Priscila Badilla Duartes

Identify new breast cancer genes According to an article published this week in the online version of The Guardian, has been identified a new group of common genetic markers of breast cancer, which is the most important development of the last ten years ahead of the understanding of this disease . Scientists have discovered that if any of these four genes is defective can increase the chances of developing breast cancer, these possibilities can increase up to 60% if two genes are defective. This explains why women who have a close relative with breast cancer are twice as likely to develop the disease and offers hope to develop a test to detect these genes in the near future. Scientists hope that these same techniques also help to reveal the origin of other cancers. The research, published online in the journals Nature and Nature Genetics, has conducted an international coalition of researchers led by Cancer Research UK, University of Cambridge. The scientists studied 800 parts of the genome and identified 11,000 people "indicators" (or blocks of DNA that target genes) common in women with breast cancer, who studied more than 8,000 women. In the final process, involving 40,000 women, narrowed the search to five common identifiers in women with cancer than in those without the disease. Indicators guided them to four genes that researchers believe are responsible for the high risk of breast cancer among the patients studied. Now scientists hope to find a fifth gene. It is believed that two of the identified genes, the TNRC9 FGFR2 and increase the risk of breast cancer by about 20% in women carrying a defective copy of one of them and between 40% and 60% in the having two defective copies. In women who have a defect in one of the other two genes increases the risk by 10%. Up to 10% of breast cancers have a genetic component and scientists discovered genes are associated with 25% of them. However, globally the discovered genes equivalent to only 4%, ie only about 179 of the 44,000 breast cancers diagnosed each year.

Priscila Badilla Duartes

The techniques used are similar to those that helped identify the gene for obesity a month ago. According to the study's author, Douglas Easton, director of the Genetic Epidemiology Unit, Cancer Research UK, Cambridge: "This opens up new lines of investigation."

Paraphrase The main idea of the paragraph I. The new group of genetic markers of breast cancer The main idea of the paragraph II. The odds of a 60% exists if both genes are defective, that indicates a likelihood of breast cancer. The main idea of the paragraph III. Investigated 800 women to detect more indicators which resulted in four indicators but do not rule out the five indicator. The main idea of the paragraph IV. It is believed that two of the genes identified by 20% would increase female carriers, 40% and 60% two defective copies and 10% in two defective genes, that in breast cancer. The main idea of the paragraph V. Up to 10% of the genes have a high risk of breast cancer. The main idea of the paragraph VI.

Priscila Badilla Duartes

According to Douglas Easton techniques used are the same q was made a month in the obesity gene. Connate Genes Cancer Final Version Director

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