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Hiv and Aids

Hiv and Aids

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Published by: maponloo on Jun 08, 2011
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05/21/2012

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HIV AND AIDS

WORLD VIEW 33 million persons infected in 2007
AIDS HAS CLAIMED JUST UNDER 25 MILLION LIVES SINCE IT WAS DISCOVERED 20 YEARS AGO.
East Asia & Pacific 700,000 - 1.3 million South & South–East Asia 4.6 – 8.2 million

SINCE HIV/AIDS WAS DISC0VERED 60 MILLION PEOPLE (THE POPULATION OF UK) HAVE BEEN INFECTED

North America 790,000 – 1.2 million

Western Europe 520,000 – 680,000

Eastern Europe & Central Asia 1.2 – 1.8 Million

North Africa & Middle East Caribbean 350,000 – 590,000 470,000 – 730,000 Latin America 1.3 – 1.9 million

Sub-Saharan Africa 25.0 – 28.2 million

Australia & New Zealand 12,000 – 18,000

2.7 MILLION PEOPLE WITH AIDS ARE CHILDREN UNDER 15.

HALF OF NEW INFECTIONS OCCUR IN 1524 YEAR OLDS

17.6 MILLION PEOPLE WITH AIDS ARE WOMEN.

STRUCTURE OF THE VIRUS

HIV AND HUMAN BODY

HIV AND HUMAN BODY

Progression of the disease
Sero-conversion in 33 days
A
800-1200 CD4+ T-cell count Viral load

200

B
Days

C
Years

VCT Results for 2004-2006, Mae Tao Clinic
1200 1055 1000

800

740 644

600

400 197 200 110 14.86 0 2004 2005 2006 Positive HIV % positive 128 19.87 18.67

Total VCT tests

HIV/AIDS
HIV AIDS AIDS

HIV

ART

ART

Services
VCT PMCT

PEP

HIV/AIDS

HIV/AIDS

HIV
H I Human Immuno-deficiency Immune Deficiency : : :

?

V

Virus: (HIV

!

The Immune System T Cells (CD4 Cells) = Immune system
CD4

CD4 800-1500/ml

CD4

Disease

Disease

HIV and the Immune System
HIV CD4 CD4

HIV

CD4 HIV HIV

HIV HIV

CD4

HIV

Enters CD4 Cells
HIV CD4 CD4 CD4

HIV

Kills CD4 Cells

CD4 HIV CD4 CD4 HIV

800-1500/ml

CD4 AIDS

HOW HIV ATTACK OUR HEALTH

HOW BODY DEFEAT DISEASES

HIV and the CD4 Count
¨¨ HIV
CD4
Amount in Body

CD4

HIV

CD4

HIV
?
1500 to 800 CD4 CD4 COUNT

AIDS

Below 500 CD4 - Opportunistic Infections

200 CD4
CD4 AIDS

AIDS

!

HIV

AIDS
?

• Developed World:
ART HIV

• Developing World:

AIDS
A I D Acquired: Immune: Deficiency:

?

S

Syndrome: AIDS

Opportunistic Infections(OIs) ?
HIV CD4
¨

opportunistic infections

HIV

opportunistic infections

AIDS
opportunistic infections (OIs)
• • • • • • • • Extensive skin lesion Oral thrush Chronic unexplained fever Chronic diarrhoea TB, dissiminated TB PCP pneumonia Wasting Syndrome Meningitis

• CMV: • Cancer and other many other infections and disorders

Clinical Staging of HIV/AIDS
• Stage I; Asymptomatic • Stage II; Herpes zoster • Stage III &IV; Features of AIDS

HIV

?

?
HIV

?

H

MTCT

Trend of HIV prevalence in ANC pregnant women at MTC from 1999 to 2005
2.50% 2.3% 2.00% 1.50% 1.2% 1.00% 0.8% 0.8% 0.50% 0.00% 1999 2000 2001 2002 2003 2004 2005 2006 1.5% 1.4% 1.5% 1.6%

!
HIV HIV HIV HIV

HIV

HIV HIV HIV

HIV
HIV HIV

HIV

?
HIV ¨

HIV

¨

!
Some Statistics HIV -UK

?

HIV

?
HIV

HIV
HIV (ART)

HIV

Programme

UK

HIV

Whom of them are high risk people?
• Sex worker • Sexually promiscuous man
• House wife • Highway driver • Old lady

• Sex worker • Sexually promiscuous man • House wife • Highway driver

• Old lady

Anti Retroviral (ARV’s) Drugs ?
¨
HIV CD4 Cells HIV HIV HIV

NRTI AZT 3TC D4T ABC

NNRTI NVP FEV

PI Lopinavir Ritonavir Saquinavir

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