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Potential cancer theray in conjugation with other chemotherapeutics.This is a valuable paper as the drug dacomitinib has not yet been extensively researched and has not been documented for breast cancer, although there is a fair level of investigation of the drug in terms of other forms of cancer such as lung cancer and other cancer types which may be HER-receptor overexpressing in nature.
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Study on the small molecule receptor tyrosine kinase inhibitor (SMRTKI) Dacomitinib in the context of breast cancer treatment
Potential cancer theray in conjugation with other chemotherapeutics.This is a valuable paper as the drug dacomitinib has not yet been extensively researched and has not been documented for breast cancer, although there is a fair level of investigation of the drug in terms of other forms of cancer such as lung cancer and other cancer types which may be HER-receptor overexpressing in nature.
Potential cancer theray in conjugation with other chemotherapeutics.This is a valuable paper as the drug dacomitinib has not yet been extensively researched and has not been documented for breast cancer, although there is a fair level of investigation of the drug in terms of other forms of cancer such as lung cancer and other cancer types which may be HER-receptor overexpressing in nature.
Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid
tumours- paper summary
Abstract: Purpose Dacomitinib is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors HER1, HER2 and HER4. This first-in-human study investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of dacomitinib in patients with advanced solid malignancies, seven of whom comprised breast cancer as their primary tumour type.