+Evaluation: Pharmacology UY1/FMSB/PHCL200-L2S4 30mars2010 : 60mins Section A: Multiple Choice (Choose the ONE best answer 1.

The name alcohol denotes a social drug. This name is [a] A commercial name [b] A chemical name* [c] A generic name [d] A publicity name [e] A proprietary name 2. Which of the following routes of administration could ensure the fastest delivery of drug to the brain? [a] Oral [b] Sublingual [c] Intraocular [d] Intranasal* [e] Rectal 3. Who could be identified as the father of anti-microbial therapy [a] Alexander Fleming-penicilline

Dexamethasone Which of the following pharmaceutical preparations is suited for ocular administration? Suspension Liquid solution * Emulsion Aerosol Capsulesaz

[b] Banting and Best(insulin) [c] Paul Ehrlich* [d] Louis Pasteur(microbe) [e] Claude Bernard(phisiologie)
4. Which of the following actions could result in the lost of the efficacy of a drug?
[a] Dilution in an inappropriate solvent [b] Failure to administer the drug in right route [c] Inappropriate storage of the drug [d] All of the above * [e] Non of the above Which route of drug administration should be avoided for drugs that undergo extensive first pass metabolism? Intravenous Oral * Intramuscular Rectal Sub-lingual Which of these pharmacokinetics parameters could compare the amount of drug absorbed following administration of various pharmaceutical forms of the same drug? Clearance Bioavailability Bioequivalence * Maximum concentration (Cmax) Time of Maximum Concentration (Tmax) Which of the following drugs is a major inhibitor of enzymes that metabolize other drugs? Barbiturates Ethanol Rifampicin Cimetidine *

Which is a route of elimination of ethanol easily exploited for estimating the amount of ethanol in the blood? Kidney- (Urine analysis) Hepatic route- (Bile analysis) Pulmonary route- (Breath analysis) * Skin- (Sweat analysis) Saliva- (Saliva analysis) Which of the following is a quantitative measure of the efficacy of a drug? Maximum concentration (Cmax) Maximum response (Emax) * Drug concentration at 50% maximum effect (ED50) Dissociation constant (Kd) Maximum binding of receptors (Bmax) 5. What of the following represents the quantitative measure of the safety of a drug? [a] Lethal dose [b] Effective dose [c] Therapeutic index * [d] Therapeutic window [e] Potency 6. Drug A is known to exhibits first order elimination kinetics. If 540mg is given intravenously, 270mg is eliminated during the first 45minutes. If 440mg is given intravenously, how much of the drug will remain after 90minutes? [a] 22.5mg [b] 55mg [c] 110mg * [d] 170mg [e] 220mg 7. Drug B is known to exhibit zero order elimination kinetics. If 100mg is administered intravenously, 50mg is eliminated after 75minutes. Following administration of 200mg, how much time will be required for 100mg to be eliminated? [a] 37.5minutes

[b] 75minutes * [c] 150minutes [d] 225minutes [e] 300minutes

Section B: OPEN Questions -

8. Cite the various components of the interaction between a drug and an organism
during the following phases:

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(i) the pharmaceutical phase (1pts)--->administration(+/-), disintegration and dissolution (ii) the pharmacokinetic phase (2pts)--->absorption, distribution, metabolism and
excretion

(iii) the pharmacodynamic phase (1pts)--->protein targets and non-protein ones to

produce effect

9. Give a tabulated comparison between the characteristics of drug action that

depend on interactions with receptors (eg histamine antagonists) and the drug action that does not depend on receptors (eg alcohol). (2pts)SS and give a clinical application of drugs that block these receptors (2pts)

10. Describe the mechanism of signal transduction of cholinergic nicotinic receptors

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