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Doc Code: PET.SPRE.ACK Pr018829 07-00) 3 Description: Peition for 12m clerated Exam Approved or use tough 071172044 OME GES C058 eee eee reer erasers eecrene nec U.S. Patent and Trademark Office: U. S. DEPARTMENT OF COMMERCE Under tne Paperwork Reduction Ato 1885, operons are required to espond fo a clean of ifrmaonuness dap a vald ONE contol number PETITION TO MAKE SPECIAL UNDER ACCELERATED EXAMINATION PROGRAM ‘Attorney Number Docket First Named 144790,05.2003, eens Feng Zhang Application Number (if Known) Title of Invention CRISPR-CAS SYSTEMS AND METHODS FOR ALTERING EXPRESSION OF GENE PRODUCTS REVISE! ‘APPLICANT HEREBY PETITIONS TO MAKE THE ABOVE-IDENTIFIED APPLICATION SPECIAL UNDER THE D ACCELERATED EXAMINATION PROGRAM. See Instruction sheet on page 3. 7 Clainis of the application: ‘2. The application must contain three (3) or fewer independent ciaims and twenty (20) or fewer total claims. The application may not contain any multiple dependent claims. b. Applicant hereby agrees not to separately argue the patentability of any dependent claim during any ‘appeal in the application. Specifically, the applicant agrees that the dependent claims will be grouped together with and not argued separately rom the independent claim from which they depend in any appeal bref fled in the application (37 CFR 41.37(cK1}(vi). ©. The claims must be directed to a single invention. Taterviews! Applicant hereby agrees to have (if requested by examiner): a. An interview (including an interview before a first Otfice action) to discuss the prior art and any potential {ejections or objections with the intention of clarifying and possibly resolving all issues with respect to patentabilty a that ime, and b. telephonic interview to make an election without traverse ifthe Office determines that the claims are not ‘obviously directed to a single invention, Preexamination Search Statement and Accelerated Examination Support Document: \With this petition, applicant is providing: a preexamination search statement, in compliance with the requirements set forth in item 8 of the instruction sheet, and an “accelerated examination support document” that includes: a. An information disclosure statement in compliance with 37 CFR 1.98 citing each reference deemed most ‘losely related to the subject matter of each of the claims, b. For each reference cited, an identification of all the limitations of the claims that are disclosed by the reference specifying where the limitation is disclosed in the cited reference; ©. A detailed explanation of how each of the claims are patentable over the references cited with the particularity required by 37 CFR 1.111(b) and (c) 4d. Aconcise statement of the utility ofthe invention as defined in each of the independent ciaims (unless the ‘application is a design application), 2. An identification of any cited references that may be disqualified as prior art under 35 U.S.C. 103(c) as ‘amended by the CREATE act; and fA showing of where each limitation of the claims finds support under the first paragraph of 35 U.S.C. 1142.in the written description ofthe specification. IT applicable, the showing must also identify. (1) each means- {or step-}plus-function claim element that invokes consideration under 35 U.S.C. 112, 96 and (2) the structure, ‘material, or acts that correspond to any means- (or step-) plus-function claim element that invokes, ‘consideration under 35 U.S.C. 112, 96. I the application claims the benefit of one or mote applications under tite 35, United St ates Code, the showing must also include where each imitation of the claims finds support under the fist paragraph of 35 U.S.C. 112 in each such application in which such support exists. The infomation i reaued fo obtain crtain a bene bythe public which eo Re andy the USPTO fo process an aplication. Confidentay = governed by USC sand Gi Lane Tna om tana te Zhu canoe, hug pti epg nd nc Peano “bggeston forredusng this burden, sho be sent fo fhe hit normation Offer, US. Patent and Trademarc Otee US. Depart ot Commerce, P.O. BOK 1450, lesandia, VA22313-1450, 00 NOT SEND FEES OR COMPLETED FORMS TO THIS ADORESS, you need assistance n completing the form, call 1-800.PTO-9199 and select option 2 Doc Code: PET.SPREACX Prosse29,07-09) 32 Description: Petition for 12.month Accelerated Exam Approved for use hough 079172014, OMS O65-0058 eee eee reer erasers eecrene nec US. Patent and Trademark Ofice: U5. DEPARTHENT OF COMMERCE Under be Paperwor Reduction Ato 1855, no persons are rere to respond i tection firma unless & dips 2 vas OMS contol number PETITION TO MAKE SPECIAL UNDER ACCELERATED EXAMINATION PROGRAM (Continued) ‘Attorney Docket First Named Noe 144790,05.2003, eens Feng Zhang Attachments: a ‘Accelerated Examination Support Document (see item 3 above). : ‘A statement, in compliance with the requirements set forth in tern 8 of the instruction sheet, detaling the preexaminali ‘search which was conducted c Information Disclosure Statement, Other (e.g, @ statement that the claimed subject matter is directed to environmental qualty, energy, or ‘countering terrorism (37 CFR 1.102(c}2)). a/O Fees: The following fees must be filed electronically via EFS or EFS-Web: a. | The basic fling fee, search fee, examination fee, and application size fee if required) under 37 CFR 1.16. b._ | Petition fee under 37 CFR 1.17(h) - unless the petition is fled with a showing under 37 CFR 1.102(c\2) Signature: Click Remove if you wish to remove this signatory Remove Signature Smitha B. Uthaman! Date 2018-10-15 Name Registration (PrintTyped) ‘Smitha B. Uthaman Nieoar 71355 Click Add if you wish to add additional signatory Ada Slgnatires of al te senor or assignees a record Be ente rete the epresentathe(s) ae requred by accordance wh 37 CFR 1.3 and 10.18. Pease 97 GFR 1) forth form of sinatre Doc Code: PET.SPREACX Prorse 07-08) 3¢ Description. Petiion for 12-month Accelerated Exam Approved or use tough 071172044 OME GES C058 ee ee career ‘Accelerated E) U.S. Patent and Trademark Office: U. S. DEPARTMENT OF COMMERCE Under tne Paperwork Reduction Ato 1885, operons are required to espond fo a clean of ifrmaonuness dap a vald ONE contol number Instruction Sheet Petition to Make Special Under the Accelerated Examination ‘A grantable petition must meet the following conditions: 1. The petton to make special under te accelerated examination program must be fled wth the application and accompanied by he fee set foth in 37 CFR 1.17(h) oF a statement thatthe claimed subject malier is directed to environmental ually, energy, oF countering terrorism, 2. The application must be a non-issue ulily or design appicaton fled under 35 U.S.C. 111(a} 3. The application must be fled electronically using te Office electronic fing system (EFS) or EFS-Web. 4. The application must be complete under 37 CFR 7.51 and In conon for examination on fing. For example te apotcation must be fled togelner with the basic fing fee, search fee, examination fee, and application size fee (i applicable), and an oath ar declaration Under 37 CFR 1.63 5, The application must contain three (8) ar fewer independent claims and twenty (20) or fewer total claims, The application may not contain any mulipie dependent claims, The peition must incude a statement tat applicant will agree not to separately argue the patentability of any dependent claim during any appeal inthe appleation. Specticaly, the applicant's agreeing thal the Gependent claims val be grouped togetner with and nol argued Separately from the Independent claim trom which they depend in any ‘appeal brie led inthe application (37 CFR 41 37(oK1Ki) 6. The claims must be decied to single invention. The petition must include a statement that applicant will agree to have @ lelepnone interview to make an election without traverse ina lelephonie bteview ifthe Office determines that all the claims are not rected toa single nveniion. “The pein must include a statement that applicant will agree to have an interview (including an interview before a fist Office action) to ascuss the prior art and any potential rejections or objections wth tne intenton of clanfying and possibly resolving al Issues with respect to patentability at that ime. {the time offing, applicant must provide a statement that a preexamination search was conducted, including an entiation of the field of searen by United States class and subclass and the date of the searen, where applicable, and, for database searches, the search logic or chemical stuctur or sequence used as a query, the name of the fle or fles searched and the database service, and the date ofthe search, {This preexamination search mustinvolve U.S, patents and patent application publications, foreign patent documents, and ronpatent erature, unless the applicant can justiy vai reasonable certainty Inat no references more perinent than those already ‘entiies are likely toe found in he eliminated source and includes sucha justiication wath tis statement ». This preexamination searen must be arectes tothe clarmed invention and encompass al af he features of the incepencent cians, iving the claims the broadest reasonable inferpretaton «The preexaminaton search must also encompass the disclosed features that may be came, n that an amendment othe claims {inciucing any new claim) thatis not encompassed by the preexamnation search wll be treated as non-tesponsive and wil not be entered 6. search report from a foreign patent office vil nol be accepted uniess the search report satisfies the requirements set forth above. Any statement in suppor of a pation to make special must be based on a good faith belie tna the preexamination search was conducted in compliance with hese requirement. See 37 CFR 1.56 and 10.18, ‘9. Atthe time o ling, applicant must provide in support ofthe pettion an accelerated examination support document that includes: a. An information disclosure statement in compliance with 37 CFR 1.98 citing each reference deemed most closely) related to the subject matter of each of the claims For each reference cited, an Identification of al the limitations of the claims that are cisclosed by the reference speciying “wnere the linvaton Is closed in the cited reference: €-A detalled explanation of how each ofthe claims are patentable over the references cited with the patielanty required by 37 (FR 1.111(b) and (c 4. Aconcige statement ofthe utility of the invention as defined in each ofthe independent claims (unless the application is a ‘esign application) €@, Anisentiteation of any tes references that may be dlquaifies as prior art under 35 U.S.C. 103(c}as:am ende d by the CREATE act; and {LA showing of where each limitation of the claims finds support under the first paragraph of 36 U.S.C. 112 n the writen escripton ofthe specication. If applicable, the showing must aso identty: (1) each means- (or step) plus function dain element that invokes consideration under 38 U.S.C. 112, $6; and (2) the stuctue, material, or acts that corespons to ary means- {or step.) plus-funetion claim element tat invokes consideration under 36 U.S.C. 172, 96. Ihe application claims the Benet of ‘ne or more appleaions under te 35, Unied States Code, the showing must also include where each Imation of he cians finds support under the fist paragraph of 35 U.S.C. 112.n each euch appication in which such suppot exits. For more information, see notice "Changes to Practice for Peiitions in Patent Applications lo Make Special and for Accelerated Examination” available on the USPTO web site at htip:/Mww.uspto.goviweb/office s/pacidapplogsheet htm Privacy Act Statement [The Privacy Act of 1974 (PL. 99-579) requires that you be given certain information in conection with your submission of the atached form related to la patent application or palen. According, pursuant tothe requirements ofthe Act, please be advised that (1 the general authority forthe collection lt tis eformation is 39 U.S.C. 20042); (2) fusing of te information soled is veluntay, ard (3) the principal purpose for which the information Is used by the U.S. Patent and Trademark Ofie is to process andor examine your submission related to a patont application or patent. you do nat Iurish the requested informatio, the U.S. Patent and Trademark Cffce may nol be abe lo process andor examine your submission, wich may result in termination of proceedings or abandonment af he application or expiration of he patent [The information provided by you inthis frm vl be subject othe folowing routine uses: 1 ‘The infomation on this form wil be treated confidentially tothe extent alowed under the Freedom of Information Act (5 U.S.C. 862) and the Privacy Act (5 U.S.C, 8528). Record from this system of racords may be disiosed fo the Department of Justice to determine whether the Fr eedom of information Ac requires disclosure ofthese records. ‘A record trom tis syslem of recards may be disclosed, as a routine Use, inthe course of presenting evidence o @ court, magistrate, or _acmirisratve tribunal, ncucing éeclosures fo opposing counsel inthe course of setiement negotiators. ‘A record inthis system of rocords may be disclosed, a8 a routine use, to @ Member of Congress subiting a request involving an Individual, to whom the record pertains, when the individual has requested assistance ftom the Memter with respect tothe subject matte of the recor. ‘A record inthis system of records may be disclosed, a8 a routine use, to @ contractor ofthe Agency having need forthe information in ‘order to perform a contract. Recplens of information shall be requited to comply wih the roquvements of he Prvacy Act of 1974, as ‘amended, pursuant lo § U.S.C. 562a(7). ‘A record related Io an Intemational Application fled under the Patent Cooperation Trealy in his systom of records may be disdosed, 3s routine use, fo the Intemational Bureau ofthe World Inelectual Property Organization, pursuant to the Patent Cooperation Treaty. ‘A record inthis system of records may be disclosed, asa routine use, to another federal agency for purposes of National Securty review] (58.0. 161) and for review pursuant to the Atomic Energy Act (42 U.S.C. 218(¢). ‘recor trom this system of records may be clsclosed, as a routine use, tothe Administrator, General Services, or hs/ner designee, ‘during an inspection of records conducts by GSA as part ofthat agency's responsibity to recommend improvements inrecorés management practices and programs, unde’ autholy of 44 U.S.C. 2908 and 2906, Such diseosure shall be made in accordance with the {SSA reguiattons governing inspection of record fr tis purpose, ane any otner relevant i.e, GSA or Commerce) drecive. Such clsclosure shall rot be used to make determinations about ni dls ‘A record trom tis system of records may be disclosed, as aroutne use, tothe public ater eter publication ofthe application pursuant to 35 US.C. 122(b) or issuance ofa patont pursuart to 35 U.S.C. 151. Further, a record may be discesed, subject tothe ations of 37 (CFR 1.14, a5 a routine use, tothe pubic the record was fled in an application which became abandoned orn which te proceedings were terminated and wich application is referenced by either @ published application, an application open to public inspections or an issued patent ‘record trom tis system of records may be disclosed, as a routine use, to a Federal, Stat, or local law enforcement agency, the USPTO becomes aware of a violation or potetlal violation of aw or regulation. EFS Web 2220

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