Documentos de Académico
Documentos de Profesional
Documentos de Cultura
OBJECTIVES
STRUCTURE OF ALKALOIDS
CHARACTERISTICS:
Alkaloids
form
double
salts
with
as
precipitate
microcrystallographic.
which
are
properties
owing
to
the
such
as
ergotamine.
The
secondary
amine
(R2NH),
PROPERTIES OF ALKALOIDS
and
the
presence
and
the
angiosperms,
the
are
plants.
Solanaceae,
outstanding
and
Berberidaceae
alkaloid-yielding
do
not
generally
(physostigma,
areca),
Reserve
substance
capable
of
BIOSYNTHESIS OF ALKALOIDS
The
biosynthesis
of
many
alkaloidal
as
alkaloidal
precursors
are:
decarboxylation
the
Dragendorffs test
used:
Dragendorffs
reagent
used:
Hager's
reagent
From the
generic name
or the
genus
of the plant
The
specific name
or
species
Common name
ergotamine)
From
their
physiologic
activity
(e.g
emetine, morphine)
CLASSIFICATION OF ALKALOIDS
Upon
reduction,
pyridine,
is
the
tertiary
converted
into
base,
the
3 Subgroups
Derivatives
of piperidine
Derivatives
of nicotinic acid
Derivatives
pyrrolidine
Areca
Arecoline
Hydrobromide
Lobelia
Lobeline
Nicotine
NICOTINE
A primarily product of
root metabolism, but
the formation of small
amounts, as well as
subsequent reactions
such as demethylation
of nicotine, can occur
in leaves of plants.
tabacum
Linn
(Fam.
Solanaceae)
Nicot
Europe
who
introduced
tobacco
in
USES:
ARECA
Areca- a Spanish
and Portuguese
term for betel nut
Catechu-
East
Indian
name
for
an
Uses:
Pharmaceutic purposes
Taenifuge
Constituents:
pyridine derivatives.
LOBELIA
Indian tobacco
Lobelia named in
honour of a Flemish
botanist Matthias de L
Obel
Uses:
Anti-smoking preparations
Lobeline
sulfate
incorporated in tablets or
Lobeline
asthma
Chronic bronchitis
Constituents:
TROPANE ALKALOIDS
Belladonna leaf
Hyoscyamus
Stramonium
Atropine
Hyoscyamine
Scopolamine
Coca
Cocaine
BELLADONNA
Belladonna leaf,
Belladonna herb or deadly
nightshade leaf
Linn or
Belladonna
from
Italian
word
accounts
for
its
use
as
Constituents:
(-)- hyoscyamine
remainder atropine
Apoatropine
Belladonnine
Cuscohygrine
Scopolamine
SOLANACEOUS ALKALOIDS
(-) hyoscyamine
prepared
synthetically
but
are
usually
Atropa belladonna
Datura stramonium
Hyoscyamus niger
Dubosia plants
Atropine
It is a CNS stimulant.
Scopolamine
It
is
employed
for
preanesthetic
Hyoscyamine
Hyoscyamine sulfate
extremely poisonous
sialorrhea
and
Atropine sulfate
It is extremely poisonous.
Scopolamine or hyoscine
LEVOROTATORY
It is classified as anticholinergic.
Hyoscyamus
flowering
Hyoscyamus
or
fruiting
niger
crop
of
Linn
(Fam.
than
0.04%
Solanaceae)
It
contains
not
less
alkaloids of hyoscyamus.
Hyoscyamus
The
alkaloids,
scopolamine,
hyoscyamine
0.05%
to
0.15%
and
of
HYOSCYAMUS
STRAMONIUM
Stramonium
STRAMONIUM SEED
from D. stramonium
COCAINE
Dried leaves of
Erythroxylum coca
Lamarck which is
commercially known as
Huanuco coca or of E.
truxillense Rusby
Truxillo coca (Fam.
Erythroxylaceae)
in Peru)
Contains three basic types of alkaloids:
Derivatives of ecgonine
Derivatives of tropine
Derivatives of hygrine
Huanuco coca
Truxillo coca
Cocaine hydrochloride
Colorless
crystals
or
as
white,
crystalline powder.
CNS stimulant
Crack
QUINOLINE ALKALOIDS
including
those
obtained
from
cinchona
group
that
are
therapeutically
important
at
and
its
methoxycinchonine.
isomer,
quinidine,
represent
6-
CINCHONA BARK
Calisaya (a tree)
Ledgeriana
Charles Ledger)
named
in
honor
of
CUPREA BARK
it
contains
numerous
transversely
CINCHONA ALKALOIDS
Quinidine
Use
to
treat
various
cardiac
toxic
reaction
occurs
at
levels
above
8mcg/ml.
Quinidine sulfate
Quinidine gluconate
Quinidine polygalacturonate
In
addition
it
produces
incidence of GI irritation
lower
Quinine
Diastereoisomer of quinidine
Quinine Sulfate
Uses
Antimalarial
It
is
widely
used
for
the
prevention
and