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Phase I dose-escalation study of the pan-HER inhibitor, PF299804, in patients with advanced malignant solid

tumours- paper summary


Abstract:
Purpose
Dacomitinib is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor
receptors HER1, HER2 and HER4.
This first-in-human study investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of
dacomitinib in patients with advanced solid malignancies, seven of whom comprised breast cancer as their primary
tumour type.

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