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This review highlights the fundamentals and the most prominent advances in
the field of HPLC instrumentation over the last decades. Fundamental aspects
and practical considerations of column switching, conventional (heart-cut)
and comprehensive two-dimensional LC are presented. Different aspects of
microcolumn- and nanoliquid-chromatography are reviewed. Recent progress
in column technology and the demands and developments in instrumentation
and accessories for miniaturized LC are also discussed. In the field of
miniaturization, particularly in chip-based nano-LC systems, some aspects on
micro-fluidic chip fabrication, using particle-packed HPLC microchips or
polymer-based monoliths, are addressed. An introduction to ultra
performance LC (UPLC) is also presented.
http://link.springer.com/article/10.2478/s11532-011-0161-0