PATHOPHYSIOLOGIC DIAGRAM - SIADH

Drugs Pulmonary Tumors Intrathoracic Conditions Disease and Injury to CNS

•Antidepressants [Positive-Pressure Breathing] •Brain Tumors
•Chemotherapy agents •Hydrocephalus
•Past Antidiabetic Agents •Head Injury
Produce and Release ADH
Activation of: •Meningitis
Independent of Normal •Baroreceptors
Increased Hypothalamic- •Encephalitis
Enhanced •Cariopulmonary receptors
Posterior Pituitary Gland Hypothalamic Control •Osmoreceptors
action of
ADH on Release
Renal Impaired Hypothalamic-
Tubules Posterior Pituitary Structures

Excess ADH Secretion

Increased Water Reabsorption through Renal Tubule

Edema
Dilutional Hyponatremia Increased Intracellular Water Volume
Increased Plasma Volume

Decreased Aldosterone Secretion Increased Glomerular Filtration Rate

Swollen Cells

Decreased Sodium Reabsorption Increased Sodium Filtration

Natriuresis with Oliguria

Muscle Cramps
Hyponatremia Orthostatic Hypotension
And Weakness

Stupor/coma
Water intoxication