Documentos de Académico
Documentos de Profesional
Documentos de Cultura
Durham, Mary F. "A Genomic Approach to Identify the Genetic Basis of Natural
Variation in Lifespan and Age Specific Fecundity and Their Plastic
Responses to Diet in Drosophila Melanogaster." 2013. Digital file.
In this article, the author mainly discussed the influences that the gene acts on
natural variation in lifespan and reproduction, and how these genes interact with
environmental variables. The researcher used the Drosophila melanogaster Genetic
Reference Panel (DGRP), to complete a genome-wide association (GWA) study on
lifespan, age specific fecundity, lifetime fecundity and the plastic response of
these traits.The result suggests that individual genes influence lifespan and fecundity
in a diet specific manner.
I think this article is useful for me because it contains the methods he used to test
and also the hypothesis being tested is related to my topic. The description on the
methods may help me with my experimental design and how I will conduct it. The
data provided in the article can be helpful to my experiment.
Mackay, Trudy F. C., Stephen Richards, and Eric A. Stone. "The Drosophila
Melanogaster Genetic Reference Panel." Nature 482.7384 (2012): 173-78.
Print.
The article mainly explains the Drosophila melanogaster Genetic Reference Panel
(DGRP) which is a community resource charting the molecular and phenotypic
variation in 168 fully sequenced fruitfly strains derived from a single outbred natural
population. The analyses of DGRP data introduce the genomic landscape of genetic
variation, positive and negative selection, and rapid evolution of the X chromosome.
The results also reveal many low frequency variants in novel loci that are associated
with quantitative traits, and explain a large fraction of the phenotypic variance.
This source is useful for me because its content explain the DGRP which is also
mentioned in the methods used off the experiments in the last source. The explanation
helped me with understanding of the last source.
Roff, Derek A. The Evolution of Life History. N.p.: n.p., 1992. Print.
In this book, the basic theory and methods of life histories are explained. It
includes examinations of genetic and optimization approach, the broad scope of life
history, the concept of fitness, the mathematical tools for prediction, the factor
affecting age and so on. It provides a big picture of the theory of life history and
explains it in details.
The explanation of the life history theory and its approaches are very thorough in
this book. The understanding of this theory will help me with the research on the
genetic basis of natural variation of the drosophila.
interests to easily view and analyse acknowledged D. melanogaster gene sets and
compare them with those of other species.
I think this source is helpful for me because I will be using the FlyBase for
searching the genetic sequence, the function of the protein, or the chemical formula of
the gene. This article helps me with how to use the website and where to find the
information I want in the database.
Berman, Gordon J., et al. "Mapping the Stereotyped Behaviour of Freely Moving
Fruit Flies." Interface (2014): n. pag. Print.
In this article, the researchers introduce a method for mapping an animal's actions,
relying only upon the underlying structure of postural movement data to organize and
classify behaviours.They applied this method to the ground-based behaviour of the
fruit fly, Drosophila melanogaster, where they found that flies perform stereotyped
actions roughly 50% of the time, discovering over 100 distinguishable, stereotyped
behavioural states. These include multiple modes of locomotion and grooming. they
used the resulting measurements as the basis for identifying subtle sex-specific
behavioural differences and revealing the low-dimensional nature of animal motions.
This article is helpful for me because it tested the behavior of the drosophila
melanogaster. I can understand the behaviors of the fruit flies with the data provided
in this article.
Reeve, Eric C. R., and Isobel Black. Encyclopedia of Genetics. N.p.: Taylor &
Francis, 2001. Print.
The Encyclopedia includes 125 entries, beginning with the origins of genetics,
and progressing to the structure of DNA and modern theories such as selfish genes.
All branches of genetics are covered, including the genetics of bacteria, viruses,
insects, animals and plants, as well as humans. Important topical issues such as the
human genome project are fully surveyed. There is also a section on techniques and
biotechnology includes modern methods of analysis.
This book is helpful for me because I can get a big picture of what is discussed in
the genetic study. Genetic information of the Drosophila Melanogaster is also
discussed in detail in the book.The section where several methods of analysis is
explained may help me with how I will design my experiment.
mutations therefore occur in non-coding DNA, and these may make an important
contribution to a wide variety of evolutionary processes.
This article is useful for me because it studied the non-coding DNA in drosophila.
It is more likely to cause a mutation occur in non-coding since there are more of the
non-coding ones than the coding ones. The mutation can be a factor of a different
lifespan from other drosophila, and this is related to my research topic.
Cingolani, Pablo, et al. "A Program for Annotating and Predicting the Effects of
Single Nucleotide Polymorphisms, SnpEff." Fly 10.4161 (2012): 80-92. Print.
Pandey, Udai Bhan, and Charles D. Nichols. "Human Disease Models in Drosophila
Melanogaster and the Role of the Fly in Therapeutic Drug Discovery."
Pharmacological Reviews 63.2 (2011): 411-36. Print.
In the article, the author mainly discussed the common fruit fly, Drosophila
melanogaster as a well studied and highly tractable genetic model organism for
understanding molecular mechanisms of human diseases. Many basic biological,
physiological, and neurological properties are conserved between mammals and D.
melanogaster, and nearly 75% of human disease-causing genes are believed to have a
functional homolog in the fly. They review the basic biology of the fly and discuss
models of human diseases and opportunities for therapeutic discovery for central
nervous system disorders, inflammatory disorders, cardiovascular disease, cancer, and
diabetes. They also provide information and resources for those interested in pursuing