.95 14.21
Buy 4 machines, price each 18.25 13.69
00613 CAPSULE FILLER MACHINE FOR 0 CAPSULES 18.95 14.21
Buy 4 machines, price each 18.25 13.69
01700 CARDIO PEAK
TM
W/STANDARDIZED HAWTHORN & ARJUNA - 120 veg. caps 36.00 27.00
00916 CARNITINE w/GLYCOCARN
(OPTIMIZED) - 60 veg. caps 36.00 27.00

01532 L-CARNITINE - 500 mg, 30 veg. caps 15.00 11.25
01719 L-CARNITINE POWDER NATURAL LEMON FLAVOR - 114 grams 28.00 21.00
01258 CARNOSOOTHE w/PICROPROTECT
TM
- 60 veg. caps 29.95 22.46
01687 CARNOSINE (SUPER) - 500 mg, 90 veg. caps 66.00 49.50
01003 CAT MIX - 100 grams powder 15.00 11.25
01659 CDP CHOLINE CAPS - 250 mg, 60 veg. caps 36.00 27.00
00998 CELL SENSOR-EMF DETECTION METER 39.95 29.95
01370 CHILDRENS FORMULA LIFE EXTENSION MIX
TM
- 100 chewable tablets 18.00 13.50
00550 CHLORELLA - 500 mg, 200 tablets 23.50 17.63
01571 CHLOROPHYLLIN w/ZINC - 100 mg, 100 veg. caps 24.00 18.00
01359 CHO-LESS
TM
- 90 capsules 32.50 24.38
00541 CHOLINE CHLORIDE - 16 oz liquid 12.95 9.71
To order call: 1.954.766.8433 or 1.800.544.4440
Each Each
Each Each
C CONTINUED
01431 COQ10 w/ENH MITOCHONDRIAL SUPPORT(SUPER UBIQUINOL)-200 mg, 30 softgels $62.00 $46.50
01397 CORDYCEPS CS-4
TM
- 60 veg. caps 29.99 22.49
01053 CORIOLUS SUPER STRENGTH - 600 mg, 150 veg. caps 99.95 74.96
80140 COSMESIS ADVANCED UNDER EYE SERUM w/STEM CELLS - .33 oz 49.00 36.75
80139 COSMESIS AMBER SELF MICRODERMABRASION - 2 oz 49.00 36.75
80118 COSMESIS ANTI-AGING MASK - 2 oz 72.00 54.00
80134 COSMESIS ANTI-GLYCATION SERUM - 1 oz 33.00 24.75
W/BLUEBERRY & POMEGRANATE EXTRACTS
80133 COSMESIS ANTIOXIDANT FACIAL MIST - 2 oz 32.00 24.00
80127 COSMESIS ANTIOXIDANT REJUVENATING FOOT CREAM - 2 oz 45.00 33.75
80128 COSMESIS ANTIOXIDANT REJUVENATING FOOT SCRUB - 2 oz 59.00 44.25
80117 COSMESIS ANTIOXIDANT REJUVENATING HAND CREAM - 2 oz 64.00 48.00
80121 COSMESIS ANTIOXIDANT REJUVENATING HAND SCRUB - 2 oz 58.00 43.50
80105 COSMESIS ANTI-REDNESS & BLEMISH LOTION - 1 oz 74.50 55.88
80147 COSMESIS BIOFLAVONOID CREAM - 1 oz jar 46.00 34.50
Buy 2 jars, price each 39.00 29..25
80144 COSMESIS BROCCOLI SPROUT CREAM - 1 oz 46.00 34.50
80120 COSMESIS CORRECTIVE CLEARING MASK - 2 oz 64.50 48.38
80141 COSMESIS DNA REPAIR CREAM - 1 oz jar 49.00 36.75
80108 COSMESIS ESSENTIAL PLANT LIPIDS REPARATIVE SERUM - 1 oz 74.95 56.21
80123 COSMESIS FACE REJUVENATING ANTIOXIDANT CREAM - 2 oz 69.50 52.13
80107 COSMESIS FINE LINE-LESS - 1 oz 74.50 55.88
80131 COSMESIS HAIR SUPPRESS FORMULA - 4 oz 59.00 44.25
80137 COSMESIS HEALING FORMULA ALL-IN-ONE CREAM - 1 oz 53.00 39.75
80115 COSMESIS HEALING MASK - 2 oz 64.50 48.38
80102 COSMESIS HEALING VITAMIN K CREAM - 1 oz 79.50 59.63
80109 COSMESIS HYALURONIC FACIAL MOISTURIZER - 1 oz 58.00 43.50
80110 COSMESIS HYALURONIC OIL-FREE FACIAL MOISTURIZER - 1 oz 58.00 43.50
80138 COSMESIS HYDRATING ANTI-OXIDANT FACE MIST - 4 oz $39.95 $29.96
80103 COSMESIS LIFTING & TIGHTENING COMPLEX - 1 oz 74.50 55.88
Buy 2 tubes, price each 65.56 49.17
80146 COSMESIS LYCOPENE CREAM - 1 oz jar 28.00 21.00
80135 COSMESIS MELATONIN CREAM - 1 oz 33.00 24.75
80114 COSMESIS MILD FACIAL CLEANSER - 8 oz 59.00 44.25
80122 COSMESIS NECK REJUVENATING ANTIOXIDANT CREAM - 2 oz 64.00 48.00
80111 COSMESIS PIGMENT CORRECTING CREAM - 1/2 oz 74.00 55.50
80106 COSMESIS REJUVENATING SERUM - 1 oz 74.50 55.88
80142 COSMESIS RESVERATROL ANTI-OXIDANT SERUM - 1 oz 46.00 34.50
80112 COSMESIS SKIN LIGHTENING SERUM - 1/2 oz 85.00 63.75
80130 COSMESIS SKIN STEM CELL SERUM - 1 oz 74.00 55.50
80143 COSMESIS STEM CELL CREAM W/ALPINE ROSE - 1 oz jar 66.00 49.50
80148 COSMESIS TIGHTENING & FIRMING NECK CREAM - 2 oz jar 39.00 29.25
80116 COSMESIS ULTRA LIP PLUMPER - 1/3 oz 64.00 48.00
80101 COSMESIS ULTRA WRINKLE RELAXER - 1 oz 89.95 67.46
80113 COSMESIS UNDER EYE REFINING SERUM - 1/2 oz 74.50 55.88
80104 COSMESIS UNDER EYE RESCUE CREAM - 1/2 oz 74.50 55.88
80129 COSMESIS VITAMIN C SERUM - 1 oz 85.00 63.75
80136 COSMESIS VITAMIN D LOTION - 4 oz 36.00 27.00
80145 COSMESIS VITAMIN E-ESSENTIAL CREAM - 1 oz 28.00 21.00
00862 CRAN-MAX
- 500 mg, 60 veg. caps 17.50 13.13

01424 CRAN-MAX
with UTIROSE
TM
(OPTIMIZED) - 60 veg. caps 18.00 13.50
01529 CREATINE CAPSULES - 120 veg. caps 10.95 8.21
01646 CREATINE WHEY GLUTAMINE POWDER - 454 grams (vanilla) 30.00 22.50
01429 CR MIMETIC LONGEVITY FORMULA - 60 veg. caps 39.00 29.25
*33840 CRWAY GREAT GLUCOSE CONTROL CD 98.00 82.00
**CRWAY CR WAY OPTIMAL HEALTH PROGRAM SOFTWARE 195.00 195.00
Each Each
Each Each
00407 CURCUMIN
(SUPER BIO) - 400 mg, 60 veg. caps $38.00 $28.50

01313 DERMAWHEY- 400 mg, 60 caps 65.00 48.75
00658 7-KETO
DHEA METABOLITE - 25 mg, 100 caps 28.00 21.00

01479 7-KETO
DHEA METABOLITE - 100 mg, 60 veg. caps 40.00 30.00

01640 DHA (VEGETARIAN SOURCED) - 200 mg, 30 veg. softgels 20.00 15.00
00607 DHEA - 25 mg, 100 tablets (dissolve in mouth) 14.00 10.50
01478 DHEA COMPLETE - 60 veg. caps 48.00 36.00
00335 DHEA - 25 mg, 100 caps 18.00 13.50
00454 DHEA - 15 mg, 100 caps 14.00 10.50
00882 DHEA - 50 mg, 60 caps 19.00 14.25
01689 DHEA - 100 mg, 60 veg. caps 24.00 18.00
01358 DIGEST RC - 30 tablets 19.95 14.96
01272 DIGESTIVE ENZYMES (ENHANCED SUPER) - 100 veg. caps 18.95 14.21
01671 D,L-PHENYLALANINE CAPSULES - 500 mg, 100 veg. caps 18.75 14.06
01540 DMAE BITARTRATE - 150 mg, 200 veg. caps 18.00 13.50
00059 DMG - 125 mg, 60 tablets 22.80 17.10
01570 DNA PROTECTION FORMULA - 60 veg. caps 34.00 25.50
00544 DOG MIX - 100 grams powder 19.50 14.63
00321 DR. PROCTORS ADVANCED HAIR FORMULA - 2 oz 39.95 29.96
00320 DR. PROCTORS HAIR FORMULA SHAMPOO - 8 oz 24.95 18.71
00899 DUAL-ACTION MICRODERMABRASION ADV. EXFOLIATE - 2.4 oz 39.95 29.96
01672 DUAL-C - 90 veg. caps 12.00 9.00
E
01528 ECHINACEA EXTRACT - 250 mg, 60 veg. caps $14.35 $10.76
01498 ENDOTHELIAL DEFENSE w/FULL-SPECTRUM POMEGRANATE - 60 softgels 56.00 42.00
00997 ENDOTHELIAL DEFENSE
TM
w/GLISODIN
- 60 veg. caps 52.00 39.00

00625 EPA/DHA (MEGA) - 120 softgels 19.95 14.96
01042 EUROPEAN LEG SOLUTION DIOSMIN 95 - 600 mg, 30 veg. tabs $20.00 $15.00
01706 EXTRAORDINARY ENZYMES - 60 caps 26.00 19.50
01514 EYE PRESSURE SUPPORT w/MIRTOGENOL
- 30 veg. caps 38.00 28.50

F

01054 FACE MASTER
PLATINUM $199.00 $199.00

00965 FAST-ACTING JOINT FORMULA - 30 caps 39.00 29.25
20053 FEM DOPHILUS
- 30 caps 25.95 19.46

20055 FEM DOPHILUS
- 60 caps 39.95 29.96

01064 FEMMENESSENCE MACAPAUSE
- 120 veg. caps 34.99 26.24

01311 FERNBLOCK
w/SENDARA
(ENHANCED) - 30 veg. caps 39.00 29.25

01670 FIBER FOOD CAPS - 200 veg. caps 16.00 12.00
00718 FIBRINOGEN RESIST
TM
- 30 veg. caps 49.00 36.75
00873 FLAXSEED POWDER (HI-LIGNAN
NUTRI-FLAX
) - 16 oz powder 9.95 7.46

01439 FOLATE (OPTIMIZED) (L-METHYLFOLATE) 1000 mcg - 100 veg. caps 28.00 21.00
01641 FOLIC ACID + B12 CAPSULES - 200 veg. caps 10.50 7.88
00300 FORSKOLIN - 10 mg, 60 caps 15.00 11.25
01513 FUCOIDAN w/MARITECH
926 (OPTIMIZED) - 60 veg. caps 36.00 27.00

00993 FUCOXANTHIN-SLIM
TM
- 90 softgels 44.00 33.00
G
00559 GAMMA E TOCOPHEROL/TOCOTRIENOLS - 60 softgels $42.00 $31.50
00759 GAMMA E TOCOPHEROL W/SESAME LIGNANS - 60 softgels 32.00 24.00
01394 (OPTIMIZED) GARLIC - 200 veg. caps 24.95 18.71
01301 GH PITUITARY SUPPORT DAY FORMULA - 120 vegetarian tabs 48.00 36.00
01302 GH PITUITARY SUPPORT NIGHT FORMULA - 120 veg. caps 25.00 18.75
01228 GINGER FORCE - 60 softgels 29.95 22.46
01658 GINKGO BILOBA CERTIFIED EXTRACT
TM
- 120 mg, 365 veg. caps 46.00 34.50
01648 GINKGO EXTRACT 28/7 (SUPER) - 120 mg, 100 veg. caps 29.00 21.75
01032 (PANAX RED) GINSENG - 60 veg. caps 29.99 22.49
00756 GLA WITH SESAME LIGNANS (MEGA) - 60 softgels 19.50 14.63
00345 (L) GLUTAMINE CAPSULES - 500 mg, 100 caps 14.95 11.21
To order call: 1.954.766.8433 or 1.800.544.4440
Each Each
Each Each
G CONTINUED
00141 (L)-GLUTAMINE POWDER - 100 grams $22.00 $16.50
00522 GLUCOSAMINE/CHONDROITIN CAPSULES - 100 caps 38.00 28.50
01541 GLUTATHIONE, CYSTEINE & C - 100 veg. caps 20.00 15.00
00314 L-GLUTATHIONE (MEGA) - 250 mg, 60 caps 39.64 29.73
01669 GLYCINE - 1,000 mg, 100 veg. caps 12.00 9.00
01091 GRAPE EXTRACT w/RESVERATROL (WHOLE) - 60 veg. caps 36.00 27.00
01411 GRAPE SEED EXTRACT w/RESVERATROL & PTEROSTILBENE - 100 mg, 60 veg. caps 36.00 27.00
01604 GREEN COFFEE EXTRACT COFFEEGENIC
TM
- 200 mg, 90 veg. caps 25.00 18.75
01620 GREEN COFFEE EXTRACT COFFEEGENIC
TM
- 400 mg, 90 veg. caps 38.00 28.50
00953 GREEN TEA EXTRACT (MEGA) - lightly caffeinated - 100 veg. caps 28.00 21.00
00954 GREEN TEA EXTRACT (MEGA) - decaffeinated - 100 veg. caps 28.00 21.00
H
01074 5 HTP - 100 mg, 60 caps $27.95 $20.96
01675 HCA - 90 veg. caps 18.00 13.50
01629 HEAROS
TM
EAR PLUGS - 1 pack - regular size 14.00 10.50
01635 HEAROS
TM
EAR PLUGS - 1 pack - small size 14.00 10.50
01393 HEPATOPRO - 900 mg, 60 softgels 50.00 37.50
01435 HOMOCYSTEINE RESIST - 100 caps 24.00 18.00
01527 HUPERZINE A - 200 mcg, 60 veg caps 40.00 30.00
00661 HYDRODERM
- 1 oz 79.95 59.96
I
*01060 i26
HYPERIMMUNE EGG - 140 grams powder $49.99 $42.00

*01319 i26
HYPERIMMUNE EGG - 135 capsules 31.99 25.59

*01318 i26
HYPERIMMUNE EGG CHEWABLES - (vanilla) 45 tablets 31.99 25.59

00955 IMMUNE PROTECT W/PARACTIN
- 30 veg. caps 29.50 22.13

01049 INNERPOWER
TM
- 555 grams powder 42.00 31.50
01674 INOSITOL CAPSULES - 1000 mg, 360 veg. caps 52.00 39.00
01292 INTEGRA-LEAN
AFRICAN MANGO IRVINGIA - 150 mg, 60 veg. caps 28.00 21.00

01002 IODORAL
- 180 tabs 50.00 37.50

01677 IRON PROTEIN PLUS - 300 mg, 100 veg. caps 28.00 21.00
01492 IRVINGIA W/PHASE 3
TM
- 120 veg. caps 56.00 42.00
CALORIE CONTROL COMPLEX (0PTIMIZED AFRICAN MANGO)
J, K
00056 JARRO-DOPHILUS EPS
TM
- 60 veg. caps $21.95 $16.46
01387 JARRO-DOPHILUS ORAL PROBIOTIC GUM - Pom-Berry avor, 8 pieces 4.95 3.71
01388 JARRO-DOPHILUS ORAL PROBIOTIC LOZENGE - Pom-Berry avor, 8 pieces 4.95 3.71
01724 K w/ADVANCED K2 COMPLEX (SUPER) - 90 softgels 30.00 22.50
01600 KRILL HEALTHY JOINT FORMULA - 30 softgels 32.00 24.00
01050 (NKO) KRILL OIL - 60 softgels 33.95 25.46
00316 KYOLIC
GARLIC FORMULA 102 - 200 caps 26.45 19.84

00214 KYOLIC
GARLIC FORMULA 105 - 200 caps 27.45 20.59

00789 KYOLIC
RESERVE - 600 mg, 120 caps 27.95 20.96

L
01681 LACTOFERRIN (APOLACTOFERRIN) CAPS - 60 caps $48.00 $36.00
00017 LAVILIN UNDERARM DEODORANT - 12.5 grams cream 16.99 12.74
00020 LECITHIN - 16 oz. granules 15.00 11.25
01755 LIFE EXTENSION MIX
TM
- 315 tablets 98.00 73.50
TM
W/EXTRA NIACIN - 315 tablets 98.00 73.50
TM
- 490 caps 110.00 82.50
TM
POWDER - 14.81 oz 98.00 73.50
TM
- 315 tablets w/o copper 98.00 73.50
TM
W/EXTRA NIACIN 315 tablets w/o copper 98.00 73.50
TM
- 490 caps w/o copper 110.00 82.50
TM
POWDER - 14.81 oz w/o copper 98.00 73.50
00263 LIFE FLORA
TM
- 300 mg, 120 caps 20.50 15.38
01608 LIVER EFFICIENCY FORMULA- 30 veg. caps 18.00 13.50
01639 5-LOX INHIBITOR W/APRESFLEX
TM
- 100 mg, 60 veg. caps 22.00 16.50
Each Each
Each Each
01678 L-LYSINE - 620 mg, 100 veg. caps $9.00 $6.75
01470 LURALEAN
CAPS SPECIAL PROPOLMANNAN 28.00 21.00

PARTICLE SIZE - 120 veg. caps
00455 LYCOPENE EXTRACT (MEGA) - 15 mg, 90 softgels 35.00 26.25
M
01369 MAGNESIUM CAPS - 500 mg, 100 veg. caps $10.00 $7.50
01682 MAGNESIUM CITRATE - 160 mg, 100 veg. caps 9.00 6.75
01668 MELATONIN - 300 mcg, 100 veg. caps 5.75 4.31
01083 MELATONIN - 500 mcg, 200 veg. caps 18.00 13.50
00329 MELATONIN - 1 mg, 60 caps 5.00 3.75
01086 MELATONIN - 3 mg, 60 time-release caps 10.50 7.88
00332 MELATONIN - 3 mg, 60 veg. lozenges 8.00 6.00
01087 MELATONIN TIME RELEASE - 300 mcg, 100 veg. caps 6.25 4.69
01788 MELATONIN TIME RELEASE - 750 mcg, 60 veg. tablets 8.00 6.00
01009 MEMORY UPGRADE
TM
- 600 grams powder 26.95 20.21
01536 METHYLCOBALAMIN - 1 mg, 60 lozenges (vanilla) 9.95 7.46
01537 METHYLCOBALAMIN - 5 mg, 60 lozenges (vanilla) 32.00 24.00
00709 MIGRA-EEZE
TM
(BUTTERBUR) - 60 softgels 29.50 22.13
01522 MILK THISTLE (CERTIFIED EUROPEAN) - 750 mg, 60 veg. caps 34.00 25.50
01517 MILK THISTLE (CERTIFIED EUROPEAN) - 120 veg. caps 52.00 39.00
01698 MIRAFORTE w/STANDARDIZED LIGNANS (SUPER) - 120 caps 62.00 46.50
01569 MITOCHONDRIAL BASICS w/BIOPQQ
TM
- 30 caps 52.00 39.00
01568 MITOCHONDRIAL ENERGY OPTIMIZER w/BIOPQQ
TM
- 120 caps 94.00 70.50
00803 MIST ORAL III w/COQ10 - 2 oz 28.00 21.00
00065 MK-7 - 90 mcg, 60 softgels 28.00 21.00
01279 MOUTHWASH W/POMEGRANATE - 16 oz $18.50 $13.88
00451 MSM (METHYLSULFONYLMETHANE) - 1000 mg, 100 caps 14.00 10.50
N
01534 N-ACETYL-L-CYSTEINE - 600 mg, 60 veg. caps $14.00 $10.50
00066 NATTOKINASE - 60 softgels 25.50 19.13
00891 NATURAL APPETITE CONTROL - 90 softgels 28.00 21.00
00984 NATURAL BP MANAGEMENT - 60 tablets 42.00 31.50
00913 NATURAL ESOPHAGUARD - 10 softgels 19.95 14.96
01692 NATURAL ESTROGEN w/POMEGRANATE EXTRACT - 60 caplets 38.00 28.50
01221 NATURAL FEMALE SUPPORT - 30 veg. caps 28.00 21.00
01471 NATURAL GLUCOSE ABSORPTION CONTROL - 60 veg. caps 39.00 29.25
00698 NATURAL RELIEF 1222
TM
- 2 oz 28.00 21.00
01626 NATURAL SEX FOR WOMEN
50+ (ADVANCED) - 90 veg. caps 59.00 44.25

01084 NATURAL SLEEP
- 3 mg, 60 veg. caps 12.99 9.74

01507 NATURAL SLEEP
(ENHANCED) W/ MELATONIN - 30 caps 22.00 16.50

01511 NATURAL SLEEP
(ENHANCED) W/O MELATONIN - 30 caps 20.00 15.00

01085 NATURAL SLEEP MELATONIN
- 5 mg, 60 caps 18.00 13.50

00987 NATURAL STRESS RELIEF - 30 veg. caps 28.00 21.00
01603 NEURO-MAG
TM
MAGNESIUM L-THREONATE - 90 veg. caps 40.00 30.00
01602 NEURO-MAG
TM
L-THREONATE W/CALCIUM & VITAMIN D 40.00 30.00
205 grams - Lemon avor
00373 NO-FLUSH NIACIN - 800 mg, 100 caps 19.00 14.25
01035 NUTRIM - 225 grams powder 25.95 19.46
O
01623 OLIVE LEAF VASCULAR SUPPORT - 500 mg, 60 veg. caps $22.00 $16.50
01483 OMEGA 3 EPA/DHA w/SESAME LIGNANS & 18.00 13.50
OLIVE FRUIT EXTRACT (SUPER) - 60 softgels
01482 OMEGA 3 EPA/DHA w/SESAME LIGNANS & 32.00 24.00
OLIVE FRUIT EXTRACT (SUPER) - 120 softgels
To order call: 1.954.766.8433 or 1.800.544.4440
Each Each
Each Each
O CONTINUED
01484 OMEGA 3 EPA/DHA W/SESAME LIGNANS & - 120 enteric coated softgels $34.00 $25.50
OLIVE FRUIT EXTRACT (SUPER)
01485 OMEGA 3 EPA/DHA W/SESAME LIGNANS & 20.00 15.00
OLIVE FRUIT EXTRACT (SUPER) - 60 enteric coated softgels
01619 OMEGA 3 EPA/DHA W/SESAME LIGNANS & - 240 softgels 32.00 24.00
OLIVE FRUIT EXTRACT (SUPER) (SMALL SOFTGEL)
01632 OMEGA-3 LEMON WHIRL - 16 oz bottle 24.00 18.00
01633 OMEGA-3 TROPICAL WHIRL - 16 oz bottle 24.00 18.00
01701 ONE-PER-DAY - 60 tablets 22.00 16.50
01328 ONLY TRACE MINERALS - 90 caps 15.00 11.25
00915 OPTIZINC
- 30 mg, 90 veg. caps 5.95 4.46

01070 ORGANIC TOTAL BODY CLEANSE
TM
- 14-day supply 34.99 26.24
P
00073 PANCREATIN - 500 mg, 50 caps $13.22 $9.92
01323 PEAK ATP
WITH GLYCOCARN
- 60 veg. caps 59.00 44.25

00342 PECTA SOL-C
MODIFIED CITRUS PECTIN - 454 grams powder 99.95 74.96

01080 PECTA SOL-C
MODIFIED CITRUS PECTIN - 270 veg. caps 69.95 52.46

00673 PGX SOLUBLE FIBER BLEND (WELLBETX
) -180 caps 34.95 26.21

00865 PHARMAGABA
TM
- 60 chewable tablets 29.95 22.46
01676 PHOSPHATIDYLSERINE CAPS - 100 mg, 100 veg. caps 54.00 40.50
01390 PHOSPHOMEGA
- 60 softgels 39.95 26.96

00561 POLICOSANOL - 10 mg, 60 tablets 24.00 18.00
01423 POMEGRANATE
TM
(FULL-SPECTRUM) - 30 softgels 24.00 18.00
00956 POMEGRANATE EXTRACT - 30 veg. caps 19.50 14.63
00957 POMEGRANATE JUICE CONCENTRATE - 16 oz. liquid 25.95 19.46
00577 POTASSIUM IODIDE - 1 box, 14 tablets 6.95 5.21
01500 PQQ CAPS W/BIOPQQ
TM
- 10 mg, 30 veg. caps 24.00 18.00
01647 PQQ CAPS W/BIOPQQ
TM
- 20 mg, 30 veg. caps 40.00 30.00
00302 PREGNENOLONE - 50 mg, 100 caps $26.00 $19.50
00700 PREGNENOLONE - 100 mg, 100 caps 28.00 21.00
***01373 PRELOX
NATURAL SEX FOR MEN
- 60 tablets 52.00 39.00

00571 PRIMAL DEFENSE
TM
- 90 caplets 49.95 37.46
01329 PROBIOTIC ALL-FLORA
- 60 veg. caps 25.95 19.46

01326 PROBIOTIC ANTI-AGING
TM
- 90 veg. caps 30.95 23.21
00525 PROBOOST THYMIC PROTEIN A
TM
- 4 mcg, 30 packets 59.95 44.96
01441 PROGESTACARE FOR WOMEN - 4 oz cream 34.95 26.21
01020 PROGREENS
- 15 stick pack 22.50 16.88

01072 PRO-M INTERNAL DEODORIZER - 500 mg, 100 veg. caps 28.00 21.00
01695 PROSTATE FORMULA W/APRESFLEX
TM
STAND. LIGNANS (ULTRA NAT) 60 softgels 38.00 28.50
01642 PROTEIN - VANILLA - (Enhanced Life Extension) -1 lb. powder 30.00 22.50
01643 PROTEIN - CHOCOLATE - (Enhanced Life Extension) - 1 lb. powder 30.00 22.50
01508 PTEROPURE - 50 mg Pterostilbene 60 veg. caps 32.00 24.00
01075 PURE PLANT PROTEIN - Natural Vanilla 450 grams powder 36.00 27.00
01209 PUMPKIN SEED EXTRACT (WATER-SOLUBLE) - 60 veg. caps 20.00 15.00
01210 PUMPKIN SEED EXT w/SOY ISOFLAVONES (WATER-SOLUBLE)- 60 veg. caps 22.00 16.50
01637 PYCNOGENOL
FRENCH MARITIME PINE BARK EXTRACT-100 mg, 60 veg. caps 64.00 48.00
01217 PYRIDOXAL 5-PHOSPHATE - 100 mg, 60 veg. caps 22.00 16.50
Q, R
01309 QUERCETIN (OPTIMIZED) - 250 mg, 60 veg. caps $22.00 $16.50
01030 RED YEAST RICE (Bluebonnet)- 600 mg, 60 veg. caps 17.50 13.13
00979 RED YEAST RICE (Natures Plus)- 600 mg, 60 veg. caps 23.95 17.96
00060 RED YEAST RICE EXTENDED RELEASE - 30 veg. tablets 21.50 16.13
00605 REGIMINT - 60 enteric-coated caps 19.95 14.96
01708 REISHI EXTRACT MUSHROOM COMPLEX - 60 veg. caps 30.00 22.50
01448 REJUVENEX
BODY LOTION - 6 oz 24.00 18.00

00918 REJUVENEX
FACTOR - 1.7 oz airless pump 65.00 48.75

Each Each
Each Each
SUB-TOTAL OF COLUMN 1 SUB-TOTAL OF COLUMN 1 SUB-TOTAL OF COLUMN 16 SUB-TOTAL OF COLUMN 15
01621 REJUVENEX
FACTOR FIRMING SERUM - 1.7 oz $65.00 $48.75

01220 REJUVENEX
(ULTRA) - 2 oz 52.00 39.00

00676 REJUVENIGHT
(ULTRA) - 2 oz 39.95 29.96

01413 RESVERATROL W/PTEROSTILBENE - 20 mg, 60 veg. caps 24.00 18.00
01410 RESVERATROL W/PTEROSTILBENE - 100 mg, 60 veg. caps 36.00 27.00
01430 RESVERATROL w/SYNERGISTIC 46.00 34.50
GRAPE-BERRY ACTIVES (OPTIMIZED) - 250 mg, 60 veg. caps
00889 RHODIOLA EXTRACT - 250 mg, 60 veg. caps 11.75 8.81
00972 (D) RIBOSE POWDER - 150 grams 27.50 20.63
01473 (D) RIBOSE TABLETS - 100 veg. tabs 32.00 24.00
01609 RICH REWARDS
TM
BREAKFAST GROUND COFFEE - 12 oz. bag 13.00 9.75
01610 RICH REWARDS
TM
DECAFFEINATED ROAST GROUND COFFEE - 12 oz. bag 14.00 10.50
01712 RICH REWARDS
TM
BLACK BEAN VEGETABLE SOUP - 32 oz. bottle 13.00 9.75
01530 RICH REWARDS
TM
CRUCIFEROUS VEGETABLE SOUP - 32 oz. bottle 11.95 8.96
01531 RICH REWARDS
TM
(SPICY) CRUCIFEROUS VEGETABLE SOUP - 32 oz. bottle 11.95 8.96
01705 RICH REWARDS
TM
LENTIL VEGETABLE SOUP - 32 oz. bottle 13.00 9.75
01208 R-LIPOIC ACID (SUPER) - 300 mg, 60 veg. caps 49.00 36.75
00070 RNA CAPSULES - 500 mg, 100 caps 17.95 13.46
00917 ROSMARINIC ACID EXTRACT - 60 veg. caps 59.00 44.25
S
01432 SAFFRON w/SATIEREAL (OPTIMIZED) - 60 veg. caps $36.00 $27.00
00358 SAME (S-ADENOSYL-METHIONINE) - 200 mg, 20 enteric coated tablets 16.00 12.00
01543 SEA-IODINE - 1000 mcg, 60 caps 8.00 6.00
00046 SELENIUM - 2 oz dropper bottle 9.95 7.46
01679 SE-METHYL L-SELENOCYSTEINE - 200 mcg, 100 veg. caps $12.00 $9.00
00318 SERRAFLAZYME - 100 tablets 18.00 13.50
00284 SHARK LIVER OIL (NORWEGIAN) - 1000 mg, 30 softgels 18.00 13.50
01684 SILYMARIN - 100 mg, 50 veg. caps 9.25 6.94
01596 SKIN RESTORING PHYTOCERAMIDES w/LIPOWHEAT
TM
- 30 veg. liquid caps 25.00 18.75
00961 SODZYME
w/GLISODIN
AND WOLFBERRY - 90 veg. caps 28.00 21.00

00657 SOLARSHIELD SUNGLASSES - 1 pair smoke color 12.99 9.74
Buy 2 pairs, price each 11.50 8.63
01099 STABILIUM
200 - 30 caps 30.00 22.50

00432 STEVIA EXTRACT - 100 packets, 1 gram each 9.95 7.46
01396 ST. JOHNS WORT EXTRACT - 300 mg, 60 veg. caps 10.98 8.24
01476 STRONTIUM - 750 mg, 90 veg. caps 20.00 15.00
00747 SUNGLASSES (OVERXCAST POLARIZED) - gray color, large 27.00 20.25
00748 SUNGLASSES (OVERXCAST POLARIZED)- gray color, medium 27.00 20.25
01649 SUPER ABSORBABLE SOY ISOFLAVONES - 60 veg. caps 28.00 21.00
01408 SUPER SAW PALMETTO/NETTLE ROOT W/BETA-SITOSTEROL - 60 softgels 28.00 21.00
01407 SUPER SAW PALMETTO W/BETA-SITOSTEROL - 30 softgels 15.00 11.25
01778 SUPER SELENIUM COMPLEX - 200 mcg, 100 veg. caps 14.00 10.50
00674 SYTRINOL
TM
- 60 softgels 32.00 24.00
T
5"-t4)*
TM
COSMETICS |u| i|lu||+|iu| (le+:e c+ll
1-800-544-4440 or visit www.LifeExtension.com
01062 TART CHERRY - 600 mg, 60 caps $18.95 $14.21
00199 TAURINE - 1000 mg, 50 caps 8.95 6.71
00133 TAURINE POWDER - 300 grams 20.00 15.00
01304 THEAFLAVIN STANDARDIZED EXTRACT - 30 veg. caps 18.00 13.50
01683 (L) THEANINE - 100 mg, 60 veg. caps 24.00 18.00
01038 THERALAC PROBIOTICS - 30 caps 47.95 35.96

00668 THYROID FORMULA
TM
(METABOLIC ADVANTAGE) - 100 caps 21.95 16.46
00349 TMG POWDER - 50 grams 14.00 10.50
To order call: 1.954.766.8433 or 1.800.544.4440
Each Each
Each Each
T CONTINUED
00359 TMG - 500 mg, 180 tablets $18.00 $13.50
00781 TOCOTRIENOLS WITH SESAME LIGNANS - 60 softgels 38.00 28.50
01400 TOCOTRIENOLS (SUPER-ABSORBABLE) - 60 softgels 30.00 22.50
01278 TOOTHPASTE - 4 oz (Mint) 9.50 7.13
01274 TOTAL SUN PROTECTION CREAM W/BETA GLUCAN - 4 oz 28.00 21.00
01468 TRIPLE ACTION CRUCIFEROUS VEGETABLE EXTRACT - 60 veg. caps 24.00 18.00
01469 TRIPLE ACTION CRUCIFEROUS VEGETABLE EXTRACT 32.00 24.00
W/RESVERATROL -60 veg. caps
01386 TRUFIBER
- 180 grams 32.95 24.71

01389 TRUFLORA PROBIOTICS & ENZYMES - 32 veg. caps 42.95 32.21
01716 TWO-PER-DAY - 60 tablets 10.50 7.88
01715 TWO-PER-DAY - 120 tablets 20.00 15.00
01714 TWO-PER-DAY - 120 caps 22.00 16.50
00326 L-TYROSINE - 500 mg, 100 tablets 12.98 9.74
V
00213 VANADYL SULFATE - 7.5 mg, 100 tablets $15.00 $11.25
00408 VENOTONE - 60 caps 18.95 14.21
01327 VINPOCETINE - 10 mg, 100 tablets 18.00 13.50
01219 VITAMIN A NUTRISORB - 0.6 oz 27.00 20.25
01526 VITAMIN B3 NIACIN - 1,000 mg, 100 veg. caps 12.75 9.56
00372 VITAMIN B3 NIACIN - 500 mg, 100 caps 7.65 5.74
00098 VITAMIN B5 - 500 mg, 100 caps (Pantothenic Acid) 10.50 7.88
01535 VITAMIN B6 - 250 mg, 100 veg. caps 12.50 9.38
00361 VITAMIN B12 - 500 mcg, 100 lozenges 8.75 6.56
01634 VITAMIN C w/ DIHYDROQUERCETIN - 1000 mg, 60 tablets 10.00 7.50
00927 VITAMIN C w/ DIHYDROQUERCETIN - 1000 mg, 250 tablets 25.50 19.13
00084 VITAMIN C (BUFFERED) POWDER - 454.6 grams 23.95 17.96
00864 VITAMIN D3 - 2000 IU, 1 oz 28.00 21.00
01753 VITAMIN D3 - 1000 IU, 90 softgels $7.00 $5.25
01751 VITAMIN D3 - 1000 IU, 250 softgels 12.50 9.38
01573 VITAMIN D3 w/SEA-IODINE - 5000 IU, 60 caps 14.00 10.50
01572 VITAMINS D AND K w/SEA-IODINE - 60 caps 24.00 18.00
01663 VITAMIN E (PURE NATURAL) - 400 IU, 100 veg. caps 30.00 22.50
01225 VITAMIN K2 (LOW-DOSE) - 45 mcg, 90 softgels 18.00 13.50
Z
01686 ZEAXANTHIN w/LUTEIN & MESO-ZEAXANTHIN $42.00 $31.50
PLUS ASTAXANTHIN AND C3G (SUPER) - 60 softgels

01685 ZEAXANTHIN w/LUTEIN & MESO-ZEAXANTHIN 22.00 16.50
AND C3G (SUPER) - 60 softgels

00061 ZINC LOZENGES - 75 lozenges 9.50 7.13
01051 ZYFLAMEND
WHOLE BODY - 120 softgels 60.95 45.71

* These products are not 25% off retail price.
** Not eligible for member discount or member
renewal product credit.
*** Due to license restrictions, this product is
not for sale to customers outside of the USA.

Member pricing not valid on this item.

Due to license restrictions, this product is
not for sale to Canada.
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LIFE EXTENSION MEDIA
33855 POWER FOODS FOR THE BRAIN |] |e+l . B+||+|, | 2O1J $26.99 $2O.24
JJ854 THE GREAT CHOLESTEROL MYTH |] 1u||] BuWe|, ||, C|S +| S|e(|e| Si|+||+, | 2O12 $19.99 $14.99
33853 SMART, STRONG AND SEXY AT 100 |] +.i |e|ic| 2O12 $1I.95 $1J.46
JJ852 THE MAGIC OF CHOLESTEROL NUMBERS |] |. Se|e] u+| 2O12 $29.95 $22.46
JJ848 YOUR BEST INVESTMENT SECRETS TO A HEALTHY BODY AND MIND |] |Wi| |ee, | 2O12 $24.95 $18.I1
JJ84I THE FATIGUE SOLUTION |] |. |.+ CW]|+| 2O12 $24.95 $18.I1
JJ844 ABUNDANCE: THE FUTURE IS BETTER THAN YOU THINK |] S|e.e| |u|le| +| |e|e|e i+|+|i: 2O12 $26.99 $2O.24
JJ84J BOMBSHELL |] Su+||e Su|e|: 2O12 $26.OO $19.5O
JJ845 DRUG MUGGERS |] R.||. Su:] Cu|e| 2O12 $21.99 $16.49
JJ842 HEART ATTACK PROOF |] |ic|+el 0|e|, | 2O12 $19.95 $14.96
33835 PHARMOCRACY |] willi+| |+luu| 2O11 $24.OO $9.6O
Bu] 4 |uu|:, (|ice e+c| $8.OO
JJ8J9 THE GOLDEN RATIO LIFESTYLE DIET |] Ru|e|| ||ie|+|, |, +| |+|||eW C|u:: 2O12 $19.95 $14.96
33838 YOUR GUIDE TO HEALTHY SKIN THE NATURAL WAY |] +|] ull+e|, | 2O12 $26.OO $15.OO
JJ8JI WHEAT BELLY |] willi+| +.i:, | 2O11 $25.99 $19.49
33833 THE LIFE PLAN |] 1ell|] S. |ile, |, || 2O11 $26.OO $19.5O
JJ8J2 YOUR BONES |] |+|+ |iu||u, |A, ||! 2O11 $12.OO $9.OO
JJ829 THE IMMORTALITY EDGE |] |ic|+el |u::el, |, ||, |e|+ Bl+c||u||, +.i wu]|+|uW:|i, | 2O11 $25.95 $18.1I
JJ825 THE EMPOWERED PATIENT |] |li+|e|| Cu|e| 2O1O $15.OO $1O.5O
JJ824 VITAMIN D SOLUTION |] |ic|+el |. |ulic|, ||, | 2O1O $25.95 $18.1I
JJ822 BREAKTHROUGH: EIGHT STEPS TO WELLNESS |] Su+||e Su|e|: ((+(e||+c|) 2O1O $15.OO $1O.5O
JJ8J6 WEIGHT LOSS GUIDE |] S|e.e| V. 1u]+l, | +| willi+| |+luu| (|+|cu.e|) (J| |i|iu|) 2O1O $29.95 $8.99
JJ816 FDA: FAILURE, DECEPTION, ABUSE |] |ile |/|e|:iu| |uu|+|iu| 2O1O $2O.OO $15.OO
JJ818 STAY YOUNG & SEXY WITH BIO-IDENTICAL HORMONE REPLACEMENT |] 1u|+||+| w|i||, | 2O1O $19.95 $14.96
JJ815 KNOCKOUT |] Su+||e Su|e|: 2OO9 $25.99 $1I.OO
JJ814 CHEATING DEATH |] S+||+] u(|+, | 2OO9 $24.99 $1I.49
JJ812 LIFE OVER CANCER |] |ei|| Bluc|, | (|+|cu.e|) 2OO9 $25.OO $1I.5O
JJ811 THE GREAT AMERICAN HEART HOAX |] |ic|+el 0|e|, |, |ACC, |A|A 2OO9 $24.95 $1I.4I
JJ8O9 TESTOSTERONE FOR LIFE |] A||+|+| |u|e||+le|, | 2OO8 $16.95 $11.8I
JJ8O8 BREAKTHROUGH: EIGHT STEPS TO WELLNESS |] Su+||e Su|e|: 2OO8 $25.95 $18.1I
JJ599 YOUNGER YOU |] ||ic B|+.e||+|, | $24.95 $15.I5
JJ6OO DISEASE PREVENTION AND TREATMENT, EXPANDED FOURTH EDITION (|+|cu.e|) 2OOJ $49.95 $JI.46
||ice (e| |uu| W|e| 4 |uu|: (u|c|+:e $44.OO $JJ.OO
JJ696 LIFE EXTENSION REVOLUTION |] ||ili( |ee |ille|, | ((+(e||+c|) $16.OO $12.OO
JJ8O5 MIAMI MEDITERRANEAN DIET WITH 300 RECIPES |] |ic|+el . 0|e|, |, |ACC, |A|A (|+|cu.e|) 2OO8 $24.95 $16.25
JJ9O6 THE MIGRAINE CURE |] Se|e] u+|, |, || 2OO6 $24.OO $15.6O
JJ68O PRESCRIPTION FOR DISASTER DVD |] +|] |ull 2OO5 $18.OO $12.OO
JJ6IO A PRIMER ON PROSTATE CANCER (2| ei|iu|) |] S|e(|e| B. S||u|, |, +| u||+ |uli+|u 2OO5 $28.95 $21.I1
JJ262 SAVE YOUR SIGHT |] |+|c Ru:e, |/|ic|+el Ru:e, | $1J.99 $8.J5
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JJ828 THE SEXY YEARS |] Su+||e Su|e|: ((+(e||+c|) 2OO4 $15.OO $1O.5O
JJ695 WE BECOME SILENT V |] |e.i| |ille| $24.98 $18.I4
JJ8OJ WHAT YOUR DOCTOR MAY NOT TELL YOU ABOUT DIABETES |] S|e.e| V. 1u]+l, | 2OO8 $14.99 $1O.49
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JJ8O4 YOU: STAYING YOUNG: THE OWNERS MANUAL FOR EXTENDING YOUR WARRANTY |] |e||e| 0, | 2OO8 $26.OO $18.2O
AprsFlex is a trademark of Laila Nutraceuticals exclusively licensed to PL ThomasLaila Nutra LLC.
International patents pending.
ActiFlax is a trademark of Pharma Science Nutrients, Inc., all rights reserved. HMRlignan is a trademark
used under sublicense from Linnea S.A. USPlus and DeepExtract are trademarks of Valensa International
and are used under license. US Patents 6,319,524 & 6,669,968. Not available for export.

Ultra Natural Prostate with AprsFlex and
Standardized Lignans softgels combines cutting-edge
ingredients that have been scientifcally substantiated
to protect the prostate gland and maintain its healthy
function.*
The latest addition to this formula is AprsFlex, an
extract of Boswellia serrata that has been shown in studies
to have two times the bioavailability of the leading
boswellia extract. AprsFlex inhibits the enzyme 5-lipoxy-
genase. Boron is included because of studies showing it
may help slow elevation of prostate-specifc antigen (PSA).
The formula provides saw palmetto extract and
Graminex Flower Pollen Extract to interfere with DHT
activity and help regulate infammatory reactions in
the prostate.* Lycopene is a carotenoid that is included in
the formula to help maintain healthy DNA gene function
in prostate cells.
In order to boost its anti-estrogen capabilities, Ultra
Natural Prostate Formula incorporates HMRLignan,
derived from Norway spruce, fax lignans, and nettle
root extract.
Since normal aging can lead to potentially unsafe levels
of prostaglandins in the prostate, Pygeum africanum
extract is included to help suppress prostaglandins and
thereby promote prostate comfort.* Beta-sitosterol has
been added because it is the most biologically active
component of pygeum and enhances its protective efects.
The retail price for one bottle of Ultra Natural
Prostate Formula with AprsFlex and
Standardized Lignans is $38. If a member
buys four, the price is reduced to $26.25 per
bottle. If a member buys 12 bottles, the price
is reduced to $24 per bottle.
Contains soybeans and corn.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
To order Ultra Natural Prostate
Formula with AprsFlex,
call 1-800-544-4440
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The daily dose of two softgels of
Ultra Natural Prostate Formula with AprsFlex
and Standardized Lignans Formula provides:
USPlus Saw Palmetto (C0
2
DeepExtract) 320 mg
(std to 85%-95% total fatty acids and sterols)
Graminex Flower Pollen Extract 252 mg
AprsFlex (Boswellia serrata) extract 70 mg
Pumpkin seed oil (Cucurbita pepo) extract 200 mg
(standardized to 85% total fatty acids)
Stinging nettle root extract (Urtica dioica) 240 mg
Pygeum extract 100 mg
Lycopene 10 mg
Phytosterol complex 678 mg
(standardized to 26.6% free beta-sitosterol)
Proprietary blend of HMRlignan 20.15 mg
Norway Spruce and ActiFlax Flax Lignan extracts
Boron 3 mg
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THE NEXT
GENERATION OF
PROSTATE
PROTECTION:

ULTRA NATURAL PROSTATE WITH
APRSFLEX
AND STANDARDIZED LIGNANS

Enhanced Night Vision!
EYE
PROTECTION
FORMULA
To order Super Zeaxanthin with Lutein, Meso-Zeaxanthin and C3G,
call 1-800-544-4440 or visit www. LifeExtension.com
References
1. Available at: http://www.aafp.org/afp/20000401/2159.html.
Accessed August 10, 2010.
2. Alt Med Rev. 2000;5(6):553-62.
Maintain Macular Density
The macular pigment is composed of lutein, zeaxanthin, and
meso-zeaxanthin. The density of the macula is essential to proper
vision. Macular density declines naturally over time.
Eating lots of lutein- and zeaxanthin-containing vegetables
can help maintain the structural integrity of the macula. However,
since meso-zeaxanthin is not part of the typical diet, it cannot
be easily replaced. Young people convert lutein into meso-
zeaxanthin inside their macula. Some aging people, however, lose
their ability to convert lutein into meso-zeaxanthin.
The Super Zeaxanthin formula provides zeaxanthin, lutein
and meso-zeaxanthin to help maintain macular density.
Falling down is responsible for 70% of accidental deaths in
older people.
1
Poor lighting conditions are often the culprit.
Fortunately, C3G derived from black currant extract
supports eyesight in dark conditions by promoting the healthy
function of delicate structures within the retina that support
night vision.
2

Super Zeaxanthin contains a potent dose of C3G to nourish
cells throughout the body.

Comprehensive Ocular Protection
in One Daily Softgel
The Super Zeaxanthin formula provides ingredients
that have been shown to promote healthy eyesight. Just one
softgel of Super Zeaxanthin with Lutein, Meso-Zeaxanthin
and C3G provides:
OptiLut, Lutein Plus and MZ 38 mg
Marigold (Tagetes erecta) extract (fower) [free lutein equivalent 10 mg]
Zeaxanthin & Meso-zeaxanthin blend 3.75 mg
[Paprika (capsicum annuum) extract (fruit), OptiLut, Lutein Plus
and MZ Marigold Extract (fower)]
C3G (Cyanidin-3-glucoside) 2.2 mg
[from European black currant (Ribes nigrum) extract (fruit)]
The retail price for a bottle containing
60 softgels of Super Zeaxanthin with
Lutein, Meso-Zeaxanthin and C3G is
$22. If a member buys four bottles, the
price is reduced to $14.85 per bottle.
Item # 01685 Item# 01685
OptiLut
is a registered trademark of NutriScience Innovations, LLC.

LuteinPlus
and MZ
are registered trademarks of Nutriproducts Ltd., 7

Mareet, CB22 5LA, UK, licensed under US Patents 6,218,436 & 6,329,432.

PO BOX 407198
FORT LAUDERDALE, FLORIDA 33340-7198
LifeExtension

Magazine
WHATS INSIDE
Visit us at www.LifeExtension.com
36 FOODS THAT SAFELY
REDUCE BLOOD GLUCOSE
Certain foodsnotably barley and
black beanscan lower blood
glucose levels and help prevent
glycemic-related disorders.
54 SHIELD YOURSELF FROM
ENVIRONMENTAL CANCER RISKS
A huge body of research shows how
cruciferous vegetables neutralize
environmental toxins and can slash
cancer risk by up to 54%.
7 REBUTTAL TO ATTACK
AGAINST FISH OIL
The American Medical Association
questioned if vascular disease
patients should take sh oil. Read
Life Extensions scathing rebuttal to
this fatally awed report.
46 FRAN DRESCHERS
CRUSADE TO END CANCER
TV star Fran Drescher is a cancer
survivor and activist. Drescher founded
an organization to educate Americans
about preventing cancer and to enable
patients to be diagnosed no later than
stage one.
24 ENHANCED ASTAXANTHIN
FOR BETTER ABSORPTION
Astaxanthin traps huge numbers
of free radicals compared to most
other nutrients. A new compound
has been shown to increase the
bio-availability of carotenoids like
astaxanthin nearly 12-fold.
86 REJUVENATE YOUR
AGING NECK
We pay so much attention to our
aging face, but often neglect to
protect our necks delicate tissues
against the damaging effects
of time.

LEF April 2013

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The ULTIMATE Source For New Health And Medical Findings From Around The World April 2013

WHY DOCTORS ARENT CURING HEART DISEASE

VOLUME NINETEEN / NUMBER FOUR Q April 2013

VOLUME NINETEEN / NUMBER FOUR Q APRIL 2013

we value your opinion and welcome feedback.

uses a unique, patented

with UTIRose contain:

Cranberry infused 500 mg

in this formula alone

with UTIRose containing

versus Ocean Spray Cranberry Juice cocktail

is a registered trademark of Bio-Nutra Technologies, LLC.

APRIL 2013 | LIFE EXTENSION | 5

derives from turmeric

Curcumin is neither absorbed nor

are registered trademarks of

Irvingia is protected by U.S. Patent No. 7,537,790.

proprietary extract is a registered trademark of

Japanese scientists developed astaxanthin

Other appealing properties of astaxanthin

Astaxanthin promotes healthy immunity and

If you have any questions on the scientific content

(warfarin) Drug Users

s Super K with Advanced K2

Aging promotes dangerously increased

In addition to nutrients, hormones, and

Barley and black beans are both excellent

Barley and black beans have been shown

Research demonstrates that these food

If you have any questions on the scientific

has created a large selection

mentioned the can-

For more information on Fran Drescher

is a registered trademark of Indena S.p.A.; HMRlignan trademark is used under

is a registered trademark of Archer Daniels Midland company.

Wasabi (Wasabia japonica) powder (rhizome)

Norway spruce (Picea abies) standardized

ax (Linum usitatissimum L.)

oers an advanced, cutting-edge pomegranate

Pomegranate .......................................... 400 mg

is a registered trademark of Verdure Science, Inc.

does not increase testosterone or estrogen

Environmental toxins are a growing prob-

While our bodies contain systems capable

Toxins, radiation, and other forces exert

Phytochemicals from cruciferous vegeta-

Cruciferous components work together

Because many such compounds are inacti-

If you have any questions on the scientific

lemon balm extract used in

combined these two ingredients with the idea of

lemon balm extract

is a registered trademark of Taiyo International,

is protected by US Trademark Registration No. 2,548,957. Cyracos

If you have any questions on the scientific content

Doctors think of an atherosclerotic lesion

Despite thousands of studies validating

Stenting open narrowed coronary arteries

The aging process damages blood vessels,

A review of the scientific literature reveals

Poor health habits and normal aging result

A primary mechanism involved in endothelial

Annual blood testing is critical to identifying