Drug name Omeprazole Doage: 40mg IV OD

General classification Antacids, Antireflux Agents & Antiulcerants

Mechanism of action Omeprazole reduces gastric acid secretion through a unique mechanism of action. Omeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles that do not exhibit anticholinergic or histamine antagonistic properties. It inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphate (H+/K+ ATPase), the proton pump of the gastric parietal cell. This effect is dose related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.

Contraindication Patients with known hypersensitivity to any component of Risek or to substituted benzimidazoles.

Side effect Headache Diarrhea Abdominal pain Nausea Dizziness Asthenia (loss of strength) Vomiting Constipation Back pain Rash Cough

Nursing responsibility Give before meals Do not crush or chew tablets, swallow whole Evaluate for therapeutic response like relief of Gastrointestinal symptoms Question if Gastrointestinal discomfort, nausea, and diarrhea occurs.

Drug name Amoxicillin + Sulbactam

General classification Anti-infective

Mechanism of action Destroys bacteria by inhibiting bacterial cell wall synthesis during microbial multiplication

Contraindication Contraindicated with allergy to cephalosporins or penicillins, or other betalactamase inhibitors

Side effect Lethargy Hallucinations seizures nausea vomiting diarrhea

Nursing responsibility Culture infected area prior to treatment; reculture area if response is not expected Give in oral preparations only; amoxicillin is not affected by food Continue therapy for at least 2 days after signs of infection have disappeared; continuation for 10 full days is recommended Use corticosteroids or antihistamines for skin reactions

Drug name Ketorolac Dosage: 30mg IV q8 NST(-) PRN for pain

General classification Analgesic, Antipyretic, AntiInflammatory

Mechanism of action Interferes with prostaglandin biosynthesis by inhibiting cyclooxygenase pathway of arachnoidic acid metabolism; also acts as potent inhibitor of platelet aggregation

Contraindication Hypersensitivity Concurrent use of aspirin, other NSAIDs, or probenecid Peptic ulcer disease GI bleeding or perforation

Side effect Drowsiness Headache Dizziness Nausea and vomiting

Nursing responsibility Advise pt. to minimize GI upset by eating small, frequent servings of healthy foods Advise pt. to avoid driving and other hazardous activities Tell pt. to immediately report bleeding and adverse CNS reactions Instruct pt. to avoid aspirin and herbs during the therapy