LxAMLn CLnL8AL uL C8lnA

LS un LxAMLn A8ACLlnlCC A8A CCnll8MA8 C 8LCPAZA8 CSl8LLS ulACnCS1lCCS uL A1CLCClAS

8LSLn1A 18LS A81LS llSlCC CulMlCC ? MlC8CSCClCC
LA 8LCCLLC1A uL C8lnA uL8L PACL8SL uL lC8MA AuLCuAuA SlCulLnuC ALCunCS ASCS
a) uL8L SL8 LA 8lML8A C8lnA uL LA MARAnA ?A CuL LS LA MAS 8L8LSLn1A1lvA C8AClAS A LAS PC8AS uL
A?unC ? 8LCSC 8LvlAS
b) 8LALlZA8 un ASLC uL LCS CLnl1ALLS 8LvlC A LA 8LCCLLC1A A8A Lvl1A8 CCn1AMlnAClCn uL LA MuLS18A
CCn C18AS SLC8LClCnLS
c) LL 8lML8 LlCuluC u8lnA8lC uL8L SL8 uLSCA81AuC ?A CuL LS1L SCLC Sl8vL A8A LlMlA8 LA vlA u8lnA8lA
uL ALCunA 8CLllL8AClCn 8AC1L8lAnA CuL uulL8A LxlS1l8
d) LL LlCuluC uLL MLulC LS LL CuL SL8vl8A A8A LA MuLS18A ?A CuL vlLnL uL LA C8ClCn uL MA?C8
CAACluAu uL LA vL!lCA ? Sl8vL A8A LvALuA8 ML!C8 LAS CA8AC1L8lS1lCAS uL LA C8lnA
e) LL uL1lMC LlCuluC 1AM8lLn uL8L SL8 uLSCA81AuC ?A CuL 8CvlLnL uL LA A81L CS1L8lC8 uL LA vL!lCA
uCnuL uLuL PA8L8 uLCSl1C uL SLulMLn1CS CuL AL1L8Ln LCS 8LSuL1AuCS
f) LA MuLS18A uL8L MAn1LnL8SL 8Ll8lCL8AuA A unA 1LML8A1u8A C8 uL8A!C uL LA 1LML8A1u8A
AM8lLn1L
g) Ln 8LLAClCn CCn LCS 8L8LS C8 Su lnCAACluAu uL CCMunlCA8SL ? uL CCn18CLA8 LSlln1L8LS LxlS1Ln
CCLLC1C8LS uL C8lnAS LSLClALLS CuL CCnSlS1L Ln unA 8CLSA LAS1lCA CuL Ln Su A81L SuL8lC8 1lLnL
un C8lllClC CCn AuPLSlvC
h) LA MuLS18A Ln Mu!L8LS nC uLuL SL8 1CMAuA uu8An1L LA MLnS18uAClCn

1 LxAMLn llSlCC

O CCLC8 uL LA C8lnA AMA8lLLC

LS1L uLuL 8LSLn1A8 vA8lAClCnLS llSlCLCClCAS uAuAS C8 LL LS1AuC uL Plu8A1AClCn uLL lnulvluuC ? C8 LL
vCLuMLn ? CCMCSlClCn uLL LlCuluC Lx18ACLLuLA8

L8C 1AM8lLn LxlS1Ln vA8lAClCnLS A1CLCClCAS LL CCLC8 uL LA C8lnA uLuL CAM8lA8 C8 LA lnCLS1A uL
ClL81CS MLulCAMLn1CS (vl1AMlnA 8 8llAn1lClnA*) CuL AL LxC8L1A8SL 1lRLn LA C8lnA ? uu8An1L LL Cu8SC uL
ALCunAS LnlL8MLuAuLS

AuMLn1C uL LA 8lLl88u8lnA Ln SAnC8L (CCLC8 MA88Cn CSCu8C) uLnCMlnAuA CCLu8lA

CuAnuC PA? SAnC8L Ln LA C8lnA (Sl LS A8unuAn1L SL8A CCLC8 8C!C Sl LS LSCASC SL8A CSCu8A)
uLnCMlnAuA PLMA1u8lA LA PLMA1u8lA uLuL SL8 MlC8CSCClCA Ln LCS CASCS uL CLCML8uLCnLl8l1lS C
MAC8CSCClCA 8CuuC1C uLL SAnC8AuC uLL Ll1LLlC uL LA vlA u8lnA8lA ?A SLA C8 CALCuLCS uLSLnulLnuC C
C8 Ll1lASlS vLSlCAL 1AM8lLn uLu SL8 C8 ClS1l1lS u8L18l1lS CA8ClnCMAS uL vL!lCA C uL 8CS1A1A C
18AuMA1lSMCS 8LnALLS ? uL LA vlA u8lnA8lA

uu8An1L 8CCLSCS lnlLCClCSCS u8lnA8lCS C8 L!LMLC CuAnuC PA? uS Ln LA C8lnA SL uLnCMlnA lu8lA
(LA C8lnA LS 8LAnCA)

*An1l8lC1lCC Ln LL 18A1AMlLn1C uL LA 1u8L8CuLCSlS CuL 1lLnL LA CA8AC1L8lS1lCA uL 1LRl8 uL AnA8An!AuC
1CuAS LAS SLC8LClCnLS (C8lnA SALlvA LAC8lMAS L1C)
O ASLC1C uL LA C8lnA 18AnSA8Ln1L C 18AnSLuCluA

SL LvALuA C8 LA CAACluAu CuL 1LnCA LA LuZ uL LnL18A8 LA C8lnA CLnL8ALMLn1L SL PACL A SlMLL vlS1A
CCLCCAnuC un C8!L1C AL C18C LAuC uLL 8LCllLn1L CuL CCn1LnCA LA MuLS18A ? Sl LS1L uLuL SL8
ulS1lnCuluC A LA vlS1A Ln1CnCLS 1Lnu8A un ASLC1C 18AnSA8Ln1L nC8MAL

Ln CCnulClCnLS A1CLCClCAS uLuL SL8 1u88lA C8 C8lS1ALu8ClA LS uLCl8 8LSCLnClA uL C8lS1ALLS Ln LA
C8lnA CCMC A8LnlLLA C C8lS1ALLS uL CxALA1C uL CALClC lCSlA1C C u8A1C ? 1AM8lLn SL 8LSLn1A 1u88lA Ln
CASCS uL lnlLCClCnLS u8lnA8lAS

O CLC8 5ol Ceoetls C CA8AC1L8lS1lCC

uLuL SL8 MCulllCAuC AL LS1A8 LxuLS1C AL MLulC AM8lLn1L C CuAnuC SL lnClL8L ALCun MLulCAMLn1C
(vl1AMlnA 8 An1l8lC1lCCS) Ln 8CCLSCS lnlLCClCSCS

2 LxAMLn CulMlCC

O CSMCLA8luAu 300 800 mCsm/L

uLLnuL uL LA CCnCLn18AClCn* uL LCS SCLu1CS ulSuLL1CS Ln LA C8lnA un AuMLn1C uL LS1A CSMCLA8luAu
uLuL SL8 A1CLCClCC un L!LMLC uL LLLC LS An1L LA uLSPlu8A1AClCn

LA CSMCLA8luAu LS ulllClL LvALuA8LA Ln LA 8AC1lCA CLlnlCA ?A CuL LS1A uL8L SL8 MLuluA C8 un
CSMCML18C

*CAn1luAu uL SCLu1CS ulSuLL1CS Ln LA C8lnA

O uLnSluAu 1003 1013

uLLnuL uLL LSC MCLLCuLA8** uL LCS SCLu1CS ulSuLL1CS Ln LA C8lnA C8 L!LMLC LCS vALC8LS nC8MALLS
uL uLnSluAu SL vL8An MCulllCAuCS C8 LA 8LSCLnClA uL 8C1LlnAS CCMC LA AL8uMlnA CuL 1lLnLn AL1C
LSC MCLLCuLA8

LL CAM8lC uL uLnSluAu nCS A?uuA A SA8L8 Sl LL AClLn1L LS1A LxC8L1AnuC MuCPC C CCC LlCuluC C8 LA
C8lnA C8 L!LMLC LCS AClLn1LS uLSPlu8A1AuCS 1Lnu8An unA uLnSluAu C8 LnClMA uL LCS vALC8LS
nC8MALLS ? LA C8lnA Mu? ulLuluA 1Lnu8A unA uLnSluAu lnlL8lC8 A ulCPCS vALC8LS

uLuL MLul8SL MLulAn1L un LSLC1CML18C uL LuZ C C8 unA Cln1A 8LAC1lvA Cu?CS 8LSuL1AuCS SL8An
CuALl1A1lvCS Lx8LSAnuCSL Ln C8uCLS

**1AMARC uL LCS SCLu1CS uLlSuLL1CS Ln LA C8lnA

O P 43 8

CLnL8ALMLn1L LA C8lnA LS ACluA LL P uLLnuL uL LCS ALlMLn1CS CuL CCnSuMlMCS An1L 8CCLSCS
lnlLCClCSCS LL P SL8 MAS ALCALlnC (83 9) ALCunCS lA8MACCS 1AM8lLn LC MCulllCAn C8 L!LMLC LA
ASl8lnA

O CLuCCSA nLCA1lvC

1LM8lLn uLuL SL8 (+) LSCASC (+++) A8unuAn1L
(++) MCuL8AuC (++++) Mu? A8unuAn1L
Ln CCnulClCnLS llSlCLCClCAS nC uL8L PA8L8 CLuCCSA Ln C8lnA ?A CuL A8SCLu1AMLn1L 1CuA LA CLuCCSA
CuL SL llL18A Ln LL CLCML8uLC SL 8LA8SC88L Ln LL 1u8uLC 8CxlMAL SlLM8L ? CuAnuC LCS nlvLLLS uL
CLuCCSA Ln SAnC8L SLAn nC8MALLS (70110 mg/dL ? PAS1A 140 mg/dL 2 PC8AS uLSuLS uL unA CCMluA) Sl LCS
nlvLLLS uL CLuCCSA Ln SAnC8L LS1An C8 LnClMA uLL uM88AL LASMA1lCC 8LnAL CuL LS LL MAxlMC nlvLL A
A81l8 uLL CuAL PA88A C8lnA Ln SAnC8L (180200mg/ul)

O 8C1LlnAS nLCA1lvC 130 mg/24h

LL 93 uL LAS 8C1LlnAS CuL LCC8An A18AvLSA8 LA MLM88AnA uL llL18AClCn C8 CSLL8 8A!C LSC
MCLLCuLA8 ? CCn MLnC8 CA8CA LLLC18lCA nLCA1lvA SCn 8LA8SC88luAS LL 8LS1An1L LS LxC8L1AuC C8 LA
C8lnA SlLnuC LL vALC8 nC8MAL 130 mg/24h Ln1CnCLS AA8LCL8A CCMC nLCA1lvC Ln LA Cln1A 8LAC1lvA

LxlS1Ln Cln1AS LSLClALLS A8A uL1LC1A8 MlC8CAL8uMlnu8lA CuL nCS uL1LC1A Mu? LCuLRAS CAn1luAuLS
uL 8C1LlnAS Ln LA C8lnA ? LC nC8MAL LS CuL SLA uL 30 mg/24h LS1C nCS L8Ml1L uL1LC1A8 8C1Llnu8lAS
C8 nLl8CA1lAS 8LCCSLS 8lLn SLAn C8 ulA8L1LS PlL81LnSlCn LnlL8MLuAuLS CLCML8uLA8LS L1C

LAS 8C1LlnAS Ln C8lnA AuMLn1An Ln CCnulClCnLS llSlCLCClCAS uu8An1L LL L!L8ClClC llSlCC Sl LA MuLS18A
SL 1CMA lnMLulA1AMLn1L AL llnALlZA8 LA AC1lvluAu llSlCA ? SL uLnCMlnA8A 8C1Llnu8lA 18AnSl1C8lA
A1CLCClCAMLn1L PA88A 8C1Llnu8lA Ln LCS LS1AuCS PlL8ulnAMlCCS CCMC LA llL88L AunCuL 1AM8lLn
SL8A 18AnSl1C8lA uL SL8 unA 8C1Llnu8lA L8SlS1Ln1L lnulCA8lA unA CSl8LL LnlL8MLuAu CLCML8uLA8

uL8L CuAn1lllCA8SL LCS nlvLLLS uL 8C1LlnAS Ln C8lnA A 18AvLS uL un LxAMLn LLAMAuC 8C1Llnu8lA uL 24
PC8AS uCnuL SL uL8L 8LCCLLC1A8 LA C8lnA uL 24 PC8AS CCMC SL PACL A8A LA uLu8AClCn LA 8C1Llnu8lA
uLuL SL8 uL C8lCLn 1u8uLA8 (C8 LA nC A8SC8ClCn uL LAS MlSMAS C 18AS1C8nCS Ln LCS MLCAnlSMCS uL
18AnSC81L) C 1LnL8 C8lCLn Ln LA MLM88AnA uL llL18AClCn (C8 CLCML8uLCA1lA) C Ln LA 8CuuCClCn uL
8C1LlnAS AnC8MALLS

LuLCC uL uL1L8MlnA8 LL nuML8C uL 8C1LlnAS 8LSLn1LS Ln LA MuLS18A ? LL 1lC uL LLLAS (uLuL SL8
8C1Llnu8lA SLLLC1lvA C nC SLLLC1lvA) AuLMAS uL LAS 8C1LlnAS 8LSLn1LS Ln SAnC8L LA uLu8AClCn uL LA
C8LA1lnlnA LA C8LA1lnlnA CCn1LnluA Ln SAnC8L CASLS A81L8lALLS SL Cu8A LLLCA8 A un ML!C8
ulACnCS1lCC ? uL nC SL8 ASl uL8L8A SL8 8LlL8luC A un LSLClALlS1A

Ln1CnCLS LxlS1Ln 8C1Llnu8lAS 18AnSl1C8lAS C L8SlS1Ln1LS C8 LnlL8MLuAu CLCML8uLA8 (8C1Llnu8lA
CLCML8uLA8) 1u8uLA8 (8C1Llnu8lA 1u8uLA8) C C8 LxCLSC uL 8CuuCClCn uL 8C1LlnAS Ln SAnC8L
(MlLLCMA MuL1lLL SC88L8CuuCClCn uL lgs AnC8MALLS)

O CL1CnAS nLCA1lvC

LCS CuL8CS CL1CnlCCS SCn 8CuuC1CS uLL ML1A8CLlSMC uL LCS ACluCS C8ASCS CCMC LL
8L1APlu8Cxl8u1l8A1C ACL1CACL1A1C ? ACL1CnA llSlCLCClCAMLn1L uL8L LS1A8 nLCA1lvC Ln LA C8lnA L8C
LA SC88Lu1lLlZAClCn uL LCS CuL8CS CL1CnlCCS uLuL 8CuuCl8 unA CL1CACluCSlS (C8 ulA8L1LS
ALCCPCLlSMC A?unC 8CLCnCAuC 24 h AnC8LA1l1lS L1C)



O 8lLl88u8lnA nLCA1lvC

Ln LA C8lnA SCLC SL LnCuLn18A LA u8C8lLlnA (ML1A8CLl1C uL LA 8lLl88u8lnA) CuL LS LL lCMLn1C uLL CCLC8
CA8AC1L8lS1lCC uL LA C8lnA

O Pb nLCA1lvC

SCLC Ln CASCS uL PLMA1u8lA (SAnC8L Ln C8lnA) SL Cu8A A8LClA8 Pb Ln C8lnA

O nl18l1CS nLCA1lvC

SCn 8CuuC1CS uLL ML1A8CLlSMC uLL nl18CCLnC ? LAS CSl8lLluAuLS uL CuL LS1Ln 8LSLn1LS SL8A uu8An1L
8CCLSCS lnlLCClCSCS u8lnA8lCS ?A CuL ALCunAS 8AC1L8lAS 1lLnLn un ML1A8CLlSMC nl18CCLnAuC Mu?
ACLLL8AuC SC88L 1CuC Ln lnlLCClCnLS u8lnA8lAS AL1AS (lLLCnLl8l1lS)

3 LxAMLn MlC8CSCClCC C SLulMLn1C u8lnA8lC

SL 1CMA un CCC uL MuLS18A uL C8lnA SL LLLvA A un 1u8C uL LnSA?C ? SL CLn18lluCA C8 unCS Mlnu1CS A8A
SLA8A8 LCS LLLMLn1CS SCLluCS uL LA C8lnA unA vLZ PLCPC LS1C SL 1CMA LL SLulMLn1C CCn unA MlC8ClL1A
? LS LLLvAuC A AnALlSlS MlC8CSCClCC ? SL 8LC81A8An LL nuML8C uL CLLuLASC8 CAMC uLL MlC8CSCClC

O PLMA1lLS 33 C

Sl LA CAn1luAu LS MA?C8 LS1AMCS Ln 8LSLnClA uL unA PLMA1u8lA MlC8CSCClCA

O LLuCCCl1CS 03 C

SL uLnCMlnA LLuCCCl1u8lA Sl PA? unA CAn1luAu MA?C8 uL CLC8uLCS 8LAnCCS Ln LA C8lnA CLnL8ALMLn1L
8CvCCAuA C8 lnlLCClCn u8lnA8lA

O CLLuLAS Ll1LLlALLS 03 C

SCn 8CvLnlLn1LS uL LA uLSCAMAClCn uLL Ll1LLlC uL LAS vlAS u8lnA8lAS

O ClLlnu8CS 03 C

SCn LS18uC1u8AS ClLlnu8lCAS CCnS1l1uluAS C8 un LSCuLLL1C 8L8LSLn1AuC C8 LA CLuCC8C1LlnA uL
1AMMPC8SlALL CuL LS 8CuuCluA C8 LAS CLLuLAS uLL Ll1LLlC uLL ASA uL PLnLL

LS Mu? lMC81An1L uL1L8MlnA8 LL 1lC uL ClLlnu8CS 8LSLn1LS ?A CuL LS1CS uLuLn SL8 uL vA8lCS 1lCS uL
ACuL8uC A LA LS18uC1u8A CuL LC CCuL ASl 1LnLMCS

*ClLlnu8CS PLMA1lCCS C L8l18CCl1A8lCS CuL LS1An CCuAuCS C8 CLC8uLCS 8C!CS LS A1CLCClCC ?A
CuL uLMuLS18A PLMA1u8lA 8LnAL C8 CLCML8uLCnLl8l1lS

ClLlnu8CS LLuCCCl1A8lCS CCuAuCS C8 CLC8uLCS 8LAnCCS nCS ulCL CuL PA? lnlLCClCn u8lnA8lA AL1A
CLnL8ALMLn1L SL C8SL8vAn Ln LAS lLLCnLl8l1lS LS 18A1A8LL ? 8LvL8Sl8LL

*ClLlnu8CS AnCPCS LS1An 8LSLn1L Ln LnlL8MLuAuLS 8LnALLS C8 L!LMLC LnlL8MLuAuLS 1u8uLA8LS
1u8uLCln1L8S1lClALLS uLL 8lRCn ? Ln LA lnSullClLnClA 8LnAL C8CnlCA

O C8lS1ALLS LSCASCS

SCn C8lS1ALLS LLlMlnAuCS C8 LA C8lnA CuL uLuLn SL8 uL CxALA1C u8A1C ? lCSlA1C SCn LSCASCS Ln
CCnulClCnLS nC8MALLS L8C 1AM8lLn uLuLn SL8 MCuL8AuCS C A8unuAn1LS lnulCA unA CSl8LL
A1CLCClA ? SL8A nLCLSA8lC unA LCCC8AllA A8uCMlnAL CCn LnlASlS 8LnAL A8A uLSCA81A8 LA 8LSLnClA uL
CALCuLCS 8LnALLS

O 8AC1L8lAS LSCASAS

Ln CCnulClCnLS nC8MALLS SCn LSCASAS Sl SCn MCuL8AuAS C A8unuAn1LS lnulCAn unA lnlLCClCn u8lnA8lA C
CuL LA MuLS18A LS1L CCn1AMlnAuA uL8L ln1LC8ASL !un1C CCn LCS LLuCCCl1CS L lnCLuSC CCn LCS
L8l18CCl1CS

1AM8lLn LxlS1L un SLulMLn1C Mlnu1AuC CuL SCLC SL SCLlCl1A Ln ALCunCS LA8C8A1C8lCS LSLClALlZAuCS ? LS
LSLClllCC A8A LvALuA8 LAS PLMA1u8lAS LL AClLn1L uL8L vAClA8 Su vL!lCA C8 CCMLL1C 8LCSA8 C8 2
PC8AS ? LuLCC 1CMA8 unA MuLS18A uL C8lnA LS1A MuLS18A SL vA A CLn18lluCA8 ? LuLCC SL8A LvALuAuA Ln
un MlC8CSCClC uL CAMC CSCu8C SA8lLnuC CuL LS unA 8uL8A uL C8lnA uL 120 Mlnu1CS SL uL8L
uL1L8MlnA8 CuAn1ASCLLuLAS C8 Mlnu1C LxC8L1A LL AClLn1L