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  • ANTIDEPRESIVE

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    livia_ciora
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    This document summarizes different classes of antidepressant medications based on their mechanisms of action: I) Antidepressants with predominant presynaptic action (unimodal) act on a single neurotransmitter like serotonin. Examples include SSRIs like sertraline and fluoxetine which inhibit serotonin reuptake. II) Antidepressants with pre and postsynaptic action (dual) have noradrenergic and serotonergic effects. Tricyclic antidepressants and tetracyclic antidepressants fall into this category. III) Atypical antidepressants have a non-tricyclic, non-tetracyclic, and non-MAOI structure. They include selective serotonin reuptake amplifiers like

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    ANTIDEPRESIVE CU ACTIUNE PREDOMINANT PRESINAPTICA

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    This document summarizes different classes of antidepressant medications based on their mechanisms of action: I) Antidepressants with predominant presynaptic action (unimodal) act on a single neurotransmitter like serotonin. Examples include SSRIs like sertraline and fluoxetine which inhibit serotonin reuptake. II) Antidepressants with pre and postsynaptic action (dual) have noradrenergic and serotonergic effects. Tricyclic antidepressants and tetracyclic antidepressants fall into this category. III) Atypical antidepressants have a non-tricyclic, non-tetracyclic, and non-MAOI structure. They include selective serotonin reuptake amplifiers like

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    89 vistas3 páginas

    ANTIDEPRESIVE

    Cargado por

    livia_ciora
    This document summarizes different classes of antidepressant medications based on their mechanisms of action: I) Antidepressants with predominant presynaptic action (unimodal) act on a single neurotransmitter like serotonin. Examples include SSRIs like sertraline and fluoxetine which inhibit serotonin reuptake. II) Antidepressants with pre and postsynaptic action (dual) have noradrenergic and serotonergic effects. Tricyclic antidepressants and tetracyclic antidepressants fall into this category. III) Atypical antidepressants have a non-tricyclic, non-tetracyclic, and non-MAOI structure. They include selective serotonin reuptake amplifiers like

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    Marcar por contenido inapropiado
    de 3

    I)

    ANTIDEPRESIVE CU ACTIUNE PREDOMINANT PRESINAPTICA


    (UNIMODALE)
    1.

    ACTIUNE ASUPRA UNUI SINGUR NEUROTRANSMITATOR ( SINGLE TARGET )


    5HT

    Inhibitori selectivi ai recaptarii de serotonina


    Sertralina / asentra
    25-50--- >200mg
    Paroxetina / paxetil
    20-50--->60
    Escitalopram / cipralex 10-20
    Citalopram / linisan
    20-->40
    Fluoxetina/ prozac 20-60--->80mg !!
    Fluvoxamina 25100-->300 Seara

    ISRS

    Inhibitori ai recaptarii de norepinefrina


    Reboxetina 8mg/zi

    IRN

    2.

    NA

    DOPA

    inh S

    inh

    ACTIUNE MULTIPLA ( MULTIPLE TARGET)

    Inhibitori ai recaptarii de serotonina


    norepinefrina
    Venlafaxina / efectin 37,5x2----->375mg/zi
    Duloxetinum / Cymbalta 30-60-->120mg
    Milnacipram / ixel 50-100-->200

    IRSN

    inh

    Inhibitori ai recaptarii de norepinefrina


    dopamina
    Bupropion / welbutrin 100x2-->100x3 max450mg
    in 4 doze

    inh

    inh

    II)
    ANTIDEPRESIVE CU ACTIUNE
    PRE SI POSTSINAPTICA ( DUALE )
    NORADRENERGICA SI SEROTONINERGICA
    Antidepresive triciclice
    Amine tertiare
    Clomipramina / anafranil 25mg seara-->100->250mg
    Amitriptilina 100-->300mg
    Doxepina 25-50mg in 1-3 doze
    Imipramina 50-75-150--->200mg/zi
    Amine secundare
    Desipramina 25-->100-200mg/zi max 300mg
    Nortriptilina 25x3/zi max 150 mg/zi

    TCA

    inh

    inh

    inh

    MAO

    Antidepresive tetraciclice
    Mianserina 30-90mg/zi seara
    Maprotilina 50- 75mg
    III)
    ANTIDEPRESIVE CU STRUCTURA
    CICLICA ATIPICA ( non-triciclice, nontetraciclice, non IMAO )

    Amplificatori selectivi ai recaptarii de


    serotonina
    Tianeptina / coaxil 12,5 mg x3/zi

    ASRS

    Agonisti melatoninergici
    Agomelatina / valdoxan 25-50 mhg seara

    Medicamente amplificatoare
    Trazodone / trittico (75)-150-300--> 600mg
    spitalizati!
    Buspirone 7.5mgx2 ori 5mgx3/zi, max 60 mg/zi

    ampl

    IV)
    ANTIDEPRESIVE
    NORADRENERGICE SI SPECIFIC
    SEROTONINERGICE

    ANaSS

    ampl

    ampl

    Mianserina / mianserin
    Mirtazapina/ remeron 15 mg seara, max 45mg
    Inhibitori de monoamino oxidaza
    Moclobemide
    Phenelzine

    IMAO
    RIMAO

    inh

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