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03/04/2011 Causes of metabolic acidosis

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Major causes of metabolic acidosis according to mechanism and anion gap

Mechanism of acidosis Increased AG Normal AG


Increased acid production Lactic acidosis

Ketoacidosis

Diabetes mellitus

Starvation

Alcohol-associated

Ingestions

Methanol

Ethylene glycol

Aspirin

Toluene (if early) Toluene ingestion (if late due to urinary


excretion of hippurate)

Pyroglutamic acid (5-


oxoproline)

Loss of bicarbonate or Diarrhea or other intestinal losses (eg,


bicarbonate precursors tube drainage)

Type 2 (proximal) renal tubular acidosis


(RTA)

Posttreatment of ketoacidosis

Carbonic anhydrase inhibitors

Ureteral diversion (eg, ileal loop)

Decreased renal acid Chronic kidney Some cases of chronic kidney disease
excretion disease
Type 1 (distal) RTA

Type 4 RTA (hypoaldosteronism)

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