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P O S I T I O N S T A T E M E N T

Nutrition Recommendations and


Interventions for Diabetes
A position statement of the American Diabetes Association
AMERICAN DIABETES ASSOCIATION range or as close to normal as is safely
possible
2) To prevent, or at least slow, the rate of

M
edical nutrition therapy (MNT) is important that all team members, includ-
development of the chronic complica-
important in preventing diabetes, ing physicians and nurses, be knowledge-
tions of diabetes by modifying nutrient
managing existing diabetes, and able about MNT and support its
intake and lifestyle
preventing, or at least slowing, the rate of implementation.
3) To address individual nutrition needs,
development of diabetes complications. It MNT, as illustrated in Table 1, plays a
taking into account personal and cultural
is, therefore, important at all levels of di- role in all three levels of diabetes-related
preferences and willingness to change
abetes prevention (see Table 1). MNT is prevention targeted by the U.S. Depart-
4) To maintain the pleasure of eating by
also an integral component of diabetes ment of Health and Human Services. Pri-
only limiting food choices when indicated
self-management education (or training). mary prevention interventions seek to
by scientific evidence
This position statement provides evi- delay or halt the development of diabetes.
dence-based recommendations and inter- This involves public health measures to Goals of MNT that apply to specific
ventions for diabetes MNT. The previous reduce the prevalence of obesity and in- situations
position statement with accompanying cludes MNT for individuals with pre- 1) For youth with type 1 diabetes, youth
technical review was published in 2002 diabetes. Secondary and tertiary prevention with type 2 diabetes, pregnant and lactat-
(1) and modified slightly in 2004 (2). This interventions include MNT for individuals ing women, and older adults with diabe-
statement updates previous position with diabetes and seek to prevent (sec- tes, to meet the nutritional needs of these
statements, focuses on key references ondary) or control (tertiary) complica- unique times in the life cycle.
published since the year 2000, and uses tions of diabetes. 2) For individuals treated with insulin or
grading according to the level of evidence insulin secretagogues, to provide self-
available based on the American Diabetes GOALS OF MNT FOR management training for safe conduct of
Association evidence-grading system. PREVENTION AND exercise, including the prevention and
Since overweight and obesity are closely TREATMENT OF DIABETES treatment of hypoglycemia, and diabetes
linked to diabetes, particular attention is treatment during acute illness.
paid to this area of MNT. Goals of MNT that apply to
The goal of these recommendations is individuals at risk for diabetes or EFFECTIVENESS OF MNT
to make people with diabetes and health with pre-diabetes Recommendations
care providers aware of beneficial nutri- To decrease the risk of diabetes and car- ● Individuals who have pre-diabetes or
tion interventions. This requires the use diovascular disease (CVD) by promoting diabetes should receive individualized
of the best available scientific evidence healthy food choices and physical activity MNT; such therapy is best provided by
while taking into account treatment goals, leading to moderate weight loss that is a registered dietitian familiar with the
strategies to attain such goals, and maintained. components of diabetes MNT. (B)
changes individuals with diabetes are ● Nutrition counseling should be sensi-
willing and able to make. Achieving nu- Goals of MNT that apply to
tive to the personal needs, willingness
trition-related goals requires a coordi- individuals with diabetes
to change, and ability to make changes
nated team effort that includes the person 1) Achieve and maintain
of the individual with pre-diabetes or
with diabetes and involves him or her in ● Blood glucose levels in the normal diabetes. (E)
the decision-making process. It is recom- range or as close to normal as is safely
mended that a registered dietitian, knowl- possible Clinical trials/outcome studies of
edgeable and skilled in MNT, be the team ● A lipid and lipoprotein profile that re- MNT have reported decreases in HbA1c
member who plays the leading role in duces the risk for vascular disease (A1C) of ⬃1% in type 1 diabetes and
providing nutrition care. However, it is ● Blood pressure levels in the normal 1–2% in type 2 diabetes, depending on
the duration of diabetes (3,4). Meta-
● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
analysis of studies in nondiabetic, free-
Originally approved 2006. Revised 2007.
Writing panel: John P. Bantle (Co-Chair), Judith Wylie-Rosett (Co-Chair), Ann L. Albright, Caroline M.
living subjects and expert committees
Apovian, Nathaniel G. Clark, Marion J. Franz, Byron J. Hoogwerf, Alice H. Lichtenstein, Elizabeth Mayer- report that MNT reduces LDL cholesterol
Davis, Arshag D. Mooradian, and Madelyn L. Wheeler. by 15–25 mg/dl (5,6). After initiation of
Abbreviations: CHD, coronary heart disease; CKD, chronic kidney disease; CVD, cardiovascular disease; MNT, improvements were apparent in
DPP, Diabetes Prevention Program; FDA, Food and Drug Administration; GDM, gestational diabetes mel- 3– 6 months. Meta-analysis and expert
litus; MNT, medical nutrition therapy; RDA, recommended dietary allowance; USDA, U.S. Department of
Agriculture. committees also support a role for lifestyle
DOI: 10.2337/dc08-S061 modification in treating hypertension
© 2008 by the American Diabetes Association. (7,8).

DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008 S61


Nutrition recommendations and interventions

Table 1—Nutrition and MNT


Primary prevention to prevent diabetes: Secondary prevention to prevent complications: Tertiary prevention to prevent morbidity and mortality:
● Use MNT and public health ● Use MNT for metabolic control of diabetes ● Use MNT to delay and manage complications of
interventions in those with obesity diabetes
and pre-diabetes

ENERGY BALANCE, pre-diabetes or diabetes continue to be moderate weight loss (5% of body weight)
OVERWEIGHT, AND studied. (B) in subjects with type 2 diabetes is associ-
OBESITY ated with decreased insulin resistance,
The importance of controlling body improved measures of glycemia and li-
Recommendations weight in reducing risks related to diabe- pemia, and reduced blood pressure (13).
● In overweight and obese insulin- tes is of great importance. Therefore, Longer-term studies (ⱖ52 weeks) using
resistant individuals, modest weight these nutrition recommendations start by pharmacotherapy for weight loss in adults
loss has been shown to improve insulin considering energy balance and weight with type 2 diabetes produced modest re-
resistance. Thus, weight loss is recom- loss strategies. The National Heart, Lung, ductions in weight and A1C (14), al-
mended for all such individuals who and Blood Institute guidelines define though improvement in A1C was not seen
have or are at risk for diabetes. (A) overweight as BMI ⱖ25 kg/m2 and obe- in all studies (15,16). Look AHEAD (Ac-
● For weight loss, either low-carbohy- sity as BMI ⱖ30 kg/m2 (9). The risk of tion for Health in Diabetes) is a large Na-
drate or low-fat calorie-restricted diets comorbidity associated with excess adi- tional Institutes of Health–sponsored
may be effective in the short term (up to pose tissue increases with BMIs in this clinical trial designed to determine if
1 year). (A) range and above. However, clinicians long-term weight loss will improve glyce-
● For patients on low-carbohydrate diets, should be aware that in some Asian pop- mia and prevent cardiovascular events
monitor lipid profiles, renal function, ulations, the proportion of people at high (17). When completed, this study should
and protein intake (in those with ne- risk of type 2 diabetes and CVD is signif- provide insight into the effects of long-
phropathy), and adjust hypoglycemic icant at BMIs of ⬎23 kg/m2 (10). Visceral term weight loss on important clinical
therapy as needed. (E) body fat, as measured by waist circumfer- outcomes.
● Physical activity and behavior modifi- ence ⱖ35 inches in women and ⱖ40 Evidence demonstrates that struc-
cation are important components of inches in men, is used in conjunction tured, intensive lifestyle programs involv-
weight loss programs and are most with BMI to assess risk of type 2 diabetes ing participant education, individualized
helpful in maintenance of weight loss. and CVD (Table 2) (9). Lower waist cir- counseling, reduced dietary energy and
(B) cumference cut points (ⱖ31 inches in fat (⬃30% of total energy) intake, regular
● Weight loss medications may be con- women, ⱖ35 inches in men) may be ap- physical activity, and frequent participant
sidered in the treatment of overweight propriate for Asian populations (11). contact are necessary to produce long-
and obese individuals with type 2 dia- Because of the effects of obesity on term weight loss of 5–7% of starting
betes and can help achieve a 5–10% insulin resistance, weight loss is an im- weight (1). The role of lifestyle modifica-
weight loss when combined with life- portant therapeutic objective for individ- tion in the management of weight and
style modification. (B) uals with pre-diabetes or diabetes (12). type 2 diabetes was recently reviewed
● Bariatric surgery may be considered for However, long-term weight loss is diffi- (13). Although structured lifestyle pro-
some individuals with type 2 diabetes cult for most people to accomplish. This is grams have been effective when delivered
and BMI ⱖ35 kg/m2 and can result in probably because the central nervous sys- in well-funded clinical trials, it is not clear
marked improvements in glycemia. tem plays an important role in regulating how the results should be translated into
The long-term benefits and risks of energy intake and expenditure. Short- clinical practice. Organization, delivery,
bariatric surgery in individuals with term studies have demonstrated that and funding of lifestyle interventions are
all issues that must be addressed. Third-
party payers may not provide adequate
Table 2—Classification of overweight and obesity by BMI, waist circumference, and associ-
benefits for sufficient MNT frequency and
ated disease risk
time to achieve weight loss goals (18).
Exercise and physical activity, by
Disease risk* themselves, have only a modest weight
WC: men ⱖ40 loss effect. However, exercise and physi-
Obesity WC: men ⱕ40 inches; inches; women cal activity are to be encouraged because
BMI (kg/m2) class women ⱕ35 inches ⱖ35 inches they improve insulin sensitivity indepen-
dent of weight loss, acutely lower blood
Underweight ⬍18.5 glucose, and are important in long-term
Normal 18.5–24.9 maintenance of weight loss (1). Weight
Overweight 25.0–29.9 Increased High loss with behavioral therapy alone also
Obesity 30.0–34.9 I High Very high has been modest, and behavioral ap-
35.0–39.9 II Very high Very high proaches may be most useful as an ad-
Extreme obesity ⱖ40 III Extremely high Extremely high junct to other weight loss strategies.
*Disease risk for type 2 diabetes, hypertension, and CVD. Adapted from ref. 9. WC, waist circumference. Standard weight loss diets provide

S62 DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008


Position Statement

500 –1,000 fewer calories than estimated to replace a usual meal can result in sig- fat, can reduce the risk for developing
to be necessary for weight maintenance nificant weight loss. Meal replacements diabetes and are therefore recom-
and initially result in a loss of ⬃1–2 lb/ are an important part of the Look AHEAD mended. (A)
week. Although many people can lose weight loss intervention (17). However, ● Individuals at high risk for type 2 dia-
some weight (as much as 10% of initial meal replacement therapy must be con- betes should be encouraged to achieve
weight in ⬃6 months) with such diets, tinued indefinitely if weight loss is to be the U.S. Department of Agriculture
without continued support and follow- maintained. (USDA) recommendation for dietary fi-
up, people usually regain the weight they Very-low-calorie diets provide ⱕ800 ber (14 g fiber/1,000 kcal) and foods
have lost. calories daily and produce substantial containing whole grains (one-half of
The optimal macronutrient distri- weight loss and rapid improvements in grain intake). (B)
bution of weight loss diets has not been glycemia and lipemia in individuals with ● There is not sufficient, consistent infor-
established. Although low-fat diets have type 2 diabetes. When very-low-calorie mation to conclude that low– glycemic
traditionally been promoted for weight diets are stopped and self-selected meals load diets reduce the risk for diabetes.
loss, two randomized controlled trials are reintroduced, weight regain is com- Nevertheless, low– glycemic index
found that subjects on low-carbohy- mon. Thus, very-low-calorie diets appear foods that are rich in fiber and other
drate diets lost more weight at 6 months to have limited utility in the treatment of important nutrients are to be encour-
than subjects on low-fat diets (19,20). type 2 diabetes and should only be con- aged. (E)
Another study of overweight women sidered in conjunction with a structured ● Observational studies report that mod-
randomized to one of four diets showed weight loss program. erate alcohol intake may reduce the risk
significantly more weight loss at 12 The available data suggest that weight for diabetes, but the data do not sup-
months with the Atkins low-carbohy- loss medications may be useful in the port recommending alcohol consump-
drate diet than with higher-carbohy- treatment of overweight individuals with tion to individuals at risk of diabetes.
drate diets (20a). However, at 1 year, and at risk for type 2 diabetes and can (B)
the difference in weight loss between help achieve a 5–10% weight loss when ● No nutrition recommendation can be
the low-carbohydrate and low-fat diets combined with lifestyle change (14). Ac- made for preventing type 1 diabetes.
was not significant and weight loss was cording to their labels, these medications (E)
modest with both diets. Changes in se- should only be used in people with dia- ● Although there are insufficient data at
rum triglyceride and HDL cholesterol betes who have BMI ⬎27.0 kg/m2. present to warrant any specific recom-
were more favorable with the low- Gastric reduction surgery can be an mendations for prevention of type 2 di-
carbohydrate diets. In one study, those effective weight loss treatment for obesity abetes in youth, it is reasonable to apply
subjects with type 2 diabetes demon- and may be considered in people with di- approaches demonstrated to be effec-
strated a greater decrease in A1C with a abetes who have BMI ⱖ35 kg/m2. A meta- tive in adults, as long as nutritional
low-carbohydrate diet than with a low- analysis of studies of bariatric surgery needs for normal growth and develop-
fat diet (20). A recent meta-analysis reported that 77% of individuals with ment are maintained. (E)
showed that at 6 months, low- type 2 diabetes had complete resolution
carbohydrate diets were associated with of diabetes (normalization of blood glu-
greater improvements in triglyceride cose levels in the absence of medications), The importance of preventing type
and HDL cholesterol concentrations and diabetes was resolved or improved in 2 diabetes is highlighted by the substan-
than low-fat diets; however, LDL cho- 86% (23). In the Swedish Obese Subjects tial worldwide increase in the preva-
lesterol was significantly higher on the study, a 10-year follow-up of individuals lence of diabetes in recent years.
low-carbohydrate diets (21). Further undergoing bariatric surgery, 36% of sub- Genetic susceptibility appears to play a
research is needed to determine the jects with diabetes had resolution of dia- powerful role in the occurrence of type
long-term efficacy and safety of low- betes compared with 13% of matched 2 diabetes. However, given that popu-
carbohydrate diets (13). The recom- control subjects (24). All cardiovascular lation gene pools shift very slowly over
mended dietary allowance (RDA) for risk factors except hypercholesterolemia time, the current epidemic of diabetes
digestible carbohydrate is 130 g/day improved in the surgical patients. likely reflects changes in lifestyle lead-
and is based on providing adequate glu- ing to diabetes. Lifestyle changes char-
cose as the required fuel for the central NUTRITION acterized by increased energy intake
nervous system without reliance on glu- RECOMMENDATIONS AND and decreased physical activity appear
cose production from ingested protein INTERVENTIONS FOR THE to have together promoted overweight
or fat (22). Although brain fuel needs PREVENTION OF DIABETES and obesity, which are strong risk fac-
can be met on lower-carbohydrate di- (PRIMARY PREVENTION) tors for diabetes.
ets, long-term metabolic effects of very- Several studies have demonstrated
low-carbohydrate diets are unclear, and Recommendations the potential for moderate, sustained
such diets eliminate many foods that are ● Among individuals at high risk for de- weight loss to substantially reduce the
important sources of energy, fiber, vita- veloping type 2 diabetes, structured risk for type 2 diabetes, regardless of
mins, and minerals and are important in programs that emphasize lifestyle whether weight loss was achieved by life-
dietary palatability (22). changes that include moderate weight style changes alone or with adjunctive
Meal replacements (liquid or solid loss (7% body weight) and regular therapies such as medication or bariatric-
prepackaged) provide a defined amount physical activity (150 min/week), with surgery (see ENERGY BALANCE section) (1).
of energy, often as a formula product. Use dietary strategies including reduced Moreover, both moderate-intensity and
of meal replacements once or twice daily calories and reduced intake of dietary vigorous exercise can improve insulin

DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008 S63


Nutrition recommendations and interventions

sensitivity, independent of weight loss, studies have demonstrated an association NUTRITION


and reduce risk for type 2 diabetes (1). between glycemic load and risk for diabe- RECOMMENDATIONS FOR
Clinical trial data from both the tes, other studies have been unable to THE MANAGEMENT OF
Finnish Diabetes Prevention study (25) confirm this relationship, and a recent re- DIABETES (SECONDARY
and the Diabetes Prevention Program port showed no association of glycemic PREVENTION)
(DPP) in the U.S (26) strongly support index/glycemic load with insulin sensitiv-
the potential for moderate weight loss to ity (39). Carbohydrate in diabetes
reduce the risk for type 2 diabetes. The Thus, there is not sufficient, consis- management
lifestyle intervention in both trials em- tent information to conclude that low–
phasized lifestyle changes that included glycemic load diets reduce risk for Recommendations
moderate weight loss (7% of body ● A dietary pattern that includes carbo-
diabetes. Prospective randomized clinical
weight) and regular physical activity trials will be necessary to resolve this is- hydrate from fruits, vegetables, whole
(150 min/week), with dietary strategies sue. Nevertheless, low– glycemic index grains, legumes, and low-fat milk is en-
to reduce intake of fat and calories. In foods that are rich in fiber and other im- couraged for good health. (B)
the DPP, subjects in the lifestyle inter- ● Monitoring carbohydrate, whether by
portant nutrients are to be encouraged. A
vention group reported dietary fat in- 2004 American Diabetes Association carbohydrate counting, exchanges, or
takes of ⬃34% of energy at baseline and statement reviewed this issue in depth experienced-based estimation remains
28% of energy after 1 year of interven- (40), and issues related to the role of gly- a key strategy in achieving glycemic
tion (27). A majority of subjects in the control. (A)
cemic index and glycemic load in dia- ● The use of glycemic index and load may
lifestyle intervention group met the
betes management are addressed in more
physical activity goal of 150 min/week provide a modest additional benefit
detail in the CARBOHYDRATE section of this
of moderate physical activity (26,28). In over that observed when total carbohy-
document.
addition to preventing diabetes, the drate is considered alone. (B)
DPP lifestyle intervention improved Observational studies suggest a U- or ● Sucrose-containing foods can be sub-
several CVD risk factors, including J-shaped association between moderate stituted for other carbohydrates in the
dsylipidemia, hypertension, and in- consumption of alcohol (one to three meal plan or, if added to the meal plan,
flammatory markers (29,30). The DPP drinks [15– 45 g alcohol] per day) and covered with insulin or other glucose-
analysis indicated that lifestyle inter- decreased risk of type 2 diabetes (41,42), lowering medications. Care should be
vention was cost-effective (31), but coronary heart disease (CHD) (42,43), taken to avoid excess energy intake. (A)
other analyses suggest that the expected and stroke (44). However, heavy con- ● As for the general population, people
costs needed to be reduced (32). sumption of alcohol (greater than three with diabetes are encouraged to con-
Both the Finnish Diabetes Preven- drinks per day), may be associated with sume a variety of fiber-containing
tion study and the DPP focused on re- increased incidence of diabetes (42). If al- foods. However, evidence is lacking to
duced intake of calories (using reduced cohol is consumed, recommendations recommend a higher fiber intake for
dietary fat as a dietary intervention). Of from the 2005 USDA Dietary Guidelines people with diabetes than for the pop-
note, reduced intake of fat, particularly for Americans suggest no more than one ulation as a whole. (B)
saturated fat, may reduce risk for diabe- drink per day for women and two drinks ● Sugar alcohols and nonnutritive sweet-
tes by producing an energy-indepen- per day for men (45). eners are safe when consumed within
dent improvement in insulin resistance Although selected micronutrients the daily intake levels established by the
(1,33,34), as well as by promoting may affect glucose and insulin metabo- Food and Drug Administration (FDA).
weight loss. It is possible that reduction lism, to date, there are no convincing data (A)
in other macronutrients (e.g., carbohy- that document their role in the develop-
drates) would also be effective in pre- ment of diabetes. Control of blood glucose in an effort
vention of diabetes through promotion to achieve normal or near-normal levels is
of weight loss; however, clinical trial a primary goal of diabetes management.
data on the efficacy of low-carbohydrate Diabetes in youth Food and nutrition interventions that re-
diets for primary prevention of type 2 No nutrition recommendations can be duce postprandial blood glucose excur-
diabetes are not available. made for the prevention of type 1 diabetes sions are important in this regard, since
Several studies have provided evi- at this time (1). Increasing overweight dietary carbohydrate is the major deter-
dence for reduced risk of diabetes with and obesity in youth appears to be related minant of postprandial glucose levels.
increased intake of whole grains and di- to the increased prevalence of type 2 dia- Low-carbohydrate diets might seem to be
etary fiber (1,35–37). Whole grain– betes, particularly in minority adoles- a logical approach to lowering postpran-
containing foods have been associated cents. Although there are insufficient data dial glucose. However, foods that contain
with improved insulin sensitivity, inde- at present to warrant any specific recom- carbohydrate are important sources of en-
pendent of body weight, and dietary fiber mendations for the prevention of type 2 ergy, fiber, vitamins, and minerals and are
has been associated with improved insu- diabetes in youth, interventions similar to important in dietary palatability. There-
lin sensitivity and improved ability to se- those shown to be effective for prevention fore, these foods are important compo-
crete insulin adequately to overcome of type 2 diabetes in adults (lifestyle nents of the diet for individuals with
insulin resistance (38). There is debate as changes including reduced energy intake diabetes. Issues related to carbohydrate
to the potential role of low– glycemic in- and regular physical activity) are likely to and glycemia have previously been exten-
dex and – glycemic load diets in preven- be beneficial. Clinical trials of such inter- sively reviewed in American Diabetes
tion of type 2 diabetes. Although some ventions are ongoing in children. Association reports and nutrition recom-

S64 DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008


Position Statement

mendations for the general public (1,2, glycemic index of a food is the increase vide vitamins, minerals, and other sub-
22,40,45). above fasting in the blood glucose area stances important for good health.
Blood glucose concentration follow- over 2 h after ingestion of a constant Moreover, there are data suggesting that
ing a meal is primarily determined by the amount of that food (usually a 50-g car- consuming a high-fiber diet (⬃50 g fiber/
rate of appearance of glucose in the blood bohydrate portion) divided by the re- day) reduces glycemia in subjects with
stream (digestion and absorption) and its sponse to a reference food (usually type 1 diabetes and glycemia, hyperinsu-
clearance from the circulation (40). Insu- glucose or white bread). The glycemic linemia, and lipemia in subjects with type
lin secretory response normally maintains loads of foods, meals, and diets are calcu- 2 diabetes (1). Palatability, limited food
blood glucose in a narrow range, but in lated by multiplying the glycemic index of choices, and gastrointestinal side effects
individuals with diabetes, defects in insu- the constituent foods by the amounts of are potential barriers to achieving such
lin action, insulin secretion, or both im- carbohydrate in each food and then total- high-fiber intakes. However, increased fi-
pair regulation of postprandial glucose in ing the values for all foods. Foods with ber intake appears to be desirable for peo-
response to dietary carbohydrate. Both low glycemic indexes include oats, barley, ple with diabetes, and a first priority
the quantity and the type or source of car- bulgur, beans, lentils, legumes, pasta, might be to encourage them to achieve the
bohydrates found in foods influence post- pumpernickel (coarse rye) bread, apples, fiber intake goals set for the general pop-
prandial glucose levels. oranges, milk, yogurt, and ice cream. Fi- ulation of 14 g/1,000 kcal (22).
Amount and type of carbohydrate. A ber, fructose, lactose, and fat are dietary Sweeteners. Substantial evidence from
2004 ADA statement addressed the ef- constituents that tend to lower glycemic clinical studies demonstrates that dietary
fects of the amount and type of carbohy- response. Potential methodological prob- sucrose does not increase glycemia more
drate in diabetes management (40). As lems with the glycemic index have been than isocaloric amounts of starch (1).
noted previously, the RDA for carbohy- noted (47). Thus, intake of sucrose and sucrose-
drate (130 g/day) is an average minimum Several randomized clinical trials containing foods by people with diabetes
requirement (22). There are no trials spe- have reported that low– glycemic index does not need to be restricted because of
cifically in patients with diabetes restrict- diets reduce glycemia in diabetic subjects, concern about aggravating hyperglyce-
ing total carbohydrate to ⬍130 g/day. but other clinical trials have not con- mia. Sucrose can be substituted for other
However, 1-year follow-up data from a firmed this effect (40). Moreover, the carbohydrate sources in the meal plan or,
small weight-loss trial (20) indicate, variability in responses to specific carbo- if added to the meal plan, adequately cov-
among the subset with diabetes, that the hydrate-containing food is a concern ered with insulin or another glucose-
reduction in fasting glucose was 21 mg/dl (48). Nevertheless, a recent meta-analysis lowering medication. Additionally, intake
(1.17 mmol/l) and 28 mg/dl (1.55 of low– glycemic index diet trials in dia- of other nutrients ingested with sucrose,
mmol/l) for the low-carbohydrate and betic subjects showed that such diets pro- such as fat, need to be taken into account,
low-fat diets, respectively, with no signif- duced a 0.4% decrement in A1C when and care should be taken to avoid excess
icant difference for change in A1C levels. compared with high– glycemic index di- energy intake.
The 1-year follow-up data also indicate ets (49). However, it appears that most In individuals with diabetes, fructose
that the macronutrient composition of the individuals already consume a moderate– produces a lower postprandial glucose re-
treatment groups only differed with re- glycemic index diet (39,50). Thus, it ap- sponse when it replaces sucrose or starch
spect to carbohydrate intake (mean intake pears that in individuals consuming a in the diet; however, this benefit is tem-
of 230 vs. 120 g). Thus, questions about high– glycemic index diet, low– glycemic pered by concern that fructose may ad-
the long-term effects on intake and me- index diets can produce a modest benefit in versely affect plasma lipids (1). Therefore,
tabolism, as well as safety, need further controlling postprandial hyperglycemia. the use of added fructose as a sweetening
research. In diabetes management, it is impor- agent in the diabetic diet is not recom-
The amount of carbohydrate ingested tant to match doses of insulin and insulin mended. There is, however, no reason to
is usually the primary determinant of secretagogues to the carbohydrate con- recommend that people with diabetes
postprandial response, but the type of car- tent of meals. A variety of methods can be avoid naturally occurring fructose in
bohydrate also affects this response. In- used to estimate the nutrient content of fruits, vegetables, and other foods. Fruc-
trinsic variables that influence the effect of meals, including carbohydrate counting, tose from these sources usually accounts
carbohydrate-containing foods on blood the exchange system, and experience- for only 3– 4% of energy intake.
glucose response include the specific type based estimation. By testing pre- and Reduced calorie sweeteners approved
of food ingested, type of starch (amylose postprandial glucose, many individuals by the FDA include sugar alcohols (poly-
versus amylopectin), style of preparation use experience to evaluate and achieve ols) such as erythritol, isomalt, lactitol,
(cooking method and time, amount of postprandial glucose goals with a variety maltitol, mannitol, sorbitol, xylitol, taga-
heat or moisture used), ripeness, and de- of foods. To date, research has not dem- tose, and hydrogenated starch hydroly-
gree of processing. Extrinsic variables that onstrated that one method of assessing sates. Studies of subjects with and
may influence glucose response include the relationship between carbohydrate in- without diabetes have shown that sugar
fasting or preprandial blood glucose level, take and blood glucose response is better alcohols produce a lower postprandial
macronutrient distribution of the meal in than other methods. glucose response than sucrose or glucose
which the food is consumed, available in- Fiber. As for the general population, and have lower available energy (1). Sugar
sulin, and degree of insulin resistance. people with diabetes are encouraged to alcohols contain, on average, about 2 cal-
The glycemic index of foods was de- choose a variety of fiber-containing foods ories/g (one-half the calories of other
veloped to compare the postprandial re- such as legumes, fiber-rich cereals (ⱖ5 g sweeteners such as sucrose). When calcu-
sponses to constant amounts of different fiber/serving), fruits, vegetables, and lating carbohydrate content of foods con-
carbohydrate-containing foods (46). The whole grain products because they pro- taining sugar alcohols, subtraction of half

DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008 S65


Nutrition recommendations and interventions

the sugar alcohol grams from total carbo- nondiabetic individuals, reducing satu- be adversely affected. Very-long-chain
hydrate grams is appropriate. Use of sugar rated and trans fatty acids and cholesterol n-3 polyunsaturated fatty acid studies in
alcohols as sweeteners reduces the risk of intakes decreases plasma total and LDL individuals with diabetes have primarily
dental caries. However, there is no evi- cholesterol. Reducing saturated fatty ac- used fish oil supplements. Consumption
dence that the amounts of sugar alcohols ids may also reduce HDL cholesterol. Im- of ␻-3 fatty acids from fish or from sup-
likely to be consumed will reduce glyce- portantly, the ratio of LDL cholesterol to plements has been shown to reduce ad-
mia, energy intake, or weight. The use of HDL cholesterol is not adversely affected. verse CVD outcomes, but the evidence for
sugar alcohols appears to be safe; how- Studies in individuals with diabetes dem- ␣-linolenic acid is sparse and inconclu-
ever, they may cause diarrhea, especially onstrating the effects of specific percent- sive (61). In addition to providing n-3
in children. ages of dietary saturated and trans fatty fatty acids, fish frequently displace high–
The FDA has approved five nonnutri- acids and specific amounts of dietary cho- saturated fat– containing foods from the
tive sweeteners for use in the U.S. These lesterol on plasma lipids are not available. diet (62). Two or more servings of fish
are acesulfame potassium, aspartame, Therefore, because of a lack of specific per week (with the exception of com-
neotame, saccharin, and sucralose. Before information, it is recommended that the mercially fried fish filets) (63,64) can be
being allowed on the market, all under- dietary goals for individuals with diabetes recommended.
went rigorous scrutiny and were shown to be the same as for individuals with preex- Plant sterol and stanol esters block
be safe when consumed by the public, in- isting CVD, since the two groups appear the intestinal absorption of dietary and
cluding people with diabetes and women to have equivalent cardiovascular risk. biliary cholesterol. In the general public
during pregnancy. Clinical studies in- Thus, saturated fatty acids ⬍7% of total and in individuals with type 2 diabetes
volving subjects without diabetes provide energy, minimal intake of trans fatty ac- (65), intake of ⬃2 g/day plant sterols and
no indication that nonnutritive sweeten- ids, and cholesterol intake ⬍200 mg daily stanols has been shown to lower plasma
ers in foods will cause weight loss or are recommended. total and LDL cholesterol. A wide range of
weight gain (51). In metabolic studies in which energy foods and beverages are now available
Resistant-starch/high-amylose foods. intake and weight are held constant, diets that contain plant sterols. If these prod-
It has been proposed that foods contain- low in saturated fatty acids and high in ucts are used, they should displace, rather
ing resistant starch (starch physically en- either carbohydrate or cis-monounsat- than be added to, the diet to avoid weight
closed within intact cell structures as in urated fatty acids lowered plasma LDL gain. Soft gel capsules containing plant
some legumes, starch granules as in raw cholesterol equivalently (1,52). The high- sterols are also available.
potato, and retrograde amylose from carbohydrate diets (⬃55% of total energy
plants modified by plant breeding to in- from carbohydrate) increased postpran- Protein in diabetes management
crease amylose content) or high-amylose dial plasma glucose, insulin, and triglyc-
foods, such as specially formulated corn- erides when compared with high– Recommendations
starch, may modify postprandial glycemic monounsaturated fat diets. However, ● For individuals with diabetes and nor-
response, prevent hypoglycemia, and re- high–monounsaturated fat diets have not mal renal function, there is insufficient
duce hyperglycemia. However, there are been shown to improve fasting plasma evidence to suggest that usual protein
no published long-term studies in sub- glucose or A1C values. In other studies, intake (15–20% of energy) should be
jects with diabetes to prove benefit from when energy intake was reduced, the ad- modified. (E)
the use of resistant starch. verse effects of high-carbohydrate diets ● In individuals with type 2 diabetes, in-
were not observed (53,54). Individual gested protein can increase insulin re-
Dietary fat and cholesterol in variability in response to high- sponse without increasing plasma
diabetes management carbohydrate diets suggests that the glucose concentrations. Therefore, pro-
plasma triglyceride response to dietary tein should not be used to treat acute or
Recommendations modification should be monitored care- prevent nighttime hypoglycemia. (A)
● Limit saturated fat to ⬍7% of total cal- fully, particularly in the absence of weight ● High-protein diets are not recom-
ories. (A) loss. mended as a method for weight loss at
● Intake of trans fat should be minimized. Diets high in polyunsaturated fatty this time. The long-term effects of pro-
(E) acids appear to have effects similar to tein intake ⬎20% of calories on diabe-
● In individuals with diabetes, limit di- monounsaturated fatty acids on plasma tes management and its complications
etary cholesterol to ⬍200 mg/day. (E) lipid concentrations (55–58). A modified are unknown. Although such diets may
● Two or more servings of fish per week Mediterranean diet, in which polyunsat- produce short-term weight loss and
(with the exception of commercially urated fatty acids were substituted for improved glycemia, it has not been es-
fried fish filets) provide n-3 polyunsat- monounsaturated fatty acids, reduced tablished that these benefits are main-
urated fatty acids and are recom- overall mortality in elderly Europeans by tained long term, and long-term effects
mended. (B) 7% (59). Very-long-chain n-3 polyunsat- on kidney function for persons with di-
urated fatty acid supplements have been abetes are unknown. (E)
The primary goal with respect to di- shown to lower plasma triglyceride levels
etary fat in individuals with diabetes is to in individuals with type 2 diabetes who The Dietary Reference Intakes’ ac-
limit saturated fatty acids, trans fatty ac- are hypertriglyceridemic. Although the ceptable macronutrient distribution
ids, and cholesterol intakes so as to re- accompanying small rise in plasma LDL range for protein is 10 –35% of energy in-
duce risk for CVD. Saturated and trans cholesterol is of concern, an increase in take, with 15% being the average adult
fatty acids are the principal dietary deter- HDL cholesterol may offset this concern intake in the U.S. and Canada (22). The
minants of plasma LDL cholesterol. In (60). Glucose metabolism is not likely to RDA is 0.8 g good-quality protein 䡠 kg

S66 DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008


Position Statement

body wt⫺1 䡠 day⫺1 (on average, ⬃10% of Alcohol in diabetes management Micronutrients in diabetes
calories) (22). Good-quality protein management
sources are defined as having high PD-
CAAS (protein digestibility– corrected Recommendations
● If adults with diabetes choose to use
amino acid scoring pattern) scores and Recommendations
provide all nine indispensable amino ac- alcohol, daily intake should be limited ● There is no clear evidence of benefit
ids. Examples are meat, poultry, fish, to a moderate amount (one drink per from vitamin or mineral supplementa-
day or less for women and two drinks tion in people with diabetes (compared
eggs, milk, cheese, and soy. Sources not in
per day or less for men). (E) with the general population) who do
the “good” category include cereals, ● To reduce risk of nocturnal hypoglyce-
grains, nuts, and vegetables. In meal plan- not have underlying deficiencies. (A)
mia in individuals using insulin or in- ● Routine supplementation with antioxi-
ning, protein intake should be greater
sulin secretagogues, alcohol should be
than 0.8 g 䡠 kg⫺1 䡠 day⫺1 to account for dants, such as vitamins E and C and
consumed with food. (E) carotene, is not advised because of lack
mixed protein quality in foods. ● In individuals with diabetes, moderate
The dietary intake of protein for indi- of evidence of efficacy and concern re-
alcohol consumption (when ingested lated to long-term safety. (A)
viduals with diabetes is similar to that of alone) has no acute effect on glucose
the general public and usually does not ● Benefit from chromium supplementa-
and insulin concentrations but carbo-
exceed 20% of energy intake. A number tion in individuals with diabetes or obe-
hydrate coingested with alcohol (as in a
of studies in healthy individuals and in sity has not been clearly demonstrated
mixed drink) may raise blood glucose.
individuals with type 2 diabetes have and therefore can not be recom-
(B)
demonstrated that glucose produced mended. (E)
from ingested protein does not increase
plasma glucose concentration but does Abstention from alcohol should be
advised for people with a history of alco- Uncontrolled diabetes is often associ-
produce increases in serum insulin re- ated with micronutrient deficiencies (71).
sponses (1,66). Abnormalities in protein hol abuse or dependence, women during
pregnancy, and people with medical Individuals with diabetes should be aware
metabolism may be caused by insulin de- of the importance of acquiring daily vita-
ficiency and insulin resistance; however, problems such as liver disease, pancreati-
tis, advanced neuropathy, or severe hy- min and mineral requirements from nat-
these are usually corrected with good ural food sources and a balanced diet.
pertriglyceridemia. If individuals choose
blood glucose control (67). Health care providers should focus on nu-
to use alcohol, intake should be limited to
Small, short-term studies in diabetes trition counseling rather than micronutri-
a moderate amount (less than one drink
suggest that diets with protein content ent supplementation in order to reach
per day for adult women and less than
⬎20% of total energy reduce glucose and metabolic control of their patients. Re-
two drinks per day for adult men). One
insulin concentrations, reduce appetite, search including long-term trials is
alcohol containing beverage is defined as
and increase satiety (68,69). However, 12 oz beer, 5 oz wine, or 1.5 oz distilled needed to assess the safety and potentially
the effects of high-protein diets on long- spirits. Each contains ⬃15 g alcohol. beneficial role of chromium, magnesium,
term regulation of energy intake, satiety, Moderate amounts of alcohol, when and antioxidant supplements and other
weight, and the ability of individuals to ingested with food, have minimal acute complementary therapies in the manage-
follow such diets long term have not been effects on plasma glucose and serum in- ment of type 2 diabetes (71a,71b). In se-
adequately studied. sulin concentrations (42). However, car- lect groups such as the elderly, pregnant
Dietary protein and its relationships bohydrate coingested with alcohol may or lactating women, strict vegetarians, or
to hypoglycemia and nephropathy are ad- raise blood glucose. For individuals using those on calorie-restricted diets, a multi-
dressed in later sections. insulin or insulin secretagogues, alcohol vitamin supplement may be needed (1).
should be consumed with food to avoid Antioxidants in diabetes management.
Optimal mix of macronutrients hypoglycemia. Evening consumption of Since diabetes may be a state of increased
Although numerous studies have at- alcohol may increase the risk of nocturnal oxidative stress, there has been interest in
tempted to identify the optimal mix of and fasting hypoglycemia, particularly in antioxidant therapy. Unfortunately, there
macronutrients for the diabetic diet, it is individuals with type 1 diabetes (70). Oc- are no studies examining the effects of di-
unlikely that one such combination of casional use of alcoholic beverages should etary intervention on circulating levels of
macronutrients exists. The best mix of be considered an addition to the regular antioxidants and inflammatory biomark-
carbohydrate, protein, and fat appears to meal plan, and no food should be omit- ers in diabetic volunteers. The few small
vary depending on individual circum- ted. Excessive amounts of alcohol (three clinical studies involving diabetes and
stances. For those individuals seeking or more drinks per day), on a consistent functional foods thought to have high an-
guidance as to macronutrient distribution basis, contributes to hyperglycemia (42). tioxidant potential (e.g., tea, cocoa, cof-
in healthy adults, the Dietary Reference In individuals with diabetes, light to fee) are inconclusive. Clinical trial data
Intakes (DRIs) may be helpful (22). It moderate alcohol intake (one to two not only indicate the lack of benefit with
must be clearly recognized that regardless drinks per day; 15–30 g alcohol) is asso- respect to glycemic control and progres-
of the macronutrient mix, total caloric in- ciated with a decreased risk of CVD (42). sion of complications but also provide ev-
take must be appropriate to weight man- The reduction in CVD does not appear to idence of the potential harm of vitamin E,
agement goals. Further, individualization be due to an increase in plasma HDL cho- carotene, and other antioxidant supple-
of the macronutrient composition will de- lesterol. The type of alcohol-containing ments (1,72,73). In addition, available
pend on the metabolic status of the pa- beverage consumed does not appear to data do not support the use of antioxidant
tient (e.g., lipid profile). make a difference. supplements for CVD risk reduction (74).

DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008 S67


Nutrition recommendations and interventions

Chromium, other minerals, and herbs into an individual’s dietary and physi- Nutrition interventions for type 2
in diabetes management. Chromium, cal activity pattern. (E) diabetes
potassium, magnesium, and possibly zinc ● Individuals using rapid-acting insulin
deficiency may aggravate carbohydrate by injection or an insulin pump should Recommendations
intolerance. Serum levels can readily de- adjust the meal and snack insulin doses ● Individuals with type 2 diabetes are en-
tect the need for potassium or magnesium based on the carbohydrate content of couraged to implement lifestyle modi-
replacement, but detecting deficiency of the meals and snacks. (A) fications that reduce intakes of energy,
zinc or chromium is more difficult (75). ● For individuals using fixed daily insulin saturated and trans fatty acids, choles-
In the late 1990s, two randomized place- doses, carbohydrate intake on a day-to- terol, and sodium and to increase phys-
bo-controlled studies in China found that day basis should be kept consistent ical activity in an effort to improve
chromium supplementation had benefi- with respect to time and amount. (C) glycemia, dyslipidemia, and blood
cial effects on glycemia (76 –78), but the ● For planned exercise, insulin doses can pressure. (E)
chromium status of the study populations be adjusted. For unplanned exercise, ● Plasma glucose monitoring can be used
was not evaluated either at baseline or fol- extra carbohydrate may be needed. (E) to determine whether adjustments in
lowing supplementation. Data from re- foods and meals will be sufficient to
cent small studies indicate that chromium achieve blood glucose goals or if medi-
supplementation may have a role in the The first nutrition priority for indi- cation(s) needs to be combined with
management of glucose intolerance, ges- viduals requiring insulin therapy is to in- MNT. (E)
tational diabetes mellitus (GDM), and tegrate an insulin regimen into their
corticosteroid-induced diabetes (76 –78). lifestyle. With the many insulin options Healthy lifestyle nutrition recom-
However, other well-designed studies now available, an appropriate insulin regi- mendations for the general public are also
have failed to demonstrate any significant men can usually be developed to conform appropriate for individuals with type 2
benefit of chromium supplementation in to an individual’s preferred meal routine, diabetes. Because many individuals with
individuals with impaired glucose intol- food choices, and physical activity pattern. type 2 diabetes are overweight and insulin
erance or type 2 diabetes (79,80). Simi- For individuals receiving basal-bolus in- resistant, MNT should emphasize lifestyle
larly, a meta-analysis of randomized sulin therapy, the total carbohydrate con- changes that result in reduced energy in-
controlled trials failed to demonstrate any tent of meals and snacks is the major take and increased energy expenditure
benefit of chromium picolinate supple- determinant of bolus insulin doses (84). through physical activity. Because many
mentation in reducing body weight (81). Insulin-to-carbohydrate ratios can be individuals also have dyslipidemia and
The FDA concluded that although a small used to adjust mealtime insulin doses. hypertension, reducing saturated and
study suggested that chromium picoli- Several methods can be used to estimate trans fatty acids, cholesterol, and sodium
nate may reduce insulin resistance, the the nutrient content of meals, including is often desirable. Therefore, the first nu-
existence of such a relationship between carbohydrate counting, the exchange sys- trition priority is to encourage individuals
chromium picolinate and either insulin tem, and experience-based estimation. with type 2 diabetes to implement life-
resistance or type 2 diabetes was uncer- The DAFNE (Dose Adjustment for Nor- style strategies that will improve glyce-
tain (http:/www.cfsan.fda.gov/⬃dms/ mal Eating) study (85) demonstrated that mia, dyslipidemia, and blood pressure.
qhccr.html). patients can learn how to use glucose test- Although there are similarities to those
There is insufficient evidence to dem- ing to better match insulin to carbohy- above for type 1 diabetes, MNT recommen-
onstrate efficacy of individual herbs and drate intake. Improvement in A1C dations for established type 2 diabetes differ
supplements in diabetes management without a significant increase in severe in several aspects from both recommen-
(82). In addition, commercially available hypoglycemia was demonstrated, as were dations for type 1 diabetes and the pre-
products are not standardized and vary in positive effects on quality of life, satisfac- vention of diabetes. MNT progresses from
the content of active ingredients. Herbal tion with treatment, and psychological prevention of overweight and obesity, to
preparations also have the potential to in- well-being, even though increases in the improving insulin resistance and prevent-
teract with other medications (83). There- number of insulin injections and blood ing or delaying the onset of diabetes, and
fore, it is important that health care glucose tests were necessary. to contributing to improved metabolic
providers be aware when patients with di- For planned exercise, reduction in in- control in those with diabetes. With es-
abetes are using these products and look sulin dosage is the preferred method to tablished type 2 diabetes treated with
for unusual side effects and herb-drug or prevent hypoglycemia (86). For un- fixed doses of insulin or insulin secreta-
herb-herb interactions planned exercise, intake of additional car- gogues, consistency in timing and carbo-
bohydrate is usually needed. Moderate- hydrate content of meals is important.
intensity exercise increases glucose However, rapid-acting insulins and rap-
NUTRITION utilization by 2–3 mg 䡠 kg⫺1 䡠 min⫺1 id-acting insulin secretagogues allow for
INTERVENTIONS FOR above usual requirements (87). Thus, a more flexible food intake and lifestyle as
SPECIFIC POPULATIONS 70-kg person would need ⬃10 –15 g ad- in individuals with type 1 diabetes.
ditional carbohydrate per hour of moder- Increased physical activity by individ-
Nutrition interventions for type 1 ate intensity physical activity. More uals with type 2 diabetes can lead to im-
diabetes carbohydrate is needed for intense activity. proved glycemia, decreased insulin
A 2005 American Diabetes Associa- resistance, and a reduction in cardiovas-
Recommendations tion statement addresses diabetes MNT cular risk factors, independent of change
● For individuals with type 1 diabetes, for children and adolescents with type 1 in body weight. At least 150 min/week of
insulin therapy should be integrated diabetes (88). moderate-intensity aerobic physical ac-

S68 DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008


Position Statement

tivity, distributed over at least 3 days and ing, and insulin therapy as required for Nutrition interventions for older
with no more than 2 consecutive days glycemic control reduced serious perina- adults with diabetes
without physical activity is recommended tal complications without increasing the
(89). Resistance training is also effective rate of cesarean delivery as compared Recommendations
in improving glycemia and, in the absence with routine care (90). Maternal health– ● Obese older adults with diabetes may
of proliferative retinopathy, people with related quality of life was also improved. benefit from modest energy restriction
type 2 diabetes can be encouraged to per- Hypocaloric diets in obese women and an increase in physical activity; en-
form resistance exercise three times a with GDM can result in ketonemia and ergy requirement may be less than for a
week (89). ketonuria. However, moderate caloric re- younger individual of a similar weight.
striction (reduction by 30% of estimated (E)
Nutrition interventions for energy needs) in obese women with GDM ● A daily multivitamin supplement may
pregnancy and lactation with may improve glycemic control without be appropriate, especially for those
diabetes ketonemia and reduce maternal weight older adults with reduced energy in-
gain. Insufficient data are available to de- take. (C)
Recommendations termine how such diets affect perinatal
● Adequate energy intake that provides The American Geriatrics Society em-
outcomes. Daily food records, weekly
appropriate weight gain is recom- weight checks, and ketone testing can be phasizes the importance of MNT for older
mended during pregnancy. Weight loss used to determine individual energy re- adults with diabetes. For obese individu-
is not recommended; however, for quirements and whether a woman is un- als, a modest weight loss of 5–10% of
overweight and obese women with dereating to avoid insulin therapy. body weight may be indicated (93,94).
GDM, modest energy and carbohydrate The amount and distribution of car- However, an involuntary gain or loss of
restriction may be appropriate. (E) bohydrate should be based on clinical ⬎10 lb or 10% of body weight in ⬍6
● Ketonemia from ketoacidosis or starva- months should be addressed in the MNT
outcome measures (hunger, plasma glu-
tion ketosis should be avoided. (C) cose levels, weight gain, ketone levels), evaluation (1,95,96). Physical activity is
● MNT for GDM focuses on food choices needed to attenuate loss of lean body mass
but a minimum of 175 g carbohydrate/
for appropriate weight gain, normogly- day should be provided (22). Carbohy- that can occur with energy restriction. Ex-
cemia, and absence of ketones. (E) drate should be distributed throughout ercise training can significantly reduce the
● Because GDM is a risk factor for subse- decline in maximal aerobic capacity that
the day in three small- to moderate-sized
quent type 2 diabetes, after delivery, occurs with age, improve risk factors for
meals and two to four snacks. An evening
lifestyle modifications aimed at reduc- atherosclerosis, slow the age-related de-
snack may be needed to prevent acceler-
ing weight and increasing physical ac- cline in lean body mass, decrease central
ated ketosis overnight. Carbohydrate is
tivity are recommended. (A) adiposity, and improve insulin sensitivi-
generally less well tolerated at breakfast
ty—all potentially beneficial for the older
than at other meals.
Prepregnancy MNT includes an indi- adult with diabetes (89,97). However, ex-
vidualized prenatal meal plan to optimize Regular physical activity can help ercise can also pose potential risks such as
blood glucose control. During pregnancy, lower fasting and postprandial plasma cardiac ischemia, musculoskeletal inju-
the distribution of energy and carbohy- glucose concentrations and may be used ries, and hypoglycemia in patients treated
drate intake should be based on the wom- as an adjunct to improve maternal glyce- with insulin or insulin secretagogues.
an’s food and eating habits and plasma mia. If insulin therapy is added to MNT,
glucose responses. Due to the continuous maintaining carbohydrate consistency at NUTRITION
fetal draw of glucose from the mother, meals and snacks becomes a primary goal. RECOMMENDATIONS FOR
maintaining consistency of times and Although most women with GDM re- CONTROLLING DIABETES
amounts of food eaten are important to vert to normal glucose tolerance postpar- COMPLICATIONS
avoidance of hypoglycemia. Plasma glu- tum, they are at increased risk of GDM in (TERTIARY PREVENTION)
cose monitoring and daily food records subsequent pregnancies and type 2 diabe-
provide valuable information for insulin tes later in life. Lifestyle modifications af- Microvascular complications
and meal plan adjustments. ter pregnancy aimed at reducing weight
MNT for GDM primarily involves a and increasing physical activity are rec- Recommendations
carbohydrate-controlled meal plan that ommended, as they reduce the risk of ● Reduction of protein intake to 0.8 –1.0
promotes optimal nutrition for maternal subsequent diabetes (26,91). Breast- g 䡠 kg body wt⫺1 䡠 day⫺1 in individuals
and fetal health with adequate energy for feeding is recommended for infants of with diabetes and the earlier stages of
appropriate gestational weight gain, women with preexisting diabetes or chronic kidney disease (CKD) and to
achievement and maintenance of normo- GDM; however, successful lactation re- 0.8 g 䡠 kg body wt⫺1 䡠 day⫺1 in the later
glycemia, and absence of ketosis. Specific quires planning and coordination of care stages of CKD may improve measures
nutrition and food recommendations are (92). In most situations, breast-feeding of renal function (urine albumin excre-
determined and subsequently modified mothers require less insulin because of tion rate, glomerular filtration rate) and
based on individual assessment and self- the calories expended with nursing. Lac- is recommended. (B)
monitoring of blood glucose. All women tating women have reported fluctuations ● MNT that favorably affects cardiovas-
with GDM should receive MNT at the in blood glucose related to nursing ses- cular risk factors may also have a
time of diagnosis. A recent large clinical sions, often requiring a snack containing favorable effect on microvascular
trial reported that treatment of GDM with carbohydrate before or during breast- complications such as retinopathy and
nutrition therapy, blood glucose monitor- feeding (92). nephropathy. (C)

DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008 S69


Nutrition recommendations and interventions

Progression of diabetes complications ● For patients with diabetes and symp- amount of weight loss, although there is
may be modified by improving glycemic tomatic heart failure, dietary sodium great variability in response (1,7). Regular
control, lowering blood pressure, and, intake of ⬍2,000 mg/day may reduce aerobic physical activity, such as brisk
potentially, reducing protein intake. Nor- symptoms. (C) walking, has an antihypertensive effect
mal protein intake (15–20% of energy) ● In normotensive and hypertensive indi- (7). Although chronic excessive alcohol
does not appear to be associated with risk viduals, a reduced sodium intake (e.g., intake is associated with an increased risk
of developing diabetic nephropathy (1), 2,300 mg/day) with a diet high in fruits, of hypertension, light to moderate alcohol
but the long-term effect on development vegetables, and low-fat dairy products consumption is associated with reduc-
of nephropathy of dietary protein intake lowers blood pressure. (A) tions in blood pressure (7).
⬎20% of energy has not been deter- ● In most individuals, a modest amount Heart failure and peripheral vascular
mined. In several studies of subjects with of weight loss beneficially affects blood disease are common in individuals with
diabetes and microalbuminuria, urinary pressure. (C) diabetes, but little is known about the role
albumin excretion rate and decline in glo- of MNT in treating these complications.
merular filtration were favorably influ- In the EDIC (Epidemiology of Diabe- Nutrition recommendations from the
enced by reduction of protein intake to tes Interventions and Complications) American College of Physicians/American
0.8 –1.0 g 䡠 kg body wt⫺1 䡠 day⫺1 (see study, the follow-up of the DCCT (Diabe- Heart Association suggest moderate so-
PROTEIN IN DIABETES MANAGEMENT section) tes Control and Complications Trial), in- dium restriction (⬍2,000 mg/day) for pa-
(98 –101). Although reduction of protein tensive treatment of type 1 diabetic tients with structural heart disease or
intake to 0.8 g 䡠 kg body wt⫺1 䡠 day⫺1 subjects during the DCCT study period symptomatic heart failure (110). Alcohol
was prescribed, subjects who were not improved glycemic control and signifi- intake is discouraged in patients at high
able to achieve this level of reduction also cantly reduced the risk of the combined risk for heart failure.
showed improvements in renal function end point of cardiovascular death, myo-
(99,100). cardial infarction, and stroke (107). Ad- NUTRITION
In individuals with diabetes and mac- justment for A1C explained most of the INTERVENTIONS FOR
roalbuminuria, reducing protein from all treatment effect. The risk reductions ob- ACUTE COMPLICATIONS
sources to 0.8 g 䡠 kg body wt⫺1 䡠 day⫺1 tained with improved glycemia exceeded AND SPECIAL
has been associated with slowing the de- those that have been demonstrated for CONSIDERATIONS FOR
cline in renal function (1,102); however, other interventions such as cholesterol PATIENTS WITH
such reductions in protein need to main- and blood pressure reductions. Observa- COMORBIDITIES IN ACUTE
tain good nutritional status in patients tional data from the UKPDS suggest that AND CHONIC CARE
with chronic renal failure (103). Al- CVD risk in type 2 diabetes is also pro- FACILITIES
though several studies have explored the portionate to the level of A1C elevation
potential benefit of plant proteins in place (107a). Hypoglycemia
of animal proteins and specific animal There are no large-scale randomized
proteins in diabetic individuals with mi- trials to guide MNT recommendations for Recommendations
croalbuninuria, the data are inconclusive CVD risk reduction in individuals with ● Ingestion of 15–20 g glucose is the pre-
(1,104). type 2 diabetes. However, because CVD ferred treatment for hypoglycemia, al-
Observational data suggest that dys- risk factors are similar in individuals with though any form of carbohydrate that
lipidemia may increase albumin excretion and without diabetes, benefits observed contains glucose may be used. (A)
and the rate of progression of diabetic ne- in nutrition studies in the general popu- ● The response to treatment of hypogly-
phropathy (105). Elevation of plasma lation are probably applicable to individ- cemia should be apparent in 10 –20
cholesterol in both type 1 and 2 diabetic uals with diabetes. The previous section min; however, plasma glucose should
subjects and plasma triglycerides in type on dietary fat addresses the need to re- be tested again in ⬃60 min, as addi-
2 diabetic subjects were predictors of the duce intake of saturated and trans fatty tional treatment may be necessary. (B)
need for renal replacement therapy (106). acids and cholesterol.
Whereas these observations do not con- Hypertension, which is predictive of In individuals taking insulin or insu-
firm that MNT will affect diabetic ne- progression of micro- as well as macro- lin secretagogues, changes in food intake,
phropathy, MNT designed to reduce the vascular complications of diabetes, can be physical activity, and medication can con-
risk for CVD may have favorable effects on prevented and managed with interven- tribute to the development of hypoglyce-
microvascular complications of diabetes. tions including weight loss, physical ac- mia. Treatment of hypoglycemia (plasma
tivity, moderation of alcohol intake, and glucose ⬍70 mg/dl) requires ingestion of
Treatment and management of CVD diets such as DASH (Dietary Approaches glucose or glucose-containing foods. The
risk to Stop Hypertension). The DASH diet acute glycemic response correlates better
emphasized fruits, vegetables, and low-fat with the glucose content than with the
Recommendations dairy products; included whole grains, carbohydrate content of the food (1).
● Target A1C is as close to normal as pos- poultry, fish, and nuts; and was reduced With insulin-induced hypoglycemia, 10 g
sible without significant hypoglycemia. in fats, red meat, sweets, and sugar- oral glucose raises plasma glucose levels
(B) containing beverages (7,108,109). The by ⬃40 mg/dl over 30 min, while 20 g
● For patients with diabetes at risk for effects of lifestyle interventions on hyper- oral glucose raises plasma glucose levels
CVD, diets high in fruits, vegetables, tension appear to be additive. by ⬃60 mg/dl over 45 min. In each case,
whole grains, and nuts may reduce the Reduction in blood pressure in peo- glucose levels often begin to fall ⬃60 min
risk. (C) ple with diabetes can occur with a modest after glucose ingestion (111).

S70 DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008


Position Statement

Table 3—Major nutrition recommendations and interventions


Effectiveness of MNT
● Individuals who have pre-diabetes or diabetes should receive individualized MNT; such therapy is best provided by a registered dietitian
familiar with the components of diabetes MNT. (B)
● Nutrition counseling should be sensitive to the personal needs, willingness to change, and ability to make changes of the individual with
pre-diabetes or diabetes. (E)

Energy balance, overweight, and obesity


● In overweight and obese insulin-resistant individuals, modest weight loss has been shown to improve insulin resistance. Thus, weight
loss is recommended for all such individuals who have or are at risk for diabetes. (A)
● For weight loss, either low-carbohydrate or low-fat calorie-restricted diets may be effective in the short term (up to 1 year). (A)
● For patients on low-carbohydrate diets, monitor lipid profiles, renal function, and protein intake (in those with nephropathy), and adjust
hypoglycemic therapy as needed. (E)
● Physical activity and behavior modification are important components of weight loss programs and are most helpful in maintenance of
weight loss. (B)
● Weight loss medications may be considered in the treatment of overweight and obese individuals with type 2 diabetes and can help
achieve a 5–10% weight loss when combined with lifestyle modification. (B)
● Bariatric surgery may be considered for some individuals with type 2 diabetes and BMI ⱖ35 kg/m2 and can result in marked
improvements in glycemia. The long-term benefits and risks of bariatric surgery in individuals with pre-diabetes or diabetes continue to be
studied. (B)

Preventing diabetes (primary prevention)


● Among individuals at high risk for developing type 2 diabetes, structured programs that emphasize lifestyle changes that include
moderate weight loss (7% body weight) and regular physical activity (150 min/week), with dietary strategies including reduced calories
and reduced intake of dietary fat, can reduce the risk for developing diabetes and are therefore recommended. (A)
● Individuals at high risk for type 2 diabetes should be encouraged to achieve the USDA recommendation for dietary fiber (14 g
fiber/1,000 kcal) and foods containing whole grains (one-half of grain intake). (B)
● There is not sufficient, consistent information to conclude that low–glycemic load diets reduce the risk for diabetes. Nevertheless, low–
glycemic index foods that are rich in fiber and other important nutrients are to be encouraged. (E)
● Observational studies report that moderate alcohol intake may reduce the risk for diabetes, but the data do not support recommending
alcohol consumption to individuals at risk of diabetes. (B)
● No nutrition recommendation can be made for preventing type 1 diabetes. (E)
● Although there are insufficient data at present to warrant any specific recommendations for prevention of type 2 diabetes in youth, it is
reasonable to apply approaches demonstrated to be effective in adults, as long as nutritional needs for normal growth and development are
maintained. (E)

Controlling diabetes (secondary prevention)


Carbohydrate in diabetes management
● A dietary pattern that includes carbohydrate from fruits, vegetables, whole grains, legumes, and low-fat milk is encouraged for good
health. (B)
● Monitoring carbohydrate, whether by carbohydrate counting, exchanges, or experienced-based estimation, remains a key strategy in
achieving glycemic control. (A)
● The use of glycemic index and load may provide a modest additional benefit over that observed when total carbohydrate is considered
alone. (B)
● Sucrose-containing foods can be substituted for other carbohydrates in the meal plan or, if added to the meal plan, covered with
insulin or other glucose-lowering medications. Care should be taken to avoid excess energy intake. (A)
● As for the general population, people with diabetes are encouraged to consume a variety of fiber-containing foods. However, evidence
is lacking to recommend a higher fiber intake for people with diabetes than for the population as a whole. (B)
● Sugar alcohols and nonnutritive sweeteners are safe when consumed within the daily intake levels established by the FDA. (A)
Fat and cholesterol in diabetes management
● Limit saturated fat to ⬍7% of total calories. (A)
● Intake of trans fat should be minimized. (E)
● In individuals with diabetes, lower dietary cholesterol to ⬍200 mg/day. (E)
● Two or more servings of fish per week (with the exception of commercially fried fish filets) provide n-3 polyunsaturated fatty acids
and are recommended. (B)
Protein in diabetes management
● For individuals with diabetes and normal renal function, there is insufficient evidence to suggest that usual protein intake (15–20% of
energy) should be modified. (E)
● In individuals with type 2 diabetes, ingested protein can increase insulin response without increasing plasma glucose concentrations.
Therefore, protein should not be used to treat acute or prevent nighttime hypoglycemia. (A)
Continued on following page

DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008 S71


Nutrition recommendations and interventions

Table 3—Continued
● High-protein diets are not recommended as a method for weight loss at this time. The long-term effects of protein intake ⬎20% of
calories on diabetes management and its complications are unknown. Although such diets may produce short-term weight loss and
improved glycemia, it has not been established that these benefits are maintained long term, and long-term effects on kidney function
for persons with diabetes are unknown. (E)
Alcohol in diabetes management
● If adults with diabetes choose to use alcohol, daily intake should be limited to a moderate amount (one drink per day or less for
women and two drinks per day or less for men). (E)
● To reduce risk of nocturnal hypoglycemia in individuals using insulin or insulin secretagogues, alcohol should be consumed with
food. (E)
● In individuals with diabetes, moderate alcohol consumption (when ingested alone) has no acute effect on glucose and insulin
concentrations but carbohydrate coingested with alcohol (as in a mixed drink) may raise blood glucose. (B)
Micronutrients in diabetes management
● There is no clear evidence of benefit from vitamin or mineral supplementation in people with diabetes (compared with the general
population) who do not have underlying deficiencies. (A)
● Routine supplementation with antioxidants, such as vitamins E and C and carotene, is not advised because of lack of evidence of
efficacy and concern related to long-term safety. (A)
● Benefit from chromium supplementation in individuals with diabetes or obesity has not been clearly demonstrated and therefore can
not be recommended. (E)
Nutrition interventions for type 1 diabetes
● For individuals with type 1 diabetes, insulin therapy should be integrated into an individual’s dietary and physical activity pattern. (E)
● Individuals using rapid-acting insulin by injection or an insulin pump should adjust the meal and snack insulin doses based on the
carbohydrate content of the meals and snacks. (A)
● For individuals using fixed daily insulin doses, carbohydrate intake on a day-to-day basis should be kept consistent with respect to
time and amount. (C)
● For planned exercise, insulin doses can be adjusted. For unplanned exercise, extra carbohydrate may be needed. (E)
Nutrition interventions for type 2 diabetes
● Individuals with type 2 diabetes are encouraged to implement lifestyle modifications that reduce intakes of energy, saturated and trans
fatty acids, cholesterol, and sodium and to increase physical activity in an effort to improve glycemia, dyslipidemia, and blood pressure.
(E)
● Plasma glucose monitoring can be used to determine whether adjustments in foods and meals will be sufficient to achieve blood
glucose goals or if medication(s) needs to be combined with MNT. (E)
Nutrition interventions for pregnancy and lactation with diabetes
● Adequate energy intake that provides appropriate weight gain is recommended during pregnancy. Weight loss is not recommended;
however, for overweight and obese women with GDM, modest energy and carbohydrate restriction may be appropriate. (E)
● Ketonemia from ketoacidosis or starvation ketosis should be avoided. (C)
● MNT for GDM focuses on food choices for appropriate weight gain, normoglycemia, and absence of ketones. (E)
● Because GDM is a risk factor for subsequent type 2 diabetes, after delivery, lifestyle modifications aimed at reducing weight and
increasing physical activity are recommended. (A)
Nutrition interventions for older adults with diabetes
● Obese older adults with diabetes may benefit from modest energy restriction and an increase in physical activity; energy requirement
may be less than for a younger individual of a similar weight. (E)
● A daily multivitamin supplement may be appropriate, especially for those older adults with reduced energy intake. (C)

Treating and controlling diabetes complications (tertiary prevention)


Microvascular complications
● Reduction of protein intake to 0.8–1.0 g 䡠 kg body wt⫺1 䡠 day⫺1 in individuals with diabetes and the earlier stages of CKD and to 0.8 g
䡠 kg body wt⫺1 䡠 day⫺1 in the later stages of CKD may improve measures of renal function (urine albumin excretion rate, glomerular
filtration rate) and is recommended. (B)
● MNT that favorably affects cardiovascular risk factors may also have a favorable effect on microvascular complications such as
retinopathy and nephropathy. (C)
Treatment and management of CVD risk
● Target A1C is as close to normal as possible without significant hypoglycemia. (B)
● For patients with diabetes at risk for CVD, diets high in fruits, vegetables, whole grains, and nuts may reduce the risk. (C)
● For patients with diabetes and symptomatic heart failure, dietary sodium intake of ⬍2,000 mg/day may reduce symptoms. (C)
● In normotensive and hypertensive individuals, a reduced sodium intake (e.g., 2,300 mg/day) with a diet high in fruits, vegetables, and
low-fat dairy products lowers blood pressure. (A)
● In most individuals, a modest amount of weight loss beneficially affects blood pressure. (C)
Continued on following page

S72 DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008


Position Statement

Table 3—Continued
Hypoglycemia
● Ingestion of 15–20 g glucose is the preferred treatment for hypoglycemia, although any form of carbohydrate that contains glucose
may be used. (A)
● The response to treatment of hypoglycemia should be apparent in 10–20 min; however, plasma glucose should be tested again in ⬃60
min, as additional treatment may be necessary. (B)
Acute illness
● During acute illnesses, insulin and oral glucose-lowering medications should be continued. (A)
● During acute illnesses, testing of plasma glucose and ketones, drinking adequate amounts of fluids, and ingesting carbohydrate are all
important. (B)
Acute health care facilities
● Establishing an interdisciplinary team, implementation of MNT, and timely diabetes-specific discharge planning improves the care of
patients with diabetes during and after hospitalizations. (E)
● Hospitals should consider implementing a diabetes meal-planning system that provides consistency in the carbohydrate content of
specific meals. (E)
Long-term care facilities
● The imposition of dietary restrictions on elderly patients with diabetes in long-term care facilities is not warranted. Residents with
diabetes should be served a regular menu, with consistency in the amount and timing of carbohydrate. (C)
● An interdisciplinary team approach is necessary to integrate MNT for patients with diabetes into overall management. (E)
● There is no evidence to support prescribing diets such as “no concentrated sweets” or “no sugar added.” (E)
● In the institutionalized elderly, undernutrition is likely and caution should be exercised when prescribing weight loss diets. (B)

Although pure glucose may be the 200 g carbohydrate daily (45–50 g every consider implementing a consistent-
preferred treatment, any form of carbohy- 3– 4 h) should be sufficient to prevent carbohydrate diabetes meal-planning sys-
drate that contains glucose will raise starvation ketosis (1). tem (114,115). This systems uses meal
blood glucose (111). Adding protein to plans without a specific calorie level but
carbohydrate does not affect the glycemic consistency in the carbohydrate content
Patients with diabetes in acute
response and does not prevent subse- of meals. The carbohydrate contents of
health care facilities
quent hypoglycemia. Adding fat, how- breakfast, lunch, dinner, and snacks may
ever, may retard and then prolong the vary, but the day-to-day carbohydrate
Recommendations
acute glycemic response. During hypo- ●
content of specific meals and snacks is
Establishing an interdisciplinary team,
glycemia, gastric-emptying rates are twice kept constant (114,115). It is recom-
implementation of MNT, and timely di-
as fast as during euglycemia and are sim- mended that the term “ADA diet” no
ilar for liquid and solid foods. abetes-specific discharge planning im-
proves the care of patients with diabetes longer be used, since the ADA no longer
during and after hospitalizations. (E) endorses a single nutrition prescription or
Acute illness ● Hospitals should consider implement- percentages of macronutrients.
ing a diabetes meal-planning system Special nutrition issues include liquid
Recommendations that provides consistency in the carbo- diets, surgical diets, catabolic illnesses,
● During acute illnesses, insulin and oral hydrate content of specific meals. (E) and enteral or parenteral nutrition
glucose-lowering medications should (114,115). Patients requiring clear or full
be continued. (A) Hyperglycemia in hospitalized pa- liquid diets should receive ⬃200 g carbo-
● During acute illnesses, testing of tients is common and represents an im- hydrate/day in equally divided amounts
plasma glucose and ketones, drinking portant marker of poor clinical outcome at meal and snack times. Liquids should
adequate amounts of fluids, and ingest- and mortality in both patients with and not be sugar free. Patients require carbo-
ing carbohydrate are all important. (B) without diabetes (112). Optimizing glu- hydrate and calories, and sugar-free liq-
cose control in these patients is associated uids do not meet these nutritional needs.
Acute illnesses can lead to the devel- with better outcomes (113). An interdis- For tube feedings, either a standard en-
opment of hyperglycemia and, in individ- ciplinary team is needed to integrate MNT teral formula (50% carbohydrate) or a
uals with type 1 diabetes, ketoacidosis. into the overall management plan lower– carbohydrate content formula
During acute illnesses, with the usual ac- (114,115). Diabetes nutrition self- (33– 40% carbohydrate) may be used.
companying increases in counterregula- management education, although poten- Calorie needs for most patients are in the
tory hormones, the need for insulin and tially initiated in the hospital, is usually range of 25–35 kcal/kg every 24 h. Care
oral glucose-lowering medications con- best provided in an outpatient or home must be taken not to overfeed patients
tinues and often is increased. Testing setting where the individual with diabetes because this can exacerbate hyperglyce-
plasma glucose and ketones, drinking ad- is better able to focus on learning needs mia. After surgery, food intake should be
equate amounts of fluid, and ingesting (114,115). initiated as quickly as possible. Progres-
carbohydrate, especially if plasma glucose There is no single meal planning sys- sion from clear liquids to full liquids to
is ⬍100 mg/dl, are all important during tem that is ideal for hospitalized patients. solid foods should be completed as rap-
acute illness. In adults, ingestion of 150 – However, it is suggested that hospitals idly as tolerated.

DIABETES CARE, VOLUME 31, SUPPLEMENT 1, JANUARY 2008 S73


Nutrition recommendations and interventions

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